\n",
"\n",
"\n",
" \n",
"
\n",
"
"
],
"text/plain": [
" sid sent \\\n",
"0 0 President Donald J. Trump claims he has the “ ... \n",
"1 0 President Donald J. Trump claims he has the “ ... \n",
"2 2 For clues to what may surface when investigato... \n",
"3 2 For clues to what may surface when investigato... \n",
"4 3 Recent media reports confirm that Deutsche Ban... \n",
"\n",
" ent_text ent_label ent_start end_end \n",
"0 Donald J. Trump PERSON 10 25 \n",
"1 the Justice Department ORG 90 112 \n",
"2 Deutsche Bank ORG 112 125 \n",
"3 Russia GPE 169 175 \n",
"4 Deutsche Bank ORG 34 47 "
]
},
"execution_count": 3,
"metadata": {},
"output_type": "execute_result"
}
],
"source": [
"entities_df = pd.read_csv(os.path.join(DATA_DIR, \"entities.tsv\"), sep=\"\\t\", \n",
" names=[\"sid\", \"sent\", \"ent_text\", \"ent_label\", \"ent_start\", \"end_end\"])\n",
"entities_df.head()"
]
},
{
"cell_type": "markdown",
"metadata": {},
"source": [
"## Different types of entities detected"
]
},
{
"cell_type": "code",
"execution_count": 4,
"metadata": {},
"outputs": [
{
"data": {
"text/plain": [
"ORG 593\n",
"PERSON 314\n",
"GPE 286\n",
"DATE 175\n",
"NORP 109\n",
"MONEY 84\n",
"CARDINAL 76\n",
"LOC 51\n",
"PRODUCT 31\n",
"FAC 21\n",
"ORDINAL 17\n",
"WORK_OF_ART 7\n",
"EVENT 6\n",
"LAW 4\n",
"PERCENT 3\n",
"TIME 2\n",
"LANGUAGE 1\n",
"Name: ent_label, dtype: int64"
]
},
"execution_count": 4,
"metadata": {},
"output_type": "execute_result"
}
],
"source": [
"entities_df[\"ent_label\"].value_counts()"
]
},
{
"cell_type": "markdown",
"metadata": {},
"source": [
"## Common Functions"
]
},
{
"cell_type": "code",
"execution_count": 5,
"metadata": {},
"outputs": [],
"source": [
"def entity_similarity(e1, e2):\n",
" if e1 == e2:\n",
" return 1\n",
" elif e1.find(e2) > -1 or e2.find(e1) > -1:\n",
" return 1\n",
" else:\n",
" t1, t2 = set(e1.lower().split()), set(e2.lower().split())\n",
" score = len(t1.intersection(t2)) / len(t1.union(t2))\n",
" return score\n",
" \n",
"\n",
"def construct_all_pairs(ent_df, sim_threshold):\n",
" ent_pairs_df = pd.DataFrame(list(combinations(ent_df.ent_text, 2)), \n",
" columns=['ent_text_x', 'ent_text_y'])\n",
" # compute similarity\n",
" ent_pairs_df[\"sim\"] = ent_pairs_df.apply(\n",
" lambda row: entity_similarity(row.ent_text_x, row.ent_text_y), axis=1)\n",
" # remove low similarity pairs\n",
" ent_pairs_df = ent_pairs_df[ent_pairs_df[\"sim\"] > sim_threshold]\n",
" # remove textually identical pairs\n",
" ent_pairs_df = ent_pairs_df[ent_pairs_df[\"ent_text_x\"] != ent_pairs_df[\"ent_text_y\"]]\n",
" # LHS should be lexicographically smaller than RHS (upper triangle entries)\n",
" ent_pairs_df = ent_pairs_df[ent_pairs_df[\"ent_text_x\"] <= ent_pairs_df[\"ent_text_y\"]]\n",
" return ent_pairs_df\n",
"\n",
"\n",
"def accumulate_synonyms(ent_pairs_df):\n",
" ent_pairs_grouped_df = (ent_pairs_df.groupby([\"ent_text_x\"])[\"ent_text_y\"]\n",
" .apply(list)\n",
" .reset_index(name=\"syns_list\"))\n",
" ent_pairs_grouped_df[\"synonyms\"] = ent_pairs_grouped_df[\"syns_list\"].str.join(\"|\")\n",
" ent_pairs_grouped_df = ent_pairs_grouped_df.drop(columns=[\"syns_list\"])\n",
" return ent_pairs_grouped_df\n"
]
},
{
"cell_type": "markdown",
"metadata": {},
"source": [
"## ORG"
]
},
{
"cell_type": "code",
"execution_count": 6,
"metadata": {},
"outputs": [
{
"data": {
"text/plain": [
"(0.4, 1)"
]
},
"execution_count": 6,
"metadata": {},
"output_type": "execute_result"
}
],
"source": [
"s1 = entity_similarity(\"the Justice Department\", \"US Department of Justice\")\n",
"s2 = entity_similarity(\"the Southern District\", \"Office for the Southern District of NY\")\n",
"s1, s2"
]
},
{
"cell_type": "code",
"execution_count": 7,
"metadata": {},
"outputs": [
{
"data": {
"text/html": [
"| \n", " | sid | \n", "sent | \n", "ent_text | \n", "ent_label | \n", "ent_start | \n", "end_end | \n", "
|---|---|---|---|---|---|---|
| 0 | \n", "0 | \n", "President Donald J. Trump claims he has the “ ... | \n", "Donald J. Trump | \n", "PERSON | \n", "10 | \n", "25 | \n", "
| 1 | \n", "0 | \n", "President Donald J. Trump claims he has the “ ... | \n", "the Justice Department | \n", "ORG | \n", "90 | \n", "112 | \n", "
| 2 | \n", "2 | \n", "For clues to what may surface when investigato... | \n", "Deutsche Bank | \n", "ORG | \n", "112 | \n", "125 | \n", "
| 3 | \n", "2 | \n", "For clues to what may surface when investigato... | \n", "Russia | \n", "GPE | \n", "169 | \n", "175 | \n", "
| 4 | \n", "3 | \n", "Recent media reports confirm that Deutsche Ban... | \n", "Deutsche Bank | \n", "ORG | \n", "34 | \n", "47 | \n", "
\n",
"\n",
"\n",
" \n",
"
\n",
"
"
],
"text/plain": [
" sid sent \\\n",
"1 0 President Donald J. Trump claims he has the “ ... \n",
"2 2 For clues to what may surface when investigato... \n",
"4 3 Recent media reports confirm that Deutsche Ban... \n",
"9 5 Indeed , Deutsche Bank is a common thread in n... \n",
"12 7 In all the flurry of media attention to the Ru... \n",
"\n",
" ent_text ent_label ent_start end_end \n",
"1 the Justice Department ORG 90 112 \n",
"2 Deutsche Bank ORG 112 125 \n",
"4 Deutsche Bank ORG 34 47 \n",
"9 Deutsche Bank ORG 9 22 \n",
"12 the Department of Justice ORG 103 128 "
]
},
"execution_count": 7,
"metadata": {},
"output_type": "execute_result"
}
],
"source": [
"org_df = entities_df[entities_df[\"ent_label\"] == \"ORG\"]\n",
"org_df.head()"
]
},
{
"cell_type": "code",
"execution_count": 8,
"metadata": {},
"outputs": [
{
"data": {
"text/html": [
"| \n", " | sid | \n", "sent | \n", "ent_text | \n", "ent_label | \n", "ent_start | \n", "end_end | \n", "
|---|---|---|---|---|---|---|
| 1 | \n", "0 | \n", "President Donald J. Trump claims he has the “ ... | \n", "the Justice Department | \n", "ORG | \n", "90 | \n", "112 | \n", "
| 2 | \n", "2 | \n", "For clues to what may surface when investigato... | \n", "Deutsche Bank | \n", "ORG | \n", "112 | \n", "125 | \n", "
| 4 | \n", "3 | \n", "Recent media reports confirm that Deutsche Ban... | \n", "Deutsche Bank | \n", "ORG | \n", "34 | \n", "47 | \n", "
| 9 | \n", "5 | \n", "Indeed , Deutsche Bank is a common thread in n... | \n", "Deutsche Bank | \n", "ORG | \n", "9 | \n", "22 | \n", "
| 12 | \n", "7 | \n", "In all the flurry of media attention to the Ru... | \n", "the Department of Justice | \n", "ORG | \n", "103 | \n", "128 | \n", "
\n",
"\n",
"\n",
" \n",
"
\n",
"
"
],
"text/plain": [
" ent_text_x ent_text_y sim\n",
"7 the Justice Department the US Department of Justice 0.6\n",
"9 the Justice Department the US Department of Justice 0.6\n",
"13 the Justice Department the US Department of Justice 0.6\n",
"36 the Justice Department the US Department of Justice 0.6\n",
"39 the Justice Department the US Department of Justice 0.6\n",
"55 the Justice Department the US Department of Justice 0.6\n",
"222 the Justice Department the US Department of Justice 0.6\n",
"228 the Justice Department the US Department of Justice 0.6\n",
"232 the Justice Department the US Department of Justice 0.6\n",
"264 the Justice Department the US Department of Justice 0.6\n",
"420 the Justice Department the US Department of Justice 0.6\n",
"437 the Justice Department the US Department of Justice 0.6\n",
"511 the Justice Department the US Department of Justice 0.6\n",
"557 the Justice Department the US Department of Justice 0.6\n",
"571 the Justice Department the US Department of Justice 0.6\n",
"581 the Justice Department the Treasury Department 0.5\n",
"585 the Justice Department the US Department of Justice 0.6\n",
"610 Deutsche Bank Deutsche Bank A.G. 1.0\n",
"614 Deutsche Bank Deutsche Bank Trust Company Americas 1.0\n",
"671 Deutsche Bank Deutsche Bank Securities 1.0"
]
},
"execution_count": 8,
"metadata": {},
"output_type": "execute_result"
}
],
"source": [
"org_pairs_df = construct_all_pairs(org_df, 0.35)\n",
"org_pairs_df.head(20)"
]
},
{
"cell_type": "code",
"execution_count": 9,
"metadata": {},
"outputs": [
{
"data": {
"text/html": [
"| \n", " | ent_text_x | \n", "ent_text_y | \n", "sim | \n", "
|---|---|---|---|
| 7 | \n", "the Justice Department | \n", "the US Department of Justice | \n", "0.6 | \n", "
| 9 | \n", "the Justice Department | \n", "the US Department of Justice | \n", "0.6 | \n", "
| 13 | \n", "the Justice Department | \n", "the US Department of Justice | \n", "0.6 | \n", "
| 36 | \n", "the Justice Department | \n", "the US Department of Justice | \n", "0.6 | \n", "
| 39 | \n", "the Justice Department | \n", "the US Department of Justice | \n", "0.6 | \n", "
| 55 | \n", "the Justice Department | \n", "the US Department of Justice | \n", "0.6 | \n", "
| 222 | \n", "the Justice Department | \n", "the US Department of Justice | \n", "0.6 | \n", "
| 228 | \n", "the Justice Department | \n", "the US Department of Justice | \n", "0.6 | \n", "
| 232 | \n", "the Justice Department | \n", "the US Department of Justice | \n", "0.6 | \n", "
| 264 | \n", "the Justice Department | \n", "the US Department of Justice | \n", "0.6 | \n", "
| 420 | \n", "the Justice Department | \n", "the US Department of Justice | \n", "0.6 | \n", "
| 437 | \n", "the Justice Department | \n", "the US Department of Justice | \n", "0.6 | \n", "
| 511 | \n", "the Justice Department | \n", "the US Department of Justice | \n", "0.6 | \n", "
| 557 | \n", "the Justice Department | \n", "the US Department of Justice | \n", "0.6 | \n", "
| 571 | \n", "the Justice Department | \n", "the US Department of Justice | \n", "0.6 | \n", "
| 581 | \n", "the Justice Department | \n", "the Treasury Department | \n", "0.5 | \n", "
| 585 | \n", "the Justice Department | \n", "the US Department of Justice | \n", "0.6 | \n", "
| 610 | \n", "Deutsche Bank | \n", "Deutsche Bank A.G. | \n", "1.0 | \n", "
| 614 | \n", "Deutsche Bank | \n", "Deutsche Bank Trust Company Americas | \n", "1.0 | \n", "
| 671 | \n", "Deutsche Bank | \n", "Deutsche Bank Securities | \n", "1.0 | \n", "
\n",
"\n",
"\n",
" \n",
"
\n",
"
"
],
"text/plain": [
" ent_text_x \\\n",
"0 Alfa \n",
"1 Bank \n",
"2 Bank of Cyprus \n",
"3 Bank of New York \n",
"4 Bannon at Trump Tower \n",
"5 Bloomberg \n",
"6 Commercial Bank of SF \n",
"7 Committee \n",
"8 Crime and Corruption Reporting Project \n",
"9 Department of Financial Services \n",
"\n",
" synonyms \n",
"0 Alfa Group \n",
"1 Deutsche Bank|Deutsche Bank|Deutsche Bank \n",
"2 the Cyprus Popular Bank|the Central Bank of Cy... \n",
"3 New York Times|New York State Department of Fi... \n",
"4 Trump|Trump \n",
"5 Bloomberg News|Bloomberg News \n",
"6 Russian Commercial Bank \n",
"7 the Committee on Financial Services \n",
"8 Organized Crime and Corruption Reporting Project \n",
"9 The Department of Financial Services|The Depar... "
]
},
"execution_count": 9,
"metadata": {},
"output_type": "execute_result"
}
],
"source": [
"org_pairs_grouped_df = accumulate_synonyms(org_pairs_df)\n",
"org_pairs_grouped_df.head(10)"
]
},
{
"cell_type": "code",
"execution_count": 10,
"metadata": {},
"outputs": [],
"source": [
"org_pairs_grouped_df.to_csv(os.path.join(DATA_DIR, \"org_syns.csv\"), index=False)"
]
},
{
"cell_type": "markdown",
"metadata": {},
"source": [
"## PERSON"
]
},
{
"cell_type": "code",
"execution_count": 11,
"metadata": {},
"outputs": [
{
"data": {
"text/plain": [
"(1, 1, 0.6666666666666666, 0.5)"
]
},
"execution_count": 11,
"metadata": {},
"output_type": "execute_result"
}
],
"source": [
"s1 = entity_similarity(\"Jared Kushner\", \"Jared Kushner\")\n",
"s2 = entity_similarity(\"Carl Levin\", \"Levin\")\n",
"s3 = entity_similarity(\"Donald J. Trump\", \"Donald Trump\")\n",
"s4 = entity_similarity(\"Donald J. Trump\", \"Donald Trump Jr.\")\n",
"s1, s2, s3, s4"
]
},
{
"cell_type": "code",
"execution_count": 12,
"metadata": {},
"outputs": [
{
"data": {
"text/html": [
"| \n", " | ent_text_x | \n", "synonyms | \n", "
|---|---|---|
| 0 | \n", "Alfa | \n", "Alfa Group | \n", "
| 1 | \n", "Bank | \n", "Deutsche Bank|Deutsche Bank|Deutsche Bank | \n", "
| 2 | \n", "Bank of Cyprus | \n", "the Cyprus Popular Bank|the Central Bank of Cy... | \n", "
| 3 | \n", "Bank of New York | \n", "New York Times|New York State Department of Fi... | \n", "
| 4 | \n", "Bannon at Trump Tower | \n", "Trump|Trump | \n", "
| 5 | \n", "Bloomberg | \n", "Bloomberg News|Bloomberg News | \n", "
| 6 | \n", "Commercial Bank of SF | \n", "Russian Commercial Bank | \n", "
| 7 | \n", "Committee | \n", "the Committee on Financial Services | \n", "
| 8 | \n", "Crime and Corruption Reporting Project | \n", "Organized Crime and Corruption Reporting Project | \n", "
| 9 | \n", "Department of Financial Services | \n", "The Department of Financial Services|The Depar... | \n", "
\n",
"\n",
"\n",
" \n",
"
\n",
"
"
],
"text/plain": [
" ent_text\n",
"0 Donald J. Trump\n",
"17 Donald Trump\n",
"18 Jared Kushner\n",
"46 Robert Mueller\n",
"70 Breuer"
]
},
"execution_count": 12,
"metadata": {},
"output_type": "execute_result"
}
],
"source": [
"person_df = (entities_df[entities_df[\"ent_label\"] == \"PERSON\"][[\"ent_text\"]]\n",
" .drop_duplicates())\n",
"person_df.head()"
]
},
{
"cell_type": "code",
"execution_count": 13,
"metadata": {},
"outputs": [
{
"data": {
"text/html": [
"| \n", " | ent_text | \n", "
|---|---|
| 0 | \n", "Donald J. Trump | \n", "
| 17 | \n", "Donald Trump | \n", "
| 18 | \n", "Jared Kushner | \n", "
| 46 | \n", "Robert Mueller | \n", "
| 70 | \n", "Breuer | \n", "
\n",
"\n",
"\n",
" \n",
"
\n",
"
"
],
"text/plain": [
" ent_text_x ent_text_y sim\n",
"0 Donald J. Trump Donald Trump 0.666667\n",
"25 Donald J. Trump Trump 1.000000\n",
"183 Donald Trump Trump 1.000000\n",
"207 Donald Trump Donald Trump ’s 1.000000\n",
"293 Donald Trump Elect Donald Trump 1.000000\n",
"298 Donald Trump Donald Trump Jr. 1.000000\n",
"337 Jared Kushner Kushner 1.000000\n",
"674 Breuer Rolf - Ernst Breuer 1.000000\n",
"785 Diane Glossman Glossman 1.000000\n",
"2281 Carl Levin Levin 1.000000\n",
"3520 Kushner n’t Kushner 1.000000\n",
"4074 David Kautter Kautter 1.000000\n",
"4541 Josef Ackerman Josef Ackermann 1.000000\n",
"5460 Tim Wiswell Wiswell 1.000000\n",
"5723 Igor Putin Putin 1.000000\n",
"6838 Maxine Waters Waters 1.000000\n",
"7214 Donald Donald Jr. 1.000000\n",
"7236 Donald Elect Donald Trump 1.000000\n",
"7241 Donald Donald Trump Jr. 1.000000\n",
"7954 Magnitsky Sergei Magnitsky 1.000000"
]
},
"execution_count": 13,
"metadata": {},
"output_type": "execute_result"
}
],
"source": [
"person_pairs_df = construct_all_pairs(person_df, 0.6)\n",
"person_pairs_df.head(20)"
]
},
{
"cell_type": "code",
"execution_count": 14,
"metadata": {},
"outputs": [
{
"data": {
"text/html": [
"| \n", " | ent_text_x | \n", "ent_text_y | \n", "sim | \n", "
|---|---|---|---|
| 0 | \n", "Donald J. Trump | \n", "Donald Trump | \n", "0.666667 | \n", "
| 25 | \n", "Donald J. Trump | \n", "Trump | \n", "1.000000 | \n", "
| 183 | \n", "Donald Trump | \n", "Trump | \n", "1.000000 | \n", "
| 207 | \n", "Donald Trump | \n", "Donald Trump ’s | \n", "1.000000 | \n", "
| 293 | \n", "Donald Trump | \n", "Elect Donald Trump | \n", "1.000000 | \n", "
| 298 | \n", "Donald Trump | \n", "Donald Trump Jr. | \n", "1.000000 | \n", "
| 337 | \n", "Jared Kushner | \n", "Kushner | \n", "1.000000 | \n", "
| 674 | \n", "Breuer | \n", "Rolf - Ernst Breuer | \n", "1.000000 | \n", "
| 785 | \n", "Diane Glossman | \n", "Glossman | \n", "1.000000 | \n", "
| 2281 | \n", "Carl Levin | \n", "Levin | \n", "1.000000 | \n", "
| 3520 | \n", "Kushner | \n", "n’t Kushner | \n", "1.000000 | \n", "
| 4074 | \n", "David Kautter | \n", "Kautter | \n", "1.000000 | \n", "
| 4541 | \n", "Josef Ackerman | \n", "Josef Ackermann | \n", "1.000000 | \n", "
| 5460 | \n", "Tim Wiswell | \n", "Wiswell | \n", "1.000000 | \n", "
| 5723 | \n", "Igor Putin | \n", "Putin | \n", "1.000000 | \n", "
| 6838 | \n", "Maxine Waters | \n", "Waters | \n", "1.000000 | \n", "
| 7214 | \n", "Donald | \n", "Donald Jr. | \n", "1.000000 | \n", "
| 7236 | \n", "Donald | \n", "Elect Donald Trump | \n", "1.000000 | \n", "
| 7241 | \n", "Donald | \n", "Donald Trump Jr. | \n", "1.000000 | \n", "
| 7954 | \n", "Magnitsky | \n", "Sergei Magnitsky | \n", "1.000000 | \n", "
\n",
"\n",
"\n",
" \n",
"
\n",
"
"
],
"text/plain": [
" ent_text_x \\\n",
"0 Ackerman \n",
"1 Alex Sapir \n",
"2 Boris Rotenberg \n",
"3 Breuer \n",
"4 Carl Levin \n",
"5 Crown Prince Mohammed bin Zayed al Nahyan \n",
"6 David Kautter \n",
"7 Diane Glossman \n",
"8 Donald \n",
"9 Donald J. Trump \n",
"\n",
" synonyms \n",
"0 Josef Ackermann \n",
"1 Sapir \n",
"2 Rotenberg \n",
"3 Rolf - Ernst Breuer \n",
"4 Levin \n",
"5 Mohammed bin Zayed \n",
"6 Kautter \n",
"7 Glossman \n",
"8 Donald Jr.|Elect Donald Trump|Donald Trump Jr. \n",
"9 Donald Trump|Trump "
]
},
"execution_count": 14,
"metadata": {},
"output_type": "execute_result"
}
],
"source": [
"person_pairs_grouped_df = accumulate_synonyms(person_pairs_df)\n",
"person_pairs_grouped_df.head(10)"
]
},
{
"cell_type": "code",
"execution_count": 15,
"metadata": {},
"outputs": [],
"source": [
"person_pairs_grouped_df.to_csv(os.path.join(DATA_DIR, \"person_syns.csv\"), index=False)"
]
},
{
"cell_type": "markdown",
"metadata": {},
"source": [
"## GPE + LOC + NORP"
]
},
{
"cell_type": "code",
"execution_count": 16,
"metadata": {},
"outputs": [
{
"data": {
"text/plain": [
"(1, 1)"
]
},
"execution_count": 16,
"metadata": {},
"output_type": "execute_result"
}
],
"source": [
"s1 = entity_similarity(\"Russia\", \"the Russian Federation\")\n",
"s2 = entity_similarity(\"Virgin Island\", \"the British Virgin Islands\")\n",
"s1, s2"
]
},
{
"cell_type": "code",
"execution_count": 17,
"metadata": {},
"outputs": [
{
"data": {
"text/html": [
"| \n", " | ent_text_x | \n", "synonyms | \n", "
|---|---|---|
| 0 | \n", "Ackerman | \n", "Josef Ackermann | \n", "
| 1 | \n", "Alex Sapir | \n", "Sapir | \n", "
| 2 | \n", "Boris Rotenberg | \n", "Rotenberg | \n", "
| 3 | \n", "Breuer | \n", "Rolf - Ernst Breuer | \n", "
| 4 | \n", "Carl Levin | \n", "Levin | \n", "
| 5 | \n", "Crown Prince Mohammed bin Zayed al Nahyan | \n", "Mohammed bin Zayed | \n", "
| 6 | \n", "David Kautter | \n", "Kautter | \n", "
| 7 | \n", "Diane Glossman | \n", "Glossman | \n", "
| 8 | \n", "Donald | \n", "Donald Jr.|Elect Donald Trump|Donald Trump Jr. | \n", "
| 9 | \n", "Donald J. Trump | \n", "Donald Trump|Trump | \n", "
\n",
"\n",
"\n",
" \n",
"
\n",
"
"
],
"text/plain": [
" ent_text\n",
"3 Russia\n",
"6 American\n",
"7 Russian\n",
"10 US\n",
"15 Manhattan"
]
},
"execution_count": 17,
"metadata": {},
"output_type": "execute_result"
}
],
"source": [
"gpe_df = (entities_df[(entities_df[\"ent_label\"] == \"GPE\") | \n",
" (entities_df[\"ent_label\"] == \"LOC\") |\n",
" (entities_df[\"ent_label\"] == \"NORP\")][[\"ent_text\"]]\n",
" .drop_duplicates())\n",
"gpe_df.head()"
]
},
{
"cell_type": "code",
"execution_count": 18,
"metadata": {},
"outputs": [
{
"data": {
"text/html": [
"| \n", " | ent_text | \n", "
|---|---|
| 3 | \n", "Russia | \n", "
| 6 | \n", "American | \n", "
| 7 | \n", "Russian | \n", "
| 10 | \n", "US | \n", "
| 15 | \n", "Manhattan | \n", "
\n",
"\n",
"\n",
" \n",
"
\n",
"
"
],
"text/plain": [
" ent_text_x ent_text_y sim\n",
"1 Russia Russian 1.0\n",
"25 Russia the Russian Federation 1.0\n",
"33 Russia Russians 1.0\n",
"248 Russian the Russian Federation 1.0\n",
"256 Russian Russians 1.0\n",
"556 Southern District the Southern District 1.0\n",
"569 Southern District The Southern District 1.0\n",
"693 New York New Yorker 1.0\n",
"756 New York New York Preet Bharara 1.0\n",
"759 New York New York of Deutsche Bank 1.0\n",
"971 Eastern District the Eastern District 1.0\n",
"972 Eastern District this Eastern District 1.0\n",
"1661 Syria Syrian 1.0\n",
"2948 Latvia Latvian 1.0\n",
"3150 Cyprus the Cyprus Mail 1.0\n",
"3504 Deutsche New York of Deutsche Bank 1.0\n",
"5025 Panama Panama City 1.0\n",
"5103 Seychelles Seychelles Island 1.0\n",
"5406 Constantinos Koudellaris Koudellaris 1.0\n",
"5786 Israel Israeli 1.0\n",
"6118 Africa Africa - Israel 1.0\n",
"6123 Africa East Africa 1.0"
]
},
"execution_count": 18,
"metadata": {},
"output_type": "execute_result"
}
],
"source": [
"gpe_pairs_df = construct_all_pairs(gpe_df, 0.5)\n",
"gpe_pairs_df.head(50)"
]
},
{
"cell_type": "code",
"execution_count": 19,
"metadata": {},
"outputs": [
{
"data": {
"text/html": [
"| \n", " | ent_text_x | \n", "ent_text_y | \n", "sim | \n", "
|---|---|---|---|
| 1 | \n", "Russia | \n", "Russian | \n", "1.0 | \n", "
| 25 | \n", "Russia | \n", "the Russian Federation | \n", "1.0 | \n", "
| 33 | \n", "Russia | \n", "Russians | \n", "1.0 | \n", "
| 248 | \n", "Russian | \n", "the Russian Federation | \n", "1.0 | \n", "
| 256 | \n", "Russian | \n", "Russians | \n", "1.0 | \n", "
| 556 | \n", "Southern District | \n", "the Southern District | \n", "1.0 | \n", "
| 569 | \n", "Southern District | \n", "The Southern District | \n", "1.0 | \n", "
| 693 | \n", "New York | \n", "New Yorker | \n", "1.0 | \n", "
| 756 | \n", "New York | \n", "New York Preet Bharara | \n", "1.0 | \n", "
| 759 | \n", "New York | \n", "New York of Deutsche Bank | \n", "1.0 | \n", "
| 971 | \n", "Eastern District | \n", "the Eastern District | \n", "1.0 | \n", "
| 972 | \n", "Eastern District | \n", "this Eastern District | \n", "1.0 | \n", "
| 1661 | \n", "Syria | \n", "Syrian | \n", "1.0 | \n", "
| 2948 | \n", "Latvia | \n", "Latvian | \n", "1.0 | \n", "
| 3150 | \n", "Cyprus | \n", "the Cyprus Mail | \n", "1.0 | \n", "
| 3504 | \n", "Deutsche | \n", "New York of Deutsche Bank | \n", "1.0 | \n", "
| 5025 | \n", "Panama | \n", "Panama City | \n", "1.0 | \n", "
| 5103 | \n", "Seychelles | \n", "Seychelles Island | \n", "1.0 | \n", "
| 5406 | \n", "Constantinos Koudellaris | \n", "Koudellaris | \n", "1.0 | \n", "
| 5786 | \n", "Israel | \n", "Israeli | \n", "1.0 | \n", "
| 6118 | \n", "Africa | \n", "Africa - Israel | \n", "1.0 | \n", "
| 6123 | \n", "Africa | \n", "East Africa | \n", "1.0 | \n", "
\n",
"\n",
"\n",
" \n",
"
\n",
"
"
],
"text/plain": [
" ent_text_x synonyms\n",
"0 Africa Africa - Israel|East Africa\n",
"1 Constantinos Koudellaris Koudellaris\n",
"2 Cyprus the Cyprus Mail\n",
"3 Deutsche New York of Deutsche Bank\n",
"4 Eastern District the Eastern District|this Eastern District\n",
"5 Israel Israeli\n",
"6 Latvia Latvian\n",
"7 New York New Yorker|New York Preet Bharara|New York of ...\n",
"8 Panama Panama City\n",
"9 Russia Russian|the Russian Federation|Russians"
]
},
"execution_count": 19,
"metadata": {},
"output_type": "execute_result"
}
],
"source": [
"gpe_pairs_grouped_df = accumulate_synonyms(gpe_pairs_df)\n",
"gpe_pairs_grouped_df.head(10)"
]
},
{
"cell_type": "code",
"execution_count": 20,
"metadata": {},
"outputs": [],
"source": [
"gpe_pairs_grouped_df.to_csv(os.path.join(DATA_DIR, \"gpe_syns.csv\"), index=False)"
]
},
{
"cell_type": "markdown",
"metadata": {},
"source": [
"## DATE\n",
"\n",
"Not sure if disambiguation will help, but being able to group narrative by time might. Will consider later when that comes up."
]
},
{
"cell_type": "code",
"execution_count": 21,
"metadata": {},
"outputs": [
{
"data": {
"text/plain": [
"8 the 1990s\n",
"34 December 22\n",
"45 2016\n",
"52 1870\n",
"60 December 1998\n",
"75 2001\n",
"85 just the past decade\n",
"86 December 2016\n",
"90 between 2005 and 2007\n",
"92 2008\n",
"93 2009\n",
"94 2015\n",
"98 June 2015\n",
"100 November 2015\n",
"115 April 2016\n",
"120 April 20 , 2017\n",
"129 March 30 , 2016\n",
"137 January 2017\n",
"154 1996 through 2002\n",
"157 December 21 , 2010\n",
"Name: ent_text, dtype: object"
]
},
"execution_count": 21,
"metadata": {},
"output_type": "execute_result"
}
],
"source": [
"date_df = entities_df[entities_df[\"ent_label\"] == \"DATE\"][\"ent_text\"]\n",
"date_df.head(20)"
]
},
{
"cell_type": "code",
"execution_count": null,
"metadata": {},
"outputs": [],
"source": []
}
],
"metadata": {
"kernelspec": {
"display_name": "Python 3",
"language": "python",
"name": "python3"
},
"language_info": {
"codemirror_mode": {
"name": "ipython",
"version": 3
},
"file_extension": ".py",
"mimetype": "text/x-python",
"name": "python",
"nbconvert_exporter": "python",
"pygments_lexer": "ipython3",
"version": "3.6.7"
}
},
"nbformat": 4,
"nbformat_minor": 2
}
================================================
FILE: src/entity-graph/04-generate-entity-sets.py
================================================
import argparse
import operator
import os
DATA_DIR = "../../data/entity-graph"
parser = argparse.ArgumentParser()
parser.add_argument("-i", "--input", required=True, help="Input file")
parser.add_argument("-o", "--output", required=True, help="Output file")
args = parser.parse_args()
input_file = args.input
output_file = args.output
fout = open(os.path.join(DATA_DIR, output_file), "w")
fin = open(os.path.join(DATA_DIR, input_file), "r")
for line in fin:
line = line.strip()
display_name, synonyms = line.split(',', 1)
synonym_list = synonyms.split('|')
synonym_list.append(display_name)
unique_synonyms = sorted(list(set(synonym_list)), key=len, reverse=True)
display_name = unique_synonyms[0]
synonyms = '|'.join(unique_synonyms[1:])
fout.write("{:s},{:s}\n".format(display_name, synonyms))
fin.close()
fout.close()
================================================
FILE: src/entity-graph/05-find-corefs.py
================================================
import operator
import os
import spacy
import neuralcoref
import nltk
PRONOUNS = set(["he", "she", "him", "her", "they", "their", "it"])
DATA_DIR = "../../data/entity-graph"
TEXT_FILENAME = os.path.join(DATA_DIR, "db-article.txt")
SENTENCES_FILENAME = os.path.join(DATA_DIR, "sentences.tsv")
COREF_FILENAME = os.path.join(DATA_DIR, "corefs.tsv")
def get_coref_clusters(ptext, nlp, offset=0):
output_clusters = []
doc = nlp(ptext)
for coref_cluster in doc._.coref_clusters:
main_text = coref_cluster.main.text
for mention in coref_cluster.mentions:
if nltk.edit_distance(main_text, mention.text) <= 5:
continue
if mention.start_char < offset:
# mentions from previous paragraph, don't report
continue
output_clusters.append((mention.start_char - offset,
mention.end_char - offset,
mention.text,
main_text))
return output_clusters
def partition_mentions_by_sentence(mentions, ptext, para_id, nlp):
curr_sid = 0
fsent = open(SENTENCES_FILENAME, "r")
for line in fsent:
pid, sid, sent = line.strip().split('\t')
pid, sid = int(pid), int(sid)
if pid == para_id:
curr_sid = sid
break
fsent.close()
partitioned_mentions = []
sent_bounds = [(sid, s.start_char, s.end_char) for sid, s in enumerate(nlp(ptext).sents)]
for mention in mentions:
m_sid = None
m_start, m_end, m_text, m_main = mention
for sent_bound in sent_bounds:
sid, s_start, s_end = sent_bound
if m_start >= s_start and m_end <= s_end:
m_sid = sid
m_start -= s_start
m_end -= s_start
break
if m_sid is not None:
partitioned_mentions.append((curr_sid + m_sid, m_start, m_end, m_text, m_main))
return partitioned_mentions
nlp = spacy.load("en")
neuralcoref.add_to_pipe(nlp)
fcoref = open(COREF_FILENAME, "w")
ftext = open(TEXT_FILENAME, "r")
fcoref.write("sid\tm_start\tm_end\tm_text\tm_main\n")
prev_ptext = None
curr_pid, curr_sid = 0, 0
for ptext in ftext:
if curr_pid % 100 == 0:
print("{:d} paragraphs processed".format(curr_pid))
ptext = ptext.strip()
# skip empty lines
if len(ptext) == 0:
continue
# does the text have pronouns
doc = nlp(ptext)
tokens = set([token.text.lower() for token in doc])
if len(tokens.intersection(PRONOUNS)) == 0:
curr_pid += 1
continue
output_clusters = get_coref_clusters(ptext, nlp)
# if we couldn't find corefs even though we had pronouns lets
# increase the scope to previous paragraph as well
if len(output_clusters) == 0 and prev_ptext is not None:
output_clusters = get_coref_clusters(" ".join([prev_ptext, ptext]),
nlp, offset=len(prev_ptext)+1)
# partition the list among individual sentences
partitioned_mentions = partition_mentions_by_sentence(
output_clusters, ptext, curr_pid, nlp)
for mention_p in partitioned_mentions:
pm_sid, pm_start, pm_end, pm_text, pm_main = mention_p
fcoref.write("{:d}\t{:d}\t{:d}\t{:s}\t{:s}\n".format(
pm_sid, pm_start, pm_end, pm_text, pm_main))
# set previous paragraph (in case needed, see above)
prev_ptext = ptext
curr_pid += 1
print("{:d} paragraphs processed, COMPLETE".format(curr_pid))
ftext.close()
fcoref.close()
================================================
FILE: src/entity-graph/06-find-matches.py
================================================
import ahocorasick
import joblib
import operator
import os
DATA_DIR = "../../data/entity-graph"
ENTITY_FILES = ["org_syns.csv", "person_syns.csv", "gpe_syns.csv"]
DICT_FILE = os.path.join(DATA_DIR, "entities_dict.pkl")
DICT_KEYS_FILE = os.path.join(DATA_DIR, "entities_dict.keys")
SENTENCES_FILE = os.path.join(DATA_DIR, "sentences.tsv")
COREF_FILE = os.path.join(DATA_DIR, "corefs.tsv")
MATCHED_ENTITIES_FILE = os.path.join(DATA_DIR, "matched_entities.tsv")
def build_automaton():
print("Building automaton...")
if os.path.exists(DICT_FILE):
A = joblib.load(DICT_FILE)
else:
fkeys = open(DICT_KEYS_FILE, "w")
A = ahocorasick.Automaton()
for entity_file in ENTITY_FILES:
entity_type = entity_file.split('_')[0][0:3]
entity_id = 1
fent = open(os.path.join(DATA_DIR, entity_file), "r")
for line in fent:
line = line.strip()
# print("line:", line)
if line.startswith("ent_text_x,synonyms"):
continue
display_name, synonyms = line.split(',', 1)
# print("display_name:", display_name)
# print("synonyms:", synonyms)
if len(synonyms) == 0:
syn_list = []
else:
syn_list = synonyms.split('|')
# print("syn_list:", syn_list)
syn_list.append(display_name)
unique_syns = list(set(syn_list))
key = "{:s}{:05d}".format(entity_type[0:3], entity_id)
fkeys.write("{:s}\t{:s}\n".format(key, display_name))
for syn in unique_syns:
print("...", key, syn)
A.add_word(syn, (key, syn))
entity_id += 1
A.make_automaton()
fkeys.close()
joblib.dump(A, DICT_FILE)
return A
def find_matches(A, sent_text):
matched_ents = []
for char_end, (eid, ent_text) in A.iter(sent_text):
char_start = char_end - len(ent_text)
matched_ents.append((eid, ent_text, char_start, char_end))
# remove shorter subsumed matches
longest_matched_ents = []
for matched_ent in sorted(matched_ents, key=lambda x: len(x[1]), reverse=True):
# print("matched_ent:", matched_ent)
longest_match_exists = False
char_start, char_end = matched_ent[2], matched_ent[3]
for _, _, ref_start, ref_end in longest_matched_ents:
# print("ref_start:", ref_start, "ref_end:", ref_end)
if ref_start <= char_start and ref_end >= char_end:
longest_match_exists = True
break
if not longest_match_exists:
# print("adding match to longest")
longest_matched_ents.append(matched_ent)
return longest_matched_ents
def find_corefs(coref_file, sid):
corefs = []
fcoref = open(coref_file, "r")
for line in fcoref:
if line.startswith("sid"):
continue
line = line.strip()
m_sid, m_start, m_end, m_text, m_main = line.split('\t')
m_sid = int(m_sid)
if m_sid == sid:
corefs.append((int(m_start), int(m_end), m_text, m_main))
if m_sid > sid:
break
fcoref.close()
return sorted(corefs, key=operator.itemgetter(0), reverse=True)
def replace_corefs(sent_text, corefs):
sent_out = sent_text
for start, end, m_text, m_main in corefs:
sent_out = sent_out[0:start] + m_main + sent_out[end:]
return sent_out
num_sents, num_ents = 0, 0
A = build_automaton()
print("Finding entities...")
fents = open(MATCHED_ENTITIES_FILE, "w")
fsent = open(SENTENCES_FILE, "r")
for line in fsent:
if num_sents % 100 == 0:
print("... {:d} sentences read, {:d} entities written"
.format(num_sents, num_ents))
line = line.strip()
pid, sid, sent_text = line.split('\t')
# extract and replace coreferences with main text in sentence
sent_corefs = find_corefs(COREF_FILE, int(sid))
sent_text = replace_corefs(sent_text, sent_corefs)
# find matches in the coref enhanced sentences
matched_ents = find_matches(A, sent_text)
for eid, ent_text, char_start, char_end in matched_ents:
fents.write("{:s}\t{:s}\t{:s}\t{:s}\t{:d}\t{:d}\n"
.format(pid, sid, eid, ent_text, char_start, char_end))
num_ents += 1
num_sents += 1
print("... {:d} sentences read, {:d} entities written, COMPLETE"
.format(num_sents, num_ents))
fsent.close()
fents.close()
================================================
FILE: src/entity-graph/07-create-graphs.py
================================================
import itertools
import os
import pandas as pd
DATA_DIR = "../../data/entity-graph"
DICT_KEYS_FILE = os.path.join(DATA_DIR, "entities_dict.keys")
MATCHED_ENTITIES_FILE = os.path.join(DATA_DIR, "matched_entities.tsv")
NODE_FILE = os.path.join(DATA_DIR, "neo4j_nodes.csv")
EDGE_FILE = os.path.join(DATA_DIR, "neo4j_edges.csv")
# generate Nodes CSV
fnodes = open(NODE_FILE, "w")
fnodes.write("eid:ID,ename,:LABEL\n")
fkeys = open(DICT_KEYS_FILE, "r")
for line in fkeys:
eid, ename = line.strip().split('\t')
fnodes.write(','.join([eid, ename, eid[0:3].upper()]) + '\n')
fkeys.close()
fnodes.close()
# generate Edges CSV
ents_df = pd.read_csv(MATCHED_ENTITIES_FILE, sep='\t',
names=["pid", "sid", "eid", "etext", "estart", "estop"])
edges_df = (
ents_df[["sid", "eid"]] # extract (sid, eid)
.groupby("sid")["eid"] # group by sid
.apply(list) # (sid, list[eid, ...])
.reset_index(name="eids")
)
# generate entity ID pairs: (sid, list[(eid1, eid2), ...])
edges_df["eids"] = (
edges_df["eids"]
.apply(lambda xs: list(set(xs)))
.apply(lambda xs: [x for x in itertools.combinations(xs, 2)])
)
# unstack the list of pairs
rows = []
for row in edges_df.itertuples():
# note: 1 based because Index is 0
sid = row[1]
for edge in row[2]:
rows.append([edge[0], edge[1], sid])
edges_df = pd.DataFrame(data=rows, columns=[":START_ID", ":END_ID", "sid"])
edges_df[":TYPE"] = "REL"
# print(edges_df.head())
edges_df.to_csv(EDGE_FILE, index=False)
#############################################################################
# Load these files into neo4j by doing the following:
# 1. cd $NEO4J_HOME/data/databases
# 2. rm -rf *
# 3. cd $NEO4J_HOME
# 4. bin/neo4j-admin import --nodes=/path/to/neo4j_nodes.csv \
# --relationships=/path/to/neo4j_edges.csv
# 5. bin/neo4j start
#############################################################################
================================================
FILE: src/entity-graph/08-explore-graph.ipynb
================================================
{
"cells": [
{
"cell_type": "markdown",
"metadata": {},
"source": [
"# Graph Exploration\n",
"\n",
"Graph created using entity co-occurrences in sentences from text of the following posts:\n",
"\n",
"* [Deutsche Bank: A Global Bank for Oligarchs - American and Russian, Part I](https://whowhatwhy.org/2018/01/08/deutsche-bank-global-bank-oligarchs-american-russian-part-1/)\n",
"* [Deutsche Bank: A Global Bank for Oligarchs - American and Russian, Part II](https://whowhatwhy.org/2018/01/15/deutsche-bank-global-bank-oligarchs-american-russian-part-2/)\n",
"* [Deutsche Bank: A Global Bank for Oligarchs - American and Russian, Part III](https://whowhatwhy.org/2018/02/01/deutsche-bank-global-bank-oligarchs-american-russian-part-3/).\n",
"\n",
"In this notebook, we will try to capture the important ideas in the text from the graph, similar to how people build mind-maps to understand complex material."
]
},
{
"cell_type": "code",
"execution_count": 1,
"metadata": {},
"outputs": [],
"source": [
"import pandas as pd\n",
"import py2neo\n",
"import os"
]
},
{
"cell_type": "code",
"execution_count": 2,
"metadata": {},
"outputs": [],
"source": [
"NEO4J_CONN_URL = \"bolt://localhost:7687\"\n",
"NEO4J_USER = \"neo4j\"\n",
"NEO4J_PASS = \"graph\"\n",
"\n",
"DATA_DIR = \"../../data/entity-graph\"\n",
"\n",
"pd.options.display.max_colwidth = 100"
]
},
{
"cell_type": "code",
"execution_count": 3,
"metadata": {},
"outputs": [],
"source": [
"graph = py2neo.Graph(NEO4J_CONN_URL, auth=(NEO4J_USER, NEO4J_PASS))"
]
},
{
"cell_type": "markdown",
"metadata": {},
"source": [
"| \n", " | ent_text_x | \n", "synonyms | \n", "
|---|---|---|
| 0 | \n", "Africa | \n", "Africa - Israel|East Africa | \n", "
| 1 | \n", "Constantinos Koudellaris | \n", "Koudellaris | \n", "
| 2 | \n", "Cyprus | \n", "the Cyprus Mail | \n", "
| 3 | \n", "Deutsche | \n", "New York of Deutsche Bank | \n", "
| 4 | \n", "Eastern District | \n", "the Eastern District|this Eastern District | \n", "
| 5 | \n", "Israel | \n", "Israeli | \n", "
| 6 | \n", "Latvia | \n", "Latvian | \n", "
| 7 | \n", "New York | \n", "New Yorker|New York Preet Bharara|New York of ... | \n", "
| 8 | \n", "Panama | \n", "Panama City | \n", "
| 9 | \n", "Russia | \n", "Russian|the Russian Federation|Russians | \n", "
![](\"graph-snapshot.png\"/)
"
]
},
{
"cell_type": "markdown",
"metadata": {},
"source": [
"## Find Important Nodes"
]
},
{
"cell_type": "code",
"execution_count": 4,
"metadata": {},
"outputs": [],
"source": [
"def get_nodes_by_pagerank(graph, ent_type):\n",
" query = \"\"\"\n",
"CALL algo.pageRank.stream('%s', 'REL', {iterations:20, dampingFactor:0.85})\n",
"YIELD nodeId, score\n",
"RETURN algo.asNode(nodeId).ename AS page, score\n",
"ORDER BY score DESC\n",
" \"\"\" % (ent_type)\n",
" results = graph.run(query).data()\n",
" return pd.DataFrame(results)"
]
},
{
"cell_type": "markdown",
"metadata": {},
"source": [
"### Important People"
]
},
{
"cell_type": "code",
"execution_count": 5,
"metadata": {},
"outputs": [
{
"data": {
"text/html": [
"\n",
"\n",
"\n",
" \n",
"
\n",
"
"
],
"text/plain": [
" page score\n",
"0 Donald J. Trump 1.674359\n",
"1 Jared Kushner 0.731569\n",
"2 Boris Rotenberg 0.439233\n",
"3 Magnitsky 0.405000\n",
"4 Vladimir Putin 0.313868\n",
"5 Steve Bannon 0.305990\n",
"6 Dmitry Firtash 0.277500\n",
"7 Lev Leviev 0.256715\n",
"8 Donald Trump Jr. 0.242898\n",
"9 Alex Sapir 0.213750"
]
},
"execution_count": 5,
"metadata": {},
"output_type": "execute_result"
}
],
"source": [
"important_persons_df = get_nodes_by_pagerank(graph, \"PER\")\n",
"important_persons_df.head(10)"
]
},
{
"cell_type": "markdown",
"metadata": {},
"source": [
"### Important Organizations"
]
},
{
"cell_type": "code",
"execution_count": 6,
"metadata": {},
"outputs": [
{
"data": {
"text/html": [
"| \n", " | page | \n", "score | \n", "
|---|---|---|
| 0 | \n", "Donald J. Trump | \n", "1.674359 | \n", "
| 1 | \n", "Jared Kushner | \n", "0.731569 | \n", "
| 2 | \n", "Boris Rotenberg | \n", "0.439233 | \n", "
| 3 | \n", "Magnitsky | \n", "0.405000 | \n", "
| 4 | \n", "Vladimir Putin | \n", "0.313868 | \n", "
| 5 | \n", "Steve Bannon | \n", "0.305990 | \n", "
| 6 | \n", "Dmitry Firtash | \n", "0.277500 | \n", "
| 7 | \n", "Lev Leviev | \n", "0.256715 | \n", "
| 8 | \n", "Donald Trump Jr. | \n", "0.242898 | \n", "
| 9 | \n", "Alex Sapir | \n", "0.213750 | \n", "
\n",
"\n",
"\n",
" \n",
"
\n",
"
"
],
"text/plain": [
" page score\n",
"0 Deutsche Bank 2.516419\n",
"1 US Senate 1.779962\n",
"2 IRS Office of Appeals 1.422156\n",
"3 US Department of Justice 1.368949\n",
"4 Russian Commercial Bank 0.818218\n",
"5 VTB Capital 0.786680\n",
"6 New York Times 0.443449\n",
"7 Prevezon Holdings 0.417437\n",
"8 Department of Financial Services 0.417437\n",
"9 Treasury Department 0.413723"
]
},
"execution_count": 6,
"metadata": {},
"output_type": "execute_result"
}
],
"source": [
"important_orgs_df = get_nodes_by_pagerank(graph, \"ORG\")\n",
"important_orgs_df.head(10)"
]
},
{
"cell_type": "markdown",
"metadata": {},
"source": [
"### Important Places"
]
},
{
"cell_type": "code",
"execution_count": 7,
"metadata": {},
"outputs": [
{
"data": {
"text/html": [
"| \n", " | page | \n", "score | \n", "
|---|---|---|
| 0 | \n", "Deutsche Bank | \n", "2.516419 | \n", "
| 1 | \n", "US Senate | \n", "1.779962 | \n", "
| 2 | \n", "IRS Office of Appeals | \n", "1.422156 | \n", "
| 3 | \n", "US Department of Justice | \n", "1.368949 | \n", "
| 4 | \n", "Russian Commercial Bank | \n", "0.818218 | \n", "
| 5 | \n", "VTB Capital | \n", "0.786680 | \n", "
| 6 | \n", "New York Times | \n", "0.443449 | \n", "
| 7 | \n", "Prevezon Holdings | \n", "0.417437 | \n", "
| 8 | \n", "Department of Financial Services | \n", "0.417437 | \n", "
| 9 | \n", "Treasury Department | \n", "0.413723 | \n", "
\n",
"\n",
"\n",
" \n",
"
\n",
"
"
],
"text/plain": [
" page score\n",
"0 Russia 1.531063\n",
"1 New York 0.900733\n",
"2 Africa 0.860292\n",
"3 Israel 0.645919\n",
"4 Southern District 0.608951"
]
},
"execution_count": 7,
"metadata": {},
"output_type": "execute_result"
}
],
"source": [
"important_gpes_df = get_nodes_by_pagerank(graph, \"GPE\")\n",
"important_gpes_df.head()"
]
},
{
"cell_type": "markdown",
"metadata": {},
"source": [
"## Find interesting neighbors"
]
},
{
"cell_type": "code",
"execution_count": 8,
"metadata": {},
"outputs": [],
"source": [
"def get_neighbors_by_type(graph, src_name, src_type, neighbor_type):\n",
" query = \"\"\"\n",
"MATCH (e1:%s {ename:\"%s\"})<-[r:REL]->(e2:%s) \n",
"RETURN e1.ename AS src, e2.ename AS dst\n",
" \"\"\" % (src_type, src_name, neighbor_type)\n",
" results = graph.run(query).data()\n",
" results_df = (pd.DataFrame(results)\n",
" .groupby([\"src\", \"dst\"])[\"dst\"]\n",
" .count()\n",
" .reset_index(name=\"count\")\n",
" .sort_values(\"count\", ascending=False)\n",
" )\n",
" return results_df"
]
},
{
"cell_type": "markdown",
"metadata": {},
"source": [
"### Neighbors of Donald J. Trump"
]
},
{
"cell_type": "code",
"execution_count": 9,
"metadata": {},
"outputs": [
{
"data": {
"text/html": [
"| \n", " | page | \n", "score | \n", "
|---|---|---|
| 0 | \n", "Russia | \n", "1.531063 | \n", "
| 1 | \n", "New York | \n", "0.900733 | \n", "
| 2 | \n", "Africa | \n", "0.860292 | \n", "
| 3 | \n", "Israel | \n", "0.645919 | \n", "
| 4 | \n", "Southern District | \n", "0.608951 | \n", "
\n",
"\n",
"\n",
" \n",
"
\n",
"
"
],
"text/plain": [
" src dst count\n",
"4 Donald J. Trump Jared Kushner 14\n",
"5 Donald J. Trump Lev Leviev 4\n",
"7 Donald J. Trump Preet Bharara 4\n",
"11 Donald J. Trump Steve Bannon 4\n",
"0 Donald J. Trump Alex Sapir 2"
]
},
"execution_count": 9,
"metadata": {},
"output_type": "execute_result"
}
],
"source": [
"djt_per_neighbors_df = get_neighbors_by_type(graph, \"Donald J. Trump\", \"PER\", \"PER\")\n",
"djt_per_neighbors_df.head()"
]
},
{
"cell_type": "code",
"execution_count": 10,
"metadata": {},
"outputs": [
{
"data": {
"text/html": [
"| \n", " | src | \n", "dst | \n", "count | \n", "
|---|---|---|---|
| 4 | \n", "Donald J. Trump | \n", "Jared Kushner | \n", "14 | \n", "
| 5 | \n", "Donald J. Trump | \n", "Lev Leviev | \n", "4 | \n", "
| 7 | \n", "Donald J. Trump | \n", "Preet Bharara | \n", "4 | \n", "
| 11 | \n", "Donald J. Trump | \n", "Steve Bannon | \n", "4 | \n", "
| 0 | \n", "Donald J. Trump | \n", "Alex Sapir | \n", "2 | \n", "
\n",
"\n",
"\n",
" \n",
"
\n",
"
"
],
"text/plain": [
" src dst count\n",
"1 Donald J. Trump Deutsche Bank 24\n",
"6 Donald J. Trump US Department of Justice 5\n",
"2 Donald J. Trump IRS Office of Appeals 3\n",
"4 Donald J. Trump Prevezon Holdings 2\n",
"0 Donald J. Trump Department of Financial Services 1"
]
},
"execution_count": 10,
"metadata": {},
"output_type": "execute_result"
}
],
"source": [
"djt_org_neighbors_df = get_neighbors_by_type(graph, \"Donald J. Trump\", \"PER\", \"ORG\")\n",
"djt_org_neighbors_df.head()"
]
},
{
"cell_type": "code",
"execution_count": 11,
"metadata": {},
"outputs": [
{
"data": {
"text/html": [
"| \n", " | src | \n", "dst | \n", "count | \n", "
|---|---|---|---|
| 1 | \n", "Donald J. Trump | \n", "Deutsche Bank | \n", "24 | \n", "
| 6 | \n", "Donald J. Trump | \n", "US Department of Justice | \n", "5 | \n", "
| 2 | \n", "Donald J. Trump | \n", "IRS Office of Appeals | \n", "3 | \n", "
| 4 | \n", "Donald J. Trump | \n", "Prevezon Holdings | \n", "2 | \n", "
| 0 | \n", "Donald J. Trump | \n", "Department of Financial Services | \n", "1 | \n", "
\n",
"\n",
"\n",
" \n",
"
\n",
"
"
],
"text/plain": [
" src dst count\n",
"3 Donald J. Trump Russia 7\n",
"2 Donald J. Trump New York 5\n",
"5 Donald J. Trump Southern District 5\n",
"4 Donald J. Trump Seychelles 2\n",
"0 Donald J. Trump Africa 1"
]
},
"execution_count": 11,
"metadata": {},
"output_type": "execute_result"
}
],
"source": [
"djt_org_neighbors_df = get_neighbors_by_type(graph, \"Donald J. Trump\", \"PER\", \"GPE\")\n",
"djt_org_neighbors_df.head()"
]
},
{
"cell_type": "markdown",
"metadata": {},
"source": [
"### Neighbors of Jared Kushner"
]
},
{
"cell_type": "code",
"execution_count": 12,
"metadata": {},
"outputs": [
{
"data": {
"text/html": [
"| \n", " | src | \n", "dst | \n", "count | \n", "
|---|---|---|---|
| 3 | \n", "Donald J. Trump | \n", "Russia | \n", "7 | \n", "
| 2 | \n", "Donald J. Trump | \n", "New York | \n", "5 | \n", "
| 5 | \n", "Donald J. Trump | \n", "Southern District | \n", "5 | \n", "
| 4 | \n", "Donald J. Trump | \n", "Seychelles | \n", "2 | \n", "
| 0 | \n", "Donald J. Trump | \n", "Africa | \n", "1 | \n", "
\n",
"\n",
"\n",
" \n",
"
\n",
"
"
],
"text/plain": [
" src dst count\n",
"1 Jared Kushner Donald J. Trump 14\n",
"3 Jared Kushner Lev Leviev 4\n",
"7 Jared Kushner Sergey Gorkov 4\n",
"8 Jared Kushner Steve Bannon 4\n",
"5 Jared Kushner Preet Bharara 3"
]
},
"execution_count": 12,
"metadata": {},
"output_type": "execute_result"
}
],
"source": [
"kush_per_neighbors_df = get_neighbors_by_type(graph, \"Jared Kushner\", \"PER\", \"PER\")\n",
"kush_per_neighbors_df.head()"
]
},
{
"cell_type": "code",
"execution_count": 13,
"metadata": {},
"outputs": [
{
"data": {
"text/html": [
"| \n", " | src | \n", "dst | \n", "count | \n", "
|---|---|---|---|
| 1 | \n", "Jared Kushner | \n", "Donald J. Trump | \n", "14 | \n", "
| 3 | \n", "Jared Kushner | \n", "Lev Leviev | \n", "4 | \n", "
| 7 | \n", "Jared Kushner | \n", "Sergey Gorkov | \n", "4 | \n", "
| 8 | \n", "Jared Kushner | \n", "Steve Bannon | \n", "4 | \n", "
| 5 | \n", "Jared Kushner | \n", "Preet Bharara | \n", "3 | \n", "
\n",
"\n",
"\n",
" \n",
"
\n",
"
"
],
"text/plain": [
" src dst count\n",
"1 Jared Kushner Deutsche Bank 14\n",
"2 Jared Kushner New York Times 2\n",
"3 Jared Kushner Prevezon Holdings 2\n",
"4 Jared Kushner US Department of Justice 2\n",
"0 Jared Kushner Department of Financial Services 1"
]
},
"execution_count": 13,
"metadata": {},
"output_type": "execute_result"
}
],
"source": [
"kush_org_neighbors_df = get_neighbors_by_type(graph, \"Jared Kushner\", \"PER\", \"ORG\")\n",
"kush_org_neighbors_df.head()"
]
},
{
"cell_type": "code",
"execution_count": 14,
"metadata": {},
"outputs": [
{
"data": {
"text/html": [
"| \n", " | src | \n", "dst | \n", "count | \n", "
|---|---|---|---|
| 1 | \n", "Jared Kushner | \n", "Deutsche Bank | \n", "14 | \n", "
| 2 | \n", "Jared Kushner | \n", "New York Times | \n", "2 | \n", "
| 3 | \n", "Jared Kushner | \n", "Prevezon Holdings | \n", "2 | \n", "
| 4 | \n", "Jared Kushner | \n", "US Department of Justice | \n", "2 | \n", "
| 0 | \n", "Jared Kushner | \n", "Department of Financial Services | \n", "1 | \n", "
\n",
"\n",
"\n",
" \n",
"
\n",
"
"
],
"text/plain": [
" src dst count\n",
"3 Jared Kushner New York 6\n",
"4 Jared Kushner Russia 5\n",
"6 Jared Kushner Southern District 4\n",
"0 Jared Kushner Africa 3\n",
"1 Jared Kushner Eastern District 2"
]
},
"execution_count": 14,
"metadata": {},
"output_type": "execute_result"
}
],
"source": [
"kush_gpe_neighbors_df = get_neighbors_by_type(graph, \"Jared Kushner\", \"PER\", \"GPE\")\n",
"kush_gpe_neighbors_df.head()"
]
},
{
"cell_type": "markdown",
"metadata": {},
"source": [
"## Find nature of relationship"
]
},
{
"cell_type": "code",
"execution_count": 15,
"metadata": {},
"outputs": [
{
"data": {
"text/plain": [
"585"
]
},
"execution_count": 15,
"metadata": {},
"output_type": "execute_result"
}
],
"source": [
"def build_sentence_dictionary(sent_file):\n",
" sent_dict = {}\n",
" fsent = open(sent_file, \"r\")\n",
" for line in fsent:\n",
" pid, sid, sent_text = line.strip().split('\\t')\n",
" sent_dict[sid] = sent_text\n",
" fsent.close()\n",
" return sent_dict\n",
"\n",
"sent_dict = build_sentence_dictionary(os.path.join(DATA_DIR, \"sentences.tsv\"))\n",
"len(sent_dict)"
]
},
{
"cell_type": "code",
"execution_count": 16,
"metadata": {},
"outputs": [],
"source": [
"def show_connecting_sentences(graph, src_name, src_type, dst_name, dst_type, sent_dict):\n",
" query = \"\"\"\n",
"MATCH (e1:%s {ename:\"%s\"})<-[r:REL]->(e2:%s {ename:\"%s\"}) \n",
"RETURN e1.ename AS src, e2.ename AS dst, r.sid AS sid\n",
"ORDER BY sid\n",
" \"\"\" % (src_type, src_name, dst_type, dst_name)\n",
" result = graph.run(query).data()\n",
" result_df = pd.DataFrame(result)\n",
" result_df[\"sent_text\"] = result_df[\"sid\"].apply(lambda x: sent_dict[x])\n",
" return result_df"
]
},
{
"cell_type": "markdown",
"metadata": {},
"source": [
"### Donald J. Trump and Deutsche Bank"
]
},
{
"cell_type": "code",
"execution_count": 17,
"metadata": {},
"outputs": [
{
"data": {
"text/html": [
"| \n", " | src | \n", "dst | \n", "count | \n", "
|---|---|---|---|
| 3 | \n", "Jared Kushner | \n", "New York | \n", "6 | \n", "
| 4 | \n", "Jared Kushner | \n", "Russia | \n", "5 | \n", "
| 6 | \n", "Jared Kushner | \n", "Southern District | \n", "4 | \n", "
| 0 | \n", "Jared Kushner | \n", "Africa | \n", "3 | \n", "
| 1 | \n", "Jared Kushner | \n", "Eastern District | \n", "2 | \n", "
\n",
"\n",
"\n",
" \n",
"
\n",
"
"
],
"text/plain": [
" src dst sid \\\n",
"0 Donald J. Trump Deutsche Bank 23 \n",
"1 Donald J. Trump Deutsche Bank 232 \n",
"2 Donald J. Trump Deutsche Bank 233 \n",
"3 Donald J. Trump Deutsche Bank 238 \n",
"4 Donald J. Trump Deutsche Bank 240 \n",
"5 Donald J. Trump Deutsche Bank 244 \n",
"6 Donald J. Trump Deutsche Bank 245 \n",
"7 Donald J. Trump Deutsche Bank 248 \n",
"8 Donald J. Trump Deutsche Bank 249 \n",
"9 Donald J. Trump Deutsche Bank 250 \n",
"\n",
" sent_text \n",
"0 Does the fact that Deutsche Bank is currently on the hook for approximately $ 360 million in loa... \n",
"1 The letter further goes on to note that “ the suspicious ties between President ( Donald ) Trump... \n",
"2 Waters ’s letter also reminds the chairman of Trump and his companies ’ estimated $ 360 million ... \n",
"3 Does Donald Trump have a conflict of interest with Deutsche Bank with regard to any potential cr... \n",
"4 Donald Trump ’s relationship with Deutsche Bank began in 1998 when he negotiated , and received ... \n",
"5 Through the years , he sought more loans from Deutsche . \n",
"6 It should be noted that Trump sued Deutsche Bank in 2008 when it called in a big loan that Trump... \n",
"7 Not long after the nastiness of the 2008 countersuits , Trump ’s business with Deutsche moved fr... \n",
"8 Trump ’s wealth manager at Deutsche , Rosemary Vrablic , specializes in real estate and is close... \n",
"9 In the past six years , the Deutsche Bank private wealth unit helped finance three of Trump ’s p... "
]
},
"execution_count": 17,
"metadata": {},
"output_type": "execute_result"
}
],
"source": [
"djt_db_rel_df = show_connecting_sentences(graph, \"Donald J. Trump\", \"PER\", \"Deutsche Bank\", \"ORG\", sent_dict)\n",
"djt_db_rel_df.head(10)"
]
},
{
"cell_type": "markdown",
"metadata": {},
"source": [
"### Donald J. Trump and Jared Kushner"
]
},
{
"cell_type": "code",
"execution_count": 18,
"metadata": {},
"outputs": [
{
"data": {
"text/html": [
"| \n", " | src | \n", "dst | \n", "sid | \n", "sent_text | \n", "
|---|---|---|---|---|
| 0 | \n", "Donald J. Trump | \n", "Deutsche Bank | \n", "23 | \n", "Does the fact that Deutsche Bank is currently on the hook for approximately $ 360 million in loa... | \n", "
| 1 | \n", "Donald J. Trump | \n", "Deutsche Bank | \n", "232 | \n", "The letter further goes on to note that “ the suspicious ties between President ( Donald ) Trump... | \n", "
| 2 | \n", "Donald J. Trump | \n", "Deutsche Bank | \n", "233 | \n", "Waters ’s letter also reminds the chairman of Trump and his companies ’ estimated $ 360 million ... | \n", "
| 3 | \n", "Donald J. Trump | \n", "Deutsche Bank | \n", "238 | \n", "Does Donald Trump have a conflict of interest with Deutsche Bank with regard to any potential cr... | \n", "
| 4 | \n", "Donald J. Trump | \n", "Deutsche Bank | \n", "240 | \n", "Donald Trump ’s relationship with Deutsche Bank began in 1998 when he negotiated , and received ... | \n", "
| 5 | \n", "Donald J. Trump | \n", "Deutsche Bank | \n", "244 | \n", "Through the years , he sought more loans from Deutsche . | \n", "
| 6 | \n", "Donald J. Trump | \n", "Deutsche Bank | \n", "245 | \n", "It should be noted that Trump sued Deutsche Bank in 2008 when it called in a big loan that Trump... | \n", "
| 7 | \n", "Donald J. Trump | \n", "Deutsche Bank | \n", "248 | \n", "Not long after the nastiness of the 2008 countersuits , Trump ’s business with Deutsche moved fr... | \n", "
| 8 | \n", "Donald J. Trump | \n", "Deutsche Bank | \n", "249 | \n", "Trump ’s wealth manager at Deutsche , Rosemary Vrablic , specializes in real estate and is close... | \n", "
| 9 | \n", "Donald J. Trump | \n", "Deutsche Bank | \n", "250 | \n", "In the past six years , the Deutsche Bank private wealth unit helped finance three of Trump ’s p... | \n", "
\n",
"\n",
"\n",
" \n",
"
\n",
"
"
],
"text/plain": [
" src dst sid \\\n",
"0 Donald J. Trump Jared Kushner 109 \n",
"1 Donald J. Trump Jared Kushner 249 \n",
"2 Donald J. Trump Jared Kushner 402 \n",
"3 Donald J. Trump Jared Kushner 411 \n",
"4 Donald J. Trump Jared Kushner 417 \n",
"5 Donald J. Trump Jared Kushner 444 \n",
"6 Donald J. Trump Jared Kushner 445 \n",
"7 Donald J. Trump Jared Kushner 464 \n",
"8 Donald J. Trump Jared Kushner 468 \n",
"9 Donald J. Trump Jared Kushner 515 \n",
"\n",
" sent_text \n",
"0 He had met with President - elect Trump , Kushner and Bannon at Trump Tower in November , 2016 ,... \n",
"1 Trump ’s wealth manager at Deutsche , Rosemary Vrablic , specializes in real estate and is close... \n",
"2 In the final installment , we ’ll detail how Trump ’s son - in - law and White House adviser Jar... \n",
"3 Preet Bharara in Trump Tower on November 30 , 2016 , along with advisor Steve Bannon and Jared K... \n",
"4 The timing of the Deutsche refinancing transaction with Kushner and the subsequent media attenti... \n",
"5 Additionally , Kushner neglected to mention that — subsequent to another meeting with both Flynn... \n",
"6 VEB had provided financing for Trump Tower Toronto — as Kushner surely knew previous to his meet... \n",
"7 October 2016 Trump ’s campaign team announces that Kushner will recuse himself from any involvem... \n",
"8 US Attorney Southern District of New York Preet Bharara meets on the 26th Floor of Trump Tower w... \n",
"9 Donald Trump Jr. sent Kushner an email inviting him to a Trump Tower meeting on June 9 , 2016 wi... "
]
},
"execution_count": 18,
"metadata": {},
"output_type": "execute_result"
}
],
"source": [
"djt_kush_rel_df = show_connecting_sentences(graph, \"Donald J. Trump\", \"PER\", \"Jared Kushner\", \"PER\", sent_dict)\n",
"djt_kush_rel_df.head(10)"
]
},
{
"cell_type": "markdown",
"metadata": {},
"source": [
"### Jared Kushner and Deutsche Bank"
]
},
{
"cell_type": "code",
"execution_count": 19,
"metadata": {},
"outputs": [
{
"data": {
"text/html": [
"| \n", " | src | \n", "dst | \n", "sid | \n", "sent_text | \n", "
|---|---|---|---|---|
| 0 | \n", "Donald J. Trump | \n", "Jared Kushner | \n", "109 | \n", "He had met with President - elect Trump , Kushner and Bannon at Trump Tower in November , 2016 ,... | \n", "
| 1 | \n", "Donald J. Trump | \n", "Jared Kushner | \n", "249 | \n", "Trump ’s wealth manager at Deutsche , Rosemary Vrablic , specializes in real estate and is close... | \n", "
| 2 | \n", "Donald J. Trump | \n", "Jared Kushner | \n", "402 | \n", "In the final installment , we ’ll detail how Trump ’s son - in - law and White House adviser Jar... | \n", "
| 3 | \n", "Donald J. Trump | \n", "Jared Kushner | \n", "411 | \n", "Preet Bharara in Trump Tower on November 30 , 2016 , along with advisor Steve Bannon and Jared K... | \n", "
| 4 | \n", "Donald J. Trump | \n", "Jared Kushner | \n", "417 | \n", "The timing of the Deutsche refinancing transaction with Kushner and the subsequent media attenti... | \n", "
| 5 | \n", "Donald J. Trump | \n", "Jared Kushner | \n", "444 | \n", "Additionally , Kushner neglected to mention that — subsequent to another meeting with both Flynn... | \n", "
| 6 | \n", "Donald J. Trump | \n", "Jared Kushner | \n", "445 | \n", "VEB had provided financing for Trump Tower Toronto — as Kushner surely knew previous to his meet... | \n", "
| 7 | \n", "Donald J. Trump | \n", "Jared Kushner | \n", "464 | \n", "October 2016 Trump ’s campaign team announces that Kushner will recuse himself from any involvem... | \n", "
| 8 | \n", "Donald J. Trump | \n", "Jared Kushner | \n", "468 | \n", "US Attorney Southern District of New York Preet Bharara meets on the 26th Floor of Trump Tower w... | \n", "
| 9 | \n", "Donald J. Trump | \n", "Jared Kushner | \n", "515 | \n", "Donald Trump Jr. sent Kushner an email inviting him to a Trump Tower meeting on June 9 , 2016 wi... | \n", "
\n",
"\n",
"\n",
" \n",
"
\n",
"
"
],
"text/plain": [
" src dst sid \\\n",
"0 Jared Kushner Deutsche Bank 17 \n",
"1 Jared Kushner Deutsche Bank 249 \n",
"2 Jared Kushner Deutsche Bank 402 \n",
"3 Jared Kushner Deutsche Bank 405 \n",
"4 Jared Kushner Deutsche Bank 406 \n",
"5 Jared Kushner Deutsche Bank 407 \n",
"6 Jared Kushner Deutsche Bank 417 \n",
"7 Jared Kushner Deutsche Bank 463 \n",
"8 Jared Kushner Deutsche Bank 464 \n",
"9 Jared Kushner Deutsche Bank 512 \n",
"\n",
" sent_text \n",
"0 ( Eastern District of New York ) has requested records from Deutsche Bank relative to Jared Kush... \n",
"1 Trump ’s wealth manager at Deutsche , Rosemary Vrablic , specializes in real estate and is close... \n",
"2 In the final installment , we ’ll detail how Trump ’s son - in - law and White House adviser Jar... \n",
"3 This “ cooperation agreement ” becomes more pertinent when we consider Jared Kushner ’s relation... \n",
"4 When he first filed the financial disclosure forms mandated for all federal employees , Kushner ... \n",
"5 But at that time , Kushner failed to disclose the $ 285 million refinancing his firm received fr... \n",
"6 The timing of the Deutsche refinancing transaction with Kushner and the subsequent media attenti... \n",
"7 October 2016 Jared Kushner ’s business receives a $ 285 million loan from Deutsche Bank relative... \n",
"8 October 2016 Trump ’s campaign team announces that Kushner will recuse himself from any involvem... \n",
"9 Kushner must have forgotten about the promise he made to recuse himself from contact with any pa... "
]
},
"execution_count": 19,
"metadata": {},
"output_type": "execute_result"
}
],
"source": [
"kush_db_rel_df = show_connecting_sentences(graph, \"Jared Kushner\", \"PER\", \"Deutsche Bank\", \"ORG\", sent_dict)\n",
"kush_db_rel_df.head(10)"
]
},
{
"cell_type": "markdown",
"metadata": {},
"source": [
"## Find path connecting a pair of nodes"
]
},
{
"cell_type": "code",
"execution_count": 20,
"metadata": {},
"outputs": [],
"source": [
"def get_path_between(graph, src_name, src_type, dst_name, dst_type):\n",
" query = \"\"\"\n",
"MATCH (start:%s {ename:'%s'}), (end:%s {ename:'%s'})\n",
"CALL algo.shortestPath.stream(start, end)\n",
"YIELD nodeId, cost\n",
"RETURN algo.asNode(nodeId).ename AS name, cost \n",
" \"\"\" % (src_type, src_name, dst_type, dst_name)\n",
" results = graph.run(query).data()\n",
" path = [x[\"name\"] for x in results]\n",
" return path\n"
]
},
{
"cell_type": "markdown",
"metadata": {},
"source": [
"### Path from Donald J. Trump to Vladimir Putin"
]
},
{
"cell_type": "code",
"execution_count": 21,
"metadata": {},
"outputs": [
{
"name": "stdout",
"output_type": "stream",
"text": [
"['Donald J. Trump', 'Deutsche Bank', 'Vladimir Putin']\n"
]
}
],
"source": [
"djt_putin_link = get_path_between(graph, \"Donald J. Trump\", \"PER\", \"Vladimir Putin\", \"PER\")\n",
"print(djt_putin_link)"
]
},
{
"cell_type": "code",
"execution_count": null,
"metadata": {},
"outputs": [],
"source": []
}
],
"metadata": {
"kernelspec": {
"display_name": "Python (neo4j)",
"language": "python",
"name": "neo4j"
},
"language_info": {
"codemirror_mode": {
"name": "ipython",
"version": 3
},
"file_extension": ".py",
"mimetype": "text/x-python",
"name": "python",
"nbconvert_exporter": "python",
"pygments_lexer": "ipython3",
"version": "3.6.7"
}
},
"nbformat": 4,
"nbformat_minor": 2
}
================================================
FILE: src/genetagger/file_reformatter.py
================================================
# Reformats supplied input file to form parseable by NLTK corpus readers.
def reformat(file_in, file_out, is_tagged):
fin = open(file_in, 'rb')
fout = open(file_out, 'wb')
sent = []
for line in fin:
line = line.strip()
if len(line) == 0:
if is_tagged:
fout.write(" ".join(["/".join([word, tag]) for word, tag in sent]) + "\n")
else:
fout.write(" ".join([word for word in sent]) + "\n")
sent = []
continue
if is_tagged:
word, tag = line.split(" ")
sent.append((word, tag))
else:
sent.append(line)
fin.close()
fout.close()
def main():
reformat("gene.train", "gene.train.blog", True)
reformat("gene.key", "gene.validate.blog", True)
reformat("gene.test", "gene.test.blog", False)
if __name__ == "__main__":
main()
================================================
FILE: src/genetagger/gene.test
================================================
Third , consistent with these data , N - acetylcysteine reduced the stimulatory effect of HGF on stress kinase activities , while p42 / 44 mitogen activated kinase ( MAPK ) was unmodified , suggesting an involvement of c - Jun - N - terminal kinase ( JNK ) and p38 MAPK in HIF - 1 activation .
The Sox gene family ( Sry like HMG box gene ) is characterised by a conserved DNA sequence encoding a domain of approximately 80 amino acids which is responsible for sequence specific DNA binding .
Respiratory parameters suggested that M6G produced less respiratory depression than morphine .
This slow progression through the early G1 - phase resulted in decreased phosphorylation of the RB protein and subsequent delay into the S phase transition .
Responses of TLD Mg2SiO4 : Tb and radiophotoluminescent glass to heavy charged particles and space radiation .
In the meantime , one has succeeded to establish the deammonification processes in a continuous flow moving - bed pilot plant .
An 18 - kb genomic clone including sequences encoding for the two GHS - R variants was isolated .
In the further development of bladder neck suspension according to Stamey - Pereyra , the use of miniature bone anchors received considerable support .
CHAP and the Department of Veterans Affairs .
Finally , a chromogenic method was used , based on thrombin inhibition and the substrate S - 2238 .
As an oral , nontoxic compound with a mechanism of action distinct from that of ABL tyrosine kinase inhibition , FTI SCH66336 shows promise for the treatment of BCR / ABL - induced leukemia .
Recruitment of an RNA polymerase II complex is mediated by the constitutive activation domain in CREB , independently of CREB phosphorylation .
Our results are reassuring and we therefore advise that in patients undergoing free jejunum flap reconstruction of the hypopharyngo - esophageal tract voice restoration should be attempted by placing a voice prosthesis through a secondary tracheo - esophageal puncture and providing intensive speech training .
Regarding gestational risk , 3 , 243 drugs used ( 34 %) belonged to category A risk , 1 , 923 ( 22 . 6 %) to category B , 3 , 798 ( 39 . 7 %) to category C , 289 ( 3 . 0 %) to category D , and 55 ( 0 . 6 %) to category X .
The human ABCG1 gene encodes a member of the ATP - binding cassette ( ABC ) superfamily of transporter proteins and is highly induced when macrophages are incubated with oxysterols .
At the end of each day of migration the pulmonary hemolymph PO2 decreased by 1 - 2 . 5 kPa , but the hemocyanin remained saturated with O2 and the venous reserve was largely unchanged ( O2 > 0 . 4 mmol x l (- 1 )).
We have investigated the role of NGF in regulating gene transcription in PC12 and INS - 1 cells , in order to define if there are NGF - regulated genes per se .
Thus , through a change in conformation upon repair of the 6RG lesion , MGMT switches from a DNA repair factor to a transcription regulator ( R - MGMT ), enabling the cell to sense as well as respond to mutagens .
TaqMan analysis of gene expression following chronic FA treatment showed neither a decrease in the amount of leptin receptor ( Ob - R ) mRNA , nor an increase in the negative regulators of STAT signalling , SOCS3 ( suppressors of cytokine signalling ) or cytokine inducible sequence ( CIS ).
Nine animals served as control animals , whereas 20 animals received a focal arachnoid scar at C1 - C2 , which was produced by placement of a kaolin - soaked fibrin sponge on the posterior surface of the spinal cord .
A comparison of the duplicated Vkappa genes suggests positive selection on the complementarity - determining regions of the duplicated genes by point mutations .
They have not been previously reported as a reaction to i . v . contrast material .
The presence of AS - oligo had no further effect on the FSH - mediated activation of the EB *- mTf - CAT construct but reduced cAMP - mediated activation .
The homologous active - site framework of these enzymes with distinct structures suggests convergent evolution of a common catalytic mechanism .
Additional education and research is needed to provide further direction for intervention and incorporation into practice .
Many of the important genes associated with G1 regulation have been shown to play a key role in proliferation , differentiation and oncogenic transformation and programmed cell death ( apoptosis ).
Drug interactions have been found with drugs that compete for the same CYP450 isoenzymes as statins .
Regulation of laminin beta2 chain gene expression in human cancer cell lines .
Mutation of the NF - kappaB site in the Mdr1b promoter prevents its induction by TNF - alpha .
Effect of heat treatments on the meltability of cheeses .
In vitro binding studies demonstrate that eIF - 5A is required for efficient interaction of Rev - NES with CRM1 / exportin1 and that eIF - 5A interacts with the nucleoporins CAN / nup214 , nup153 , nup98 , and nup62 .
Forced expression of BZAP45 strongly stimulates H4 promoter ( nt - 215 to - 1 )/ CAT reporter gene activity .
Copyright 2001 Academic Press .
The diagnosis of HCV arthritis in patients with positive rheumatoid factor and chronic inflammatory polyarthritis may be difficult .
The UBA domains of RAD23 and DDI1 are required for these interactions .
E47 protein levels remain high until the double positive developmental stage , at which point they drop to relatively moderate levels , and are further downregulated upon transition to the single positive stage .
By Caveman .
These findings suggest that the adapter Gab1 may redirect c - Met signaling through PI3K away from a c - Akt / Pak1 cell survival pathway .
Another mutant , T255A , lost the ability to bind E4orf6 , but unexpectedly , viral late - gene expression was not affected .
However , the N63S mutation in the wild - type VP5 background increased the interaction , as judged by the beta - galactosidase activity , by a factor of 9 relative to when the PR7 mutation was present .
Here we report the isolation and characterization of the forkhead homologue in rhabdomyosarcoma ( FKHR ), a recently described member of the hepatocyte nuclear factor 3 / forkhead homeotic gene family , as a nuclear hormone receptor ( NR ) intermediary protein .
Unlike other progenitor cells of the brain , SVZa progenitor cells have the capacity to divide even though they express a neuronal phenotype .
We previously reported that Tax induced cell cycle progression from G0 / G1 phase to S and G2 / M phases in human T - cell line Kit 225 cells .
Phosphotyrosyl peptides block Stat3 - mediated DNA binding activity , gene regulation , and cell transformation .
In Exp .
Human brain cDNA library screening and 5 ' rapid amplification of cDNA ends yielded full - length DENTT cDNA containing an 1899 - bp open reading frame encoding a predicted 633 - amino - acid protein with four potential nuclear localization signals ( NLSs ) and two coiled - coil regions .
NaeI , a novel DNA endonuclease , shows topoisomerase and recombinase activities when a Lys residue is substituted for Leu 43 .
We used a rev - and RRE - defective HIV type 1 ( HIV - 1 ) molecular clone in complementation experiments to establish a method for the rapid isolation of posttranscriptional regulatory elements from the mammalian genome by selecting for rescue of virus replication .
OBJECTIVES : The objective of this review was to compare the effectiveness , safety and acceptability of the diaphragm with and without spermicide .
DESIGN : Retrospective study .
Considering that the reactor is thoroughly mixed during each discharge and that LD50 = 0 . 9 values are nearly independent of E . coli concentrations in the range of 2 x 10 ( 3 ) < or = E coli / cfu mL (- 1 ) < or = 3 x 10 ( 6 ), we ascribe the nonexponential Pn decay of single - strain E . coli colonies to a shielding phenomenon where inactive cells protect the successively smaller numbers of viable cells in the EHD .
These genes encode a tryptophanyl tRNA , the protein translocase component SecE , the antiterminator protein NusG , and the ribosomal proteins L11 and L1 in addition to PkwR , a putative regulatory protein of the LacI - GalR family .
Body fat distribution was determined by abdominal computed tomography .
The telomerase RNA - protein complex responsible for maintenance of telomeric DNA at chromosome ends , is usually inactive in most primary somatic human cells , but is specifically activated with in vitro immortalization and during tumorigenesis .
This is a challenging task insofar as direct measures of ISF glucose are not readily available .
SELECTION CRITERIA : All randomised controlled trials comparing IUSs with other forms of reversible contraceptives and reporting on pre - determined outcomes in women of reproductive years .
There was a statistically significant correlation between simultaneous weekly average pollen levels in Philadelphia and in Cherry Hill ( Acer , r ( p ) = 0 . 987 , Quercus , r ( p ) = 0 . 645 , Betula , r ( p ) = 0 . 896 , Pinus , r ( p ) = 0 . 732 , Cupressaceae , r ( p ) = 0 . 695 , Poaceae , r ( p ) = 0 . 950 , Ambrosia , r ( p ) = 0 . 903 , and Rumex , r ( p ) = 0 . 572 , P < 0 . 001 ).
Through two novel mechanisms , Arf inhibits the oncoprotein Hdm2 , a negative regulator of p53 .
2 : The dynamic moduli of microcrystalline cellulose .
Such knowledge could advance diagnosis and treatment of the patient and counseling of the affected family .
Here we show that independent of uncertainties in the models , terrestrial planets with dense atmosphere like Venus can evolve into one of only four possible rotation states .
Our results suggest that WASP activates transcription following TCR stimulation in a manner that is independent of its role in Arp2 / 3 - directed actin polymerization .
In contrast , the ubiquitous expression of p19 ( INK4d ) has not been previously described in human or murine B - lineage cells .
This animal model of dystonia appears to be a model of NAD in man from the viewpoint of treatment - response .
These results indicate that evaluation of exposure to S . neurona by WB analysis of serum may be misleading in young horses .
The Delta6CCI virus was extremely attenuated in replication capacity yet retained infectiousness for CEMx174 and MT4 cells .
OBJECTIVE : To determine the association of depressive symptoms with HIV - related mortality and decline in CD4 lymphocyte counts among women with HIV .
Phase II study of paclitaxel and oral etoposide in patients with locally advanced or metastatic non - small cell lung cancer .
Analyses revealed that scale matters above and beyond the effect of quadrat area .
Rind et al .' s study ' s main conclusions were not supported by the original data .
Not Available
Lactate accumulation peak was unaffected by supplementation ( HMB , 8 . 1 +/- 1 . 1 mM ; LEU , 6 . 2 +/- 0 . 8 mM ; CON , 7 . 5 +/- 1 . 3 mM ).
However , the abi1 - 1 gene product has no effect on the ABA suppression of a GA - responsive alpha - amylase gene .
Polyclonal antibodies against the N - terminal part ( amino acids 12 - 363 ) and the C - terminal part ( amino acids 330 - 730 ) of rainbow trout HIF - 1alpha protein recognized rainbow trout and chinook salmon HIF - 1alpha protein in Western blot analysis .
Southern blot analysis of genomic DNA from somatic cell hybrids showed that endothelial - TACC - related cDNA maps to chromosome 10 .
PABP is a modular protein , with four N - terminal RNA - binding domains and an extensive C terminus .
9 . 7 ( 95 % CI : 9 . 6 - 9 . 7 ) micromol / L among women ( P = 0 . 003 ).
The mean waiting time to receive the pancreas transplant was 244 days for SPK and 167 days for PAK recipients ( P = 0 . 001 ).
Zarix expected patient enrollment in Canadian clinical sites to begin in Spring 2001 [ 397955 ], [ 405928 ].
The isoform , designated HDAC9a , is 132 aa shorter at the C terminus than HDAC9 .
Long - range comparison of human and mouse SCL loci : localized regions of sensitivity to restriction endonucleases correspond precisely with peaks of conserved noncoding sequences .
In Saccharomyces cerevisiae , eIF6 is encoded by a single - copy essential gene .
Three patients received additional cycles of 5 - fluorouracil +/- leucovorin as maintenance chemotherapy . RESULTS : Thirty males and 21 females with a median age of 55 years ( range 31 -- 73 years ) were treated .
RESULTS : Within 7 days , all groups re - acquired responding for heroin under CRF at rates similar to their pre - lesion performance .
The application of the biotechnology at the plants for treatment of the surface storm waters from the industrial zone Telychka of the city of Kyiv has allowed the content of petroleum in water dropped to the Dnieper to be constantly reduced 50 - 100 times .
Using immunochemical co - precipitation methods , we also found that the two proteins are bound in vivo .
Utility of OAE screener ( GSI 70 ) for the evaluation of distortion product otoacoustic emissions ] The purpose of this study was to investigate the ability of the OAE screener GSI 70 to evaluate of cochlea function in neonates , infants and adults .
Our results demonstrated that 50 % of the hepatic artery - alone ALT graft showed almost normal structure histologically at 1 month after grafting , with bile secretion preserved .
Mean Hg concentrations in the livers of mice at some sites in Isle Royale are not significantly lower ( P = 0 . 62 ) than Hg concentrations considered by some government agencies to be unhealthy for human consumption .
We show here that the in vitro transcription extract contains a binding activity that is specific for the initiator element and thus may participate in recruiting RNA polymerase II to the SL RNA gene promoter .
The desirability function is based on the search for a global optimum [ D = f ( Y1 , Y2 , ..., Yn )] by the transformation of the measured property to a dimensionless scale for each criterion .
Naltrexone hydrochloride is a synthetic opioid receptor antagonist recently used in efforts to provide rapid opioid detoxification .
We mapped the DGCR6 gene to chromosome 22q11 within a low copy repeat , termed sc11 . 1a , and identified a second copy of the gene , DGCR6L , within the duplicate locus , termed sc11 . 1b .
Proliferative vasculopathy and cutaneous hemorrhages in porcine neonates infected with the porcine reproductive and respiratory syndrome virus .
The child left behind .
Using the two - hybrid system , we show that nonprenylated Rac1 interacts very weakly with Rho - GDI , pointing to the predominant role of protein - isoprene interaction in complex formation .
In contrast , neither I . argentina nor I . theezans exerted any effect on BF or intestinal propulsion .
The region containing both serines is homologous to the N - terminal destruction box of IkappaBalpha , - beta , and - epsilon .
No dominant clinical factor of risk was found , but multiple regression analysis identified age , body surface area , valve size , shop order fracture rate , and manufacturing period as risk factors for OSF .
A novel growth - related nuclear protein binds and inhibits rat aldolase B gene promoter .
Northern blot analysis revealed that mlt 1 is normally expressed in brain , spleen , stom ach , and liver .
NO metabolites were determined by the measurement of nitrate / nitrite ( NOx , micromol / mmol creatinine ) and cyclic guanosine monophosphate ( cGMP , nmol / mmol creatinine ) in plasma and urine .
As a complement to genome - wide mapping and sequencing efforts , it is often important to generate detailed maps and sequence data for specific regions of interest .
The observed phenotypes may be explained by ( i ) a selective disruption of very - low - density lipoprotein secretion due to decreased expression of genes encoding apolipoprotein B and microsomal triglyceride transfer protein , ( ii ) an increase in hepatic cholesterol uptake due to increased expression of the major high - density lipoprotein receptor , scavenger receptor BI , and ( iii ) a decrease in bile acid uptake to the liver due to down - regulation of the major basolateral bile acid transporters sodium taurocholate cotransporter protein and organic anion transporter protein 1 .
Effects of aerosol - vapor JP - 8 jet fuel on the functional observational battery , and learning and memory in the rat .
In mouse , Mmip1 ( Mad member interacting protein 1 ) and Smc3 share 99 % sequence identity and are products of the same gene .
To identify the important cis - DNA regulatory element ( s ) involved in the tissue -, region -, and cell - specific expression of the mE - RABP gene , the 5 - kb DNA fragment was sequenced .
Regional blood blow was measured by means of microspheres in predefined regions of the C6 , T11 , and L6 vertebrae .
Breast cancer risk assessment : Who holds the magic crystal ball ?
The frameshift initiated by ADEx2 is believed to alter the regular coding sequence , acting as a loss - of - function ASIP mutation .
CONCLUSIONS : Adding MMF , a potent topical corticosteroid , to an emollient cream is statistically significantly more effective than emollient cream alone in reducing acute radiation dermatitis .
Copyright 2001 Academic Press .
CONCLUSIONS : Although the levels of oxLDL antibodies might be modified in early hypertension , once advanced coronary artery disease has developed the presence of hypertension does not affect anti - oxLDL levels .
As an application of reverse genetics , we introduced one nucleotide change ( UCU to ACU ) to immediate downstream of the RNA - editing site of the V gene in the full - length hPIV2 cDNA and were able to obtain infectious viruses [ rPIV2V (-)] from the cDNA .
At both companies sites Salmonella enteritidis and Salmonella typhimurium Tr104 were also isolated occasionally from various locations .
Most yeast peroxisomal matrix proteins contain a type 1C - terminal peroxisomal targeting signal ( PTS1 ) consisting of the tripeptide SKL or a conservative variant thereof .
Tumor - like accumulation on Tl - 201 SPECT in subacute hemorrhagic cerebral infarction .
WRN helicase resolves alternate DNA structures including tetraplex and triplex DNA , and Holliday junctions .
The increase in number of terminal hairs , which are defined as hairs more than 60 microm in diameter , in the designated area ( 0 . 5 cm square = 0 . 25 cm2 area ) of the procyanidin B - 2 group subjects after the 6 - month trial was significantly greater than that of the placebo control group subjects ( procyanidin B - 2 , 1 . 99 +/- 2 . 58 ( mean +/- SD )/ 0 . 25 cm2 ; placebo , - 0 . 82 +/- 3 . 40 ( mean +/- SD )/ 0 . 25 cm2 ; P < 0 . 02 , two - sample t test ).
SKP1 - SnRK protein kinase interactions mediate proteasomal binding of a plant SCF ubiquitin ligase .
Based on the hypothesis that evolutionarily conserved regions are functionally important and likely to interact with coactivators , we compared the amino acid sequence of C / EBPalpha from different species ( frog to human ) and identified four highly conserved regions ( CR1 - CR4 ) within the transactivation domain .
Colorectal cancer was shown to disproportionately overburden Ashkenazi Jews , who may also be at increased risk for ovarian , pancreatic and stomach cancer , and non - Hodgkin ' s lymphoma .
Percentages of recovery for overload and dilution tests were between 87 and 120 %.
This shows that in situations of separated breaks , NHEJ deficiency leads to genomic rearrangements , in agreement with chromosomal studies .
Copyright 2001 S .
After nerve injury , the nociceptive responses through type I neurons , which are polymodal C - fibers and drive NK1 - receptor mechanisms in spinal pain transmission , were completely lost , but without changes in type II ones , which are polymodal C - fibers and drive NMDA receptor - mechanisms , while type III ones , which are capsaicin - insensitive ( possibly A - fibers ) and drive NMDA - receptor mechanisms , were markedly enhanced .
SV1 has a 33 - amino acid insert in the S1 transmembrane domain that does not alter S1 overall hydrophobicity , but makes the S0 - S1 linker longer .
A variety of receptor - mediated signaling pathways are controlled by both positive and negative extracellular regulators .
A 20 - base pair oligonucleotide containing this nonamer confers up - regulation by hypoxia and inhibition by unsaturated fatty acids when placed upstream of a heterologous promoter in a lacZ reporter construct .
Our results indicate that D ( 4 ) and D ( 2L ) receptors activate the ERK kinase cascade by first mobilizing signaling by the PDGF receptor , followed by the subsequent activation of ERK1 / 2 by pathways associated with this receptor tyrosine kinase .
Raes , P .
Finally , we compared the differential screening techniques in terms of sensitivity , efficiency and occurrence of false positives .
C / EBPbeta LIP overexpressing HC11 cells did not express beta - casein mRNA ( mammary epithelial cell differentiation marker ) in response to lactogenic hormones .
NF - kappaB is involved in the regulation of CD154 ( CD40 ligand ) expression in primary human T cells .
Subacute diencephalic angioencephalopathy ( SDAE ) is a rare and fatal disease of unknown etiology that involves the thalami bilaterally .
NGF elicits a more delayed and sustained ERK phosphorylation than EGF , consistent with previous reports .
TBARS levels , oxygen - radical absorbing capacity assay and AFR release assessed by electron paramagnetic resonance ( EPR ) were used to explore the existence of oxidative stress in diabetes .
Pulmonary vein varix in association with bilateral pulmonary vein stenosis .
Derivation and initial characterization of a mouse mammary tumor cell line carrying the polyomavirus middle T antigen : utility in the development of novel cancer therapeutics .
The images showed rapid , predominantly urinary excretion of 99mTc ciprofloxacin , with low to absent brain , lung and bone marrow uptake and low liver uptake and excretion .
Thus , the anti - interferon functions of vIRF - 2 may contribute to the establishment of a chronic or latent infection .
Topological and mutational analysis of Saccharomyces cerevisiae Ste14p , founding member of the isoprenylcysteine carboxyl methyltransferase family .
Two remotely situated exons within the complement C3 gene locus encode an alternate 5 ' end and proximal ORF under the control of a bidirectional promoter .
Although there was a high correlation between sap flux densities registered by the old and new sensors , significant differences in sap flux densities between the duplicated sensors were detected .
Their numbers have regularly increased since the mid - 1970s .
The hcKrox gene family regulates multiple extracellular matrix genes .
NB - 506 completely inhibits the capacity of topoisomerase I to phosphorylate , in vitro , the human splicing factor 2 / alternative splicing factor ( SF2 / ASF ).
Recent studies using isolated rat adipocytes and chemically synthesized PIG compounds point to IRS1 / 3 tyrosine phosphorylation by p59Lyn kinase as the site of cross - talk , the negative regulation of which by interaction with caveolin is apparently abrogated by PIG .
To investigate the effects of exogenous hyaluronic acid , the development of port - site metastasis was examined using mouse adenocarcinoma cell - line colon 26 cells .
METHODS : Thyroid status was measured at baseline ( 1990 - 93 ), through assessment of serum antibodies to thyroid peroxidase ( TPO - Abs , positive : > 10 IU / ml ), serum TSH levels , and when TSH was abnormal (< 0 . 4 or > 4 . 0 mU / l ), serum thyroxin levels ( T4 ).
Mechanical ventilation in control lungs produced a 47 % decrease in chord compliance , an increase in lung lavage levels of tumor necrosis factor ( TNF )- alpha ( 722 +/- 306 pg / ml ), interleukin ( IL )- 1beta ( 902 +/- 322 pg / ml ), and macrophage inflammatory protein - 2 ( MIP - 2 ) ( 363 +/- 104 pg / ml ) as compared with low levels of cytokines detected in preventilation data , and no change in percentage of surfactant large aggregates ( LA ).
Autoregulation enables different pathways to control CCAAT / enhancer binding protein beta ( C / EBP beta ) transcription .
In the past decade , there have been enormous advances in the use of Bayesian methodology for analysis of epidemiologic data , and there are now many practical advantages to the Bayesian approach .
In strains lacking tup11 and tup12 , the atf1 - pcr1 transcriptional activator continues to play a central role in fbp1 - lacZ expression ; however , spc1 MAPK phosphorylation of atf1 is no longer essential for its activation .
Single amino acid substitutions at the acyl - CoA - binding domain interrupt 14 [ C ] palmitoyl - CoA binding of ACBP2 , an Arabidopsis acyl - CoA - binding protein with ankyrin repeats .
RESULTS : Sixty per cent of African Americans exposed in 26 community outbreaks were TST positive compared to only 40 % of whites following comparable exposures .
For immunological methods , identification of such antigens with intermolecular variability , e . g ., the structural aescin analogs , is of unknown validity .
It was found that intrathecal administration ( i . t .) of D2 receptor agonist LY171555 or D1 / D2 receptor agonist apomorphine increased pain threshold and had a potentiating effect on AA .
Interactions between the checkpoint abrogator UCN - 01 and several pharmacological inhibitors of the mitogen - activated protein kinase ( MAPK ) kinase ( MEK )/ MAPK pathway have been examined in a variety of human leukemia cell lines .
Analysis of regulatory regions in the promoter of the ctr4 (+) copper transporter gene in fission yeast Schizosaccharomyces pombe reveals the identity of a conserved copper - signaling element ( CuSE ), which is recognized by the transcription factor Cuf1 .
However , during our work with a replication - deficient virus expressing the ASF / SF2 splicing factor from a progesterone antagonist - inducible gene cassette , we discovered that ASF / SF2 was expressed at a significant level in the 293 producer cell line , even in the absence of inducer .
This study suggests that PSP is more common than previously considered , is commonly misdiagnosed and that the majority of cases are not initially referred to neurologists .
Between 1967 and 1994 , 495 patients underwent surgery for primary PTC at the Department of Surgery , Helsinki University Central Hospital .
The described results show that DTD is fast , simple , and easy to automate ; requires only a small amount of sample ( approximately 50 mg ); and affords quantitative information about the main groups of compounds present in cheeses .
Srb10 is a physiological regulator of Gcn4 stability because both phosphorylation and turnover of Gcn4 are diminished in srb10 mutants .
The promoter activity of the proximal region was found to be restricted to a subset of prestalk cells .
Two nuclear medicine physicians blinded to the surgical findings interpreted all available images and various Tc - 99m MIBI image combinations at 15 minutes alone ; 15 minutes and 2 hours , 15 minutes and 4 hours ; and 15 minutes and 2 and 4 hours each with and without correlative pertechnetate thyroid imaging .
We demonstrated that , under serum - starved conditions , KMS - 11 and OPM - 2 cells express appreciable levels of phosphorylated FGFR3 mutants indicating a constitutive activation of the Y373C and K650E receptors ; the addition of the aFGF ligand further increased the level of receptor phosphorylation .
Identical effects were obtained when inhibitors and dominant negative mutants were tested on the - 29 to + 139 bp region of the cyclin D1 promoter .
In this paper the tyrosine dephosphorylating enzymes , the protein - tyrosine phosphatases ( PTPs ), are studied which can be grouped into two subfamilies , the soluble PTPs and the receptor PTPs ( RPTPs ).
Coexposure to FP also resulted in a more pronounced and sustained activation of the mitogen - activated protein kinase kinase / extracellular signal - regulated protein kinase cascade after PMA treatment , although disruption of this pathway by the mitogen - activated protein kinase kinase 1 inhibitor U0126 did not prevent potentiation of apoptosis .
The LA 50s derived from this combined data when compared with our earlier series from 1965 to 1970 also did not show a significant change in mortality .
Most patients harboring metronidazole - and clarithromycin - resistant strains were eradicated at an equal rate by each of the three regimens .
Responses of single - unit carotid body chemoreceptors in adult rats .
Thus , MKK7 is an essential and specific regulator of stress - induced SAPK / JNK activation in mast cells and MKK7 negatively regulates growth factor and antigen receptor - driven proliferation in hematopoietic cells .
The N - terminal portion of Notch ( IC ) inhibited p50 DNA binding and interacted specifically with p50 subunit , not p65 of NF - kappaB .
To account for this observation , other possible causes include increased CSF pulsation in children creating motion artifact , changes in arterial oxygen concentration intrinsic to propofol or related to the supplemental oxygen normally administered , or changes in CSF protein levels related to propofol binding to proteins for uptake into CSF .
Molecular cloning and characterization of OsPSK , a gene encoding a precursor for phytosulfokine - alpha , required for rice cell proliferation .
The present study was initiated to explore the potential of a hybrid biological reactor , combining trickling filter ( TF ) and activated sludge process ( ASP ), to treat wastewater containing trichloroethylene ( TCE ) at ambient temperature at different hydraulic retention time ( HRT ).
If you think education is expensive -- try ignorance -- Bok ' s Law .
The COD and color removals were both more than 90 % when FeCl3 was used as the coagulation ( dosages of two - step coagulation were 0 . 031 and 0 . 012 mol / L respectively ) after a ferrous hydrogen peroxide oxidation pretreatment at a H2O2 dosage of 0 . 06 mol / L .
An element within the 5 ' untranslated region of human Hsp70 mRNA which acts as a general enhancer of mRNA translation .
The selective alteration of the genome using Cre recombinase to target the rearrangement of genes flanked by LOX recognition sequences has required the use of two separate genetic constructs in trans , one containing cre and the other containing the gene of interest flanked by LOX sites .
It has been suggested that members of this protein family exhibit both prolyl isomerase and chaperone activity .
Newcastle disease antibody titre is dependent on serum calcium concentration .
In three cases ( 21 . 4 %), the MR imaging was interpreted as negative , but microscopic tumor was shown around seroma on reexcision .
2 were nonviable , and the mutant Vp1s unexpectedly failed to localize to the nucleus though Vp2 and Vp3 did , suggesting that the mutated NLS1 acted as a dominant signal for the cytoplasmic localization of Vp1 .
Compared with normal control subjects , all 74 TOF patients had decreased systolic and diastolic myocardial velocities and a longer isovolumic relaxation time .
The corresponding orifice voltages for the three instruments were 20 / 50 / 80 V ( API 365 ), 30 / 90 / 130 V ( API 2000 ) and 40 / 80 / 120 V ( API 3000 ).
We compared previously the methylation status between normal liver and liver tumors in SV40 T / t antigen transgenic mice ( MT - D2 mice ) using Restriction Landmark Genomic Scanning for Methylation ( RLGS - M ) and identified several loci / spots that appeared to be methylated frequently in liver tumors .
We have cloned a novel mouse protein , TAF ( II ) 140 , containing an HFD and a plant homeodomain ( PHD ) finger , which we demonstrated by immunoprecipitation to be a mammalian TFIID component .
3D image - processing permits to analyse ultrasound data interactively in three orthogonal planes ( section mode ) or in realistic 3D views ( rendering mode ).
A proposal of 50 performance indicators divided into five different groups is presented here , namely structural indicators , operational indicators , water and service quality indicators , personnel indicators and economic indicators .
These analyses re - open the question whether all the CesA genes encode cellulose synthases or whether some of the sub - class members may encode other non - cellulosic ( 1 --> 4 ) beta - glycan synthases in plants .
The relationship of the factor V Leiden mutation or the deletion - deletion polymorphism of the angiotensin converting enzyme to postoperative thromboembolic events following total joint arthroplasty .
In contrast , exogenous PTHrP1 - 34 and 1 - 86 peptides did not significantly affect IL - 8 production ; moreover , PTHrP - neutralizing antibodies did not inhibit the production of IL - 8 by transfected PTHrP .
Furthermore , this kinase - deficient mutant inhibited 2 - MeSADP - induced caspase - 3 stimulation and the associated decrease in cell number .
Against gram - positive organisms , E - 4767 and E - 5065 were , in general , eight - and fourfold more active than tosufloxacin , which is the most potent of the reference compounds .
The results presented here show that AR1 of the promoter - proximal CAP subunit was required for papBA transcription even in the absence of the histone - like protein H - NS .
CONCLUSIONS : Under current immunization practices , the authors estimate that nearly 13 , 000 Asian and Pacific Islander children living in the United States today will become infected with HBV in the future , resulting in more than 600 liver carcinoma deaths .
METHODS : A structured interview was undertaken at the time of initial consultation and at subsequent 1 - year intervals regarding type of BHS , frequency of spells , associated phenomenon , sequelae , family history , and age at termination of spells .
Cell .
Rapid evolution of the DNA - binding site in LAGLIDADG homing endonucleases .
These mutations , when placed in a wild - type fliF background , had no mutant phenotype .
Inhibition of JNK1 and ERK kinase activities either by expression of the dominant negative mutant JNK1 or by treatment with a selective chemical inhibitor of ERK ( PD098059 ) substantially abrogates the UV induction of the GADD45 promoter .
At termination ( gd 20 ), confirmed - pregnant females ( 21 to 25 per group ) were evaluated for clinical status and gestational outcome ; live fetuses were examined for external , visceral , and skeletal malformations .
In mammals , the transcriptional repressors in the Wnt pathway are not well defined .
Intravenous L - carnitine treatment increased plasma carnitine concentrations , improved patient - assessed fatigue , and may prevent the decline in peak exercise capacity in hemodialysis patients .
The Van der Hoeve ' s syndrome lesions as poorly mineralized , with low calcium salt and apparent increase of phosphates .
A computerized method of determining the focal point of electrical activity in the pallidum of parkinsonian patients was developed using on - line quantitative physiological data analysis .
The first hypothesis was supported in the sense that stimulus differences might affect behaviour even without their successful attentive processing in normal participants .
We interpret these data as further evidence that interaction with a small GTPase is the main regulatory function of the C1 domain in yeast .
This effect was observed in the absence of de novo protein synthesis and was independent of histone deacetylase activity .
Mutation analyses identified the cobalt - responsive sequences as the stress - response elements ( StREs ).
In order to quantify these effects , tests were conducted in the NASA MSFC Neutral Buoyancy Simulator , in the NASA KC - 135 in parabolic flight , and in space with the EASE program during the Shuttle Atlantis mission 61 - B .
OBJECTIVE : To investigate the association between complete congenital heart block ( CCHB ) in the fetus and adult disease .
The present chemotherapy of AE is based on the administration of benzimidazole carbamate derivatives , such as mebendazole and albendazole .
The uptake of fluorine - 18 fluorodeoxyglucose ( F - 18 FDG ) by a malignant tumor depends on the blood glucose level .
Deterministic effects .
DESIGN : A retrospective chart review of 9 , 322 patients undergoing surgical procedures in the period January 1993 to December 1998 .
Peripheral and preemptive opioid antinociception in a mouse visceral pain model .
METHODS : We studied the clinical benefit of depth - dependent RR , nonuniform AC using a scanning line source , and scatter correction ( photon energy recovery [ PER ]) compared with filtered backprojection alone .
Cloning and characterization of the murine beta ( 3 ) integrin gene promoter : identification of an interleukin - 4 responsive element and regulation by STAT - 6 .
DNA binding assays confirmed the interference of p30 ( II ) with the assembly of CREB - Tax - p300 / CBP multiprotein complexes on 21 - bp repeat oligonucleotides in vitro .
Transient transfections showed that a single mutation ( 556M ) decreased TBLV enhancer activity at least 20 - fold in two different T - cell lines .
In conclusion , tube size estimated by Cole ' s formula tends to be smaller than practically appropriate tube size for pediatric cardiac anesthesia , and therefore we suggest new formula to estimate the tube size .
Thus , in T47D breast carcinoma cells , IL - 6 acts in synergy with EGF receptor autocrine activity to signal through the MAPK / PI3K pathways .
Nerve growth factor ( NGF ) and retinoic acid ( RA ) exert important actions on PC12 cells .
HexA71 negatively affects RpoS , as the levels of this alternative sigma factor are higher in the HexA - mutant than in the HexA + strain .
Moreover , elderly men with bioavailable estradiol levels below the median [ 40 pmol / liter ( 11 pg / ml )] had significantly higher rates of bone loss and levels of bone resorption markers than men with bioavailable estradiol levels above 40 pmol / liter .
The histamine H1 receptor antagonists ( antihistamines ) are an important class of medications used for the relief of common symptoms associated with hyperhistaminic conditions occurring in children and adults .
The production of ceramide is emerging as a fixture of programmed cell death .
The flux rates of p - toluidine decreased as the pH value in the donor solution increased .
Managing HIV .
BACKGROUND : There is increasing interest on the part of investigators and the public at large in finding ways to study and improve treatments for the seriously mentally ill without exposing such individuals to unnecessary risks .
Multidrug resistance in Saccharomyces cerevisiae mainly results from the overexpression of genes coding for the membrane efflux pumps , the major facilitators and the ABC binding cassette transporters , under the control of key transcription regulators encoded by the PDR1 and PDR3 genes .
Serum PTH tended to increase in the WL group but not in the WM group ( P < 0 . 06 ).
Bandshift experiments demonstrate that BmHR3A binds specifically to RORE ( Retinoic acid - related Orphan receptor Response Element )- like sequences in the promoters of both genes , thus suggesting a direct role for BmHR3A in regulating the expression of BmGATAbeta and ESP genes during vitellogenesis .
Efficacy of first - generation Cavermap to verify location and function of cavernous nerves during radical prostatectomy : a multi - institutional evaluation by experienced surgeons .
During most of the cell cycle , separase is kept inactive by binding to an inhibitory protein called securin .
In conclusion , obesity , alcohol intake , and multimetabolic disorders were determined to be independent predictors for the development of hyperuricemia .
This study examined the role of cholesteryl ester transfer ( CET ), cholesteryl ester transfer protein ( CETP ) activity , and phospholipid transfer protein ( PLTP ) activity in the increased prevalence of coronary artery calcification ( CAC ) in diabetic subjects compared with nondiabetic subjects and in the loss of the sex difference in CAC in diabetes .
In the mouse , both genes reside in the syntenic region 8E1 on chromosome 8 .
We observed NP / NMP4 / CIZ expression in osteocytes , osteoblasts , and chondrocytes in rat bone .
Following baseline clinical examination and initial periodontal therapy , 32 patients received mucogingival surgery with free gingival grafts for treatment of insufficient attached gingiva .
In contrast , the failure of the QKTT motif and TGN46 cytoplasmic tail to induce steady - state ER localization of vesicular stomatitis virus glycoprotein ( VSVG ) chimeras in HeLa and NRK cells indicates that significant differences in early secretory trafficking also exist .
We previously showed that this proteolysis 1 ) can be acutely promoted by the phorbol ester phorbol 12 - myristate 13 - acetate ( PMA ), 2 ) requires a metalloprotease activity , 3 ) generates both shed GHBP and a membrane - associated GHR transmembrane / cytoplasmic domain remnant , and 4 ) results in down - regulation of GHR abundance and GH signaling .
Our data indicate that SIP1 is required to confine XBra gene expression to the mesoderm .
Changes of the DB sequence without affecting the postulated stem structure led to drastic losses of translation efficiency .
This subfamily of genes all have a single ATP - binding domain at the N - terminus and a single C - terminal set of transmembrane segments .
Subsequently , these coordinates must be interpreted to define particular tissues and organs .
The cyclins bind to and activate the CDK , which leads to phosphorylation ( and then inhibition ) of the tumor suppressor protein , pRb . pRb controls commitment to progress from the G1 to S phase , at least in part by repressing the activity of the E2F transcription factors known to promote cell proliferation .
The mean serum creatinine level did not change during the first 6 months after withdrawal of MMF .
The severity of pathologic changes increased with the magnitude of percussion .
Patients with antibody peaks , defined as fivefold or higher increase in antibody titer compared to the lowest antibody titer over the course of GBS , had higher disability scores during the first two weeks of GBS and a worse clinical outcome ( anti - GM1 IgG and anti - GD1a IgM antibody peaks ) and axonal damage ( anti - GD1a IgM antibody peaks ), compared to patients without peak antibody titers .
At 20 days ( D ) and at 3 months post - TBI , irradiated rats had a significantly lower percentage of avoidance than controls but no statistical difference was found at 5 months post - TBI . b / Two - way avoidance test : this test was performed only after TBI .
TE - 671 cells that were transfected with cAMP response element mutant constructs demonstrated a diminished basal activity of the GnRH - II promoter .
The severity of clinical course was expressed by means of SOFA score ( group A 0 . 3 - 1 - 1 . 3 point , group B 2 . 2 - 2 . 9 - 2 . 6 point , group C 7 . 4 - 8 . 3 - 7 . 7 point ) and APACHE II score ( group A 3 . 7 - 7 . 6 - 8 . 1 point , group B 8 . 6 - 11 . 1 - 10 . 5 point , group C 16 . 3 - 15 . 2 - 14 . 3 point ).
A novel potential effector of M - Ras and p21 Ras negatively regulates p21 Ras - mediated gene induction and cell growth .
Promoter transcriptional activity was determined for a wide 5 ' portion of the human annexin A5 gene , from bp - 1275 to + 79 relative to the most 5 ' of several discrete transcription start points .
Structure of the EMAPII domain of human aminoacyl - tRNA synthetase complex reveals evolutionary dimer mimicry .
Adding 10 mmol SDS / l led to transient inhibition of acidification , metal solubilization and sulfur oxidation .
Competition electrophoretic mobility shift and immunoshift assays confirmed that NF1 factors present in nuclear extracts of HeLa and CV - 1 cells bind to the BKV - MLP .
Northern and Western blot analyses demonstrated that Graf2 is expressed in several tissues , with the highest expression in skeletal muscle .
A minimal ER3 sequence of DNA was further demonstrated to function as a FXR HRE and was bound in vitro by FXR - expressing yeast extracts .
In Ka13 cells , CoCl ( 2 ) stimulated expression of a luciferase reporter gene under the control of a 15 - kilobase pair mouse ho - 1 promoter ( pHO15luc ).
Nine strains were subtyped as Camp . jejuni subsp . jejuni biotype II and the remaining ones as biotype I .
The Ig - related , typical metazoan , module is classified to the disulphide lacking Ig members and represents the phylogenetic earliest member of this group .
In budding yeast , this latter checkpoint response involves the proteins Mad1 , 2 , 3 , Bub1 and Bub3 , whose vertebrate counterparts localize to unattached kinetochores .
We investigated the production of hyaluronan ( HA ) and its effect on cell motility in cells expressing the v - src mutants .
Oral supplementation of L - arginine significantly increased plasma L - citrulline , which indicated enhancement of NO production .
We can classify antibiotics into two groups based on initial bactericidal activity against P . aeruginosa ; one class is antibiotics having rapid initial killing such as AMK , IPM and PAPM , the other is CAZ , MEPM showing slow initial killing .
The presence of truncated receptor isoforms in diverse species suggests that these proteins may have important functional roles in regulating EGFR activity .
Of its gene products , E6 binds to and inactivates p53 tumor suppressor protein by ubiquitin / proteasome - dependent degradation .
Low affinity binding of Rab6A - GTP was also observed ( K ( d ) = 16 microm ), whereas Rab1B , - 5 , - 7 , - 8 , or - 11A did not bind .
( 1997 ) Nature 387 , 370 - 376 )], we suggest that the metal fluoride ions replaced phosphate at the two ATP - binding sites of the iron protein , Kp2 .
A 1 - base pair mismatch within the corresponding region of the CYP3A4 gene was sufficient for a differential enhancer activity .
AIMS : To establish a baseline and intraindividual fluctuations of the tumour markers CEA , CA 50 and CA 242 in patients cured from colorectal cancer , and to test the hypothesis that serum concentrations and intraindividual fluctuations do not differ from the concentrations in cancer - free individuals .
Substitution of serine residues at the C - terminus indicated that loss of phosphorylation sites did not appear to have any effect on transcription and replication .
Molecular analysis of the pRA2 partitioning region : ParB autoregulates parAB transcription and forms a nucleoprotein complex with the plasmid partition site , parS .
Tumor cell lines transduced at an MOI of 8 for 3 days led to > 90 % gene transfer efficiency .
No ISREs could be identified in the mouse promoter .
GABA ( B ) R1g was expressed in both brain and peripheral tissues .
Granulocyte colony - stimulating factor ( G - CSF ) administration in vivo has been shown to improve the defence mechanisms against infection by different microbes .
Use of a dual - pulse lithotripter to generate a localized and intensified cavitation field .
The best regression model for predicting changes in the WCXR included time to first positive culture and antibody titer for Pa elastase .
RESULTS : The parameters SF2 and plating efficiency were stable throughout the 4 - year test period .
The process has been applied to the river reclamation in Yangpu District of Shanghai City , China .
Multiple regression analysis performed between these long - term abiotic factors and nymphal abundance in positive sites showed high relationship ( R2 coefficients ) for every habitat category and explained > 50 % of the variation in tick abundance .
The v - Src SH3 domain facilitates a cell adhesion - independent association with focal adhesion kinase .
Of the six cases of malignant polyposis , none were identified using CT , and only two were diagnosed by small bowel follow - through .
Right LHR ( R - LHR ) provided the best interobserver and intraobserver reproducibility .
We also reported the identification of three corresponding alternative first exons and an intronic promoter in the human PDE5A gene .
Of major concern to food processors is the inadvertent cross - contact of food products with allergenic residues , which could result in potentially life - threatening reactions in those with a food allergy .
Diffuse myalgias were more frequent in patients with than without an MMF lesion at deltoid muscle biopsy ( P < 0 . 0001 ).
Functional analysis of various PTP - deficient DT40 B cell lines stably expressing wild - type chimeric Fc gamma RIIB1 - PECAM - 1 receptor indicated that cytoplasmic Src homology 2 - domain - containing phosphatases , SHP - 1 and SHP - 2 , were both necessary and sufficient to deliver inhibitory negative regulation upon coligation of BCR complex with inhibitory receptor .
Subtraction hybridization identified melanoma differentiation associated gene - 7 ( mda - 7 ), as a gene induced during these physiological changes in human melanoma cells .
A rare case of primary group A streptococcal peritonitis .
Among individuals , however , changes were strongly correlated with ACR levels at baseline .
RESULTS : The subjects in the augmented feedback group significantly reduced their peak vertical ground reaction force in both post - test conditions ( 2 - minute post - test reduction , 0 . 85 +/- 0 . 62 ; 1 - week post - test reduction , 0 . 74 +/- 0 . 58 ) as compared to the sensory , control I , and control II feedback groups .
The blood levels of lactate , pyruvate and amino acids were not elevated .
Histological examination showed lichenoid changes , acantholytic blister formation and apoptotic keratinocytes .
Enantiomer separation of venlafaxine and O - desmethylvenlafaxine in human plasma .
Paul Monagle addresses the epidemiology of neonatal thrombosis outside of the central nervous system in both arterial and venous locations , and those that occur in utero .
The MSL complex is specifically localized on the male X chromosome to increase its expression approximately 2 - fold .
Effects of a booster dose of tetanus toxoid after different primary courses of vaccination : implications on the use of immune globulin .
Our results suggest that the C - terminal region of Crk contains negative regulatory elements important for both Abl and FAK dependent signal pathways , and offers a paradigm for an autoinhibitory region in the SH3 linker / C - terminal SH3 domain .
The distribution of red rice cultivation in Sri Lanka is coincident with the HIDD villages .
Prophylactic lymph node dissection or radiation therapy to the nodal chain may decrease local recurrence but does not consistently affect overall survival .
Secretion of interleukin - 8 , RANTES , macrophage inflammatory protein 1alpha , and 10 - kappaDa IFN - gamma - inducible protein were increased in differentiating keratinocytes by E6 .
CONCLUSIONS : ChromaFlo - enhanced IVUS demonstrates colorized blood flow inside the vessel lumen , which is helpful in distinguishing echolucent disease from luminal blood flow and can also be used to perform peripheral interventions in patients with renal failure or allergy , avoiding the use of contrast media .
Additional factors such as advanced age , concomitant use of corticosteroids or anticoagulants , prior ulcer complications and co - morbid diseases may further increase the risk of bleeding .
CONCLUSIONS : Using icodextrin - based instead of glucose - based PD fluids can largely reduce the formation of Amadori albumin and AGEs .
A central finding is the identification of a GC - rich sequence in the - 99 /- 91 Cp region that is essential for oriPI - EBNA1 - independent as well as oriPI - EBNA1 - dependent activity of the promoter .
Furthermore , SB203580 inhibited LPS - induced activation of Sp1 , as well as the promoter activity in cells transfected with a plasmid containing the Sp1 consensus sequence .
A new echocardiographic technique is described with a conventional M mode , digitalised 2D and tissular Doppler which has a comparable ability to identify the anomalous pathways of electric conduction using a non - invasive method .
Is clopidogrel superior to aspirin in secondary prevention of vascular disease ? The cornerstone in clinical evidence of the relative efficacy of thienopyridines ( clopidogrel , ticlopidine ) versus aspirin in the secondary prevention of vascular disease is the Clopidogrel versus Aspirin in Patients at Risk of Ischaemic Events trial .
The role of the Vp1 DBD during infection was investigated by taking advantage of NLS phenotypic complementation ( N .
The probability of treatment with lamotrigine being maintained for six months was 86 %, for twelve months 61 % and for three years 31 %.
Recent advances have shown that volatile sulfur is a result of ecological interactions and transformation processes through planktonic food webs .
OsBBPI was found to be rapidly induced in rice seedling leaf in response to cut , exogenous jasmonic acid ( JA ), and two potent protein phosphatase 2A ( PP2A ) inhibitors , cantharidin ( CN ) and endothall ( EN ), in a light / dark -, time - and dose - dependent manner ; this induction was completely inhibited by cycloheximide ( CHX ), indicating a requirement for de novo protein synthesis in its induction .
Analysis of ace2Delta cells reveals that Ace2p is required for cell separation but not for polarized growth .
The purpose of this investigation was to study the morphological characteristics of the fibrous tissue capsule resulting from the implantation of aluminum calcium phosphate ( ALCAP ) and hydroxyapetite ( HA ) bioceramics .
The event rate in patients with chronic Irr - rMFP or Un - nrMFP was markedly higher than it was in those with Rev - rMFP or Sta - nrMFP .
In summary , we conclude that the adenoviral oncoprotein E1A activates transcription from the endogenous AP - 2alpha gene , an effect that involves transcriptional derepression of the AP - 2alpha promoter by interaction of E1A with the AP - 2rep corepressor CtBP1 .
Unusual two - domain arginine kinases ( AKs ) arose independently at least two times during molecular evolution of phosphagen kinases : AKs from the primitive sea anemone Anthopleurura japonicus and from the clam Pseudocardium sachalinensis .
Mutagenesis of SNT1 ( IRS ) CX identified three classes of effector motifs within SNT critical for both sustained ERK activation and neuronal differentiation : 1 ) four phosphotyrosine motifs that mediate recruitment of Grb2 , 2 ) two phosphotyrosine motifs that mediate recruitment of Shp2 , and 3 ) a C - terminal motif that functions by helping to recruit Sos .
CONCLUSIONS : Our meta - analysis of randomized controlled trials of HRT noted a statistically significant reduction in nonvertebral fractures .
However , C4B proteins encoded by monomodular short genes may have relatively higher concentrations than those from long C4A genes .
CSR is directed to specific heavy chain isotypes by cytokines and B cell activators that induce transcription from the unrearranged , or germline ( GL ), C ( H ) region genes .
The patterns of early mRNA and protein expression in these seven mutants were examined , and it was found that mutation of the T '( 135 ) acceptor site resulted in the utilization of cryptic splice sites and the generation of new T ' species .
Mutational analysis showed that the U - box , like the RING finger in other proteins , forms the physical basis for the interaction with E2 enzymes .
GafChromic ( MD - 55 - 2 ) radiochromic film has become increasingly popular for medical applications and has proven to be useful for brachytherapy dosimetry .
The 438 bp EcoRI fragment , which was detected by Southern hybridization , reveals an open reading frame which encodes a protein of 103 amino acids .
Furthermore , hormonal regulation of G ( 1 ) gene transcription can occur even without additional activation of the Mek - Erk1 / 2 pathway by estrogen receptors .
In mammalian tissue culture cells , overexpression of any of the four mouse deltex homologs suppressed the transcriptional activity of E47 , a basic helix - loop - helix ( bHLH ) protein , in a manner similar to suppression by an activated form of human Notch1 or human DTX1 .
The authors undertook a retrospective analysis of pathology with quantification of the percentage of papillary serous component (% PSC ) and p53 expression .
This function requires not only the kinase domain of Csk , but also its Src homology 3 ( SH3 ) and SH2 regions .
Nucleotide sequence , transcription map , and mutation analysis of the 13q14 chromosomal region deleted in B - cell chronic lymphocytic leukemia .
In conclusion , primary chemotherapy based on high dose MTX and ara - C is highly efficient in PCNSL .
NGF , but not EGF , enhances the upper bands , corresponding to phosphorylated Fra - 2 .
METHODS AND RESULTS : Palmaz - Schatz stents were dip - coated with paclitaxel ( 0 , 0 . 2 , 15 , or 187 microgram / stent ) by immersion in ethanolic paclitaxel and evaporation of the solvent .
Currently , the clinical use of 5 - aminolaevulinic acid ( ALA ) induced protoporphyrin IX ( PPIX ) for photodynamic therapy ( PDT ) is limited by the maximum tolerated oral ALA dose ( 60 mg / kg ).
A twelfth insertion disrupts two genes , Nrk , a " neurospecific " receptor tyrosine kinase , and Tpp , which encodes a neuropeptidase .
These results indicate that ATF4 regulates basal and CdCl ( 2 )- induced expression of the ho - 1 gene in a cell - specific manner and possibly in a complex with Nrf2 .
Adjuvant and neoadjuvant treatment of breast cancer .
The % SVend of HCM - I was significantly lower than the respective values of the HCM - II and Control groups .
Inhibition of the Raf - 1 target ERK kinase ( MEK ) either attenuated or abolished Rp - cAMPS - and PKI - induced ERK activation , caldesmon phosphorylation , and stress fiber formation .
In the TVD - patients decreases in skin blood flow were similar compared with the healthy controls .
Analysis of mCTR mRNAs has revealed that the three alternative promoters give rise to at least seven mCTR isoforms in the 5 ' region of the gene and generate 5 '- untranslated regions of very different lengths .
The regulation of PGHS - 2 mRNA and protein was studied in primary cultures of bovine uterine stromal cells stimulated with phorbol 12 - myristate 13 - acetate ( PMA ; 100 nM ).
There was no evidence of linkage disequilibrium between the polymorphic site in the B cell specific promoter and those in the 3 ' UTR .
Several dozen HIF - 1 targets are known , including the gene encoding vascular endothelial growth factor ( VEGF ).
In Klinefelter ' s syndrome ( 47XXY ), serum testosterone levels are at the lower end of the normal range and dihydrotestosterone levels are low .
The protein is composed of two major domains separated by a hydrophobic linker region of 20 amino acid residues .
When mixed with aqueous solutions of TMT - 55 , aqueous solutions of either reagent - grade zinc , cadmium , or lead salts precipitate crystalline " Zn - TMT ", amorphous or crystalline " Cd - TMT " or amorphous " Pb - TMT " ( M3 [ S3C3N3 ] 2 . nH2O , where M = Cd2 +, Pb2 +, and Zn2 + and n > or = 0 ) that may eventually crystallize if stored in air .
Online teaching : design and techniques .
This interaction is reciprocal , since C / EBP dimer binding to a strong C / EBP site leads to enhanced CREB - 1 recruitment to ATF / CREB sites that are weakly bound by CREB .
The absorbed dose was measured by combination of two integrating detectors : thermo - luminescent dosemeter of Mg2SiO4 : Tb ( TDMS ) and plastic nuclear track detector ( PNTD ).
To determine the genomic complexity of the deleted region shared among tumors , we assembled a physical map of the I Mbp SRO consisting predominantly of bacteriophage P1 - derived artificial chromosome ( PAC ) clones .
Thus , Xlim - 1 not only contains a unique tyrosine - rich activation domain but also contains a negative regulatory domain in CT239 - 403 , suggesting a complex regulatory mechanism underlying the transcriptional activity of Xlim - 1 in the organizer .
Low - selenium diet has a human unfavourable impact .
In the next week , the beta - adrenergic antagonist atenolol was added at an initial dose of 25 mg / day and titrated to 50 mg / day within 1 week .
To assess more specific PKA - dependent mediation of LH ' s contribution to combined hormonal drive , the LDL receptor (- 1076 to + 11 bp ) reporter plasmid was cotransfected with a full - sequence rabbit muscle protein kinase inhibitor ( PKI ) minigene driven constitutively by a Rous sarcoma virus promoter .
In SN - 48 neuronal cells that express MR , GR , and 5 - HT1A receptors , deletion or inactivation of the nGRE ( negative GRE ) eliminated negative regulation of the rat 5 - HT1A or heterologous promoters by corticosteroids , whereas its inclusion conferred corticosteroid - induced inhibition to a heterologous promoter .
Transition between P - and H - BPPV was found in 6 cases .
These included HNF - 3 beta , HFH - 1 , HFH - 2 , HFH - 3 , C / EBP , and C / EBP beta , all of which are consistent with the tissue - specific expression profiles of the gene .
RESULTS : Of the 24 patients , 6 had Grade 1 pneumonitis , and 13 had Grade 2 pneumonitis .
METHODS : The passive and active transport of fluorescein through the BRB was quantitated by vitreous fluorometry .
Sixteen out of 52 seropositive MS patients ( 30 . 8 %) showed intrathecal synthesis of C . pneumoniae - specific IgG but only one of 43 seropositive controls ( 2 . 3 %).
Consistent with the specificity observed for the interaction of DmCKIIalpha with these bHLH proteins , sequence alignment suggests that only m5 , m7 , and m8 contain a consensus site for phosphorylation by CKII within a subdomain unique to these three proteins .
Deletion of the potential initiator element does not affect repression of the p21 promoter by c - Myc .
PATIENTS AND METHODS : Between June 1991 and December 1996 , we administered the nucleoside analog 2 - chlorodeoxyadenosine ( 2 - CDA ) to 73 children with primary AML and 20 children with secondary AML or myelodysplastic syndrome ( MDS ).
Drosophila Menin1 gene transcripts use alternative polyadenylation sites resulting in 4 . 3 and 5 - kb messages .
Mice homozygous for the dlg mutation exhibit growth retardation in utero , have hypoplasia of the premaxilla and mandible , have a cleft secondary palate , and die perinatally .
In contrast , we did not detect a significant correlation between plasma TNFalpha and radiation pneumonitis .
Its transcription in vitro by pol III requires the same factors as the U6 gene with the major exception that the modified TATA - box of this construct only interacts with a TATA - binding protein ( TBP ) mutant ( TBP - DR2 ) but not with TBP wild - type ( TBPwt ).
Expression of the src homology 3 ( SH3 )- encoding , expressed in tumorigenic astrocytes ( SETA ) gene is associated with astrocyte transformation in culture and tumors in the adult brain .
In such conditions , the following kinetic reactions have been studied : N2 ( A ) + N2 ( A ) --> N2 ( C , B , V ') + N2 ( X ), N2 ( A ) + N2 ( X , V > 5 ) --> N2 ( X ) + N2 ( B , V ') in pure N2 post - discharges and N2 ( A ) + CH4 --> products , C + N + M2 --> CN ( B , V ') + M2 , N2 ( X , V > 4 ) + CN --> N2 ( X ) + CN ( B , A , V '), in N2 - 1 % CH4 post - discharges .
BACKGROUND / AIMS : Hepatitis C and nonalcoholic fatty liver disease ( NAFL ) are the two most common forms of liver disease in the United States .
These results suggested a critical role for tyrosine residue 1229 in the regulation of L1 endocytosis .
The androgen receptor ( AR ) amino - terminus imposes androgen - specific regulation of AR gene expression via an exonic enhancer .
Can survival be prolonged for patients with hormone - resistant prostate cancer ?
In conclusion , NF - Y and Sp1 binding sites play a decisive role in the basal expression of the rat mrp2 gene , while the human MRP2 gene is regulated differently .
Intact Flag - tagged protein products from all six were produced from genomic expression vectors , although the ORF40 / 41 transcript encoding a primase - helicase component proved to be spliced with a 127 - bp intron .
Hypomorphic dSLBP alleles support zygotic development but cause female sterility .
In hypertensive nephrosclerosis , therapy containing an ACEI alone or in combination significantly reduces the incidence of renal events .
We confirmed the interaction between TLS and p65 by the pull - down assay in vitro and by a coimmunoprecipitation experiment followed by Western blot of the cultured cell in vivo .
In addition , we did not detect significant differences in CDR3 sequences of endogenous Ig lambdaL and kappaL chain gene loci cloned from peripheral blood lymphocytes of an NBS patient and of healthy individuals .
The diet of migrants showed both positive ( macronutrients ) and negative ( micronutrients ) differences with the general Dutch diet .
Copyright 2001 Academic Press .
Experimental study of ta chengchi tang decoction for relieving lung injury during acute necrotizing pancreatitis ] The objectives of the study were to investigate the changes of leukocyte adhesiveness and tumor necrosis factor ( TNF ) in the early stage of acute necrotizing pancreatitis ( ANP ), to go further into the relation of those changes to lung injury of ANP , and to evaluate the prohibitive effect of ta chengchi tang Decoction on leukocyte adhesion and TNF secretion .
We suggest that ventriculopleural shunting should be considered as the preferred alternative to peritoneal drainage in children with intra - abdominal adhesions or with a history of recent peritoneal infection .
Positive and significant correlations were found between the weeks of pregnancy and Se levels in kidney ( r = 0 . 433 , P = 0 . 023 ) and heart ( r = 0 . 313 , P = 0 . 030 ).
Doxorubicin ( DOX ) is commonly used for the treatment of hematological and solid tumors .
There was no significant difference in developmental scores at 9 or 18 months , although PDF infants had a 2 . 8 (- 1 . 3 - 6 . 8 ) point advantage in Bayley motor score scales .
Immunofixation experiments of C4A and C4B demonstrate > 41 allotypes in the two classes of proteins .
These effects were not seen with SHIP2 possessing a mutation in the SH2 domain ( R47G ).
Myasthenia gravis is an autoimmune disease resulting from the production of antibodies against the ACh receptors of the neuromuscular synapse .
Human homologue of yeast Rad23 protein A interacts with p300 / cyclic AMP - responsive element binding ( CREB )- binding protein to down - regulate transcriptional activity of p53 .
METHODS : Sixteen pigs were assigned randomly to control and shock groups .
RESULTS : There is a considerable amount of variation between the results of TRA1 and TRA2 and between the results of both TRA ' s and the door - to - door survey .
Thus , our studies define Rac / Cdc42 / Pak as a module upstream of Raf - 1 during its activation by microtubule disruption .
Zhu , V .
However , plasmids carrying the yeast TyrRS gene could not be stably maintained in E . coli .
This supports previous arguments for the improbability of biological effects at UHF frequencies unless a mechanism can be found for accumulating energy over time and space and focussing it .
The students who had abnormal urine screening results at the first time received a second urine analysis 10 to 15 days later to confirm the abnormal urine analysis .
Cells containing alpha subunits that lacked a distal domain ( term - 3 ) or had the alternatively spliced alpha - 2 distal domain showed markedly decreased ability to support tyrosine phosphorylation of Jak - 2 and its substrates or to up - regulate CD86 .
Despite abundant expression of NtmybAS transcripts in mature pollen , gPAL1 transcripts were not detectable in pollen .
Finally , profiling of a gcn4Delta mutant uncovered an alternative induction pathway operating at many Gcn4p target genes in histidine - starved cells .
The R2 between MFI of fresh and frozen muscle was 0 . 94 and 0 . 92 for lamb and pork longissimus , respectively .
To this end , an expression cassette consisting of the gene for a green fluorescent protein ( GFP ) flanked at its 3 ' end by EAV - specific transcription - regulating sequences was constructed .
Significantly higher lung function parameters were obtained in extubated recipients of LPD preserved grafts 2 weeks after TX .
Lack of association between Kawasaki syndrome and infection with Rickettsia conorii , Rickettsia typhi , Coxiella burnetii or Ehrlichia phagocytophila group .
These utilisation data imply annual drug costs in the range of $ US 480 , 000 to $ US 3 , 600 , 000 for TNF antagonists for RA per 1 million population .
Alignment of different cDNAs of the NR5A2 ( hB1F ) gene with the genomic sequence facilitated the delineation of its structural organization , which spans over 150 kb and consists of eight exons interrupted by seven introns .
CONCLUSIONS : Ketamine - induced dissociative anesthesia produces persistently elevated BIS index which is different from thiamylal and those reported with other conventional anesthetic agents .
In the remaining case , the aneurysm originated from the proximal end of the associated A1 fenestration .
This domain without the canonical anticodon loop or the tyrosine anticodon acts as an anchor for TyrRS interaction leading to a better efficiency of tyrosylation .
Temperature measurement in microfluidic systems using a temperature - dependent fluorescent dye .
The first exon ( exon 1A ) that corresponded to the 5 '- untranslated region of the GHR 1A mRNA was 15 , 250 bp upstream from exon 2 in the GHR gene .
The NAUSICAA system gives a good knowledge of LET spectra for the first time in space dosimetry .
The MABP and MCBFV signals were bandpass filtered in the very low - frequency range ( VLF , 0 . 015 - 0 . 07 Hz ), low - frequency range ( LF , 0 . 07 - 0 . 15 Hz ) and high - frequency range ( HF , 0 . 15 - 0 . 40 Hz ) before applying CCF for the purpose of studying the effect of different bandwidths on the resulting mean CCFs .
At cross purposes .
For these patients the introduction of a separate category " extended oligoarthritis at onset " should be considered to establish comparable patient groups .
The susceptibility of Aspergillus fumigatus to mulundocandin , an echinocandin - like compound , and other antifungal agents was assessed by the National Committee for Clinical Laboratory Standards ( NCCLS ) M38 - P method , a 2 , 3 - bis ( 2 - methoxy - 4 - nitro - 5 - sulfophenyl )- 5 -[( phenyl - amino ) carbonyl ]- 2H - tetrazolium hydroxide ( XTT )- based colorimetric assay , and determination of morphologic alterations by microscopy .
The most important risk factors are : 1 ) genetic ; 2 ) Epstein - Barr virus ( infectious mononucleosis ); 3 ) congenital and acquired immunodeficiency ; 4 ) occupational exposure ( the wood industry ).
Members of the AP - 1 superfamily of basic - leucine zipper factors bind to the StRE .
DNA recognition by F factor TraI36 : highly sequence - specific binding of single - stranded DNA .
Overexpression of RORgamma has been shown to inhibit T cell receptor - mediated apoptosis in T cell hybridomas and to repress the induction of Fas - ligand and interleukin 2 .
Although metabolized by the cytochrome P - 450 ( CYP ) system , venlafaxine inhibits CYP 2D6 and 3A4 to a far lesser extent than do the SSRIs .
SAPK / JNK activation was completely abolished in the absence of MKK7 , even though expression of MKK4 was strongly upregulated in mkk7 (-/-) mast cell lines , and phosphorylation of MKK4 occurred normally in response to multiple stress stimuli .
However these search engines respond with such cumbersome results that domain specific experts can not tolerate .
The titer of TSH binding inhibitor immunoglobulin ( TBII ), which had been 8 . 6 % at initial presentation , rose to 14 . 9 % in 2 weeks .
The extraordinary stability of peptide -- gp96 complexes and the plasticity of the peptide - binding pocket support the proposed relay of diverse peptides to MHC and / or other molecules via molecular recognition .
Elevated expression of full - length UhpB or of a soluble hybrid protein , GST - Bc , which is glutathione S - transferase ( GST ) fused to the cytoplasmic C - terminal portion of UhpB , results in complete blockage of uhpT expression in a uhp (+) strain .
Physical principles in therapeutic apheresis .
Evidence from a Northern hybridization indicated that jadM expression is correlated with jadomycin B synthesis .
Multiple copies of rsmB + DNA , on the other hand , stimulate exoenzyme production by relieving the negative effects of a chromosomal copy of hexA +.
Systematic review of diagnostic tests for vaginal trichomoniasis .
Anecdotal observations scattered throughout the literature have often provided clues to underlying variations in humans ' ability to handle dietary chemicals .
Here we show that phosphorylation - induced loss of the protein kinase activity of DNA - PK is restored by the addition of the purified catalytic subunit of either protein phosphatase 1 or protein phosphatase 2A ( PP2A ) and that this reactivation is blocked by the potent protein phosphatase inhibitor , microcystin .
Herein PPARgamma , liganded by either natural ( 15d - PGJ ( 2 ) and PGD ( 2 )) or synthetic ligands ( BRL49653 and troglitazone ), selectively inhibited expression of the cyclin D1 gene .
An integrated RTC algorithm for the urban wastewater system is formulated , the parameters of which are optimized using various global optimization routines .
Recently , we discovered that alanine substitutions of the active center cleft residues significantly impair the depurinating and ribosome inhibitory activity of PAP .
This partial transection could permit vasopressin to be secreted in response to a larger rise in plasma sodium concentration .
Reciprocally , HMGI - C expression also coordinately enhances PIAS3 - mediated repression of STAT3 - dependent transactivation .
The genomic structure of the human SPEC1 gene reveals complex splicing and close promoter proximity to the AF1q translocation gene .
Here , the PEX5 - TPR domains from human , tobacco , and nematode were inserted into a TPR - less yeast Pex5p construct to generate Pex5p chimaeras .
This study demonstrates that inducible expression in response to either PMA or TPO is mediated through the Ets site in the proximal promoter of GPIX and is dependent upon the upstream activation of MAPK / extracellular signal - regulated kinase .
Molecular identification of smg - 4 , required for mRNA surveillance in C . elegans .
Cytosolic acetyl - CoA synthetase ( AceCS1 ) activates acetate to supply the cells with acetyl - CoA for lipid synthesis .
There was an increase in protein binding onto this element only after peptide treatment .
While these results are consistent with previously reported effects of the C - terminal domain on nucleotide binding , they also demonstrate that interactions with the N - terminal domains are necessary to inhibit proton transport .
These findings suggest that an intracellular WT - 1 / HSAL2 pathway may play a role in development and hematopoiesis .
The radial forearm flap is used most commonly , however the lateral arm flap may be the flap of choice in certain situations .
The procedure is less aggressive and painful than sternotomy .
In addition , we have isolated a genomic fragment containing the most distal 5 ' sequences of the major GGT mRNA in HepG2 cells .
Further , the osteo - retentive ability of the hydroxyapatite in the sockets was seen to be close to significance ( after six months width differences , in the canine region : P = 0 . 059 , LHS , and P = 0 . 065 , RHS ).
These findings suggest a novel ankyrin - independent role for LAD - 1 related to FGFR signaling .
Managing vertigo and vertigo syndromes in the elderly
A single base change ( A8G ) in either sequence reduces hnRNP A2 binding and , in the case of A2RE - 2 , inhibits RNA transport .
A method of three - station three - dimensional magnetic resonance ( MR ) angiography of the lower extremities with segmented volume acquisition is presented .
Treatment of N18TG - 2 cells with a demethylating agent , 5 - aza - deoxycytidine , resulted in an expression of mlt 1 , indicating that the repression of mlt 1 is attributable to methylation Thus , mlt 1 is a novel target gene that is silenced by methylation during liver tumorigenesis initiated by SV40 T antigen .
We found in the control subjects rCBF increases in regions associated with the meso - striatal and meso - corticolimbic circuits in response to both monetary reward and nonmonetary reinforcement .
Reverse transcriptase - polymerase chain reaction assays showed that PKRDeltaE7 is expressed in a broad range of human tissues at variable levels .
For this purpose , the immediate and the final ( after swelling ) fixation strengths of two variations of the swellable bone anchor designs ( a smooth anchor and a screw anchor ) were measured in two different foams ( used to simulate bone ) with different densities .
CYP2C19 genotype was determined by the polymerase chain reaction - restriction fragment length polymorphism method .
It is useful as an adjunct to mammography in those patients with radiographically dense breasts for the characterization of palpable masses .
Activation of transcription through the AP - 1 site in Jurkat cells by JunD and / or Fra - 2 was weak . c - Jun , JunB , and c - Fos activation was greater , although the level was still less than that with Tax .
Thus , the screen for toxic p53 mutants in yeast can identify novel p53 variants that may be useful in dissecting p53 regulated cellular responses and in developing p53 - based cancer therapies .
Local control rates were 91 % for metastatic lung cancer , 89 % for primary lung cancer and 85 % for T1 , 2N0M0 cases .
The results show that cognitive stimulation enhanced performance on the Boston Naming Test and a Word List Recognition Task ; physical intervention , however , did not reach statistical significance .
Gimpl , F .
The actA gene is present as a single copy in the genome of A . chrysogenum ; and its expression level , opposite to pcbC and cefEF cephalosporin biosynthetic genes , was steady during cephalosporin fermentation , showing a single 1 . 4 - kb transcript .
Maternal p , p ' DDE and beta - HCH levels were also associated with newborn levels , but levels of PCBs were not .
The patients and their families were closely questioned , and full clinical examination included a test for orthostasia .
The expression of alpha - amylase can be transactivated by the transcription factor GAMyb , which is itself induced by GA .
Cardiac output at anaerobic threshold ( COAT ) < or = 7 . 3 L / min was the best cutoff value for identifying multivessel coronary artery disease ( relative risk , 3 . 1 ).
Tolerance to ADAL - 2 was similar to that of Vicryl suture and tolerance to ADAL - 2 was superior to that to Tisuacryl .
In the base - case analysis , total direct costs per patient were $ 728 for zoledronic acid and $ 776 for pamidronate .
METHODS : We retrospectively selected 13 TFCD patients who underwent surgery for intractable epilepsy with the aim of removing the magnetic resonance ( MR )- detectable lesion and / or the epileptogenic zone defined by stereoelectroencephalographic recordings .
To gain an understanding of the mGSTM2 regulation , we have also cloned and analyzed its promoter region .
Cyclins are one of the pivotal determinants regulating cell cycle progression .
Architecture and anatomy of the genomic locus encoding the human leukemia - associated transcription factor RUNX1 / AML1 .
Three of the proteins involved in checkpoint signaling , Rad1 , Hus1 , and Rad9 , have been shown to interact by immunoprecipitation and yeast two - hybrid studies .
Together these data imply that the HFV R region acts in the nucleus to modify the cytoplasmic fate of target HFV mRNA .
However , patients with isolated office hypertension had fewer previous cardiovascular complications .
Through deletion mutagenesis , we identify amino acids 2003 to 2212 of CBP , which we call carboxy - terminal region 2 ( CR2 ), as the minimal region for Tax interaction .
Fetal lung volume : estimation at MR imaging - initial results .
Plane wave geometry is impractical for clinical use but the results of this work encouraged us to further develop the P3 approximation for a spherical geometry , described in this paper .
For the sample of systematic reviews drawn from ACP Journal Club ( n = 103 ), the PubMed strategy achieved a sensitivity of 97 % ( CI , 91 % to 99 %).
In addition to that , she received hepatic intra - arterial infusion of levoforinate ( l - LV ) 250 mg and 5 - fluorouracil ( 5 - FU ) 500 mg for combined multiple hepatic metastases starting on postoperative day 14 , and these medications were administered over 48 hours once weekly by infuser pump .
Because of differences in patient characteristics , control measurements were obtained from normal muscle in all patients .
Two families with concordant inheritance of DNAH9 alleles in affected individuals were observed .
NIRS was used for the quantitative measurement of muscle O ( 2 ) consumption ( mV . O ( 2 )) and forearm blood flow ( FBF ) in 78 healthy subjects .
Many factors do influence the educational outcome in students and large statistical power ( such as meta analysis ) should be helpful to eliminate many sources of error .
B - myb is essential for G1 / S transition and has been shown to be phosphorylated by the cyclin A2 / cdk2 complex .
Like the consensus mammalian LHbeta gene , the 5 '- flanking region of the gpLH / CGbeta gene contains a single TATA sequence 37 bp upstream of the translation start codon .
HTLV - 1 decreases Th2 type of immune response in patients with strongyloidiasis .
Indeed , mutation of two of these motifs , known to be important to regulation of sid1 , altered the differential regulation of sid2 by iron .
Nutritional status in adults on an alternative or traditional diet ] BACKGROUND : Plant food lacks vitamin B12 , vitamin D and higher n - 3 polyunsaturated fatty acids .
On the other hand , forced overexpression of the wild type , but not the kinase - inactivated mutant of nm23H1 , converted the GDP - bound forms of Rac1 , Cdc42 , and RhoA to their GTP - bound forms in vitro by its nucleoside diphosphate kinase activity , but nm23H1 alone apparently did not produce the GTP - bound form of these GTPases in vivo .
Novel intronic promoter in the rat ER alpha gene responsible for the transient transcription of a variant receptor .
RESULTS : Coronary mortality during the median follow - up time of 17 months was 6 - fold higher in the highest tertile for CRP and IL - 6 and 3 . 5 - fold higher in the highest tertile for fibrinogen and TNF - alpha than in the respective combined lower tertiles .
HIV - 1 and hepatitis B virus infections in adolescents lodged in security institutes of Buenos Aires .
However , the promoter region contains several potential cis - regulatory elements such as Sp1 , early growth response - 1 , activator protein - 2 , MyoD , p300 , nuclear factor - kappaB , myeloid zinc finger protein - 1 , caudal - related homeobox ( Cdx ) gene A , and Cdx protein - 2 binding sites .
RPM / RGL3 resembled AF - 6 and Nore1 in interacting strongly with constitutively active M - Ras and p21 Ras .
METHODS : 93 female and 43 male patients undergoing thyroid surgery were stratified according to gender and then randomised to receive double - blind one of four antiemetic regimes : 50 mg dolasetron given orally 45 minutes prior to induction of anaesthesia ( group I ), 12 . 5 mg dolasetron given intravenously during induction of anaesthesia ( group II ), 1 . 25 mg DHB given intravenously during induction of anaesthesia ( group III ) or placebo ( group IV ).
Transcriptional regulation of the estrogen - inducible pS2 breast cancer marker gene by the ERR family of orphan nuclear receptors .
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Comparison/O with/O alkaline/I phosphatases/I and/O 5/I -/I nucleotidase/I
Pharmacologic/O aspects/O of/O neonatal/O hyperbilirubinemia/O ./O
When/O CSF/O [/O HCO3/O -]/O is/O shown/O as/O a/O function/O of/O CSF/O PCO2/O the/O data/O of/O K/O -/O depleted/O rats/O are/O no/O longer/O displaced/O when/O compared/O to/O controls/O but/O still/O have/O a/O significantly/O greater/O slope/O (/O 1/O ./O 21/O +/-/O 0/O ./O 23/O vs/O ./O
Flurazepam/O thus/O appears/O to/O be/O an/O effective/O hypnotic/O drug/O with/O the/O optimum/O dose/O for/O use/O in/O general/O practice/O being/O 15/O mg/O at/O night/O ./O
Beta/O blocking/O agents/O ./O
When/O extracorporeal/O CO2/O removal/O approximated/O CO2/O production/O (/O VCO2/O ),/O alveolar/O ventilation/O almost/O ceased/O ./O
Intravenous/O administration/O (/O 25/O mg/O //O kg/O )/O of/O carbonic/I anhydrase/I inhibitors/O (/O acetazolamide/O ,/O methazolamide/O ,/O dichlorphenamide/O ,/O sulthiame/O )/O induced/O an/O early/O important/O rise/O of/O cortical/O p/O O2/O ,/O which/O is/O not/O dependent/O on/O increase/O of/O p/O O2/O and/O p/O CO2/O and/O decrease/O of/O pH/O in/O arterial/O blood/O ./O
Teratological/O study/O of/O etoperidone/O in/O the/O rat/O and/O rabbit/O ./O
Colorectal/O polyps/O should/O be/O removed/O endoscopically/O whenever/O possible/O ./O
The/O variable/O HMG/I dosage/O regimen/O was/O found/O to/O offer/O no/O advantages/O when/O compared/O with/O our/O standard/O daily/O dosage/O regimen/O ./O
When/O the/O CO2/O content/O reached/O 9/O Vol/O %/O the/O animals/O became/O apathic/O and/O lost/O body/O weight/O ./O
Serum/I gamma/I glutamyltransferase/I in/O the/O diagnosis/O of/O liver/O disease/O in/O cattle/O ./O
By/O contrast/O ,/O secretory/I HI/I antibodies/I were/O not/O demonstrated/O at/O the/O onset/O of/O illness/O in/O any/O of/O the/O patients/O ,/O but/O their/O formation/O started/O early/O and/O the/O antibodies/O reached/O maximal/O levels/O about/O 10/O days/O after/O onset/O of/O illness/O ./O
With/O the/O exception/O of/O virus/O assay/O and/O quantitation/O ,/O these/O methods/O are/O simple/O and/O inexpensive/O enough/O to/O be/O done/O in/O typical/O shellfish/O microbiology/O laboratories/O ./O
Characteristics/O of/O lipase/I activity/O ./O
Takayasu/O '/O s/O disease/O :/O association/O with/O HLA/I -/I B5/I ./O
SGPT/I ,/O SGOT/I ,/O and/O alkaline/I phosphatase/I concentrations/O were/O essentially/O normal/O in/O all/O subjects/O ./O
Gamma/I glutamyl/I transpeptidase/I (/O GGTP/I )/O activity/O in/O the/O seminal/O fluid/O
Patients/O with/O Parkinson/O '/O s/O disease/O showed/O a/O relatively/O high/O incidence/O to/O psychoses/O during/O drug/O treatment/O (/O 51/O ./O 47/O %)./O
Selective/O stimulation/O of/O central/O alpha/I -/I autoreceptors/I following/O treatment/O with/O alpha/O -/O methyldopa/O and/O FLA/O 136/O ./O
Anti/O -/O anxiety/O action/O of/O diazepam/O after/O intra/O -/O amygdaloid/O application/O in/O the/O rat/O ./O
Abstracts/O ./O
Removal/O of/O thick/O ,/O permanently/O altered/O mucoas/O is/O recommended/O even/O in/O the/O absence/O of/O squamous/O epithelium/O ./O
An/O IgG/I monoclonal/O gammopathy/O was/O present/O in/O the/O serum/O of/O 4/O patients/O and/O Bence/O -/O Joanes/O proteinuria/O was/O found/O in/O 1/O patient/O ./O
Studies/O on/O immunoglobulin/I E/I :/O the/O impact/O of/O a/O sojourn/O with/O Professor/O Dan/O H/O ./O
Peroxydase/I reaction/O stains/O were/O negative/O ,/O chloroacetate/I esterase/I were/O strongly/O positive/O ./O
Ten/O out/O -/O patients/O with/O pustulosis/O palmaris/O et/O plantaris/O were/O examined/O with/O direct/O immunofluorescence/O (/O IF/O )/O technique/O for/O deposition/O of/O fibrinogen/I ,/O fibrin/I or/O its/O degradation/O products/O (/O FR/I -/I antigen/I )/O in/O affected/O and/O unaffected/O skin/O ,/O together/O with/O heparin/O -/O precipitable/O fraction/O (/O HPF/O ),/O cryoglobulin/I and/O total/O plasma/O fibrinogen/I in/O the/O blood/O ./O
Of/O 600/O mediastinoscopies/O carried/O out/O from/O 1966/O to/O 1973/O ,/O 479/O were/O performed/O to/O assess/O the/O operability/O of/O a/O pulmonary/O carcinoma/O ./O
A/O mixture/O of/O human/I albumin/I 5/O %/O and/O hydroxy/O -/O ethyl/O -/O starch/O was/O used/O as/O a/O solution/O for/O dilution/O ./O
In/O the/O matched/O control/O group/O the/O acquisition/O -/O rate/O of/O both/O symptomatic/O and/O asymptomatic/O 0acteriuria/O was/O over/O 12/O %,/O a/O figure/O similar/O to/O the/O percentage/O of/O women/O present/O in/O the/O practice/O population/O during/O one/O year/O with/O transient/O ,/O symptomatic/O ,/O and/O persistent/O A/O ./O B/O ./O
Late/O complications/O of/O catheterisation/O for/O intravenous/O nutrition/O ./O
Prenatal/O diagnosis/O of/O galactosaemia/O ./O
Sings/O which/O are/O indicative/O of/O metaplastic/O erythropoiesis/O are/O absent/O ./O
False/O positive/O amniotic/I fluid/I alpha/I fetoprotein/I levels/O resulting/O from/O contamination/O with/O fetal/O blood/O :/O results/O of/O an/O experiment/O ./O
Serum/O -/O ferritin/I in/O diagnosis/O of/O haemochromatosis/O ./O
In/O 2/O subjects/O the/O phytomitogen/O reactivity/O of/O the/O lymphocytes/O was/O improved/O after/O treatment/O ./O
Patients/O at/O risk/O of/O hypothyroidism/O ./O
Albumin/I and/O cyclic/O AMP/O levels/O in/O peritoneal/O fluids/O in/O the/O child/O
Preface/O ./O
Thirty/O -/O five/O strains/O of/O Legionnaires/O '/O disease/O bacteria/O were/O shown/O to/O belong/O in/O four/O distinct/O serologic/O groups/O on/O the/O basis/O of/O findings/O obtained/O with/O direct/O fluorescent/O antibody/O testing/O ./O
On/O the/O other/O hand/O factor/I IX/I activity/O is/O decreased/O in/O coumarin/O treatment/O with/O factor/I IX/I antigen/O remaining/O normal/O ./O
The/O concentration/O of/O alpha/I 2/I -/I macroglobulin/I ,/O alpha/I 1/I -/I antitrypsin/I ,/O plasminogen/I ,/O C3/I -/I complement/I ,/O fibrinogen/I degradation/I products/I (/O FDP/I )/O and/O fibrinolytic/O activity/O ,/O were/O studied/O in/O the/O aqueous/O humour/O and/O serum/O from/O nine/O patients/O with/O Fuchs/O '/O endothelial/O dystrophy/O ,/O 17/O patients/O with/O uncomplicated/O senile/O cataract/O and/O in/O the/O secondary/O aqueous/O from/O six/O cataract/O patients/O ./O
Only/O 17/O %/O of/O all/O patients/O admitted/O it/O at/O all/O times/O ./O
Prazosin/O alone/O was/O effective/O in/O volume/O responsive/O patients/O at/O a/O dose/O of/O 5/O +/-/O 1/O ./O 0/O mg/O daily/O ./O
T4/O and/O FT4I/O followed/O parallel/O courses/O in/O both/O groups/O ;/O during/O the/O first/O 45/O days/O ,/O however/O ,/O the/O values/O were/O significantly/O lower/O in/O premature/O infants/O under/O 34/O weeks/O '/O EGA/O than/O in/O term/O infants/O (/O P/O less/O than/O 0/O ./O 001/O )./O
A/O three/O -/O phased/O analysis/O of/O treatment/O plans/O for/O 45/O patients/O was/O undertaken/O ./O
Aspirin/O intolerance/O :/O unaltered/O susceptibility/O of/O platelet/I cyclo/I -/I oxygenase/I to/O inhibition/O by/O aspirin/O in/O vitro/O ./O
These/O results/O indicate/O that/O cynomolgus/O monkeys/O are/O either/O less/O sensitive/O or/O respond/O differently/O than/O rhesus/O monkeys/O to/O some/O of/O the/O pharmacological/O effects/O of/O norcocaine/O ./O
59/O cases/O of/O surgically/O resectable/O cancers/O (/O T1/O ,/O T2/O ,/O T3/O ,/O N0/O ,/O N1/O )/O had/O a/O minimum/O followup/O of/O two/O years/O (/O average/O 4/O years/O +/-/O 3/O months/O )./O
The/O effect/O of/O CBZ/O and/O DPH/O can/O be/O explained/O by/O interference/O with/O thyroid/O hormone/O binding/O to/O TBG/I combined/O with/O enzyme/O -/O induced/O increased/O metabolic/O clearance/O rate/O of/O thyroid/O hormones/O without/O homeostatic/O maintenance/O of/O premedication/O levels/O of/O FT4/O and/O FT3/O ./O
The/O present/O research/O evaluated/O the/O possibility/O that/O polyethylene/O glycol/O 400/O (/O PEG/O 400/O )/O might/O be/O efficacious/O ,/O toxic/O ,/O or/O both/O ./O
According/O to/O their/O functional/O properties/O the/O latter/O neurons/O were/O subdivided/O into/O :/O (/O a/O )/O neurons/O responding/O to/O stimuli/O near/O the/O eyes/O ;/O (/O b/O )/O neurons/O triggered/O by/O complex/O visual/O stimuli/O ;/O (/O c/O )/O neurons/O inhibited/O by/O visual/O stimuli/O ./O
Pentobarbital/O (/O 1/O ,/O 3/O ,/O 10/O ,/O and/O 17/O ./O 5/O mg/O //O kg/O )/O was/O also/O tested/O in/O combination/O with/O rate/O -/O decreasing/O doses/O of/O normeperidine/O (/O 17/O ./O 5/O mg/O //O kg/O ),/O anileridine/O (/O 10/O mg/O //O kg/O ),/O alphaprodine/O (/O 10/O mg/O //O kg/O ),/O and/O fentanyl/O (/O 0/O ./O 3/O mg/O //O kg/O )./O
Pb/O foil/O (/O 0/O ./O 55/O gcm/O -/O 2/O )/O provided/O the/O best/O overall/O improvement/O ./O
An/O anatomical/O and/O histochemical/O study/O has/O been/O undertaken/O and/O as/O a/O result/O emphasis/O is/O given/O to/O recent/O hypotheses/O that/O suggest/O there/O are/O similarities/O with/O Type/O IV/O glycogen/O storage/O disease/O (/O Andersen/O '/O s/O disease/O )/O which/O ,/O although/O clinically/O distinct/O ,/O has/O the/O same/O enzyme/O defect/O ./O
All/O groups/O were/O tested/O in/O a/O Hebb/O -/O Williams/O maze/O at/O 100/O approximately/O 10/O days/O of/O age/O ./O
Erythromycin/O and/O clindamycin/O resistance/O in/O Corynebacterium/O diphtheriae/O from/O skin/O lesions/O ./O
Imposed/O angular/O displacements/O of/O monkey/O '/O s/O wrist/O produce/O three/O major/O peaks/O of/O activity/O (/O terms/O M1/O ,/O M2/O ,/O and/O M3/O peaks/O )/O in/O the/O averaged/O gross/O EMG/O activity/O ot/O the/O stretched/O muscles/O ./O
Hemolytic/O disease/O of/O African/O newborn/O ./O
In/O this/O animal/O ,/O infected/O with/O what/O was/O judged/O previously/O to/O be/O the/O less/O virulent/O of/O the/O two/O T/O ./O cruzi/O stocks/O used/O ('/O strain/O 7/O '),/O there/O was/O severe/O myocarditis/O ,/O with/O myofibre/O degeneration/O ,/O and/O lesions/O of/O the/O oesophagus/O ./O
The/O majority/O of/O MRF/O units/O were/O behaviorally/O incongruent/O ;/O in/O the/O most/O frequently/O observed/O case/O ,/O their/O activity/O failed/O to/O change/O reliably/O when/O behavior/O habituated/O ./O
Variability/O within/O Down/O '/O s/O syndrome/O (/O trisomy/O -/O 21/O ):/O empirically/O observed/O sex/O differences/O in/O IQs/O ./O
VII/O ./O
Several/O demographic/O indices/O of/O isolated/O populations/O in/O Uzbekistan/O
2/O .--/O concepts/O of/O higher/O nervous/O function/O in/O the/O USSR/O ./O
The/O maintenance/O of/O increased/O myocardial/O capillary/O density/O required/O a/O similar/O amount/O of/O exercise/O ,/O and/O at/O least/O 1/O h/O of/O exercise/O once/O a/O week/O was/O necessary/O to/O maintain/O the/O enlargement/O of/O ECA/O ./O 20/O
These/O observations/O have/O led/O us/O to/O conclude/O that/O an/O elevated/O VIII/O -/O ratio/O is/O a/O very/O sensitive/O indicator/O of/O intravascular/O coagulation/O ./O
Eight/O hours/O after/O the/O administration/O of/O colchicine/O ,/O the/O serum/I ceruloplasmin/I level/O began/O to/O rise/O again/O in/O female/O rats/O ,/O but/O not/O in/O male/O rats/O ./O
Radioimmunoassays/O of/O pregnenolone/O ,/O progesterone/O ,/O dehydroepiandrosterone/O (/O DHA/O )/O 16/O alpha/O -/O hydroxy/O -/O DHA/O ,/O estriol/O ,/O and/O cortisol/O were/O performed/O on/O a/O total/O of/O 0/O ;/O 1/O ml/O ;/O of/O fetal/O plasma/O ,/O collected/O during/O the/O course/O of/O normal/O vaginal/O delivery/O ./O
In/O only/O two/O patients/O were/O we/O able/O to/O demonstrate/O changes/O suggestive/O of/O pulmonary/O metastases/O any/O earlier/O with/O a/O 99mTc/O -/O EHDP/O scan/O than/O with/O chest/O radiographs/O and/O one/O of/O these/O resolved/O spontaneously/O ./O
The/O majority/O of/O tumors/O occurred/O in/O the/O nasal/O cavities/O ,/O although/O significant/O incidences/O were/O also/O found/O in/O the/O larynx/O ,/O trachea/O and/O stem/O bronchi/O ./O
Prediction/O of/O the/O times/O of/O sandfly/O development/O
Native/O human/I fibrinogen/I was/O brought/O to/O coagulation/O by/O adding/O thrombin/I ./O
No/O post/O -/O operative/O haemorrhages/O from/O the/O prostheses/O were/O observed/O ./O
The/O Southern/O technique/O allowed/O a/O further/O localization/O of/O the/O region/O of/O most/O extensive/O transcription/O to/O a/O 1/O ./O 8/O kb/O HindIII/I -/O EcoRI/I fragment/O ./O
Accepting/O arbitrarily/O chosen/O limits/O of/O maximized/O errors/O of/O +/-/O 10/O %,/O it/O could/O be/O shown/O that/O the/O system/O did/O not/O work/O acceptably/O when/O the/O mean/O carbon/O dioxide/O concentration/O was/O below/O 1/O ./O 5/O vol/O .%/O within/O the/O fresh/O gas/O flow/O rates/O (/O 2/O ./O 2/O --/O 7/O ./O 7/O 1/O min/O -/O 1/O )/O and/O the/O range/O of/O minute/O ventilation/O (/O 4/O --/O 10/O 1/O min/O -/O 1/O )/O employed/O ./O
SV/O increased/O less/O in/O SHR/O ,/O mainly/O reflecting/O the/O reduced/O diastolic/O compliance/O of/O the/O hypertrophied/O SHR/O left/O ventricle/O and/O the/O consequent/O rightward/O shift/O of/O its/O Frank/O -/O Starling/O curve/O ./O
The/O carcass/O of/O a/O great/O horned/O owl/O (/O Bubo/O virginianus/O ),/O which/O had/O been/O found/O moribund/O in/O southern/O Ontario/O ,/O was/O presented/O for/O necropsy/O ./O
The/O inner/O ears/O were/O exposed/O by/O microdissection/O ,/O and/O the/O vestibular/O sensory/O regions/O were/O either/O sectioned/O and/O studied/O with/O light/O or/O electron/O microscopy/O ,/O or/O prepared/O and/O studied/O with/O the/O surface/O specimen/O technique/O ./O
Patulin/O is/O extracted/O from/O apple/O butter/O samples/O with/O ethyl/O acetate/O and/O the/O extract/O is/O cleaned/O up/O on/O a/O silica/O gel/O column/O ,/O using/O benzene/O -/O ethyl/O acetate/O (/O 75/O +/O 25/O )/O as/O the/O eluant/O ./O
Steroid/O glucuronides/O in/O amniotic/O fluid/O at/O term/O ./O
The/O matrix/O surrounding/O the/O clusters/O either/O showed/O a/O normal/O morphology/O or/O a/O homogeneous/O appearance/O ,/O within/O which/O faint/O cross/O striations/O but/O no/O distinctly/O fibrillar/O outlines/O could/O be/O identified/O ./O
Riboflavin/O did/O not/O affect/O the/O percentage/O of/O aflatoxin/O -/O treated/O animals/O with/O abnormal/O urinary/O excretion/O patterns/O ,/O but/O did/O increase/O the/O magnitude/O of/O the/O disturbances/O in/O elimination/O of/O kynurenic/O and/O xanthurenic/O acids/O ./O
Polyglactin/O 910/O suture/O absorption/O and/O the/O role/O of/O cellular/O enzymes/O ./O
The/O incidence/O of/O DNCB/O reactions/O was/O 78/O per/O cent/O for/O Stage/O I/O and/O II/O cancers/O (/O 37/O patinets/O ),/O 73/O per/O cent/O for/O resectable/O Stage/O III/O cancer/O (/O 22/O patients/O ),/O and/O 66/O per/O cent/O in/O patients/O with/O unresectable/O or/O inoperable/O Stage/O III/O cancer/O ./O
Studies/O of/O lipoproteins/O should/O ,/O however/O ,/O be/O made/O in/O children/O from/O families/O known/O to/O have/O FH/O or/O early/O coronary/O heart/O disease/O ./O
Sixteen/O other/O normal/O subjects/O with/O 2/O g/O of/O Metyrapone/O are/O best/O responses/O ./O
EEG/O theta/O waves/O and/O psychological/O phenomena/O :/O a/O review/O and/O analysis/O ./O
REM/O dream/O content/O was/O scored/O for/O categories/O suggesting/O the/O predominant/O influence/O of/O the/O left/O hemisphere/O ,/O e/O ./O g/O .,/O good/O ego/O functioning/O ,/O verbalization/O ,/O or/O the/O right/O hemisphere/O ,/O e/O ./O g/O .,/O music/O ,/O spatial/O salience/O ,/O bizarreness/O ./O
Innervation/O of/O the/O ventral/O diaphragm/O of/O the/O locust/O (/O Locusta/O migratoria/O )./O
Ectopic/O ACTH/I syndrome/O and/O medullary/O thyroid/O carcinoma/O ./O
A/O striking/O finding/O in/O all/O of/O the/O studies/O was/O a/O positive/O correlation/O between/O PI/O ACTH/I and/O MSH/I contents/O ./O
Chronic/O hypophosphatemia/O is/O the/O most/O common/O type/O of/O "/O resistant/O "/O rickets/O ./O
There/O was/O no/O correlation/O between/O serum/I LH/I and/O chronological/O or/O bone/O age/O in/O this/O age/O group/O ,/O which/O suggests/O that/O the/O correlation/O found/O is/O not/O due/O to/O age/O -/O related/O parallel/O phenomena/O ./O
Molecular/O neurochemistry/O of/O addictive/O drugs/O ./O
Efforts/O were/O made/O to/O determine/O the/O amount/O of/O time/O required/O for/O kidney/O lesions/O to/O develop/O and/O ,/O if/O possible/O ,/O to/O delineate/O the/O potential/O site/O of/O action/O of/O PBB/O ./O
Effect/O of/O succimer/O on/O the/O intensity/O of/O tricarboxylic/I acid/I dehydrogenase/I reactions/O in/O the/O brain/O of/O rats/O poisoned/O with/O mercuric/O chloride/O
Distribution/O and/O correlations/O of/O serum/O uric/O -/O acid/O in/O two/O French/O adult/O populations/O :/O 13/O ,/O 885/O men/O and/O 6/O ,/O 861/O women/O
The/O incidence/O of/O hepatitis/I B/I antigen/I following/O transfusion/O was/O about/O 2/O ./O 8/O per/O cent/O ./O
Technetium/O -/O 99m/O stannous/O pyrophosphate/O myocardial/O scintigrams/O were/O obtained/O in/O 138/O clinically/O stable/O patients/O 32/O ./O 7/O +/-/O 47/O ./O 3/O weeks/O (/O range/O 6/O to/O 260/O )/O after/O acute/O myocardial/O infarction/O ./O
A/O similar/O phenomenon/O has/O been/O reported/O in/O a/O few/O humans/O ./O
The/O decline/O in/O the/O activity/O of/O cytochrome/I oxidase/I ,/O peroxidase/I and/O in/O the/O lipid/O content/O of/O peripheral/O neutrophils/O was/O followed/O by/O a/O decrease/O in/O the/O phagocytic/O activity/O ./O
Treatment/O of/O 2/O patients/O with/O pseudohypoparathyroidism/O type/O I/O with/O vitamin/O -/O D/O -/O 3/O and/O 1/O alpha/O -/O Hydroxycholecalciferol/O consecutively/O resulted/O in/O a/O nonuniform/O response/O with/O regard/O to/O the/O normalisation/O of/O serum/O -/O calcium/O ./O
Workers/O with/O "/O sensitivity/O "/O to/O toluene/O diisocyanate/O (/O TDI/O )/O studied/O in/O depth/O in/O an/O attempt/O to/O determine/O mechanisms/O of/O bronchial/O hyperreactivity/O ./O
Total/O VO2/O was/O decreased/O in/O both/O groups/O during/O severe/O hypoxia/O but/O limb/O VO2/O was/O maintained/O in/O the/O beta/O -/O block/O group/O ./O beta/O -/O Block/O prevented/O the/O fall/O in/O total/O and/O limb/O peripheral/O resistance/O seen/O in/O severe/O hypoxia/O but/O did/O not/O alter/O the/O consistently/O more/O efficient/O utilization/O of/O total/O O2/O delivery/O shown/O by/O the/O limb/O in/O comparison/O to/O the/O whole/O body/O by/O higher/O O2/O extraction/O ratios/O and/O lower/O venous/O O2/O pressure/O ./O beta/I -/I Vasodilator/I receptors/I evidently/O played/O an/O active/O part/O in/O the/O vasodilatation/O seen/O during/O severe/O hypoxia/O ./O
Phenobarbital/O -/O induced/O alterations/O in/O the/O metabolism/O of/O [/O 3H/O ]/O vitamin/O D3/O by/O the/O perfused/O rachitic/O rat/O liver/O in/O vitro/O ./O
Modulation/O of/O 25/I -/I hydroxyvitamin/I D3/I -/I 24/I -/I hydroxylase/I by/O aminophylline/O :/O a/O cytochrome/I P/I -/I 450/I monooxygenase/I system/O ./O
In/O both/O these/O respects/O ,/O however/O ,/O the/O DBP/I mRNA/I resembles/O the/O late/O messengers/O of/O SV40/O and/O polyoma/O viruses/O ./O
Effect/O of/O corticosteroid/O -/O containing/O antirheumatic/O combination/O drugs/O on/O endogenous/O ACTH/I and/O cortisol/O production/O ./O
Serum/I ACTH/I did/O not/O respond/O to/O insulin/I and/O metyrapone/O ./O
Anatomy/O of/O the/O RNA/O and/O gene/O products/O of/O MC29/O and/O MH2/O ,/O two/O defective/O avian/O tumor/O viruses/O causing/O acute/O leukemia/O and/O carcinoma/O :/O evidence/O for/O a/O new/O class/O of/O transforming/O genes/O ./O
Bertioga/O (/O Guama/O group/O )/O and/O Anhembi/O (/O Bunyamwera/O group/O ),/O two/O new/O arboviruses/O isolated/O in/O Sao/O Paulo/O ,/O Brazil/O ./O
Gamma/I glutamyl/I transpeptidase/I activity/O was/O increased/O up/O to/O 15/O times/O above/O the/O upper/O normal/O limit/O in/O children/O ,/O who/O received/O aminopyrine/O for/O two/O weeks/O or/O longer/O ./O
XXI/O ./O
A/O gas/O -/O liquid/O chromatographic/O method/O for/O the/O determination/O of/O p/O -/O chlorophenoxyisobutyric/O (/O CPIB/O )/O acid/O in/O blood/O plasma/O is/O described/O ./O
Dopamine/I receptor/I blockade/O and/O the/O neuroleptics/O ,/O a/O crystallographic/O study/O ./O
V/O ./O
A/O rapid/O fluorimetric/O procedure/O for/O the/O determination/O of/O the/O fungicide/O 5/O -/O fluorocytosine/O in/O serum/O is/O described/O ./O
The/O '/O field/O of/O stress/O '/O of/O the/O supervisory/O nurse/O
How/O do/O graduates/O of/O different/O types/O of/O programs/O perform/O on/O state/O boards/O ?/O
Similarly/O ,/O maternal/I serum/I somatomedin/I A/I was/O significantly/O reduced/O in/O rats/O nursing/O large/O litters/O ./O
The/O sequences/O following/O the/O X/O ./O borealis/O oocyte/O and/O somatic/O 5S/I genes/I are/O identical/O in/O 12/O of/O the/O first/O 14/O residues/O and/O contain/O two/O or/O more/O T/O clusters/O ,/O as/O does/O the/O corresponding/O region/O of/O X/I ./I laevis/I oocyte/I 5S/I DNA/I ./O
This/O mechanism/O is/O not/O due/O to/O the/O observed/O grain/O boundary/O precipitates/O ./O
This/O report/O has/O reviewed/O some/O of/O the/O reasons/O for/O treatment/O failures/O and/O has/O presented/O a/O philosophy/O for/O their/O management/O ./O
Diagnosis/O and/O treatment/O planning/O in/O Class/O II/O ,/O division/O 2/O
Because/O of/O serious/O infections/O (/O fever/O larger/O than/O or/O equal/O to/O 101/O degrees/O F/O ./O granulocytes/O less/O than/O 1/O ,/O 000/O //O mm/O ,/O 3/O and/O hospitalization/O )/O and/O 1/O drug/O death/O in/O the/O first/O 4/O patients/O ,/O oral/O calcium/O leucovorin/O ,/O 20/O to/O 30/O mg/O //O m2/O orally/O ,/O was/O given/O 2/O days/O after/O methotrexate/O in/O subsequent/O treatment/O cycles/O ./O
It/O seems/O that/O the/O way/O in/O which/O drugs/O modify/O a/O patient/O '/O s/O serum/O chemistry/O may/O be/O used/O to/O assess/O the/O efficacy/O with/O which/O they/O control/O the/O inflammatory/O process/O ./O
Here/O the/O conventional/O tests/O clearly/O pointed/O to/O the/O presence/O of/O retrocochlear/O disease/O ./O
The/O end/O -/O stage/O or/O involutional/O phase/O of/O proliferative/O diabetic/O retinopathy/O may/O result/O in/O stabilization/O of/O vision/O for/O long/O periods/O of/O time/O ./O
On/O the/O basis/O of/O serum/I alpha1AT/I quantitation/O ,/O newborn/O infants/O may/O be/O separated/O into/O two/O groups/O ,/O characterized/O respectively/O by/O concentrations/O above/O or/O below/O 150/O mg/O %./O
In/O patients/O who/O were/O not/O vented/O ,/O there/O was/O overall/O significant/O depression/O of/O function/O (/O 67/O +/-/O 5/O %/O of/O control/O ;/O range/O ,/O 91/O --/O 45/O %,/O p/O less/O than/O 0/O ./O 01/O )./O
Changes/O in/O body/O weight/O and/O agonistic/O behavior/O were/O also/O recorded/O ./O
The/O uterine/O response/O to/O prostaglandin/O E2/O (/O PGE2/O )/O and/O prostaglandin/O F2alpha/O (/O administered/O by/O intravenous/O and/O intrauterine/O routes/O )/O was/O evaluated/O during/O different/O phases/O of/O the/O menstrual/O cycle/O in/O five/O functionally/O infertile/O women/O ./O
A/O total/O of/O 26/O BCG/O strains/O ,/O out/O of/O them/O 10/O Czechoslovak/O strains/O (/O 2/O lyophilized/O cultures/O of/O BCG/O of/O different/O batch/O ,/O 6/O strains/O isolated/O from/O abscesses/O of/O children/O after/O BCG/O -/O vaccination/O and/O 2/O strains/O from/O fatal/O cases/O after/O BCG/O -/O vaccination/O )/O and/O 16/O strains/O obtained/O from/O foreign/O laboratories/O ,/O were/O used/O ./O
High/O levels/O of/O serum/O calcitonin/I were/O found/O in/O patients/O with/O chronic/O renal/O failure/O ./O
Detection/O of/O anti/O -/O lymphocyte/O antibodies/O using/O the/O immunoperoxidase/I antiglobulin/I technic/O ./O
The/O response/O of/O serum/I GH/I to/O arginine/O infusion/O was/O normal/O ,/O while/O that/O to/O insulin/I -/O induced/O hypoglycemia/O was/O poor/O ./O
The/O mortality/O rate/O and/O histopathological/O features/O of/O Nocardia/O asteroides/O and/O Nocardia/O brasiliensis/O infections/O in/O congenitally/O athymic/O (/O nude/O )/O mice/O of/O ICR/O and/O C3H/O //O eB/O origins/O were/O quite/O different/O from/O what/O we/O found/O for/O Swiss/O white/O mice/O and/O other/O inbred/O mouse/O strains/O (/O namely/O ,/O C57/O //O BL/O //O 6J/O ,/O New/O Zealand/O Black/O ,/O BALB/O //O c/O ,/O CBA/O //O LAC/O ,/O and/O C3H/O //O eB/O )./O
Williams/O ,/O 2/O August/O 1977/O ./O
Use/O of/O radioactive/O isotopes/O in/O the/O chemistry/O of/O proteins/O
(/O Emeritus/O )/O John/O Henri/O Roosegaarde/O Bisschop/O
Disrupted/O vaccines/O and/O whole/O -/O virus/O vaccines/O containing/O type/I B/I antigen/I only/O did/O not/O cause/O significant/O reactivity/O ./O
255/O -/O 61/O ./O
Antenatal/O diagnosis/O of/O haematological/O disorders/O --'/O 1978/O './O
Hepatic/O oxygen/O supply/O and/O selected/O blood/O parameters/O were/O recorded/O in/O fasted/O male/O rates/O given/O 20/O --/O 30/O mg/O //O kg/O Escherichia/I coli/I endotoxin/I intraperitoneally/O ./O
Gonadal/O dysfunction/O in/O patients/O with/O ataxia/O telangiectasia/O ./O
The/O maximum/O period/O of/O treatment/O was/O 73/O (/O oral/O ),/O 73/O (/O intraperitoneal/O )/O or/O 75/O (/O dermal/O )/O weeks/O ./O
A/O study/O of/O the/O comparative/O efficacy/O of/O diflucortolone/O valerate/O 0/O ./O 3/O %/O ointment/O and/O clobetasol/O propionate/O 0/O ./O 05/O %/O ointment/O ./O
Most/O of/O the/O phenomena/O of/O azotaemic/O osteodystrophy/O are/O encountered/O in/O simple/O vitamin/O D/O deficiency/O ;/O as/O in/O that/O condition/O ,/O deficiency/O of/O 1/O ,/O 25/O -/O dihydroxycholecalciferol/O may/O be/O of/O primary/O significance/O in/O causing/O secondary/O hyperparathyroidism/O in/O renal/O failure/O ./O
Basal/O FSH/I and/O LH/I levels/O were/O significantly/O lower/O in/O addicts/O ;/O after/O GnRH/I stimulation/O the/O addicts/O '/O FSH/I and/O LH/I values/O increased/O but/O not/O significantly/O compared/O to/O controls/O ./O
Adriamycin/O :/O comparison/O of/O a/O 5/O -/O week/O schedule/O with/O a/O 3/O -/O week/O schedule/O in/O the/O treatment/O of/O breast/O cancer/O ./O
Follow/O -/O up/O controls/O of/O luteinizing/I hormone/I (/O LH/I ),/O follicle/I stimulating/I hormone/I (/O FSH/I ),/O prolactin/I (/O HPRL/I ),/O oestradiol/O (/O E2/O ),/O progesterone/O (/O P/O )/O and/O testosterone/O (/O T/O )/O in/O the/O catabolic/O and/O healing/O phase/O of/O burn/O disease/O ./O
Renin/I studies/O performed/O in/O 34/O hypertensive/O patients/O and/O in/O a/O control/O group/O of/O 11/O recipients/O showed/O that/O elevation/O of/O plasma/I renin/I activity/O and/O of/O plasma/O aldosterone/O level/O is/O frequent/O but/O difficult/O to/O interpret/O ,/O particularly/O when/O a/O renal/O artery/O stenosis/O is/O observed/O ./O
A/O randomized/O clinical/O trial/O in/O sixty/O -/O two/O adult/O patients/O suffering/O from/O typhoid/O fever/O ,/O proved/O by/O blood/O and/O marrow/O culture/O ,/O showed/O that/O amoxycillin/O in/O a/O dosage/O schedule/O of/O 1/O g/O 8/O -/O hourly/O orally/O for/O fourteen/O days/O was/O better/O than/O chloramphenicol/O with/O regard/O to/O clinical/O and/O temperature/O response/O and/O in/O respect/O of/O carriers/O and/O relapse/O rates/O ./O
202/O -/O 8/O ./O
Bone/O marrow/O transplantation/O -/O 1979/O ./O
In/O this/O article/O ,/O the/O clinical/O actions/O of/O the/O principal/O dopamine/I receptor/I stimulating/O agents/O (/O apomorphine/O and/O its/O derivatives/O ;/O piribedil/O ,/O rye/O -/O ergot/O derivatives/O )/O are/O discussed/O on/O the/O basis/O of/O their/O biochemical/O and/O pharmacological/O properties/O ./O
The/O unilateral/O vestibular/O hypofunction/O ./O
Thus/O ,/O the/O inhibition/O of/O pepsin/I in/O human/O gastric/O juice/O does/O not/O appear/O to/O have/O a/O major/O influence/O on/O the/O healing/O of/O duodenal/O ulcer/O ./O
The/O IDF/O standard/O method/O for/O the/O detection/O of/O penicillin/O in/O milk/O is/O not/O suitable/O for/O the/O detection/O of/O sulphonamide/O residues/O in/O milk/O ./O
Capsular/O antigens/O of/O Staphylococcus/O aureus/O
The/O course/O of/O endotoxin/O fever/O remained/O uninfluenced/O by/O ALS/O ./O
2/O new/O Algerian/O cases/O
Seventy/O -/O one/O percent/O of/O patients/O treated/O with/O ticarcillin/O alone/O responded/O favorably/O ./O
Accurate/O pathologic/O staging/O identifies/O patients/O who/O are/O potentially/O curable/O with/O radiotherapy/O ./O
Inherent/O hematology/O of/O old/O age/O
Neomycin/O is/O fairly/O effective/O against/O staphylococci/O ,/O less/O effective/O against/O streptococci/O ,/O and/O fairly/O effective/O against/O gram/O -/O negative/O intestinal/O organisms/O ./O
It/O was/O concluded/O ,/O that/O on/O a/O given/O section/O ,/O 75/O ,/O 7/O per/O cent/O of/O the/O trabeculae/O were/O in/O contact/O with/O vascular/O cavities/O ./O
2/O ./O
Changes/O in/O tissue/O PCO2/O were/O less/O dramatic/O and/O did/O not/O vary/O significantly/O from/O those/O recorded/O in/O venous/O blood/O ./O
Ultrasonic/O evaluation/O of/O renal/O calculi/O ./O
Recognition/O of/O emphysema/O was/O poor/O when/O radiographs/O of/O inadequate/O quality/O were/O included/O (/O anteroposterior/O films/O or/O films/O from/O patients/O with/O acute/O or/O chronic/O lung/O disease/O )./O
Isolation/O of/O T/O ./O gambiense/O strains/O in/O Zaire/O and/O their/O adaptation/O to/O laboratory/O animals/O
Pharmacokinetic/O profile/O of/O clonazepam/O in/O rhesus/O monkeys/O ./O
Immunologic/O mechanisms/O in/O chronic/O brucellosis/O in/O humans/O ./O
Intestinal/O adaptation/O (/O first/O of/O two/O parts/O )./O
In/O patients/O who/O had/O received/O no/O previous/O drug/O treatment/O ,/O log/O baseline/O plasma/I renin/I activity/O and/O change/O in/O mean/O blood/O pressure/O after/O SQ/O 20881/O correlated/O significantly/O (/O r/O =/O 0/O ./O 651/O ,/O P/O less/O than/O 0/O ./O 05/O )./O
These/O techniques/O have/O been/O used/O by/O many/O people/O for/O many/O years/O and/O no/O claim/O is/O being/O made/O for/O any/O innovation/O in/O this/O regard/O ./O
40/O patients/O with/O chronic/O osteomyelitis/O were/O treated/O per/O os/O with/O the/O bactericidal/O beta/O -/O lactam/O -/O antibiotic/O cephalexin/O during/O 3/O to/O 60/O weeks/O ./O
A/O total/O of/O 57/O patients/O with/O Hodgkin/O '/O s/O disease/O limited/O to/O above/O the/O diaphragm/O (/O Stages/O I/O and/O II/O ,/O A/O and/O B/O )/O were/O treated/O with/O radiation/O therapy/O alone/O at/O the/O University/O of/O Florida/O between/O 1964/O and/O 1974/O ./O
Year/O one/O of/O the/O first/O general/O practitioner/O medical/O unit/O in/O the/O greater/O Glasgow/O area/O ./O
This/O multiple/O -/O electrode/O array/O for/O round/O window/O cochlear/O implantation/O is/O a/O robust/O ,/O reliable/O system/O for/O inserting/O 20/O mm/O along/O the/O scala/O tympani/O with/O a/O minimum/O of/O trauma/O and/O can/O provide/O for/O bipolar/O stimulation/O ./O
As/O authorized/O by/O the/O World/O Health/O Organization/O 29th/O Expert/O Committee/O on/O Biological/O Standardization/O ,/O the/O preparation/O of/O human/I prolactin/I in/O ampoules/O coded/O 75/O //O 504/O has/O been/O established/O as/O the/O International/O Reference/O Preparation/O (/O IRP/O )/O of/O human/I prolactin/I for/O immunoassay/O ./O
i/O ./O
Biliary/O -/O enteric/O fistulas/O
Plasma/O ion/O changes/O in/O venous/O blood/O incubated/O with/O beta/I receptor/I blockers/O and/O subjected/O to/O tonometry/O in/O vitro/O ./O
Such/O marked/O differences/O are/O found/O occasionally/O in/O the/O literature/O :/O heterophile/O antibodies/O against/O bovine/I gammaglobulin/I are/O regarded/O as/O responsible/O for/O the/O interference/O in/O the/O Sephadex/O system/O of/O RIST/O ./O
"/O Let/O the/O hundred/O flowers/O bloom/O "./O
Various/O treatment/O modalities/O are/O reviewed/O in/O the/O context/O of/O the/O psychology/O as/O well/O as/O the/O physiology/O of/O severe/O intractable/O pain/O ./O
Lethal/O Tachmalcor/O (/O 4/O -(/O 3/O '-/O diethylamino/O -/O 2/O '-/O hydroxypropyl/O )-/O ajmaline/O )/O poisoning/O in/O childhood/O
Ophthalmosonographic/O evaluation/O of/O blood/O flow/O velocity/O in/O arteriocavernous/O fistula/O
Serum/O ferritin/I concentration/O and/O bone/O marrow/O iron/O stores/O ./O
The/O systolic/O pressure/O gradient/O (/O SPG/O )/O between/O the/O left/O ventricle/O (/O LV/O )/O and/O left/O atrium/O (/O LA/O )/O was/O obtained/O from/O high/O -/O fidelity/O pressure/O transducers/O ./O
A/O prospective/O trail/O comparing/O hysterectomy/O ,/O hysterectomy/O plus/O vaginal/O radium/O ,/O and/O uterine/O radium/O plus/O hysterectomy/O in/O stage/O I/O endometrial/O carcinoma/O ./O
On/O the/O basis/O of/O a/O patient/O '/O s/O report/O of/O one/O inaccurate/O Clinitemp/O ,/O we/O undertook/O to/O investigate/O the/O accuracy/O of/O this/O thermometer/O ./O
Cryoglobulinemia/O in/O Raynaud/O '/O s/O syndrome/O
Data/O were/O processed/O with/O a/O semi/O -/O automatic/O computer/O program/O which/O develops/O an/O averaged/O -/O volume/O curve/O from/O an/O assigned/O LV/O region/O -/O of/O -/O interest/O ./O
The/O preferential/O serum/I IgA/I response/O observed/O in/O the/O patient/O population/O suggests/O that/O bronchial/O associated/O lymphoid/O tissue/O in/O the/O diseased/O lung/O is/O an/O important/O source/O of/O circulating/O IgA/I ./O
Ultimate/O strengthes/O seem/O to/O be/O reached/O for/O cast/O cobalt/O alloys/O ,/O whereas/O titanium/O alloys/O ,/O such/O as/O Ta/O 6/O V/O ,/O present/O very/O high/O fatigue/O limit/O under/O corrosion/O ./O
The/O effects/O of/O intracisternal/O injection/O (/O i/O ./O c/O ./O i/O .)/O of/O clonidine/O (/O 1/O microgram/O kg/O -/O 1/O )/O on/O blood/O pressure/O and/O heart/O rate/O were/O studied/O in/O conscious/O rabbits/O with/O an/O implanted/O catheter/O in/O the/O cisterna/O magna/O ./O
Platelet/O number/O and/O life/O span/O were/O determined/O in/O the/O last/O trimester/O of/O pregnancy/O in/O 22/O women/O who/O were/O delivered/O of/O small/O -/O for/O -/O gestational/O age/O (/O SGA/O )/O infants/O and/O in/O 21/O women/O with/O infants/O having/O normal/O birth/O weights/O ./O
Serial/O measurements/O of/O total/O serum/O IgE/I appears/O to/O be/O a/O useful/O index/O of/O disease/O activity/O in/O ABPA/O ./O
In/O the/O 8/O patients/O the/O difference/O betweent/O he/O mean/O diastolic/O values/O of/O delta/O PU/O and/O delta/O PM/O was/O -/O 0/O ./O 54/O +/-/O 1/O ./O 0/O (/O SD/O )/O mmHg/O ./O
A/O rise/O of/O hemoglobin/I concentration/O accompanied/O by/O an/O increase/O of/O the/O total/O iron/O in/O the/O blood/O serum/O of/O white/O mice/O was/O found/O under/O oxygen/O pressure/O of/O 4/O atm/O for/O an/O hour/O (/O preconvulsive/O state/O )/O and/O 6/O atm/O (/O convulsive/O state/O )./O
Nernst/O --/O Planck/O analog/O equations/O and/O stationary/O state/O membrane/O electric/O potentials/O ./O
Effects/O of/O methylene/O chloride/O ,/O trichloroethane/O ,/O trichloroethylene/O ,/O tetrachloroethylene/O and/O toluene/O on/O the/O development/O of/O chick/O embryos/O ./O
Effect/O of/O intraventricular/O administration/O of/O streptolysin/I O/I on/O the/O electroencephalogram/O of/O rabbits/O ./O
In/O this/O situation/O the/O convlusion/O threshold/O for/O the/O 8/O substances/O is/O as/O follows/O :/O pethidine/O 20/O mg/O ./O kg/O -/O 1/O I/O ./O V/O .,/O piritramide/O 30/O ,/O morphine/O 180/O ,/O phenoperidine/O 4/O ,/O R/O 39/O 209/O 5/O ,/O fentanyl/O 4/O ,/O sufentanil/O 4/O and/O R/O 34/O 995/O 10/O mg/O ./O kg/O -/O 1/O I/O ./O V/O ./O
The/O biochemistry/O of/O amniotic/O fluid/O with/O poor/O fetal/O growth/O ./O
Roentgenographically/O ,/O the/O lesion/O was/O usually/O a/O well/O -/O defined/O and/O benign/O appearing/O one/O ,/O either/O purely/O lytic/O (/O 3/O cases/O )/O or/O with/O central/O radiodensity/O (/O 2/O cases/O )./O
Effects/O of/O chronic/O descending/O tractotomy/O on/O the/O response/O patterns/O of/O neurons/O in/O the/O trigeminal/O nuclei/O principalis/O and/O oralis/O ./O
Efficacy/O of/O a/O three/O -/O versus/O a/O five/O -/O week/O alcohol/O treatment/O program/O ./O
Resistance/O to/O the/O simulated/O physiologic/O environment/O was/O tested/O by/O measured/O retention/O of/O mechanical/O properties/O after/O immersion/O times/O in/O pseudo/O -/O extracellular/O fluid/O (/O PECF/O )/O at/O 37/O degrees/O C/O for/O as/O long/O as/O three/O years/O ./O
Isolated/O calcaneal/O tuberculous/O osteomyelitis/O ./O
It/O is/O concluded/O that/O opiate/I receptors/I bordering/O the/O fourth/O cerebral/O ventricle/O mediate/O the/O cardiovascular/O and/O hypnotic/O action/O of/O fentanyl/O ./O
In/O case/O of/O a/O pathologically/O convoluted/O internal/O carotid/O the/O common/O carotid/O artery/O was/O resected/O with/O an/O end/O -/O to/O -/O end/O anastomosis/O ./O
This/O expression/O assumes/O :/O (/O 1/O )/O a/O laminar/O flow/O regimen/O during/O expiration/O ,/O and/O (/O 2/O )/O a/O constant/O CT/O value/O over/O the/O range/O of/O VT/O ./O
These/O data/O confirm/O the/O existence/O of/O hyperlipemic/O abdominal/O crisis/O as/O a/O distinct/O entity/O and/O testify/O to/O the/O importance/O of/O recognizing/O this/O syndrome/O in/O order/O to/O avoid/O the/O occurrence/O of/O acute/O pancreatitis/O and/O the/O performance/O of/O unnecessary/O and/O potentially/O harmful/O surgery/O ./O
In/O addition/O a/O significant/O Treatment/O X/O Strain/O interaction/O was/O due/O to/O the/O larger/O defecation/O numbers/O displayed/O by/O the/O taurine/O -/O injected/O MR/O rats/O relative/O to/O the/O saline/O -/O injected/O MR/O rats/O ./O
Their/O conduction/O velocity/O ranged/O from/O 0/O ./O 23/O to/O 0/O ./O 98/O m/O //O sec/O (/O group/O C/O )./O
The/O failures/O frequently/O were/O related/O to/O patient/O intolerance/O or/O poor/O mechanical/O fit/O and/O occurred/O in/O the/O first/O few/O days/O or/O first/O few/O months/O after/O insertion/O ./O
The/O major/O urinary/O metabolites/O were/O 3/O -(/O 3/O -/O carboxyphenyl/O )-/O 5/O -/O hydroxymethyl/O -/O 2/O -/O oxazolidinone/O and/O a/O glucuronide/O of/O toloxatone/O ./O
These/O characteristics/O indicated/O the/O pronounced/O activity/O of/O collagenous/O fiber/O synthesis/O and/O the/O matrix/O of/O the/O osteoid/O tissue/O ./O
The/O ventilation/O did/O not/O increase/O when/O PACO2/O was/O increased/O ./O
Carbohydrate/O metabolism/O and/O the/O semen/O profile/O :/O glucose/O ,/O insulin/I ,/O and/O sperm/O studies/O ./O
It/O has/O come/O out/O that/O CAEC/O is/O between/O CC/O and/O CIEC/O and/O that/O attacks/O of/O biliary/O fever/O and/O high/O levels/O of/O alkaline/I phosphatase/I and/O transaminases/O in/O the/O serum/O are/O the/O helpful/O findings/O for/O preoperative/O diagnosis/O ./O
The/O sub/O -/O acute/O inhalation/O toxicity/O of/O furfural/O was/O studied/O in/O Syrian/O golden/O hamsters/O ./O
Changes/O of/O thirtynine/O serum/O protein/O components/O following/O surgical/O stress/O ./O
These/O differences/O are/O smaller/O than/O those/O described/O in/O standard/O textbooks/O ./O
A/O study/O of/O the/O E/O ./O O/O ./O R/O ./O T/O ./O C/O ./O
The/O present/O study/O examined/O the/O dependence/O of/O difference/O tone/O level/O [/O L/O (/O f2/O -/O f1/O )]/O on/O the/O following/O parameters/O of/O the/O two/O -/O tone/O input/O :/O f1/O ,/O f2/O //O f1/O (/O f2/O greater/O than/O f1/O ),/O L1/O ,/O L2/O ,/O and/O L1/O =/O L2/O ./O
An/O intravenous/O preparation/O of/O doxycycline/O (/O DOTC/O ,/O Vibramycin/O '/O Pfizer/O '),/O a/O long/O -/O lasting/O tetracycline/O ,/O was/O administered/O mainly/O by/O drip/O infusion/O for/O a/O series/O of/O study/O in/O the/O pediatrics/O field/O ,/O and/O the/O results/O were/O as/O follows/O :/O 1/O )/O DOTC/O (/O 100/O mg/O )/O was/O dissolved/O in/O a/O 100/O ml/O of/O glucose/O solution/O and/O 2/O --/O 3/O mg/O //O kg/O was/O administered/O intravenously/O ./O
5/O )/O Before/O and/O ten/O days/O after/O DOTC/O infusion/O ,/O laboratory/O tests/O for/O liver/O and/O renal/O functions/O and/O blood/O were/O performed/O ./O
Structural/O characteristics/O of/O the/O erythrocyte/O membrane/O ,/O peroxidation/O processes/O and/O antioxidant/O function/O in/O children/O with/O diffuse/O glomerulonephritis/O
The/O enteric/O route/O is/O the/O principal/O mode/O of/O transmission/O for/O hepatitis/O A/O ,/O but/O maximal/O levels/O of/O hepatitis/O A/O virus/O excretion/O occur/O before/O the/O onset/O of/O jaundice/O ./O
All/O 13/O patients/O showed/O endoscopic/O evidence/O of/O oesophagitis/O ,/O moderate/O in/O 4/O and/O severe/O in/O 9/O ./O
Urinary/O excretion/O of/O oestrone/O ,/O oestradiol/O -/O 17/O beta/O and/O oestriol/O in/O pregnancies/O complicated/O by/O steroid/I sulphatase/I deficiency/O ./O
Both/O reduced/O spontaneous/O locomotor/O activity/O in/O mice/O ,/O protected/O them/O from/O death/O from/O amphetamine/O induced/O toxicity/O ,/O prolonged/O hexobarbitone/O sleeping/O time/O and/O caused/O a/O depletion/O of/O catecholamines/O from/O various/O organs/O of/O the/O rat/O ./O
On/O the/O role/O of/O transferrin/I in/O the/O uptake/O of/O gallium/O by/O tumor/O cells/O ./O
Irradiation/O of/O human/O blood/O platelets/O with/O UV/O -/O A/O in/O vitro/O impairs/O their/O ability/O to/O aggregate/O after/O challenge/O with/O collagen/I ./O
With/O certain/O exceptions/O the/O method/O was/O considered/O suitable/O in/O the/O routine/O intravenous/O cholangiography/O ./O
Following/O the/O satisfactory/O results/O and/O taking/O into/O account/O that/O the/O complications/O had/O reduced/O to/O a/O very/O low/O rate/O (/O in/O 2/O cases/O lead/O tip/O displacement/O and/O pouch/O haematoma/O occurred/O respectively/O ),/O the/O Authors/O consider/O the/O adopted/O method/O an/O useful/O approach/O for/O PMK/O implantation/O particularly/O when/O the/O use/O of/O the/O vena/O cephalica/O is/O deemed/O impossible/O ./O
When/O two/O determinations/O were/O performed/O on/O 12/O samples/O of/O plasma/O taken/O from/O normal/O adults/O in/O October/O ,/O the/O values/O were/O 22/O ./O 6/O +/-/O 4/O ./O 8/O and/O 21/O ./O 0/O +/-/O 3/O ./O 6/O (/O mean/O +/-/O SD/O )/O ng/O //O ml/O ,/O respectively/O ./O
The/O six/O commonest/O causes/O of/O death/O varied/O in/O the/O three/O ethnic/O groups/O ./O
Although/O Grice/O '/O s/O operation/O has/O been/O used/O all/O over/O the/O world/O ,/O no/O systematic/O account/O of/O it/O has/O been/O found/O in/O the/O literature/O (/O including/O publications/O dealing/O with/O technique/O ),/O which/O presents/O it/O in/O terms/O related/O to/O the/O basic/O "/O classical/O "/O principles/O on/O which/O the/O operation/O was/O conceived/O ./O
(/O 5/O )/O No/O changes/O were/O observed/O in/O the/O gastric/O venous/O blood/O flow/O by/O continuous/O intravenous/O injection/O of/O cimetidine/O ,/O but/O by/O rapid/O injection/O both/O the/O flow/O was/O augmented/O and/O the/O systemic/O blood/O pressure/O decreased/O transiently/O ./O
Study/O on/O re/O -/O establishment/O of/O ovulation/O after/O termination/O of/O sex/O -/O steroidal/O treatment/O --/O compared/O with/O re/O -/O appearance/O of/O ovulation/O after/O abortion/O and/O premature/O delivery/O ./O
Pharmacokinetics/O of/O Carbamazepine/O in/O man/O :/O a/O review/O ./O
Of/O the/O compounds/O tested/O ,/O alpha/O -(/O 3/O -/O methyl/O -/O 2/O -/O quinoxalinyl/O )-/O N/O -/O methylnitrone/O 1/O ,/O 4/O -/O dioxide/O (/O 2/O )/O was/O the/O most/O active/O agent/O in/O vivo/O against/O the/O gram/O -/O negative/O and/O the/O gram/O -/O positive/O organisms/O ./O
Changes/O in/O ionic/O content/O of/O the/O mucous/O suggest/O that/O cholinergic/O mechanisms/O affect/O pressure/O in/O the/O excretory/O duct/O of/O the/O gland/O ./O
Calves/O fed/O MCT/O -/O milk/O had/O significantly/O lower/O blood/O cholesterol/O than/O calves/O fed/O T/O -/O or/O SBO/O -/O milk/O ./O
Delayed/O mortality/O of/O mice/O following/O inhalation/O of/O acute/O doses/O of/O CH2O/O ,/O SO2Cl2/O ,/O and/O Br2/O ./O
Guinea/O pigs/O weighing/O 300/O approximately/O 350/O g/O were/O used/O ./O
Under/O halothane/O anesthesia/O ,/O the/O flow/O pneumocardiogram/O (/O PnCG/O )/O and/O its/O time/O derivative/O (/O acceleration/O pneumocardiogram/O or/O dPn/O //O dt/O )/O were/O transduced/O during/O apnea/O by/O a/O small/O high/O -/O gain/O pneumotachograph/O ./O
Sensory/O kindling/O :/O implications/O for/O development/O of/O sensory/O prostheses/O ./O
It/O is/O concluded/O that/O stereotypy/O can/O be/O evoked/O also/O in/O the/O case/O when/O the/O striatal/O dopaminergic/O tone/O is/O normal/O or/O even/O below/O normal/O :/O it/O is/O the/O equilibrium/O of/O the/O striatal/O cholinergic/O -/O dopaminergic/O systems/O which/O must/O be/O shifted/O towards/O dopamine/O ,/O which/O is/O necessary/O for/O the/O development/O of/O this/O behavioral/O manifestation/O ./O
None/O of/O the/O cystometrograms/O showed/O uninhibited/O detrusor/O contractions/O ./O
In/O the/O duodenum/O a/O small/O part/O of/O the/O administered/O dose/O was/O transformed/O to/O 3H/O -/O alpha/O -/O acetyldigoxin/O ./O
Functional/O effects/O following/O subacute/O administration/O ./O
Treatment/O of/O Graves/O '/O disease/O ./O
Although/O it/O has/O been/O shown/O that/O it/O is/O possible/O to/O use/O orally/O administered/O testosterone/O to/O maintain/O se/O -/O T/O levels/O in/O the/O normal/O male/O range/O ,/O the/O convenience/O to/O the/O patient/O must/O be/O balanced/O against/O the/O cost/O and/O possible/O side/O effects/O of/O the/O large/O doses/O required/O ./O
Contrary/O to/O 1/O ,/O 8/O -/O dihydroxy/O -/O 9/O -/O anthrone/O ,/O 1/O ,/O 8/O ,/O 9/O -/O triacetoxyanthracene/O and/O 1/O ,/O 8/O -/O diacetoxy/O -/O 9/O -/O anthrone/O are/O effective/O against/O psoriatic/O lesions/O without/O accompanying/O inflammations/O of/O the/O skin/O ./O
Etiopathogenetic/O and/O therapeutic/O problems/O in/O acute/O orbital/O inflammation/O
Nursing/O of/O patients/O with/O gynecological/O diseases/O
We/O measured/O basal/O plasma/O prolactin/I concentrations/O (/O in/O samples/O obtained/O during/O the/O early/O follicular/O phase/O )/O in/O 25/O normal/O (/O control/O )/O women/O and/O in/O a/O similar/O group/O of/O 40/O patients/O with/O a/O long/O -/O standing/O history/O of/O infertility/O ./O
Ovarian/O allotransplantation/O in/O human/O ./O
Allergic/O reaction/O to/O Patent/O Blue/O Violet/O during/O lymphography/O ./O
Screening/O of/O asthma/O patients/O by/O determination/O of/O IgE/I and/O by/O comprehension/O of/O spectrum/O of/O allergospecific/I IgE/I antibodies/I
The/O induction/O of/O seizures/O in/O "/O Papio/O papio/O "/O following/O allylglycine/O alone/O or/O in/O combination/O with/O intermittent/O photic/O stimulation/O
A/O highly/O significant/O correlation/O was/O found/O between/O the/O presence/O of/O fibrinolytic/O degradation/O products/O (/O FDP/O )/O and/O the/O incidence/O of/O nephropathy/O and/O renal/O insufficiency/O ,/O as/O well/O as/O between/O the/O presence/O of/O fibrin/I monomers/I (/O Godal/O '/O s/O ethanol/O -/O gelification/O test/O )/O and/O the/O evolutive/O signs/O of/O the/O primary/O disease/O (/O fever/O ,/O accelerated/O ESR/O )./O
One/O -/O third/O of/O the/O men/O with/O azoospermia/O and/O with/O sperm/O density/O of/O less/O than/O 10/O million/O had/O marked/O FSH/I elevation/O and/O our/O experience/O confirms/O the/O work/O of/O others/O that/O this/O indicates/O a/O poor/O prognosis/O ./O
In/O girls/O prolactin/I levels/O rise/O at/O stage/O 2/O ,/O and/O are/O higher/O after/O menarche/O ;/O in/O boys/O there/O is/O no/O change/O in/O prolactin/I levels/O ./O
It/O was/O concluded/O that/O both/O of/O these/O surgical/O procedures/O were/O as/O effective/O as/O pinealectomy/O in/O reversing/O the/O pineal/O -/O induced/O alterations/O in/O the/O reproductive/O physiology/O of/O the/O blind/O -/O anosmic/O female/O rat/O ./O
2/O cases/O of/O toxic/O lymphomononucleosis/O
Such/O an/O hemoglobin/I solution/O was/O shown/O to/O exhibit/O a/O high/O affinity/O for/O oxygen/O and/O a/O low/O Bohr/O effect/O (/O assessed/O from/O the/O delta/O log/O Po2/O //O delta/O pH/O ratio/O )./O
A/O one/O -/O week/O ulcer/O therapy/O with/O atropine/O and/O Vikalin/O (/O Roter/O )/O led/O to/O a/O significant/O (/O p/O less/O than/O 0/O ./O 01/O )/O reduction/O of/O the/O nocturnal/O proteolytic/O activity/O ./O
In/O one/O patient/O with/O severe/O diarrhea/O the/O estriol/O concentration/O in/O serum/O was/O low/O until/O the/O intestinal/O function/O normalised/O and/O the/O estriol/O concentration/O went/O up/O exactly/O when/O the/O diarrhea/O stopped/O ./O
Serum/O levels/O of/O IgG/I and/O IgM/I were/O also/O raised/O ,/O but/O contrary/O to/O the/O findings/O of/O other/O observers/O IgA/I levels/O were/O normal/O ./O
Experimental/O ischemic/O heart/O disease/O induced/O by/O thromboxane/O A2/O in/O rabbits/O ./O
Vitrectomy/O in/O ocular/O traumatology/O
To/O study/O the/O sensitivity/O of/O some/O central/O brain/O structures/O to/O the/O action/O of/O an/O electromagnetic/O field/O of/O decimeter/O waves/O (/O EMF/O of/O DW/O )/O a/O dynamic/O investigation/O of/O single/O unit/O activity/O was/O undertaken/O ./O
No/O systematic/O L/O -/O R/O differences/O were/O observed/O ./O
A/O decrease/O of/O the/O lysozyme/I activity/O coincided/O with/O the/O clinical/O improvement/O of/O the/O bacterial/O meningitis/O ./O
This/O implies/O that/O the/O groups/O do/O not/O just/O differ/O along/O one/O dimension/O ,/O but/O along/O three/O dimensions/O ./O
Deep/O tans/O were/O induced/O over/O the/O backs/O of/O volunteers/O with/O repeated/O exposure/O to/O longwave/O ultraviolet/O radiation/O (/O UV/O -/O A/O )./O
1/O The/O effects/O in/O normal/O subjects/O of/O a/O single/O oral/O dose/O of/O Motival/O (/O one/O tablet/O ,/O containing/O fluphenazine/O 0/O ./O 5/O mg/O and/O nortriptyline/O 10/O mg/O )/O on/O the/O contingent/O negative/O variation/O (/O CNV/O ),/O reaction/O time/O ,/O heart/O rate/O ,/O blood/O pressure/O and/O self/O -/O rating/O scales/O for/O alertness/O ,/O anxiety/O ,/O tension/O ,/O detachment/O and/O depression/O were/O compared/O with/O those/O of/O diazepam/O (/O 5/O mg/O and/O 7/O ./O 5/O mg/O )/O and/O placebo/O or/O propranolol/O (/O 60/O mg/O )./O
Stress/O effects/O on/O affiliation/O preferences/O among/O subjects/O possessing/O the/O type/O A/O coronary/O -/O prone/O behavior/O pattern/O ./O
These/O show/O that/O the/O collagen/I in/O this/O tissue/O is/O modified/O compared/O with/O that/O in/O tendon/O ./O
Smoking/O was/O regarded/O as/O the/O major/O contribution/O to/O pulmonary/O dysfunction/O ./O
The/O malignity/O of/O nevoid/O lentigo/O ./O
Elimination/O of/O bagassosis/O in/O Louisiana/O paper/O manufacturing/O plant/O workers/O ./O
These/O responses/O were/O compared/O with/O others/O in/O the/O same/O subjects/O under/O the/O same/O conditions/O and/O it/O was/O concluded/O that/O the/O antihypertensive/O effect/O of/O labetalol/O is/O explained/O by/O concurrent/O blockade/O of/O alpha/I -/I and/I beta/I -/I adrenoceptors/I ./O
Diuretics/O :/O basic/O clinical/O pharmacology/O and/O therapeutic/O use/O ./O
Three/O patients/O with/O four/O renoureteral/O units/O have/O undergone/O single/O -/O stage/O reconstruction/O involving/O ureteroureterostomy/O and/O ipsilateral/O ureteroneocystostomy/O following/O temporary/O loop/O cutaneous/O ureterostomy/O ./O
Evaluation/O of/O the/O Du/O Pont/O aca/O ammonia/O procedure/O ./O
Internally/O oriented/O patients/O '/O scores/O on/O Rotter/O '/O s/O Internal/O -/O External/O Locus/O of/O Control/O Scale/O remained/O the/O same/O over/O treatment/O but/O those/O of/O externally/O oriented/O patients/O shifted/O toward/O greater/O internal/O control/O ./O
Action/O of/O strontium/O -/O 90/O and/O metaphos/O on/O Cyprinus/O carpio/O
Kodak/O XV/O -/O 2/O film/O is/O wrapped/O around/O a/O cylindrical/O water/O -/O filled/O phantom/O and/O the/O dose/O distribution/O is/O recorded/O ./O
Diagnosis/O and/O differential/O diagnosis/O
The/O multiple/O factors/O affecting/O plasma/O renin/I activity/O in/O essential/O hypertension/O ./O
Cortisone/O induced/O bone/O changes/O and/O its/O response/O to/O lipid/O clearing/O agents/O ./O
2/O )/O The/O time/O -/O sharing/O principle/O was/O applied/O to/O gain/O high/O stability/O ./O
When/O blood/O samples/O of/O patients/O with/O hyperbilirubinemia/O were/O analyzed/O ,/O direct/O measurement/O of/O ZPP/O by/O this/O fluorimeter/O yielded/O significantly/O higher/O levels/O than/O did/O an/O alternate/O extraction/O method/O ./O
Delayed/O hypersensitivity/O in/O man/O :/O effects/O of/O systemic/O anticoagulation/O ./O
In/O three/O of/O the/O seven/O ,/O inhalation/O of/O 2/O ml/O normal/O saline/O produced/O FEV1/O falls/O of/O 25/O %/O to/O 30/O %,/O but/O these/O falls/O were/O not/O as/O great/O as/O each/O subject/O '/O s/O reactions/O to/O the/O test/O solutions/O ./O
Experimental/O studies/O on/O virus/O excretion/O and/O non/O -/O arthropod/O transmission/O ./O
Potency/O of/O enflurane/O in/O dogs/O :/O comparison/O with/O halothane/O and/O isoflurane/O ./O
Prevention/O of/O acute/O paraquat/O toxicity/O in/O rats/O by/O superoxide/I dismutase/I ./O
Measurement/O of/O magnesium/O absorption/O in/O man/O using/O stable/O 26Mg/O as/O a/O tracer/O ./O
Increased/O urinary/O riboflavin/O excretion/O resulting/O from/O boric/O acid/O ingestion/O ./O
Radionuclide/O angiography/O and/O static/O whole/O body/O imaging/O performed/O with/O technetium/O -/O 99m/O -/O labeled/O particulates/O can/O clearly/O demonstrate/O differential/O shunting/O in/O patients/O with/O patent/O ductus/O arteriosus/O (/O PDA/O )/O with/O Eisenmenger/O physiology/O ./O
Looming/O detectors/O in/O the/O human/O visual/O pathway/O ./O
Escherichia/O of/O a/O single/O sero/O -/O anzymatic/O type/O (/O 06a6b/O :/O K13/O :/O H1/O )/O were/O isolated/O in/O a/O group/O affection/O ./O
The/O method/O described/O may/O prove/O useful/O in/O studying/O the/O physiology/O of/O the/O nasal/O cycle/O ./O
At/O the/O same/O time/O we/O obtained/O easily/O understandable/O EEG/O -/O information/O which/O has/O never/O previously/O been/O available/O to/O us/O ./O
Analysis/O of/O liver/O biopsy/O specimens/O from/O patients/O with/O hepatitis/O showed/O a/O large/O variation/O in/O the/O mean/O iron/O content/O of/O the/O liver/O ferritin/I molecules/O ./O
Female/O mice/O were/O significantly/O more/O resistant/O to/O infection/O than/O males/O ./O
During/O the/O following/O 9/O 1/O //O 2/O years/O three/O sequential/O liver/O biopsies/O were/O performed/O ./O
Angiotensin/I effect/O in/O the/O human/O kidney/O ./O
Procion/O yellow/O dye/O was/O injected/O intracellularly/O into/O large/O auditory/O fibers/O of/O goldfish/O to/O investigate/O the/O relationship/O between/O the/O response/O type/O of/O these/O fibers/O and/O their/O site/O of/O termination/O in/O the/O saccular/O macula/O ./O
Incidental/O findings/O in/O the/O epidermis/O and/O in/O the/O intraepidermal/O eccrine/O sweat/O duct/O units/O ./O
Silicosis/O mortality/O
These/O consisted/O of/O beading/O and/O strictures/O mainly/O of/O the/O intrahepatic/O biliary/O tree/O (/O IHB/O )./O
Pentane/O and/O ethane/O ,/O which/O arise/O during/O lipid/O peroxidation/O in/O vivo/O ,/O were/O measured/O by/O gas/O chromatography/O in/O breath/O samples/O of/O rats/O fed/O for/O 8/O weeks/O a/O vitamin/O E/O -/O deficient/O diet/O to/O which/O had/O been/O added/O 0/O ,/O 11/O ,/O or/O 40/O IU/O vitamin/O E/O acetate/O per/O kg/O ./O
Thromboplastic/O and/O fibrynolytic/O activity/O of/O the/O blood/O after/O administration/O of/O intralipid/O in/O men/O with/O history/O of/O myocardial/O infarction/O up/O to/O 45/O year/O of/O life/O
The/O authors/O report/O the/O clinicopathologic/O findings/O in/O four/O cases/O of/O adult/O women/O with/O rhabdomyosarcomas/O that/O originated/O in/O the/O endometrium/O or/O cervix/O ,/O or/O both/O ./O
The/O effect/O of/O pure/O natural/O porcine/I secretin/I on/O endocrine/O and/O exocrine/O pancreatic/O secretion/O was/O studied/O in/O the/O totally/O isolated/O perfused/O porcine/O pancreas/O ./O
Biometric/O analysis/O of/O intraocular/O lens/O power/O required/O to/O produce/O emmetropia/O :/O results/O of/O 450/O implants/O ./O
Urine/O antibodies/O could/O not/O be/O demonstrated/O in/O any/O other/O cases/O ./O
Althoug/O RBF/O tended/O to/O increase/O after/O the/O therapy/O ,/O there/O was/O no/O statistically/O significant/O change/O in/O RBF/O ,/O GFR/O and/O cardiac/O output/O ./O
99mTc/O phytate/O ,/O 198Au/O colloid/O ,/O and/O 99mTc/O antimony/O sulfide/O have/O been/O used/O ;/O the/O last/O appears/O to/O have/O been/O the/O most/O satisfactory/O ./O
Six/O patients/O with/O glomerulonephritis/O in/O association/O with/O a/O ventriculovascular/O shunt/O were/O treated/O with/O three/O basic/O modes/O of/O therapy/O ./O
The/O mass/O of/O UO2/O in/O the/O extrapulmonary/O bronchi/O and/O first/O bifurcation/O decreased/O more/O slowly/O over/O 0/O --/O 8/O d/O after/O inhalation/O than/O the/O corresponding/O mass/O on/O the/O trachea/O ./O
Synovial/O cysts/O of/O the/O hip/O joint/O
A/O suspected/O hypothalamic/O dysfunction/O and/O a/O slightly/O impaired/O pituitary/O function/O manifested/O as/O GH/I deficiency/O were/O their/O common/O endocrinological/O features/O ./O
A/O sharp/O outbreak/O of/O influenza/O A/O occurred/O on/O the/O base/O during/O February/O that/O was/O due/O to/O an/O A/O //O Texas/O //O 1/O //O 77/O -/O like/O virus/O ,/O a/O variant/O of/O the/O A/O //O Victoria/O //O 3/O //O 75/O prototpye/O ./O
Because/O decreases/O in/O the/O disfluency/O rates/O of/O stutterers/O were/O observed/O during/O the/O presentation/O of/O all/O three/O stimulus/O words/O ,/O the/O data/O failed/O to/O support/O the/O operant/O model/O ./O
Effect/O of/O time/O and/O dose/O on/O alterations/O following/O inhalation/O of/O plutonium/O -/O 239/O dioxide/O aerosol/O in/O rat/O ./O
In/O biopsies/O CK/I -/I MB/I fraction/O of/O total/O myocardial/O CPK/I was/O 37/O %,/O the/O total/I -/I CPK/I activity/O of/O human/O skeletal/O muscles/O still/O shows/O a/O 5/O %/O fraction/O of/O CK/I -/I MB/I ./O
Value/O of/O determination/O of/O alkaline/I phosphatase/I isoenzymes/I for/O differential/O diagnosis/O of/O obstructive/O jaundice/O and/O biliary/O liver/O cirrhosis/O
A/O one/O -/O way/O analysis/O of/O variance/O ,/O performed/O separately/O for/O men/O and/O women/O for/O differences/O among/O the/O three/O phobic/O groups/O on/O field/O dependence/O ,/O showed/O significance/O (/O rho/O less/O than/O ./O 05/O )/O for/O the/O females/O ,/O with/O the/O famale/O agoraphobic/O being/O more/O field/O dependent/O than/O the/O female/O simple/O phobic/O groups/O ,/O but/O not/O for/O the/O males/O ./O
Several/O free/O 2nd/O -/O generation/O schizonts/O ,/O which/O varied/O in/O diameter/O from/O 11/O to/O 21/O ./O 6/O micrometer/O ,/O were/O found/O on/O the/O epithelial/O surface/O of/O the/O cecum/O ./O
The/O calculated/O pD2/O values/O were/O 8/O ./O 8/O for/O E/O ,/O 8/O ./O 6/O for/O DHE/O and/O 6/O ./O 6/O for/O M/O ./O
Newcastle/O disease/O virus/O surveillance/O in/O Hong/O Kong/O on/O local/O and/O imported/O poultry/O ./O
It/O was/O postulated/O that/O persistent/O challenge/O by/O M/O ./O leprae/O or/O its/O antigens/O to/O the/O IgA/I immunocytes/O of/O the/O intestinal/O epithelium/O might/O have/O induced/O tolerance/O leading/O to/O IgA/I deficiency/O and/O subsequent/O subtotal/O atrophy/O of/O the/O intestinal/O villi/O in/O the/O patients/O with/O lepromatous/O leprosy/O ./O
Treatment/O of/O hypertension/O with/O a/O combination/O of/O the/O adrenergic/I beta/I receptor/I blockader/O ,/O obsidan/O ,/O and/O the/O vasodilator/O ,/O apressin/O
Orthop/O ./O
Thyroid/O disease/O and/O pregnancy/O ./O
Residues/O removed/O from/O transcripts/O by/O splicing/O were/O identified/O ./O
To/O minimize/O reflux/O into/O the/O blind/O loop/O ,/O a/O number/O of/O technical/O steps/O are/O considered/O indispensable/O :/O 1/O )/O fluted/O section/O of/O the/O jejunal/O stump/O ;/O 2/O )/O isoperistaltic/O construction/O of/O the/O anastomosis/O and/O ,/O particularly/O ,/O 3/O )/O the/O creation/O of/O a/O single/O or/O double/O valve/O system/O upstream/O from/O the/O anastomosis/O by/O spiral/O introflexion/O of/O the/O mucosa/O using/O seroserous/O stitches/O parallel/O and/O perpendicular/O to/O the/O ileal/O lumen/O ./O
At/O this/O stage/O ,/O the/O eventual/O high/O mortality/O of/O acute/O ischemia/O is/O established/O whatever/O the/O urgency/O of/O the/O operation/O or/O the/O skill/O with/O which/O it/O is/O performed/O ./O
Pathogens/O (/O Staphylococcus/O aureus/O or/O Gram/O -/O negative/O bacilli/O )/O were/O isolated/O from/O only/O one/O member/O of/O staff/O in/O small/O numbers/O and/O irregularly/O and/O rarely/O in/O large/O numbers/O from/O patients/O ./O
The/O histochemistry/O and/O ultrastructure/O of/O calcified/O cerebellar/O deposits/O described/O by/O Tonge/O et/O al/O ./O
A/O 36/O year/O -/O old/O woman/O was/O given/O Ergotamine/O Tartrate/O 4/O ./O 5/O mg/O p/O ./O d/O ./O during/O seven/O days/O ,/O after/O an/O abortion/O (/O a/O still/O birth/O )./O
Reaction/O times/O to/O tachistoscopically/O presented/O stimuli/O in/O diabetics/O
Two/O out/O of/O five/O patients/O undergoing/O selective/O spinal/O arteriography/O developed/O transient/O neurological/O complications/O during/O the/O injection/O of/O Urografin/O 310/O M/O ./O
The/O data/O indicate/O a/O three/O -/O phase/O reaction/O after/O B1/O injection/O :/O Phase/O 1/O --/O shortly/O after/O injection/O there/O is/O a/O drop/O of/O all/O parameters/O lasting/O for/O 30/O sec/O ./O
Serum/I relaxin/I levels/O in/O prostaglandin/O E2/O induced/O abortions/O ./O
A/O --/O A/O natural/O hydrostatic/O phenomenon/O ,/O at/O the/O level/O of/O the/O ends/O of/O the/O plantar/O arcs/O ,/O diffuses/O body/O weight/O ,/O as/O PAIN/O plays/O the/O role/O of/O outsentry/O (/O fig/O .--/O 1/O )/O (/O 5/O );/O B/O --/O Plantar/O perforating/O ulceration/O (/O PPU/O )/O is/O caused/O by/O a/O combination/O of/O INSENSITIVITY/O and/O TRAUMATIS/O (/O 1/O );/O C/O --/O The/O patient/O reposing/O ,/O as/O body/O weight/O (/O traumatism/O )/O effects/O disappear/O ,/O cicatrization/O process/O can/O be/O easily/O observed/O ;/O D/O --/O PNEUMATIC/O INSOLE/O ,/O being/O elastic/O ,/O diffuses/O localized/O compression/O at/O the/O ends/O of/O the/O plantar/O arcs/O ,/O reduces/O attrition/O ,/O makes/O easier/O blood/O circulation/O ,/O as/O well/O as/O cure/O and/O prophylaxis/O of/O PPU/O (/O fig/O .--/O 6/O )/O (/O 3/O )./O
Effect/O of/O indoramin/O in/O small/O doses/O on/O the/O central/O vasomotor/O loci/O has/O been/O studied/O in/O chloralose/O anesthetized/O cats/O by/O localizing/O it/O to/O the/O central/O sites/O ./O
As/O expected/O ,/O the/O heparin/O did/O produce/O increased/O recalcification/O times/O and/O the/O development/O of/O occasional/O subcutaneous/O hematomas/O ./O
Contingency/O contracting/O between/O clients/O and/O their/O parents/O //O caregivers/O was/O used/O to/O specify/O consequences/O for/O daily/O self/O -/O monitoring/O ,/O reduced/O caloric/O intake/O ,/O weight/O loss/O ,/O and/O exercise/O ./O
Dietetics/O of/O childhood/O -/O and/O juvenile/O diabetes/O
The/O results/O of/O a/O quantitative/O study/O of/O vasculosyncytial/O membranes/O in/O 123/O placentas/O are/O presented/O ./O
The/O micromethod/O uses/O microcuvettes/O and/O substitutes/O ferrozine/O for/O the/O bathophenanthroline/O chromogen/O of/O the/O ICSH/O ./O
Platelet/O serotonin/O (/O 5/O -/O HT/O )/O and/O 5/I -/I HT/I releasing/I factor/I in/O plasma/O of/O migrainous/O patients/O ./O
The/O overall/O incidence/O of/O SIDS/O was/O 1/O ./O 43/O per/O 1/O ,/O 000/O live/O births/O ./O
The/O vigilance/O task/O and/O the/O measurement/O of/O attentional/O deficits/O ./O
The/O December/O armed/O revolt/O in/O Moscow/O and/O the/O paramedical/O personnel/O
Significant/O increases/O in/O mean/O serum/O E2/O concentration/O (/O 100/O to/O 150/O pg/O //O ml/O )/O were/O noted/O at/O 6/O and/O 8/O hours/O after/O administration/O on/O day/O 1/O and/O at/O 8/O hours/O on/O day/O 4/O ./O
The/O motor/O unit/O viewed/O from/O above/O ./O
Avian/O reproductive/O system/O :/O daily/O variations/O in/O responses/O to/O hormones/O ./O
Biological/O properties/O of/O sumithion/O ./O
Serological/O studies/O of/O antibodies/O to/O Epstein/O -/O Barr/O virus/O in/O infectious/O mononucleosis/O
Carcinoembryonic/I antigen/I (/O CEA/I )/O procedures/O and/O clinical/O evaluation/O ./O
We/O remain/O convinced/O that/O antilymphocyte/I globulin/I (/O ALG/I )/O is/O a/O potent/O immunosuppressive/O agent/O in/O humans/O ./O
On/O the/O basis/O of/O a/O global/O assessment/O patients/O showed/O a/O highly/O significant/O preference/O for/O imipramine/O compared/O with/O placebo/O as/O adjunctive/O therapy/O ./O
39/O -/O 47/O ./O
Patients/O were/O subclassified/O into/O age/O -/O matched/O groups/O of/O primary/O untreated/O cancer/O (/O 21/O ),/O recurrent/O cancer/O (/O 18/O ),/O and/O "/O cured/O "/O patients/O who/O had/O been/O free/O of/O disease/O for/O at/O least/O 9/O months/O (/O 16/O )./O
Absorption/O varied/O between/O 65/O and/O 95/O per/O cent/O ,/O with/O a/O mean/O absorption/O of/O 80/O per/O cent/O ,/O in/O both/O pregnant/O and/O non/O -/O pregnant/O subjects/O ./O
Bacteriostatic/O and/O bacteriacidal/O activity/O of/O hydroxy/O -/O 9/O ellipticine/O in/O vitro/O
Advances/O in/O the/O management/O of/O gynecologic/O cancer/O --/O radiation/O therapy/O ./O
The/O clinico/O -/O pathological/O data/O from/O a/O patient/O with/O irreversible/O post/O -/O partum/O renal/O failure/O (/O IPRF/O )/O are/O presented/O ./O
Personal/O satisfaction/O in/O nursing/O :/O an/O encounter/O with/O extremely/O hostile/O patients/O
Dialyzable/O transfer/I factor/I ./O
19/O -/O 32/O ./O
Rheumatoid/I factor/I and/O antinuclear/O antibody/O tests/O were/O frequently/O positive/O ,/O and/O reactions/O to/O gold/O therapy/O were/O more/O frequent/O than/O in/O other/O rheumatoid/O populations/O ./O
The/O effect/O of/O hydrostatic/O pressure/O on/O the/O swimming/O activity/O of/O three/O hyponeustonic/O crustacea/O ,/O Anomalocera/O patersoni/O ,/O Pontella/O mediterranea/O ,/O Labidocera/O wollastoni/O
This/O report/O presents/O an/O analysis/O of/O the/O vocal/O repertoire/O of/O howler/O monkeys/O (/O Alouatta/O palliata/O )/O observed/O during/O a/O field/O study/O in/O southwestern/O Panama/O ./O
Up/O to/O now/O the/O number/O of/O patients/O examined/O is/O about/O 300/O ,/O additionally/O 6/O persons/O who/O underwent/O binephrectomy/O ./O
Deflunia/O was/O well/O tolerated/O by/O 25/O patients/O ,/O very/O well/O tolerated/O by/O 2/O ./O
III/O ./O
A/O new/O instrument/O has/O been/O designed/O for/O freeze/O -/O fracturing/O of/O biological/O material/O in/O ultra/O high/O vacuum/O ./O
Pancreatic/O and/O biliary/O secretion/O and/O gastric/O emptying/O rates/O of/O a/O liquid/O test/O meal/O (/O LTM/O )/O were/O determined/O in/O normal/O persons/O ,/O in/O patients/O with/O subtotal/O gastrectomy/O with/O gastroduodenostomy/O (/O STG/O -/O BI/O )/O or/O with/O gastrojejunostomy/O (/O STG/O -/O BII/O ),/O and/O in/O patients/O with/O truncal/O vagotomy/O and/O pyloroplasty/O (/O V/O &/O P/O )./O
Abnormal/O calcium/O metabolism/O in/O normocalcaemic/O sarcoidosis/O ./O
Also/O ,/O except/O in/O one/O patient/O who/O developed/O gallstones/O following/O institution/O of/O colestipol/O ,/O saturation/O of/O gallbladder/O bile/O with/O cholesterol/O was/O not/O markedly/O increased/O by/O this/O drug/O alone/O ./O
A/O five/O -/O phase/O experiment/O was/O designed/O to/O investigate/O (/O a/O )/O whether/O contingent/O music/O -/O listening/O would/O act/O as/O a/O reinforcer/O to/O increase/O arithmetic/O performance/O of/O EMR/O children/O and/O (/O b/O )/O whether/O this/O contingent/O reinforcement/O would/O affect/O preference/O for/O that/O reinforcer/O ./O
The/O responsiveness/O of/O visual/O cortex/O (/O VC/O )/O and/O superior/O colliculus/O (/O SC/O )/O was/O simultaneously/O compared/O following/O conditioning/O "/O ON/O "/O or/O "/O OFF/O "/O stimulation/O ,/O in/O the/O rabbit/O ./O
A/O diagnosis/O of/O MS/O was/O made/O based/O on/O subtle/O neurologic/O signs/O ,/O spinal/O fluid/O gamma/I globulin/I elevations/O ,/O and/O abnormalities/O in/O neuropsychological/O testing/O ./O
If/O ,/O however/O ,/O the/O mean/O temperature/O rise/O was/O higher/O (/O 0/O ./O 57/O degrees/O C/O or/O 0/O ./O 69/O degrees/O C/O ),/O such/O a/O selection/O practically/O resulted/O in/O the/O disappearance/O of/O '/O passable/O '/O qualifications/O in/O the/O triplet/O groups/O and/O a/O great/O predominance/O of/O '/O to/O be/O rejected/O '/O qualifications/O in/O the/O large/O groups/O ./O
The/O elevated/O Viso/O V/O in/O the/O RDS/O group/O suggests/O an/O increase/O in/O small/O airway/O resistance/O secondary/O to/O the/O disease/O or/O to/O its/O therapy/O ./O
The/O psychological/O tests/O consisted/O of/O a/O free/O -/O recall/O task/O ,/O a/O test/O for/O visuomotor/O coordination/O and/O a/O recognition/O task/O ./O
Selective/O bronchial/O intubation/O in/O the/O management/O of/O unilateral/O pulmonary/O interstitial/O emphysema/O ./O
The/O background/O processes/O depending/O on/O the/O etiological/O factor/O and/O the/O character/O of/O lesion/O of/O the/O epithelium/O are/O divided/O into/O dyshormonal/O ,/O inflammatory/O ,/O and/O posttraumatic/O ./O
The/O sense/O of/O self/O ./O
Eleven/O strains/O of/O Fusarium/O poae/O and/O F/O ./O sporotrichioides/O from/O the/O U/O ./O S/O ./O S/O ./O R/O ./O and/O 7/O strains/O of/O these/O species/O and/O one/O of/O F/O ./O sporotrichioides/O var/O ./O tricinctum/O from/O U/O ./O S/O ./O A/O ./O and/O France/O have/O been/O compared/O as/O to/O their/O capacity/O to/O yield/O T/I -/I 2/I toxin/I ./O
Current/O diagnostic/O uses/O of/O computerized/O tomography/O in/O clinical/O medicine/O ./O
A/O follow/O -/O up/O study/O of/O 22/O patients/O with/O Ebstein/O '/O s/O anomaly/O has/O been/O performed/O ./O
Deaths/O stopped/O 11/O hours/O after/O copper/O concentrations/O decreased/O below/O 0/O ./O 2/O ppm/O and/O signs/O of/O distress/O stopped/O in/O surviving/O pinfish/O by/O approximately/O 6/O hours/O after/O the/O last/O death/O ./O
Recurrence/O of/O bladder/O tumors/O among/O the/O original/O 9/O cases/O has/O occurred/O only/O among/O the/O 5/O whose/O properdin/I levels/O remained/O below/O the/O median/O ./O
Adaptation/O of/O taurocholate/O transport/O maximum/O to/O increased/O secretory/O load/O in/O the/O rat/O ./O
Dangers/O in/O use/O of/O live/O -/O virus/O vaccines/O ./O
Treatment/O with/O heparin/O ,/O plasminogen/I activators/O and/O fibrinogenolytic/O agents/O was/O disappointing/O although/O renal/O function/O has/O stabilized/O in/O one/O patient/O on/O long/O term/O oral/O anticoagulant/O therapy/O ./O
In/O diethyl/O ether/O solution/O the/O main/O peak/O is/O that/O of/O 2/O -/O benzylidenamio/O -/O 1/O -/O phenylpropane/O ,/O which/O has/O a/O retention/O time/O of/O 23/O ,/O 2/O minutes/O under/O the/O condition/O delineated/O ./O
Amikacin/O was/O used/O in/O the/O treatment/O of/O 56/O serious/O gram/O -/O negative/O infections/O in/O 54/O patients/O of/O whom/O 47/O survived/O ./O
The/O data/O normally/O available/O are/O insufficient/O and/O take/O no/O account/O of/O the/O direction/O of/O recirculation/O ,/O which/O may/O be/O a/O determining/O factor/O ./O
During/O activity/O III/O ,/O one/O patient/O developed/O angina/O ./O
Estimation/O of/O L/O -/O alanine/O in/O serum/O or/O plasma/O using/O the/O LKB/O reaction/O rate/O analyser/O ./O
The/O acids/O were/O obtained/O by/O hydrolysis/O of/O the/O corresponding/O esters/O ,/O and/O their/O anti/O -/O inflammatory/O activity/O was/O tested/O ./O
Unrecognized/O amnionitis/O and/O prematurity/O :/O a/O preliminary/O report/O ./O
Evaluation/O of/O the/O new/O Gravigard/O IUCD/O inserter/O ./O
Bacterial/O meningitis/O secondary/O to/O abscess/O of/O the/O nasal/O septum/O ./O
Serum/I amylase/I became/O markedly/O elevated/O (/O 2/O ,/O 624/O CU/O //O 100/O ml/O ),/O as/O did/O the/O serum/O FFA/O (/O 29/O ./O 19/O mEq/O //O liter/O )./O
In/O the/O control/O preparation/O before/O weight/O was/O allowed/O to/O increase/O ,/O isogravimetric/O capillary/O pressure/O (/O Pci/O )/O averaged/O 8/O mmHg/O lower/O than/O colloid/O osmotic/O pressure/O of/O the/O plasma/O (/O IIp/O )./O
Infants/O who/O died/O in/O the/O first/O 12/O hours/O from/O '/O IVH/O only/O '/O had/O suffered/O severe/O birth/O asphyxia/O but/O in/O those/O who/O died/O later/O the/O main/O symptom/O was/O recurrent/O apnoea/O ./O
The/O morphological/O effects/O of/O two/O snake/O venoms/O ,/O N/O ./O naja/O and/O A/O ./O piscivorus/O ,/O and/O of/O the/O Direct/I Lytic/I Factor/I and/O Phospholipase/I -/I A/I ,/O compounds/O purified/O from/O N/O ./O naja/O crude/O venom/O ,/O were/O investigated/O on/O lung/O and/O cremaster/O vessels/O of/O rats/O ./O
Since/O GAGs/O are/O the/O components/O of/O cartilage/O matrix/O ,/O the/O depletion/O of/O which/O is/O associated/O with/O osteoarthrosis/O ,/O a/O method/O for/O measuring/O sulphated/O GAG/O synthesis/O in/O culture/O has/O been/O investigated/O ./O
The/O length/O scales/O of/O the/O turbulence/O were/O also/O estimated/O :/O at/O a/O Reynolds/O number/O near/O 4/O ,/O 000/O the/O macroscale/O is/O about/O 1/O ./O 25/O mm/O ,/O the/O Taylor/O microscale/O is/O about/O 0/O ./O 85/O mm/O ,/O and/O the/O Kolmogoroff/O scale/O is/O near/O 0/O ./O 075/O mm/O ./O
Well/O -/O visualised/O arteriograms/O of/O the/O limbs/O can/O be/O obtained/O by/O xeroradiography/O after/O rapid/O manual/O injection/O of/O contrast/O -/O medium/O into/O an/O arm/O vein/O ,/O as/O demonstrated/O in/O 28/O patients/O ./O
No/O hypotension/O was/O noted/O in/O patients/O with/O toxemia/O and/O only/O 2/O ran/O a/O fever/O above/O 37/O ./O 5/O degrees/O C/O ./O
The/O sera/O and/O nasal/O secretions/O of/O 142/O patients/O ,/O who/O were/O positive/O in/O HD/O or/O mites/O skin/O test/O ,/O were/O subjected/O to/O a/O radioallergosorbent/O test/O (/O RAST/O )/O for/O estimating/O the/O specific/O IgE/I antibody/I activity/O to/O mites/O ./O
Wherever/O the/O site/O of/O the/O conditioning/O stimulation/O ,/O these/O modifications/O disappeared/O after/O ischaemia/O of/O the/O leg/O ./O
Diallylnitrosamine/O (/O DAN/O ),/O one/O of/O the/O few/O nitrosamines/O tested/O thus/O far/O that/O has/O not/O induced/O neoplasms/O in/O rats/O ,/O caused/O a/O high/O incidence/O of/O respiratory/O tract/O tumors/O in/O Syrian/O golden/O hamsters/O treated/O sc/O with/O single/O or/O weekly/O doses/O of/O the/O compound/O ./O
Near/O term/O ,/O under/O experimental/O conditions/O ,/O maternal/O and/O fetal/O blood/O gases/O ,/O pH/O ,/O uterine/O and/O umbilical/O blood/O flows/O were/O measured/O or/O calculated/O ./O
Haemodynamic/O responses/O to/O antagonism/O of/O bocurarine/O block/O with/O atropine/O -/O neostigmine/O mixture/O in/O children/O ./O
The/O mechanism/O by/O which/O large/O molecules/O ,/O such/O as/O the/O diphosphonate/O 99mTc/O -/O labeled/O EHDP/O or/O 99mTc/O -/O labeled/O pyrophosphate/O ,/O pass/O through/O capillaries/O in/O bone/O is/O by/O passive/O diffusion/O ./O
Twenty/O -/O nine/O days/O after/O injection/O of/O 5/O ./O 8/O mCi/O of/O Tc/O -/O 99m/O ,/O which/O gives/O 28/O rads/O to/O the/O testis/O ,/O the/O number/O of/O sperm/O hads/O decreased/O to/O 70/O %/O of/O control/O ./O
Self/O -/O emasculation/O is/O the/O end/O result/O of/O an/O unusual/O psychiatric/O disorder/O ,/O which/O initially/O requires/O surgical/O treatment/O ./O
Possibility/O of/O a/O TSH/I -/O Screening/O method/O for/O detection/O of/O hypothyroidism/O in/O the/O newborn/O
Thus/O analysis/O indicated/O no/O reliable/O evidence/O that/O conscious/O presleep/O suggestions/O become/O incorporated/O into/O dream/O content/O ./O
The/O prevalence/O of/O hepatitis/I B/I surface/I antigen/I (/O HBsAg/I )/O and/O anti/I -/I HBs/I was/O determined/O by/O a/O sensitive/O double/O -/O antibody/O radio/O -/O immunoassay/O technique/O in/O a/O series/O of/O patients/O with/O chronic/O liver/O diseases/O ./O
It/O was/O concluded/O that/O patients/O with/O acute/O respiratory/O failure/O requiring/O artificial/O ventilation/O have/O two/O componenents/O of/O the/O pulmonary/O shunt/O ,/O one/O parallel/O with/O and/O the/O other/O inversely/O related/O with/O the/O PAO2/O ./O
Decreased/O cardiac/O glycogen/O following/O phenformin/O injection/O in/O hyperglycemic/O ,/O hyperinsulinemic/O anaesthetized/O rats/O ./O
Biological/O evaluation/O of/O mibolerone/O in/O the/O female/O Beagle/O ./O
Levels/O of/O both/O PGF/O and/O PGFM/O were/O significantly/O higher/O during/O early/O spontaneous/O labour/O ,/O at/O a/O cervical/O dilatation/O of/O less/O than/O 4/O cm/O ,/O than/O before/O the/O onset/O of/O labour/O ./O
The/O most/O common/O cause/O of/O renal/O deterioration/O in/O the/O spinal/O cord/O injured/O patient/O is/O irreversible/O vesicoureteral/O reflux/O ./O
Propranolol/O (/O Inderal/O )/O administered/O in/O a/O dose/O which/O blocks/O the/O beta/O -/O adrenergic/O apparatus/O of/O the/O heart/O prevents/O the/O development/O of/O the/O positive/O inotropic/O effect/O of/O therapeutic/O doses/O of/O strophanthin/O K/O on/O a/O hypodynamic/O left/O ventricular/O myocardium/O ./O
Recent/O studies/O have/O shown/O the/O rat/O larynx/O to/O be/O an/O important/O organ/O in/O the/O evaluation/O of/O irritancy/O of/O inhaled/O materials/O ./O
Scanning/O electron/O microscopic/O investigations/O on/O the/O formation/O of/O Reissner/O '/O s/O fiber/O in/O Rattus/O rattus/O
Feeding/O behavior/O ,/O circannual/O body/O weight/O and/O hibernation/O rhythms/O in/O European/O hamsters/O lesioned/O in/O the/O noradrenergic/O ascending/O bundles/O
Role/O of/O the/O infectious/O -/O disease/O specialist/O of/O a/O polyclinic/O in/O reducing/O the/O incidence/O of/O communicable/O diseases/O
These/O observed/O drug/O interactions/O ,/O plus/O the/O known/O effect/O of/O probenecid/O to/O block/O secretion/O of/O PZA/O ,/O have/O to/O be/O considered/O in/O evaluating/O the/O effect/O of/O the/O two/O drugs/O given/O together/O ,/O compared/O to/O the/O effect/O of/O each/O drug/O given/O separately/O ./O
Circulatory/O arrest/O in/O the/O operating/O room/O ./O
At/O a/O systolic/O blood/O pressure/O (/O BP/O )/O of/O 60/O mmHg/O ,/O C02/O responsiveness/O was/O abolished/O ,/O but/O was/O maintained/O at/O higher/O levels/O of/O BP/O ./O
Iodine/O -/O 123/O was/O satisfactorily/O imaged/O only/O with/O the/O MEC/O and/O pinhole/O collimators/O ,/O which/O in/O turn/O yielded/O MTF/O values/O comparable/O to/O those/O measured/O for/O 99mTc/O ./O
Petrous/O meningioma/O en/O plaque/O presenting/O as/O a/O right/O middle/O ear/O tumor/O ./O
The/O difficulties/O to/O analyse/O prostaglandins/O (/O PG/O )/O by/O gas/O -/O liquid/O chromatography/O are/O mainly/O due/O to/O the/O lack/O of/O sensitivity/O of/O the/O gas/O -/O chromatograph/O itself/O (/O higher/O than/O 200/O ng/O )/O and/O to/O the/O poor/O resolution/O of/O the/O packed/O columns/O ./O
On/O cessation/O of/O steroid/O therapy/O the/O patient/O was/O noted/O to/O have/O radiologic/O manifestations/O of/O hypertrophic/O osteoarthropathy/O (/O HOA/O )/O as/O well/O as/O clinical/O and/O laboratory/O features/O of/O rheumatoid/O arthritis/O (/O RA/O )./O
The/O effect/O of/O food/O on/O procainamide/O absorption/O ./O
After/O giving/O a/O survey/O on/O the/O situation/O of/O antibiotic/O resistance/O in/O the/O region/O of/O Northern/O Bavaria/O during/O 1973/O //O 74/O and/O comparing/O the/O activity/O of/O a/O sulfamethoxazole/O (/O SMZ/O )/O trimethoprim/O (/O TMP/O )/O combination/O to/O other/O commonly/O used/O antibiotics/O and/O chemotherapeutic/O agents/O ,/O the/O results/O of/O tests/O with/O the/O new/O combination/O of/O N1/O -(/O 4/O ,/O 5/O -/O dimethyl/O -/O 2/O -/O oxazolyl/O )-/O sulfanilamide/O )/O (/O sulfamoxole/O )/O and/O 2/O ,/O 4/O -/O diamino/O -/O 5/O -(/O 3/O ,/O 4/O ,/O 5/O -/O trimethoxy/O -/O benzyl/O )-/O pyrimidine/O (/O trimethoprim/O )/O at/O a/O ratio/O of/O 5/O :/O 1/O (/O CN/O 3123/O ;/O Nevin/O ,/O Supristol/O )/O are/O compared/O to/O those/O of/O tests/O with/O TMP/O //O SMZ/O ./O
RESULTS/O :/O Total/O IgE/I levels/O showed/O a/O tendency/O to/O diminish/O ./O
Does/O afferent/O loop/O syndrome/O exist/O ?]/O It/O is/O the/O author/O '/O s/O opinion/O that/O diagnosis/O of/O the/O "/O adducent/O loop/O syndrome/O "/O is/O unlikely/O to/O be/O correct/O in/O patients/O subjected/O to/O Billroth/O -/O II/O gastrectomy/O ./O
Letter/O :/O Is/O actinic/O (/O solar/O )/O damage/O the/O provoking/O cause/O of/O '/O post/O -/O inflammatory/O elastolysis/O and/O cutis/O laxa/O (/O PECL/O )'?/O
These/O data/O suggest/O that/O spontaneous/O recovery/O of/O central/O respiratory/O function/O after/O intoxication/O with/O Soman/O or/O Sarin/O may/O not/O be/O related/O to/O the/O return/O of/O AChE/I activity/O ./O
Batch/O cultures/O of/O S/O ./O mutans/O serotype/O a/O demonstrated/O no/O growth/O on/O MSB/O agar/O ./O
Also/O ,/O samples/O of/O serum/O were/O absorbed/O with/O the/O various/O solid/O -/O phase/O allergens/O and/O the/O reactivity/O of/O the/O remaining/O IgE/I antibodies/I was/O determined/O ./O
Crisis/O of/O the/O therapeutic/O community/O in/O Great/O Britain/O
Pregnant/O women/O at/O term/O had/O the/O lowest/O levels/O of/O antithrombin/I III/I ./O
Hematology/O problem/O of/O the/O month/O :/O band/O or/O seg/O ?/O
It/O is/O possible/O that/O cyclic/O variations/O in/O heme/O turnover/O are/O related/O to/O changes/O in/O erythrocyte/O characteristics/O during/O the/O progesterone/O phase/O ./O
Haemodilution/O in/O cardiopulmonary/O bypass/O using/O a/O gelatine/O derivative/O for/O priming/O ./O
Extramedullary/O plasmacytoma/O of/O the/O parotid/O gland/O
I/O ./O
The/O recovered/O calves/O were/O tested/O for/O immunity/O to/O homologous/O severe/O challenge/O ,/O 50/O or/O 73/O days/O after/O the/O first/O infection/O ./O
The/O performance/O of/O three/O commonly/O used/O chemical/O cartridge/O respirators/O for/O SO2/O was/O measured/O under/O working/O conditions/O in/O a/O copper/O smelter/O ./O
The/O neuroleptic/O -/O induced/O increase/O in/O central/O DA/O turnover/O (/O an/O indicator/O for/O the/O degree/O of/O DA/I receptor/I blocking/O )/O was/O found/O to/O be/O positively/O correlated/O with/O the/O therapeutic/O effect/O of/O neuroleptics/O and/O the/O development/O of/O hypokinetic/O -/O rigid/O symptoms/O ./O
Rainbow/O trout/O were/O obtained/O from/O a/O commercial/O trout/O farm/O ,/O kept/O in/O running/O water/O and/O feeding/O in/O experimental/O pellets/O for/O 4/O to/O 8/O weeks/O ./O
Stimulation/O of/O macrophage/O function/O by/O killed/O Bordetella/O pertussis/O cells/O did/O not/O show/O any/O beneficial/O effect/O as/O an/O increased/O susceptibility/O became/O apparent/O ./O
Primary/O amenorrhoea/O in/O a/O phenotypically/O female/O individual/O with/O a/O karyotype/O 46/O ,/O xy/O and/O bilateral/O gonadoblastoma/O
Toward/O absolute/O methods/O in/O clinical/O chemistry/O :/O application/O of/O mass/O fragmentography/O to/O high/O -/O accuracy/O analyses/O ./O
Application/O of/O the/O 2/O -/O deoxy/O -/O D/O -/O glucose/O method/O to/O the/O coupling/O of/O cerebral/O metabolism/O and/O blood/O flow/O ./O
Serum/O gastrin/I levels/O did/O not/O change/O in/O either/O group/O ;/O however/O ,/O background/O serum/O gastrin/I concentrations/O were/O significantly/O greater/O for/O V/O &/O P/O patients/O than/O V/O &/O A/O patients/O throughout/O the/O study/O ./O
Efferent/O projections/O of/O the/O ventral/O portion/O of/O the/O putamen/O to/O the/O frontal/O ,/O parietal/O and/O temporal/O regions/O of/O the/O cat/O cerebral/O cortex/O
Preflight/O ,/O inflight/O ,/O and/O postflight/O exercise/O response/O tests/O were/O conducted/O on/O the/O astronauts/O of/O the/O second/O Skylab/O mission/O (/O Skylab/O 3/O )/O as/O part/O of/O an/O evaluation/O of/O physiological/O adaptation/O to/O long/O -/O term/O weightlessness/O ./O
Mean/O corpuscular/I hemoglobin/I concentrations/O remained/O normal/O for/O 48/O h/O and/O then/O decreased/O in/O both/O groups/O ,/O the/O CO2/O group/O showing/O the/O larger/O decrease/O ./O
All/O Cu/O values/O obtained/O from/O the/O organs/O investigated/O had/O reached/O a/O saturation/O level/O at/O 8/O mug/O Cu/O //O g/O diet/O with/O the/O exception/O of/O the/O values/O for/O body/O Cu/O found/O in/O the/O dams/O that/O were/O killed/O on/O the/O day/O of/O delivery/O ./O
The/O effect/O of/O calcitonin/I ,/O a/O large/O amount/O of/O calcium/O given/O orally/O ,/O pentagastrin/O and/O glucagon/I on/O plasma/O 47Ca/O radioactivity/O curves/O in/O subjects/O pretreated/O with/O 47Ca/O was/O examined/O ./O
State/O of/O the/O body/O in/O disorders/O of/O diurnal/O physiological/O rhythms/O and/O long/O -/O term/O hypokinesia/O
Oxygen/O tension/O of/O the/O small/O lymph/O vessels/O (/O PLO2/O )/O of/O the/O rabbit/O hind/O limb/O was/O measured/O with/O both/O a/O flow/O -/O through/O micro/O chamber/O and/O a/O polarographic/O catheter/O -/O tip/O oxygen/O electrode/O to/O obtain/O experimental/O data/O on/O the/O source/O of/O oxygen/O in/O the/O lymph/O ./O
The/O response/O of/O the/O plasma/I fibrinogen/I level/O to/O the/O subucutaneous/O injection/O of/O turpentine/O and/O to/O the/O intravenous/O injection/O of/O endotoxin/O was/O measured/O in/O normal/O rabbits/O and/O in/O rabbits/O made/O granulocytopenic/O and/O thrombocytopenic/O with/O busulfan/O ./O
Constantly/O rectilinear/O pressure/O curves/O without/O uterine/O activities/O are/O interpreted/O as/O characteristic/O tocographic/O criteria/O of/O an/O advanced/O ectopic/O gravidity/O ./O
Since/O myoglobin/I is/O co/O -/O extracted/O with/O the/O hemoglobin/I ,/O the/O 2/O heme/O pigments/O are/O separated/O in/O one/O portion/O of/O the/O extract/O by/O precipitating/O the/O hemoglobin/I in/O an/O 85/O %/O (/O NH4/O )/O 2SO4/O solution/O ./O
Considering/O these/O sources/O of/O error/O some/O of/O the/O variability/O in/O the/O present/O investigation/O might/O be/O avoided/O by/O systematic/O instructions/O ./O
E/O 50/O ,/O 843/O (/O 1994/O )]./O
Six/O patients/O with/O the/O diagnosis/O of/O acute/O mania/O were/O treated/O with/O high/O doses/O of/O the/O beta/O -/O adrenergic/O blocking/O agent/O propranolol/O ./O
Effect/O of/O trauma/O on/O plasma/I glucagon/I and/O insulin/I concentrations/O in/O sheep/O ./O
With/O the/O help/O of/O a/O nomogram/O one/O can/O read/O off/O the/O refraction/O ,/O when/O axis/O length/O and/O corneal/O curvature/O are/O known/O ./O
This/O up/O -/O grading/O of/O the/O final/O score/O by/O the/O CA/O component/O is/O greater/O (/O 3/O -/O 8/O %)/O in/O the/O less/O able/O students/O with/O scores/O below/O the/O mean/O level/O ./O
Compared/O to/O controls/O ,/O both/O UB/O and/O OCS/O rats/O showed/O a/O small/O but/O significant/O post/O -/O operative/O reduction/O in/O the/O nocturnality/O of/O drinking/O ./O
Effect/O of/O indomethacin/O on/O coronary/O circulation/O :/O effect/O on/O ECG/O tracing/O
Dual/O innervation/O of/O fast/O fibers/O in/O trunk/O muscles/O of/O lamprey/O larvae/O
The/O feed/O consumed/O which/O was/O lowered/O by/O 25/O %/O initially/O ,/O did/O not/O alter/O later/O ./O
Certain/O characteristics/O of/O eye/O changes/O in/O patients/O with/O pheochromocytoma/O including/O Sipple/O '/O s/O syndrome/O
The/O color/O -/O word/O interference/O effect/O previously/O reported/O with/O normal/O populations/O when/O given/O the/O Stroop/O test/O was/O demonstrated/O for/O this/O retarded/O sample/O using/O a/O special/O format/O ./O
It/O was/O found/O that/O under/O the/O selected/O conditions/O a/O linear/O dependence/O exists/O between/O the/O betaI/O %/O value/O and/O lgC/O within/O the/O range/O of/O 0/O ./O 5/O --/O 10/O mug/O ruscogenin/O ./O
The/O influence/O of/O adrenergic/O nerves/O of/O the/O response/O of/O blood/O vessels/O in/O the/O rabbit/O ear/O to/O 2/I --/I phenylalanine/I -/I 8/I -/I lysine/I vasopressin/I (/O Octapressin/I )./O
Potscoital/O test/O
I/O ./O
When/O a/O tumour/O is/O present/O nipple/O discharge/O is/O of/O little/O importance/O for/O the/O diagnosis/O and/O treatment/O ./O
Studies/O of/O biochemical/O and/O morphological/O changes/O (/O between/O normal/O and/O treated/O animals/O )/O show/O that/O chrysotile/O induces/O an/O increase/O in/O the/O lung/O free/O cell/O population/O and/O pulmonary/O surfactant/O levels/O ./O
Infrared/O measurements/O of/O temperature/O changes/O and/O estimates/O of/O the/O heating/O produced/O at/O the/O mical/O ./O
Who/O says/O '/O National/O Health/O Dis/O -/O service/O './O
Is/O criticism/O of/O patient/O care/O justified/O and/O does/O it/O have/O educational/O value/O ?/O Patients/O '/O criticism/O contributes/O to/O improved/O patient/O care/O
Critique/O of/O "/O Interactive/O Effects/O of/O Test/O Anxiety/O and/O Credit/O //O No/O Credit/O or/O A/O -/O F/O Grade/O Condition/O upon/O Short/O -/O term/O and/O Long/O -/O term/O Recall/O of/O Course/O Information/O ./O
These/O studies/O have/O shown/O that/O the/O majority/O of/O tested/O staphylococci/O were/O resistant/O to/O penicillin/O G/O ,/O erythromycin/O ,/O and/O produced/O beta/I -/I lactamase/I ./O
Since/O 1968/O ,/O a/O steep/O decrease/O in/O the/O number/O of/O strains/O resistant/O to/O three/O or/O more/O antibiotics/O (/O multiple/O -/O resistant/O )/O and/O in/O strains/O of/O the/O 83A/O complex/O was/O noticed/O ./O
Improvement/O of/O nursing/O instruction/O to/O be/O given/O at/O the/O time/O of/O discharge/O from/O the/O ward/O for/O premature/O infants/O
No/O difference/O in/O the/O clinical/O acceptability/O could/O be/O ascertained/O between/O the/O two/O groups/O ./O
After/O 90/O d/O a/O subsurface/O ,/O radiolucent/O caries/O -/O like/O lesion/O was/O observed/O in/O two/O specimens/O only/O ./O
The/O contraceptive/O pattern/O of/O 157/O women/O was/O analysed/O and/O 13/O ./O 8/O percent/O were/O using/O inefficient/O methods/O ./O
Plethysmographic/O technique/O and/O indirect/O blood/O pressure/O recordings/O were/O used/O ./O
I/O ./O
The/O second/O and/O third/O responded/O similarly/O to/O either/O a/O combined/O cyclophosphamide/O +/O antilymphocyte/I globulin/I (/O ALG/I )/O treatment/O or/O to/O ALG/I administration/O preceded/O by/O a/O small/O dosage/O of/O cyclophosphamide/O ,/O which/O had/O proved/O ineffective/O when/O administered/O alone/O ./O
Evidence/O is/O presented/O that/O Leber/O '/O s/O military/O aneurysm/O retinitis/O is/O not/O a/O separate/O entity/O but/O a/O special/O form/O of/O Coats/O '/O disease/O ./O
Fibrin/I cloaking/O along/O the/O catheter/O was/O found/O in/O 20/O patients/O studied/O by/O pull/O -/O out/O arteriography/O and/O was/O unassociated/O with/O clinical/O symptoms/O ./O
The/O influence/O of/O a/O mobile/O pupil/O on/O the/O response/O in/O the/O DC/O -/O ERG/O is/O demonstrated/O ./O
A/O newly/O synthesized/O anti/O -/O inflammatory/O agent/O ,/O Y/O -/O 8004/O demonstrated/O a/O greater/O inhibition/O than/O did/O indomethacin/O (/O IM/O )./O on/O inflammatory/O response/O such/O as/O ultraviolet/O erythema/O in/O guinea/O pigs/O ,/O carrageenin/O edema/O ,/O evans/O blue/O and/O carrageenin/O -/O induced/O pleuritis/O and/O acetic/O acid/O -/O induced/O peritonitis/O in/O rats/O ./O
As/O stands/O shifted/O in/O dominance/O from/O pine/O to/O fir/O with/O age/O ,/O subalpine/O fir/O appeared/O to/O maintain/O gradually/O increasing/O rates/O of/O whole/O -/O forest/O productivity/O until/O stands/O were/O approximately/O 400/O years/O old/O ./O
Alpha/I -/I 1/I antitrypsin/I and/O Indian/O childhood/O cirrhosis/O ./O
Lymphocyte/O subpopulations/O ,/O serum/I IgE/I and/O total/O eosinophil/O counts/O in/O patients/O with/O bronchial/O asthma/O ./O
A/O range/O of/O normal/O ventricular/O measurements/O for/O the/O EMI/O scan/O is/O suggested/O ./O
A/O comparison/O of/O physical/O and/O cytogenetic/O estimates/O of/O radiation/O dose/O in/O patients/O treated/O with/O iodine/O -/O 131/O for/O thyroid/O carcinoma/O ./O
Technique/O for/O obtaining/O refined/O ceramics/O with/O dense/O mass/O
Mean/O total/O lung/O capacity/O ,/O functional/O residual/O capacity/O ,/O and/O residual/O volume/O increased/O significantly/O ,/O and/O the/O mean/O closing/O volume/O ,/O the/O lung/O volume/O above/O residual/O volume/O at/O which/O phase/O IV/O begins/O ,/O decreased/O significantly/O with/O 11/O cm/O H20/O continuous/O positive/O airway/O pressure/O ;/O differences/O at/O 5/O cm/O H20/O were/O not/O significant/O ./O
Current/O status/O of/O zinc/O deficiency/O in/O the/O pathogenesis/O of/O neurological/O ,/O dermatological/O and/O musculoskeletal/O disorders/O ./O
Calcium/O and/O phosphorus/O metabolism/O in/O chronic/O uremia/O ./O
Modern/O studies/O ,/O conducted/O with/O Delta/O -/O 9/O -/O THC/O ,/O in/O healthy/O voluntaries/O ,/O again/O suggest/O the/O comparison/O or/O even/O the/O identity/O of/O the/O modifications/O caused/O by/O cannabis/O with/O sleep/O and/O dream/O ./O
The/O correcting/O action/O of/O tropatepine/O hydrochloride/O upon/O the/O extrapyramidal/O effects/O induced/O by/O neuroleptics/O has/O been/O studied/O in/O 32/O acute/O psychotic/O states/O ./O
Epididymal/O growth/O was/O retarded/O in/O animals/O maintained/O solely/O on/O chickpea/O haulm/O and/O improved/O with/O supplementation/O ./O
Two/O patients/O were/O treated/O with/O both/O regimens/O ./O
Results/O obtained/O for/O chloramphenicol/O -/O containing/O preparations/O are/O presented/O ,/O and/O both/O dissolution/O curves/O and/O cup/O -/O plate/O assays/O demonstrate/O that/O chloramphenicol/O has/O far/O superior/O release/O (/O and/O hence/O activity/O )/O from/O creams/O than/O from/O ophthalmic/O ointments/O ./O
IgG/I levels/O of/O 1/O //O 100/O were/O present/O in/O only/O four/O out/O of/O ten/O samples/O obtained/O 150/O days/O after/O the/O clinical/O onset/O ./O
Letter/O :/O Perspectives/O in/O bone/O marrow/O transplantation/O ./O
Assessment/O of/O the/O carcinogenicity/O of/O non/O -/O nutritive/O sweetners/O II/O :/O Cyclamates/O and/O cyclohexylamine/O ./O
The/O discordant/O behaviour/O in/O weakly/O infected/O mice/O was/O due/O to/O the/O occurrence/O in/O some/O animals/O of/O a/O second/O phase/O of/O more/O rapid/O increase/O of/O the/O parasitemia/O ./O
Residual/O amphotericin/O B/O was/O detected/O in/O the/O feces/O of/O the/O mice/O only/O while/O they/O were/O receiving/O the/O 0/O ./O 3/O mg/O //O ml/O dose/O level/O ./O
There/O was/O a/O slight/O increase/O in/O total/O transferrin/I 2/O hr/O after/O 1/O tablet/O and/O values/O remained/O high/O throughout/O the/O experiment/O ./O
Following/O intravenous/O administration/O ,/O the/O myocardial/O concentration/O of/O tracer/O thallium/O -/O 201/O ,/O potassium/O -/O 43/O ,/O and/O rubidium/O -/O 81/O were/O determined/O in/O mice/O ;/O thallium/O was/O present/O in/O the/O greatest/O concentration/O in/O the/O myocardium/O (/O 2/O ./O 08/O %/O compared/O 1/O ./O 25/O %/O for/O potassium/O and/O 1/O ./O 15/O %/O for/O rubidium/O at/O 10/O minutes/O )./O
Thromboplastin/I time/O ,/O partial/O thromboplastin/I time/O ,/O thrombin/I time/O ,/O heat/O -/O dependent/O fibrin/I ,/O clot/O retraction/O ,/O and/O clotting/I factors/I II/I ,/I V/I ,/I VIII/I ,/I IX/I ,/I X/I ,/O and/O the/O platelet/O count/O were/O determined/O ./O
The/O data/O support/O the/O notion/O that/O suppression/O of/O images/O during/O binocular/O rivalry/O is/O independent/O in/O both/O eyes/O ./O
Glycogen/O utilization/O was/O increased/O ,/O but/O tissue/O levels/O of/O creatine/O phosphate/O ,/O ATP/O ,/O and/O lactate/O were/O similar/O to/O those/O in/O hearts/O receiving/O normal/O flow/O ./O
The/O records/O from/O 1948/O through/O 1967/O of/O 344/O previously/O untreated/O patients/O with/O squamous/O cell/O carcinoma/O of/O the/O oral/O cavity/O ,/O oropharynx/O ,/O supraglottic/O larynx/O and/O hypopharynx/O who/O had/O clinically/O positive/O cervical/O lymph/O node/O metastases/O staged/O N1/O ,/O N2A/O ,/O or/O N2B/O ,/O and/O whose/O initial/O neck/O treatment/O consisted/O of/O external/O radiation/O therapy/O alone/O were/O reviewed/O ./O
With/O 0/O ./O 5/O vol/O .-%,/O the/O corresponding/O values/O were/O 345/O mumol/O //O 1/O (/O 5/O ./O 72/O mg/O //O 100/O ml/O )/O and/O 137/O mumol/O //O 1/O (/O 2/O ./O 25/O mg/O //O 100/O ml/O )/O respectively/O ./O
The/O authors/O describe/O the/O technique/O of/O transverse/O axial/O tomography/O of/O the/O spine/O and/O give/O a/O detailed/O description/O of/O the/O axial/O anatomy/O of/O the/O normal/O lumbar/O spine/O from/O L/O -/O 4/O to/O the/O sacrum/O ./O
Owing/O to/O parental/O attitude/O ,/O a/O low/O protein/O diet/O (/O 1/O -/O 5/O g/O //O kg/O )/O was/O introduced/O only/O late/O ./O
In/O none/O of/O the/O 44/O type/O I/O attacks/O and/O 29/O type/O II/O attacks/O which/O were/O recorded/O did/O circulatory/O changes/O ;/O the/O latter/O were/O different/O in/O the/O two/O groups/O ./O
A/O clinically/O useful/O diagnostic/O method/O has/O been/O developed/O for/O detecting/O and/O quantitating/O periods/O of/O apnea/O in/O pediatric/O patients/O ./O
The/O other/O hypoglycaemic/O patient/O showed/O an/O exaggerated/O insulin/I release/O in/O response/O to/O tolbutamide/O ./O
Nerve/O stimulation/O (/O 1/O ./O 5/O -/O 12/O cycles/O //O s/O )/O produced/O frequency/O -/O dependent/O reductions/O in/O CBF/O ,/O a/O decrease/O of/O 50/O percent/O occurring/O with/O the/O highest/O frequency/O ./O
Effect/O of/O ingestion/O of/O Norbiogest/O during/O the/O quiescent/O period/O of/O the/O genital/O organs/O
Risk/O of/O infection/O in/O the/O treatment/O of/O fractures/O
Bulbar/O pouches/O were/O perfused/O with/O solutions/O of/O 0/O ./O 9/O %/O Na/O C1/O ,/O 0/O ./O 1/O N/O HC1/O ,/O 40/O %/O glucose/O ,/O 40/O %/O NaC1/O ,/O and/O 40/O %/O peptone/O or/O with/O 0/O ./O 1/O %/O solutions/O of/O acetylcholine/O chloride/O ./O
Liver/O microsomes/O of/O the/O shag/O showed/O smaller/O than/O 8/O %/O of/O the/O epoxide/I hydrase/I activity/O and/O smaller/O than/O 14/O %/O of/O the/O hydroxylating/O capacity/O of/O liver/O microsomes/O from/O the/O rat/O ./O
Prolonged/O heavy/O work/O effected/O an/O increase/O of/O 10/O ./O 3/O plus/O or/O minus/O 0/O ./O 9/O mmHg/O in/O in/O vivo/O P50/O (/O 7/O ./O 30/O PH/O -/O v/O ,/O 41/O degrees/O C/O -/O v/O ,/O and/O 45/O Pv/O -/O CO2/O );/O due/O entirely/O to/O the/O additive/O effects/O of/O increased/O venous/O temperature/O and/O [/O H/O +]./O
A/O clinical/O ,/O serological/O and/O prognostic/O study/O
The/O American/O Burkitt/O Lymphoma/O Registry/O :/O a/O progress/O report/O ./O
Vitrectomy/O with/O an/O alternative/O instrument/O system/O ./O
The/O metabolic/O clearance/O rate/O of/O progesterone/O was/O 295/O +/-/O 49/O (/O S/O ./O E/O .)/O 1/O //O day/O ./O
This/O sequence/O is/O almost/O identical/O with/O that/O of/O human/I luteinizing/I hormone/I (/O Sairam/O ,/O M/O ./O
The/O mean/O plasma/O sodium/O concentration/O which/O was/O 135/O ./O 95/O (+/-/O SD/O 4/O ./O 14/O )/O mEq/O //O kg/O before/O diuretic/O treatment/O was/O significantly/O decreased/O during/O treatment/O to/O 129/O ./O 19/O (+/-/O SD/O 2/O ./O 77/O )/O mEq/O //O kg/O ,/O P/O less/O than/O 0/O ./O 001/O ./O
Editorial/O :/O Low/O -/O dose/O heparin/O and/O the/O prevention/O of/O venous/O thromboembolic/O disease/O ./O
At/O the/O very/O high/O dose/O levels/O used/O ,/O sodium/O saccharin/O and/O sodium/O cyclamate/O were/O weak/O solitary/O carcinogens/O producing/O 4/O //O 253/O and/O 3/O //O 228/O bladder/O tumours/O respectively/O ,/O and/O the/O first/O of/O these/O tumours/O did/O not/O appear/O for/O more/O than/O 80/O weeks/O ./O
Effects/O of/O perceptual/O salience/O on/O the/O matrix/O task/O performance/O of/O four/O -/O and/O six/O -/O year/O -/O old/O children/O ./O
Glucose/I -/I 6/I -/I phosphate/I dehydrogenase/I (/O G/I -/I 6/I -/I PD/I )/O deficiency/O in/O the/O newborn/O ./O
The/O eluting/O solvent/O was/O methanol/O -/O chloroform/O (/O 10/O +/O 90/O )/O at/O a/O flow/O rate/O of/O 2/O ./O 0/O ml/O //O min/O ./O
The/O bronchial/O epithelia/O of/O all/O smoke/O -/O exposed/O animals/O were/O hyperplastic/O ,/O and/O their/O ultrastructure/O showed/O invaginations/O ,/O tilt/O of/O nuclear/O axes/O ,/O an/O increase/O in/O the/O number/O and/O size/O of/O lysosomes/O and/O multivesiculated/O bodies/O ,/O and/O increased/O numbers/O of/O enlarged/O intramitochondrial/O granules/O ./O
The/O routine/O administration/O of/O fat/O -/O soluble/O vitamins/O appears/O unnecessary/O but/O it/O is/O prudent/O to/O measure/O prothrombin/I time/O and/O serum/O vitamins/O A/O and/O E/O at/O intervals/O ./O
Prostaglandins/O F/O (/O PGF/O )/O were/O measured/O in/O uterine/O vein/O ,/O ovarian/O artery/O ,/O and/O jugular/O vein/O plasma/O and/O in/O the/O endometrial/O tissues/O at/O various/O times/O during/O the/O bovine/O estrous/O cycle/O ,/O and/O were/O compared/O to/O peripheral/O plasma/O progesterone/O levels/O ./O
Before/O this/O date/O ,/O the/O drug/O directly/O inhibits/O fetal/O weight/O gain/O ,/O whereas/O the/O sensitivity/O of/O the/O placenta/O is/O only/O transient/O at/O day/O 16/O resulting/O in/O maximum/O weight/O decrease/O of/O this/O organ/O 24/O h/O later/O ./O
Groups/O of/O ten/O dependent/O and/O ten/O saline/O mice/O were/O singly/O tested/O in/O both/O light/O and/O dark/O conditions/O in/O each/O of/O five/O covered/O cylinders/O (/O 2/O -/O 23/O in/O high/O )./O
The/O effects/O initiated/O from/O the/O nucleus/O accumbens/O septi/O were/O most/O marked/O ./O
The/O appearance/O of/O dyskinetic/O movement/O disorders/O in/O humans/O following/O the/O chronic/O use/O of/O levodopa/O or/O amphetamine/O may/O be/O a/O manifestation/O of/O similarly/O increased/O dopamine/I receptor/I site/I sensitivity/O within/O the/O striatum/O ./O
Association/O with/O HL/I -/I A/I W/I -/I 27/I ./O
Letter/O :/O Lactose/O tolerance/O tests/O as/O a/O predictor/O of/O milk/O tolerance/O ./O
Retinoblastoma/O :/O a/O study/O of/O natural/O history/O and/O prognosis/O of/O 268/O cases/O ./O
Like/O pineal/O melatonin/O ,/O serum/O melatonin/O was/O high/O at/O mid/O -/O dark/O and/O low/O at/O mid/O -/O light/O ./O
D/O ./O
Atherosclerosis/O
The/O authors/O concluded/O that/O ultrasonic/O Doppler/O -/O cardiography/O can/O be/O used/O for/O measuring/O the/O relative/O changes/O in/O the/O stroke/O volume/O ./O
The/O attainment/O of/O sexual/O maturity/O in/O terms/O of/O secondary/O sexual/O characteristics/O ,/O the/O production/O of/O spermatozoa/O in/O the/O male/O ,/O and/O the/O cyclical/O female/O pattern/O with/O release/O of/O ova/O are/O end/O -/O points/O of/O the/O developmental/O process/O ./O
However/O ,/O a/O 10/O --/O 15/O %/O lengthening/O of/O the/O partial/O thromboplastin/I time/O is/O evident/O after/O 24/O hours/O of/O storage/O ./O
Caution/O should/O be/O exercised/O in/O the/O use/O of/O these/O dyes/O for/O lymphograms/O ./O
This/O reveals/O a/O new/O test/O for/O short/O saphenous/O incompetence/O and/O shows/O that/O 14/O per/O cent/O of/O varices/O stem/O from/O a/O saphenopopliteal/O reflux/O ./O
Three/O groups/O of/O patients/O who/O had/O undergone/O subtotal/O thyroidectomy/O for/O Graves/O '/O s/O disease/O ,/O toxic/O multinodular/O goitre/O ,/O or/O euthyroid/O multinodular/O goitre/O 12/O to/O 15/O years/O before/O and/O in/O whom/O a/O normal/O serum/O thyroxine/O (/O T/O -/O 4/O )/O level/O was/O found/O were/O each/O divided/O into/O two/O subgroups/O on/O the/O basis/O of/O a/O normal/O or/O a/O raised/O serum/O thyrotrophin/I concentration/O ./O
Routine/O isotope/O cystography/O using/O 99M/O Tc/O sulfur/O colloid/O for/O detection/O and/O follow/O -/O up/O of/O vesico/O -/O ureteral/O reflux/O
Air/O ion/O action/O on/O bacteria/O ./O
No/O evidence/O of/O either/O positive/O or/O negative/O chemography/O was/O found/O ./O
The/O interpretation/O of/O antibiotic/O disc/O sensitivities/O ./O
Following/O retransfusion/O ,/O the/O affected/O epithelial/O lining/O appeared/O greatly/O distended/O over/O the/O oedematous/O lamina/O propria/O ,/O with/O almost/O complete/O loss/O of/O structural/O detail/O ./O
A/O study/O of/O chromosomes/O of/O lymphocytes/O from/O patients/O treated/O with/O hycanthone/O ./O
Characteristics/O of/O anesthesia/O and/O resuscitation/O in/O emergency/O lung/O surgery/O
Study/O of/O the/O physico/O -/O chemical/O state/O of/O plutonium/O -/O 239/O in/O a/O citrate/O solution/O -/O blood/O system/O
Tobramycin/O 60/O mg/O did/O not/O show/O any/O remarkable/O effect/O ,/O but/O dibecacin/O 100/O mg/O produced/O a/O slight/O potentiating/O effect/O on/O the/O action/O of/O d/O -/O tubocurarine/O ./O
In/O about/O one/O third/O of/O the/O cases/O this/O operation/O results/O in/O tonal/O and/O vocal/O improvement/O for/O patients/O suffering/O from/O progressive/O perceptive/O deafness/O ./O
The/O specific/O electrical/O resistance/O of/O the/O cerebrospinal/O fluid/O was/O measured/O by/O means/O of/O conductometry/O in/O 14/O cases/O of/O meningitis/O purulenta/O ,/O 17/O cases/O of/O meningitis/O serosa/O ,/O 10/O cases/O of/O encephalitis/O and/O in/O 32/O control/O subjects/O ./O
2/O -/O Chemical/O occlusion/O of/O vas/O is/O quite/O effective/O in/O producing/O a/O block/O in/O the/O vas/O deferens/O of/O dogs/O ./O
Besides/O ,/O we/O found/O in/O 3/O patients/O increased/O serum/I immunoglobulins/I ,/O chiefly/O IgG/I ,/O as/O first/O Russe/O ,/O Busey/O and/O Barbeau/O demonstrated/O in/O a/O large/O French/O -/O Canadian/O family/O ./O
We/O suggest/O that/O such/O occlusions/O occurred/O at/O the/O time/O of/O the/O infarction/O ./O
Streptococcal/O preparation/O (/O OK/O -/O 432/O ),/O a/O new/O type/O of/O anti/O -/O cancer/O agent/O ,/O was/O given/O to/O the/O patients/O with/O advanced/O cancer/O in/O combination/O with/O Mitomycin/O -/O C/O ,/O 5/O -/O FU/O and/O Cytosine/O arabinoside/O ./O
Generally/O ,/O a/O correlation/O was/O observed/O between/O highest/O concentrations/O of/O CSF/I immunoglobulins/I and/O degree/O of/O meningeal/O inflammatory/O response/O ,/O even/O if/O this/O was/O a/O component/O of/O other/O neurological/O diseases/O ./O
Maternal/O lactation/O
Experimental/O cardiotoxicity/O of/O adriamycin/O
Muscular/O pathology/O
Demonstration/O of/O the/O agent/O was/O performed/O from/O the/O 6th/O to/O the/O 11th/O day/O p/O ./O i/O ./O by/O direct/O microscopic/O methods/O (/O Stamp/O and/O auramine/O staining/O ,/O fluorescent/O antibody/O technique/O );/O the/O Coxiella/O content/O was/O determined/O by/O titration/O in/O embryonated/O hen/O '/O s/O eggs/O ./O
The/O patients/O were/O divided/O into/O 4/O groups/O receiving/O NLA/O II/O with/O or/O without/O nalorphine/O ,/O morphine/O or/O Micoren/O ./O
The/O alterations/O of/O 5/O -/O HT/O and/O 5/O -/O HIAA/O levels/O in/O several/O regions/O of/O the/O brain/O under/O the/O conditions/O examined/O may/O indicate/O that/O IDPN/O '/O s/O neurotoxicity/O primarily/O affects/O 5/O -/O HT/O -/O containing/O neurones/O ./O
(/O 5/O )/O An/O increase/O in/O leukocyte/O -/O counts/O occurred/O on/O the/O administration/O of/O serum/O obtained/O from/O rabbit/O during/O phase/O -/O 2/O ./O
The/O results/O obtained/O tend/O to/O prove/O that/O the/O reticuloendothelial/O system/O mainly/O participated/O in/O beryllium/O retention/O ./O
In/O both/O cases/O ,/O at/O the/O end/O of/O exposure/O the/O same/O level/O of/O blood/I carboxyhemoglobin/I (/O COHb/I )/O (/O about/O 50/O %)/O was/O reached/O ./O
The/O results/O indicate/O that/O increased/O pulmonary/O blood/O flow/O and/O decreased/O pulmonary/O vascular/O resistance/O with/O advancing/O gestation/O are/O due/O to/O an/O increase/O in/O the/O total/O number/O of/O vessels/O and/O increased/O vasomotor/O reactivity/O is/O related/O to/O an/O increase/O in/O the/O total/O amount/O of/O smooth/O muscle/O while/O the/O thickness/O of/O muscle/O in/O individual/O vessels/O remains/O constant/O ./O
Reduction/O in/O dosage/O restored/O normal/O taste/O sense/O in/O all/O three/O ,/O but/O in/O two/O the/O drug/O had/O to/O be/O discontinued/O because/O of/O persisting/O high/O transaminase/O levels/O ./O
The/O calcium/O ratio/O (/O mean/O ratio/O of/O the/O predicted/O to/O measured/O TBCa/O )/O in/O men/O was/O 1/O ./O 000/O +/-/O 7/O ./O 8/O %/O and/O in/O women/O 0/O ./O 996/O +/-/O 7/O ./O 1/O %./O
A/O late/O diagnosis/O of/O retinoblastoma/O is/O an/O unquestionable/O fact/O that/O allows/O its/O growth/O and/O leads/O to/O a/O deterioration/O in/O the/O outlook/O ./O
Total/O cholesterol/O was/O measured/O in/O amniotic/O fluids/O collected/O at/O different/O stages/O of/O gestation/O ./O
Her/O serum/O FT3/O concentration/O was/O ,/O however/O ,/O much/O higher/O than/O the/O ranges/O in/O normal/O pregnancy/O or/O in/O GTD/O patients/O without/O clinical/O hyperthyroidism/O ./O
The/O authors/O found/O that/O except/O for/O fear/O and/O pugnacity/O all/O husband/O -/O wife/O trait/O correlations/O were/O positive/O ,/O in/O contrast/O to/O Winch/O '/O s/O principle/O of/O type/O I/O complementarity/O ./O
A/O note/O on/O the/O phase/O -/O plane/O technique/O representation/O of/O cardiac/O action/O potentials/O ./O
3/O activities/O of/O the/O factor/I II/I molecule/O in/O the/O newborn/O infant/O at/O term/O
The/O concept/O of/O "/O structural/O identifiability/O "/O is/O employed/O in/O this/O analysis/O to/O determine/O which/O model/O parameters/O can/O be/O and/O which/O cannot/O be/O determined/O "/O uniquely/O "/O from/O given/O input/O -/O output/O data/O ;/O a/O step/O -/O by/O -/O step/O procedure/O based/O on/O an/O extension/O of/O this/O concept/O is/O presented/O for/O adapting/O the/O overall/O approach/O to/O the/O experimental/O design/O problem/O ./O
However/O ,/O we/O did/O detect/O lot/O -/O to/O -/O lot/O variation/O and/O differences/O in/O performance/O between/O narrow/O bandpass/O and/O wide/O bandpass/O spectrophotometers/O ./O
The/O cochlear/O compromise/O ./O
A/O case/O observed/O in/O Saigon/O
Hypertonic/O glucose/O administered/O intrajejunally/O in/O Heidenhain/O pouch/O dogs/O resulted/O in/O an/O equal/O inhibition/O of/O pentagastrin/O -/O induced/O acid/O secretion/O from/O the/O pouch/O and/O the/O main/O stomach/O ,/O whereas/O hypertonic/O saline/O had/O no/O effect/O ./O
Acquired/O factor/I VIII/I inhibitor/O in/O non/O -/O hemophilic/O patients/O
Biohydrogenation/O of/O linoleic/O acid/O into/O octadecenoic/O acid/O was/O observed/O ./O
The/O study/O of/O calcium/O metabolism/O in/O ten/O thalassaemic/O children/O comperatively/O with/O controls/O after/O oral/O administration/O of/O 47Ca/O has/O shown/O diminished/O intestinal/O absorption/O ./O
Chlamydial/O agents/O were/O isolated/O from/O the/O semen/O near/O the/O end/O of/O the/O chlamydemic/O phase/O ./O
Because/O of/O the/O increased/O CPK/I activity/O found/O in/O normal/O newborns/O ,/O screening/O for/O Duchenne/O -/O type/O muscular/O dystrophy/O should/O be/O postponed/O for/O a/O few/O weeks/O after/O delivery/O ./O
In/O contrast/O ,/O the/O insulin/I response/O had/O returned/O to/O the/O non/O -/O pregnant/O value/O by/O the/O second/O day/O of/O the/O puerperium/O ./O
The/O authors/O report/O the/O results/O of/O a/O series/O of/O toxicological/O tests/O conducted/O on/O plastic/O materials/O (/O polyethylene/O )/O activated/O with/O tetraphenylbutadiene/O (/O TPB/O )/O an/O additive/O recently/O proposed/O as/O a/O sensitizer/O capable/O of/O photodegrading/O plastic/O materials/O ./O
Mutational/O analysis/O of/O the/O major/O homology/O region/O of/O Mason/O -/O Pfizer/O monkey/O virus/O by/O use/O of/O saturation/O mutagenesis/O ./O
One/O site/O ,/O PAL/I ,/O occurs/O within/O the/O 10/O bp/O sequence/O GGGGAGGAGG/O ./O
Nuclear/O extracts/O prepared/O from/O both/O neural/O and/O non/O -/O neural/O cell/O lines/O ,/O mouse/O brain/O ,/O and/O mouse/O liver/O contain/O proteins/O that/O recognize/O and/O bind/O to/O the/O PROX/O and/O PAL/O sequences/O indicating/O that/O proteins/O which/O bind/O to/O these/O target/O sequences/O are/O widespread/O ./O
To/O determine/O if/O the/O NF/I (/I H/I )/I promoter/I can/O be/O activated/O in/O a/O tissue/O specific/O manner/O during/O development/O transgenic/O mice/O containing/O the/O promoter/O region/O linked/O to/O a/O beta/I -/I galactosidase/I reporter/I gene/I were/O generated/O ./O
Here/O we/O describe/O and/O map/O two/O more/O new/O genes/O identified/O as/O allele/O -/O specific/O suppressors/O that/O compensate/O for/O carboxy/O -/O terminal/O truncation/O of/O PET122/I ./O
Previous/O studies/O have/O shown/O [/O Hisanaga/O ,/O S/O .,/O Kusubata/O ,/O M/O .,/O Okumura/O ,/O E/O ./O &/O Kishimoto/O ,/O T/O ./O
Treatment/O and/O staining/O of/O smears/O and/O sections/O for/O detection/O of/O microorganisms/O
The/O apparent/O Kd/O of/O the/O MetRS/I //I CAU/I operator/I complex/I is/O one/O order/O magnitude/O higher/O than/O that/O of/O the/O ThrRS/I //I CGU/I operator/I complex/I ./O
A/O significant/O direct/O relationship/O was/O observed/O between/O the/O percent/O area/O density/O of/O smooth/O muscle/O and/O the/O percent/O change/O in/O peak/O urinary/O flow/O rate/O ./O
Rabbit/I skeletal/I muscle/I glycogenin/I ./O
Characterization/O of/O the/O human/I gene/I encoding/I cytokeratin/I 17/I and/O its/O expression/O pattern/O ./O
Animals/O that/O received/O DSP/O -/O 4/O were/O significantly/O retarded/O in/O motor/O recovery/O compared/O with/O the/O saline/O group/O ./O
The/O prophylactic/O use/O of/O new/O medication/O for/O patients/O between/O the/O first/O and/O second/O cycle/O of/O chemotherapy/O ,/O in/O agreement/O with/O the/O estimates/O calculated/O ,/O does/O not/O save/O health/O care/O costs/O but/O may/O improve/O the/O quality/O of/O life/O in/O these/O patients/O and/O permit/O the/O continuation/O of/O a/O therapeutic/O schedule/O without/O interruption/O which/O may/O improve/O the/O life/O expectancy/O of/O the/O patient/O ./O
AP/O was/O induced/O by/O intraductal/O infusion/O of/O two/O different/O concentrations/O of/O glycodeoxycholic/O acid/O (/O GDOC/O 17/O mmol/O and/O 34/O mmol/O )./O
The/O isolation/O of/O this/O gene/O was/O based/O on/O the/O identification/O of/O the/O Y/O -/O 231/O cosmid/O that/O contains/O CpG/O rich/O sequences/O (/O HTF/O islands/O )/O in/O its/O human/O insert/O ./O
Tissue/I plasminogen/I activator/I ,/O its/O inhibitor/O and/O other/O parameters/O of/O fibrinolysis/O in/O blood/O of/O patients/O operated/O for/O mild/O hypertrophy/O of/O the/O prostate/O
Gene/O constructs/O consisting/O of/O human/I growth/I hormone/I (/O hGH/I )/O gene/O driven/O by/O promoter/O //O regulatory/O sequence/O of/O mouse/I metallothionein/I (/O mMT/I ),/O viral/I thymidine/I kinase/I (/O vTK/I ),/O rat/I cholecystokinin/I (/O rCCK/I ),/O or/O chicken/I beta/I -/I actin/I (/O cBA/I )/O gene/O were/O injected/O into/O the/O cytoplasm/O of/O fertilized/O medaka/O eggs/O via/O the/O micropyle/O ./O
Serum/O gastrin/I and/O AFP/I levels/O had/O the/O same/O evolution/O and/O appear/O to/O have/O the/O same/O interest/O to/O follow/O the/O course/O of/O the/O disease/O ./O
Prospects/O for/O controlled/O -/O delivery/O systems/O ./O
The/O mean/O (+/-/O SD/O )/O PaO2/O increased/O from/O 80/O ./O 8/O +/-/O 26/O ./O 9/O mmHg/O before/O to/O 89/O ./O 8/O +/-/O 27/O ./O 3/O mmHg/O after/O the/O infusion/O (/O P/O /O IgG3/I >/O IgG4/I ),/O with/O only/O the/O magnitude/O of/O the/O individual/O subclass/O responses/O being/O increased/O in/O coeliac/O patients/O ./O
Examination/O of/O ANCA/I is/O not/O only/O a/O significant/O contribution/O towards/O a/O more/O accurate/O diagnosis/O of/O renal/O vasculitis/O ,/O but/O also/O an/O indicator/O of/O the/O activity/O of/O the/O disease/O and/O thus/O of/O the/O effectiveness/O of/O immunosuppressive/O treatment/O ./O
On/O the/O other/O hand/O ,/O total/O pinealectomy/O in/O these/O already/O sympathectomized/O blinded/O rabbits/O always/O resulted/O in/O a/O substantial/O deceleration/O of/O the/O rhythms/O (/O mean/O delta/O tau/O =/O +/O 0/O ./O 23/O h/O )./O
Cicatricial/O pemphigoid/O is/O an/O autoimmune/O systemic/O disease/O characterized/O by/O chronic/O conjunctival/O cicatrization/O ./O
The/O effects/O of/O two/O levels/O of/O caffeine/O ingestion/O on/O excess/O postexercise/O oxygen/O consumption/O in/O untrained/O women/O ./O
The/O distinguishing/O features/O involved/O eight/O amino/O acid/O changes/O ,/O including/O a/O single/O lysine/O deletion/O relative/O to/O a/O primate/O consensus/O sequence/O in/O the/O first/O complementary/O -/O determing/O region/O of/O V1J1/I ./O
4/O ./O
The/O in/O vivo/O profile/O of/O ZFH/I -/I 2/I in/O the/O larval/O CNS/O shows/O intriguing/O overlap/O with/O DDC/I in/O specific/O serotonin/O and/O dopamine/O neurons/O ./O
Unlike/O the/O introns/O of/O other/O duplicated/O ribosomal/I protein/I genes/I which/O are/O highly/O diverged/O ,/O the/O duplicated/O S13/I genes/I have/O two/O nearly/O identical/O DNA/O sequences/O of/O 25/O and/O 31/O bp/O in/O length/O within/O their/O introns/O ./O
In/O a/O prospective/O ,/O randomized/O clinical/O trial/O we/O compared/O the/O efficacy/O of/O subcutaneously/O (/O SC/O )/O administered/O (/O every/O 8/O h/O )/O calcium/O heparin/O to/O intravenous/O (/O IV/O )/O sodium/O heparin/O in/O the/O treatment/O of/O proximal/O deep/O -/O vein/O thrombosis/O (/O DVT/O )./O
The/O highest/O prevalence/O of/O reported/O pet/O allergy/O ,/O chronic/O cough/O ,/O wheeze/O ,/O attacks/O of/O shortness/O of/O breath/O with/O wheezing/O ,/O and/O doctor/O -/O diagnosed/O asthma/O was/O found/O in/O children/O who/O had/O pets/O in/O the/O past/O but/O not/O anymore/O ./O
Therefore/O ,/O it/O would/O be/O advantageous/O to/O identify/O such/O persons/O and/O treat/O them/O preferentially/O ./O
On/O the/O basis/O of/O these/O unique/O properties/O ,/O the/O newly/O characterized/O hemagglutinin/I has/O been/O termed/O Limulus/I 18K/I agglutination/I -/I aggregation/I factor/I (/O 18K/I -/I LAF/I )./O
The/O shift/O to/O the/O nonpermissive/O temperature/O is/O accompanied/O by/O the/O loss/O of/O guanyl/O nucleotide/O -/O dependent/O activity/O of/O adenylylcyclase/I in/O vitro/O ./O
Clin/O ./O
The/O data/O indicate/O that/O the/O minimal/O catalytic/O domain/O of/O Nmt1p/I is/O located/O between/O Ile59/O -->/O Phe96/O and/O Gly451/O -->/O Leu455/O ./O
It/O corresponds/O to/O the/O complete/O mitochondrial/O presequence/O and/O the/O lipoyl/O -/O bearing/O domain/O that/O are/O encoded/O by/O exons/O I/O through/O IV/O of/O the/O functional/O E2/I gene/I ./O
Human/O neutrophil/O response/O to/O short/O -/O term/O exposure/O to/O F/O -/O 75/O cobalt/O -/O based/O alloy/O ./O
Disruption/O of/O microtubules/O did/O not/O affect/O the/O fidelity/O or/O kinetics/O of/O vacuolar/O protein/O sorting/O ,/O indicating/O that/O Vps1p/I function/O is/O not/O dependent/O on/O microtubules/O ./O
A/O mutant/O form/O of/O Vps1p/I lacking/O the/O entire/O GTP/O -/O binding/O domain/O interfered/O with/O vacuolar/O protein/O sorting/O in/O wild/O -/O type/O cells/O ./O
According/O to/O out/O field/O research/O ,/O the/O tick/O fauna/O was/O very/O rich/O throughout/O that/O area/O ,/O and/O it/O was/O permissible/O enough/O to/O determine/O ticks/O as/O the/O vectors/O ,/O based/O on/O arising/O of/O anti/I -/I SF/I group/I rickettsiae/I (/O SFGR/I )/O antibody/O in/O mice/O inoculated/O with/O some/O tick/O emulsions/O ,/O findings/O of/O rickettsiae/O reactive/O to/O patient/O sera/O or/O a/O species/O -/O specific/O monoclonal/O antibody/O to/O JSFR/I in/O the/O hemolymph/O cells/O of/O some/O ticks/O ,/O and/O electron/O microscopical/O observations/O of/O SFGR/I in/O various/O internal/O organs/O including/O the/O salivary/O gland/O of/O ticks/O ./O
The/O second/O method/O ,/O the/O "/O macro/O "/O assay/O ,/O has/O a/O sensitivity/O range/O of/O 0/O ./O 03/O -/O 5/O ./O 0/O micrograms/O phosphorus/O with/O 100/O -/O 500/O microliters/O HClO4/O ./O
Nucleotide/O sequence/O and/O transcriptional/O analysis/O of/O the/O polyhedrin/I gene/I of/O Spodoptera/O exigua/O nuclear/O polyhedrosis/O virus/O ./O
Validation/O of/O automated/O systems/O --/O system/O definition/O ./O
As/O a/O consequence/O of/O dark/O rearing/O ,/O the/O numerical/O density/O of/O cortical/O neurons/O in/O area/O 17/O amounted/O to/O about/O double/O of/O the/O value/O observed/O in/O normally/O reared/O kittens/O and/O was/O also/O significantly/O higher/O in/O area/O 18/O ./O
These/O results/O suggest/O that/O decreased/O class/O I/O enhancer/O activity/O in/O Ad12/O -/O transformed/O cells/O may/O ,/O at/O least/O in/O part/O ,/O be/O due/O to/O the/O higher/O levels/O of/O an/O enhancer/O -/O specific/O factor/O ,/O possibly/O acting/O as/O a/O repressor/O ./O
A/O second/O domain/O ,/O located/O in/O the/O C/O -/O terminal/O 437/O amino/O acids/O of/O IE1/I ,/O is/O required/O for/O inhibitory/O and/O DNA/O -/O binding/O activities/O ./O
In/O order/O to/O investigate/O the/O blood/O compatibility/O of/O autogenous/O vein/O graft/O (/O AVG/O ),/O changes/O in/O prostacyclin/O (/O PGI2/O )/O production/O following/O harvesting/O and/O arterial/O implantation/O were/O studied/O experimentally/O ./O
Subcutaneous/O administration/O of/O the/O somatostatin/I analogue/O ,/O octreotide/O ,/O 100/O micrograms/O thrice/O daily/O ,/O resulted/O in/O a/O sustained/O improvement/O in/O diarrhoea/O and/O disappearance/O of/O faecal/O incontinence/O without/O reducing/O calcitonin/I levels/O ./O
Anti/I -/I CRK/I antibodies/I detect/O a/O 53kDa/O protein/O in/O extracts/O of/O C/O ./O fasciculata/O in/O agreement/O with/O the/O size/O predicted/O from/O the/O nucleotide/O sequence/O of/O the/O cloned/O gene/O ./O
205/O ,/O 285/O -/O 290/O ]/O and/O was/O subsequently/O cloned/O and/O sequenced/O [/O J/O ./O
Nonreplicating/O vaccinia/O vector/O efficiently/O expresses/O recombinant/O genes/O ./O
Use/O of/O free/O -/O access/O minerals/O ./O
Interferon/I type/I I/I in/O protective/O body/O reactions/O in/O an/O experimental/O Klebsiella/O infection/O
No/O other/O changes/O in/O hematopoietic/O differentiation/O status/O were/O observed/O in/O association/O with/O Id/I -/I SCL/I expression/O ./O
Respiratory/O interaction/O after/O spinal/O anesthesia/O and/O sedation/O with/O midazolam/O ./O
For/O pressure/O greater/O than/O 121/O atm/O abs/O ,/O an/O increased/O excitability/O of/O the/O tadpoles/O made/O it/O difficult/O to/O distinguish/O the/O righting/O reflex/O from/O involuntary/O movements/O ./O
One/O air/O embolism/O occurred/O ;/O this/O was/O the/O only/O filter/O -/O or/O retrieval/O -/O related/O complication/O ./O
The/O 5/O '/O region/O of/O ADH5/I contains/O consensus/O binding/O sites/O for/O the/O transcriptional/O regulatory/O proteins/O ,/O Sp1/I ,/O AP2/I ,/O LF/I -/I A1/I ,/O NF/I -/I 1/I ,/O NF/I -/I A2/I ,/O and/O NF/I -/I E1/I ./O
V/O ./O
These/O data/O indicate/O that/O RNK/I -/I Met/I -/I 1/I is/O a/O serine/I protease/I with/O unique/O activity/O that/O is/O expressed/O in/O the/O granules/O of/O large/O granular/O lymphocytes/O ./O
Purification/O and/O cloning/O of/O a/O novel/O serine/I protease/I ,/O RNK/I -/I Met/I -/I 1/I ,/O from/O the/O granules/O of/O a/O rat/O natural/O killer/O cell/O leukemia/O ./O
We/O describe/O here/O 17/O dominant/I GCN2/I mutations/I that/O lead/O to/O derepression/O of/O GCN4/I expression/O in/O the/O absence/O of/O amino/O acid/O starvation/O ./O
Administration/O of/O growth/I hormone/I leads/O to/O faster/O growth/O ,/O but/O also/O faster/O bone/O maturation/O ./O
Comparisons/O with/O the/O available/O amino/O acid/O residue/O (/O aa/O )/O sequence/O information/O from/O the/O complete/O CPMV/I RNA/I 1/I sequence/I and/O the/O partial/O sequence/O of/O red/I clover/I mottle/I virus/I RNA/I 1/I suggest/O that/O CPSMV/I RNA/I 1/I specifies/O the/O expected/O set/O of/O five/O mature/O proteins/O :/O 32K/I proteinase/I cofactor/I ,/O 58K/I presumed/I helicase/I ,/O VPg/I 5/I '-/I linked/I protein/I of/O the/O genomic/O RNAs/O ,/O 24K/I proteinase/I ,/O and/O 87K/I presumed/I polymerase/I ,/O separated/O by/O four/O cleavage/O sites/O ./O
Rice/I dwarf/I phytoreovirus/I segment/I S12/I transcript/I is/O tricistronic/O in/O vitro/O ./O
In/O addition/O ,/O the/O utility/O of/O beta/I 2/I transferrin/I assay/O in/O the/O diagnosis/O of/O cerebrospinal/O fluid/O otorrhea/O is/O presented/O ./O
Cold/O cardioplegia/O was/O administered/O at/O 45/O mm/O Hg/O every/O 20/O minutes/O for/O 2/O hours/O ./O
The/O addition/O of/O diatrizoate/O to/O the/O IPRK/O led/O to/O a/O dose/O -/O dependent/O biphasic/O change/O in/O RPF/O and/O GFR/O characterized/O by/O an/O initial/O transient/O increase/O followed/O by/O a/O marked/O and/O sustained/O decrease/O ./O
To/O prepare/O for/O analyses/O with/O the/O family/O variables/O ,/O we/O next/O present/O descriptive/O data/O based/O on/O separate/O principal/O components/O analysis/O (/O PCA/O )/O and/O multidimensional/O scaling/O analysis/O (/O MDS/O )/O of/O 14/O self/O -/O reported/O health/O scores/O for/O husbands/O and/O for/O wives/O ./O
The/O structural/O genes/O encoding/O glyceraldehyde/I -/I 3/I -/I phosphate/I dehydrogenase/I (/O GAPDH/I ),/O 3/I -/I phosphoglycerate/I kinase/I (/O PGK/I )/O and/O the/O N/O -/O terminal/O part/O of/O triosephosphate/I isomerase/I (/O TIM/I )/O from/O mesophilic/O Bacillus/O megaterium/O DSM319/O have/O been/O cloned/O as/O a/O gene/O cluster/O (/O gap/I operon/I )/O by/O complementation/O of/O an/O Escherichia/O coli/O gap/I amber/I mutant/I ./O
Pseudomonas/I aeruginosa/I exotoxin/I A/I :/O its/O role/O in/O retardation/O of/O wound/O healing/O :/O the/O 1992/O Lindberg/O Award/O ./O
Laboratory/O studies/O showed/O that/O the/O direct/O fluorescent/O -/O antibody/O kits/O were/O the/O least/O sensitive/O in/O this/O case/O and/O did/O not/O detect/O fewer/O than/O 10/O (/O 4/O )/O elementary/O bodies/O per/O ml/O ,/O while/O most/O ELISA/O kits/O detected/O between/O 130/O and/O 600/O elementary/O bodies/O per/O ml/O ./O
To/O study/O the/O significance/O of/O these/O domains/O and/O the/O overall/O evolutionary/O conservation/O of/O the/O gene/O ,/O the/O homolog/O from/O Drosophila/O melanogaster/O was/O isolated/O by/O low/O stringency/O hybridizations/O using/O two/O flanking/O probes/O of/O the/O human/I ERCC3/I cDNA/I ./O
Mono/O -/O ADP/O -/O ribosylation/O is/O a/O reversible/O modification/O of/O proteins/O ,/O with/O NAD/O :/O arginine/I ADP/I -/I ribosyltransferases/I (/O EC/I 2/I ./I 4/I ./I 2/I ./I 31/I )/O and/O ADP/I -/I ribosylarginine/I hydrolases/I (/O EC/I 3/I ./I 2/I ./I 2/I ./I 19/I )/O catalyzing/O the/O opposing/O reactions/O in/O an/O ADP/O -/O ribosylation/O cycle/O ./O
For/O this/O reason/O ,/O the/O particle/O forming/O capacity/O of/O derivatives/O of/O the/O HIV/I -/I 1/I group/I specific/I core/I antigen/I p55/I gag/I was/O assayed/O and/O compared/O dependent/O on/O various/O expression/O systems/O :/O recombinant/O bacteria/O ,/O vaccinia/O -/O and/O baculoviruses/O were/O established/O encoding/O the/O entire/O core/I protein/I p55/I either/O in/O its/O authentic/O sequence/O or/O lacking/O the/O myristylation/O consensus/O signal/O ./O
The/O tramtrack/I (/O ttk/I )/O gene/O of/O Drosophila/O encodes/O 69/O -/O kDa/O and/O 88/O -/O kDa/O proteins/O through/O alternative/O splicing/O of/O the/O primary/O ttk/I transcript/I ./O
Removal/O of/O beta/I 2/I -/I microglobulin/I by/O hemodialysis/O and/O hemofiltration/O :/O a/O four/O year/O follow/O up/O ./O
Removal/O of/O beta/I 2/I -/I microglobulin/I by/O hemodialysis/O and/O hemofiltration/O :/O a/O four/O year/O follow/O up/O ./O
Adapromine/O was/O established/O to/O evoke/O a/O decrease/O of/O the/O amplitude/O of/O the/O dominant/O peak/O and/O dominant/O theta/O -/O activity/O in/O power/O spectra/O of/O the/O EEG/O in/O the/O cortex/O and/O hippocamp/O ,/O with/O an/O increase/O of/O rapid/O wave/O activity/O in/O the/O beta/O 2/O range/O in/O the/O right/O cortex/O and/O hippocamp/O ./O
These/O sequences/O were/O then/O used/O to/O clone/O the/O full/O -/O length/O genes/O from/O a/O yeast/O genomic/O library/O ./O
GAL4/I -/O VP16/I -/O mediated/O antirepression/O required/O an/O auxiliary/O factor/O ,/O denoted/O as/O a/O co/O -/O antirepressor/O ,/O which/O was/O partially/O purified/O from/O Drosophila/O embryos/O ./O
After/O 28/O days/O of/O haloperidol/O treatment/O ,/O similar/O changes/O were/O observed/O for/O delta/O ,/O together/O with/O an/O increase/O of/O alpha/O 1/O ,/O and/O a/O decrease/O of/O fast/O beta/O ./O
Four/O ruminally/O and/O duodenally/O cannulated/O Hampshire/O wethers/O were/O used/O in/O a/O 4/O x/O 4/O Latin/O square/O experiment/O to/O determine/O whether/O linoleoyl/O methionine/O and/O calcium/O linoleate/O would/O increase/O duodenal/O flow/O of/O unsaturated/O fatty/O acids/O (/O C18/O :/O 2/O +/O cis/O C18/O :/O 1/O )./O
Truncated/I ICSBP/I lacking/O the/O first/O 33/O amino/O -/O terminal/O amino/O acids/O fails/O to/O bind/O to/O the/O ICS/I ,/O indicating/O that/O at/O least/O part/O of/O the/O DNA/O binding/O domain/O is/O located/O within/O the/O well/O conserved/O amino/O terminus/O ./O
Therefore/O ,/O ICSBP/I may/O be/O involved/O in/O maintaining/O submaximal/O transcriptional/O activity/O of/O IFN/I -/O inducible/O genes/O in/O hematopoietic/O cells/O ./O
A/O case/O of/O chronic/O hepatitis/O C/O with/O primary/O hypothyroidism/O manifested/O during/O interferon/I treatment/O
Dynamic/O decision/O making/O :/O human/O control/O of/O complex/O systems/O ./O
A/O coiled/I -/I coil/I related/I protein/I specific/O for/O synapsed/O regions/O of/O meiotic/O prophase/O chromosomes/O ./O
Comparable/O amounts/O of/O alpha/I 5/I beta/I 1/I integrin/I were/O isolated/O from/O these/O cells/O by/O chromatography/O of/O detergent/O extracts/O on/O a/O fibronectin/I cell/O -/O binding/O fragment/O affinity/O column/O and/O elution/O with/O EDTA/O ./O
Abstracts/O ./O
These/O results/O indicate/O a/O possible/O involvement/O of/O endogenous/O opioid/O peptides/O in/O the/O cardiac/O effects/O due/O to/O myocardial/O ischaemia/O and/O reperfusion/O ,/O mediated/O by/O opiate/I receptors/I through/O opiate/O antagonism/O ./O
From/O this/O library/O ,/O LEU2/I and/O HIS3/I cDNAs/O were/O recovered/O at/O a/O frequency/O of/O about/O 1/O in/O 10/O (/O 4/O )/O and/O in/O 12/O out/O of/O 13/O cases/O these/O were/O expressed/O in/O a/O galactose/O -/O dependent/O manner/O ./O
Among/O these/O ,/O ACT1/I was/O isolated/O four/O times/O ,/O and/O NSR1/I three/O times/O ./O
Since/O CENP/I -/I B/I gene/I is/O conserved/O in/O mammalian/O species/O and/O CENP/I -/I B/I boxes/I are/O found/O also/O in/O mouse/O centromere/O satellite/O DNA/O (/O minor/O satellite/O ),/O this/O sequence/O -/O specific/O DNA/O -/O protein/O interaction/O may/O be/O important/O for/O some/O kind/O of/O common/O centromere/O function/O ./O
Interestingly/O ,/O a/O portion/O of/O the/O tail/O domain/O (/O aa/O ,/O 1/O ,/O 094/O -/O 1/O ,/O 830/O )/O shares/O 58/O %/O amino/O acid/O sequence/O identity/O with/O a/O 723/O -/O aa/O protein/O from/O mouse/O brain/O reported/O to/O be/O a/O glutamic/I acid/I decarboxylase/I ./O
However/O ,/O in/O the/O subgroup/O with/O normal/O Ht/O (/O or/O =/O 0/O ./O 95/O for/O water/O ,/O fat/O ,/O crude/O protein/O and/O connective/O -/O tissue/O -/O protein/O frei/O meat/O protein/O ,/O and/O >/O or/O =/O 0/O ./O 86/O for/O connective/O -/O tissue/O -/O protein/O ./O
The/O translation/O products/O of/O both/O clones/O are/O highly/O homologous/O to/O APS1/I (/O 66/O and/O 86/O %/O identity/O ,/O respectively/O )/O over/O their/O entire/O lengths/O ,/O including/O amino/O terminal/O sequences/O resembling/O transit/O peptides/O for/O plastid/O localization/O ./O
The/O serum/O levels/O of/O IgE/I ,/O and/O asIgE/I and/O IgG/I -/I 4/I against/O 14/O common/O food/O allergens/O were/O determined/O ./O
Two/O experiments/O investigating/O the/O effects/O of/O short/O -/O term/O spaceflight/O on/O cancellous/O bone/O turnover/O were/O carried/O out/O :/O Physiological/O Systems/O Experiment/O -/O 1/O (/O PSE/O -/O 1/O )/O (/O a/O 4/O -/O d/O orbital/O spaceflight/O )/O and/O PSE/O -/O 2/O (/O a/O 10/O -/O d/O flight/O )./O
That/O sequence/O strongly/O promoted/O the/O transcription/O of/O the/O promotorless/O chloramphenicol/I acetyltranferase/I (/O CAT/I )/O gene/O in/O cells/O of/O pancreatic/O origin/O (/O AR/O -/O 42J/O )/O but/O not/O in/O cells/O of/O non/O -/O pancreatic/O origin/O (/O Rat/O 2/O and/O IEC/O 6/O )./O
Functional/O analysis/O of/O aryl/I hydrocarbon/I receptor/I nuclear/I translocator/I interactions/O with/O aryl/I hydrocarbon/I receptor/I in/O the/O yeast/O two/O -/O hybrid/O system/O ./O
Histopathologic/O observations/O showed/O that/O both/O somatostatin/I and/O triamcinolone/O acetonide/O reduced/O the/O inflammatory/O signs/O in/O the/O joint/O structures/O ,/O although/O triamcinolone/O acetonide/O appeared/O to/O be/O more/O effective/O ./O
An/O approach/O to/O a/O biomathematical/O model/O of/O lymphocytopoiesis/O ./O
The/O influenza/O virus/O NS1/I protein/O is/O a/O unique/O posttranscriptional/O regulator/O that/O has/O two/O activities/O :/O inhibition/O of/O the/O nuclear/O export/O of/O poly/O A/O -/O containing/O mRNAs/O and/O inhibition/O of/O pre/O -/O mRNA/O splicing/O ./O
These/O are/O two/O regions/O of/O known/O conserved/O synteny/O ,/O providing/O further/O evidence/O that/O the/O human/I STEP/I is/O a/O true/O homolog/O of/O the/O murine/I STEP/I gene/I ./O
Molecular/O cloning/O of/O the/O human/O homolog/O of/O a/O striatum/I -/I enriched/I phosphatase/I (/I STEP/I )/I gene/I and/O chromosomal/O mapping/O of/O the/O human/O and/O murine/O loci/O ./O
Carbonic/I anhydrase/I V/I (/O CA/I V/I )/O is/O expressed/O in/O mitochondrial/O matrix/O in/O liver/O and/O several/O other/O tissues/O ./O
Vitamin/O D3/O plus/O nicotine/O treatment/O produced/O parallel/O increases/O in/O cardiac/O mass/O and/O elastic/O modulus/O ,/O with/O a/O significant/O correlation/O between/O the/O two/O ./O
The/O latter/O domain/O appears/O to/O be/O involved/O in/O targeting/O Num1p/I to/O the/O mother/O cell/O cortex/O ./O
This/O finding/O is/O consistent/O with/O the/O notion/O that/O the/O dsRNA/O binding/O domains/O may/O be/O composed/O of/O two/O separate/O functional/O subdomains/O ./O
Preferential/O heterodimeric/O parallel/O coiled/O -/O coil/O formation/O by/O synthetic/I Max/I and/O c/I -/I Myc/I leucine/I zippers/I :/O a/O description/O of/O putative/O electrostatic/O interactions/O responsible/O for/O the/O specificity/O of/O heterodimerization/O ./O
Comparison/O to/O other/O coxI/I genes/I revealed/O a/O 966/O -/O bp/O group/O I/O intron/O ,/O which/O ,/O based/O on/O homology/O with/O the/O related/O yeast/I coxI/I intron/I aI4/I ,/O potentially/O encodes/O a/O 279/O -/O amino/O -/O acid/O site/O -/O specific/O DNA/I endonuclease/I ./O
We/O studied/O the/O GR/I in/O DMS/O -/O 79/O cells/O derived/O from/O a/O human/O ACTH/I -/O secreting/O small/O cell/O lung/O cancer/O ./O
This/O study/O analyzed/O whether/O the/O localization/O of/O an/O accessory/O pathway/O could/O be/O predicted/O by/O using/O the/O polarity/O of/O the/O QRS/O complex/O during/O sinus/O rhythm/O on/O the/O surface/O ECG/O ,/O instead/O of/O the/O delta/O wave/O polarity/O as/O used/O in/O many/O reports/O ./O
The/O promoter/O mutation/O is/O complemented/O in/O trans/O by/O E1A/I products/O of/O the/O heterologous/O helper/O adenovirus/O type/O 5/O (/O Ad5/O )./O
Thus/O ,/O as/O expected/O ,/O trans/O -/O splicing/O depends/O on/O the/O integrity/O of/O U2/I ,/O U4/I ,/O and/O U6/I snRNAs/I ./O
Treatment/O of/O PCC4/O ./O aza1R/O cells/O with/O an/O RAR/I -/O selective/O agonist/O also/O repressed/O the/O expression/O of/O EC/I -/I 1/I mRNA/I while/O treatment/O with/O an/O RXR/I -/O selective/O agonist/O reduced/O EC/I -/I 1/I expression/O slightly/O ./O
In/O the/O absence/O of/O E1A243/I ,/O YY1/I represses/O CRE/O -/O dependent/O transcription/O of/O c/I -/I fos/I by/O physically/O interacting/O with/O ATF/I //O CREB/I proteins/O bound/O to/O the/O -/O 67/O CRE/O ./O
Shift/O -/O down/O experiments/O indicated/O that/O the/O 10/O (/O 4/O )-/O to/O 10/O (/O 5/O )-/O fold/O reduction/O in/O virus/O yield/O at/O the/O nonpermissive/O temperature/O was/O due/O to/O the/O disfunction/O of/O alpha/I TIF/I late/O in/O infection/O ,/O presumably/O in/O virion/O maturation/O ./O
These/O results/O demonstrate/O that/O tip/I acts/O at/O an/O early/O stage/O of/O the/O T/O -/O cell/O signal/O transduction/O cascade/O by/O associating/O with/O Lck/I and/O downregulating/O Lck/O -/O mediated/O activation/O ./O
Human/I immunodeficiency/I virus/I type/I 1/I Vpr/I is/O a/O virion/O -/O associated/O ,/O regulatory/O protein/O that/O is/O required/O for/O efficient/O viral/O replication/O in/O monocytes/O //O macrophages/O ./O
Here/O we/O examine/O the/O potential/O for/O VP16/I protein/O -/O protein/O interactions/O specific/O to/O virus/O -/O infected/O cells/O and/O show/O that/O VP16/I copurifies/O in/O a/O highly/O enriched/O fraction/O with/O a/O single/O major/O polypeptide/O which/O we/O identify/O as/O the/O virus/O -/O encoded/O structural/O protein/O VP22/I ./O
Thus/O ,/O transcriptional/O regulation/O ,/O splicing/O ,/O kinase/O interaction/O sites/O ,/O and/O tyrosine/O phosphorylation/O of/O the/O LMP2A/I homologs/I have/O been/O conserved/O despite/O significant/O sequences/O heterogeneity/O in/O the/O preterminal/O repeat/O regions/O of/O these/O human/O and/O nonhuman/O primate/O EBVs/O ./O
Results/O of/O the/O ECAT/O Angina/O Pectoris/O Study/O Group/O ./O
Therefore/O ,/O a/O prospective/O Phase/O II/O trial/O was/O conducted/O to/O determine/O the/O safety/O and/O efficacy/O of/O cryosurgery/O following/O radiation/O therapy/O in/O men/O with/O local/O recurrence/O ./O
These/O motifs/O include/O a/O Chi/O motif/O and/O a/O Chi/O -/O like/O element/O previously/O found/O in/O the/O recombination/O hotspot/O region/O of/O the/O Bcl/I -/I 2/I proto/I -/I oncogene/I and/O close/O to/O chromosomal/O breakpoints/O in/O T/O -/O ALL/O lines/O ./O
Common/O history/O and/O prospects/O in/O surgical/O gynecology/O of/O the/O Charite/O and/O the/O Vienna/O University/O Clinic/O
In/O contrast/O with/O the/O previously/O reported/O HMGR1/I mRNA/I (/O HMGR1S/I mRNA/I ),/O which/O is/O detected/O at/O high/O levels/O in/O all/O tissues/O of/O the/O plant/O ,/O HMGR1L/I mRNA/I is/O present/O at/O relatively/O low/O levels/O and/O its/O expression/O is/O restricted/O mostly/O to/O seedlings/O ,/O roots/O and/O inflorescences/O ./O
However/O ,/O the/O requirement/O of/O rev3/I for/O the/O production/O of/O G/O ./O C/O -->/O T/O ./O A/O transversions/O by/O the/O rad18/I mutator/I ,/O which/O induces/O only/O these/O substitutions/O ,/O was/O similar/O to/O that/O for/O rad6/I -/O mediated/O G/O ./O C/O -->/O T/O ./O A/O transversion/O ./O
The/O second/O mutation/O present/O in/O the/O original/O mutant/O proved/O to/O be/O an/O allele/O of/O a/O known/O gene/O ,/O PBS2/I ,/O which/O encodes/O a/O putative/O protein/O kinase/O that/O functions/O in/O the/O high/O osmolarity/O stress/O pathway/O ./O
In/O adult/O tissues/O ,/O it/O was/O less/O restricted/O ,/O indicating/O that/O RAFTK/I expression/O is/O developmentally/O up/O -/O regulated/O ./O
As/O hGM/I -/I CSF/I receptor/I (/O hGMR/I )/O does/O not/O contain/O a/O consensus/O sequence/O for/O binding/O of/O PI/I 3/I -/I kinase/I ,/O hGMR/I must/O use/O a/O distinct/O mechanism/O for/O its/O association/O with/O and/O activation/O of/O PI/I 3/I -/I kinase/I ./O
J/O ./O
The/O identity/O between/O hnRNPs/I H/I and/O H/I '/I is/O 96/O %,/O between/O H/I and/O F/I 78/O %,/O and/O between/O H/I '/I and/O F/I 75/O %,/O respectively/O ./O
TPBF/I has/O two/O potential/O coiled/O -/O coil/O regions/O ,/O a/O basic/O region/O ,/O a/O proline/O -/O rich/O region/O ,/O a/O histidine/O -/O rich/O N/O terminus/O ,/O and/O a/O nuclear/O targeting/O sequence/O ./O
In/O the/O present/O study/O ,/O we/O transiently/O expressed/O in/O primary/O cultures/O of/O rat/O hepatocytes/O plasmids/O consisting/O of/O CYP3A1/I 5/I '-/I flanking/I sequences/I fused/O to/O a/O chloramphenicol/I acetyltransferase/I reporter/I plasmid/O ./O
We/O show/O that/O stimulation/O of/O resting/O splenic/O B/O cells/O with/O CD40L/I -/O expressing/O Sf9/O cells/O induces/O germ/O -/O line/O gamma/O 1/O and/O epsilon/O transcripts/O independently/O of/O cytokines/O ./O
To/O confirm/O the/O GapIII/I protein/I activity/O ,/O constructs/O containing/O different/O GapIII/I -/O GRD/I domains/O were/O transformed/O into/O iral/I mutant/O yeast/O to/O determine/O their/O relative/O ability/O to/O replace/O IRA1/I functionally/O ./O
At/O the/O time/O of/O the/O 13/O latest/O BPVs/O ,/O age/O ranged/O from/O three/O days/O to/O 13/O ./O 1/O years/O (/O mean/O 5/O ./O 7/O +/-/O SD/O 4/O ./O 8/O years/O )./O
A/O tobacco/O homologue/O (/O trolC/I )/O of/O the/O rolC/I gene/I of/I the/I Agrobacterium/I rhizogenes/I Ri/I -/I plasmid/I was/O cloned/O and/O sequenced/O from/O Nicotiana/O tabacum/O L/O ./O cv/O ./O
High/O ADR1/I gene/I dosage/O increased/O the/O transcription/O of/O genes/O encoding/O peroxisomal/O proteins/O as/O compared/O to/O one/O copy/O of/O the/O ADR1/I gene/I ./O
A/O water/O -/O vapour/O giga/O -/O maser/O in/O the/O active/O galaxy/O TXFS2226/O -/O 184/O ./O
Of/O the/O three/O known/O C/I //I EBP/I family/I inhibitors/O ,/O Ig/I //I EBP/I ,/O LIP/I and/O CHOP/I -/I 10/I ,/O only/O Ig/I //I EBP/I is/O ubiquitously/O expressed/O ./O
The/O effects/O of/O a/O 1/O -/O or/O 24/O -/O hour/O pretreatment/O regimen/O with/O monophosphoryl/O lipid/O A/O (/O MLA/O ,/O 35/O micrograms/O //O kg/O i/O ./O v/O .)/O on/O myocardial/O stunning/O produced/O by/O repetitive/O coronary/O occlusions/O were/O studied/O in/O barbital/O -/O anesthetized/O dogs/O ./O
These/O incisors/O were/O studied/O by/O scanning/O electron/O microscopy/O -/O energy/O dispersive/O spectroscopy/O analysis/O (/O SEM/O -/O EDS/O )/O and/O light/O microscopy/O to/O examine/O the/O calciotraumatic/O lines/O of/O strontium/O in/O the/O rat/O incisor/O labial/O dentin/O ./O
A/O platelet/I -/I derived/I growth/I factor/I receptor/I (/O PDGF/I -/I R/I )/O phosphopeptide/O containing/O Tyr/O -/O 857/O does/O not/O bind/O appreciably/O to/O the/O Src/I SH2/I domain/I ,/O suggesting/O it/O is/O not/O the/O PDGF/I -/I R/I binding/O site/O for/O Src/I as/O previously/O reported/O ./O
We/O have/O also/O tested/O Src/I SH2/I mutants/O for/O their/O binding/O properties/O and/O have/O interpreted/O our/O results/O in/O light/O of/O the/O recent/O crystal/O structure/O solution/O for/O the/O Src/I SH2/I domain/O ./O
These/O observations/O link/O actin/I plaque/O assembly/O to/O increased/O cell/O substrate/O adhesion/O ./O
The/O early/O lethality/O of/O the/O left/O -/O sided/O resectio/O was/O 0/O %/O and/O the/O postoperative/O survival/O --/O 5/O -/O 10/O months/O ./O
There/O are/O two/O immunogenic/O sites/O on/O the/O type/O A/O influenza/O A/O //O Japan/O //O 57/O (/O H2N2/O )/O hemagglutinin/I (/O HA/I )/O that/O can/O be/O recognized/O by/O class/I I/I major/I histocompatibility/I complex/I (/O MHC/I ),/O H/I -/I 2Kd/I -/O restricted/O cytolytic/O T/O lymphocytes/O (/O CTLs/O )./O
This/O enhancer/O activates/O both/O the/O K19/I and/O TK/I basal/I promoters/I in/O HeLa/O cells/O ./O
Mechanism/O of/O enhancement/O of/O DNA/O expression/O consequent/O to/O cointernalization/O of/O a/O replication/O -/O deficient/O adenovirus/O and/O unmodified/O plasmid/O DNA/O ./O
Interestingly/O ,/O one/O IRF/I binding/I site/I was/O found/O within/O the/O IRF/I -/I 2/I promoter/I ,/O and/O expression/O of/O the/O IRF/I -/I 2/I gene/I was/O affected/O by/O both/O transient/O and/O stable/O IRF/I -/I 1/I expression/O ./O
Therefore/O ,/O we/O studied/O ninety/O coagulopathic/O patients/O with/O the/O aim/O of/O determining/O the/O prevalence/O of/O hepatitis/I C/I virus/I (/I HCV/I )/I antibodies/I using/O the/O ELISA/O and/O RIBA/O methods/O ./O
The/O highest/O decrease/O in/O mutagenic/O activity/O was/O observed/O when/O enzymatic/O bleaching/O was/O used/O together/O with/O chlorine/O ./O
Hepatitis/I B/I surface/I antigen/I was/O detected/O in/O 2/O patients/O ,/O with/O negative/O hepatitis/I C/I virus/I antibody/I ./O
There/O was/O also/O a/O highly/O significant/O correlation/O between/O total/O selenium/O intake/O and/O liver/O selenium/O concentration/O (/O r/O =/O 0/O ./O 99/O ,/O p/O /O fibronectin/I variants/I containing/O CS1/I >>/O other/O fibronectin/I variants/I )./O
When/O expressed/O in/O and/O purified/O from/O Escherichia/O coli/O ,/O both/O full/I -/I length/I Fpr3/I and/O its/O isolated/O COOH/O -/O terminal/O domain/O exhibit/O readily/O detectable/O PPIase/I activity/O ./O
Dilutions/O of/O H/I -/I 2b/I or/I H/I -/I 2d/I NP/I peptides/I indicated/O that/O 3/O -/O 4/O logs/O less/O H/I -/I 2b/I NP/I peptide/I was/O required/O to/O sensitize/O syngeneic/O target/O cells/O for/O CTL/O -/O specific/O lysis/O ,/O suggesting/O that/O the/O differing/O affinities/O of/O H/O -/O 2b/O and/O H/O -/O 2d/O major/I histocompatibility/I complex/I molecules/I for/O their/O peptides/O likely/O account/O for/O the/O total/O removal/O of/O NP/O CTL/O in/O the/O H/O -/O 2b/O mice/O but/O only/O partial/O removal/O in/O H/O -/O 2d/O mice/O made/O to/O express/O thymic/O NP/O ./O
However/O ,/O expression/O of/O sigma/I 3/I from/O S4/I (/O 3/I '/I UTR/I //I S1/I ),/O which/O included/O the/O PKR/I activator/I sequence/I from/O S1/I within/O the/O 3/I '-/I UTR/I of/I S4/I ,/O was/O comparable/O to/O that/O from/O wild/I -/I type/I S4/I ./O
Microvessels/O were/O counted/O in/O a/O x200/O field/O (/O 0/O ./O 754/O mm2/O )/O in/O the/O area/O of/O maximal/O angiogenesis/O ./O
Although/O both/O transfected/O cell/O lines/O contain/O FGF/I -/I 1/I cell/I surface/I receptors/I as/O judged/O by/O crosslinking/O studies/O ,/O the/O wild/O -/O type/O transfectants/O are/O refractory/O to/O exogenous/O FGF/I -/I 1/I ,/O whereas/O the/O mutant/O transfectants/O respond/O normally/O .(/O ABSTRACT/O TRUNCATED/O AT/O 250/O WORDS/O )/O
Recent/O studies/O have/O demonstrated/O that/O the/O activated/O GH/I receptor/I can/O stimulate/O Stat1/I ,/O a/O cytoplasmic/O transcription/O factor/O that/O becomes/O tyrosine/O phosphorylated/O and/O translocates/O to/O the/O nucleus/O ,/O where/O it/O can/O interact/O with/O specific/O DNA/O sequences/O to/O modulate/O gene/O expression/O ./O
In/O viral/O infections/O ,/O G/I -/I CSF/I was/O correlated/O with/O mononuclear/O cells/O (/O rs/O =/O 0/O ./O 41/O ,/O P/O /O 33/O kilobases/O )/O contains/O seven/O exons/O ,/O all/O of/O which/O have/O homologues/O at/O the/O corresponding/O position/O in/O the/O alpha/I 1/I -/I syntrophin/I gene/I ./O
Altogether/O our/O data/O indicate/O that/O PEDF/I belongs/O to/O the/O subgroup/O of/O noninhibitory/O serpins/I and/O that/O its/O N/O -/O terminal/O region/O confers/O a/O neurite/O -/O promoting/O activity/O to/O the/O protein/O ./O
We/O report/O here/O the/O cloning/O of/O the/O murine/O p44/I MAP/I kinase/I (/O extracellular/I signal/I -/I regulated/I kinase/I 1/I )/O gene/O ,/O the/O determination/O of/O its/O intron/O //O exon/O boundaries/O ,/O and/O the/O characterization/O of/O its/O promoter/O ./O
It/O contains/O three/O putative/O TATA/O boxes/O far/O upstream/O of/O the/O main/O start/O sites/O region/O ,/O one/O AP/I -/I 1/I box/I ,/O one/O AP/I -/I 2/I box/I ,/O one/O Malt/I box/I ,/O one/O GAGA/O box/O ,/O one/O half/O serum/O -/O responsive/O element/O ,/O and/O putative/O binding/O sites/O for/O Sp1/I (/O five/O ),/O GC/I -/I rich/I binding/I factor/I (/O five/O ),/O CTF/I -/I NF1/I (/O one/O ),/O Myb/I (/O one/O ),/O p53/I (/O two/O ),/O Ets/I -/I 1/I (/O one/O ),/O NF/I -/I IL6/I (/O two/O ),/O MyoD/I (/O two/O ),/O Zeste/I (/O one/O ),/O and/O hepatocyte/I nuclear/I factor/I -/I 5/I (/O one/O )./O
One/O of/O these/O is/O surrounded/O by/O an/O adenine/O -/O uridine/O rich/O region/O that/O can/O form/O an/O 11/O -/O base/O pair/O stem/O structure/O ./O
We/O conclude/O that/O this/O new/O measurement/O technique/O provides/O an/O easy/O and/O accurate/O P0/O ./O 1/O measurement/O using/O standard/O respiratory/O equipment/O when/O tested/O in/O a/O lung/O model/O ./O
Effects/O of/O verapamil/O and/O propranolol/O on/O early/O afterdepolarizations/O and/O ventricular/O arrhythmias/O induced/O by/O epinephrine/O in/O congenital/O long/O QT/O syndrome/O ./O
Deletion/O of/O the/O NF/I -/I IL6/I beta/I leucine/I zipper/I domain/I also/O greatly/O diminished/O the/O interaction/O between/O these/O two/O proteins/O ./O
After/O cells/O were/O stably/O transfected/O with/O CIITA/I ,/O endogenous/O MHC/I class/I II/I genes/I were/O constitutively/O expressed/O ,/O and/O MHC/I class/I II/I promoters/I ,/O delivered/O by/O transfection/O ,/O were/O actively/O transcribed/O in/O CIITA/I -/O expressing/O cells/O ./O
Two/O domains/O of/O EBNA2/I defined/O by/O deletion/O of/O amino/O acids/O 247/O -/O 337/O and/O 437/O -/O 476/O were/O found/O to/O be/O important/O for/O the/O activation/O of/O both/O promoters/O ,/O while/O two/O different/O domains/O corresponding/O to/O residues/O 4/O -/O 18/O and/O 118/O -/O 198/O were/O required/O solely/O for/O the/O LMP1/I promoter/I ./O
The/O peak/O velocities/O of/O the/O atrial/O systolic/O waves/O of/O the/O transmitral/O and/O pulmonary/O venous/O flow/O velocities/O (/O A/O and/O PVA/O ,/O respectively/O )/O and/O first/O systolic/O wave/O (/O PVS1/O )/O of/O pulmonary/O venous/O flow/O ,/O durations/O of/O both/O atrial/O systolic/O waves/O ,/O and/O amplitude/O of/O interatrial/O septal/O motion/O during/O atrial/O systole/O increased/O significantly/O ten/O days/O after/O cardioversion/O compared/O with/O those/O measured/O within/O a/O day/O of/O cardioversion/O in/O all/O patients/O except/O the/O 5/O patients/O with/O dilated/O cardiomyopathy/O ./O
Additionally/O ,/O the/O enzyme/O shows/O activity/O towards/O triglycerides/O such/O as/O olive/O oil/O and/O tributyrin/O and/O towards/O egg/O -/O yolk/O emulsions/O ./O
The/O nucleotide/O sequence/O directly/O upstream/O of/O fimA/I contains/O two/O open/O reading/O frames/O ,/O ORF5/O and/O ORF1/O ,/O whose/O deduced/O protein/O products/O are/O homologous/O to/O members/O of/O a/O superfamily/O of/O ATP/I -/I binding/I cassette/I membrane/I transport/I proteins/I ,/O including/O both/O prokaryotic/O and/O eukaryotic/O uptake/O and/O export/O systems/O ./O
The/O ORF3/O probe/O also/O hybridized/O to/O a/O 540/O bp/O transcript/O consistent/O with/O the/O size/O of/O ORF3/O alone/O and/O supportive/O of/O the/O mutagenesis/O data/O of/O non/O -/O linkage/O ./O
These/O results/O suggest/O that/O low/O concentrations/O of/O IL/I -/I 1/I beta/I may/O be/O useful/O for/O nonsurgical/O treatment/O of/O human/O vitreous/O hemorrhage/O ./O
We/O conclude/O that/O pancreatic/O polypeptide/O and/O motilin/I responses/O to/O a/O meal/O are/O different/O in/O encopretic/O children/O than/O in/O children/O in/O the/O control/O group/O ./O
Here/O we/O report/O the/O cloning/O ,/O expression/O ,/O and/O biochemical/O characterization/O of/O the/O 32/O -/O kDa/O subunit/O of/O human/O (/O h/O )/O TFIID/I ,/O termed/O hTAFII32/I ./O
Hemolytic/O jaundice/O due/O to/O G6PD/I deficiency/O causing/O kernicterus/O in/O a/O female/O newborn/O ./O
Two/O transcripts/O of/O 1/O ./O 6/O kb/O and/O 5/O ./O 8/O kb/O are/O 5/O '/O coterminal/O and/O may/O both/O encode/O the/O novel/O glycoprotein/I gene/I EUS4/I ./O
Mean/O growth/O changes/O in/O this/O Class/O II/O sample/O were/O comparable/O to/O those/O previously/O reported/O for/O male/O subjects/O with/O Class/O I/O malocclusions/O over/O the/O same/O age/O period/O ,/O suggesting/O a/O similarity/O in/O postpubertal/O development/O between/O these/O two/O groups/O ./O
However/O ,/O the/O few/O studies/O that/O address/O antimicrobial/O prophylaxis/O in/O bone/O marrow/O transplantation/O have/O not/O always/O shown/O a/O survival/O benefit/O ./O
The/O fracture/O groups/O were/O significantly/O older/O and/O had/O more/O years/O since/O menopause/O than/O the/O control/O groups/O ./O
In/O addition/O ,/O we/O found/O differences/O in/O the/O binding/O of/O nuclear/O factors/O from/O shoots/O versus/O from/O roots/O ,/O in/O agreement/O with/O the/O different/O activities/O of/O the/O promoter/O in/O these/O two/O organs/O ./O
The/O prevalence/O and/O incidence/O of/O human/O immunodeficiency/O virus/O types/O 1/O and/O 2/O (/O HIV/O -/O 1/O ,/O HIV/O -/O 2/O ),/O human/O T/O -/O lymphotropic/O virus/O types/O I/O and/O II/O (/O HTLV/O -/O I/O //O II/O ),/O and/O syphilitic/O infections/O and/O the/O association/O between/O these/O infections/O were/O determined/O in/O a/O cohort/O of/O police/O officers/O in/O Guinea/O -/O Bissau/O ./O
By/O in/O vitro/O immunoprecipitations/O and/O gel/O shift/O assays/O ,/O we/O identified/O two/O classes/O of/O high/O affinity/O Engrailed/I -/I binding/I sites/I upstream/O of/O each/O of/O the/O two/O polyhomeotic/O transcription/O units/O ./O
Subjects/O with/O a/O short/O postexposure/O time/O and/O a/O dioxin/O burden/O >/O 0/O ./O 6/O pg/O //O m3/O had/O a/O significantly/O higher/O risk/O of/O hypoergy/O than/O unexposed/O subjects/O (/O hypoergy/O I/O :/O OR/O =/O 9/O ./O 51/O ,/O 95/O %/O CI/O =/O 1/O ./O 96/O -/O 42/O ./O 02/O ;/O hypoergy/O II/O :/O OR/O =/O 2/O ./O 92/O ,/O 95/O %/O CI/O =/O 1/O ./O 14/O -/O 7/O ./O 5/O )./O
Analysis/O of/O this/O sequence/O combined/O with/O that/O previously/O reported/O for/O the/O 5/O '-/O flanking/O region/O directly/O proximal/O to/O the/O start/O of/O transcription/O revealed/O several/O putative/O regulatory/O sequences/O ./O
We/O now/O show/O that/O the/O BAT1/I translation/I product/I is/O the/O homolog/O of/O the/O rat/I p47/I nuclear/I protein/I ,/O the/O WM6/I Drosophila/I gene/I product/I ,/O and/O probably/O also/O Ce08102/I of/O Caenorhabditis/O elegans/O ,/O all/O members/O of/O the/O DEAD/I protein/I family/I of/O ATP/I -/I dependent/I RNA/I helicases/I ./O
By/O using/O lacZ/I fusions/I ,/O it/O was/O possible/O to/O localize/O the/O DNA/O sequences/O required/O to/O mediate/O nitrate/O repression/O to/O the/O pfl/I promoter/I -/I regulatory/I region/I ./O
In/O this/O report/O ,/O we/O describe/O the/O characterization/O of/O two/O early/O class/I II/I flagellar/I genes/I contained/O in/O the/O orfX/O -/O fliP/I locus/O ./O
Vestibular/O adaptation/O exercises/O and/O recovery/O :/O acute/O stage/O after/O acoustic/O neuroma/O resection/O ./O
The/O experimental/O design/O represents/O a/O 2/O x/O 3/O factorial/O arrangement/O of/O treatments/O with/O three/O dietary/O levels/O of/O incorporation/O of/O RSB/O (/O 0/O ,/O 50/O ,/O and/O 100/O %),/O and/O chickens/O either/O infected/O or/O uninfected/O ./O
A/O cDNA/O clone/O corresponding/O to/O the/O putative/O GA/I 20/I -/O oxidase/I genomic/O sequence/O was/O constructed/O with/O the/O reverse/O transcription/O -/O PCR/O method/O ,/O and/O the/O identity/O of/O the/O cDNA/O clone/O was/O confirmed/O by/O analyzing/O the/O capability/O of/O the/O fusion/O protein/O expressed/O in/O Escherichia/O coli/O to/O convert/O GA53/I to/O GA44/I and/O GA19/I to/O GA20/I ./O
There/O were/O no/O significant/O changes/O in/O either/O the/O fatty/O acid/O composition/O of/O biliary/O lecithin/O or/O in/O the/O bile/O acid/O composition/O of/O bile/O ./O
Total/O cholesterol/O was/O also/O reduced/O at/O week/O 12/O by/O 17/O ./O 0/O %/O (/O 20/O mg/O //O day/O )/O and/O 15/O ./O 7/O %/O (/O 20/O -/O 30/O mg/O //O day/O ),/O and/O at/O week/O 52/O by/O 20/O ./O 4/O %/O (/O or/O =/O 30/O mg/O //O day/O )./O
Although/O further/O studies/O are/O required/O to/O determine/O the/O precise/O role/O of/O PEBP2/I in/O the/O GM/I -/I CSF/I promoter/I activity/O ,/O the/O present/O findings/O suggested/O the/O importance/O of/O the/O relative/O ratio/O of/O different/O PEBP2/I isoforms/I in/O regulating/O the/O levels/O of/O the/O promoter/O activity/O ./O
Benefits/O of/O obtaining/O board/O certification/O in/O pharmacotherapy/O ./O
Piperacillin/O -/O tazobactam/O can/O be/O used/O for/O the/O treatment/O of/O infections/O caused/O by/O gram/O -/O negative/O ,/O gram/O -/O positive/O ,/O aerobic/O ,/O and/O anaerobic/O bacteria/O ./O
Basal/O plasma/O renin/I activity/O (/O PRA/O )/O was/O slightly/O raised/O prior/O to/O training/O (/O P/O /O Ala/O mutant/O form/O of/O yeast/O eIF/I -/I 2/I alpha/I was/O found/O to/O be/O no/O longer/O phosphorylated/O by/O either/O of/O the/O yeast/O (/O or/O mammalian/O )/O casein/I kinase/I activities/O in/O vitro/O ./O
The/O cases/O included/O 35/O de/O novo/O diffuse/O aggressive/O lymphomas/O (/O DAL/O ;/O 19/O large/O -/O cell/O ,/O 4/O mixed/O -/O cell/O ,/O and/O 12/O large/O -/O cell/O immunoblastic/O ),/O 52/O transformed/O aggressive/O lymphomas/O derived/O from/O follicular/O lymphomas/O (/O TFL/O ),/O 42/O indolent/O follicular/O lymphomas/O (/O FL/O ),/O 14/O mantle/O cell/O lymphomas/O (/O MCL/O ),/O and/O 27/O small/O noncleaved/O cell/O lymphomas/O (/O SNCL/O )./O
Icterus/O and/O beta/O -/O thalassemia/O in/O Congolese/O children/O in/O Brazzaville/O
Female/O patients/O with/O breast/O cancer/O diagnosed/O between/O 1982/O and/O 1991/O at/O Roswell/O Park/O Cancer/O Institute/O (/O RPCI/O )/O in/O Buffalo/O ,/O New/O York/O ,/O who/O provided/O information/O on/O their/O cigarette/O smoking/O history/O at/O the/O time/O of/O their/O diagnosis/O were/O included/O ./O
Upon/O analysis/O of/O the/O tissue/O distribution/O of/O AAMP/I ,/O it/O was/O found/O to/O be/O expressed/O strongly/O in/O endothelial/O cells/O ,/O cytotrophoblasts/O ,/O and/O poorly/O differentiated/O colon/O adenocarcinoma/O cells/O found/O in/O lymphatics/O ./O
Data/O from/O the/O V/O -/O HeFT/O II/O show/O that/O at/O 2/O -/O year/O follow/O -/O up/O ,/O a/O progressive/O rise/O of/O plasma/O norepinephrine/O was/O observed/O in/O both/O treatment/O arms/O ,/O suggesting/O that/O disease/O progresses/O despite/O treatment/O with/O either/O an/O angiotensin/I -/I converting/I enzyme/I inhibitor/O ,/O enalapril/O ,/O or/O vasodilator/O therapy/O with/O hydralazine/O //O isosorbide/O dinitrate/O ./O
Binding/O activity/O in/O rat/O liver/O nuclear/O extracts/O includes/O these/O orphan/O receptors/O as/O judged/O from/O electromobility/O supershift/O experiments/O and/O from/O results/O obtained/O with/O expressed/O receptors/O ,/O although/O the/O element/O in/O CYP2C11/I did/O not/O bind/O HNF/I -/I 4/I ./O
Transcript/O analysis/O reveals/O that/O lethal/O B/I block/I substitutions/O reduce/O U6/I RNA/I synthesis/O at/O least/O 10/O -/O fold/O in/O vivo/O and/O 20/O -/O fold/O in/O vitro/O ./O
Analysis/O of/O Bcl/I -/I 2/I //O Bcl/I -/I 2/I homodimerization/O using/O both/O in/O vitro/O binding/O assays/O as/O well/O as/O a/O yeast/O two/O -/O hybrid/O method/O provided/O evidence/O in/O support/O of/O a/O head/O -/O to/O -/O tail/O model/O for/O Bcl/I -/I 2/I //O Bcl/I -/I 2/I homodimerization/O and/O revealed/O that/O sequences/O within/O the/O NH2/O -/O terminal/O A/O domain/O interact/O with/O a/O structure/O that/O requires/O the/O presence/O of/O both/O the/O carboxyl/O B/O and/O C/O domains/O in/O combination/O ./O
The/O protein/O is/O composed/O of/O a/O central/O alpha/O -/O helical/O portion/O with/O globular/O domains/O at/O both/O NH2/O and/O COOH/O termini/O ,/O and/O the/O epitope/O to/O the/O monoclonal/O antibody/O resides/O in/O the/O central/O alpha/O -/O helical/O stalk/O ./O
Radioligand/O binding/O was/O indistinguishable/O for/O both/O transiently/O expressed/O constructs/O ./O
Diagnosis/O of/O FHCS/O has/O been/O weighed/O upon/O laparoscopic/O findings/O ./O
Human/I papillomavirus/I type/I 31b/I late/I gene/I expression/O is/O regulated/O through/O protein/I kinase/I C/I -/O mediated/O changes/O in/O RNA/O processing/O ./O
Interestingly/O ,/O virions/O also/O contained/O smaller/O proteins/O that/O reacted/O with/O antibodies/O specific/O for/O the/O accessory/O proteins/O as/O well/O as/O SN/I and/O CAT/I fusion/I partners/O ./O
Studies/O using/O an/O inhibitor/O or/O a/O mutant/I Lb/I proteinase/I indicated/O that/O stimulation/O of/O IRES/O -/O driven/O translation/O is/O mediated/O via/O proteolysis/O of/O some/O cellular/O component/O (/O s/O )./O
Restriction/O mapping/O analysis/O localized/O this/O cDNA/O to/O the/O HHV/I -/I 6A/I (/I U1102/I )/I genomic/I BamHI/I G/I fragment/I ,/O at/O the/O right/O end/O of/O the/O unique/O long/O segment/O of/O the/O genome/O and/O to/O the/O SalI/I L/I and/O SalI/I O/I fragments/I within/O the/O left/O and/O right/O terminal/O direct/O repeat/O regions/O ,/O respectively/O ./O
For/O replication/O reporter/O constructs/O where/O E1/I and/O E2/I are/O supplied/O in/O trans/O by/O the/O respective/O expression/O vectors/O ,/O distance/O between/O the/O half/O sites/O seems/O to/O play/O a/O major/O role/O ,/O yet/O the/O phasing/O relationships/O are/O measurable/O ./O
As/O it/O had/O been/O previously/O reported/O that/O the/O 18/O -/O bp/O palindrome/O contains/O sufficient/O nucleotide/O sequence/O information/O for/O E1/I binding/O ,/O we/O speculate/O that/O a/O minimal/O E1/I recognition/O motif/O is/O presented/O in/O each/O half/O site/O ./O
METHODS/O :/O Out/O of/O 171/O patients/O receiving/O anticoagulation/O between/O July/O 1992/O and/O December/O 1993/O ,/O 83/O patients/O with/O hemispheric/O embolisms/O received/O heparin/O within/O 72/O hours/O from/O onset/O (/O activated/O partial/O thromboplastin/I time/O [/O aPTT/O ]/O 1/O ./O 5/O times/O control/O value/O )./O
In/O the/O commercially/O available/O intravenous/O formulation/O of/O Cyclosporin/O A/O (/O Sandimmun/O ),/O polyoxyethylated/O castor/O oil/O (/O Cremophor/O EL/O )/O is/O used/O as/O a/O solubilizing/O agent/O ./O
Lung/O function/O tests/O (/O EFR/O )/O were/O performed/O on/O these/O patients/O for/O a/O period/O of/O 19/O ./O 2/O +/-/O 3/O ./O 4/O months/O ./O
Sequence/O comparisons/O of/O prokaryotic/I RCR/I initiators/I has/O revealed/O a/O set/O of/O three/O common/O motifs/O ,/O two/O of/O which/O ,/O a/O putative/O metal/O coordination/O site/O and/O a/O downstream/O active/O -/O site/O tyrosine/O motif/O ,/O could/O be/O tentatively/O identified/O in/O parvoviral/I replicator/I proteins/I ./O
The/O mean/O marginal/O discrepancy/O of/O provisional/O restorations/O was/O compared/O for/O restorations/O fabricated/O from/O stone/O ,/O low/O -/O viscosity/O poly/O (/O vinyl/O siloxane/O ),/O and/O medium/O -/O viscosity/O poly/O (/O vinyl/O siloxane/O )./O
The/O characterized/O Aplysia/I Afurin2/I is/O a/O candidate/O PC/I that/O may/O play/O an/O important/O role/O in/O the/O processing/O of/O egg/I -/I laying/I hormone/I (/O ELH/I )-/O related/O precursors/O in/O the/O secretory/O cells/O of/O the/O atrial/O gland/O ./O
Rats/O treated/O with/O 8/O -/O OH/O -/O DPAT/O were/O not/O impaired/O in/O their/O ability/O to/O learn/O a/O visual/O discrimination/O in/O a/O water/O maze/O ./O
The/O term/O endovascular/O papillary/O haemangioma/O is/O suggested/O ./O
In/O addition/O ,/O two/O internal/O promoters/O ,/O PmiaA/I and/O P1hfq/I were/O identified/O and/O mapped/O to/O 201/O and/O 837/O nucleotides/O upstream/O from/O the/O respective/O translation/O start/O sites/O ./O
These/O results/O indicate/O that/O mutL/I ,/O miaA/I ,/O and/O hfq/I expression/O could/O be/O regulated/O by/O multiple/O mechanisms/O ,/O including/O degree/O of/O cotranscription/O from/O upstream/O genes/O ,/O modulation/O of/O internal/O promoter/O strength/O ,/O and/O by/O RNase/I E/I activity/O ./O
Coronary/O T1/O and/O T2/O weighted/O images/O were/O obtained/O ./O
The/O 2/O kb/O of/O 5/O '-/O flanking/O region/O and/O the/O 1/O ./O 1/O kb/O of/O the/O entire/O sGTH/I alpha/I subunit/I coding/O region/O were/O sequenced/O from/O the/O genomic/O clone/O ,/O sGTH/I alpha/I -/I G1/I ./O
Functional/O analysis/O of/O the/O sGTH/I alpha/I subunit/I promoter/I by/O the/O transient/O transfection/O of/O several/O sGTH/I alpha/I //O CAT/I chimeric/O plasmids/O into/O rainbow/O trout/O pituitary/O cells/O suggests/O that/O its/O pituitary/O -/O specific/O expression/O is/O GSE/I -/O dependent/O ./O
Indium/O -/O 111/O OncoScint/O CR/O //O OV/O and/O F/O -/O 18/O FDG/O in/O colorectal/O and/O ovarian/O carcinoma/O recurrences/O ./O
His/O carnitine/I palmitoyltransferase/I (/I CPT/I )/I I/I and/I II/I activities/O were/O 0/O ./O 06/O and/O 0/O ./O 12/O nmol/O //O min/O //O mg/O protein/O ,/O as/O compared/O with/O a/O mean/O value/O of/O 0/O ./O 22/O +/-/O 0/O ./O 14/O and/O 0/O ./O 27/O +/-/O 0/O ./O 07/O nmol/O //O min/O //O mg/O protein/O ,/O respectively/O ,/O in/O control/O subjects/O ./O
The/O Myc/I LZ/I was/O found/O to/O prevent/O homodimeric/O interactions/O ,/O thus/O explaining/O Myc/I inability/O to/O homodimerize/O efficiently/O ./O
Staphylococcus/O aureus/O and/O CNS/O showed/O high/O or/O moderate/O resistance/O rates/O to/O methicillin/O (/O DMPPC/O )./O
Thus/O ,/O VF/O resistant/O to/O defibrillation/O is/O not/O necessarily/O associated/O with/O both/O toxic/O plasma/O drug/O level/O and/O remarkably/O decreased/O conduction/O ./O
The/O smallest/O active/I FecR/I derivative/I contained/O 59/O amino/O acid/O residues/O as/O compared/O to/O the/O 317/O residues/O of/O wild/I -/I type/I FecR/I ./O
The/O gene/O pairs/O psbB/I -/O psbT/I and/O psbH/I -/O psbN/I are/O cotranscribed/O from/O opposite/O strands/O ./O
Hybridization/O signals/O were/O also/O detected/O with/O total/O DNAs/O of/O Rhizobium/O leguminosarum/O bv/O ./O phaseoli/O ,/O Rhodobacter/O capsulatus/O and/O Escherichia/O coli/O ,/O but/O not/O those/O of/O Xanthomonas/O campestris/O pv/O ./O campestris/O and/O Pseudomonas/O putida/O ./O
The/O predicted/O amino/O acid/O sequence/O contains/O regions/O identical/O to/O the/O sequences/O of/O peptides/O derived/O from/O bovine/I liver/I eIF/I -/I 2B/I alpha/I subunit/I ./O
Expression/O of/O this/O cDNA/O in/O vitro/O yields/O a/O peptide/O which/O comigrates/O with/O natural/I eIF/I -/I 2B/I alpha/I in/O SDS/O //O polyacrylamide/O gels/O ./O
When/O RNA/O encoding/O the/O tail/O domain/O of/O desmoglein/I was/O coinjected/O with/O plakoglobin/I RNA/I ,/O both/O the/O dorsalizing/O effect/O and/O nuclear/O accumulation/O of/O plakoglobin/I were/O suppressed/O ./O
Six/O of/O them/O ,/O NUC1/I ,/O PRP21/I (/O also/O called/O SPP91/I ),/O CDC6/I ,/O CRY2/I ,/O the/O gene/O encoding/O the/O ribosomal/I protein/I S24/I and/O the/O gene/O coding/O for/O a/O hypothetical/O protein/O of/O 599/O amino/O acids/O ,/O have/O been/O sequenced/O previously/O ./O
Intrastriatal/O grafts/O of/O nigral/O and/O adrenal/O tissues/O have/O been/O found/O to/O be/O effective/O in/O alleviating/O many/O of/O the/O simple/O motor/O and/O sensorimotor/O deficits/O associated/O with/O lesions/O of/O the/O nigrostriatal/O dopamine/O system/O ./O
OBJECTIVE/O :/O To/O determine/O the/O impact/O of/O the/O introduction/O of/O clarithromycin/O and/O azithromycin/O on/O the/O treatment/O and/O survival/O of/O patients/O with/O AIDS/O and/O disseminated/O Mycobacterium/O avium/O complex/O (/O DMAC/O )./O
Thereafter/O ,/O the/O aggregation/O rose/O to/O the/O initial/O 100/O %/O value/O 4/O h/O after/O drug/O application/O and/O remained/O at/O this/O level/O during/O the/O observation/O period/O .(/O ABSTRACT/O TRUNCATED/O AT/O 250/O WORDS/O )/O
Growth/O curves/O indicated/O that/O proliferation/O of/O clone/O CA9/O in/O the/O presence/O of/O 10/O %/O serum/O was/O reduced/O by/O 60/O %/O compared/O with/O clone/O ME10/O ./O
The/O protein/O coding/O region/O ,/O 1/O ,/O 696/O bps/O long/O ,/O is/O divided/O by/O an/O intron/O into/O two/O exons/O ./O
The/O UAS/O of/O the/O AAC2/I gene/I contains/O at/O least/O two/O distinct/O motifs/O for/O DNA/O -/O binding/O transcriptional/O activators/O ,/O including/O one/O which/O is/O identical/O with/O the/O core/O HAP2/I //I 3/I //I 4/I binding/I motif/I ,/O and/O a/O second/O one/O with/O the/O ABF1/I consensus/I binding/I sequence/I ./O
The/O emerging/O complexity/O of/O the/O 5/O '/O regulatory/O region/O of/O the/O GH/I receptor/I gene/I was/O emphasised/O by/O the/O observation/O that/O probes/O derived/O from/O exon/O 1B/O and/O the/O distal/O 3/O '/O intron/O boundary/O do/O not/O hybridise/O with/O previously/O cloned/O genomic/O sequences/O that/O span/O the/O liver/O -/O specific/O P1/O promoter/O and/O exon/O 2/O ./O
A/O polymorphic/O dinucleotide/O (/O GT/O //O CA/O )/O n/O repeat/O contained/O in/O the/O NHE5/O cosmid/O was/O identified/O and/O developed/O into/O a/O microsatellite/O PCR/O marker/O ./O
The/O proteins/O are/O more/O than/O 90/O %/O identical/O to/O each/O other/O within/O the/O protein/O kinase/O domain/O but/O only/O 51/O -/O 59/O %/O identical/O to/O other/O casein/I kinase/I I/I isoforms/I within/O this/O region/O ./O
We/O used/O two/O approaches/O to/O ascertain/O whether/O CDP/I //O cut/I serves/O as/O a/O repressor/O of/O gp91/I -/O phox/I gene/O expression/O ./O
Serum/O induction/O of/O a/O MEF2/I reporter/I gene/I was/O not/O observed/O in/O a/O line/O of/O NIH/O 3T3/O cells/O which/O contain/O low/O MEF2/I site/I binding/O activity/O ./O
Despite/O the/O activation/O of/O these/O intracellular/O signaling/O molecules/O ,/O PDGF/I beta/I receptor/I activation/O elicited/O no/O detectable/O effect/O on/O cell/O proliferation/O or/O differentiation/O ./O
UAS1/O is/O the/O binding/O site/O for/O the/O transcriptional/O regulator/O Adr1p/I ./O
In/O the/O context/O of/O the/O ADH2/I upstream/I regulatory/I region/I ,/O including/O UAS1/O ,/O working/O in/O concert/O with/O the/O ADH2/I basal/I promoter/I elements/I ,/O UAS2/O -/O dependent/O gene/O activation/O was/O dependent/O on/O orientation/O ,/O copy/O number/O ,/O and/O helix/O phase/O ./O
Induction/O in/O AP/I -/I 1/I DNA/O binding/O correlates/O with/O a/O concomitant/O GH/I trans/O -/O activation/O of/O c/I -/I jun/I and/O c/I -/I fos/I genes/I described/O previously/O ./O
Inactivation/O of/O MAP/I kinases/I occurs/O via/O a/O specific/O phosphatase/O ,/O MKP/I -/I 1/I ./O
Short/O -/O course/O amphotericin/O B/O therapy/O for/O candidemia/O in/O pediatric/O patients/O ./O
Furthermore/O ,/O 45Ca/O -/O binding/O assays/O revealed/O that/O CCaMK/I directly/O binds/O Ca2/O +./O
Since/O AP/I -/I 1/I is/O an/O important/O mediator/O of/O tumor/O promoter/O action/O ,/O these/O findings/O may/O explain/O the/O anti/O -/O tumor/O -/O promoting/O activity/O of/O phenolic/O antioxidants/O ./O
The/O second/O complex/O ,/O when/O purified/O ,/O contained/O four/O protein/O components/O including/O the/O 36/O -/O kDa/O protein/O ./O
The/O protein/O expressed/O from/O the/O cloned/O cDNA/O is/O secreted/O into/O the/O culture/O medium/O and/O yields/O of/O up/O to/O 40/O mg/O per/O litre/O have/O been/O obtained/O ./O
The/O study/O was/O repeated/O after/O administration/O of/O oral/O amiodarone/O ,/O 50/O mg/O //O kg/O //O day/O for/O 2/O days/O in/O 8/O divided/O doses/O (/O mean/O dose/O 6/O ./O 9/O +/-/O 0/O ./O 4/O g/O )./O
Plasmids/O pAMS12/O ,/O pAMS13/O and/O pAMS14/O were/O transformed/O into/O a/O laboratory/O strain/O of/O Saccharomyces/O cerevisiae/O ,/O whereas/O pAMS15/O was/O stably/O introduced/O into/O two/O commercial/O wine/O yeast/O strains/O ./O
The/O maximum/O induction/O of/O ACC/I -/I oxidase/I transcripts/I occurred/O at/O about/O 6/O h/O after/O excision/O ,/O while/O the/O maximum/O enzyme/O activity/O was/O observed/O at/O 24/O h/O ./O
Within/O their/O polypeptide/O chain/O ,/O they/O all/O contain/O those/O conserved/O features/O that/O define/O a/O plant/O CDPK/I ;/O kinase/O catalytic/O sequences/O are/O linked/O to/O a/O calmodulin/I -/I like/I regulatory/I domain/I through/O a/O junction/O region/O ./O
Repair/O of/O this/O insertion/O by/O homologous/O recombination/O restores/O the/O activity/O of/O the/O hprt/I locus/I ,/O thus/O confirming/O the/O site/O of/O mutation/O ./O
The/O timing/O of/O fla/I gene/I expression/O in/O the/O cell/O cycle/O is/O determined/O by/O specialized/O forms/O of/O RNA/I polymerase/I and/O the/O appearance/O and/O //O or/O activation/O of/O regulatory/O proteins/O ./O
Primer/O extension/O experiments/O revealed/O a/O strong/O transcription/O initiation/O site/O 102/O bp/O upstream/O of/O the/O translational/O start/O site/O ./O
Polypeptides/O of/O the/O same/O apparent/O sizes/O are/O detected/O in/O spores/O of/O a/O cotE/I null/O mutant/O ,/O on/O which/O basis/O we/O infer/O that/O the/O products/O of/O the/O cotJ/I operon/I are/O required/O for/O the/O normal/O formation/O of/O the/O inner/O layers/O of/O the/O coat/O or/O are/O themselves/O structural/O components/O of/O the/O coat/O ./O
Based/O on/O the/O estimated/O values/O of/O divergence/O of/O apobec1/I sequences/I in/O terms/O of/O the/O numbers/O of/O synonymous/O and/O non/O -/O synonymous/O suhstitutions/O per/O site/O ,/O we/O found/O that/O apobec1/I is/O a/O fairly/O rapidly/O evolving/O protein/O ./O
EEA1/I is/O a/O conserved/O alpha/O -/O helical/O peripheral/O membrane/O protein/O flanked/O by/O cysteine/O "/O fingers/O "/O and/O contains/O a/O calmodulin/I -/I binding/I IQ/I motif/I ./O
Nucleotide/O sequences/O of/O the/O clones/O revealed/O that/O one/O clone/O ,/O cap3/I ,/O contained/O an/O open/O reading/O frame/O (/O ORF/O )/O that/O would/O code/O for/O a/O 26/O -/O amino/O acid/O ,/O cysteine/O -/O rich/O peptide/O with/O significant/O homology/O to/O Neurospora/I crassa/I copper/I metallothionein/I ./O
Sensing/O with/O chemically/O and/O biologically/O modified/O carbon/O electrodes/O ./O
Elevation/O of/O the/O tissues/O of/O the/O face/O is/O essentially/O vertical/O and/O acts/O on/O the/O forehead/O ,/O temporal/O region/O ,/O gaze/O and/O cheekbones/O ./O
This/O region/O binds/O two/O ubiquitous/O nuclear/O factors/O ,/O USF/I //O MLTF/I and/O the/O CAAT/I -/I binding/I transcription/I factor/I //O nuclear/I factor/I 1/I (/O CTF/I //O NF1/I )./O
The/O potential/O impact/O of/O using/O a/O rapid/O diagnostic/O test/O (/O Strep/O A/O OIA/O )/O on/O detection/O and/O treatment/O of/O group/O A/O beta/O -/O hemolytic/O streptococcal/O (/O GABHS/O )/O pharyngitis/O in/O a/O large/O -/O volume/O pediatric/O and/O adolescent/O clinic/O was/O examined/O ./O
The/O bHLH/I proteins/I function/O as/O potent/O transcriptional/O activators/O of/O tissue/O -/O specific/O genes/O by/O forming/O heterodimers/O between/O ubiquitous/O and/O cell/O -/O restricted/O family/O members/O ./O
YAC/O and/O cosmid/O contigs/O spanning/O the/O BRCA1/I region/I were/O used/O to/O select/O cDNA/O clones/O from/O pools/O of/O cDNAs/O derived/O from/O human/O placenta/O ,/O HeLa/O cells/O ,/O activated/O T/O cells/O ,/O and/O fetal/O head/O ./O
The/O other/O two/O clones/O ,/O Ash/I -/I m/I and/I -/I s/I ,/O had/O nucleotide/O sequences/O identical/O with/O Ash/I -/I l/I cDNA/O in/O the/O amino/O -/O terminal/O region/O ./O
This/O study/O assesses/O the/O feasibility/O and/O toxicity/O of/O adoptive/O immunotherapy/O with/O tumor/O infiltrating/O lymphocytes/O and/O recombinant/I interleukin/I -/I 2/I in/O 29/O patients/O who/O underwent/O resection/O for/O stage/O III/O non/O -/O small/O -/O cell/O lung/O cancer/O ./O
MATERIAL/O AND/O METHODS/O :/O Of/O the/O 17/O men/O and/O 17/O women/O ,/O who/O were/O 21/O to/O 80/O years/O of/O age/O ,/O 27/O had/O hereditary/O motor/O and/O sensory/O neuropathy/O type/O I/O and/O 7/O had/O acquired/O demyelinating/O polyneuropathy/O ./O
The/O present/O study/O describes/O the/O cell/O volume/O dynamics/O in/O intact/O rat/O hearts/O ,/O during/O ischemia/O and/O after/O reperfusion/O ./O
In/O contrast/O ,/O COUP/I -/I TF/I alone/O had/O no/O effect/O on/O repCRS2/O -/O dependent/O reporter/O gene/O activity/O ./O
DNA/O sequencing/O and/O Southern/O blot/O analyses/O established/O that/O the/O cDNA/O clones/O are/O derived/O from/O two/O different/O genes/O ./O
Muscle/I GSH/I -/I Px/I activity/O after/O prolonged/O exercise/O ,/O training/O ,/O and/O selenium/O supplementation/O ./O
Mutation/O of/O the/O Sp1/I element/I ,/O which/O abolishes/O Sp1/I binding/O ,/O results/O in/O a/O 6/O -/O 10/O -/O fold/O reduction/O in/O reporter/O activity/O ./O
The/O c/I -/I myc/I gene/I is/O overexpressed/O in/O a/O variety/O of/O tumor/O types/O and/O appears/O to/O play/O an/O important/O role/O in/O the/O abnormal/O growth/O of/O a/O number/O of/O cell/O types/O ./O
We/O found/O that/O PML/I was/O expressed/O at/O a/O lower/O level/O in/O S/O ,/O G2/O ,/O and/O M/O phases/O and/O at/O a/O significantly/O higher/O level/O in/O G1/O phase/O ./O
Schooling/O is/O found/O to/O be/O related/O to/O good/O health/O even/O after/O controlling/O for/O differences/O in/O observable/O health/O inputs/O ./O
With/O this/O bisected/O diastolic/O driving/O ,/O the/O abnormal/O echo/O disappeared/O completely/O ./O
It/O acts/O on/O Cdks/I in/O the/O G1/O and/O S/O phases/O of/O the/O cell/O cycle/O ,/O and/O also/O binds/O to/O proliferating/I cell/I nuclear/I antigen/I (/O PCNA/I ),/O blocking/O DNA/O replication/O in/O vitro/O ./O
Two/O major/O and/O one/O minor/O transcription/O initiation/O sites/O were/O assigned/O to/O positions/O +/O 1/O and/O +/O 24/O and/O position/O +/O 14/O ,/O respectively/O ,/O by/O a/O combination/O of/O ribonuclease/O protection/O ,/O primer/O extension/O ,/O and/O 5/O '/O RACE/O analyses/O ./O
The/O roxithromycin/O doses/O that/O were/O chosen/O for/O these/O studies/O were/O less/O than/O achievable/O blood/O levels/O ./O
We/O demonstrate/O here/O that/O the/O -/O DEDDDL/O sequence/O stabilizes/O GDP/O binding/O to/O Ran/I ,/O and/O that/O the/O domain/O is/O required/O for/O high/O affinity/O interaction/O with/O a/O Ran/I -/I binding/I protein/I ,/O HTF9A/I //O RanBP1/I ./O
Further/O ,/O the/O ORFs/O of/O components/O 3/O and/O 5/O potentially/O encoded/O proteins/O of/O about/O 20/O kDa/O ,/O the/O size/O of/O the/O BBTV/I coat/I protein/I ./O
Serial/O followup/O strength/O data/O for/O 2/O patients/O were/O compared/O to/O change/O in/O creatinine/I kinase/I (/O CK/I )/O levels/O ./O
CodY/I does/O not/O have/O any/O homologues/O in/O the/O data/O -/O bases/O ./O
OBJECTIVE/O :/O To/O investigate/O the/O incidence/O and/O presentation/O of/O acute/O pernicious/O or/O fulminating/O beriberi/O in/O a/O general/O district/O hospital/O ./O
Unlike/O most/O other/O small/I G/I proteins/I which/O are/O expressed/O ubiquitously/O ,/O TTF/I was/O transcribed/O only/O in/O hemopoietic/O cells/O as/O a/O 2/O ./O 2/O kb/O transcript/O ./O
An/O explanation/O explored/O for/O this/O lack/O of/O gene/O expression/O was/O that/O increased/O levels/O of/O RAR/I alpha/I or/O PML/I might/O suppress/O APL/O cell/O growth/O ./O
Transfection/O of/O non/O -/O deleted/O expression/O vector/O into/O NIH3T3/O cells/O results/O in/O acquisition/O of/O focus/O -/O forming/O activity/O while/O a/O deleted/O form/O of/O expression/O vector/O fails/O to/O show/O this/O activity/O even/O in/O the/O presence/O of/O basic/I FGF/I ./O
Cytosolic/O extracts/O from/O a/O variety/O of/O mammalian/O cell/O lines/O (/O monkey/O Cos7/O ,/O several/O mouse/O fibrosarcomas/O and/O human/O HeLa/O S3/O )/O demonstrated/O similar/O TGF/I -/I beta/I 1/I dependent/O RNA/O -/O protein/O band/O shifts/O as/O cell/O extract/O from/O BALB/O //O c/O 3T3/O mouse/O fibroblasts/O ./O
All/O ribosomal/I protein/I (/O rp/I )/O gene/O promoters/O from/O Saccharomyces/O cerevisiae/O studied/O so/O far/O contain/O either/O (/O usually/O two/O )/O binding/O sites/O for/O the/O global/O gene/O regulator/O Rap1p/I or/O one/O binding/O site/O for/O another/O global/O factor/O ,/O Abf1p/I ./O
The/O provisional/O reports/O are/O based/O mainly/O upon/O macroscopic/O findings/O ,/O whereas/O the/O final/O reports/O include/O the/O information/O provided/O by/O supplementary/O investigations/O such/O as/O microscopy/O ,/O histochemistry/O ,/O more/O rarely/O electron/O microscopy/O ,/O immunohistochemistry/O and/O //O or/O microbiology/O ./O
Circulating/O thrombomodulin/I :/O current/O knowledge/O and/O future/O prospects/O
CPT/O -/O 11/O was/O administered/O as/O a/O 30/O -/O minute/O i/O ./O v/O ./O infusion/O at/O a/O dose/O of/O 350/O mg/O //O m2/O diluted/O in/O 250/O ml/O normal/O saline/O every/O 3/O weeks/O ./O
CONCLUSION/O :/O The/O MTD/O for/O CPT/O -/O 11/O administered/O in/O a/O 3/O consecutive/O -/O days/O -/O every/O -/O 3/O weeks/O schedule/O in/O this/O patient/O population/O is/O 115/O mg/O //O m2/O //O day/O ./O
A/O 73/O bp/O fragment/O (/O X1/O region/O )/O of/O the/O PRB/I -/I 1b/I promoter/I ,/O located/O between/O positions/O -/O 213/O and/O -/O 141/O ,/O was/O sufficient/O to/O confer/O ethylene/O responsiveness/O to/O the/O reporter/O gene/O ./O
To/O assess/O the/O function/O (/O s/O )/O of/O E74/I during/O metamorphosis/O ,/O we/O have/O isolated/O and/O characterized/O recessive/O loss/O -/O of/O -/O function/O mutations/O specific/O to/O each/O transcription/O unit/O ./O
Although/O the/O extracellular/O domain/O of/O the/O TSH/I -/I R/I is/O sufficient/O for/O high/O affinity/O binding/O of/O TSH/I ,/O we/O conclude/O that/O the/O hyt/O mutation/O in/O the/O fourth/O transmembrane/O domain/O eliminates/O TSH/I binding/O ./O
Lipiodol/O was/O covalently/O conjugated/O with/O EDTB/O ./O
Moreover/O ,/O Western/O blots/O demonstrated/O at/O least/O six/O types/O of/O Ypt/I in/O both/O Cr/O and/O Vc/O ,/O suggesting/O that/O these/O Ypt/I are/O used/O for/O household/O functions/O responsible/O for/O vesicle/O transport/O rather/O than/O for/O cellular/O differentiation/O ./O
The/O absence/O of/O other/O regions/O of/O hybridization/O suggests/O that/O there/O are/O no/O closely/O related/O sequences/O (/O e/O ./O g/O .,/O reverse/O transcribed/O pseudogenes/O )/O scattered/O throughout/O the/O genome/O and/O that/O if/O there/O are/O closely/O related/O genes/O ,/O they/O must/O be/O clustered/O near/O GSTT2/I ./O
However/O ,/O the/O lens/O dose/O (/O 3/O ./O 6/O Gy/O //O 25/O fractions/O )/O was/O higher/O compared/O to/O the/O other/O techniques/O ./O
Antibodies/O to/O the/O human/I PTS1R/I recognize/O this/O protein/O in/O human/O ,/O monkey/O ,/O rat/O ,/O and/O hamster/O cells/O ./O
There/O is/O a/O national/O effort/O to/O begin/O to/O ask/O all/O female/O patients/O about/O family/O violence/O ./O
GnRH/I treatment/O was/O found/O to/O increase/O the/O phosphorylation/O of/O tyrosine/O residues/O of/O MAPK/I and/O to/O increase/O MAPK/I activity/O ,/O as/O determined/O by/O an/O immune/O complex/O kinase/O assay/O ./O
Molecular/O cloning/O of/O an/O amphibian/I insulin/I receptor/I substrate/I 1/I -/I like/I cDNA/I and/O involvement/O of/O phosphatidylinositol/I 3/I -/I kinase/I in/O insulin/I -/O induced/O Xenopus/O oocyte/O maturation/O ./O
We/O report/O here/O that/O in/O cultured/O Jurkat/O T/O cells/O ,/O Cbl/I is/O coprecipitated/O with/O antibody/O against/O the/O adapter/I protein/I Grb2/I ./O
The/O effect/O of/O these/O cell/O cycle/O regulators/O is/O not/O specific/O to/O the/O rap1s/I or/O hmr/I delta/I A/I mutation/I ,/O since/O swi6/I ,/O swi4/I ,/O and/O clb5/I mutations/I also/O suppress/O mutations/O in/O SIR1/I ,/O another/O gene/O implicated/O in/O the/O establishment/O of/O silencing/O ./O
ICP4/I has/O been/O shown/O to/O form/O tripartite/O complexes/O cooperatively/O with/O the/O TATA/I box/I -/I binding/I protein/I and/O TFIIB/I on/O DNA/O containing/O an/O ICP4/I binding/I site/I and/O a/O TATA/O box/O (/O C/O ./O
Otte/O ,/O Mol/O ./O
Characterization/O of/O fus1/I of/O Schizosaccharomyces/O pombe/O :/O a/O developmentally/O controlled/O function/O needed/O for/O conjugation/O ./O
SRY/I -/I related/I cDNA/I encoding/O a/O protein/O with/O a/O high/I -/I mobility/I -/I group/I (/O HMG/I )/O box/O and/O a/O leucine/O zipper/O motif/O ,/O which/O was/O designated/O SOX/I -/I LZ/I ,/O was/O isolated/O from/O a/O rainbow/O trout/O testis/O cDNA/O library/O ./O
Scalp/O flaps/O can/O be/O expanded/O just/O to/O the/O point/O of/O becoming/O noticeable/O over/O 4/O to/O 6/O weeks/O followed/O by/O scalp/O flap/O transposition/O and/O easy/O closure/O of/O the/O donor/O site/O ./O
In/O the/O Center/O for/O Human/O Genetics/O in/O Leuven/O ,/O predictive/O DNA/O -/O testing/O for/O Huntington/O '/O s/O disease/O is/O available/O as/O a/O clinical/O service/O since/O November/O 1987/O ,/O initially/O by/O DNA/O -/O linkage/O and/O since/O mid/O 1993/O by/O direct/O mutation/O analysis/O ./O
Risks/O of/O chronicity/O following/O acute/O hepatitis/O B/O virus/O infection/O :/O a/O review/O ./O
Examination/O of/O neurohumoral/O factors/O revealed/O a/O hyperactive/O sympathetic/O nervous/O system/O and/O an/O increase/O in/O plasma/O renin/I activity/O ./O
We/O compared/O the/O inhibitory/O effect/O of/O naturally/O occurring/O mutant/I hTR/I beta/I 1/I ,/O artificially/O created/O hTR/I alpha/I 1/I mutants/I ,/O c/I -/I erbA/I alpha/I 2/I and/O the/O human/I peroxisome/I proliferator/I -/I activated/I receptor/I (/O hPPAR/I )/O on/O three/O prototypic/O T3/O -/O response/O elements/O (/O TREs/O ),/O TRE/O -/O PAL/O ,/O DR/O +/O 4/O and/O TRE/O -/O LAP/O ./O
The/O amino/O -/O terminal/O DNA/O -/O binding/O domain/O of/O Pip/I exhibits/O a/O high/O degree/O of/O homology/O to/O the/O DNA/O -/O binding/O domains/O of/O members/O of/O the/O interferon/I regulatory/I factor/I (/O IRF/I )/O family/O ,/O which/O includes/O IRF/I -/I 1/I ,/O IRF/I -/I 2/I ,/O ICSBP/I ,/O and/O ISGF3/I gamma/I ./O
An/O outbreak/O of/O hepatitis/O A/O among/O homosexual/O men/O in/O Amsterdam/O ,/O 1991/O -/O 1993/O ./O
The/O RAP74/I subunit/I of/O TFIIF/I alone/O contained/O the/O stimulatory/O activity/O and/O the/O minimal/O region/O sufficient/O for/O stimulation/O corresponds/O to/O COOH/O -/O terminal/O residues/O 358/O -/O 517/O ./O
We/O have/O generated/O various/O base/O substitutions/O and/O internal/O deletions/O in/O and/O around/O DRE/O (/O nucleotide/O positions/O -/O 93/O to/O -/O 100/O with/O respect/O to/O the/O transcription/O initiation/O site/O )/O of/O the/O PCNA/I gene/I in/O vitro/O and/O subsequently/O examined/O their/O effects/O on/O the/O binding/O to/O DREF/I (/O DRE/I -/I binding/I factor/I )/O and/O PCNA/I gene/I promote/O activity/O in/O cultured/O Drosophila/O Kc/O cells/O as/O well/O as/O in/O living/O flies/O ./O
The/O hsp70/I gene/I family/I of/O Neurospora/O crassa/O :/O cloning/O ,/O sequence/O analysis/O ,/O expression/O ,/O and/O genetic/O mapping/O of/O the/O major/O stress/O -/O inducible/O member/O ./O
The/O deduced/O amino/O acid/O sequences/O of/O each/O of/O the/O W3A1/I ETF/I subunits/I exhibit/O only/O approximately/O 30/O %/O identity/O with/O the/O corresponding/O subunits/O of/O the/O ETF/I from/O human/O ,/O rat/O ,/O and/O Paracoccus/O denitrificans/O ,/O which/O as/O a/O group/O are/O greater/O than/O 50/O %/O identical/O ./O
A/O secondary/O phosphorylation/O of/O CREB341/I at/O Ser129/O is/O required/O for/O the/O cAMP/O -/O mediated/O control/O of/O gene/O expression/O ./O
A/O role/O for/O glycogen/I synthase/I kinase/I -/I 3/I in/O the/O control/O of/O gene/O expression/O ./O
This/O last/O region/O contains/O two/O sites/O that/O bind/O Ets/I -/I related/I proteins/I present/O in/O liver/O nuclear/O extracts/O as/O well/O as/O recombinant/I purified/I Ets/I -/I 1/I protein/I ./O
Other/O assays/O also/O distinguished/O the/O processive/O replication/O of/O pNeo/O ./O Myc/O -/O 2/O ./O 4/O from/O the/O dispersive/O labeling/O of/O control/O plasmids/O ./O
Reconstitution/O of/O complexes/O containing/O p62/I and/O the/O src/I family/I kinase/I p59fyn/I in/O HeLa/O cells/O demonstrated/O that/O complex/O formation/O resulted/O in/O tyrosine/O phosphorylation/O of/O p62/I and/O was/O mediated/O by/O both/O the/O SH3/I and/O SH2/I domains/I of/O p59fyn/I ./O
Therefore/O ,/O it/O is/O hoped/O that/O by/O defining/O the/O transcriptional/O control/O of/O the/O L7/I gene/I insights/O into/O the/O mechanisms/O that/O control/O functional/O fate/O and/O organization/O in/O the/O nervous/O system/O can/O be/O gained/O ./O
In/O contrast/O ,/O a/O Maf/I -/I related/I protein/I ,/O Nrl/I ,/O completely/O mimicked/O c/I -/I Maf/I actions/O ./O
The/O 27/O -/O base/O element/O interacts/O with/O a/O PDGF/I -/O activated/O serine/O //O threonine/O phosphoprotein/O that/O is/O detected/O only/O within/O the/O nucleus/O of/O PDGF/O -/O treated/O 3T3/O cells/O ./O
By/O contrast/O ,/O deletion/O of/O this/O Ras/I -/I binding/I site/I did/O not/O diminish/O activation/O of/O Raf/I -/I 1/I kinase/I by/O Src/I ,/O implying/O that/O Src/I and/O Ras/I can/O activate/O Raf/I -/I 1/I through/O independent/O mechanisms/O ./O
In/O studies/O of/O many/O different/O phenotypically/O distinct/O cells/O ,/O the/O CRE/O of/O the/O somatostatin/I gene/I promoter/I is/O a/O prototype/O of/O a/O highly/O cAMP/O -/O responsive/O element/O regulated/O by/O CREB/I ./O
The/O first/O gene/O ,/O NSR1/I ,/O a/O previously/O identified/O gene/O ,/O encodes/O a/O protein/O involved/O in/O ribosomal/O RNA/O maturation/O and/O possibly/O in/O transport/O of/O proteins/O into/O the/O nucleus/O ./O
Characterization/O of/O the/O promoter/O for/O the/O human/I 85/I kDa/I cytosolic/I phospholipase/I A2/I gene/I ./O
This/O paper/O describes/O the/O advantages/O and/O limitations/O of/O the/O main/O study/O approaches/O used/O ./O
Comparative/O study/O of/O the/O differential/O white/O blood/O cell/O count/O using/O three/O automated/O analyzers/O :/O Coulter/O STKS/O ,/O Sysmex/O NE/O 8000/O and/O Technicon/O H/O -/O 1/O ./O
Characterization/O of/O FIII/I //O YY1/I ,/O a/O Xenopus/I laevis/I conserved/I zinc/I -/I finger/I protein/I binding/O to/O the/O first/O exon/O of/O L1/I and/O L14/I ribosomal/I protein/I genes/I ./O
Further/O studies/O established/O that/O the/O Ep/I -/O induced/O increase/O in/O beta/I -/I globin/I mRNA/I could/O be/O inhibited/O by/O the/O tyrosine/I kinase/I inhibitor/O genistein/O and/O the/O protein/I kinase/I C/I inhibitor/O Compound/O 3/O .(/O ABSTRACT/O TRUNCATED/O AT/O 250/O WORDS/O )/O
This/O structure/O of/O cucumisin/I suggests/O that/O it/O is/O probably/O synthesized/O as/O an/O inactive/O precursor/O ./O
Molecular/O dissection/O of/O the/O multimeric/O CD3/I -/O TCR/I complex/O revealed/O that/O at/O least/O two/O associated/O polypeptides/O ,/O CD3/I zeta/I and/O CD3/I epsilon/I ,/O autonomously/O couple/O antigenic/O recognition/O event/O to/O early/O and/O late/O events/O of/O the/O intracytoplasmic/O activation/O cascade/O ./O
Protein/I cHMGI/I binds/O preferentially/O to/O AT/O -/O rich/O DNA/O with/O a/O half/O -/O saturation/O value/O of/O 1/O ./O 1/O nM/O ./O
This/O study/O investigated/O the/O degree/O to/O which/O racial/O identity/O influences/O Mexican/O -/O Americans/O '/O performance/O on/O the/O L/O ,/O K/O ,/O and/O MF/O scales/O of/O the/O MMPI/O -/O 2/O ./O
Both/O can/O be/O elevated/O on/O a/O single/O vascular/O pedicle/O based/O on/O the/O superficial/O temporal/O artery/O ,/O the/O double/O -/O layered/O temporal/O fascia/O flap/O ./O
To/O do/O this/O ,/O segments/O of/O DNA/O from/O the/O 5/O '/O flank/O of/O the/O initiation/O sites/O for/O germline/O epsilon/O RNA/O were/O ligated/O to/O a/O luciferase/I reporter/I gene/I and/O transfected/O into/O two/O mouse/O B/O cell/O lines/O ,/O one/O of/O which/O can/O be/O induced/O to/O switch/O to/O IgE/I ./O
The/O negative/O predictive/O value/O is/O 92/O %,/O vs/O 80/O %/O for/O the/O NCEP/O I/O ./O
Oncogenic/O capacity/O of/O the/O E2F1/I gene/I ./O
In/O some/O of/O the/O cases/O of/O solitary/O lesion/O ,/O serum/I TSH/I levels/O ,/O serum/I thyroglobulin/I values/O ,/O and/O 131I/O protein/O bounded/O iodine/O (/O 131I/O -/O PBI/O )/O were/O measured/O ,/O but/O there/O were/O no/O significant/O differences/O between/O successful/O and/O unsuccessful/O therapy/O ./O
Endo16/I transcripts/I are/O confined/O to/O the/O definitive/O vegetal/O plate/O in/O blastula/O stage/O embryos/O ;/O at/O gastrula/O stage/O this/O gene/O is/O expressed/O throughout/O the/O archenteron/O ,/O but/O later/O only/O in/O the/O midgut/O ./O
A/O unique/O leucine/O -/O proline/O repeat/O element/O found/O N/O -/O terminal/O to/O the/O DNA/O -/O binding/O domain/O of/O EmBP/I -/I 1/I does/O not/O appear/O to/O play/O a/O role/O in/O DNA/O -/O binding/O or/O dimerization/O ./O
Another/O full/O ORF/O was/O found/O on/O the/O opposite/O strand/O downstream/O from/O the/O nspC/I gene/I ./O
The/O U14/I genes/I of/O mouse/O as/O well/O as/O rat/O ,/O hamster/O ,/O human/O ,/O Xenopus/O and/O trout/O are/O encoded/O within/O introns/O of/O the/O constitutively/O expressed/O 70/I -/I kDa/I -/I cognate/I -/I heat/I -/I shock/I protein/I gene/I (/O hsc70/I )./O
Two/O related/O cDNAs/O were/O isolated/O that/O encode/O proteins/O that/O recognize/O the/O XMyoDa/I TATA/I motif/I ./O
Deletion/O of/O both/O prfA/I and/O ponA/I resulted/O in/O extremely/O slow/O growth/O and/O a/O reduction/O in/O sporulation/O efficiency/O ./O
Inclusion/O in/O this/O family/O of/O proteins/O suggests/O that/O FliQ/I and/O FliR/I may/O participate/O in/O an/O export/O pathway/O required/O for/O flagellum/O assembly/O ./O
In/O broken/O L/O -/O cell/O membranes/O expressing/O wild/O type/O or/O mutant/I M6P/I //I IGF/I II/I receptors/I ,/O 30/O nM/O IGF/I II/I also/O failed/O to/O affect/O the/O pertussis/I toxin/I substrate/O activity/O ./O
Chem/O ./O
For/O the/O first/O time/O we/O describe/O deletion/O and/O point/O mutations/O within/O the/O plasma/I membrane/I family/I of/I guanylyl/I cyclase/I receptors/I that/O result/O in/O the/O formation/O of/O effective/O dominant/O negative/O proteins/O ./O
Increase/O in/O blood/O NEFA/O was/O further/O augmented/O by/O fat/O plus/O AA/O supplementation/O ,/O but/O no/O changes/O in/O concentrations/O of/O Lys/O or/O Met/O in/O blood/O were/O found/O ./O
Virol/O ./O
Coronary/O vasoconstriction/O caused/O by/O endothelin/I -/I 1/I is/O enhanced/O by/O ischemia/O -/O reperfusion/O and/O by/O norepinephrine/O present/O in/O concentrations/O typically/O observed/O after/O neonatal/O cardiopulmonary/O bypass/O ./O
Comparison/O of/O the/O deduced/O amino/I acid/I sequence/I of/I gamma/I -/I kafirin/I with/O the/O published/O sequences/I of/I gamma/I -/I prolamins/I of/I maize/I ,/I and/I Coix/I revealed/O highly/O conserved/O domains/O ./O
Atcys1/I ,/O Athyp1/I ,/O AKin10/I and/O the/O ORF/O are/O very/O close/O to/O each/O other/O and/O organized/O in/O the/O same/O polarity/O ;/O hence/O ,/O the/O intergenic/O regions/O probably/O contain/O ,/O within/O less/O than/O 0/O ./O 5/O kb/O ,/O all/O the/O regulatory/O elements/O necessary/O to/O govern/O initiation/O and/O termination/O of/O transcription/O ./O
Southern/O blot/O hybridization/O experiments/O suggest/O the/O presence/O of/O one/O copy/O of/O Atcys1/I ,/O Athyp1/I and/O AKin10/I per/O haploid/O genome/O ,/O and/O Northern/O blot/O analysis/O demonstrates/O that/O the/O three/O genes/O are/O differentially/O expressed/O in/O roots/O ,/O shoots/O and/O leaves/O ./O
These/O results/O suggest/O that/O HAC1/I may/O also/O be/O one/O of/O the/O meiotic/O genes/O ./O
We/O characterized/O three/O Arabidopsis/O thaliana/O cDNA/O clones/O that/O could/O rescue/O the/O sterile/O phenotype/O of/O the/O Schizosaccharomyces/I pombe/I pde1/I mutant/I ,/O which/O is/O defective/O in/O cAMP/I phosphodiesterase/I ./O
Furthermore/O ,/O the/O identification/O of/O a/O Dr1/I -/I like/I protein/I in/O A/O ./O thaliana/O strongly/O argues/O for/O the/O ubiquity/O of/O this/O protein/O among/O eukaryotic/O genera/O and/O for/O a/O conserved/O mechanism/O to/O regulate/O transcription/O initiation/O that/O involves/O Dr1/I ./O
Similarly/O approximately/O 300/O bp/O of/O sequence/O downstream/O of/O the/O translation/O terminator/O TGA/O of/O the/O beta/I -/I tubulin/I 2/I (/O BTU2/I )/O gene/O could/O substitute/O for/O the/O 3/O '/O region/O of/O the/O H4/I -/I I/I gene/I ./O
These/O data/O demonstrate/O that/O the/O STR/I family/I of/O genes/O is/O represented/O in/O a/O nematode/O whose/O ancestor/O appeared/O well/O before/O the/O branching/O that/O gave/O rise/O to/O the/O Arthropoda/O and/O Chordata/O ./O
The/O pre/O -/O and/O postoperative/O haemoglobin/I concentrations/O in/O the/O autologous/O group/O were/O lower/O by/O 15/O and/O 10/O g/O //O L/O ,/O respectively/O ,/O after/O primary/O THR/O and/O by/O 10/O g/O //O L/O in/O both/O instances/O after/O revision/O THR/O ./O
The/O introduction/O of/O an/O acidic/O residue/O at/O the/O second/O site/O was/O essential/O for/O suppression/O of/O the/O Asn/O -/O 285/O mutation/O because/O Lys/O -/O 220/O and/O Gln/O -/O 220/O second/O -/O site/O mutants/O of/O the/O Asn/O -/O 285/O mutant/O showed/O very/O low/O tetracycline/O resistance/O .(/O ABSTRACT/O TRUNCATED/O AT/O 250/O WORDS/O )/O
Tumor/I necrosis/I factor/I alpha/I ,/O the/O cytokine/O that/O participates/O in/O the/O autocrine/O growth/O control/O of/O hairy/O cell/O leukemia/O has/O strong/O bone/O resorptive/O properties/O ./O
(/O iv/O )/O Although/O UCRBP/I has/O been/O previously/O shown/O to/O act/O as/O a/O transcriptional/O repressor/O ,/O we/O show/O here/O that/O UCRBP/I can/O also/O act/O as/O a/O positive/O transactivator/O of/O a/O reporter/O driven/O by/O UCR/O elements/O when/O used/O in/O co/O -/O transfection/O assays/O ./O
The/O sequence/O of/O monkey/I opsin/I closely/O resembles/O the/O human/O sequence/O at/O the/O nucleotide/O and/O the/O amino/O acid/O levels/O ,/O with/O the/O latter/O having/O only/O 7/O differences/O out/O of/O 348/O residues/O ./O
One/O complex/O appears/O to/O be/O ubiquitous/O but/O enriched/O in/O lymphoid/O cells/O and/O represents/O the/O binding/O of/O a/O potentially/O novel/O factor/O with/O an/O apparent/O molecular/O mass/O of/O approximately/O 50/O kDa/O ./O
Chem/O ./O
Conversely/O ,/O activation/O of/O Oct/I -/I 3/I //I 4/I promoter/I by/O RAR/I :/O RXR/I heterodimers/I was/O completely/O abolished/O by/O EAR/I -/I 3/I //O COUP/I -/I TFI/I and/O by/O ARP/I -/I 1/I //O COUP/I -/I TFII/I ./O
These/O results/O demonstrate/O that/O EKLF/I provides/O a/O crucial/O transactivation/O function/O for/O globin/I expression/O and/O further/O reinforce/O the/O idea/O that/O EKLF/I is/O an/O important/O regulator/O of/O CACCC/O element/O -/O directed/O transcription/O in/O erythroid/O cells/O ./O
Using/O a/O battery/O of/O I/I kappa/I B/I alpha/I mutants/I ,/O we/O show/O that/O (/O i/O )/O a/O dimer/O binds/O a/O single/O I/I kappa/I B/I alpha/I molecule/I ,/O (/O ii/O )/O the/O acidic/O C/O -/O terminal/O region/O of/O I/I kappa/I B/I alpha/I is/O not/O required/O for/O protein/O -/O protein/O binding/O and/O does/O not/O mask/O the/O nuclear/O localization/O signal/O of/O the/O dimer/O ,/O (/O iii/O )/O the/O same/O C/O -/O terminal/O region/O is/O required/O for/O inhibition/O of/O DNA/O binding/O ,/O and/O (/O iv/O )/O this/O inhibition/O may/O be/O accomplished/O by/O direct/O interaction/O between/O the/O PEST/O -/O like/O region/O and/O the/O DNA/O -/O binding/O region/O of/O one/O of/O the/O subunits/O of/O the/O dimer/O ./O
The/O negative/O regulatory/O activity/O of/O the/O N/O -/O terminal/O domain/O was/O antagonized/O by/O a/O C/O -/O terminal/O segment/O of/O Pho81p/I supplied/O in/O trans/O ./O
At/O different/O times/O of/O the/O surgical/O procedures/O (/O thorax/O opening/O and/O closure/O ,/O period/O of/O cardiopulmonary/O bypass/O )/O 67/O to/O 100/O %/O of/O the/O patients/O in/O group/O 1/O had/O vancomycin/O concentrations/O in/O the/O studied/O tissues/O above/O the/O MIC/O 90/O for/O Staphylococcus/O aureus/O (/O 1/O microgram/O //O g/O )/O and/O Staphylococcus/O epidermidis/O (/O 2/O micrograms/O //O g/O )./O
On/O -/O line/O angioscopic/O images/O of/O tissue/O flaps/O floating/O in/O the/O lumen/O ,/O recent/O or/O structured/O thrombi/O ,/O artery/O wall/O dissections/O ,/O plaque/O ruptures/O ,/O deep/O fissurations/O and/O sub/O -/O intimal/O haemorrhages/O demonstrate/O ,/O in/O live/O colour/O ,/O the/O pathophysiological/O mechanisms/O of/O coronary/O artery/O stenosis/O ./O
The/O enhanced/O cysteine/O formation/O in/O a/O pCSK4F/O plant/O responding/O to/O sulfite/O was/O also/O observed/O in/O leaf/O discs/O ./O
Each/O type/O was/O divided/O into/O two/O subgroups/O on/O the/O basis/O of/O whether/O the/O body/O and/O tail/O of/O the/O pancreas/O showed/O intense/O fatty/O replacement/O (/O type/O a/O =/O negative/O for/O intense/O fatty/O replacement/O ,/O type/O b/O =/O positive/O for/O intense/O fatty/O replacement/O )./O
Between/O the/O subgroups/O of/O dementia/O disorders/O there/O were/O no/O significant/O differences/O in/O basal/O cortisol/O levels/O ./O
A/O new/O hypothesis/O on/O mechanisms/O for/O inhibiting/O catalytic/O subunits/O by/O gamma/O -/O subunits/O and/O activation/O of/O a/O holoenzyme/O by/O transducin/I
Basal/O components/O of/O the/O transcription/O apparatus/O (/O RNA/I polymerase/I II/I ,/O TATA/I -/I binding/I protein/I )/O contain/O activation/O domains/O :/O is/O the/O repetitive/O C/O -/O terminal/O domain/O (/O CTD/O )/O of/O RNA/I polymerase/I II/I a/O "/O portable/O enhancer/O domain/O "?/O Regions/O rich/O in/O serine/O ,/O threonine/O ,/O and/O proline/O residues/O can/O be/O found/O in/O transcriptional/O activation/O domains/O ,/O as/O well/O as/O in/O the/O N/O -/O terminal/O parts/O of/O mammalian/I TATA/I -/I binding/I proteins/I ,/O where/O they/O are/O interrupted/O by/O polyglutamine/O stretches/O ./O
Mutagenesis/O of/O IM1/I enhances/O the/O ability/O of/O c/I -/I Fos/I to/O activate/O an/O AP1/I bearing/I promoter/I ./O
Binding/O of/O SSP/I to/O the/O stage/I selector/I element/I (/O SSE/I )/O in/O the/O proximal/O gamma/I -/I globin/I promoter/I is/O integral/O to/O the/O competitive/O silencing/O of/O a/O linked/O beta/I -/I promoter/I in/O embryonic/O //O fetal/O stage/O erythroleukemia/O (/O K562/O )/O cells/O ./O
This/O failure/O to/O execute/O regulated/O G1/O //O S/O arrest/O is/O correlated/O with/O enhanced/O thermosensitivity/O of/O colony/O -/O forming/O ability/O ./O
Mutations/O that/O alter/O photoreceptor/O cell/O structure/O and/O development/O were/O isolated/O that/O fail/O to/O complement/O these/O deletions/O ./O
It/O is/O possible/O that/O the/O telomeres/O of/O the/O two/O nuclei/O have/O different/O functions/O ./O
The/O marker/O orders/O from/O the/O genetic/O and/O RH/O maps/O were/O consistent/O ./O
Integrated/O mapping/O analysis/O of/O the/O Werner/O syndrome/O region/O of/O chromosome/O 8/O ./O
The/O region/O between/O DXS52/I and/O Factor/I VIII/I gene/I in/O the/O human/O Xq28/O chromosomal/O band/O contains/O a/O G/O +/O C/O -/O rich/O isochore/O to/O which/O many/O genes/O have/O been/O mapped/O ./O
Haplotype/O mapping/O and/O sequence/O analysis/O of/O the/O mouse/O Nramp/I gene/I predict/O susceptibility/O to/O infection/O with/O intracellular/O parasites/O ./O
This/O utilization/O of/O an/O intronic/O polyadenylation/O site/O without/O alternative/O exon/O usage/O is/O comparable/O to/O the/O mechanism/O whereby/O both/O secreted/O and/O membrane/O -/O bound/O forms/O of/O the/O immunoglobulin/I mu/I heavy/I chain/I are/O made/O from/O a/O single/O genetic/O locus/O ./O
To/O further/O our/O knowledge/O about/O the/O systemic/O humoral/O immune/O system/O response/O to/O weak/O hapten/O -/O syngeneic/O or/O allogeneic/O protein/O conjugates/O (/O corrosion/O and/O wear/O products/O of/O metallic/O orthopedic/O devices/O ),/O a/O sensitive/O enzyme/O -/O linked/O immunosorbent/O assay/O (/O ELISA/O )/O method/O for/O testing/O for/O antibody/O (/O humoral/O immunity/O )/O to/O metals/O was/O developed/O ./O
In/O contrast/O ,/O peak/O filling/O rate/O (/O PFR/O ),/O normalized/O to/O end/O diastolic/O volume/O (/O EDV/O ),/O or/O stroke/O volume/O (/O SV/O ),/O or/O expressed/O as/O the/O ratio/O of/O PFR/O -/O to/O -/O PER/O was/O reduced/O (/O p/O /O or/O =/O 1/O )/O was/O low/O in/O the/O Jewish/O Israeli/O population/O ,/O compared/O to/O other/O demographic/O areas/O ./O
The/O mechanism/O whereby/O zeta/I PKC/I regulates/O NF/I -/I kappa/I B/I most/O probably/O involves/O the/O activation/O of/O a/O putative/O I/I kappa/I B/I kinase/I of/O molecular/O mass/O approximately/O 50/O kDa/O ,/O which/O phosphorylates/O and/O inactivates/O I/I kappa/I B/I ./O
Stable/O expression/O of/O truncated/I inositol/I 1/I ,/I 4/I ,/I 5/I -/I trisphosphate/I receptor/I subunits/I in/O 3T3/O fibroblasts/O ./O
The/O molecular/O basis/O for/O commitment/O of/O progenitors/O to/O the/O eosinophil/O lineage/O and/O mechanisms/O by/O which/O eosinophil/O -/O specific/O genes/O are/O expressed/O and/O regulated/O during/O differentiation/O is/O unknown/O ./O
We/O report/O the/O identification/O and/O characterization/O of/O myr/I 4/I (/O myosin/I from/I rat/I ),/O the/O first/O mammalian/I myosin/I I/I that/O is/O not/O closely/O related/O to/O brush/O border/O myosin/I I/I ./O
M/O .,/O and/O D/O ./O
In/O addition/O ,/O computer/O analysis/O suggests/O that/O sequences/O similar/O to/O the/O A/O stem/O element/O are/O present/O within/O the/O three/O AAV/I promoter/I regions/O ./O
At/O least/O some/O of/O the/O difference/O in/O stability/O of/O the/O two/O kinds/O of/O complexes/O was/O due/O to/O the/O fact/O that/O the/O dissociation/O rate/O of/O the/O A/O stem/O substrate/O from/O the/O protein/O -/O DNA/O complexes/O was/O approximately/O fourfold/O faster/O than/O that/O of/O the/O complete/O TR/I ./O
Processing/O of/O the/O NS3/O '-/O 5B/I polyprotein/O was/O complex/O and/O occurred/O rapidly/O ./O
However/O ,/O each/O promoter/O activated/O by/O IEP86/I was/O synergistically/O affected/O by/O the/O addition/O of/O IEP72/I ./O
32Pi/O labeling/O or/O isoelectric/O focusing/O analysis/O of/O eIF/I -/I 2/I alpha/I from/O conditional/O casein/I kinase/I II/I mutants/I indicated/O that/O phosphorylation/O of/O eIF/I -/I 2/I alpha/I is/O abolished/O or/O dephosphorylated/O forms/O of/O eIF/I -/I 2/I alpha/I are/O detected/O when/O these/O strains/O are/O grown/O at/O the/O restrictive/O growth/O conditions/O ./O
Thus/O ,/O YMIP/I is/O a/O functional/O homolog/O of/O RMIP/I and/O represents/O a/O new/O component/O of/O the/O yeast/O mitochondrial/O import/O machinery/O ./O
The/O R2/O region/O within/O the/O class/O I/O enhancer/O acts/O as/O a/O negative/O element/O in/O Ad12/O -/O transformed/O cells/O and/O exhibits/O a/O stronger/O binding/O activity/O than/O is/O observed/O in/O nontumorigenic/O Ad5/O -/O transformed/O cells/O ,/O which/O are/O not/O reduced/O in/O class/O I/O expression/O ./O
PURPOSE/O :/O To/O evaluate/O the/O kinetics/O of/O erythropoietin/I (/O EPO/I )/O production/O and/O address/O the/O pathogenesis/O of/O anemia/O of/O prematurity/O ,/O we/O measured/O EPO/I levels/O in/O infants/O during/O the/O first/O year/O of/O life/O ./O
The/O nerve/I growth/I factor/I beta/I gene/I (/O NGFB/I )/O belongs/O to/O a/O conserved/O syntenic/O group/O on/O human/O chromosome/O 1/O and/O mouse/O Chromosome/O 3/O ./O
Furthermore/O ,/O an/O upstream/O element/O ,/O collagen/O element/O I/O (-/O 370/O /-/O 344/O ),/O which/O shares/O homology/O with/O the/O LAP/I binding/O cis/O -/O element/O of/O the/O albumin/I promoter/I (/O 9/O of/O 13/O bp/O )/O is/O described/O ./O
Number/O and/O size/O of/O silver/O -/O stained/O nucleoli/O (/O Ag/O -/O NOR/O clusters/O )/O in/O canine/O seminomas/O :/O correlation/O with/O histological/O features/O and/O tumour/O behaviour/O ./O
We/O speculate/O that/O mast/O cell/O degranulation/O may/O be/O involved/O in/O the/O pathogenesis/O of/O necrobiosis/O by/O altering/O fibroblast/O enzyme/O activity/O and/O //O or/O producing/O prolonged/O inflammatory/O reactions/O ./O
Molecular/O cloning/O of/O a/O cysteine/I synthase/I cDNA/I from/O Citrullus/O vulgaris/O (/O watermelon/O )/O by/O genetic/O complementation/O in/O an/O Escherichia/O coli/O Cys/O -/O auxotroph/O ./O
In/O earlier/O studies/O we/O identified/O several/O regulatory/O elements/O that/O control/O transcriptional/O activation/O and/O aerobic/O repression/O of/O one/O of/O these/O genes/O ,/O COX5b/I ./O
Although/O elevated/O serum/O levels/O of/O antibodies/O to/O the/O nicotinic/I acetylcholine/I receptor/I (/O nAChR/I )/O have/O been/O reported/O in/O neuroleptic/O treated/O patients/O with/O tardive/O dyskinesia/O ,/O such/O antibodies/O have/O not/O been/O determined/O in/O comparable/O nondyskinetic/O patients/O ./O
The/O tumor/O suppressor/O and/O transcriptional/O factor/O p53/I is/O a/O phosphorylated/O protein/O ./O
This/O DNA/O containing/O promoter/O activity/O has/O been/O sequenced/O in/O its/O entirety/O and/O found/O to/O contain/O multiple/O putative/O regulatory/O sites/O ./O
However/O ,/O Southern/O blot/O and/O karyotype/O analyses/O did/O not/O reveal/O any/O significant/O changes/O in/O copy/O number/O or/O gross/O rearrangements/O of/O the/O p53/I gene/I in/O any/O of/O the/O p53/I -/I cell/O lines/O ./O
HupI/I showed/O strong/O identity/O to/O rubredoxin/I and/O rubredoxin/I -/I like/I proteins/I from/O many/O other/O bacteria/O ./O
The/O PCr/O resynthesis/O rate/O (/O P/O /O 30/O %/O of/O the/O informative/O cases/O was/O observed/O on/O chromosomes/O 3p/O (/O 41/O ./O 1/O %),/O 5q/O (/O 52/O ./O 6/O %),/O 6p/O (/O 30/O ./O 4/O %),/O 8p/O (/O 33/O ./O 3/O %),/O 9p/O (/O 35/O ./O 7/O %),/O 9q/O (/O 30/O ./O 8/O %),/O 11p/O (/O 32/O ./O 4/O %),/O 13q/O (/O 52/O ./O 7/O %),/O 17p/O (/O 55/O ./O 2/O %),/O 17q/O (/O 33/O ./O 3/O %),/O 18q/O (/O 45/O ./O 7/O %),/O and/O 19q/O (/O 30/O ./O 4/O %)./O
A/O single/O amino/O acid/O change/O in/O the/O CPY/I vacuolar/I sorting/I signal/I prevents/O this/O interaction/O ./O
Glutamyl/I -/I tRNA/I synthetase/I and/O prolyl/I -/I tRNA/I synthetase/I belong/O to/O different/O classes/O of/O aminoacyl/I -/I tRNA/I synthetases/I that/O are/O thought/O to/O have/O evolved/O along/O independent/O evolutionary/O pathways/O ./O
Using/O the/O sequence/O data/O obtained/O from/O the/O human/O TCRAC/I //O TCRDC/I region/O ,/O we/O have/O extended/O a/O polymerase/O chain/O reaction/O -/O based/O assay/O to/O test/O for/O the/O expression/O of/O the/O individual/O TCRAJ/I gene/I segments/I ./O
This/O analysis/O revealed/O an/O intact/O gene/O (/O arg4/I )/O showing/O a/O high/O degree/O of/O homology/O with/O the/O Saccharomyces/I cerevisiae/I CPA2/I gene/I encoding/O the/O large/O subunit/O of/O carbamoyl/I -/I phosphate/I synthetase/I (/O CPS/I -/I A/I )./O
Restriction/O analysis/O and/O Southern/O hybridization/O revealed/O the/O presence/O of/O Tn5422/I in/O all/O the/O plasmid/O -/O mediated/O cadmium/O -/O resistant/O L/O ./O monocytogenes/O strains/O tested/O but/O not/O in/O strains/O encoding/O cadmium/O resistance/O on/O the/O chromosome/O ./O
The/O baroreflex/O latency/O (/O from/O the/O ECG/O R/O -/O wave/O to/O the/O integrated/O MSNA/O burst/O peak/O )/O was/O constant/O at/O approximately/O 1/O ./O 20/O s/O during/O sleep/O ,/O suggesting/O that/O pulse/O -/O synchronicity/O was/O maintained/O ./O
DESIGN/O --/O A/O randomised/O study/O was/O conducted/O in/O all/O women/O aged/O 50/O -/O 70/O years/O who/O were/O eligible/O for/O breast/O cancer/O screening/O and/O living/O in/O the/O city/O of/O Utrecht/O ./O
Identification/O of/O an/O immediate/I -/I early/I gene/I in/O the/O Marek/O '/O s/O disease/O virus/O long/O internal/O repeat/O region/O which/O encodes/O a/O unique/O 14/O -/O kilodalton/O polypeptide/O ./O
We/O have/O used/O a/O full/O -/O length/O cDNA/O clone/O of/O a/O mouse/O hepatitis/O virus/O strain/O A59/O defective/O interfering/O (/O DI/O )/O RNA/O ,/O pMIDI/I -/I C/I ,/O and/O cassette/O mutagenesis/O to/O study/O the/O mechanism/O of/O coronavirus/O subgenomic/O mRNA/O synthesis/O ./O
To/O study/O the/O structure/O -/O function/O of/O the/O gene/I 5/I product/I ,/O wild/O -/O type/O and/O mutant/O forms/O of/O NS53/I were/O produced/O by/O using/O a/O recombinant/O baculovirus/O expression/O system/O and/O a/O recombinant/O vaccinia/O virus/O //O T7/O (/O vTF7/O -/O 3/O )/O expression/O system/O ./O
Gel/O electrophoresis/O and/O Western/O immunoblot/O analyses/O of/O intracellular/O fractions/O derived/O from/O infected/O cells/O revealed/O that/O large/O amounts/O of/O NS53/I were/O present/O in/O the/O cytosol/O and/O in/O association/O with/O the/O cytoskeletal/O matrix/O ./O
The/O transcription/I factor/I AP/I -/I 2/I is/O encoded/O by/O a/O gene/O located/O on/O chromosome/O 6/O near/O the/O HLA/I locus/I ./O
The/O mature/O AP/I -/I 2/I mRNA/I is/O spliced/O from/O 7/O exons/O distributed/O over/O a/O region/O of/O 18/O kb/O genomic/O DNA/O ./O
San/O Martin/O '/O s/O psychological/O traits/O coupled/O to/O his/O work/O with/O masonic/O lodges/O that/O allowed/O him/O to/O display/O his/O abilities/O as/O strategist/O and/O political/O ruler/O ./O
The/O participants/O were/O homosexual/O men/O in/O hepatitis/O B/O vaccine/O trials/O in/O Amsterdam/O (/O n/O =/O 74/O ),/O New/O York/O City/O (/O n/O =/O 120/O ),/O and/O San/O Francisco/O (/O n/O =/O 168/O )./O
The/O 7/O -/O day/O treatment/O resulted/O in/O a/O decrease/O in/O mitochondrial/O uptake/O of/O Rh123/O and/O an/O increase/O in/O NAO/O uptake/O ./O
Thrombotic/O thrombocytopenic/O purpura/O in/O systemic/O lupus/O erythematosus/O ./O
Comparison/O with/O the/O crystal/O structure/O of/O Desulfovibrio/O gigas/O ,/O Dg/O ,/O Fd/I (/O Kissinger/O et/O al/O .,/O 1991/O )/O reveals/O a/O very/O similar/O folding/O topology/O ,/O although/O several/O secondary/O structural/O elements/O are/O extended/O in/O Pf/O relative/O to/O Dg/O Fd/I ./O
CONCLUSIONS/O :/O Serum/I prolactin/I concentrations/O show/O age/O related/O variations/O in/O presumably/O fertile/O men/O ./O
Eight/O highly/O trained/O male/O kayakers/O were/O studied/O to/O determine/O the/O relationship/O between/O critical/O power/O (/O CP/O )/O and/O the/O onset/O of/O blood/O lactate/O accumulation/O (/O OBLA/O )./O
As/O in/O S/O ./O cerevisiae/O ,/O the/O sequence/O of/O rhp51/I +/I showed/O two/O MluI/I cell/I -/I cycle/I boxes/I and/O a/O putative/O DNA/O damage/O -/O responsive/O element/O in/O its/O upstream/O region/O ./O
Women/O '/O s/O opportunities/O for/O paid/O work/O outside/O the/O home/O are/O constrained/O by/O their/O role/O as/O primary/O carer/O within/O the/O family/O ,/O writes/O Trudy/O Wynne/O ./O
A/O partial/O cDNA/O sequence/O indicated/O that/O the/O T/I lymphocyte/I early/I -/I activation/I gene/I (/O Tea/I )/O encodes/O a/O protein/O related/O to/O the/O dual/O -/O function/O ecotropic/I retrovirus/I receptor/I //O cationic/I amino/I acid/I transporter/I (/O ecoR/I //O CAT1/I ),/O and/O RNA/O blots/O suggested/O highest/O Tea/I expression/O in/O T/O lymphocytes/O and/O liver/O (/O MacLeod/O ,/O C/O ./O L/O .,/O Finley/O ,/O K/O .,/O Kakuda/O ,/O D/O ./O
Furthermore/O ,/O unlike/O the/O case/O for/O HIS3/I where/O only/O a/O limited/O subset/O of/O TATA/O -/O like/O sequences/O can/O activate/O transcription/O in/O conjunction/O with/O GCN4p/I ,/O many/O divergent/O TATA/O -/O like/O sequences/O allowed/O GCN4p/I activation/O of/O TRP3/I ./O
Bacterially/O expressed/O protein/O ,/O as/O well/O as/O the/O in/O vitro/O reticulocyte/O lysate/O translation/O product/O ,/O comigrated/O with/O the/O purified/O 37/O -/O kDa/O protein/O on/O sodium/O dodecyl/O sulfate/O -/O polyacrylamide/O gels/O ./O
In/O addition/O ,/O this/O kinase/O is/O well/O conserved/O evolutionarily/O ,/O ubiquitously/O expressed/O ,/O and/O its/O genes/O map/O to/O a/O position/O on/O human/O chromosome/O 1/O frequently/O deleted/O in/O the/O late/O stages/O of/O tumorigenesis/O ./O
Deletion/O analysis/O of/O the/O ICL1/I promoter/I led/O to/O the/O identification/O of/O an/O upstream/O activating/O sequence/O element/O ,/O UASICL1/O (/O 5/O '/O CATTCATCCG/O 3/O '),/O necessary/O and/O sufficient/O for/O conferring/O carbon/O source/O -/O dependent/O regulation/O on/O a/O heterologous/O reporter/O gene/O ./O
Interestingly/O ,/O the/O interaction/O of/O ZAP/I -/I 70/I with/O the/O motif/O was/O dependent/O on/O the/O presence/O of/O both/O ZAP/I -/I 70/I SH2/I domains/I and/O both/O of/O the/O tyrosine/O residues/O in/O the/O motif/O ,/O suggesting/O that/O ZAP/I -/I 70/I interacts/O with/O two/O phosphotyrosine/O residues/O and/O that/O the/O binding/O of/O the/O two/O SH2/I domains/I is/O cooperative/O ./O
PRL/I -/I 1/I is/O able/O to/O dephosphorylate/O phosphotyrosine/O substrates/O ,/O and/O mutation/O of/O the/O active/O -/O site/O cysteine/O residue/O abolishes/O this/O activity/O ./O
In/O Mv1Lu/O lung/O epithelial/O cells/O ,/O ActR/I -/I IB/I and/O T/I beta/I R/I -/I I/I signal/O a/O common/O set/O of/O growth/O -/O inhibitory/O and/O transcriptional/O responses/O in/O association/O with/O their/O corresponding/O ligands/O and/O type/I II/I receptors/I ./O
50/O kDa/O and/O 130/O -/O 170/O kDa/O were/O detected/O ./O
H/O -/O 7/O ,/O which/O specifically/O ,/O although/O weakly/O ,/O inhibited/O PKC/I activation/O ,/O had/O no/O effect/O on/O tyrosine/O phosphorylation/O and/O PtdIns/O (/O 3/O ,/O 4/O )/O P2/O production/O ./O
The/O effects/O of/O systemic/O glucose/O concentration/O on/O brain/O metabolism/O following/O repeated/O brain/O ischemia/O ./O
This/O strategy/O was/O used/O to/O place/O both/O the/O Tn903/I neo/I gene/I and/O the/O Rhodosporidium/I toruloides/I phenylalanine/I ammonia/I lyase/I (/O PAL/I )-/O encoding/O gene/O under/O the/O transcriptional/O control/O of/O pPGK/I ::/O REP2/I ./O
In/O the/O case/O of/O congenital/O protein/I C/I deficiency/O ,/O vitamin/O K/O antagonists/O must/O be/O started/O cautiously/O due/O to/O the/O risk/O of/O skin/O necrosis/O ./O
A/O -/O 69/O -/O year/O -/O old/O patient/O with/O postoperative/O small/O -/O bowel/O obstruction/O underwent/O laparotomy/O three/O times/O ./O
On/O physical/O examination/O a/O mild/O symmetrical/O polyarthritis/O of/O small/O and/O large/O joints/O was/O seen/O ./O
In/O addition/O ,/O we/O observe/O that/O the/O hUBF/I -/I promoter/I interaction/O is/O highly/O sensitive/O to/O the/O antagonistic/O effects/O of/O cisplatin/O -/O DNA/O adducts/O ./O
We/O conclude/O that/O the/O SIMV/O is/O useful/O in/O weaning/O neonates/O from/O the/O ventilator/O ./O
VP/O -/O 16/O ,/O ifosfamide/O and/O cisplatin/O (/O VIP/O )/O for/O extensive/O small/O cell/O lung/O cancer/O ./O
A/O total/O of/O 7/O (/O 4/O males/O and/O 3/O females/O )/O patients/O were/O included/O in/O this/O retrospective/O study/O to/O determine/O the/O sensitivity/O of/O radioimmunoscintigraphy/O with/O I/O -/O 131/O labeled/O anti/I CEA/I //O CA/I 19/I -/I 9/I monoclonal/O antibodies/O ./O
Simultaneous/O ,/O bilateral/O and/O permanent/O ventilation/O with/O a/O diaphragm/O pacing/O in/O childhood/O :/O the/O implantation/O technique/O and/O indications/O
A/O genomic/O clone/O for/O the/O cyc07/I gene/I ,/O which/O is/O expressed/O specifically/O at/O the/O S/O phase/O during/O the/O cell/O cycle/O in/O synchronous/O cultures/O of/O periwinkle/O (/O Catharanthus/O roseus/O )/O cells/O ,/O was/O isolated/O ./O
CONCLUSIONS/O :/O Translocation/O of/O bacteria/O or/O endotoxin/O from/O the/O gastrointestinal/O tract/O into/O the/O bloodstream/O has/O been/O noted/O in/O animal/O experiments/O ;/O however/O ,/O translocation/O was/O not/O detected/O in/O our/O patients/O with/O hemorrhagic/O shock/O ./O
The/O pyrR/I and/O pyrP/I genes/I encoded/O polypeptides/O with/O calculated/O molecular/O masses/O of/O 19/O ./O 9/O and/O 45/O ./O 2/O kDa/O ,/O respectively/O ./O
Southern/O blotting/O analysis/O implied/O the/O occurrence/O of/O multiple/O COXVb/I genes/I in/O the/O rat/O genome/O ./O
Acylation/O with/O the/O palmitate/O analog/O was/O prevented/O when/O Gly/O -/O 2/O was/O mutated/O to/O alanine/O ,/O implying/O that/O N/O -/O myristylation/O is/O required/O for/O palmitylation/O ,/O and/O when/O either/O Cys/O -/O 3/O or/O Cys/O -/O 6/O was/O mutated/O to/O serine/O ./O
Subunit/O composition/O and/O domain/O structure/O of/O the/O Spo0A/I sporulation/I transcription/I factor/I of/I Bacillus/I subtilis/I ./O
Electrophoretic/O mobility/O shift/O analysis/O indicates/O that/O NF/I -/I IL/I -/I 6/I ,/O as/O well/O as/O other/O related/O members/O of/O this/O family/O ,/O bind/O specifically/O to/O the/O NF/I -/I IL/I -/I 6/I site/O in/O the/O IL/I -/I 8/I promoter/I ./O
BYV/O ,/O citrus/O tristeza/O virus/O (/O CTV/O ),/O beet/O yellow/O stunt/O virus/O (/O BYSV/O )/O and/O carnation/O necrotic/O fleck/O virus/O templates/O produced/O 1/O kb/O amplification/O products/O ,/O which/O were/O shown/O by/O sequencing/O to/O represent/O fragments/O of/O the/O respective/O HSP70/I genes/I ./O
To/O identify/O the/O precise/O location/O of/O the/O phosphorylation/O site/O on/O the/O 64/O -/O kDa/O protein/O ,/O a/O step/O -/O by/O -/O step/O mutagenesis/O procedures/O was/O followed/O ./O
The/O p53/I tumor/I suppressor/I gene/I product/I ,/O a/O sequence/O -/O specific/O DNA/O -/O binding/O protein/O ,/O has/O been/O shown/O to/O act/O as/O a/O transcriptional/O activator/O and/O repressor/O both/O in/O vitro/O and/O in/O vivo/O ./O
Mutational/O analysis/O of/O chromosomal/O segment/O 64AB/O ,/O a/O region/O containing/O the/O glutamic/I acid/I decarboxylase/I gene/I ./O
Rearrangements/O of/O the/O NFKB2/I gene/I are/O associated/O with/O lymphoid/O malignancies/O ,/O but/O the/O functional/O significance/O of/O these/O alterations/O is/O not/O known/O ./O
Cloning/O and/O sequencing/O of/O the/O corresponding/O cDNAs/O indicates/O that/O ,/O via/O alternative/O splicing/O ,/O the/O rearranged/O gene/O codes/O for/O two/O proteins/O of/O 84/O and/O 85/O kD/O (/O p84/I //I 85/I )/O which/O retain/O the/O DNA/O -/O binding/O rel/I domain/I and/O the/O first/O five/O ankyrin/I repeats/O ,/O but/O have/O lost/O their/O carboxy/O -/O terminus/O including/O the/O seventh/O ankyrin/I repeat/O ./O
Transient/O co/O -/O transfection/O assays/O involving/O NFKB2/I expression/O vectors/O and/O kappa/I B/I -/O driven/O reporter/O plasmids/O indicate/O that/O NFKB2/I p85/I has/O lost/O the/O transcriptional/O repressor/O functions/O typical/O of/O normal/O NFKB2/I p52/I ./O
Also/O ,/O HR21ap/I as/O well/O as/O HR21Xap/I are/O specific/O in/O their/O inhibition/O of/O Sp1/I binding/O ./O
Intravenous/O antibiotic/O therapy/O in/O cystic/O fibrosis/O :/O in/O hospital/O or/O at/O home/O ?/O
Open/O reading/O frames/O in/O a/O 4556/O nucleotide/O sequence/O within/O MDV/I -/I 1/I BamHI/I -/I D/I DNA/I fragment/I :/O evidence/O for/O splicing/O of/O mRNA/O from/O a/O new/O viral/O glycoprotein/O gene/O ./O
The/O ns2/I gene/I comprises/O an/O open/O reading/O frame/O (/O ORF/O )/O encoding/O a/O putative/O nonstructural/O (/O ns/O )/O protein/O of/O 279/O amino/O acids/O with/O a/O predicted/O molecular/O mass/O of/O 32/O -/O kDa/O ./O
Co/O -/O transfection/O of/O a/O tat/I expressing/O plasmid/O with/O these/O viruses/O containing/O the/O tat/I ORF/I mutations/O resulted/O in/O higher/O levels/O of/O virus/O production/O demonstrating/O that/O the/O effects/O of/O both/O mutants/O are/O tat/I specific/O ./O
Analysis/O of/O the/O gag/I and/O rev/I proteins/I in/O the/O transfected/O cells/O demonstrated/O that/O these/O proteins/O were/O not/O detectable/O in/O cells/O transfected/O with/O the/O tat/I mutants/I but/O could/O be/O readily/O detected/O when/O the/O mutations/O were/O complemented/O in/O trans/O with/O a/O tat/I expression/O vector/O ./O
The/O hydrophobicity/O profile/O of/O the/O methyltransferase/O reveals/O the/O presence/O of/O at/O least/O five/O potential/O transmembrane/O domains/O ./O
Measurement/O of/O SaO2/O at/O moderate/O altitude/O can/O be/O helpful/O in/O the/O care/O of/O both/O healthy/O and/O ill/O newborns/O or/O infants/O ./O
To/O determine/O whether/O the/O excess/O prevalence/O of/O human/O immunodeficiency/O virus/O type/O 1/O (/O HIV/O -/O 1/O )/O infection/O in/O US/O black/O and/O Hispanic/O homosexual/O men/O relative/O to/O white/O men/O can/O be/O explained/O by/O differences/O in/O sociodemographic/O factors/O ,/O history/O of/O sexually/O transmitted/O diseases/O ,/O or/O sexual/O and/O drug/O -/O use/O behaviors/O ,/O the/O authors/O conducted/O a/O cross/O -/O sectional/O analysis/O of/O baseline/O HIV/O -/O 1/O seroprevalence/O and/O HIV/O -/O 1/O risk/O factors/O among/O 4/O ,/O 475/O non/O -/O Hispanic/O white/O ,/O 234/O Hispanic/O white/O ,/O and/O 194/O black/O homosexual/O men/O from/O four/O centers/O in/O the/O United/O States/O (/O Baltimore/O //O Washington/O ,/O DC/O ,/O Pittsburgh/O ,/O Chicago/O ,/O and/O Los/O Angeles/O )./O
The/O patients/O in/O one/O group/O had/O intrauterine/O catheters/O inserted/O and/O oxytocin/I was/O titrated/O to/O achieve/O the/O 75th/O percentile/O of/O uterine/O activity/O observed/O in/O spontaneous/O normal/O labour/O according/O to/O parity/O ./O
Continued/O development/O of/O the/O rat/O conditioning/O paradigm/O is/O especially/O warranted/O because/O of/O the/O ability/O to/O record/O sympathetic/O nerve/O activity/O in/O intact/O ,/O awake/O subjects/O and/O the/O large/O number/O of/O readily/O available/O genetic/O strains/O ,/O which/O model/O human/O pathological/O states/O ./O
The/O ultrastructure/O of/O retinal/O vessels/O was/O examined/O in/O three/O eyes/O from/O diabetic/O patients/O and/O two/O eyes/O from/O control/O subjects/O ./O
The/O regulatory/O region/O also/O has/O a/O sequence/O similar/O to/O the/O binding/O site/O for/O a/O liver/O -/O specific/O transcription/O factor/O ,/O hepatocyte/I nuclear/I factor/I 1/I (/O HNF/I -/I 1/I ),/O at/O positions/O -/O 120/O to/O -/O 132/O ./O
Thus/O ,/O we/O have/O identified/O a/O GRE/O sufficient/O to/O account/O for/O full/O glucocorticoid/O inducibility/O and/O an/O HNF/I -/I 1/I site/I close/O to/O the/O promoter/O that/O are/O major/O determinants/O of/O transcriptional/O control/O of/O the/O Xenopus/I fibrinogen/I B/I beta/I subunit/I gene/I in/O cells/O from/O normal/O liver/O tissue/O ./O
Acad/O ./O
The/O PRB/I -/I 1b/I gene/I encodes/O for/O a/O basic/O -/O type/O component/O of/O the/O pathogenesis/O -/O related/O PR/I -/I 1/I protein/I family/I ./O
Replacement/O of/O the/O CRE/O with/O a/O second/O copy/O of/O the/O AP/I -/I 1/I site/I results/O in/O a/O level/O of/O transcriptional/O activity/O comparable/O with/O that/O of/O the/O wild/O -/O type/O sequence/O ,/O but/O replacement/O of/O the/O AP/I -/I 1/I site/I with/O a/O CRE/O abolishes/O activity/O ./O
The/O T/I -/I cyt/I promoter/I ,/O although/O of/O bacterial/O origin/O is/O active/O in/O planta/O and/O the/O 30/I bp/I cyt/I -/I 1/I element/I is/O located/O within/O a/O region/O that/O is/O essential/O for/O T/I -/I cyt/I promotor/I activity/O in/O leaf/O ,/O stem/O and/O root/O cells/O of/O tobacco/O plants/O ./O
Reviewing/O manuscripts/O :/O developing/O an/O efficient/O system/O ./O
We/O suggest/O that/O CT/O scan/O be/O preferable/O in/O diagnosis/O of/O tumors/O in/O that/O area/O ./O
SIN/O -/O 1/O had/O no/O influence/O on/O either/O the/O ischemic/O parameters/O in/O the/O surface/O electrocardiogram/O (/O ECG/O )/O or/O the/O intracoronary/O ECG/O ./O
Effect/O of/O aging/O on/O respiratory/O skeletal/O muscles/O ./O
Two/O BASIC/O computer/O programs/O using/O logit/O transformation/O for/O the/O analysis/O of/O S/O -/O shaped/O curves/O are/O presented/O ./O
The/O yeast/I SSS1/I gene/I is/O essential/O for/O secretory/O protein/O translocation/O and/O encodes/O a/O conserved/O protein/O of/O the/O endoplasmic/O reticulum/O ./O
The/O lengths/O of/O the/O complete/O polypeptide/O chain/O of/O the/O recombinant/O enzyme/O and/O its/O transit/O peptide/O are/O 388/O and/O 53/O residues/O ,/O respectively/O ./O
The/O absence/O of/O H4PteGlun/O bound/O to/O the/O T/I protein/I in/O our/O experimental/O conditions/O demonstrates/O that/O H4PteGlun/O is/O not/O covalently/O linked/O to/O the/O T/I protein/I ./O
TATA/O and/O CCAAT/O boxes/O are/O located/O 34/O -/O bp/O and/O 68/O -/O bp/O ,/O respectively/O ,/O upstream/O of/O the/O transcription/O start/O site/O ,/O the/O 5/O '-/O untranslated/O leader/O is/O 78/O nucleotides/O long/O ,/O and/O the/O intronless/O gene/O has/O at/O least/O two/O different/O polyadenylation/O sites/O ./O
GGS1/I is/O the/O same/O gene/O as/O TPS1/I which/O was/O identified/O as/O encoding/O a/O subunit/O of/O the/O trehalose/I -/I 6/I -/I phosphate/I synthase/I //I phosphatase/I complex/I and/O it/O is/O allelic/O to/O the/O fdp1/I ,/O byp1/I ,/O glc6/I and/O cif1/O mutations/O ./O
We/O also/O compared/O the/O sequence/O with/O the/O partly/O homologous/O products/O of/O the/O S/O ./O cerevisiae/O genes/O TPS2/I and/O TSL1/I which/O code/O for/O the/O larger/O subunits/O of/O the/O trehalose/I synthase/I complex/I and/O with/O a/O TSL1/I homologue/I ,/O TPS3/I ,/O of/O unknown/O function/O ./O
Stroop/O interference/O :/O aging/O effects/O assessed/O with/O the/O Stroop/O Color/O -/O Word/O Test/O ./O
Stimulation/O of/O [/O 3H/O ]/O PA/O production/O upon/O CD3/I cross/O -/O linking/O was/O 77/O %/O lower/O in/O permeabilized/O CD45/I -/I cells/O than/O in/O CD45/I +/I cells/O ,/O consistent/O with/O the/O reduced/O activity/O of/O p59fyn/I in/O CD45/I -/I cells/O ./O
CONCLUSION/O :/O The/O study/O demonstrates/O that/O transvaginal/O ultrasonography/O has/O an/O efficiency/O of/O 88/O %/O in/O differentiating/O endometriomas/O from/O other/O ovarian/O masses/O with/O a/O specificity/O of/O 90/O %./O
Genomic/O Southern/O blot/O analysis/O of/O rat/I EFIA/I (/O gene/O encoding/O enhancer/I factor/I I/I subunit/I A/I )/O reveals/O a/O complex/O band/O pattern/O when/O cDNA/O subfragment/O probes/O are/O used/O ./O
The/O effect/O of/O ibopamine/O and/O furosemide/O in/O 130/O patients/O with/O NYHA/O Class/O I/O and/O II/O heart/O failure/O were/O studied/O in/O a/O parallel/O ,/O double/O -/O blind/O ,/O randomized/O placebo/O -/O controlled/O multi/O -/O centre/O trial/O ./O
The/O nit/I -/I 3/I gene/I of/I the/I filamentous/I fungus/I Neurospora/I crassa/I encodes/O nitrate/I reductase/I ,/O the/O enzyme/O which/O catalyzes/O the/O first/O step/O in/O nitrate/O assimilation/O ./O
Unfolding/O can/O be/O described/O by/O a/O two/O -/O state/O process/O since/O a/O ratio/O of/O delta/O Hcalorimetric/O to/O delta/O Hvan/O '/O t/O Hoff/O equals/O 0/O ./O 96/O ./O
A/O Dictyostelium/O transformant/O overexpressing/O DdPTPa/I does/O not/O develop/O normally/O ./O
This/O motif/O has/O been/O shown/O to/O mediate/O protein/O interactions/O in/O the/O case/O of/O ankyrin/I as/O well/O as/O several/O other/O repeat/O -/O bearing/O proteins/O ./O
[/I Ala85/I ]/I Dk/I (/I 69/I -/I 85/I )/I retains/O full/O biological/O activity/O ./O
We/O postulate/O that/O CaM/I binding/O by/O HIV/I envelope/I proteins/I is/O likely/O to/O exert/O diverse/O modulatory/O effects/O ,/O and/O the/O mechanism/O for/O HIV/O -/O induced/O cytotoxicity/O may/O involve/O ,/O in/O part/O ,/O inhibition/O of/O CaM/I -/O regulated/O cellular/O functions/O ./O
There/O was/O no/O apparent/O effect/O of/O growth/O temperature/O on/O the/O steady/O -/O state/O levels/O of/O fad7/I mRNA/I in/O wild/O type/O plants/O ./O
The/O major/O myosin/I -/I binding/I domain/I of/O skeletal/I muscle/I MyBP/I -/I C/I (/O C/I protein/I )/O resides/O in/O the/O COOH/O -/O terminal/O ,/O immunoglobulin/I C2/I motif/I ./O
A/O second/O important/O molecule/O in/O TCR/I signal/O transduction/O is/O the/O guanine/I nucleotide/I binding/I protein/I ,/O p21ras/I ,/O which/O is/O coupled/O to/O the/O TCR/I by/O a/O protein/I tyrosine/I kinase/I dependent/O mechanism/O ./O
Our/O results/O indicate/O that/O periseizure/O lipid/O accumulation/O is/O related/O to/O cortical/O oxygenation/O ./O
We/O conclude/O that/O the/O QLMI/O questionnaire/O has/O good/O potential/O as/O an/O instrument/O for/O assessing/O QL/O in/O post/O -/O AMI/O patients/O and/O that/O it/O can/O be/O successfully/O self/O -/O administered/O ./O
Most/O smokers/O would/O prefer/O to/O quit/O smoking/O on/O their/O own/O ./O
The/O inhibitory/O response/O to/O taps/O is/O essentially/O a/O protective/O reflex/O which/O probably/O serves/O to/O reduce/O the/O activity/O of/O the/O jaw/O -/O closing/O muscles/O when/O one/O bites/O unexpectedly/O on/O hard/O objects/O ./O
The/O action/O of/O nef/I was/O specific/O to/O the/O LTR/O ,/O as/O expression/O of/O nef/I had/O no/O effect/O on/O the/O activity/O of/O the/O simian/O virus/O 40/O ,/O c/I -/I fms/I ,/O urokinase/I plasminogen/I activator/I ,/O or/O type/I 5/I acid/I phosphatase/I promoter/I ./O trans/O -/O activating/O activity/O was/O also/O manifested/O by/O a/O frameshift/O mutant/O expressing/O only/O the/O first/O 35/O amino/O acids/O of/O the/O protein/O ./O
The/O product/O of/O the/O vpr/I open/I reading/I frame/I of/I human/I immunodeficiency/I virus/I type/I 1/I (/I HIV/I -/I 1/I )/I is/O a/O 15/O -/O kDa/O ,/O arginine/O -/O rich/O protein/O that/O is/O present/O in/O virions/O in/O molar/O quantities/O equivalent/O to/O that/O of/O Gag/I ./O
The/O recombinant/I vaccinia/I virus/I -/I expressed/I mutant/I P1/I polyproteins/I were/O analyzed/O for/O proteolytic/O processing/O defects/O in/O cells/O coinfected/O with/O a/O recombinant/O vaccinia/O virus/O (/O VVP3/O )/O that/O expresses/O the/O poliovirus/I 3CD/I protease/I and/O for/O processing/O and/O assembly/O defects/O by/O using/O a/O trans/O complementation/O system/O in/O which/O P1/I -/O expressing/O recombinant/O vaccinia/O viruses/O provide/O capsid/I precursor/I to/O a/O defective/O poliovirus/O genome/O that/O does/O not/O express/O functional/O capsid/I proteins/I (/O D/O ./O
In/O contrast/O ,/O capsid/I proteins/I derived/O from/O the/O P1/I precursor/I with/O a/O valine/O substitution/O at/O the/O amino/O terminus/O of/O VP1/I (/O VP1/I -/I G001V/I )/O assembled/O empty/O capsid/O particles/O but/O were/O deficient/O in/O assembling/O RNA/O -/O containing/O virions/O ./O
RESULTS/O :/O In/O an/O 18/O moth/O period/O and/O out/O of/O a/O total/O of/O 284/O positive/O blood/O cultures/O (/O 154/O significant/O isolations/O )/O 14/O episodes/O of/O bacteremia/O by/O M/O ./O tuberculosis/O were/O studied/O in/O 12/O prison/O patients/O coinfected/O by/O the/O human/O immunodeficiency/O virus/O with/O associated/O severe/O immunosuppression/O (/O mean/O of/O CD4/I =/O 0/O ./O 068/O x/O 10/O (/O 9/O )//O l/O )./O
Acid/O instilled/O on/O the/O larynx/O of/O maturing/O rabbits/O resulted/O in/O significant/O obstructive/O ,/O central/O ,/O and/O mixed/O apnea/O ./O
By/O using/O total/O -/O protein/O extracts/O from/O mycelia/O grown/O under/O penicillin/O producing/O conditions/O we/O have/O detected/O a/O DNA/O -/O binding/O activity/O that/O specifically/O shifts/O a/O promoter/O fragment/O located/O between/O -/O 654/O and/O -/O 455/O (/O relative/O to/O IPNS/I tsp/I )./O
A/O series/O of/O 5/O '-/O deletions/O revealed/O that/O the/O fragment/O -/O 218/O to/O +/O 4/O from/O the/O TSS/O had/O the/O highest/O promoter/O activity/O ,/O nearly/O 1000/O -/O fold/O greater/O than/O the/O promoterless/O chloramphenicol/I acetyltransferase/I construct/I ./O
The/O lemdr1/I gene/I was/O cloned/O in/O the/O expression/O vector/O pALTNEO/O and/O transfected/O into/O wild/O -/O type/O L/O ./O enriettii/O and/O the/O resulting/O transfected/O cells/O were/O resistant/O to/O vinblastine/O but/O at/O lower/O levels/O than/O in/O the/O selected/O mutant/O cells/O ./O
The/O bioavailability/O of/O etodolac/O from/O capsules/O exposed/O to/O stressed/O conditions/O was/O compared/O in/O both/O dogs/O and/O humans/O to/O capsules/O stored/O at/O RT/O conditions/O ./O
Similar/O synergistic/O activation/O was/O observed/O in/O the/O IL/I -/I 8/I promoter/I ,/O which/O also/O contains/O both/O NF/I -/I IL6/I and/O NF/I -/I kappa/I B/I binding/I sites/I ./O
Notice/O of/O retraction/O ./O
No/O homology/O was/O found/O between/O the/O 36K/O protein/O and/O known/O structures/O of/O proteins/O ./O
We/O report/O an/O odd/O case/O of/O marked/O enlargement/O of/O suprapineal/O recess/O in/O a/O patient/O with/O triventricular/O hydrocephalus/O ./O
As/O regards/O lipid/O metabolism/O ,/O the/O mean/O values/O for/O total/O triglycerides/O ,/O cholesterol/O ,/O LDL/I -/I cholesterol/I and/O HDL/I -/I cholesterol/I seen/O at/O the/O end/O of/O five/O years/O of/O Norplant/O -/O 2/O rod/O use/O and/O six/O months/O postremoval/O were/O similar/O to/O the/O preinsertion/O mean/O ./O
At/O a/O PaCO2/O of/O 40/O mmHg/O ,/O baseline/O brain/O pHi/O measured/O 7/O ./O 03/O +/-/O 0/O ./O 04/O ,/O while/O regional/O cortical/O blood/O flow/O was/O 47/O ./O 0/O +/-/O 4/O ./O 3/O ml/O ./O 100/O g/O -/O 1/O ./O min/O -/O 1/O ./O
CPAP/O reduced/O isotime/O (/O defined/O as/O the/O last/O common/O minute/O of/O exercise/O )/O VO2/O and/O dyspnea/O in/O those/O patients/O with/O more/O severe/O lung/O disease/O ,/O but/O these/O values/O tended/O to/O increase/O slightly/O in/O the/O patients/O with/O only/O mild/O lung/O disease/O ./O
Effects/O of/O diltiazem/O on/O netilmicin/O -/O induced/O nephrotoxicity/O in/O rabbits/O ./O
Four/O forms/O of/O salmonellosis/O were/O recognised/O in/O feedlots/O and/O during/O transport/O by/O sea/O :/O septicaemic/O ,/O and/O acute/O ,/O subacute/O and/O chronic/O enteric/O ./O
About/O 20/O %/O of/O single/O -/O stranded/O DNA/O binding/O was/O observed/O in/O the/O presence/O of/O MgdTDP/O ,/O but/O none/O was/O detectable/O in/O the/O absence/O of/O nucleotides/O ./O
To/O our/O knowledge/O this/O is/O the/O first/O case/O in/O which/O a/O probable/O association/O between/O cholelithiasis/O and/O Wildervanck/O '/O s/O syndrome/O has/O been/O recorded/O ./O
Both/O 4/O ,/O 8/O -/O DiMeIQx/O and/O A/O alpha/O C/O were/O found/O at/O /O A/O and/O TS677/O ,/O 679/O -->/O A/O are/O inhibited/O by/O the/O T/I -/I antigen/I kinase/I ,/O as/O is/O wild/I -/I type/I T/I antigen/I ./O
The/O degree/O of/O hypoperfusion/O was/O slightly/O related/O to/O decrease/O in/O FEV1/O ./O 0/O %,/O V25/O and/O PaO2/O and/O increase/O in/O circulating/O blood/O volume/O and/O peripheral/O red/O blood/O cell/O counts/O ./O
Two/O patients/O were/O treated/O successfully/O with/O a/O combination/O of/O metronidazole/O (/O a/O tissue/O amoebicide/O )/O and/O diloxanide/O (/O a/O lumenal/O amoebicide/O )./O
We/O have/O identified/O in/O the/O 5/O '/O untranslated/O region/O of/O the/O Drosophila/I copia/I retrotransposon/I ,/O 3/O '/O to/O the/O left/O LTR/O ,/O a/O sequence/O for/O transcriptional/O regulation/O by/O homeoproteins/O ./O
In/O the/O present/O study/O ,/O lesions/O of/O the/O OPT/O complex/O (/O the/O thalamic/O source/O of/O afferents/O to/O IHA/O and/O HD/O )/O were/O found/O to/O have/O no/O effect/O on/O color/O -/O reversal/O learning/O performance/O ./O
The/O fourth/O dose/O produced/O favorable/O results/O (/O 66/O ./O 7/O %)/O in/O individuals/O with/O HB/I antibodies/I between/O 10/O and/O 100/O IU/O //O ml/O and/O unfavorable/O ones/O (/O 3/O ./O 8/O %)/O where/O the/O HB/I antibodies/I were/O below/O 10/O IU/O //O ml/O ./O
CONCLUSIONS/O :/O In/O our/O patients/O and/O within/O the/O range/O of/O treatment/O variables/O studied/O ,/O age/O ,/O Karnofsky/O index/O ,/O and/O graft/O -/O versus/O -/O host/O disease/O are/O the/O most/O important/O factors/O related/O with/O early/O mortality/O ./O
Nucleotide/O sequence/O analysis/O of/O the/O HA/I gene/I in/O these/O two/O mutants/O confirmed/O the/O HA/I -/I phenotype/O ./O
This/O intron/O occupies/O a/O conserved/O position/O corresponding/O to/O that/O of/O intron/O 1/O in/O the/O transit/O peptide/O region/O of/O chloroplast/I GAPDH/I genes/I (/O GapA/I and/O GapB/I )/O of/O higher/O plants/O ./O
The/O drug/O -/O resistant/O cell/O lines/O P388/O //O ADR/O //O 3/O and/O P388/O //O ADR/O //O 7/O express/O a/O shortened/O topo/I II/I alpha/I mRNA/I transcript/I in/O addition/O to/O the/O native/O transcript/O present/O in/O the/O drug/O -/O sensitive/O P388/O //O 4/O cell/O line/O ./O
Using/O a/O 3/O '-/O rapid/O amplification/O of/O cDNA/O ends/O strategy/O ,/O we/O have/O cloned/O cDNAs/O representing/O the/O 3/O '-/O termini/O of/O both/O the/O native/O and/O mutant/O transcripts/O from/O both/O P388/O //O ADR/O //O 3/O and/O P388/O //O ADR/O //O 7/O cells/O ./O
The/O phi/I AP3/I factor/I is/O a/O nuclear/O phosphoprotein/O ;/O the/O extent/O of/O its/O phosphorylation/O is/O regulated/O during/O the/O cell/O cycle/O ./O
Similarly/O ,/O the/O N/O -/O terminal/O cytoplasmic/O domain/O of/O the/O latent/I membrane/I protein/I 2A/I (/O LMP2A/I )/O of/O the/O Epstein/O -/O Barr/O virus/O (/O EBV/O )/O contains/O a/O single/O copy/O of/O the/O Tyr/O -/O X/O -/O X/O -/O Leu/O //O Ile/O -/O containing/O motif/O which/O could/O play/O a/O critical/O role/O in/O B/O cell/O transformation/O ./O
The/O functional/O homology/O of/O Cwg2/I with/O Cdc43/I ,/O which/O has/O been/O implicated/O in/O the/O control/O of/O cell/O polarity/O ,/O suggests/O a/O link/O between/O two/O morphogenetic/O events/O such/O as/O establishment/O of/O cell/O polarity/O and/O cell/O wall/O biosynthesis/O ./O
Molecular/O cloning/O of/O a/O P/I -/I type/I ATPase/I gene/I from/O the/O cyanobacterium/O Synechocystis/O sp/O ./O
The/O cloning/O of/O PTR2/I represents/O the/O first/O example/O of/O the/O molecular/O genetic/O characterization/O of/O a/O eucaryotic/O peptide/O transport/O gene/O ./O
By/O using/O the/O full/O -/O length/O cytoplasmic/O domain/O and/O mutants/O with/O progressive/O carboxy/O -/O terminal/O deletions/O ,/O internal/O deletions/O ,/O or/O point/O mutations/O ,/O we/O identified/O the/O first/O 150/O amino/O acid/O residues/O of/O LIFR/I as/O the/O minimal/O region/O necessary/O for/O signaling/O ./O
To/O examine/O the/O biochemical/O basis/O of/O the/O end/O joining/O ,/O nuclear/O extracts/O were/O prepared/O from/O a/O wide/O variety/O of/O mammalian/O cell/O lines/O and/O tested/O for/O their/O ability/O to/O join/O test/O plasmid/O substrates/O ./O
These/O data/O indicate/O that/O the/O largest/O subunit/O of/O RNA/I polymerase/I II/I and/O TFIIB/I are/O important/O determinants/O of/O transcription/O start/O site/O selection/O in/O S/O ./O cerevisiae/O and/O suggest/O that/O this/O function/O might/O be/O conferred/O by/O interaction/O between/O these/O two/O proteins/O ./O
Recombinant/O expression/O of/O a/O chimeric/O EGFR/I //O ErbB/I -/I 3/I receptor/I in/O NIH/O 3T3/O fibroblasts/O allowed/O us/O to/O investigate/O cytoplasmic/O events/O associated/O with/O ErbB/I -/I 3/I signal/O transduction/O upon/O ligand/O activation/O ./O
Oligonucleotide/O competitors/O were/O used/O to/O evaluate/O the/O accessibility/O of/O the/O TATA/O -/O binding/O site/O in/O TIF/I -/I IB/I ,/O TFIID/I ,/O and/O TFIIIB/I ./O
The/O 227/O -/O to/O -/O 239/O region/O blocked/O ADR1/I activity/O independently/O of/O the/O TAD/I present/O on/O ADR1/I ,/O ADR1/I DNA/O binding/O ,/O and/O specific/O ADH2/I promoter/I sequences/I ./O
Analysis/O of/O strains/O harboring/O an/O mds1/I null/I mutation/I demonstrates/O that/O MDS1/I is/O not/O essential/O during/O normal/O vegetative/O growth/O but/O appears/O to/O be/O required/O for/O meiosis/O ./O
TGF/I beta/I 1/I expression/O is/O largely/O governed/O by/O three/O AP/I -/I 1/I binding/I sites/I located/O in/O two/O different/O promoters/O of/O this/O gene/O ./O
Val/O -->/O Ala/O mutations/O selectively/O alter/O helix/O -/O helix/O packing/O in/O the/O transmembrane/O segment/O of/O phage/I M13/I coat/I protein/I ./O
Strategic/O change/O in/O the/O NHS/O ./O
A/O much/O less/O expensive/O solution/O than/O UW/O ,/O containing/O only/O K/O (+)-/O lactobionate/O ,/O KH2PO4/O ,/O MgSO4/O and/O raffinose/O ,/O can/O be/O used/O successfully/O for/O preservation/O of/O rat/O hepatocytes/O for/O 24/O hr/O for/O drug/O transport/O studies/O ./O
Repeated/O administration/O of/O GRg2/O 20/O mg/O //O kg/O i/O ./O p/O ./O significantly/O improved/O the/O CYP/O -/O induced/O recognitional/O deficits/O by/O increasing/O the/O CYP/O -/O decreased/O rate/O from/O 55/O ./O 8/O +/-/O 9/O ./O 6/O to/O 80/O ./O 8/O +/-/O 4/O ./O 2/O in/O d/O 3/O learning/O acquisition/O (/O F/O (/O 1/O ,/O 14/O )/O =/O 5/O ./O 6/O ,/O p/O /O or/O =/O 75/O %/O of/O the/O total/O premature/O ventricular/O contractions/O in/O all/O patients/O who/O had/O both/O use/O -/O dependent/O QRS/O prolongation/O and/O reverse/O use/O -/O dependent/O QT/O prolongation/O ,/O in/O 79/O %/O of/O patients/O with/O use/O -/O dependent/O QRS/O prolongation/O alone/O ,/O in/O 70/O %/O with/O reverse/O use/O -/O dependent/O QT/O prolongation/O alone/O ,/O and/O in/O 11/O %/O with/O neither/O use/O -/O dependent/O QRS/O prolongation/O nor/O reverse/O use/O -/O dependent/O QT/O prolongation/O ./O
Losses/O during/O the/O complete/O procedure/O are/O corrected/O for/O using/O radioactive/O estrogen/O conjugates/O during/O the/O first/O steps/O and/O later/O by/O adding/O deuterated/O internal/O standards/O of/O all/O compounds/O measured/O (/O matairesinol/O ,/O enterodiol/O ,/O enterolactone/O ,/O daidzein/O ,/O O/O -/O desmethylangolensin/O ,/O equol/O ,/O and/O genistein/O )./O
IE2/I -/O IE2/I interactions/O were/O mapped/O to/O a/O domain/O containing/O a/O putative/O helix/O -/O turn/O -/O helix/O motif/O located/O near/O the/O C/O terminus/O of/O IE2/I ,/O between/O amino/O acids/O 456/O and/O 539/O ./O
The/O Sp1/I region/I ,/O however/O ,/O is/O converted/O to/O a/O functionally/O strong/O TRE/O by/O the/O viral/I tat/I factor/I ./O
Precipitation/O using/O GST/I fusion/I proteins/I containing/O Fyn/I SH2/I ,/O SH3/I ,/O and/O SH2/I //O SH3/I domains/O revealed/O that/O PI/I 3/I -/I kinase/I bound/O principally/O to/O the/O SH3/I domain/I of/O Fyn/I ./O
A/O sheep/O testicular/O cDNA/O library/O constructed/O in/O pcDNA1/O vector/O was/O screened/O with/O a/O probe/O generated/O by/O polymerase/O chain/O reaction/O (/O PCR/O )/O and/O corresponding/O to/O a/O 1/O ./O 6/O kb/O fragment/O of/O the/O rat/I luteinizing/I hormone/I receptor/I cDNA/I ./O
Two/O putative/O Rev/I proteins/I with/O apparent/O molecular/O masses/O of/O 18/O and/O 16/O kDa/O were/O expressed/O by/O p2/I //I 2/I and/O p176/I ,/O while/O p20/I expressed/O only/O a/O 16/O -/O kDa/O species/O ./O
Three/O group/O 1/O patients/O developed/O CMV/O disease/O ;/O 1/O group/O 2/O patient/O developed/O CMV/O hepatitis/O ./O
The/O ability/O of/O spt2/I mutations/I to/O suppress/O the/O transcriptional/O interference/O caused/O by/O the/O delta/I promoter/I insertion/I his/I -/I 4/I -/I 912/I delta/I correlates/O with/O an/O increase/O in/O wild/I -/I type/I HIS4/I mRNA/I levels/O ./O
Nuclear/O localization/O and/O protein/O sequence/O similarities/O suggested/O that/O the/O SPT2/I //O SIN1/I protein/O may/O be/O related/O to/O the/O nonhistone/I chromosomal/I protein/I HMG1/I ./O
The/O conserved/O ninth/O C/O -/O terminal/O heptad/O in/O thyroid/O hormone/O and/O retinoic/I acid/I receptors/I mediates/O diverse/O responses/O by/O affecting/O heterodimer/O but/O not/O homodimer/O formation/O ./O
Genetic/O interactions/O between/O BCK2/I and/O other/O pathway/O components/O suggested/O that/O BCK2/I functions/O on/O a/O common/O pathway/O branch/O with/O PPZ1/I and/O PPZ2/I ./O
Steroidogenic/I factor/I 1/I ,/O an/O orphan/I nuclear/I receptor/I ,/O regulates/O the/O expression/O of/O the/O rat/I aromatase/I gene/I in/O gonadal/O tissues/O ./O
To/O study/O the/O functional/O differences/O between/O cutaneous/O HPV5/O and/O HPV8/O E7s/I and/O genital/I HPV16/I E7/I ,/O we/O cloned/O each/O of/O the/O E7/I open/O reading/O frames/O and/O tested/O their/O immortalizing/O and/O transforming/O activities/O ,/O the/O binding/O ability/O of/O their/O products/O with/O retinoblastoma/I protein/I (/O RB/I )/O and/O their/O complementation/O activity/O of/O a/O RB/I -/I nonbinding/I adenovirus/I E1A/I mutant/I ./O
The/O rhaB/I transcription/I start/I site/I was/O mapped/O to/O -/O 24/O relative/O to/O the/O start/O of/O translation/O ./O
Several/O lines/O of/O evidence/O demonstrate/O that/O this/O growth/O inhibition/O requires/O active/O PKA/I subunits/I and/O cAMP/O :/O (/O i/O )/O this/O phenotype/O is/O dependent/O on/O cAMP/O since/O it/O is/O not/O seen/O in/O a/O strain/O lacking/O adenylyl/I cyclase/I activity/O ,/O but/O the/O growth/O rate/O of/O these/O transformants/O is/O slower/O when/O exogenous/O cAMP/O is/O added/O ;/O (/O ii/O )/O normal/O growth/O occurs/O when/O wild/O -/O type/O RI/I cDNA/O is/O replaced/O by/O a/O mutant/I RI/I cDNA/I encoding/O a/O RI/I protein/I with/O reduced/O cAMP/O binding/O ;/O and/O (/O iii/O )/O the/O growth/O -/O inhibited/O phenotype/O of/O the/O transformed/O BL21/O (/O DE3/O )/O cells/O requires/O soluble/O ,/O active/O C/I alpha/I protein/I ./O
Liu/O ,/O B/O ./O
BCR/I -/O ABL/I and/O v/I -/I abl/I oncogenes/I induce/O distinct/O patterns/O of/O thymic/O lymphoma/O involving/O different/O lymphocyte/O subsets/O ./O
These/O experiments/O confirm/O that/O the/O 6/O -/O S/O liganded/O form/O of/O the/O receptor/O identified/O in/O nuclear/O extracts/O of/O cells/O treated/O with/O 2/O ,/O 3/O ,/O 7/O ,/O 8/O -/O tetrachlorodibenzo/O -/O p/O -/O dioxin/O (/O TCDD/O )/O contains/O the/O Ah/I receptor/I protein/I and/O ARNT/I but/O not/O the/O 90/I -/I kDa/I heat/I shock/I protein/I ./O
LDL/I cholesterol/I decreased/O from/O 4/O ./O 74/O +/-/O 0/O ./O 87/O to/O 3/O ./O 78/O +/-/O 0/O ./O 78/O mmol/O //O l/O after/O 8/O weeks/O on/O simvastatin/O (/O P/O /O Pro/O substitution/O causes/O a/O reduction/O in/O the/O acylation/O of/O some/O but/O not/O all/O protein/O substrates/O ./O
These/O CTD/I kinases/I ,/O designated/O CTDK1/I and/O CTDK2/I ,/O are/O fractionated/O by/O chromatography/O on/O Mono/O Q/O ./O
Instead/O ,/O mRNA/O of/O 2/O ./O 0/O and/O 2/O ./O 8/O kb/O are/O detected/O in/O varying/O abundance/O ./O
Previously/O ,/O we/O identified/O a/O 51/O -/O bp/O promoter/O fragment/O ,/O oligo31/O //O 32/O ,/O which/O conferred/O heat/O shock/O inducibility/O on/O the/O heterologous/O CYC1/I -/O lacZ/I reporter/O gene/O in/O S/O ./O cerevisiae/O (/O N/O ./O
The/O sequence/O of/O the/O HIR1/I gene/I predicts/O an/O 88/O -/O kDa/O protein/O with/O three/O repeats/O of/O a/O motif/O found/O in/O the/O G/I beta/I subunit/I of/O retinal/I transducin/I and/O in/O a/O yeast/O transcriptional/O repressor/O ,/O Tup1/I ./O
All/O of/O these/O data/O suggest/O that/O replication/O of/O UV/O -/O damaged/O templates/O occurs/O in/O vitro/O as/O it/O does/O in/O vivo/O and/O that/O this/O replication/O results/O in/O mutation/O fixation/O ./O
To/O identify/O factors/O that/O may/O modify/O the/O heterosexual/O transmission/O of/O human/O T/O cell/O leukemia/O //O lymphoma/O virus/O type/O I/O (/O HTLV/O -/O I/O ),/O 534/O married/O couples/O enrolled/O in/O the/O Miyazaki/O Cohort/O Study/O between/O November/O 1984/O and/O April/O 1989/O were/O studied/O :/O 95/O husband/O HTLV/O -/O I/O -/O seropositive/O (/O H/O +)//O wife/O seropositive/O (/O W/O +),/O 33/O H/O +//O W/O -,/O 64/O H/O -//O W/O +,/O and/O 342/O H/O -//O W/O -./O
Biol/O ./O
To/O characterize/O the/O expression/O of/O this/O DNA/I repair/I enzyme/I ,/O we/O have/O isolated/O the/O corresponding/O genomic/O clone/O ./O
L/O .,/O Stange/O ,/O G/O .,/O Markovich/O ,/O D/O .,/O Biber/O ,/O J/O .,/O Testar/O ,/O X/O .,/O Zorzano/O ,/O A/O .,/O Palacin/O ,/O M/O .,/O and/O Murer/O ,/O H/O ./O
The/O nucleotide/O sequence/O of/O the/O gene/O predicts/O a/O polypeptide/O of/O 215/O amino/O acids/O (/O 25/O ./O 2/O kDa/O )/O with/O two/O putative/O membrane/O -/O spanning/O domains/O ./O
SAECG/O ,/O echocardiography/O and/O thallium/O -/O 201/O imaging/O were/O performed/O before/O and/O 1/O month/O after/O attempted/O angioplasty/O ./O
They/O were/O called/O PACE4/I and/O PC4/I ./O
265/O ,/O 1102/O -/O 1110/O )./O
Both/O fusion/O proteins/O form/O stable/O specific/O complexes/O with/O a/O short/O DNA/O duplex/O harboring/O the/O CTGT/O (/O at/O )/O 4ACAG/O consensus/O sequence/O of/O the/O LexA/I repressor/I ./O
Ten/O selenocysteine/O residues/O (/O deduced/O )/O are/O present/O ./O
CONCLUSIONS/O :/O Free/O protein/I S/I deficiency/O is/O common/O among/O hospitalized/O patients/O ,/O even/O in/O the/O absence/O of/O a/O recognized/O predisposing/O condition/O ./O
During/O the/O past/O decade/O ,/O different/O types/O of/O endogenous/O retroviral/O sequences/O have/O been/O defined/O in/O the/O human/O genome/O usually/O by/O low/O stringency/O hybridization/O employing/O DNA/O probes/O of/O evolutionary/O conserved/O animal/O retrovirus/O genes/O ./O
As/O the/O components/O of/O these/O complexes/O ,/O at/O least/O five/O TRBPs/I (/O p30/I ,/O p37/I ,/O p46/I ,/O p50/I ,/O and/O p56/I )/O showing/O specific/O binding/O to/O the/O TAR/O RNA/O were/O detected/O in/O the/O uv/O cross/O -/O linking/O assay/O ./O
The/O obvious/O functional/O necessity/O for/O editing/O in/O kinetoplastid/O mitochondria/O is/O the/O formation/O of/O translatable/O mRNAs/O ./O
The/O use/O of/O this/O model/O for/O investigating/O pathophysiologically/O significant/O issues/O in/O denervating/O diseases/O is/O illustrated/O with/O five/O different/O sets/O of/O parameters/O ./O
An/O extensive/O inverted/O repeat/O is/O present/O 3/O '/O of/O rpeA/I ;/O inverted/O repeats/O are/O found/O downstream/O of/O all/O PE/I operons/I sequenced/O to/O date/O ,/O although/O the/O sequence/O is/O not/O conserved/O ./O
We/O describe/O a/O novel/O cytoplasmic/I tyrosine/I kinase/I ,/O termed/O BPK/I (/O B/I cell/I progenitor/I kinase/I ),/O which/O is/O expressed/O in/O all/O stages/O of/O the/O B/O lineage/O and/O in/O myeloid/O cells/O ./O
Large/O differences/O between/O the/O groups/O were/O not/O observed/O in/O HA/I -/I synthesizing/I enzyme/I activity/O ,/O but/O degradative/O enzyme/O activity/O was/O much/O higher/O in/O aspirin/O -/O induced/O asthma/O -/O related/O polyps/O than/O in/O other/O types/O of/O nasal/O polyps/O tested/O ./O
In/O the/O multivariate/O analysis/O ,/O six/O variables/O were/O independently/O correlated/O with/O survival/O :/O blood/O urea/O nitrogen/O level/O ,/O serum/I aspartate/I aminotransferase/I level/O ,/O community/O -/O acquired/O vs/O ./O hospital/O -/O acquired/O peritonitis/O ,/O age/O ,/O Child/O -/O Pugh/O score/O and/O ileus/O ./O
Localization/O of/O the/O intronless/O gene/O coding/O for/O calmodulin/I -/I like/I protein/I CLP/I to/O human/O chromosome/O 10p13/O -/O ter/O ./O
In/O wandering/O stage/O larvae/O ,/O the/O OBP/I transcript/I appeared/O to/O be/O at/O least/O 250/O -/O fold/O less/O abundant/O than/O ribosomal/O RNA/O ./O
One/O such/O mutant/O also/O affects/O the/O overlapping/O -/O 10/O hexamer/O of/O PR/O and/O results/O in/O reduced/O occupancy/O by/O both/O MerR/I and/O RNA/I polymerase/I ,/O likely/O as/O a/O result/O of/O inefficient/O transcriptional/O initiation/O of/O merR/I mRNA/I ./O
However/O ,/O L/I -/I plastin/I has/O been/O found/O in/O many/O types/O of/O malignant/O human/O cells/O of/O non/O -/O hemopoietic/O origin/O suggesting/O that/O its/O expression/O is/O induced/O accompanying/O tumorigenesis/O in/O solid/O tissues/O ./O
Finally/O ,/O we/O present/O evidence/O that/O fimbrin/I is/O a/O third/O distinct/O plastin/I isoform/I which/O is/O specifically/O expressed/O at/O high/O levels/O in/O the/O small/O intestine/O ./O
This/O promoter/O could/O direct/O the/O constitutive/O expression/O of/O the/O reporter/O beta/I -/I galactosidase/I at/O high/O frequency/O in/O transfected/O colonies/O of/O transformed/O cells/O that/O express/O L/I -/I plastin/I constitutively/O ;/O by/O contrast/O ,/O this/O promoter/O was/O virtually/O inactive/O in/O transfected/O colonies/O of/O normal/O fibroblasts/O and/O it/O exhibited/O a/O low/O frequency/O of/O constitutive/O activation/O in/O transfected/O colonies/O of/O in/O vitro/O SV40/O -/O transformed/O fibroblasts/O which/O did/O not/O exhibit/O L/I -/I plastin/I expression/O ./O
The/O half/O -/O life/O of/O the/O serum/O -/O induced/O CBP/I //O tk/I binding/O activity/O was/O estimated/O to/O be/O less/O than/O 1/O h/O .(/O ABSTRACT/O TRUNCATED/O AT/O 400/O WORDS/O )/O
The/O DNase/I I/I footprint/O extended/O 5/O '/O in/O the/O silencer/O region/O to/O include/O an/O inverted/O repeat/O of/O a/O six/O -/O nucleotide/O motif/O (/O epsilon/O -/O 267/O to/O -/O 278/O bp/O )/O which/O shares/O 5/O of/O 6/O bases/O with/O the/O GATA/I -/I 1/I consensus/I sequence/I ./O
Furthermore/O ,/O competitor/O containing/O the/O YY1/I consensus/I sequence/I competed/O for/O protein/I B/I binding/O ,/O whereas/O competitor/O containing/O a/O perfect/O yeast/I ABF/I -/I 1/I consensus/I sequence/I did/O not/O .(/O ABSTRACT/O TRUNCATED/O AT/O 400/O WORDS/O )/O
The/O gene/O includes/O three/O exons/O and/O two/O introns/O within/O 1/O ./O 6/O kilobases/O of/O DNA/O ,/O and/O the/O entire/O open/O reading/O frame/O for/O glycoprotein/I IX/I is/O included/O within/O the/O third/O exon/O ./O
Rhizobium/O meliloti/O large/O plasmid/O pRmeGR4b/O carries/O the/O nodulation/O competitiveness/O locus/O nfe/I responsible/O for/O the/O nodulation/O efficiency/O and/O competitive/O ability/O of/O strain/O GR4/O on/O alfalfa/O roots/O ./O
Further/O ,/O the/O ability/O of/O recombinant/O beta/O and/O //O or/O gamma/O chains/O to/O function/O in/O defined/O biochemical/O assays/O of/O beta/O gamma/O activity/O was/O assessed/O for/O membrane/O extracts/O and/O supernatant/O fractions/O from/O infected/O Sf9/O cells/O ./O
This/O report/O describes/O the/O identification/O of/O a/O gene/O of/O related/O function/O ,/O SMD1/I ,/O located/O immediately/O 3/O '/O to/O PRP38/I ./O
These/O data/O establish/O Smd1p/I as/O a/O required/O component/O of/O the/O cellular/O splicing/O apparatus/O and/O a/O factor/O in/O snRNA/O maturation/O and/O stability/O ./O
This/O study/O compared/O the/O gross/O and/O fine/O motor/O performance/O of/O 14/O traumatically/O brain/O -/O injured/O children/O (/O five/O to/O 15/O years/O old/O ,/O with/O loss/O of/O consciousness/O for/O at/O least/O 24/O hours/O )/O to/O 14/O normal/O children/O group/O matched/O for/O age/O and/O sex/O ./O
We/O compared/O the/O parameters/O pleural/I adenosine/I deaminase/I (/O PADA/I ,/O determined/O in/O 405/O patients/O ),/O the/O PADA/I //O serum/I ADA/I ratio/O (/O P/I //O SADA/I ;/O 276/O cases/O ),/O pleural/I lysozyme/I (/O PLYS/I ,/O 276/O cases/O ),/O the/O PLYS/I //O serum/I LYS/I ratio/O (/O P/I //O SLYS/I ;/O 276/O cases/O ),/O and/O pleural/I interferon/I gamma/I (/O IFN/I ,/O 145/O cases/O )/O regarding/O their/O ability/O to/O differentiate/O tuberculous/O pleural/O effusions/O from/O others/O ./O
These/O exons/O were/O identified/O by/O cloning/O and/O sequencing/O cDNAs/O obtained/O by/O polymerase/O chain/O reaction/O amplification/O of/O a/O fibroblast/O cDNA/O library/O ./O
Deletion/O of/O the/O apeA/I gene/I ,/O either/O with/O or/O without/O deletion/O of/O other/O proteinases/O (/O protease/I IV/I and/O aminopeptidase/I N/I ),/O did/O not/O have/O any/O effect/O on/O cell/O growth/O in/O the/O various/O media/O tested/O ./O
In/O Experiment/O 2/O scopolamine/O hydrobromide/O ,/O 0/O ./O 5/O and/O 1/O ./O 0/O mg/O //O kg/O i/O ./O p/O .,/O was/O administered/O 1/O h/O before/O each/O electrical/O stimulation/O until/O each/O rat/O showed/O the/O stage/O -/O 3/O seizure/O ./O
PNT/O ,/O ADD/O and/O BSS/O in/O the/O initial/O stage/O of/O kindling/O ,/O kindling/O rate/O for/O the/O stage/O -/O 3/O and/O -/O 5/O seizures/O ,/O seizure/O parameters/O at/O the/O first/O stage/O -/O 3/O and/O -/O 5/O were/O recorded/O and/O compared/O to/O the/O values/O of/O saline/O -/O treated/O ,/O control/O group/O ./O
CONCLUSIONS/O ./O
There/O was/O a/O positive/O correlation/O between/O pyridinium/O cross/O -/O link/O excretion/O and/O thyroid/O hormone/O concentrations/O ./O
Mutations/O truncating/O as/O many/O as/O 143/O C/O -/O terminal/O residues/O from/O the/O transcriptional/O activator/O encoded/O by/O the/O areA/I gene/I ,/O mediating/O nitrogen/O metabolite/O repression/O in/O Aspergillus/O nidulans/O ,/O do/O not/O significantly/O reduce/O the/O ability/O of/O the/O areA/I product/I to/O activate/O expression/O of/O most/O genes/O under/O areA/I control/O ./O
Naval/O personnel/O who/O exceed/O standards/O for/O %/O BF/O can/O be/O separated/O from/O active/O duty/O ./O
Weak/O promoter/O activity/O was/O observed/O for/O the/O promoter/O of/O the/O C1/I and/O C2/I ORFs/O (/O C1/I -/O C2/I gene/O )/O and/O for/O the/O promoter/O of/O the/O V1/I ORF/I ./O
The/O activity/O of/O the/O coat/I protein/I promoter/I of/O chloris/O striate/O mosaic/O virus/O is/O enhanced/O by/O its/O own/O and/O C1/I -/O C2/I gene/O products/O ./O
The/O amino/O acid/O sequence/O alignment/O of/O TC/I II/I with/O that/O of/O other/O Cbl/I binding/I proteins/I (/O rat/I intrinsic/I factor/I ,/O human/I transcobalamin/I I/I and/O porcine/I haptocorrin/I )/O revealed/O only/O 33/O %/O overall/O homology/O ./O
This/O short/O communication/O compares/O a/O novel/O fluorimetric/O microplate/O enzyme/O immunoassay/O (/O FEIA/O )/O with/O a/O commercial/O time/O -/O resolved/O fluoroimmunoassay/O for/O the/O determination/O of/O thyrotropin/I in/O dried/O blood/O spots/O ./O
The/O evaluation/O was/O performed/O using/O a/O retrospective/O study/O design/O with/O newborn/O blood/O samples/O from/O three/O screening/O centres/O ./O
A/O region/O in/O the/O C/O -/O terminus/O of/O adenovirus/I 2/I //I 5/I E1a/I protein/I is/O required/O for/O association/O with/O a/O cellular/O phosphoprotein/O and/O important/O for/O the/O negative/O modulation/O of/O T24/O -/O ras/I mediated/O transformation/O ,/O tumorigenesis/O and/O metastasis/O ./O
These/O studies/O demonstrate/O that/O both/O G/I alpha/I i/I genes/I are/O dynamically/O regulated/O in/O LLC/O -/O PK1/O cells/O by/O both/O growth/O ,/O differentiation/O ,/O and/O hormone/O signals/O ./O
Constructs/O containing/O the/O full/I -/I length/I PfCPK/I cDNA/I have/O been/O expressed/O in/O Escherichia/O coli/O at/O a/O high/O level/O to/O generate/O a/O 60/O -/O kDa/O recombinant/O protein/O ./O
When/O ligated/O to/O the/O proIL/I -/I 1/I beta/I cap/I site/I -/I proximal/I region/I (/O located/O between/O -/O 131/O to/O +/O 12/O ),/O both/O the/O proIL/I -/I 1/I beta/I and/O the/O simian/I virus/I 40/I enhancer/I elements/I functioned/O more/O efficiently/O in/O monocytes/O than/O in/O HeLa/O cells/O ,/O which/O are/O not/O normally/O competent/O for/O IL/I -/I 1/I beta/I expression/O ./O
Therefore/O ,/O PC/I -/I PLC/I is/O a/O component/O of/O a/O signal/O transduction/O pathway/O leading/O to/O transcription/O of/O c/I -/I fos/I and/O junB/I that/O collaborates/O with/O c/I -/I myc/I and/O is/O independent/O of/O PKC/I -/I delta/I and/O Ras/I activation/O ./O
In/O mitogen/O -/O stimulated/O splenocytes/O ,/O Gfi/I -/I 1/I expression/O begins/O to/O rise/O at/O 12/O h/O after/O stimulation/O and/O reaches/O very/O high/O levels/O after/O 50/O h/O ,/O suggesting/O that/O it/O may/O be/O functionally/O involved/O in/O events/O occurring/O after/O the/O interaction/O of/O IL/I -/I 2/I with/O its/O receptor/O ,/O perhaps/O during/O the/O transition/O from/O the/O G1/O to/O the/O S/O phase/O of/O the/O cell/O cycle/O ./O
We/O have/O isolated/O and/O characterized/O the/O GCD6/I and/O GCD7/I genes/I and/O shown/O that/O their/O products/O are/O required/O to/O repress/O GCN4/I translation/O under/O nonstarvation/O conditions/O ./O
The/O plateau/O MO2/O value/O was/O that/O predicted/O by/O allometric/O relation/O ./O
While/O the/O latter/O corresponded/O to/O a/O protein/O of/O 824/O amino/O acids/O ,/O an/O upstream/O open/O reading/O frame/O (/O uORF/O )/O within/O the/O 5/O '/O leader/O could/O potentially/O encode/O a/O 54/O amino/O acid/O peptide/O ./O
The/O SCH9/I protein/I kinase/I mRNA/I contains/O a/O long/O 5/O '/O leader/O with/O a/O small/O open/O reading/O frame/O ./O
In/O contrast/O to/O T/O cells/O ,/O in/O fibroblasts/O PILOT/I gene/I expression/O requires/O only/O one/O signal/O (/O PMA/O )/O and/O is/O not/O affected/O by/O CyA/O ./O
Histochemical/O localization/O of/O GUS/I revealed/O promoter/O function/O in/O leaf/O epidermis/O ,/O mesophyll/O and/O vascular/O bundles/O ,/O in/O the/O cortex/O and/O vascular/O cylinder/O of/O the/O root/O ./O
In/O order/O to/O investigate/O how/O these/O expression/O patterns/O are/O established/O ,/O we/O fused/O promoter/O regions/O of/O an/O acidic/O and/O a/O basic/O glucanase/I gene/I to/O the/O beta/I -/I glucuronidase/I (/O GUS/I )/O reporter/O gene/O and/O examined/O expression/O of/O these/O constructs/O in/O transgenic/O tobacco/O plants/O ./O
Southern/O blot/O analysis/O using/O probes/O from/O the/O 3/O '/O portions/O of/O the/O genomic/O and/O B/I ./I napus/I MA/I and/O MB/I cDNA/I clones/O showed/O that/O MA/I type/I myrosinases/I are/O encoded/O by/O approximately/O 4/O genes/O ,/O while/O MB/I type/I myrosinases/I are/O encoded/O by/O more/O than/O 10/O genes/O in/O B/O ./O napus/O ./O
Sudomoina/O ,/O A/O ./O
Zinc/O fingers/O (/O Zf/O )/O are/O a/O common/O structural/O motif/O found/O in/O many/O nucleic/O acid/O -/O binding/O proteins/O ./O
The/O deduced/O bovine/O EFIA/I #/I 1/I amino/O acid/O (/O aa/O )/O sequence/O is/O 98/O %/O identical/O to/O rat/O EFIA/I and/O 100/O %/O identical/O to/O human/O EFIA/I //O DbpB/I //O YB/I -/I 1/I family/O member/O DNA/I -/I binding/I protein/I B/I (/O DbpB/I )./O
Effect/O of/O tracheal/O insufflation/O of/O deferoxamine/O on/O acute/O ozone/O toxicity/O in/O rats/O ./O
Localization/O of/O the/O insertion/O locus/O in/O the/O yeast/O genome/O and/O complementation/O studies/O with/O the/O temperature/O -/O sensitive/O mutant/O indicate/O that/O the/O two/O mutations/O are/O allelic/O ./O
Replacement/O of/O the/O spacer/O sequence/O between/O the/O two/O ARMs/O with/O a/O shorter/O stretch/O of/O sequence/O also/O reduced/O RNA/O binding/O in/O vitro/O ./O
Type/O II/O could/O be/O divided/O further/O into/O two/O forms/O (/O IIA/O and/O IIB/O )/O that/O may/O represent/O two/O underscribed/O species/O or/O developmental/O stages/O of/O the/O same/O species/O ./O
Second/O ,/O the/O transcription/I factor/I Gal/I -/I ER/I was/O rendered/O more/O potent/O and/O less/O susceptible/O to/O cell/O type/O -/O specific/O variation/O by/O fusing/O the/O strong/O activating/O domain/O of/O the/O herpesvirus/I protein/I VP16/I onto/O its/O C/O terminus/O ./O
The/O exogenous/O fos/I gene/I was/O rapidly/O induced/O to/O maximal/O levels/O within/O 1/O -/O 2/O hr/O of/O estrogen/O addition/O ./O
Elimination/O of/O Haemophilus/O influenzae/O type/O b/O meningitis/O after/O introduction/O of/O vaccination/O
Endosonography/O accurately/O assessed/O tumor/O extension/O in/O two/O T2/O tumors/O ,/O 14/O T3/O tumors/O ,/O and/O seven/O T4/O tumors/O ./O
In/O the/O present/O study/O we/O demonstrated/O a/O unique/O mechanism/O of/O action/O of/O 8/O -/O Cl/O -/O cAMP/O in/O the/O regulation/O of/O these/O kinase/O isozymes/O in/O HL/O -/O 60/O human/O promyelocytic/O leukemia/O cells/O ./O
Analysis/O of/O cell/O cycle/O regulation/O in/O the/O budding/O yeast/O Saccharomyces/O cerevisiae/O has/O shown/O that/O a/O central/O regulatory/O protein/O kinase/O ,/O Cdc28/I ,/O undergoes/O changes/O in/O activity/O through/O the/O cell/O cycle/O by/O associating/O with/O distinct/O groups/O of/O cyclins/I that/O accumulate/O at/O different/O times/O ./O
Overlapping/O clones/O representing/O full/O -/O length/O cDNAs/O for/O MMI/I alpha/I were/O obtained/O from/O mouse/O brain/O ./O
The/O method/O involves/O preliminary/O isolation/O of/O oxiracetam/O and/O internal/O standard/O from/O plasma/O by/O solid/O -/O phase/O extraction/O prior/O to/O the/O formation/O of/O their/O n/O -/O propyl/O carbamate/O derivatives/O ./O
There/O are/O ,/O however/O ,/O several/O differences/O between/O the/O two/O new/O ars/O sequences/O ./O
Pathways/O linking/O the/O olfactory/O bulbs/O with/O the/O medial/O preoptic/O anterior/O hypothalamus/O are/O important/O for/O intermale/O aggression/O in/O mice/O ./O
Pokeweed/I mitogen/I (/O PWM/I )/O or/O anti/I -/I CD3/I significantly/O increases/O c/I -/I jun/I messenger/I RNA/I (/I mRNA/I )/I levels/O in/O T/O cells/O ./O
Following/O seizure/O induction/O ,/O MABP/O increased/O to/O 105/O mm/O Hg/O and/O brain/O pHi/O fell/O to/O 6/O ./O 79/O +/-/O 0/O ./O 03/O within/O 15/O min/O and/O remained/O at/O this/O level/O for/O 1/O h/O (/O P/O /O 1/O ,/O 000/O :/O 1/O on/O chromosome/O 3p/O in/O Centre/O d/O '/O Etude/O du/O Polymorphisme/O Humain/O pedigrees/O ./O
Three/O of/O these/O subunits/O are/O also/O homologous/O to/O the/O dimeric/O POR/I from/O a/O mesophilic/O archaeon/O ,/O Halobacterium/O halobium/O (/O 21/O %/O identity/O )./O
The/O transposon/O -/O inactivated/O gene/O ,/O designated/O pilP/I ,/O is/O 525/O bp/O long/O ,/O potentially/O encoding/O a/O 19/O ./O 1/O -/O kDa/O protein/O precursor/O that/O contains/O a/O typical/O membrane/O lipoprotein/O leader/O sequence/O ./O
Cheung/O and/O S/O ./O
Upstream/O of/O the/O dra/I gene/I an/O open/O reading/O frame/O of/O 313/O amino/O acids/O was/O identified/O ./O
Sucrose/O -/O specific/O regulation/O of/O scrB/I was/O also/O lost/O upon/O deletion/O of/O 4/O bp/O of/O a/O palindromic/O sequence/O (/O OB/O )/O covering/O positions/O +/O 6/O to/O +/O 21/O downstream/O of/O the/O scrB/I transcriptional/O start/O site/O ./O
In/O E/O ./O coli/O ,/O CheW/I mediates/O the/O physical/O coupling/O of/O the/O receptors/O to/O the/O kinase/O CheA/I ./O
The/O promoter/O of/O the/O first/O gene/O ,/O epiF/I ,/O responded/O to/O the/O activator/I protein/I EpiQ/I and/O contained/O a/O palindromic/O sequence/O similar/O to/O the/O EpiQ/I binding/I site/I of/O the/O epiA/I promoter/I ,/O which/O is/O also/O activated/O by/O EpiQ/I ./O
CXC/O chemokines/O bind/O to/O unique/O sets/O of/O selectivity/O determinants/O that/O can/O function/O independently/O and/O are/O broadly/O distributed/O on/O multiple/O domains/O of/O human/O interleukin/I -/I 8/I receptor/I B/I ./O
Oligodeoxynucleotides/O antisense/O to/O the/O predicted/O translation/O initiation/O regions/O of/O ICP4/I and/O pp38/I mRNAs/I inhibited/O proliferation/O of/O MSB1/O cells/O but/O not/O MDCC/O -/O CU91/O (/O CU91/O )/O reticuloendotheliosis/O virus/O -/O transformed/O cells/O ./O
Retroviral/O replication/O requires/O that/O a/O portion/O of/O the/O primary/O transcripts/O generated/O from/O proviral/O DNA/O be/O spliced/O to/O serve/O as/O mRNA/O for/O the/O envelope/I protein/I and/O in/O Rous/O sarcoma/O virus/O as/O src/I mRNA/I ./O
In/O this/O case/O the/O degree/O of/O promoter/O methylation/O ,/O which/O could/O extend/O beyond/O the/O T/O -/O DNA/O borders/O ,/O was/O not/O correlated/O with/O the/O reduction/O in/O steady/O -/O state/O poly/O (/O A/O )+/O mRNA/O levels/O ,/O the/O silenced/O state/O was/O transmitted/O through/O meiosis/O and/O reactivation/O lasted/O several/O generations/O ./O
Thus/O ,/O the/O consensus/O sequences/O for/O phosphatase/O regulation/O are/O 5/O '-/O GCACGTGGG/O -/O 3/O '/O and/O 5/O '-/O GCACGTTTT/O -/O 3/O '/O which/O differ/O from/O the/O binding/O sequences/O for/O the/O Cpflp/I protein/O required/O for/O transcription/O of/O the/O genes/O in/O methionine/O biosynthesis/O and/O for/O centromere/O function/O ./O
Here/O we/O report/O that/O the/O proline/O -/O rich/O region/O of/O CAP/I is/O recognized/O by/O the/O SH3/I domains/I of/O several/O proteins/O ,/O including/O the/O yeast/I actin/I -/I associated/I protein/I Abp1p/I ./O
We/O have/O identified/O and/O characterized/O a/O vitamin/O D/O response/O element/O (/O VDRE/O )/O in/O the/O promoter/O of/O c/I -/I fos/I ./O
In/O addition/O to/O protein/O binding/O at/O sequences/O known/O to/O be/O involved/O in/O the/O regulation/O of/O transcription/O ,/O genomic/O footprinting/O of/O the/O entire/O promoter/O region/O also/O showed/O that/O a/O protein/O factor/O is/O constitutively/O bound/O to/O the/O first/O intron/O of/O the/O rep3/I gene/I ./O
Differentiation/O was/O not/O observed/O after/O cellular/O expression/O of/O GTPase/I -/O deficient/O forms/O of/O alpha/I i2/I or/O alpha/I 0/I ,/O indicating/O selectivity/O for/O the/O Gq/I family/I of/O G/I proteins/I ./O
Consistent/O with/O a/O possible/O role/O in/O transcription/O ,/O Paf1p/I is/O localized/O to/O the/O nucleus/O ./O
By/O comparing/O the/O abundances/O of/O many/O yeast/O transcripts/O in/O isogenic/O wild/O -/O type/O and/O paf1/I mutant/I strains/O ,/O we/O have/O identified/O genes/O whose/O expression/O is/O affected/O by/O PAF1/I ./O
Paf1p/I may/O therefore/O be/O required/O for/O both/O positive/O and/O negative/O regulation/O of/O subsets/O of/O yeast/O genes/O ./O
Using/O a/O high/O -/O copy/O suppression/O strategy/O ,/O we/O have/O identified/O a/O yeast/O gene/O (/O UBS1/I )/O whose/O elevated/O expression/O suppresses/O the/O conditional/O cell/O cycle/O defects/O associated/O with/O cdc34/I mutations/O ./O
Molecular/O characterization/O of/O malignant/O melanoma/O of/O soft/O parts/O or/O soft/O tissue/O clear/O cell/O sarcoma/O which/O shares/O t/O (/O 12/O ;/O 22/O )/O chromosome/O translocation/O revealed/O fusion/O of/O EWS/I with/O a/O transcriptional/O factor/O gene/I ATF/I -/I 1/I ./O
Clones/O that/O expressed/O DBD/O exhibited/O a/O dominant/O negative/O phenotype/O and/O did/O not/O elicit/O antiviral/O activity/O against/O vesicular/O stomatitis/O virus/O (/O VSV/O )/O infection/O upon/O IFN/I treatment/O ./O
Abp1/I preferentially/O binds/O to/O multiple/O sites/O in/O ARS/I 3002/I and/O to/O the/O DNA/O polymer/O poly/O [/O d/O (/O A/O ./O T/O )]./O
Identification/O ,/O purification/O ,/O and/O molecular/O cloning/O of/O autonomously/I replicating/I sequence/I -/I binding/I protein/I 1/I from/I fission/I yeast/I Schizosaccharomyces/I pombe/I ./O
A/O short/O open/O reading/O frame/O (/O ORF2/O ),/O of/O unknown/O function/O ,/O is/O present/O in/O all/O FIV/O isolates/O ./O
The/O patient/O was/O homozygous/O for/O the/O underlying/O mutation/O ,/O which/O was/O found/O to/O be/O a/O G/O -->/O T/O transversion/O within/O the/O acceptor/O splice/O site/O between/O intron/O e/O and/O exon/O 6/O ,/O abolishing/O normal/O RNA/O splicing/O ./O
These/O regions/O overlap/O with/O the/O HIT/I protein/I similarity/I regions/I ./O
We/O tested/O 10/O rats/O with/O electrophysiologically/O guided/O ,/O ibotenic/O acid/O lesions/O of/O the/O PBN/O (/O PBNx/O )/O to/O determine/O whether/O they/O could/O acquire/O a/O LiCl/O -/O induced/O CTA/O to/O l/O -/O alanine/O (/O 0/O ./O 3/O M/O )/O or/O demonstrate/O a/O sodium/O appetite/O following/O furosemide/O treatment/O and/O overnight/O access/O to/O sodium/O deficient/O chow/O ./O
Liposomal/O Amphotericin/O -/O B/O failed/O in/O 6/O //O 7/O patients/O with/O culture/O -/O proven/O mycosis/O who/O died/O from/O infection/O with/O Aspergillus/O (/O n/O =/O 2/O )/O and/O Candida/O (/O n/O =/O 4/O ),/O respectively/O ./O
Mg2/O +/O and/O Mn2/O +/O compete/O for/O binding/O sites/O ,/O with/O the/O former/O having/O lower/O affinity/O ./O
Magnetic/O storm/O indicators/O could/O be/O used/O in/O medicine/O ,/O in/O geophysics/O and/O for/O special/O purposes/O ./O
Transgenic/O tobacco/O plants/O (/O ppa/I -/I 1/I )/O constitutively/O expressing/O Escherichia/I coli/I pyrophosphatase/I behind/O the/O 35S/I CaMV/I promoter/I accumulate/O high/O levels/O of/O soluble/O sugars/O in/O their/O leaves/O [/O 27/O ]./O
Human/I LAF/I -/I 4/I readily/O hybridized/O with/O genes/O in/O mouse/O and/O chicken/O ,/O thus/O showing/O that/O this/O gene/O family/O has/O been/O highly/O conserved/O during/O vertebrate/O evolution/O ./O
Hb/I levels/O remained/O adequate/O (/O Hb/I =/O 10/O ./O 68/O +/-/O 0/O ./O 77/O g/O //O dl/O )/O after/O 14/O ./O 6/O +/-/O 7/O ./O 64/O months/O ./O
CBT/O is/O discussed/O in/O comparison/O with/O the/O Wisconsin/O Card/O Sorting/O Test/O as/O a/O potential/O cognitive/O activation/O task/O for/O functional/O neuroimaging/O of/O the/O frontal/O lobes/O ./O
These/O data/O indicate/O that/O although/O 218leu/O retains/O normal/O transactivation/O activity/O on/O a/O p53/I promoter/I in/O yeast/O at/O physiological/O temperatures/O ,/O it/O is/O not/O capable/O of/O normal/O p53/I function/O in/O the/O presence/O of/O a/O 248trp/I allele/I in/O SNU/O -/O C5/O cells/O ./O
Cycles/O were/O repeated/O every/O 3/O weeks/O ./O
Neither/O class/O II/O nor/O IV/O infections/O precluded/O transplantation/O ./O
Although/O a/O great/O deal/O is/O understood/O about/O how/O bHLH/I factors/I activate/O gene/O transcription/O via/O E/O -/O box/O DNA/O consensus/O sequences/O ,/O studies/O of/O bHLH/I factor/I function/O in/O higher/O eukaryotes/O often/O have/O been/O hindered/O by/O the/O presence/O of/O multiple/O family/O members/O ./O
Mobility/O and/O supershift/O assays/O demonstrated/O that/O upstream/I stimulatory/I factor/I (/O USF/I )/O and/O Sp1/I bind/O to/O the/O former/O elements/O and/O competition/O experiments/O confirmed/O that/O CREB/I //O ATF/I and/O AP/I -/I 1/I bind/O to/O the/O CRE/O //O TRE/O element/O ./O
Upstream/O of/O -/O 37/O ,/O the/O 5/O '/O untranslated/O sequences/O of/O the/O isolates/O differ/O in/O both/O length/O and/O sequence/O ./O
In/O these/O cases/O ,/O greatly/O increased/O human/I chorionic/I gonadotropin/I (/O hCG/I )/O levels/O and/O suppressed/O TSH/I levels/O suggest/O that/O hCG/I has/O thyrotropic/O activity/O ./O
High/O fibrinogen/I levels/O could/O thus/O be/O a/O risk/O for/O perioperative/O thrombosis/O ./O
Strontium/O chloride/O Sr/O 89/O is/O costly/O ,/O but/O preliminary/O analysis/O indicates/O that/O it/O may/O reduce/O management/O expenditures/O overall/O .(/O ABSTRACT/O TRUNCATED/O AT/O 250/O WORDS/O )/O
We/O propose/O that/O epigenetic/O features/O of/O tissue/O -/O specific/O control/O and/O of/O the/O control/O of/O allelic/O expression/O are/O intricately/O linked/O ./O
This/O study/O determined/O the/O arthritogenic/O potential/O of/O silicone/O gel/O by/O either/O mixing/O it/O with/O bovine/I collagen/I II/I (/O BII/I )/O or/O by/O injecting/O silicone/O gel/O alone/O in/O DA/O rats/O ./O
SBF/I binds/O to/O the/O promoter/O prior/O to/O the/O activation/O of/O transcription/O in/O late/O G1/O ,/O suggesting/O that/O Cln/I //O Cdc28/I kinase/O regulates/O the/O ability/O of/O previously/O bound/O SBF/I to/O activate/O transcription/O ./O
However/O ,/O it/O remains/O an/O open/O question/O whether/O vertebrate/I Hox/I genes/I expressed/O under/O the/O control/O of/O Drosophila/O regulatory/O sequences/O can/O substitute/O the/O function/O of/O Drosophila/I Hox/I genes/I ./O
This/O approach/O places/O gHoxb/I -/I 1/I into/O the/O normal/O embryonic/O spatiotemporal/O context/O in/O which/O lab/O acts/O ./O
This/O 5/O '/O splice/O site/O sequence/O was/O required/O for/O enhanced/O polyadenylation/O and/O was/O recognized/O by/O both/O U1/I small/I nuclear/I ribonucleoproteins/I (/O snRNPs/O )/O and/O alternative/I splicing/I factor/I //O splicing/I factor/I 2/I (/O ASF/I //O SF2/I )./O
This/O analysis/O revealed/O that/O SAP/I 145/I ,/O together/O with/O four/O other/O SF3a/I //O SF3b/I subunits/O ,/O UV/O cross/O -/O links/O to/O pre/O -/O mRNA/O in/O a/O 20/O -/O nucleotide/O region/O upstream/O of/O the/O BPS/O ./O
We/O propose/O that/O CTS1/I and/I CTS2/I of/I Ci/I are/O members/O of/O two/O distinct/O classes/O of/O fungal/I chitinases/I ,/O an/O observation/O not/O previously/O reported/O for/O a/O single/O fungus/O ./O
Although/O the/O consumption/O of/O myoglobin/I -/O bound/O O2/O (/O MbO2/O )/O stores/O in/O seal/O muscles/O has/O been/O demonstrated/O in/O seal/O muscles/O during/O laboratory/O simulations/O of/O diving/O ,/O this/O may/O not/O be/O a/O feature/O of/O normal/O field/O diving/O in/O which/O measurements/O of/O heart/O rate/O and/O lactate/O production/O show/O marked/O differences/O from/O the/O profound/O diving/O response/O induced/O by/O forced/O immersion/O ./O
The/O human/I purH/I cDNA/I is/O 1776/O base/O pairs/O in/O length/O encoding/O for/O a/O 591/O -/O amino/O acid/O polypeptic/O (/O Mr/O =/O 64/O ,/O 425/O )./O
The/O Saccharomyces/O cerevisiae/O spindle/O pole/O body/O duplication/O gene/I MPS1/I is/O part/O of/O a/O mitotic/O checkpoint/O ./O
In/O our/O opinion/O ,/O the/O SM/O -/O CMA/O system/O is/O ,/O despite/O some/O shortcomings/O in/O its/O user/O -/O interface/O ,/O a/O useful/O and/O versatile/O instrument/O for/O examination/O of/O human/O semen/O samples/O ,/O with/O desirable/O features/O ./O
The/O purpose/O of/O the/O study/O reported/O here/O was/O to/O investigate/O whether/O differences/O in/O T1/O and/O T2/O between/O tumors/O are/O mainly/O a/O consequence/O of/O differences/O in/O the/O fractional/O volume/O of/O the/O extracellular/O compartment/O ./O
A/O mutant/I areA/I product/I truncated/O immediately/O after/O the/O last/O residue/O of/O the/O highly/O conserved/O GATA/I (/I DNA/I -/I binding/I )/I domain/I retains/O partial/O function/O ./O
Oligonucleotides/O ,/O designed/O on/O the/O basis/O of/O conserved/O flanking/O amino/O acid/O sequence/O segments/O within/O the/O catalytic/O domain/O of/O eukaryotic/I protein/I kinase/I C/I (/O PKC/I )/O proteins/O ,/O were/O used/O as/O primers/O for/O polymerase/O chain/O reactions/O to/O amplify/O a/O 427/O -/O bp/O chromosomal/O DNA/O fragment/O from/O the/O filamentous/O fungus/O Trichoderma/O reesei/O ./O
Disruption/O of/O RB/I //O E2F/I -/I 1/I interaction/O by/O single/O point/O mutations/O in/O E2F/I -/I 1/I enhances/O S/O -/O phase/O entry/O and/O apoptosis/O ./O
Apparent/O loss/O of/O differentiation/O markers/O characterizes/O advanced/O malignant/O neoplasms/O ./O
This/O region/O contains/O a/O motif/O with/O partial/O identity/O with/O the/O binding/O site/O for/O the/O ubiquitous/O transcription/O factor/O upstream/I stimulatory/I factor/I (/O USF/I ),/O which/O binds/O to/O the/O human/I insulin/I promoter/I ./O
The/O method/O has/O been/O satisfactorily/O applied/O to/O the/O determination/O of/O paracetamol/O in/O pharmaceutical/O formulations/O and/O biological/O fluids/O ./O
These/O primers/O yielded/O a/O PCR/O product/O of/O a/O characteristic/O length/O within/O most/O Xanthomonas/O species/O and/O pathovars/O tested/O ./O
The/O Clb5/I kinase/I ,/O which/O promotes/O S/O phase/O ,/O remains/O active/O during/O the/O G2/O -/O phase/O arrest/O of/O cells/O of/O the/O parental/O strain/O ,/O but/O its/O activity/O declines/O rapidly/O in/O sim/I mutants/I ./O
The/O C/O //O D/O ratio/O was/O equal/O to/O or/O over/O 0/O ./O 6/O in/O 9/O cases/O (/O 16/O eyes/O ),/O and/O the/O values/O were/O inconsistent/O between/O both/O eyes/O in/O 55/O %/O of/O the/O patients/O ./O
Rad6/I mutants/I display/O a/O remarkably/O pleiotropic/O phenotype/O ,/O implicating/O the/O protein/O in/O DNA/O damage/O -/O induced/O mutagenesis/O ,/O postreplication/O repair/O ,/O repression/O of/O retrotransposition/O ,/O and/O sporulation/O ./O
RNase/I protection/O assays/O revealed/O a/O correlation/O between/O the/O levels/O of/O dorsal/O and/O ventral/O skin/O expression/O with/O pigmentation/O //O phaeomelanin/O phenotypes/O ./O
Molecular/O cloning/O ,/O expression/O pattern/O ,/O and/O chromosomal/O localization/O of/O human/O CDKN2D/I //O INK4d/I ,/O an/O inhibitor/O of/O cyclin/I D/I -/I dependent/I kinases/I ./O
Overproduction/O of/O HrcA/I protein/I from/O a/O second/O copy/O of/O hrcA/I derived/O from/O a/O plasmid/O (/O phrcA/I +)/O in/O B/O ./O subtilis/O wild/O -/O type/O and/O delta/O hrcA/I strains/O prevented/O heat/O shock/O induction/O of/O the/O dnaK/I and/O groE/I operons/I at/O the/O level/O of/O transcription/O almost/O completely/O and/O strongly/O reduced/O the/O amounts/O of/O mRNA/O at/O a/O low/O temperature/O as/O well/O ./O
We/O report/O the/O molecular/O cloning/O and/O functional/O characterization/O of/O USF2/I isoforms/I ,/O corresponding/O to/O a/O 44/O -/O kDa/O subunit/O ,/O USF2a/I ,/O and/O a/O new/O 38/O -/O kDa/O subunit/O ,/O USF2b/I ,/O generated/O by/O differential/O splicing/O ./O
The/O preferential/O heterodimerization/O of/O USF/I subunits/I was/O reproduced/O ex/O vivo/O ,/O while/O the/O in/O vitro/O association/O of/O cotranslated/O subunits/O ,/O or/O recombinant/I USF/I proteins/I ,/O appeared/O to/O be/O random/O ./O
Activated/O PKR/I may/O exist/O as/O a/O dimer/O and/O phosphorylates/O the/O eukaryotic/I translation/I initiation/I factor/I 2/I alpha/I subunit/I (/O cIF/I -/I 2/I alpha/I )/O to/O inhibit/O polypeptide/O chain/O initiation/O ./O
GRP78/I ,/O a/O molecular/O chaperone/O expressed/O in/O the/O endoplasmic/O reticulum/O ,/O is/O a/O "/O glucose/O -/O regulated/O protein/O "/O induced/O by/O stress/O responses/O that/O deplete/O glucose/O or/O intracisternal/O calcium/O or/O otherwise/O disrupt/O glycoprotein/O trafficking/O ./O
The/O IL/I -/I 8/I receptor/I is/O a/O seven/O -/O transmembrane/O spanning/O receptor/O coupled/O to/O specific/O heterotrimeric/I G/I proteins/I including/O Gi/I and/O G16/I ./O
In/O a/O second/O series/O of/O experiments/O ,/O the/O efficacy/O of/O PDC/O //O HDC/O Ac/O was/O evaluated/O in/O both/O single/O and/O multiple/O dose/O regiments/O ./O
To/O elucidate/O the/O functional/O significance/O of/O Fyn/I in/O the/O expression/O of/O viral/O promoters/O ,/O we/O transfected/O a/O Fyn/I -/O expression/O vector/O together/O with/O a/O reporter/O plasmid/O containing/O the/O chloramphenicol/I acetyltransferase/I gene/I driven/O by/O HIV/I LTR/I into/O a/O human/O T/O cell/O line/O ,/O Jurkat/O ./O
We/O conducted/O a/O prospective/O ,/O randomized/O controlled/O trial/O of/O metoprolol/O ,/O a/O selective/O beta/O -/O blocker/O for/O prevention/O of/O gastrointestinal/O bleeding/O from/O portal/O hypertension/O in/O 29/O non/O -/O selected/O patients/O with/O liver/O disease/O and/O previous/O gastrointestinal/O bleeding/O ./O
A/O genetic/O and/O molecular/O analysis/O of/O non/O -/O inducible/O qutA/I mutants/I showed/O that/O all/O 23/O mutations/O analysed/O map/O within/O the/O N/O -/O terminal/O half/O of/O the/O encoded/O QUTA/I protein/I ./O
These/O studies/O indicate/O that/O the/O acidimetric/O test/O was/O less/O sensitive/O than/O the/O chromogenic/O cephalosporin/O substrates/O and/O that/O nitrocefin/O and/O S1/O could/O be/O used/O to/O screen/O for/O beta/I -/I lactamase/I production/O in/O these/O tested/O species/O ./O
Suppressors/O of/O defective/O silencing/O in/O yeast/O :/O effects/O on/O transcriptional/O repression/O at/O the/O HMR/I locus/I ,/O cell/O growth/O and/O telomere/O structure/O ./O
Although/O ANP/I induced/O systemic/O capillary/O filtration/O ,/O in/O the/O calf/O ,/O filtration/O was/O reduced/O with/O ANP/I ./O
Recent/O literature/O has/O suggested/O that/O beta/I -/I 2/I transferrin/I can/O also/O be/O used/O as/O a/O clinical/O marker/O for/O perilymph/O ./O
With/O current/O methodology/O beta/I -/I 2/I transferrin/I does/O not/O appear/O to/O be/O a/O reliable/O clinical/O marker/O for/O perilymph/O in/O the/O operative/O setting/O ./O
The/O hIGF/I -/I I/I gene/I has/O two/O promoters/O ,/O P1/O and/O P2/O ./O
Gel/O mobility/O shift/O assays/O indicated/O that/O at/O least/O four/O nuclear/O proteins/O with/O distinct/O biochemical/O and/O binding/O properties/O possess/O the/O ability/O to/O bind/O the/O 3/O beta/O I/O -/O A/O element/O to/O produce/O four/O DNA/O -/O protein/O complexes/O (/O R1/O to/O R4/O )./O
Sixty/O -/O five/O patients/O (/O aged/O between/O 3/O years/O 5/O months/O and/O 60/O years/O )/O suffering/O from/O medically/O resistant/O temporal/O lobe/O epilepsy/O (/O TLE/O )/O were/O operated/O on/O over/O a/O period/O of/O 33/O months/O in/O Bethel/O Epilepsy/O Center/O ./O
Significant/O correlations/O existed/O between/O FEV1/O and/O the/O corresponding/O values/O of/O Raw/O ,/O MEF50/O and/O MEF25/O ,/O although/O there/O were/O considerable/O individual/O differences/O between/O test/O results/O ./O
(/O 1989/O ),/O which/O is/O identical/O to/O the/O SSC1/I gene/I (/O Smith/O et/O al/O .,/O 1988/O )./O
This/O region/O also/O contains/O a/O gene/O specifying/O a/O Leu/I -/I tRNA/I precursor/I and/O a/O remnant/O of/O a/O tau/O element/O ./O
Occupational/O exposure/O to/O hepatitis/O B/O virus/O and/O human/O immunodeficiency/O virus/O :/O a/O comparative/O risk/O analysis/O ./O
Hybrid/O female/O mice/O (/O C57BL/O x/O CBA/O )/O were/O paired/O with/O breeder/O males/O (/O CD/O -/O 1/O )/O and/O LNG/O pellets/O were/O implanted/O on/O day/O 0/O ,/O the/O day/O on/O which/O copulation/O plugs/O were/O found/O ,/O or/O on/O day/O 2/O or/O day/O 3/O in/O the/O postcoital/O period/O ./O
This/O gene/O encodes/O a/O putative/O transcription/O factor/O with/O regions/O of/O homology/O to/O several/O other/O proteins/O including/O the/O zinc/O fingers/O and/O other/O domains/O of/O the/O Drosophila/I trithorax/I gene/I product/I ,/O and/O the/O "/O AT/O -/O hook/O "/O DNA/O -/O binding/O motif/O of/O high/I mobility/I group/I proteins/I ./O
Using/O reference/O probes/O as/O internal/O standards/O ,/O we/O show/O that/O the/O ost/I transcription/I unit/I is/O located/O within/O the/O cytogenetic/O band/O interval/O 89A1/O ,/O 2/O on/O the/O right/O arm/O of/O the/O third/O chromosome/O ,/O and/O that/O it/O exerts/O diagnostic/O segmentation/O gene/O expression/O patterns/O in/O the/O embryo/O ./O
The/O purified/O recombinant/O enzyme/O catalyzed/O specific/O phosphoryl/O transfer/O from/O ATP/O to/O UMP/O and/O CMP/O ./O
Studies/O on/O the/O life/O cycle/O of/O Haplorchis/O pumilio/O (/O Looss/O ,/O 1896/O )/O Looss/O ,/O 1899/O with/O morphological/O redescription/O of/O larval/O and/O adult/O stages/O ./O
Regressing/O microaneurysms/O in/O 5/O cases/O of/O hepatitis/O B/O virus/O related/O polyarteritis/O nodosa/O ./O
During/O the/O following/O pregnancy/O ultrasonographic/O studies/O of/O the/O male/O fetus/O in/O the/O 16th/O week/O of/O gestation/O revealed/O severe/O micrognathia/O ,/O short/O and/O wide/O thumbs/O ,/O and/O big/O toes/O ,/O and/O bowed/O tibiae/O ./O
Despite/O an/O overall/O survival/O rate/O of/O 43/O %,/O survival/O to/O discharge/O varied/O greatly/O (/O 0/O to/O 100/O %)/O among/O the/O 24/O diagnostic/O groups/O :/O tumor/O lysis/O syndrome/O and/O systemic/O lupus/O erythematosus/O (/O 3/O //O 3/O patients/O each/O ,/O 100/O %),/O hemolytic/O uremic/O syndrome/O (/O 8/O //O 9/O patients/O ,/O 89/O %)./O
One/O hundred/O units/O //O kg/O of/O recombinant/I human/I erythropoietin/I (/O rhEPO/I )/O was/O given/O subcutaneously/O 3/O times/O a/O week/O for/O 3/O weeks/O ./O
A/O 3/O -/O week/O regimen/O of/O erythropoietin/I may/O help/O prevent/O the/O donor/O '/O s/O need/O to/O receive/O allogeneic/O blood/O transfusion/O ,/O when/O the/O initial/O Hb/I levels/O were/O below/O 130/O milligrams/O ./O
In/O these/O constructs/O ,/O GUS/I expression/O was/O driven/O by/O promoter/O regions/O derived/O from/O the/O Arabidopsis/I alcohol/I dehydrogenase/I (/O Adh1/I ),/O maize/I ubiquitin/I (/O Ubi1/I ),/O rice/I actin/I (/O Act1/I )/O and/O CaMV/I 35S/I genes/I ./O
Its/O organization/O and/O regulation/O indicate/O that/O the/O S/I ./I pombe/I URA1/I gene/I product/I appears/O very/O similar/O to/O the/O S/I ./I cerevisiae/I URA2/I gene/I product/I ./O
The/O mean/O body/O mass/O index/O (/O BMI/O )/O was/O 31/O ./O 8/O +/-/O 6/O ./O 3/O kg/O //O m2/O and/O 28/O ./O 5/O +/-/O 6/O ./O 3/O kg/O //O m2/O in/O women/O and/O men/O ,/O respectively/O ./O
These/O findings/O demonstrate/O that/O haemodialysis/O patients/O with/O chronic/O hepatitis/O C/O respond/O well/O to/O interferon/I treatment/O and/O that/O a/O long/O -/O term/O response/O is/O achieved/O in/O a/O high/O proportion/O of/O patients/O ./O
Synthetic/O enantiomers/O of/O drugs/O
Polysome/O analysis/O further/O indicated/O that/O these/O germ/I cell/I -/I specific/I Sp1/I mRNAs/I are/O translated/O ,/O albeit/O with/O a/O lower/O efficiency/O than/O the/O somatic/O transcript/O ./O
In/O nondiabetics/O the/O response/O of/O tcPO2/O but/O not/O of/O LDF/O was/O influenced/O by/O the/O values/O at/O rest/O ./O
This/O study/O proposes/O an/O estimator/O for/O such/O global/O synchronizing/O effects/O upon/O unit/O -/O pair/O correlations/O based/O on/O local/O field/O potentials/O (/O LFPs/O )./O
The/O assembly/O of/O sequence/O ready/O ,/O high/O -/O resolution/O physical/O maps/O and/O construction/O of/O minimally/O overlapping/O contigs/O for/O the/O human/O as/O well/O as/O model/O genomes/O requires/O accurate/O determination/O of/O the/O extent/O of/O overlap/O between/O adjacent/O clones/O as/O well/O as/O their/O relative/O orientation/O ./O
(/O ii/O )/O opening/O of/O KATP/O attenuates/O ,/O inhibition/O of/O the/O channel/O exacerbates/O functional/O consequences/O of/O coronary/O occlusion/O ,/O and/O (/O iii/O )/O KATP/O opening/O attenuates/O reperfusion/O -/O induced/O VF/O ,/O but/O it/O triggers/O ischemia/O -/O induced/O VF/O ./O
The/O DNA/O sequences/O upstream/O of/O these/O termini/O exhibit/O homology/O to/O plant/O mitochondrial/O -/O processing/O sites/O ,/O therefore/O the/O proximal/O 5/O '/O ends/O are/O most/O probably/O generated/O by/O RNA/O processing/O ./O
Curing/O shrinkage/O and/O volumetric/O changes/O of/O resin/O -/O modified/O glass/O ionomer/O restorative/O materials/O ./O
Here/O we/O present/O genetic/O evidence/O suggesting/O that/O PP2A/I functions/O downstream/O of/O Ras1/I in/O the/O Sevenless/I receptor/I tyrosine/I kinase/I (/O RTK/I )/O signal/O transduction/O pathway/O that/O specifies/O R7/O photoreceptor/O cell/O fate/O in/O the/O developing/O Drosophila/O eye/O ./O
QBMDs/O for/O a/O 5/O %/O change/O in/O response/O (/O QBMD05/O )/O were/O 6/O -/O fold/O lower/O ,/O on/O average/O ,/O than/O the/O corresponding/O NOAEL/O ./O
Effects/O of/O repeated/O exposures/O of/O hydrogen/O sulphide/O on/O rat/O hippocampal/O EEG/O ./O
The/O gene/O encodes/O an/O ATP/I -/I binding/I cassette/I ,/O ABC/I transporter/I ./O
The/O T/O -/O box/O motif/O is/O present/O in/O a/O family/O of/O genes/O whose/O structural/O features/O and/O expression/O patterns/O support/O their/O involvement/O in/O developmental/O gene/O regulation/O ./O
Molecular/O analysis/O of/O a/O novel/O schizosaccharomyces/O pombe/O gene/O containing/O two/O RNP/O consensus/O -/O sequence/O RNA/O -/O binding/O domains/O ./O
Do/O overall/O treatment/O time/O ,/O field/O size/O ,/O and/O treatment/O energy/O influence/O local/O control/O of/O T1/O -/O T2/O squamous/O cell/O carcinomas/O of/O the/O glottic/O larynx/O ?/O PURPOSE/O :/O To/O evaluate/O treatment/O and/O patient/O related/O prognostic/O factors/O that/O may/O influence/O local/O control/O in/O the/O treatment/O of/O T1/O -/O T2/O squamous/O cell/O carcinoma/O of/O the/O glottic/O larynx/O ./O
In/O contrast/O to/O the/O signaling/O triggered/O by/O surface/O Ig/I engagement/O in/O B/O lymphocytes/O ,/O CD38/I ligation/O did/O not/O appear/O to/O induce/O tyrosine/O phosphorylation/O of/O the/O src/I -/I like/I protein/I tyrosine/I kinases/I lyn/I ,/O fyn/I ,/O and/O btk/I ,/O or/O of/O vav/I -/I and/I ras/I -/I GTPase/I -/I activating/I protein/I ,/O nor/O did/O it/O induce/O detectable/O changes/O in/O cytosolic/O CA2/O +/O concentrations/O ./O
Mutations/O in/O the/O alpha/I -/I amanitin/I conserved/O domain/O of/O the/O largest/O subunit/O of/O yeast/I RNA/I polymerase/I III/I affect/O pausing/O ,/O RNA/O cleavage/O and/O transcriptional/O transitions/O ./O
The/O evidence/O presented/O here/O suggests/O that/O the/O p40/I complex/I is/O a/O ribonucleoprotein/O complex/O containing/O L1Hs/I RNA/I (/I s/I )/I and/O that/O protein/O -/O protein/O interactions/O in/O which/O alpha/O -/O helix/O structures/O participate/O ,/O for/O example/O coiled/O -/O coils/O ,/O may/O occur/O in/O the/O complex/O ./O
Our/O data/O suggest/O that/O trans/O -/O activation/O from/O the/O prothymosin/I intron/I enhancer/I is/O a/O faithful/O reflection/O of/O the/O transforming/O properties/O of/O the/O Myc/I protein/I ./O
Pseudomembranous/O conjunctivitis/O following/O bone/O marrow/O transplantation/O :/O immunopathological/O and/O ultrastructural/O study/O of/O one/O case/O ./O
In/O view/O of/O the/O presence/O of/O SECIS/O elements/O in/O the/O open/O reading/O frames/O (/O ORFs/O )/O of/O bacterial/I selenoproteins/I ,/O we/O examine/O the/O effects/O in/O the/O type/I 1/I deiodinase/I of/O extending/O the/O ORF/O into/O the/O SECIS/O element/O ,/O and/O find/O that/O this/O dramatically/O inhibits/O SECIS/O function/O ./O
The/O 5/O '/O external/O transcribed/O spacer/O (/O ETS/O )/O region/O of/O the/O pre/O -/O rRNA/O in/O Saccharomyces/O cerevisiae/O contains/O a/O sequence/O with/O 10/O bp/O of/O perfect/O complementarity/O to/O the/O U3/I snoRNA/I ./O
These/O animals/O were/O viable/O and/O fertile/O ./O
This/O spindle/O defect/O of/O pds1/I mutants/I results/O from/O a/O temperature/O -/O sensitive/O step/O that/O occurs/O around/O the/O G1/O //O S/O boundary/O about/O the/O time/O of/O spindle/O assembly/O ./O
These/O data/O suggest/O that/O RPF/I -/I 1/I is/O likely/O to/O be/O involved/O in/O early/O steps/O in/O the/O differentiation/O of/O amacrine/O and/O ganglion/O cells/O ./O
In/O the/O point/O mutant/O we/O observed/O normal/O repair/O of/O endonuclease/I III/I site/I (/O i/O ./O e/O ./O as/O wild/O type/O ),/O but/O no/O removal/O of/O CPDs/O at/O the/O MAT/I alpha/I and/O HML/I alpha/I loci/I ./O
However/O ,/O for/O the/O evaluable/O cases/O ,/O the/O performances/O of/O the/O CD3500/O and/O the/O STKS/O were/O broadly/O similar/O and/O generally/O correlated/O well/O with/O the/O manual/O reference/O procedure/O ./O
Carboxy/O -/O terminal/O Spc110p/I truncations/O lacking/O the/O calmodulin/I binding/O site/O can/O support/O growth/O and/O are/O also/O phosphorylated/O in/O a/O cell/O cycle/O -/O specific/O manner/O ./O
Both/O EWS/I -/O FLI/I -/I 1/I and/O FLI/I -/I 1/I proteins/I function/O as/O transcription/O factors/O that/O bind/O specifically/O to/O ets/I sequences/O (/O the/O ets/I boxes/O )/O present/O in/O promoter/O elements/O ./O
In/O electromobility/O shift/O assays/O ,/O EWS/I -/O FLI/I -/I 1/I binding/O to/O the/O SRE/O is/O detectable/O in/O the/O absence/O of/O SRF/I whereas/O the/O binding/O of/O FLI/I -/I 1/I is/O not/O ,/O suggesting/O that/O the/O interaction/O with/O DNA/O is/O the/O step/O which/O limits/O ternary/O complex/O formation/O by/O FLI/I -/I 1/I ./O
Additional/O studies/O with/O new/O and/O reprocessed/O regenerated/O cellulose/O dialyzers/O comparing/O 450/O and/O 220/O mL/O //O min/O blood/O flow/O rates/O at/O 10/O minutes/O showed/O no/O change/O in/O BTG/O ./O
DNA/O methylation/O ,/O especially/O of/O either/O one/O or/O both/O of/O the/O deoxyadenosines/O at/O the/O two/O GATC/O motifs/O (/O one/O in/O the/O first/O exon/O and/O the/O other/O in/O the/O first/O intron/O of/O the/O rice/O CatA/I gene/I ),/O appeared/O to/O be/O responsible/O for/O the/O CatA/I promoter/I activity/O identified/O in/O the/O transient/O assay/O ./O
The/O viral/I LTR/I was/O used/O as/O the/O promoter/O ./O
Overlapping/O cDNA/O clones/O were/O isolated/O and/O sequenced/O ./O
In/O conclusion/O ,/O IgM/I class/O CIC/O is/O the/O predominant/O CIC/O in/O acute/O hepatitis/O A/O and/O correlated/O with/O disease/O activity/O ./O
Epitope/O mapping/O revealed/O that/O these/O three/O clones/O appear/O to/O recognize/O an/O identical/O epitope/O domain/O present/O on/O the/O C/O -/O terminal/O RNP/O motif/O of/O the/O U1A/I protein/I ./O
Variables/O evaluated/O were/O number/O of/O weekly/O anginal/O events/O ,/O data/O from/O ergometric/O exercise/O testing/O with/O simultaneous/O electrocardiographic/O registration/O ,/O semiquantitative/O evaluation/O of/O Tc/O -/O 99m/O 2/O -/O methoxy/O isobutyl/O isonitrile/O (/O MIBI/O )/O scans/O and/O rheologic/O variables/O ./O
As/O the/O length/O of/O the/O fatty/O acid/O decreased/O ,/O the/O binding/O affinity/O was/O reduced/O ;/O myristic/O acid/O (/O 14/O :/O 0/O )/O bound/O with/O a/O K/O (/O d/O )/O of/O 1409/O +/-/O 423/O nM/O ,/O but/O medium/O -/O chain/O (/O decanoic/O acid/O ,/O 10/O :/O 0/O )/O and/O short/O -/O chain/O (/O octanoic/O acid/O ,/O 8/O :/O 0/O )/O lipids/O were/O not/O bound/O at/O all/O ./O
The/O membrane/O -/O distal/O cytoplasmic/O region/O of/O human/I granulocyte/I colony/I -/I stimulating/I factor/I receptor/I is/O required/O for/O STAT3/I but/O not/O STAT1/I homodimer/I formation/O ./O
However/O ,/O whether/O or/O not/O nonsense/O codon/O recognition/O within/O TPI/I transcripts/I takes/O place/O prior/O to/O or/O after/O splicing/O remained/O unresolved/O ./O
Although/O some/O residues/O are/O found/O reactive/O toward/O dimethylsulphate/O and/O kethoxal/O in/O regions/O predicted/O to/O be/O unpaired/O by/O the/O phylogenetic/O secondary/O structure/O model/O of/O 4/I ./I 5S/I RNA/I ,/O generally/O the/O reactivity/O is/O low/O ,/O and/O some/O residues/O in/O internal/O loops/O are/O not/O reactive/O at/O all/O ./O
Ongoing/O and/O future/O investigations/O may/O better/O define/O the/O optimal/O approach/O for/O local/O control/O ,/O the/O optimal/O duration/O of/O maintenance/O chemotherapy/O ,/O and/O the/O possible/O role/O of/O biologic/O response/O modifiers/O and/O growth/O factors/O in/O further/O improving/O the/O outcome/O for/O patients/O with/O this/O disease/O ./O
SUMMARY/O OF/O REVIEW/O :/O We/O discuss/O the/O criteria/O that/O make/O such/O studies/O comparable/O ,/O drawing/O on/O the/O experiences/O of/O recent/O studies/O performed/O around/O the/O world/O ./O
Forty/O -/O five/O patients/O with/O pleural/O lesions/O identified/O on/O CT/O scans/O were/O subsequently/O examined/O by/O MR/O imaging/O at/O 0/O ./O 5/O T/O ./O
Left/O atrial/O volumes/O were/O greater/O in/O old/O compared/O with/O young/O subjects/O (/O maximal/O :/O 31/O +/-/O 10/O cm3/O //O m2/O vs/O 24/O +/-/O 8/O cm3/O //O m2/O ,/O p/O =/O 0/O ./O 02/O ;/O at/O onset/O of/O atrial/O systole/O :/O 23/O +/-/O 8/O cm3/O //O m2/O vs/O 15/O +/-/O 5/O cm3/O //O m2/O ,/O p/O =/O 0/O ./O 0002/O ;/O minimal/O :/O 13/O +/-/O 5/O cm3/O //O m2/O vs/O 9/O +/-/O 4/O cm3/O //O m2/O ,/O p/O =/O 0/O ./O 001/O )./O
RESULTS/O :/O Basal/O plasma/I IGF/I -/I I/I levels/O as/O well/O as/O body/O mass/O index/O (/O BMI/O )/O were/O lower/O in/O amenorrheic/O patients/O than/O in/O healthy/O controls/O ./O
We/O observed/O abundant/O levels/O of/O Rev/I -/O erbA/I alpha/I mRNA/O in/O dividing/O C2C12/O myoblasts/O ,/O which/O were/O suppressed/O when/O the/O cells/O differentiated/O into/O postmitotic/O multinucleated/O myotubes/O ./O
We/O then/O demonstrated/O that/O 1/O )/O GAL4/I -/O REV/I -/O erbA/I alpha/I chimeras/O that/O contain/O the/O '/O AB/O '/O region/O and/O lack/O the/O '/O E/O '/O region/O activated/O transcription/O of/O GAL4/I response/I elements/I in/O the/O presence/O of/O 8/O -/O Br/O -/O cAMP/O and/O 2/O )/O the/O ligand/O -/O binding/O domain/O (/O LBD/O )/O contains/O an/O active/O transcriptional/O silencer/O ./O
The/O alpha/O T3/O -/O 1/O cell/O line/O ,/O a/O GnRH/I -/O responsive/O gonadotroph/O cell/O line/O developed/O by/O targeted/O oncogenesis/O in/O transgenic/O mice/O ,/O was/O used/O to/O study/O regulation/O of/O the/O glycoprotein/I hormone/I alpha/I -/I subunit/I by/O activin/I ./O
Cotransfection/O with/O the/O ie1/I gene/I resulted/O in/O a/O dramatic/O increase/O in/O the/O amount/O of/O the/O two/O enzymes/O expressed/O in/O the/O transfected/O cells/O ./O
As/O expected/O ,/O glycosylation/O of/O Env/I produced/O from/O mutants/O was/O affected/O but/O ,/O irrespective/O of/O the/O glycosylation/O phenotype/O ,/O (/O i/O )/O similar/O quantities/O of/O Env/I were/O synthesized/O ,/O (/O ii/O )/O the/O immunoreactivity/O of/O V3/I was/O similar/O ,/O (/O iii/O )/O gp160/I was/O efficiently/O cleaved/O into/O gp120/I and/O gp41/I ,/O (/O vi/O )/O Env/I was/O exposed/O at/O the/O cell/O membrane/O ,/O (/O v/O )/O secreted/O gp120/I bound/O CD4/I ,/O and/O (/O vi/O )/O membrane/O gp41/I was/O able/O to/O induce/O membrane/O fusion/O with/O CD4/I +/I cells/O ./O
Effects/O of/O posteroventral/O pallidotomy/O on/O Parkinson/O '/O s/O disease/O ./O
On/O the/O trail/O of/O Dr/O ./O
However/O ,/O only/O complete/I DnaJ/I can/O cooperate/O with/O DnaK/I and/O a/O third/O protein/O ,/O GrpE/I ,/O in/O refolding/O denatured/I firefly/I luciferase/I ./O
The/O two/O different/O phosphoforms/O of/O STAT5/I have/O identical/O in/O vitro/O DNA/O binding/O specificity/O and/O reactivity/O with/O tyrosine/O phosphopeptides/O ,/O but/O differ/O in/O their/O cellular/O localization/O ./O
TNF/I Treatment/O of/O cell/O activated/O the/O p38/I MAP/I kinase/I pathway/O ,/O as/O revealed/O by/O increased/O phosphorylation/O of/O p38/I MAP/I kinase/I itself/O ,/O activation/O of/O the/O substrate/O protein/O MAPKAP/I kinase/I -/I 2/I ,/O and/O culminating/O in/O the/O phosphorylation/O of/O the/O heat/I shock/I protein/I 27/I (/O hsp27/I )./O
We/O have/O isolated/O a/O novel/O protein/O from/O Drosophila/O nuclear/O extracts/O which/O binds/O specifically/O to/O a/O site/O in/O this/O second/O region/O ./O
However/O ,/O while/O the/O sequence/O similarity/O between/O the/O membrane/O exons/O of/O avian/I mIgY/I and/O mammalian/I mIgG/I and/I IgE/I is/O striking/O ,/O the/O overall/O similarity/O with/O Xenopus/I mIgY/I is/O very/O low/O ./O
Control/O of/O transcription/O of/O the/O erbB/I -/I 2/I gene/I is/O an/O important/O determinant/O of/O receptor/O expression/O ./O
DNase/I I/I footprinting/O and/O electrophoretic/O mobility/O shift/O assays/O indicate/O that/O PBP/I binds/O to/O the/O half/O -/O site/O of/O each/O palindrome/O with/O the/O core/O recognition/O sequence/O TGGGAG/O ./O
These/O results/O demonstrate/O that/O sequences/O in/O the/O SH2/I //O SH3/I //O SH2/I region/O of/O p120/I GAP/I are/O required/O for/O full/O catalytic/O activity/O toward/O Ras/I ./O
The/O novel/O hematopoietic/I growth/I factor/I FLT3/I ligand/I (/O FL/I )/O is/O the/O cognate/O ligand/O for/O the/O FLT3/I ,/O tyrosine/I kinase/I receptor/I (/O R/I ),/O also/O referred/O to/O as/O FLK/I -/I 2/I and/O STK/I -/I 1/I ./O
In/O contrast/O to/O the/O selective/O expression/O of/O the/O receptor/O ,/O FL/I expression/O was/O detected/O in/O 90/O -/O 100/O %/O of/O the/O various/O cell/O types/O of/O leukemia/O cell/O lines/O from/O all/O hematopoietic/O cell/O lineages/O ./O
Further/O analysis/O of/O this/O domain/O by/O in/O vitro/O mutagenesis/O pointed/O to/O a/O core/O of/O hydrophobic/O and/O acidic/O residues/O as/O critical/O for/O the/O activity/O ./O
Analysis/O of/O RAR/I alpha/I mutants/I in/O transfection/O studies/O reveals/O that/O the/O DNA/O binding/O domain/O is/O sufficient/O for/O inhibition/O of/O BZLF1/I activity/O ./O
We/O measured/O serum/I hepatocyte/I growth/I factor/I (/O HGF/I )/O in/O patients/O with/O acute/O myocardial/O infarction/O ,/O angina/O pectoris/O ,/O and/O other/O heart/O diseases/O ./O
The/O neural/O mechanism/O of/O parkinsonian/O motor/O symptoms/O ,/O i/O ./O e/O .,/O rigidity/O ,/O tremor/O and/O akinesia/O ,/O which/O are/O the/O result/O of/O nigrostriatal/O dopamine/O deficiency/O ,/O is/O interpreted/O from/O long/O -/O term/O observations/O on/O the/O effect/O of/O surgical/O and/O pharmacological/O treatment/O of/O the/O disease/O in/O relation/O to/O the/O neuropathological/O findings/O within/O the/O substantia/O nigra/O zona/O compacta/O (/O SNc/O )./O
Protein/O splicing/O :/O evidence/O for/O an/O N/O -/O O/O acyl/O rearrangement/O as/O the/O initial/O step/O in/O the/O splicing/O process/O ./O
In/O agreement/O with/O these/O data/O ,/O western/O blot/O experiments/O using/O an/O antibody/O directed/O against/O the/O carboxy/O -/O terminal/O portion/O of/O the/O mouse/O c/I -/I kit/I protein/I showed/O that/O a/O polypeptide/O ,/O of/O the/O size/O predicted/O by/O the/O open/O reading/O frame/O of/O the/O spermatid/I -/I specific/I c/I -/I kit/I cDNA/I ,/O accumulates/O in/O the/O latest/O stages/O of/O spermatogenesis/O and/O in/O epididymal/O spermatozoa/O ./O
It/O is/O shown/O that/O the/O (/O G/O +/O C/O )-/O rich/O element/O of/O the/O aldolase/I C/I promoter/I directs/O transcription/O in/O neuronal/O as/O well/O as/O in/O nonneuronal/O cells/O ./O
LY290181/O appears/O to/O inhibit/O uPA/I promoter/I activation/O by/O blocking/O phorbol/O ester/O -/O stimulated/O binding/O of/O nuclear/O proteins/O to/O the/O uPA/I PEA3/I //O 12/O -/O 0/O -/O tetradecanoylphorbol/O 13/O -/O acetate/O responsive/O element/O (/O TRE/O )./O
Treatment/O of/O keratinocytes/O expressing/O a/O normal/O epidermal/I growth/I factor/I receptor/I (/O EGFR/I )/O with/O TGFalpha/I or/O epidermal/I growth/I factor/I for/O 5/O min/O induced/O PKCdelta/I tyrosine/O phosphorylation/O ./O
Only/O one/O of/O these/O bands/O was/O supershifted/O by/O antibody/O to/O p50/I ,/O whereas/O antibodies/O to/O p65/I or/O other/O NF/I -/I kappaB/I proteins/I had/O no/O effect/O ./O
We/O isolated/O a/O complementary/O DNA/O (/O cDNA/O )/O clone/O from/O an/O RL95/O -/O 2/O expression/O library/O that/O encodes/O the/O C1/I site/I -/I binding/I protein/I ./O
Biol/O ./O
In/O addition/O ,/O anti/I -/I phosphotyrosine/I antibodies/I immunoprecipitated/O 80K/I -/I H/I from/O cell/O lysates/O of/O FGF/I -/O stimulated/O but/O not/O from/O control/O fibroblasts/O ./O
The/O novel/O protein/O kinases/O ,/O c/I -/I Jun/I NH2/I -/I terminal/I kinases/I (/O JNKs/I )//O stress/I -/I activated/I protein/I kinases/I ,/O are/O also/O activated/O by/O TNF/I -/I alpha/I ,/O IL/I -/I 1/I ,/O and/O CD28/I costimulation/O ./O
Thus/O ,/O hGRbeta/I potentially/O functions/O as/O a/O dominant/O negative/O inhibitor/O of/O hGRalpha/I activity/O ./O
Gas6/I contains/O an/O NH2/O -/O terminal/O Gla/O domain/O followed/O by/O four/O epidermal/I growth/I factor/I -/I like/I repeats/I and/O tandem/O globular/O (/O G/O )/O domains/O ./O
Both/O P5CDh/I cDNA/I clones/O detect/O a/O single/O 3/O ./O 2/O -/O kb/O transcript/O on/O Northern/O blots/O of/O multiple/O human/O tissues/O ,/O indicating/O the/O long/O cDNA/O containing/O the/O 3/O '-/O untranslated/O intron/O represents/O the/O predominant/O transcript/O ./O
Polymerization/O of/O neurofilament/I L/I protein/I in/O vitro/O was/O inhibited/O by/O phosphorylation/O of/O neurofilament/I L/I protein/I by/O PKN/I ./O
The/O protein/O folds/O correctly/O with/O two/O disulfide/O bonds/O and/O a/O free/O thiol/O group/O at/O Cys25/O ./O
We/O and/O others/O have/O demonstrated/O that/O the/O c/I -/I cbl/I proto/I -/I oncogene/I product/I is/O one/O of/O the/O earliest/O targets/O of/O tyrosine/O phosphorylation/O upon/O T/I cell/I receptor/I stimulation/O ./O
A/O substantial/O fraction/O of/O Cbl/I was/O constitutively/O associated/O with/O Grb2/I and/O this/O interaction/O was/O mediated/O by/O Grb2/I SH3/I domains/O ./O
An/O AP/I -/I 1/I binding/I sequence/I is/O essential/O for/O regulation/O of/O the/O human/I alpha2/I (/I I/I )/I collagen/I (/O COL1A2/I )/O promoter/O activity/O by/O transforming/I growth/I factor/I -/I beta/I ./O
No/O significant/O differences/O existed/O between/O the/O two/O age/O groups/O in/O baseline/O characteristics/O ,/O including/O treatment/O protocol/O ,/O performance/O status/O ,/O and/O serum/I lactate/I dehydrogenase/I (/O LDH/I )/O level/O ./O
Only/O two/O patients/O (/O 0/O ./O 3/O %)/O had/O a/O CA/I 125/I response/O at/O the/O time/O of/O clinical/O progression/O ./O
The/O men/O self/O -/O selected/O a/O prescribed/O diet/O at/O home/O emphasizing/O saturated/O fat/O as/O the/O visible/O fat/O for/O 1/O week/O ./O
Conversely/O ,/O when/O VDR/I is/O overexpressed/O ,/O vitamin/O D3/O attenuates/O 9/O -/O cis/O RA/O induction/O from/O an/O RXR/I -/O responsive/O element/O ./O
These/O results/O illuminate/O a/O hitherto/O unanticipated/O function/O of/O U6/I RNA/I :/O the/O modulation/O of/O a/O phosphorylation/O -/O dephosphorylation/O cycle/O of/O C1/I hnRNP/I protein/I that/O influences/O the/O binding/O affinity/O of/O this/O protein/O for/O pre/O -/O mRNA/O ./O
Inclusion/O of/O the/O extended/O N/O terminus/O into/O the/O originally/O reported/O protein/O resulted/O in/O a/O striking/O similarity/O to/O the/O lymphoid/I factor/I Lef/I -/I 1/I ./O
Truncated/O mammalian/I Notch1/I activates/O CBF1/I //O RBPJk/I -/O repressed/O genes/O by/O a/O mechanism/O resembling/O that/O of/O Epstein/I -/I Barr/I virus/I EBNA2/I ./O
Electrophoretic/O mobility/O shift/O assays/O (/O EMSAs/O )/O using/O purified/O glucocorticoid/I receptor/I DNA/I binding/I domain/I (/O DBD/O )/O demonstrated/O that/O both/O GRE/I -/I 2/I and/I -/I 3/I motifs/I interact/O with/O DBD/O and/O oligonucleotide/O competition/O experiments/O established/O that/O these/O have/O different/O affinities/O for/O DBD/O ./O
The/O large/O subfamily/O of/O receptor/I tyrosine/I kinases/I (/O RTKs/I )/O for/O which/O EPH/I is/O the/O prototype/O have/O likely/O roles/O in/O intercellular/O communication/O during/O normal/O mammalian/O development/O ,/O but/O the/O biochemical/O signalling/O pathways/O utilised/O by/O this/O family/O are/O poorly/O characterised/O ./O
The/O 17/O -/O kDa/O protein/O is/O required/O for/O the/O systemic/O infection/O of/O plants/O ./O
We/O present/O here/O a/O detailed/O genomic/O sequencing/O analysis/O of/O the/O cytosine/O methylation/O patterns/O of/O the/O transposase/I binding/O sites/O within/O both/O Ac/I ends/O in/O the/O wx/I -/I m9/I ::/O Ac/I allele/I ,/O where/O Ac/I is/O inserted/O into/O the/O tenth/O exon/O of/O the/O Waxy/I gene/I ./O
Krox/I -/I 20/I ,/O a/O zinc/I finger/I gene/I ,/O has/O a/O highly/O conserved/O pattern/O of/O expression/O in/O r3/O and/O r5/O and/O is/O functionally/O required/O for/O their/O maintenance/O in/O mouse/O embryos/O ./O
Pituitary/O adenylate/I cyclase/I -/I activating/I polypeptide/I regulates/O prolactin/I promoter/I activity/O via/O a/O protein/I kinase/I A/I -/O mediated/O pathway/O that/O is/O independent/O of/O the/O transcriptional/O pathway/O employed/O by/O thyrotropin/I -/I releasing/I hormone/I ./O
Clones/O 33F/O and/O 34B/O encoded/O identical/O aromatase/I proteins/I of/O 503/O amino/O acids/O ,/O but/O differed/O in/O size/O due/O to/O alternative/O polyadenylation/O signal/O usage/O for/O the/O corresponding/O mRNAs/O ./O
In/O sorted/O bone/O marrow/O cells/O expression/O of/O both/O VpreB/I genes/I was/O detected/O in/O pro/O -/O B/O //O pre/O -/O BI/O and/O large/O pre/O -/O BII/O cells/O ,/O while/O the/O RNA/O steady/O state/O levels/O were/O at/O least/O 100/O -/O fold/O lower/O in/O small/O pre/O -/O BII/O and/O immature/O //O mature/O B/O cells/O ./O
We/O have/O cloned/O and/O sequenced/O a/O 3574/O -/O bp/O Bacillus/O subtilis/O (/O Bs/O )/O DNA/O fragment/O located/O between/O the/O nrdA/I and/O citB/I genes/I at/O about/O 169/O degrees/O on/O the/O chromosome/O ./O
Aeromonas/O salmonicida/O possesses/O two/O genes/O encoding/O homologs/O of/O the/O major/I outer/I membrane/I protein/I ,/O OmpA/I ./O
Expression/O of/O Msp/I was/O toxic/O to/O E/O ./O coli/O when/O the/O entire/O msp/I gene/I was/O present/O ./O
In/O agreement/O with/O previous/O in/O vitro/O data/O ,/O we/O have/O shown/O that/O UmuD/I and/O UmuD/I '/I are/O able/O to/O form/O both/O homodimers/O (/O UmuD/I -/O UmuD/I and/O UmuD/O '-/O UmuD/O ')/O and/O a/O heterodimer/O (/O UmuD/I -/O UmuD/O ')./O
Lyn/I kinase/I immunoprecipitated/O from/O lysates/O of/O irradiated/O BCP/O as/O well/O as/O a/O full/O -/O length/O glutathione/I S/I -/I transferase/I (/O GST/I )-/O Lyn/I fusion/O protein/O -/O phosphorylated/O recombinant/I human/I p34cdc2/I on/O tyrosine/O 15/O ./O
Mutations/O within/O conserved/O region/O 2/O (/O CR2/O )/O of/O E1A/I that/O inhibit/O the/O binding/O of/O E1A/I to/O the/O retinoblastoma/I gene/I product/I (/O pRb/I )/O further/O enhanced/O the/O stimulation/O of/O transcription/O from/O the/O PEPCK/I promoter/I by/O 2/O 3/O -/O fold/O compared/O with/O wild/I type/I E1A/I ./O
Using/O autoantibodies/O from/O a/O Sjogren/O '/O s/O syndrome/O patient/O ,/O we/O have/O previously/O identified/O a/O 230/O -/O kDa/O peripheral/O membrane/O protein/O associated/O with/O the/O cytosolic/O face/O of/O the/O trans/O -/O Golgi/O (/O Kooy/O ,/O J/O .,/O Toh/O ,/O B/O ./O
Apart/O from/O two/O proline/O -/O rich/O regions/O (/O amino/O acids/O 1/O -/O 117/O and/O 239/O -/O 270/O ),/O p230/I contains/O a/O very/O high/O frequency/O of/O heptad/O repeats/O ,/O characteristic/O of/O alpha/O -/O helices/O that/O form/O dimeric/O coiled/O -/O coil/O structures/O ./O p230/I also/O includes/O the/O sequence/O ESLALEELEL/O (/O amino/O acids/O 538/O -/O 546/O ),/O a/O motif/O found/O in/O the/O granin/I family/I of/O acidic/O proteins/O present/O in/O secretory/O granules/O of/O neuroendocrine/O cells/O ./O
Binding/O specificity/O and/O modulation/O of/O the/O ApoA/I -/I I/I promoter/I activity/O by/O homo/O -/O and/O heterodimers/O of/O nuclear/O receptors/O ./O
They/O were/O found/O to/O stimulate/O at/O nanomolar/O concentrations/O the/O turnover/O of/O biosynthetically/O labeled/O ceramide/O ,/O glucosylceramide/O ,/O and/O lactosylceramide/O ./O
There/O is/O growing/O evidence/O that/O mammalian/I AMP/I -/I activated/I protein/I kinase/I (/O AMPK/I )/O plays/O a/O role/O in/O protecting/O cells/O from/O stresses/O that/O cause/O ATP/O depletion/O by/O switching/O off/O ATP/O -/O consuming/O biosynthetic/O pathways/O ./O
Sterol/O -/O mediated/O suppression/O of/O cleavage/O of/O SREBP/I -/I 1/I was/O found/O to/O be/O dependent/O on/O the/O extreme/O COOH/O -/O terminal/O region/O (/O residue/O 1034/O to/O the/O COOH/O terminus/O ),/O which/O exists/O in/O two/O forms/O as/O a/O result/O of/O alternative/O splicing/O ./O
Am/O ./O
EMSA/O competition/O experiments/O showed/O that/O mutations/O within/O the/O direct/O repeats/O failed/O to/O compete/O for/O binding/O of/O the/O nuclear/O proteins/O to/O labeled/O wild/O type/O oligonucleotide/O ./O
Transcription/O from/O the/O promoter/O containing/O the/O mutated/O direct/O repeats/O was/O increased/O greatly/O ,/O consistent/O with/O the/O conclusion/O that/O these/O motifs/O functions/O in/O vivo/O to/O repress/O GPT/I gene/I expression/O ./O
However/O ,/O a/O >/O 10/O -/O fold/O increase/O in/O ERK3/I activity/O in/O each/O PKC/I beta/I transfectant/O was/O shown/O by/O immunoprecipitation/O with/O anti/I -/I ERK3/I monoclonal/I antibody/I followed/O by/O either/O immune/O complex/O kinase/O assay/O or/O by/O in/O gel/O kinase/O assay/O ./O
Sequence/O analysis/O of/O this/O 100/O -/O bp/O Col2a1/I enhancer/I revealed/O several/O sequence/O motifs/O similar/O to/O motifs/O present/O within/O the/O regulatory/O region/O of/O the/O link/I protein/I gene/I ,/O another/O cartilage/O gene/O ./O
Retinoid/O -/O dependent/O activation/O of/O the/O tissue/I transglutaminase/I promoter/I depends/O on/O both/O a/O proximal/O regulatory/O region/O containing/O sequences/O highly/O conserved/O between/O the/O human/O and/O the/O mouse/I tissue/I transglutaminase/I promoters/I and/O a/O distal/O region/O that/O includes/O a/O 30/O -/O base/O pair/O retinoid/O response/O element/O (/O mTGRRE1/O )./O mTGRRE1/O contains/O three/O hexanucleotide/O half/O -/O sites/O (/O two/O canonical/O and/O one/O non/O -/O canonical/O )/O in/O a/O DR7/I //O DR5/I motif/O that/O bind/O both/O RAR/I */O RXR/I heterodimers/O and/O RXR/I homodimers/I ./O
Significantly/O ,/O pPKR/I is/O capable/O of/O specifically/O phosphorylating/O Ser51/O in/O a/O synthetic/I eIF/I -/I 2alpha/I peptide/I ,/O a/O key/O characteristic/O of/O the/O eIF/I -/I 2alpha/I kinase/I family/I ./O
Vertebrate/I synapsins/I constitute/O a/O family/O of/O synaptic/O proteins/O that/O participate/O in/O the/O regulation/O of/O neurotransmitter/O release/O ./O
Electrophoretic/O mobility/O shift/O assays/O using/O crude/O extracts/O from/O FREJ4/O cells/O revealed/O the/O binding/O of/O a/O member/O (/O s/O )/O of/O the/O Ets/I family/I of/I transcription/I factors/I to/O the/O P4/I EBS/I ,/O as/O well/O as/O the/O interaction/O of/O two/O members/O of/O the/O Sp1/I family/I ,/O Sp1/I and/O Sp3/I ,/O with/O the/O adjacent/O GC/O box/O ./O
ZEBRA/I and/O cellular/O AP/I -/I 1/I bZip/I activators/I ,/O such/O as/O c/I -/I Fos/I ,/O have/O homologous/O DNA/O -/O binding/O domains/O ,/O and/O their/O DNA/O -/O binding/O specificities/O overlap/O ./O
This/O result/O suggested/O that/O mutant/O I299/O has/O diminished/O cap/O -/O binding/O activity/O ./O
UV/O cross/O -/O linking/O experiments/O demonstrated/O that/O HSV/O infection/O caused/O enhanced/O binding/O of/O protein/O factors/O ,/O including/O the/O 64/I -/I kDa/I component/I of/I cleavage/I stimulation/I factor/I (/O CstF/I ),/O to/O poly/O (/O A/O )/O site/O RNAs/O from/O virus/O genes/O of/O all/O temporal/O classes/O and/O that/O this/O enhanced/O binding/O required/O expression/O of/O IE63/I ./O
CM/I -/I ACO3/I is/O expressed/O in/O flowers/O and/O is/O not/O induced/O by/O any/O of/O the/O stimuli/O tested/O ./O
We/O show/O here/O that/O these/O Jun/I //O eb1/I chimeras/O are/O potent/O transactivators/O of/O AP1/I sites/I and/O that/O they/O can/O cooperate/O with/O c/I -/I Ha/I -/I Ras/I to/O induce/O foci/O ./O
In/O synchronized/O HeLa/O cells/O ,/O expression/O of/O luciferase/I activity/O was/O induced/O at/O the/O beginning/O of/O DNA/O synthesis/O and/O was/O dependent/O on/O the/O presence/O of/O an/O E2F/I -/I binding/I site/I in/O the/O H2A/I ./I 1/I promoter/I ./O
Utilizing/O transient/O transfection/O studies/O in/O HepG2/O cells/O ,/O we/O have/O shown/O that/O deletion/O of/O the/O factor/I VIII/I promoter/I sequences/I distal/O to/O nucleotide/O -/O 44/O results/O in/O a/O significant/O but/O small/O increase/O in/O promoter/O activity/O ./O
We/O constructed/O a/O yeast/O reporter/O strain/O containing/O the/O lacZ/I gene/I under/O the/O control/O of/O the/O CYC1/I promoter/I associated/O with/O three/O copies/O of/O TRE/I -/I 1/I ./O
If/O hnRNP/I K/I is/O a/O transcription/O factor/O ,/O then/O interactions/O with/O the/O RNA/I polymerase/I II/I transcription/O apparatus/O are/O predicted/O ./O
A/O developmentally/O regulated/O 4/O ./O 6/O kb/O mRNA/O is/O recognized/O on/O Northern/O blots/O of/O oocyte/O RNA/O using/O the/O X/O ./O laevis/O cDNA/O ./O
Sequence/O conservation/O is/O greatest/O for/O residues/O located/O near/O the/O active/O centers/O of/O the/O exo/I and/O pol/I domains/I of/O the/O E/I ./I coli/I DNA/I polymerase/I I/I structure/O ./O
Despite/O the/O favourable/O natural/O history/O of/O acute/O BI/O ,/O mild/O ,/O moderate/O ,/O and/O severe/O posttraumatic/O changes/O were/O shown/O to/O appear/O as/O cicatricial/O -/O adhesive/O and/O atrophic/O processes/O ,/O intracerebral/O cysts/O ,/O porencephaly/O ,/O which/O result/O in/O posttraumatic/O epilepsy/O ,/O hydrocephalus/O ,/O etc/O ./O
These/O findings/O suggest/O that/O the/O increase/O in/O V/O O2/O may/O have/O been/O a/O consequence/O of/O the/O increase/O in/O Q/O O2/O rather/O than/O a/O response/O to/O the/O procedure/O itself/O ./O
Several/O cytokines/O exhibit/O a/O high/O degree/O of/O temporal/O regulation/O as/O well/O as/O somnogenic/O potency/O (/O e/O ./O g/O .,/O interleukin/I -/I 1/I [/O IL/I -/I 1/I ],/O tumor/I necrosis/I factor/I -/I alpha/I [/O TNF/I -/I alpha/I ])./O
As/O pH/O and/O Hb/I can/O also/O affect/O mixed/O venous/O CO2/O content/O ,/O the/O effect/O on/O Q/O was/O also/O assessed/O ./O
No/O difference/O in/O elastin/I peptide/I concentration/O was/O observed/O between/O emphysematous/O patients/O and/O control/O subjects/O (/O mean/O +/-/O SD/O =/O 2/O ./O 39/O +/-/O 1/O ./O 18/O micrograms/O //O ml/O in/O patients/O versus/O 2/O ./O 55/O +/-/O 1/O ./O 34/O micrograms/O //O ml/O in/O policemen/O and/O 2/O ./O 59/O +/-/O 1/O ./O 20/O micrograms/O //O ml/O in/O coal/O miners/O )./O
Identification/O of/O this/O region/O as/O the/O E/I ./I coli/I tmk/I gene/I was/O confirmed/O by/O functional/O complementation/O of/O a/O yeast/I dTMP/I kinase/I temperature/O -/O sensitive/O mutant/O and/O by/O in/O vitro/O enzyme/O assay/O of/O the/O thymidylate/I kinase/I activity/O in/O cell/O extracts/O of/O E/O ./O coli/O by/O use/O of/O tmk/I -/O overproducing/O plasmids/O ./O
The/O structural/O gene/O for/O copper/I -/I and/I topa/I quinone/I -/I containing/I monoamine/I oxidase/I (/O maoA/I )/O and/O an/O unknown/O amine/I oxidase/I gene/I have/O been/O located/O at/O 30/O ./O 9/O min/O on/O the/O Escherichia/O coli/O chromosome/O ./O
This/O interaction/O is/O mediated/O by/O the/O SH2/I domain/I of/O Crk/I and/O can/O be/O inhibited/O with/O a/O phosphopeptide/O containing/O the/O Crk/I -/O SH2/I binding/O motif/O ./O
Consistent/O with/O ErbB/I -/I 2/I being/O a/O shared/O receptor/O subunit/O ,/O its/O tyrosine/O phosphorylation/O was/O increased/O by/O both/O heterologous/O ligands/O and/O it/O mediated/O a/O trans/O -/O inhibitory/O effect/O of/O NDF/I on/O EGF/I binding/O ./O
Identification/O of/O a/O consensus/O cyclin/I -/I dependent/I kinase/I phosphorylation/I site/I unique/O to/O the/O nuclear/O form/O of/O human/I deoxyuridine/I triphosphate/I nucleotidohydrolase/I ./O
The/O cDNA/O corresponding/O to/O the/O FPS1/I gene/I was/O isolated/O by/O functional/O complementation/O of/O a/O mutant/O yeast/O strain/O defective/O in/O FPS/I activity/O (/O Delourme/O ,/O D/O .,/O Lacroute/O ,/O F/O .,/O and/O Karst/O ,/O F/O ./O
The/O isolated/O plasmin/I fragments/O of/O VEGF/I were/O compared/O with/O respect/O to/O heparin/O binding/O ,/O interaction/O with/O soluble/O VEGF/I receptors/I ,/O and/O ability/O to/O promote/O endothelial/O cell/O mitogenesis/O ./O
VDR/I //O RXR/I bound/O well/O to/O the/O VDREs/O and/O to/O DR4/O and/O DR5/O using/O the/O electrophoretic/O mobility/O shift/O assay/O ./O
The/O members/O of/O the/O Myb/I family/I of/I transcription/I factors/I are/O defined/O by/O homology/O in/O the/O DNA/O -/O binding/O domain/O ;/O all/O bind/O the/O Myb/I -/I binding/I site/I (/O MBS/I )/O sequence/O (/O YG/O (/O A/O //O G/O )/O C/O (/O A/O //O C/O //O G/O )/O GTT/O (/O G/O //O A/O ))./O
In/O contrast/O ,/O when/O the/O isoform/O containing/O the/O C/O epsilon4/O domain/O joined/O directly/O to/O the/O M2/O exon/O (/O IgE/I grande/I )/O is/O expressed/O in/O the/O J558L/O cell/O line/O ,/O it/O is/O degraded/O intracellularly/O ,/O suggesting/O a/O cell/O line/O -/O dependent/O regulation/O of/O secretion/O ./O
Human/I cytomegalovirus/I immediate/I -/I early/I protein/I IE2/I tethers/O a/O transcriptional/O repression/O domain/O to/O p53/I ./O
The/O specificity/O of/O action/O of/O C/I //I EBP/I family/I members/I may/O be/O derived/O from/O the/O characteristics/O of/O each/O factor/O ,/O including/O the/O expression/O profiles/O ,/O the/O DNA/O binding/O affinities/O ,/O the/O cofactors/O ,/O and/O so/O on/O ,/O in/O addition/O to/O the/O DNA/O binding/O specificities/O ./O
The/O antibodies/O inhibited/O specifically/O the/O transcription/O of/O DNA/I polymerase/I alpha/I promoter/O in/O vitro/O ./O
Immunocytochemical/O analysis/O demonstrated/O the/O presence/O of/O DREF/I polypeptide/I in/O nuclei/O after/O the/O eighth/O nuclear/O division/O cycle/O ,/O suggesting/O that/O nuclear/O accumulation/O of/O DREF/I is/O important/O for/O the/O coordinate/O zygotic/O expression/O of/O DNA/O replication/O -/O related/O genes/O carrying/O DRE/O sequences/O ./O
A/O DNA/O fragment/O carrying/O 1/O ,/O 100/O nucleotides/O derived/O from/O the/O 5/O '-/O flanking/O region/O of/O the/O UGT1A1/I gene/I was/O enough/O for/O MC/O induction/O ./O
This/O result/O supports/O the/O argument/O that/O the/O beta/O '/O subunit/O plays/O an/O essential/O role/O in/O determining/O the/O progress/O of/O transcription/O elongation/O ./O
Two/O XPG/I regions/I with/O putative/O NLS/O [/O amino/O acid/O (/O AA/O )/O coordinates/O :/O NLS/O -/O B/O (/O AA/O 1057/O -/O 1074/O )/O and/O NLS/O -/O C/O (/O AA/O 1171/O -/O 1185/O )]/O were/O each/O shown/O to/O independently/O localize/O the/O beta/I -/I gal/I extensively/O (>/O 80/O %)/O to/O the/O nucleus/O of/O HeLa/O cells/O ./O
The/O lacS/I gene/I was/O cloned/O in/O an/O E/O ./O coli/O -/O Streptococcus/O shuttle/O vector/O and/O was/O expressed/O both/O in/O a/O lacS/I deletion/O derivative/O of/O S/O ./O thermophilus/O and/O in/O a/O pNZ63/O -/O cured/O strain/O ,/O L/O ./O lactis/O NZ6091/O ./O
The/O genome/O of/O all/O retroviruses/O consists/O of/O two/O identical/O RNAs/O noncovalently/O linked/O near/O their/O 5/O '/O end/O ./O
The/O extraction/O recovery/O of/O Amphotericin/O B/O from/O the/O cerebrospinal/O fluid/O is/O higher/O than/O 90/O %/O over/O the/O entire/O linear/O range/O ./O
HuEpo/I -/I R/I Ab/I inhibited/O Epo/I -/O induced/O parental/O UT/O -/O 7/O cell/O growth/O ,/O but/O not/O that/O of/O cells/O of/O clone/O 12/O ,/O suggesting/O that/O the/O muEpo/I -/I R/I is/O able/O to/O induce/O human/O UT/O -/O 7/O cell/O proliferation/O ./O
The/O frequency/O of/O integrations/O that/O led/O to/O transcription/O of/O the/O lacZ/I gene/I was/O estimated/O to/O be/O 0/O ./O 5/O %/O of/O all/O integrations/O ,/O of/O which/O 14/O %/O were/O downregulated/O on/O differentiation/O of/O 32D/O cells/O towards/O neutrophils/O ./O
The/O sequence/O and/O isolated/O cDNAs/O will/O provide/O useful/O reagents/O for/O studying/O the/O expression/O of/O Brca1/I in/O the/O mouse/O ,/O and/O for/O testing/O the/O importance/O of/O the/O evolutionarily/O conserved/O domains/O ./O
A/O study/O was/O performed/O to/O compare/O the/O ONLINE/O and/O EMIT/O II/O immunoassays/O with/O gas/O chromatographic/O //O mass/O spectrometric/O (/O GC/O //O MS/O )/O analysis/O of/O methaqualone/O metabolites/O on/O urine/O using/O samples/O obtained/O from/O a/O clinical/O study/O ./O
Interaction/O of/O the/O Fur/I repressor/I with/O a/O 150/O -/O bp/O fragment/O encompassing/O the/O pvdS/I promoter/I was/O demonstrated/O in/O vivo/O by/O the/O Fur/I titration/O assay/O and/O confirmed/O in/O vitro/O by/O gel/O retardation/O experiments/O with/O a/O partially/O purified/O Fur/I preparation/O ./O
This/O protein/O encoded/O by/O this/O cDNA/O ,/O which/O we/O have/O termed/O p150TSP/I (/O for/O TPR/O -/O containing/O ,/O SH2/I -/I binding/I phosphoprotein/I ),/O is/O located/O predominantly/O in/O the/O nucleus/O and/O is/O highly/O conserved/O in/O evolution/O ./O
Both/O mutant/O receptors/O were/O expressed/O on/O the/O cell/O surface/O and/O bound/O insulin/I normally/O ,/O but/O showed/O markedly/O impaired/O autophosphorylation/O in/O response/O to/O insulin/I ./O
EMBO/O J/O ./O
Taken/O together/O ,/O our/O results/O indicate/O that/O thrombin/I -/O stimulated/O vascular/O smooth/O muscle/O proliferation/O is/O delayed/O and/O requires/O the/O de/O novo/O expression/O of/O one/O or/O more/O autocrine/O mitogens/O ./O
Transcription/O from/O adenovirus/I E2/I -/I early/I promoter/I is/O controlled/O by/O a/O unique/O array/O of/O four/O cis/O -/O acting/O elements/O which/O include/O an/O atypical/O TBP/I site/I ,/O two/O E2F/I sites/I present/O in/O an/O inverted/O orientation/O relative/O to/O each/O other/O ,/O and/O an/O ATF/I site/I ./O
Furthermore/O ,/O we/O showed/O that/O the/O IL/I -/I 6/I //O interferon/I gamma/I (/O IFN/I gamma/I )/O response/O element/O in/O the/O IRF/I -/I 1/I promoter/I (/O IR/I //O IRF/I -/I 1/I ),/O which/O contains/O a/O Stat/I -/I binding/I site/I and/O an/O adjacent/O CRE/O -/O like/O site/O ,/O also/O makes/O IL/I -/I 6/I -/O induced/O binding/O complexes/O similar/O to/O JRE/O -/O IL6/I -/O BCs/O ./O
A/O second/O peptide/O (/O amino/O acids/O 58/O -/O 77/O )/O also/O antagonized/O p21/I -/O activity/O ,/O but/O this/O peptide/O did/O not/O affect/O the/O ability/O of/O p21/I to/O interact/O with/O cyclin/I E/I //O Cdk2/I ./O
A/O p21/I peptide/I spanning/O amino/O acids/O 139/O -/O 164/O was/O found/O to/O bind/O PCNA/I in/O a/O filter/O binding/O assay/O and/O this/O peptide/O suppressed/O recombinant/O p21/I -/O PCNA/I interaction/O ./O
Results/O were/O supported/O by/O the/O agar/O diffusion/O method/O for/O Y/O ./O enterocolitica/O ,/O whereas/O inhibition/O activity/O was/O not/O found/O for/O A/O ./O hydrophila/O ./O
OND/O 8/O mg/O tid/O days/O 2/O -/O 3/O ,/O and/O 8/O mg/O tid/O prn/O days/O 4/O -/O 5/O and/O prednisolone/O 75/O -/O 100/O mg/O qds/O days/O 2/O -/O 5/O and/O 2/O )/O MCP/O 30/O mg/O //O metylprednisolone/O 80/O mg/O i/O ./O v/O ./O before/O CT/O and/O MCP/O 20/O mg/O p/O ./O r/O ./O after/O 4/O and/O 8/O h/O respectively/O ./O
The/O dynamic/O properties/O of/O this/O protein/O fragment/O were/O measured/O and/O analyzed/O using/O both/O isotropic/O and/O anisotropic/O models/O of/O molecular/O motion/O ./O
Adduction/O of/O the/O human/I N/I -/I ras/I codon/I 61/I sequence/I with/O (-)-(/O 7S/O ,/O 8R/O ,/O 9R/O ,/O 10S/O )-/O 7/O ,/O 8/O -/O dihydroxy/O -/O 9/O ,/O 10/O -/O epoxy/O -/O 7/O ,/O 8/O ,/O 9/O ,/O 10/O -/O tetrahydrobenzo/O [/O a/O ]/O pyrene/O :/O structural/O refinement/O of/O the/O intercalated/O SRSR/O (/O 61/O ,/O 2/O )/O (-)-(/O 7S/O ,/O 8R/O ,/O 9S/O ,/O 10R/O )-/O N6/O -[/O 10/O -(/O 7/O ,/O 8/O ,/O 9/O ,/O 10/O -/O tetrahydrobenzo/O [/O a/O ]/O pyrenyl/O )]-/O 2/O '-/O deoxyadenosyl/O adduct/O from/O 1H/O NMR/O ./O
Isolation/O by/O PCR/O of/O a/O cDNA/O clone/O from/O pea/O petals/O with/O similarity/O to/O petunia/O and/O wheat/I zinc/I finger/I proteins/I ./O
This/O fragment/O can/O bind/O several/O trans/O -/O acting/O factors/O in/O vitro/O ,/O including/O GATA/I -/I 1/I and/O members/O of/O the/O Ets/I family/I ./O
Exposure/O of/O peripheral/O blood/O T/O cells/O from/O young/O subjects/O to/O PHA/I or/O cross/O -/O linked/O anti/I -/I CD3/I monoclonal/I antibodies/I stimulated/O rapid/O increases/O in/O MAPK/I and/O MEK/I enzymatic/O activity/O ./O
These/O different/O observations/O exclude/O a/O heterozygosity/O of/O the/O A/O -->/O G/O mutation/O at/O codon/O beta/O 77/O ,/O as/O well/O as/O a/O deletion/O comparable/O to/O that/O of/O Hbs/I Lepore/I or/I Kenya/I ,/O or/O a/O beta/I -/I globin/I gene/I duplication/O ,/O and/O point/O to/O a/O nontraditional/O inheritance/O of/O Hb/I Costa/I Rica/I ./O
This/O is/O the/O first/O description/O ,/O to/O our/O knowledge/O ,/O of/O regulatory/O elements/O that/O control/O expression/O of/O a/O gene/O encoding/O a/O B7/I costimulatory/I molecule/I ./O
DNA/I -/I STAT/I complexes/I were/O detected/O in/O all/O Bcr/I //O Abl/I -/O transformed/O cell/O lines/O and/O they/O were/O supershifted/O by/O antibodies/O against/O STAT1/I and/O STAT5/I ./O
When/O overexpressed/O in/O an/O appropriate/O cell/O line/O ,/O TAN/I -/I 1C/I prevented/O kappa/I B/I -/O dependent/O transactivation/O in/O transient/O reporter/O gene/O assays/O in/O a/O fashion/O similar/O to/O the/O structurally/O related/O protein/O ,/O Bcl/I -/I 3/I ./O
T/O cell/O leukemia/O -/O associated/O human/O Notch/I //O translocation/O -/O associated/O Notch/I homologue/O has/O I/I kappa/I B/I -/O like/O activity/O and/O physically/O interacts/O with/O nuclear/I factor/I -/I kappa/I B/I proteins/O in/O T/O cells/O ./O
Polyprotein/O processing/O in/O Southampton/O virus/O :/O identification/O of/O 3C/I -/I like/I protease/I cleavage/O sites/O by/O in/O vitro/O mutagenesis/O ./O
The/O humanized/I LL2/I (/O hLL2/I ),/O lacking/O light/I chain/I variable/I region/I glycosylation/O ,/O exhibited/O immunoreactivities/O that/O were/O comparable/O to/O that/O of/O chimeric/I LL2/I (/O cLL2/I ),/O which/O was/O shown/O previously/O to/O have/O antigen/O -/O binding/O properties/O similar/O to/O its/O murine/O counterpart/O ,/O suggesting/O that/O the/O VK/O -/O appended/O oligosaccharides/O found/O in/O mLL2/I are/O not/O necessary/O for/O antigen/O binding/O ./O
An/O apparent/O N/O -/O terminal/O transit/O peptide/O in/O the/O coding/O region/O and/O a/O 3/O '/O poly/O (/O A/O )/O tail/O exist/O in/O the/O cDNA/O clone/O indicated/O that/O this/O chloroplast/O protein/O as/O nuclear/O encoded/O ./O
Deletion/O analysis/O of/O rOC/I promoter/I -/O chloramphenicol/I acetyltransferase/I constructs/O demonstrates/O that/O an/O AML/I -/I 1/I -/I binding/I sequence/I within/O the/O proximal/O promoter/O (-/O 138/O to/O -/O 130/O nt/O )/O contributes/O to/O 75/O %/O of/O the/O level/O of/O osteocalcin/I gene/I expression/O ./O
Thus/O ,/O a/O critical/O question/O is/O how/O HOX/I proteins/I select/O the/O correct/O sets/O of/O target/O genes/O in/O vivo/O ./O
RAS2val19/I ,/O a/O dominant/O activated/O form/O of/O Saccharomyces/I cerevisiae/I Ras2/I ,/O stimulates/O both/O filamentous/O growth/O and/O expression/O of/O a/O transcriptional/O reporter/O FG/I (/O TyA/I )::/O lacZ/I but/O does/O not/O induce/O the/O mating/I pathway/I reporter/I FUS1/I ::/O lacZ/I ./O
Moreover/O ,/O the/O Rho/I family/I protein/I Cdc42/I ,/O a/O conserved/O morphogenetic/I G/I protein/I ,/O is/O also/O a/O potent/O regulator/O of/O filamentous/O growth/O and/O FG/I (/O TyA/I )::/O lacZ/I expression/O in/O S/O ./O cerevisiae/O ./O
Each/O immunoprecipitate/O contained/O a/O complex/O of/O N1/I (/I deltaEC/I )/I and/O CBF1/I ./O
This/O region/O includes/O verA/I ,/O a/O structural/O gene/O previously/O shown/O to/O be/O required/O for/O ST/O biosynthesis/O ,/O and/O 24/O additional/O closely/O spaced/O transcripts/O ranging/O in/O size/O from/O 0/O ./O 6/O to/O 7/O ./O 2/O kb/O that/O are/O coordinately/O induced/O only/O under/O ST/O -/O producing/O conditions/O ./O
Subcellular/O localizations/O of/O the/O wild/I -/I type/I CBFbeta/I and/O the/O CBFbeta/I -/O SMMHC/I fusion/O protein/O were/O determined/O by/O immunofluorescence/O of/O NIH/O 3T3/O cells/O that/O overexpress/O wild/O -/O type/O or/O fusion/O protein/O ./O
Menstrual/O -/O cycle/O phase/O did/O not/O significantly/O affect/O personality/O variables/O in/O either/O group/O ./O
We/O report/O the/O isolation/O of/O human/O cDNAs/O homologous/O to/O the/O Drosophila/I dishevelled/I (/O dsh/I )/O segment/O -/O polarity/O gene/O ./O
Escherichia/O coli/O BL21/O (/O DE3/O )/O plysS/O ,/O harbouring/O a/O recombinant/O plasmid/O containing/O the/O catalase/I -/O peroxidase/I gene/O ,/O produced/O a/O large/O amount/O of/O proteins/O that/O co/O -/O migrated/O on/O SDS/O //O PAGE/O with/O the/O native/O enzyme/O ./O
Ca2/O +/O decreased/O Zn2/O +/O binding/O in/O S100/I beta/I but/O it/O did/O not/O influence/O binding/O to/O MRP14/I ,/O suggesting/O that/O the/O Zn2/O +/O binding/O site/O was/O distinct/O from/O and/O independent/O of/O the/O two/O Ca2/O +/O binding/O domains/O ./O
Cdk2/I formed/O a/O complex/O with/O cyclin/I D1/I in/O this/O system/O ./O
The/O Cdk2/I -/O cyclin/I -/I D1/I complex/O did/O not/O phosphorylate/O any/O tested/O substrates/O ,/O such/O as/O H1/I histone/I ,/O pRB/I ,/O SV40/I large/I T/I antigen/I ,/O p53/I ,/O E2F/I -/I 1/I or/O a/O preparation/O of/O nuclear/O proteins/O from/O HeLa/O cells/O ;/O in/O contrast/O ,/O Cdk2/I -/O cyclin/I -/I E/I and/O Cdk2/I -/O cyclin/I -/I A/I phosphorylated/O these/O proteins/O ./O
Cyclin/I -/I dependent/I kinase/I -/I 2/I (/O Cdk2/I )/O forms/O an/O inactive/O complex/O with/O cyclin/I D1/I since/O Cdk2/I associated/O with/O cyclin/I D1/I is/O not/O phosphorylated/O by/O Cdk7/I -/O cyclin/I -/I H/I ./O
Two/O overlapping/O clones/O contained/O the/O complete/O Adh/I -/I 2/I gene/I composed/O of/O nine/O exons/O in/O a/O 12/O -/O kb/O region/O ,/O with/O the/O placement/O of/O introns/O matching/O that/O observed/O in/O other/O mammalian/I ADH/I genes/I ./O
Ligation/O of/O CD40/I rescues/O Ramos/O -/O Burkitt/O lymphoma/O B/O cells/O from/O calcium/O ionophore/O -/O and/O antigen/O receptor/O -/O triggered/O apoptosis/O by/O inhibiting/O activation/O of/O the/O cysteine/I protease/I CPP32/I //O Yama/I and/O cleavage/O of/O its/O substrate/O PARP/I ./O
Large/I T/I antigen/I was/O coimmunoprecipitated/O by/O antibodies/O to/O epitope/O -/O tagged/O TBP/I ,/O endogenous/O TBP/I ,/O hTAF/I (/I II/I )/I 100/I ,/O hTAF/I (/I II/I )/I 130/I ,/O and/O hTAF/I (/I II/I )/I 250/I ,/O under/O conditions/O where/O holo/I -/I TFIID/I would/O be/O precipitated/O ./O
Northern/O blot/O hybridization/O demonstrated/O that/O HEP/I -/O COP/I was/O expressed/O in/O a/O wide/O range/O of/O human/O adult/O and/O fetal/O tissues/O ./O
A/O human/O cytoplasmic/O signaling/O protein/O has/O been/O cloned/O that/O possesses/O the/O same/O structural/O arrangement/O of/O SH3/I -/O SH2/I -/O SH3/I domains/O as/O Grb2/I ./O
A/O direct/O role/O for/O sterol/I regulatory/I element/I binding/I protein/I in/O activation/O of/O 3/I -/I hydroxy/I -/I 3/I -/I methylglutaryl/I coenzyme/I A/I reductase/I gene/I ./O
E3/I //I 19K/I resides/O in/O the/O endoplasmic/O reticulum/O where/O it/O binds/O to/O MHC/I class/I I/I molecules/I ,/O thereby/O preventing/O their/O transport/O to/O the/O cell/O surface/O ./O
When/O the/O PHT/O and/O CSA/O groups/O were/O compared/O ,/O Hyp/O levels/O were/O significantly/O higher/O in/O the/O PHT/O -/O GO/O +/O group/O than/O in/O the/O CSA/O -/O GO/O +/O group/O ./O
Among/O the/O LE6/I deletions/O ,/O only/O one/O had/O a/O reduced/O transformation/O efficiency/O ,/O while/O seven/O transformed/O cells/O at/O least/O as/O efficiently/O as/O wild/I -/I type/I LE6/I ./O
ORF/I E8/I colinear/O with/O ORF/I E6/I ,/O which/O could/O generate/O a/O 50/O -/O amino/O -/O acid/O protein/O with/O a/O hydrophobic/O segment/O ,/O did/O not/O transform/O cells/O when/O cloned/O into/O the/O pZipNeo/O vector/O ./O
Cloning/O of/O individual/O ZI/O domains/O upstream/O of/O a/O minimal/O promoter/O demonstrated/O that/O the/O ZIA/O ,/O ZIC/O ,/O and/O ZID/O domains/O ,/O but/O not/O the/O ZIB/O domain/O ,/O are/O TPA/O responsive/O ./O
Clb2/I //O Cdc28/I kinase/O is/O not/O required/O for/O the/O repression/O of/O MCB/I -/I binding/I factor/I transcriptional/O activity/O in/O G2/O and/O M/O phase/O ./O
The/O carboxy/O terminus/O of/O Mbp1/I is/O sufficient/O for/O interaction/O with/O Swi6/I ,/O and/O the/O carboxy/O terminus/O of/O Swi6/I is/O required/O for/O interaction/O with/O Mbp1/I ./O
Multiple/O single/O -/O stranded/O cis/O elements/O are/O associated/O with/O activated/O chromatin/O of/O the/O human/I c/I -/I myc/I gene/I in/O vivo/O ./O
A/O new/O UASH/O consensus/O sequence/O derived/O from/O this/O mutational/O analysis/O closely/O matches/O a/O consensus/O Abf1/I binding/I site/I ./O
We/O have/O isolated/O and/O analyzed/O human/I CTCF/I cDNA/I clones/O and/O show/O here/O that/O the/O ubiquitously/O expressed/O 11/I -/I zinc/I -/I finger/I factor/I CTCF/I is/O an/O exceptionally/O highly/O conserved/O protein/O displaying/O 93/O %/O identity/O between/O avian/O and/O human/O amino/O acid/O sequences/O ./O
Mutational/O analysis/O of/O the/O P2/I -/I proximal/I CTCF/I binding/I site/I and/O transient/O -/O cotransfection/O experiments/O demonstrate/O that/O CTCF/I is/O a/O transcriptional/O repressor/O of/O the/O human/I c/I -/I myc/I gene/I ./O
A/O chromosome/I transmission/I fidelity/I (/O ctf/I )/O mutant/O ,/O s138/O ,/O of/O Saccharomyces/O cerevisiae/O was/O identified/O by/O its/O centromere/O (/O CEN/O )/O transcriptional/O readthrough/O phenotype/O ,/O suggesting/O perturbed/O kinetochore/O integrity/O in/O vivo/O ./O
The/O growth/O defect/O of/O a/O reg1/I reg2/I double/I mutant/I is/O alleviated/O by/O a/O loss/O -/O of/O -/O function/O mutation/O in/O the/O SNF1/I -/I encoded/I protein/I kinase/I ./O
Sp1/I binds/O two/O sites/O in/O the/O CD11c/I promoter/I in/O vivo/O specifically/O in/O myeloid/O cells/O and/O cooperates/O with/O AP1/I to/O activate/O transcription/O ./O
Expression/O of/O the/O phenylalanine/I hydroxylase/I gene/I in/O livers/O and/O kidneys/O of/O rodents/O is/O activated/O at/O birth/O and/O is/O induced/O by/O glucocorticoids/O and/O cyclic/O AMP/O in/O the/O liver/O ./O
We/O found/O that/O 120/O bp/O of/O the/O enhancer/O '/O s/O transcriptional/O core/O becomes/O DNase/I I/I hypersensitive/O early/O in/O B/O -/O cell/O development/O ./O
A/O developmentally/O modulated/O chromatin/O structure/O at/O the/O mouse/I immunoglobulin/I kappa/I 3/I '/I enhancer/I ./O
We/O report/O here/O the/O identification/O of/O a/O cDNA/O that/O encodes/O a/O new/O member/O of/O the/O GTPase/I -/I activating/I protein/I (/O GAP/I )/O family/O of/O GTPase/I regulators/O ./O
In/O this/O study/O ,/O we/O further/O investigated/O the/O regulation/O of/O the/O synthesis/O of/O the/O c/I -/I mos/I oncogene/I product/I ,/O which/O is/O necessary/O for/O the/O activation/O of/O Cdc2/I ./O
The/O heterogeneity/O of/O bovine/I IgG2/I --/I VIII/I ./O
The/O ability/O of/O BCL/I -/I 6/I to/O function/O as/O a/O transcriptional/O repressor/O may/O contribute/O to/O its/O ability/O to/O transform/O B/O lymphocytes/O in/O diffuse/O large/O cell/O lymphoma/O ./O
Positioning/O this/O uORF/O ,/O together/O with/O its/O accompanying/O Kozak/O sequences/O ,/O between/O a/O heterologous/O promoter/O from/O SV40/O and/O a/O CAT/I reporter/I gene/I resulted/O in/O marked/O inhibition/O of/O CAT/I protein/I production/O without/O a/O decrease/O in/O CAT/I mRNA/I ./O
A/O secondary/O spread/O of/O an/O imported/O methicillin/O -/O resistant/O Staphylococcus/O aureus/O strain/O (/O MRSA/O )/O to/O two/O other/O patients/O occurred/O within/O a/O Danish/O surgical/O ward/O in/O spite/O of/O isolation/O of/O a/O multitraumatized/O index/O -/O patient/O immediately/O after/O arrival/O from/O a/O hospital/O in/O the/O Mediterranean/O area/O ./O
Mesial/O temporal/O sclerosis/O was/O characterized/O by/O severe/O neuronal/O loss/O accompanied/O by/O gliosis/O occurring/O in/O the/O CA1/O //O prosubiculum/O (/O 27/O patients/O ,/O 100/O %),/O focally/O in/O the/O dentate/O gyrus/O (/O 12/O patients/O ,/O 44/O %),/O and/O in/O the/O CA4/O region/O (/O 11/O patients/O ,/O 41/O %)./O
Mesial/O temporal/O sclerosis/O ./O
More/O specific/O adverse/O events/O ,/O also/O frequently/O considered/O as/O dose/O -/O limiting/O toxicities/O ,/O include/O hypotension/O with/O IL/I -/I 1/I ,/O severe/O headache/O or/O skin/O rash/O with/O IL/I -/I 3/I ,/O and/O nasal/O congestion/O and/O gastroduodenal/O lesions/O with/O IL/I -/I 4/I ./O
Therefore/O ,/O magnetic/O resonance/O imaging/O was/O used/O to/O determine/O liver/O volume/O in/O pediatric/O and/O adolescent/O patients/O ,/O in/O whom/O systemic/O clearance/O of/O three/O model/O substrates/O [/O lorazepam/O (/O 0/O ./O 03/O mg/O //O kg/O ),/O antipyrine/O (/O 10/O mg/O //O kg/O ),/O and/O indocyanine/O green/O (/O ICG/O ;/O 0/O ./O 5/O mg/O //O kg/O )]/O was/O also/O determined/O ./O
A/O mutational/O analysis/O has/O resolved/O a/O region/O of/O seven/O amino/O acids/O (/O amino/O acids/O 26/O -/O 32/O )/O in/O the/O N/O -/O terminus/O of/O Bob1/I that/O are/O important/O for/O contacting/O the/O DNA/I binding/I POU/I domain/I of/O Oct/I -/I 1/I or/O Oct/I -/I 2/I ./O
Heme/I oxygenase/I 1/I is/O an/O essential/O enzyme/O in/O heme/O catabolism/O that/O cleaves/O heme/O to/O form/O biliverdin/O ,/O iron/O ,/O and/O carbon/O monoxide/O ./O
An/O inactive/O analog/O of/O wortmannin/O ,/O WM12/O ,/O did/O not/O affect/O TCR/I //O CD3/I -/O induced/O Erk2/I activation/O ,/O and/O wortmannin/O had/O no/O effect/O on/O the/O activity/O of/O Erk2/I when/O added/O directly/O to/O the/O in/O vitro/O assays/O ./O
155/O aa/O ,/O shares/O 78/O %/O identity/O with/O the/O analogous/O region/O of/O Xenopus/O laevis/O FGF3/I and/O 72/O %/O identity/O with/O the/O product/O of/O the/O more/O distantly/O related/O human/O gene/O ./O
The/O transcription/O start/O point/O of/O the/O proximal/O promoter/O aligns/O to/O that/O of/O mouse/O promoter/O P3/O and/O lies/O within/O a/O conserved/O region/O of/O sequence/O ./O
Defects/O in/O the/O Schizosaccharomyces/O pombe/O (/O Sp/O )/O cell/O cycle/O -/O controlling/O genes/O prevent/O the/O cell/O cycle/O progression/O ./O
To/O determine/O the/O signal/I recognition/I particle/I (/O SRP/I )-/O SRP/I receptor/I (/O Srb/I )/O system/O in/O Bacillus/O subtilis/O (/O Bs/O ),/O we/O cloned/O the/O Bs/I srb/I gene/I ,/O which/O encodes/O a/O homologue/O of/O the/O mammalian/I SRP/I receptor/I alpha/I -/I subunit/I [/O Oguro/O et/O al/O .,/O DNA/O Res/O ./O
A/O novel/O gene/O designated/O cmr/I ,/O which/O mapped/O to/O 18/O ./O 8/O min/O of/O the/O Escherichia/O coli/O K/O -/O 12/O genome/O ,/O was/O shown/O to/O mediate/O resistance/O to/O chloramphenicol/O when/O it/O was/O expressed/O from/O a/O multicopy/O vector/O ./O
In/O addition/O ,/O 5/O '/O deletions/O removing/O all/O but/O 34/O bp/O upstream/O of/O the/O transcription/O start/O point/O retained/O greater/O than/O 90/O %/O promoter/O activity/O ,/O suggesting/O that/O the/O -/O 35/O hexamer/O was/O not/O essential/O for/O promoter/O activity/O ./O
The/O DNA/O sequence/O immediately/O upstream/O from/O the/O -/O 10/O hexamer/O contained/O the/O TGn/O motif/O described/O as/O an/O extended/O -/O 10/O region/O in/O prokaryotic/O promoters/O ./O
An/O apparent/O ufo/I mRNA/I overexpression/O was/O not/O found/O in/O any/O of/O the/O positive/O leukemia/O cell/O lines/O ,/O but/O was/O identified/O in/O the/O drug/O -/O resistant/O subclones/O of/O the/O cervix/O carcinoma/O cell/O line/O HeLa/O ./O
We/O conclude/O from/O these/O studies/O that/O CKII/I may/O act/O as/O a/O positive/O regulator/O of/O myogenesis/O by/O preventing/O E/I protein/I homodimers/I from/O binding/O to/O muscle/O gene/O regulatory/O elements/O ./O
The/O role/O of/O negative/O regulators/O such/O as/O NCE3/I ,/O as/O well/O as/O the/O previously/O described/O SIN5/I gene/I ,/O in/O determining/O the/O promoter/O specificity/O of/O homologous/O activators/O is/O discussed/O ./O
Transcriptional/O regulators/O utilizing/O the/O POU/I domain/I DNA/I -/I binding/I motif/I have/O been/O shown/O to/O form/O multi/O -/O protein/O complexes/O dependent/O on/O the/O POU/I domain/I itself/O and/O its/O flexible/O recognition/O of/O various/O octamer/O sequence/O elements/O ./O
We/O found/O strand/O selective/O repair/O in/O DNA/O fragments/O within/O two/O active/O genes/O ,/O DHFR/I and/O an/O unknown/O gene/O adjacent/O to/O DHFR/I ./O
MATERIALS/O AND/O METHODS/O :/O Coronal/O 3D/O GRE/O imaging/O was/O used/O to/O study/O the/O volar/O ,/O middle/O ,/O and/O dorsal/O portions/O of/O the/O SLL/O in/O 14/O patients/O with/O an/O arthroscopically/O normal/O SLL/O and/O in/O five/O cadaveric/O wrists/O that/O had/O a/O normal/O SLL/O proved/O with/O dissection/O ./O
In/O an/O effort/O to/O contribute/O to/O the/O transcript/O map/O of/O human/O chromosome/O 21/O and/O the/O understanding/O of/O the/O pathophysiology/O of/O trisomy/O 21/O ,/O we/O have/O used/O exon/O trapping/O to/O identify/O fragments/O of/O chromosome/O 21/O genes/O ./O
Reproducing/O populations/O of/O this/O aphid/O were/O first/O detected/O in/O Puerto/O Rico/O in/O April/O 1992/O ./O
The/O model/O captures/O the/O essence/O of/O predator/O -/O prey/O dynamics/O to/O provide/O reasonable/O predictions/O of/O population/O patterns/O ./O
At/O cuticular/O positions/O exhibiting/O the/O Brd/I bristle/I loss/I phenotype/I ,/O we/O have/O found/O that/O the/O progeny/O of/O the/O multiplied/O SOPs/O develop/O aberrantly/O ,/O in/O that/O neurons/O and/O thecogen/O (/O sheath/O )/O cells/O appear/O but/O not/O trichogen/O (/O shaft/O )/O and/O tormogen/O (/O socket/O )/O cells/O ./O
Transcriptional/O blockade/O was/O reversed/O by/O co/O -/O transfections/O of/O a/O wild/I -/I type/I SRF/I expression/O vector/O ,/O but/O was/O not/O rescued/O by/O the/O expression/O of/O other/O myogenic/O factors/O ,/O such/O as/O MyoD/I and/O Mef/I -/I 2C/I ./O
The/O mMIWC1/I promoter/I was/O identified/O and/O contained/O TATA/O ,/O CAAT/O ,/O GATA/O ,/O and/O AP/I -/I 2/I elements/I ;/O primer/O extension/O revealed/O mMIWC/I transcription/O initiation/O at/O 621/O bp/O upstream/O from/O the/O mMIWC1/I translational/O initiation/O site/O ./O
Human/I MN/I //I CA9/I gene/I ,/O a/O novel/O member/O of/O the/O carbonic/I anhydrase/I family/I :/O structure/O and/O exon/O to/O protein/O domain/O relationships/O ./O
The/O exon/O -/O intron/O distribution/O of/O Cdebp/I appears/O strikingly/O similar/O to/O that/O of/O the/O App/I gene/I in/O the/O regions/O encoding/O the/O conserved/O domains/O ,/O with/O a/O divergent/O structure/O in/O the/O other/O parts/O ./O
DNA/O sequence/O analysis/O reveals/O that/O the/O gene/O encodes/O a/O protein/O highly/O homologous/O to/O rat/I CRP1/I ./O
The/O gene/O was/O expressed/O as/O an/O approximately/O 1/O ./O 5/O -/O kb/O mRNA/O in/O most/O nonlymphoid/O human/O cells/O //O tissues/O including/O prostate/O ,/O lung/O ,/O liver/O ,/O and/O colon/O ./O
Both/O of/O these/O domains/O have/O striking/O sequence/O homology/O with/O human/O SIM/I and/O Drosophila/O SIM/I proteins/O ./O
Promoter/O activity/O was/O high/O in/O cell/O lines/O that/O expressed/O high/O levels/O of/O endogenous/O D3/I mRNA/I ,/O as/O indicated/O by/O Northern/O blot/O analyses/O ,/O and/O was/O significantly/O reduced/O when/O the/O promoter/O was/O truncated/O to/O -/O 122/O bp/O ./O
We/O have/O obtained/O the/O human/I EP4/I receptor/I gene/I sequence/I and/O determined/O its/O structure/O relative/O to/O EP4R/I cDNA/I synthesized/O from/O peripheral/O blood/O lymphocytes/O ./O
Some/O users/O will/O willingly/O comply/O with/O management/O measures/O ,/O other/O users/O will/O comply/O in/O response/O to/O education/O ,/O but/O there/O will/O be/O another/O group/O who/O will/O only/O respond/O to/O enforcement/O activities/O ./O
Three/O separate/O activation/O subdomains/O ,/O and/O one/O negative/O -/O acting/O region/O ,/O which/O function/O in/O yeast/O were/O located/O in/O the/O carboxyl/O -/O terminal/O region/O of/O NIT4/I ./O
The/O front/O (/O F/O )/O interaction/O occurs/O ahead/O of/O the/O growing/O end/O of/O RNA/O ./O
Collectively/O ,/O these/O data/O indicate/O that/O HIP/I is/O a/O membrane/O -/O associated/O HP/I -/I binding/I protein/I expressed/O on/O the/O surface/O of/O normal/O human/O uterine/O epithelia/O and/O uterine/O epithelial/O cell/O lines/O ./O
The/O corresponding/O gene/O was/O identified/O in/O the/O GenBankTM/O data/O base/O by/O sequence/O alignment/O and/O termed/O RPS30A/I ./O
The/O location/O of/O multiple/O GRK2/I and/O GRK5/I phosphoacceptor/I sites/I at/O the/O extreme/O carboxyl/O terminus/O of/O the/O beta2AR/I is/O highly/O reminiscent/O of/O GRK1/I -/O mediated/O phosphorylation/O of/O rhodopsin/I ./O
This/O regulation/O could/O not/O be/O appreciably/O modified/O by/O enhanced/O expression/O of/O STAT/I proteins/I ./O
Receptors/O for/O interleukin/I (/I IL/I )-/I 10/I and/O IL/I -/I 6/I -/I type/I cytokines/I use/O similar/O signaling/O mechanisms/O for/O inducing/O transcription/O through/O IL/I -/I 6/I response/O elements/O ./O
Specifically/O ,/O the/O deduced/O FR/I -/I 19/I amino/I acid/I sequence/I has/O approximately89/O ,/O 77/O ,/O and/O 68/O %/O overall/O identity/O to/O chicken/I TEF/I -/I 1A/I ,/O mouse/I TEF/I -/I 1/I ,/O and/O mouse/I embryonic/I TEA/I domain/I -/I containing/I factor/I ,/O respectively/O ./O
This/O phenomenon/O did/O not/O require/O DNA/O binding/O by/O the/O "/O interfering/O "/O receptor/O but/O required/O it/O to/O be/O hormone/O -/O bound/O ,/O indicating/O that/O a/O transcriptionally/O active/O form/O of/O the/O interfering/O receptor/O is/O essential/O for/O the/O interfering/O effect/O ./O
The/O receptor/I for/I hyaluronan/I mediated/I motility/I (/I RHAMM/I )/I gene/I expression/O is/O markedly/O elevated/O in/O fibrosarcomas/O exposed/O to/O transforming/I growth/I factor/I -/I beta1/I (/O TGF/I -/I beta1/I )./O
Oncogenic/I Raf/I -/I 1/I activates/O p70/I S6/I kinase/I via/O a/O mitogen/I -/I activated/I protein/I kinase/I -/O independent/O pathway/O ./O
Hydropathy/O analysis/O of/O KCC1/I indicates/O structural/O homology/O to/O NKCC/I ,/O including/O 12/O transmembrane/O domains/O ,/O a/O large/O extracellular/O loop/O with/O potential/O N/O -/O linked/O glycosylation/O sites/O ,/O and/O cytoplasmic/O N/O -/O and/O C/O -/O terminal/O regions/O ./O
A/O cis/O -/O acting/O DNA/O element/O located/O between/O TATA/O box/O and/O transcription/O initiation/O site/O is/O critical/O in/O response/O to/O regulatory/O sequences/O in/O human/O angiotensinogen/I gene/I ./O
This/O protein/O with/O a/O hydrophobic/O amino/O terminus/O appears/O to/O be/O a/O secreted/O protein/O ./O
The/O promoter/O of/O the/O rat/I PGS/I -/I 2/I gene/I contains/O a/O CAAT/I enhancer/I -/I binding/I protein/I consensus/I site/I (/I CAAT/I box/I )/I which/O can/O confer/O hormone/O inducibility/O to/O a/O PGS/I -/I 2/I ./O CAT/I reporter/O gene/O ,/O as/O well/O as/O a/O putative/O E/O -/O box/O region/O ./O
Notably/O ,/O SRF/I has/O been/O found/O to/O be/O a/O key/O regulator/O of/O members/O of/O a/O class/O of/O cellular/O response/O genes/O termed/O immediate/I -/I early/I genes/I (/O IEGs/I ),/O many/O of/O which/O are/O believed/O to/O be/O involved/O in/O regulating/O cell/O growth/O and/O differentiation/O ./O
The/O final/O sigma54/I -/I dependent/I DmpR/I activator/I regulates/O transcription/O of/O the/O dmp/I operon/I that/O encodes/O the/O enzymes/O for/O catabolism/O of/O (/O methyl/O )/O phenols/O ./O
In/O this/O study/O ,/O we/O have/O cloned/O the/O human/I DSG3/I gene/I and/O examined/O the/O transcriptional/O regulation/O of/O its/O expression/O ./O
Clinical/O evaluation/O of/O the/O Allergan/O Humphrey/O 500/O autorefractor/O and/O the/O Nidek/O AR/O -/O 1000/O autorefractor/O ./O
None/O of/O the/O five/O proprotein/O processing/O proteases/O tested/O were/O capable/O of/O cleaving/O human/I pro/I -/I LPH/I ,/O strongly/O suggesting/O that/O they/O are/O not/O involved/O in/O the/O maturation/O of/O this/O enzyme/O ./O
These/O changes/O may/O be/O the/O result/O of/O ,/O on/O the/O one/O hand/O ,/O an/O increased/O sensitivity/O of/O the/O neuromuscular/O transmission/O and/O //O or/O decreased/O muscle/O contractility/O and/O ,/O on/O the/O other/O hand/O ,/O the/O result/O of/O a/O reduced/O plasma/O clearance/O during/O hypothermia/O ./O
SETTING/O --/O Delhi/O ,/O urban/O India/O ,/O 1985/O -/O 6/O ./O
By/O using/O interleukin/I -/I 3/I -/O dependent/O cells/O that/O ectopically/O express/O the/O three/O ErbB/I proteins/I or/O their/O combinations/O ,/O we/O found/O that/O ErbB/I -/I 3/I is/O devoid/O of/O any/O biological/O activity/O but/O both/O ErbB/I -/I 1/I and/O ErbB/I -/I 2/I can/O reconstitute/O its/O extremely/O potent/O mitogenic/O activity/O ./O
ZIOS/O was/O significantly/O more/O sensitive/O than/O all/O subsequent/O methods/O ,/O and/O Ptc/O ,/O O2/O was/O significantly/O more/O sensitive/O than/O FEV1/O ./O
Selective/O translation/O initiation/O by/O ribosome/O jumping/O in/O adenovirus/O -/O infected/O and/O heat/O -/O shocked/O cells/O ./O
Furthermore/O ,/O we/O have/O identified/O a/O 43/O -/O bp/O region/O of/O the/O 24p3/I promoter/I required/O for/O the/O Dex/O responsiveness/O ./O
These/O findings/O suggest/O that/O direct/O cDNA/O mapping/O using/O fluorescence/O in/O situ/O hybridization/O provides/O an/O accurate/O and/O rapid/O approach/O to/O the/O definition/O of/O a/O transcribed/O map/O of/O the/O human/O genome/O ./O
YAC/O and/O cosmid/O contigs/O spanning/O the/O Batten/I disease/I (/O CLN3/I )/O region/O at/O 16p12/O ./O 1/O -/O p11/O ./O 2/O ./O
Isolation/O of/O a/O near/O full/O -/O length/O cDNA/O from/O a/O human/O fetal/O brain/O cDNA/O library/O revealed/O a/O protein/I serine/I -/I threonine/I phosphatase/I with/O a/O tetratricopeptide/O motif/O ,/O almost/O identical/O to/O human/I PPP5C/I (/O PP5/I )/O and/O highly/O homologous/O to/O rat/I PPT/I ./O
Ly/I -/I 49/I is/O a/O family/I type/I II/I transmembrane/I proteins/I encoded/O by/O a/O gene/O cluster/O on/O murine/O chromosome/O 6/O ./O
The/O Dox/I -/I A2/I ORF/I driven/O by/O the/O TDH3/I promoter/I complemented/O the/O phenotype/O of/O a/O strain/O deleted/O for/O sun2/I ./O
The/O introduction/O of/O hARF4/I to/O the/O cells/O maintained/O the/O balance/O between/O cytosolic/O and/O membrane/O -/O associated/O Sec7p/I pools/O ./O
Our/O data/O demonstrate/O directly/O that/O Rpm1r/I is/O transcribed/O with/O its/O substrates/O ,/O tRNA/I met/I f/I and/O tRNAPro/I ,/O from/O a/O promoter/O located/O upstream/O of/O the/O tRNA/I met/I f/I gene/I and/O suggest/O that/O a/O portion/O also/O originates/O from/O a/O second/O promoter/O ,/O located/O between/O the/O tRNA/I met/I f/I gene/I and/O RPM1/I ./O
Furthermore/O ,/O strains/O with/O mutant/I RPM1/I genes/I also/O accumulate/O precursor/I Rpm1r/I ,/O suggesting/O that/O mutations/O in/O either/O gene/O can/O lead/O to/O similar/O biogenesis/O defects/O ./O
Vacuolar/O membrane/O vesicles/O from/O hum1/I mutants/I lack/O all/O Ca2/O +//O H/O +/O antiport/O activity/O ,/O demonstrating/O that/O Hum1p/I catalyzes/O the/O exchange/O of/O Ca2/O +/O for/O H/O +/O across/O the/O yeast/O vacuolar/O membrane/O ./O
Detailed/O mutagenesis/O of/O the/O element/O '/O s/O rare/O -/O codon/O //O AU/O -/O rich/O sequence/O boundary/O revealed/O that/O the/O destabilizing/O activity/O of/O the/O MATalpha1/I IE/I is/O observed/O when/O the/O terminal/O codon/O of/O the/O element/O '/O s/O rare/O -/O codon/O interval/O is/O translated/O ./O
FTF/I is/O also/O abundantly/O expressed/O in/O the/O pancreas/O and/O may/O exert/O differentiation/O functions/O in/O endodermal/O sublineages/O ,/O similar/O to/O SF/I -/I 1/I in/O steroidogenic/O tissues/O ./O
Merlie/O ,/O Cold/O Spring/O Harbor/O Symp/O ./O
Substantial/O evidence/O supports/O a/O critical/O role/O for/O the/O activation/O of/O the/O Raf/I -/I 1/I //O MEK/I //O mitogen/I -/I activated/I protein/I kinase/I pathway/O in/O oncogenic/O Ras/I -/O mediated/O transformation/O ./O
Stylohyoid/O chain/O ossification/O :/O choice/O of/O the/O surgical/O approach/O ./O
The/O incidence/O of/O cardiac/O death/O (/O one/O per/O group/O ),/O Q/O wave/O MI/O (/O propofol/O ,/O n/O =/O 7/O ;/O midazolam/O ,/O n/O =/O 3/O ;/O P/O =/O 0/O ./O 27/O ),/O or/O non/O Q/O wave/O MI/O (/O propofol/O ,/O n/O =/O 16/O ;/O midazolam/O ,/O n/O =/O 18/O ;/O P/O =/O 0/O ./O 81/O )/O did/O not/O differ/O between/O treatment/O groups/O ./O
63/O ./O 3/O micromol/O //O 1/O ,/O p/O /O 6/O )/O beta/O -/O D/O -/O glucoside/O ,/O have/O been/O isolated/O from/O the/O aerial/O parts/O of/O Lysionotus/O pauciflorus/O ./O
Recently/O ,/O our/O laboratory/O developed/O a/O screen/O that/O identified/O five/O multicopy/O suppressors/O that/O can/O rescue/O lethal/O strains/O of/O clathrin/I heavy/O chain/O -/O deficient/O yeast/O (/O Chc/I -/O scd1/I -/I i/I )/O to/O viability/O ./O
Reproductive/O period/O affects/O water/O intake/O in/O heat/O -/O stressed/O dehydrated/O goats/O ./O
The/O logistic/O regression/O analysis/O of/O the/O manual/O method/O (/O percentage/O normal/O morphology/O )/O and/O IVOS/O indicated/O that/O both/O were/O predictors/O of/O fertilization/O ./O
METHODS/O :/O Rats/O received/O continuous/O intragastric/O infusion/O of/O elemental/O diet/O or/O with/O supplementation/O of/O oatbase/O ,/O Lactobacillus/O reuteri/O R2LC/O ,/O and/O Lactobacillus/O plantarum/O DSM/O 9843/O ,/O with/O and/O without/O fermentation/O ,/O from/O the/O beginning/O of/O the/O study/O ./O
However/O ,/O D8/I binding/O was/O observed/O by/O nuclease/O protection/O with/O lactotroph/I -/I as/I well/I as/I somatotroph/I -/I like/I cell/I nuclear/I protein/I ./O
Limited/O role/O for/O PCR/O -/O based/O diagnosis/O of/O Whipple/O '/O s/O disease/O from/O peripheral/O blood/O mononuclear/O cells/O ./O
The/O ability/O of/O A20/I to/O block/O NF/I -/I kappaB/I activation/O was/O mapped/O to/O its/O C/O -/O terminal/O zinc/O finger/O domain/O ./O
The/O Pro/O -/O 258/O -->/O Leu/O (/O P258L/O )/O mutation/O caused/O constitutive/O receptor/O signaling/O that/O was/O equivalent/O to/O about/O 45/O %/O of/O the/O maximum/O level/O observed/O in/O wild/O -/O type/O cells/O stimulated/O with/O alpha/I -/I factor/I ./O
By/O using/O a/O DNA/O sequence/O selected/O for/O its/O ability/O to/O bind/O recombinant/I BCL/I -/I 6/I in/O vitro/O ,/O we/O show/O here/O that/O BCL/I -/I 6/I is/O present/O in/O DNA/O -/O binding/O complexes/O in/O nuclear/O extracts/O from/O various/O B/O -/O cell/O lines/O ./O
The/O predictive/O value/O of/O a/O positive/O flag/O was/O 77/O ./O 7/O %./O
CONCLUSIONS/O :/O Our/O findings/O suggest/O that/O pre/O -/O treatment/O with/O coenzyme/O Q10/O may/O play/O a/O protective/O role/O during/O routine/O vascular/O procedures/O requiring/O abdominal/O aortic/O cross/O clamping/O by/O attenuating/O the/O degree/O of/O peroxidative/O damage/O ./O
Because/O chromosome/O X/O is/O frequently/O involved/O in/O structural/O alterations/O in/O neoplastic/O Syrian/O hamster/O cells/O transformed/O by/O chemical/O carcinogens/O and/O oncogenic/O viruses/O ,/O the/O localization/O of/O the/O cph/I locus/I on/O this/O chromosome/O supports/O the/O notion/O that/O the/O cph/I oncogene/I plays/O a/O role/O in/O the/O malignant/O conversion/O of/O chemically/O transformed/O hamster/O fibroblasts/O ./O
In/O a/O screen/O for/O genes/O with/O oncogenic/O potential/O expressed/O by/O the/O murine/O B6SUtA1/O myeloid/O progenitor/O cell/O line/O ,/O we/O isolated/O a/O 2/O ./O
Gap1/O (/O IP4BP/O ),/O one/O of/O a/O member/O of/O Ras/I GTPase/I -/I activating/I proteins/I ,/O has/O been/O identified/O as/O a/O specific/O inositol/I 1/I ,/I 3/I ,/I 4/I ,/I 5/I -/I tetrakisphosphate/I (/I IP4/I )-/I binding/I protein/I (/O Cullen/O ,/O P/O ./O
We/O previously/O described/O the/O purification/O of/O an/O 83/I -/I kDa/I phosphatidic/I acid/I phosphatase/I (/O PAP/I )/O from/O the/O porcine/O thymus/O membranes/O (/O Kanoh/O ,/O H/O .,/O Imai/O ,/O S/O .-/O i/O .,/O Yamada/O ,/O K/O ./O and/O Sakane/O ,/O F/O .(/O 1992/O )/O J/O ./O
The/O mechanism/O involves/O Gbetagamma/I subunit/O -/O mediated/O increases/O in/O tyrosine/O phosphorylation/O of/O the/O Shc/I adapter/I protein/I ,/O Shc/I */O Grb2/I complex/O formation/O ,/O and/O recruitment/O of/O Ras/I guanine/I nucleotide/I exchange/I factor/I activity/O ./O
A/O cDNA/O encoding/O the/O amino/O -/O terminal/O 17/O %/O of/O apoB/I (/O apoB17/I )/O was/O fused/O to/O a/O cDNA/O coding/O for/O the/O last/O 37/O amino/O acids/O of/O decay/I -/I accelerating/I factor/I (/O DAF/I ),/O which/O contains/O the/O signal/O for/O glycosylphosphatidylinositol/O anchor/O attachment/O ./O
Next/O ,/O we/O stably/O overexpressed/O wild/I -/I type/I Shc/I or/O Y317F/I mutant/I Shc/I into/O HIRc/O cells/O ./O
The/O small/I GTPase/I Rho/I is/O implicated/O in/O physiological/O functions/O associated/O with/O actin/I -/O myosin/I filaments/O such/O as/O cytokinesis/O ,/O cell/O motility/O ,/O and/O smooth/O muscle/O contraction/O ./O
Conversely/O ,/O activation/O of/O this/O signaling/O pathway/O by/O expression/O of/O a/O constitutively/O active/O MKK1/I mutant/I dramatically/O increased/O cyclin/I D1/I promoter/O activity/O and/O cyclin/I D1/I protein/I expression/O ,/O in/O a/O growth/O factor/O -/O independent/O manner/O ./O
Furthermore/O ,/O upstream/O insertion/O of/O the/O GSTP1/I silencer/I element/I failed/O to/O inhibit/O activity/O of/O a/O heterologous/O promoter/O in/O MCF7/O cells/O ./O
In/O order/O to/O delineate/O structural/O motifs/O regulating/O substrate/O affinity/O and/O recognition/O for/O the/O human/I dopamine/I transporter/I (/O DAT/I ),/O we/O assessed/O [/O 3H/O ]/O dopamine/O uptake/O kinetics/O and/O [/O 3H/O ]/O CFT/O binding/O characteristics/O of/O COS/O -/O 7/O cells/O transiently/O expressing/O mutant/I DATs/I in/O which/O the/O COOH/O terminus/O was/O truncated/O or/O substituted/O ./O
An/O expression/O library/O was/O constructed/O by/O inserting/O 5/O '/O portion/O -/O enriched/O cDNAs/O from/O phytohemagglutinin/I -/O stimulated/O peripheral/O blood/O mononuclear/O cells/O into/O upstream/O of/O signal/I sequence/I -/I deleted/I CD4/I cDNA/I in/O an/O Epstein/O -/O Barr/O virus/O shuttle/O vector/O ./O
Radiolabeled/O recombinant/I TARC/I specifically/O bound/O to/O T/O cell/O lines/O and/O peripheral/O T/O cells/O but/O not/O to/O monocytes/O or/O granulocytes/O ./O
The/O cis/O -/O acting/O elements/O that/O control/O promoter/O activity/O include/O binding/O sites/O for/O transcription/O factors/O Sp1/I and/O alphaCbf/I ,/O a/O 60/I -/I kDa/I CCAAT/I box/I -/I binding/I protein/I ./O
Therefore/O ,/O we/O have/O identified/O a/O cis/O -/O acting/O element/O ,/O the/O E1/O E/O -/O box/O ,/O located/O in/O the/O GAP/I -/I 43/I promoter/O region/O that/O modulates/O either/O positively/O or/O negatively/O the/O expression/O of/O the/O GAP/I -/I 43/I gene/I depending/O on/O which/O E/I -/I box/I -/I binding/I proteins/I occupy/O this/O site/O ./O
Collectively/O ,/O our/O findings/O demonstrate/O that/O SF/I -/I 1/I plays/O a/O key/O role/O in/O controlling/O the/O basal/O and/O cAMP/O -/O stimulated/O expression/O of/O the/O StAR/I gene/I ./O
There/O was/O a/O general/O broadening/O of/O proton/O resonances/O for/O a/O three/O -/O nucleotide/O segment/O centered/O about/O the/O lesion/O site/O which/O resulted/O in/O a/O tentative/O assignment/O for/O the/O sugar/O protons/O of/O the/O C7/O residue/O in/O the/O spectrum/O of/O the/O adduct/O duplex/O ./O
Using/O one/O of/O the/O six/O fragments/O (/O CPK3/I -/I 8/I ),/O we/O isolated/O a/O 2022/I bp/I cDNA/I (/I VrCDPK/I -/I 1/I )/I from/O a/O Vigna/O radiata/O lambda/O gt11/O library/O ./O
However/O ,/O in/O TF/O -/O 1/O cells/O grown/O on/O GM/I -/I CSF/I before/O starvation/O ,/O CREB/I phosphorylation/O was/O observed/O 10/O minutes/O after/O PIXY321/I stimulation/O ./O
Workplace/O violence/O --/O nurses/O at/O risk/O ./O
RESULTS/O :/O The/O LV/O maximum/O brightness/O and/O area/O under/O the/O curve/O showed/O significant/O negative/O correlations/O (/O p/O =/O /O 40/O micrograms/O //O L/O and/O DAI/O >/O 150/O micrograms/O //O L/O )./O
Although/O the/O RAD23/I equivalents/O are/O well/O conserved/O during/O evolution/O ,/O the/O mammalian/O genes/O did/O not/O express/O the/O UV/O -/O inducible/O phenotype/O of/O their/O yeast/O counterpart/O ./O
Ha/I -/I RasV12/I and/O activated/O proteins/O in/O both/O the/O extra/I -/I cellular/I regulated/I kinase/I (/O ERK/I )/O and/O the/O stress/I -/I activated/I protein/I kinase/I (/O SAPK/I )/O or/O Jun/I N/I -/I terminal/I kinase/I (/O JNK/I )/O cascades/O independently/O stimulated/O PEA3/I -/O mediated/O gene/O expression/O ./O
Sequence/O analysis/O of/O reverse/O transcribed/O ,/O amplified/O cDNA/O generated/O from/O total/O RNA/O isolated/O from/O transfected/O cells/O demonstrated/O the/O presence/O of/O abnormally/O spliced/O products/O containing/O 13/O and/O 78/O additional/O bases/O as/O well/O as/O the/O accumulation/O of/O unspliced/O mRNA/O ./O
Its/O hydropathy/O profile/O predicts/O seven/O transmembrane/O spans/O and/O a/O hydrophilic/O amino/O terminus/O of/O approximately/O 100/O residues/O ,/O and/O it/O suggests/O the/O presence/O of/O an/O amphiphilic/O alpha/O -/O helix/O (/O L/O -/O 61/O to/O F/O -/O 97/O )/O in/O close/O proximity/O to/O the/O first/O strongly/O hydrophobic/O segment/O of/O ProW/I ./O
A/O 1/O ./O 5/O -/O kb/O HindIII/I genomic/O fragment/O carrying/O the/O vspA/I gene/O from/O M/O ./O bovis/O PG45/O was/O cloned/O and/O sequenced/O ./O
Carbon/O catabolite/O repression/O of/O the/O gnt/I operon/I of/I Bacillus/I subtilis/I is/O mediated/O by/O the/O catabolite/O control/O protein/O CcpA/I and/O by/O HPr/I ,/O a/O phosphocarrier/O protein/O of/O the/O phosphotransferase/O system/O ./O
Melatonin/O and/O seasonality/O :/O filling/O the/O gap/O ./O
A/O subsequent/O screen/O for/O the/O loss/O of/O the/O positively/O selectable/O target/O locus/O marker/O detects/O the/O desired/O replacement/O at/O modest/O frequency/O (>/O 2/O %)./O
Here/O we/O demonstrate/O that/O another/O cellular/O protein/O linked/O to/O BCR/I //O ABL/I through/O the/O CRKL/I -/O SH2/I domain/O is/O p130/I (/O CAS/I )./O p130/I (/O CAS/I )/O was/O found/O to/O be/O tyrosine/O phosphorylated/O and/O associated/O with/O CRKL/I in/O BCR/I //O ABL/I expressing/O cell/O lines/O and/O in/O samples/O obtained/O from/O CML/O and/O ALL/O patients/O ,/O but/O not/O in/O samples/O from/O controls/O ./O
There/O are/O four/O polyglutamine/O motifs/O interspersed/O with/O histidine/O -/O rich/O regions/O ./O
The/O effects/O of/O procedural/O variations/O on/O lateralized/O Stroop/O effects/O ./O
In/O a/O third/O experiment/O ,/O a/O Chessmaster/O gradually/O increases/O the/O number/O of/O boards/O he/O can/O reproduce/O with/O higher/O than/O 70/O %/O average/O accuracy/O to/O nine/O ,/O replacing/O as/O many/O as/O 160/O pieces/O correctly/O ./O
PCNA/I mRNA/I has/O a/O 3/O '/O UTR/O antisense/O to/O yellow/O crescent/O RNA/O and/O is/O localized/O in/O ascidian/O eggs/O and/O embryos/O ./O
A/O 1/O ./O 8/O -/O kb/O cDNA/O clone/O (/O designed/O hKID/I ,/O gene/I symbol/I AQP2L/I )/O with/O homology/O to/O the/O aquaporins/I was/O isolated/O from/O a/O human/O kidney/O cDNA/O library/O ./O
PCR/O //O Southern/O blot/O analysis/O of/O human/O kidney/O cDNA/O using/O primers/O flanking/O the/O hKID/I coding/I sequence/I revealed/O expression/O of/O a/O full/O -/O length/O mRNA/O and/O short/O transcripts/O with/O partial/O exon/O 1/O and/O partial/O exon/O 4/O deletions/O ./O
The/O high/O sequence/O homology/O ,/O similar/O genomic/O structure/O ,/O and/O identical/O chromosomal/O loci/O of/O hKID/I ,/O MIP/I ,/O and/O AQP/I -/I 2/I suggest/O a/O MIP/I family/I gene/I cluster/I at/O chromosome/O locus/O 12q13/O ./O
The/O third/O ORF/O generates/O a/O transcript/O of/O 1/O ./O 6/O kb/O and/O encodes/O a/O protein/O of/O 382/O residues/O including/O a/O perfect/O match/O to/O the/O consensus/O sequence/O of/O a/O C2H2/O zinc/O finger/O domain/O ;/O it/O shares/O a/O strong/O homology/O with/O yeast/I Mig1p/I and/O Cre/I -/I A/I from/I Aspergillus/I ,/I Emericella/I and/I E/I ./I coli/I ./O
Adding/O phytase/I and/O nP/O improved/O the/O orderliness/O of/O development/O ,/O mineralization/O and/O arrangement/O of/O cartilage/O and/O bone/O cells/O ,/O and/O alleviated/O the/O effects/O of/O P/O deficiency/O on/O the/O histological/O and/O gross/O structure/O of/O the/O tibias/O ./O
The/O importance/O of/O temporal/O factors/O on/O the/O presence/O and/O severity/O of/O ethanol/O withdrawal/O signs/O in/O the/O rat/O was/O quantified/O using/O rating/O scale/O ,/O tremor/O ,/O and/O acoustic/O startle/O paradigms/O ./O
Data/O supported/O the/O brevity/O of/O the/O WISC/O -/O III/O short/O form/O and/O the/O criterion/O -/O related/O validity/O of/O both/O the/O K/O -/O FAST/O and/O and/O Kaufman/O Short/O Neuropsychological/O Assessment/O Procedure/O (/O K/O -/O SNAP/O )./O
Quantitative/O analysis/O of/O plasmid/O loss/O rates/O in/O cdc28/I -/I 1N/I strains/O carrying/O plasmids/O with/O multiple/O replication/O origins/O suggests/O that/O a/O defect/O in/O initiating/O DNA/O replication/O probably/O causes/O this/O plasmid/O loss/O phenotype/O ./O
Thus/O ,/O the/O multidomained/O ROK/I alpha/I appears/O to/O be/O involved/O in/O reorganization/O of/O the/O cytoskeleton/O ,/O with/O the/O N/O and/O C/O termini/O acting/O as/O positive/O and/O negative/O regulators/O ,/O respectively/O ,/O of/O the/O kinase/O domain/O whose/O activity/O is/O crucial/O for/O formation/O of/O stress/O fibers/O and/O focal/O adhesion/O complexes/O ./O
These/O findings/O and/O the/O differential/O tissue/O distribution/O of/O p54/I suggest/O that/O this/O novel/O SR/I protein/I may/O participate/O in/O regulation/O of/O alternative/O splicing/O in/O a/O tissue/O -/O and/O substrate/O -/O dependent/O manner/O ./O
The/O elevation/O of/O cyclic/O AMP/O (/O cAMP/O )/O levels/O in/O the/O cell/O downregulates/O the/O activity/O of/O the/O Raf/I -/I 1/I kinase/I ./O
An/O interaction/O screen/O with/O the/O repression/O domain/O of/O the/O orphan/I receptor/I RevErb/I identified/O N/I -/I CoR/I ,/O the/O corepressor/O for/O thyroid/I hormone/I receptor/I (/O TR/I )/O and/O retinoic/I acid/I receptor/I (/O RAR/I )./O
These/O results/O indicate/O that/O inhibition/O of/O Jun/I kinase/I activation/O was/O sufficient/O to/O inhibit/O Ras/I transformation/O even/O in/O the/O presence/O of/O activated/O Erk/I -/I 2/I ./O
Our/O analysis/O suggests/O that/O Upf1p/I is/O a/O multifunctional/O protein/O with/O separable/O activities/O that/O can/O affect/O mRNA/O turnover/O and/O nonsense/O suppression/O ./O
Identification/O of/O Ste4/I as/O a/O potential/O regulator/O of/O Byr2/I in/O the/O sexual/O response/O pathway/O of/O Schizosaccharomyces/O pombe/O ./O
Two/O closely/O related/O variants/O of/O Stat5/I ,/O Stat5a/I and/O Stat5b/I ,/O are/O encoded/O by/O distinct/O genes/O ./O
Mutations/O in/O three/O loci/O (/O SIC1/I ,/O SWI5/I ,/O and/O RIC3/I )/O were/O identified/O ./O
The/O serine/I //I threonine/I kinase/I Raf/I -/I 1/I functions/O downstream/O of/O Rats/I in/O a/O signal/O transduction/O cascade/O which/O transmits/O mitogenic/O stimuli/O from/O the/O plasma/O membrane/O to/O the/O nucleus/O ./O
Platelet/I -/I derived/I growth/I factor/I -/O dependent/O activation/O of/O phosphatidylinositol/I 3/I -/I kinase/I is/O regulated/O by/O receptor/O binding/O of/O SH2/I -/I domain/I -/I containing/I proteins/I which/O influence/O Ras/I activity/O ./O
In/O transient/O cotransfections/O E1A/I could/O induce/O the/O activity/O of/O the/O p53/I promoter/I to/O a/O high/O level/O ;/O 12S/I E1A/I was/O threefold/O as/O efficient/O as/O 13S/I E1A/I in/O this/O activity/O ,/O and/O YY1/I bound/O to/O the/O composite/O element/O was/O shown/O to/O mediate/O 55/O %/O of/O this/O induction/O ./O
The/O retinoid/I Z/I receptor/I beta/I (/O RZR/I beta/I ),/O an/O orphan/O receptor/O ,/O is/O a/O member/O of/O the/O retinoic/I acid/I receptor/I (/O RAR/I )//O thyroid/I hormone/I receptor/I (/O TR/I )/O subfamily/O of/O nuclear/O receptors/O ./O
DNA/I -/I dependent/I protein/I kinase/I (/O DNA/I -/I PK/I )/O consists/O of/O a/O heterodimeric/O protein/O (/O Ku/I )/O and/O a/O large/O catalytic/O subunit/O (/O DNA/I -/I PKcs/I )./O
Almost/O complete/O sequence/O identity/O was/O found/O between/O the/O 3/O '/O end/O of/O the/O DXS6673E/I gene/I and/O two/O expressed/O sequence/O tags/O (/O ESTs/O )/O and/O between/O the/O 5/O '/O end/O of/O the/O DXS6673E/I gene/I and/O a/O third/O EST/O ./O
Sequencing/O of/O the/O 16p/O 11/O ./O 1/O //O Xq28/O duplication/O breakpoints/O has/O revealed/O the/O presence/O of/O repetitive/O immunoglobulin/I -/I like/I CAGGG/I pentamer/I sequences/I at/O or/O near/O the/O paralogy/O boundaries/O ./O
However/O ,/O in/O a/O multivariate/O analysis/O considering/O age/O ,/O gender/O ,/O and/O a/O previous/O history/O of/O cardiovascular/O diseases/O ,/O female/O gender/O was/O not/O independently/O associated/O with/O death/O ./O
Moreover/O ,/O following/O a/O single/O intravenous/O injection/O of/O the/O bicistronic/O vector/O complexed/O to/O cationic/O liposomes/O into/O recipient/O mice/O ,/O delivery/O of/O MDR1/I and/O GC/I cDNAs/I was/O achieved/O in/O all/O the/O organs/O we/O tested/O ./O
The/O limits/O of/O agreement/O between/O DBS/O and/O TOF/O responses/O were/O so/O wide/O that/O they/O cannot/O be/O used/O interchangeably/O ./O
The/O harpin/I -/O encoding/O hrpZ/I gene/I is/O located/O in/O an/O operon/O that/O also/O encodes/O Hrp/I secretion/I pathway/I components/I and/O is/O part/O of/O the/O functional/O cluster/O of/O hrp/I genes/I carried/O on/O cosmid/O pHIR11/O that/O enables/O saprophytic/O bacteria/O like/O Escherichia/O coli/O and/O Pseudomonas/O fluorescens/O to/O elicit/O the/O HR/O in/O tobacco/O leaves/O ./O
Despite/O the/O presence/O of/O one/O additional/O ribonucleotide/I reductase/I ,/O the/O nrdAB/I -/I encoded/I enzyme/I is/O essential/O to/O the/O aerobic/O growth/O of/O the/O cell/O because/O nrdAB/I -/I defective/I mutants/I of/O both/O species/O are/O not/O viable/O in/O the/O presence/O of/O oxygen/O ./O
Altogether/O ,/O the/O results/O demonstrate/O that/O the/O two/O isoforms/O elicit/O similar/O responses/O in/O vivo/O despite/O differences/O in/O their/O regulation/O ./O
Motivational/O factors/O focusing/O on/O attitudes/O ,/O perceived/O susceptibility/O to/O pregnancy/O ,/O and/O normative/O factors/O were/O also/O relevant/O ./O
High/O -/O resolution/O structure/O of/O the/O diphtheria/I toxin/I repressor/I complexed/O with/O cobalt/O and/O manganese/O reveals/O an/O SH3/I -/I like/I third/O domain/O and/O suggests/O a/O possible/O role/O of/O phosphate/O as/O co/O -/O corepressor/O ./O
Titration/O of/O the/O human/O and/O porcine/O proteins/O with/O 2/O -/O nitro/O -/O 5/O -/O thiosulfabenzoate/O indicates/O that/O membrane/I dipeptidase/I additionally/O possesses/O two/O intrachain/O disulfide/O bonds/O ./O
FEV1/O did/O not/O fall/O significantly/O in/O patients/O without/O acute/O or/O chronic/O GVHD/O and/O recovered/O earlier/O than/O in/O patients/O without/O posttransplant/O pulmonary/O infection/O ./O
Administration/O of/O adrenaline/O resulted/O in/O a/O large/O overestimation/O of/O the/O SaO2/O in/O 6/O of/O the/O 7/O measurements/O ./O
Therapy/O with/O dietary/O modification/O and/O triglyceride/O lowering/O drugs/O resulted/O in/O resolution/O of/O symptoms/O and/O parotid/O swelling/O in/O one/O patient/O ./O
Chernoff/O ,/O submitted/O for/O publication/O )./O
We/O have/O cloned/O a/O novel/O protein/O kinase/O ,/O termed/O hematopoietic/I progenitor/I kinase/I 1/I (/O HPK1/I ),/O that/O is/O expressed/O predominantly/O in/O hematopoietic/O cells/O ,/O including/O early/O progenitor/O cells/O ./O
Human/O ESP1/I //O CRP2/I protein/O has/O two/O LIM/I domains/O ,/O and/O each/O shares/O 35/O ./O 1/O %/O and/O 77/O or/O 79/O %/O identical/O residues/O with/O human/I cysteine/I -/I rich/I protein/I (/O CRP/I )/O and/O rat/I CRIP/I ,/O respectively/O ./O
The/O fragments/O are/O separated/O and/O directly/O sized/O by/O agarose/O gel/O electrophoresis/O ./O
Several/O of/O the/O exon/O boundaries/O correspond/O to/O the/O boundaries/O of/O functional/O domains/O in/O the/O p55/I protein/I ./O
Linkage/O studies/O have/O shown/O locus/O heterogeneity/O with/O one/O TSC/I gene/I mapped/O to/O chromosome/O 9q34/O and/O a/O second/O to/O 16p13/O ./O 3/O ./O
The/O cytogenetic/O expression/O of/O the/O folate/O sensitive/O fragile/O site/O ,/O FRAXE/I ,/O is/O due/O to/O the/O expansion/O of/O a/O GCC/O repeat/O in/O proximal/O Xq28/O of/O the/O human/O X/O chromosome/O and/O is/O associated/O with/O a/O mild/O form/O of/O mental/O handicap/O ./O
DNA/O sequence/O analysis/O of/O a/O 3213/O bp/O BamHI/I -/O ClaI/I fragment/O revealed/O that/O three/O open/O reading/O frames/O (/O ORFs/O )/O were/O encoded/O in/O the/O same/O orientation/O ./O
The/O initial/O inpatient/O experience/O for/O individuals/O with/O HIV/O -/O related/O TB/O may/O be/O pivotal/O to/O the/O acceptance/O of/O and/O participation/O in/O ongoing/O TB/O care/O ./O
Tristetraprolin/I (/O TTP/I )/O is/O the/O prototype/O of/O a/O group/O of/O potential/O transcription/O factors/O that/O contain/O two/O or/O more/O unusual/O CCCH/O zinc/O fingers/O ./O
This/O element/O ,/O termed/O CREsp/O -/O a/O (/O TGACCTCA/O ),/O differs/O by/O one/O nucleotide/O from/O a/O palindromic/O CRE/O (/O CREpal/O ,/O TGACGTCA/O ),/O which/O is/O known/O to/O bind/O CREB/I as/O a/O homodimer/O ./O
Analysis/O of/O human/O genomic/O DNA/O reveals/O an/O intronless/O sequence/O with/O strong/O homology/O to/O human/I G/I alpha/I q/I cDNA/I ./O
The/O complete/O exon/O -/O intron/O structure/O of/O the/O 156/I -/I kb/I human/I gene/I NFKB1/I ,/O which/O encodes/O the/O p105/I and/O p50/I proteins/I of/O transcription/O factors/O NF/I -/I kappa/I B/I and/O I/I kappa/I B/I -/I gamma/I :/O implications/O for/O NF/I -/I kappa/I B/I -/O mediated/O signal/O transduction/O ./O
An/O inverted/O Alu/I repeat/O element/O ,/O flanked/O by/O nonamer/O direct/O repeats/O ,/O was/O identified/O within/O the/O region/O -/O 913/O /-/O 620/O ,/O relative/O to/O the/O cap/O site/O ./O
The/O ewes/O were/O returned/O to/O normoxia/O ,/O and/O monitoring/O was/O continued/O for/O 1/O h/O ./O
Feline/O leukemia/O viruses/O (/O FeLVs/O ),/O which/O are/O replication/O -/O competent/O oncoretroviruses/O of/O the/O domestic/O cat/O species/O ,/O are/O contagiously/O transmitted/O in/O natural/O environments/O ./O
Comparison/O of/O the/O amino/O acid/O sequences/O of/O the/O RPO1/I polypeptides/I of/I IIV6/I ,/I LCDV/I ,/I and/I MCV/I -/I 1/I with/O the/O corresponding/O prokaryotic/O ,/O eukaryotic/O ,/O and/O viral/O proteins/O revealed/O differences/O in/O amino/O acid/O similarity/O and/O phylogenetic/O relationships/O ./O
The/O RPO1/I of/O LCDV/O shows/O the/O highest/O similarity/O to/O the/O RPO1/I of/O IIV6/O and/O significant/O lower/O similarity/O to/O the/O eukaryotic/I polymerases/I II/I and/I III/I as/O well/O as/O to/O the/O archaebacteral/O subunit/O ./O
The/O use/O of/O primary/O GE/O cells/O thus/O provides/O a/O convenient/O in/O vitro/O system/O for/O further/O study/O of/O the/O endocrine/O ,/O paracrine/O ,/O and/O autocrine/O factors/O regulating/O endometrial/O gene/O expression/O during/O pregnancy/O ./O
We/O performed/O dipole/O estimation/O of/O spikes/O and/O SEP/O components/O in/O identical/O patients/O ./O
Both/O verapamil/O and/O propranolol/O can/O exhibit/O additive/O effects/O with/O adenosine/O in/O prolonging/O AV/O nodal/O conduction/O time/O ;/O however/O ,/O only/O verapamil/O can/O reduce/O the/O dose/O of/O adenosine/O required/O to/O produce/O AV/O nodal/O block/O ./O
Proximal/O CBD/O was/O inversely/O correlated/O with/O bone/I alkaline/I phosphatase/I (/O r/O =/O -/O 0/O ./O 71/O ,/O p/O /I 4/I )-/I beta/I -/I xylan/I endohydrolase/I isoenzyme/I X/I -/I I/I ./O
Magnetic/O resonance/O imaging/O in/O coccidioidal/O arthritis/O ./O
Moloney/O murine/O leukemia/O virus/O (/O MMLV/O )-/O derived/O pUCMoTiN/O -/O based/O retroviral/O vectors/O were/O engineered/O to/O allow/O constitutive/O and/O Tat/I (/O trans/I -/I activator/I of/I transcription/I )-/O inducible/O expression/O of/O five/O hammerhead/O ribozymes/O targeted/O against/O highly/O conserved/O sequences/O within/O the/O group/I antigen/I (/O Gag/I ),/O protease/I (/O Pro/I ),/O reverse/I transcriptase/I (/O RT/I ),/O tat/I ,/O and/O envelope/I (/O Env/I )/O coding/O regions/O of/O human/O immunodeficiency/O virus/O type/O -/O 1/O (/O HIV/O -/O 1/O )/O RNA/O ./O
REM/O sleep/O deprivation/O was/O performed/O using/O the/O platform/O technique/O ./O
The/O same/O ligands/O also/O exhibit/O a/O similar/O inhibitory/O effect/O on/O PDGF/I -/I BB/I -/O dependent/O [/O 3H/O ]/O thymidine/O incorporation/O in/O PAE/O cells/O expressing/O the/O PDGF/I beta/I -/I receptors/I ./O
We/O analyzed/O serial/O biopsy/O specimens/O from/O eight/O patients/O with/O FL/O for/O secondary/O alterations/O of/O the/O rearranged/I bcl/I -/I 2/I gene/I in/O the/O breakpoint/O and/O open/O reading/O frame/O (/O ORF/O )/O regions/O ./O
In/O all/O eight/O cases/O ,/O neither/O FL/O nor/O DLL/O cells/O showed/O alterations/O of/O bcl/I -/I 2/I gene/I sequences/I in/O the/O breakpoint/O region/O ,/O suggesting/O high/O conservation/O of/O the/O bcl/I -/I 2/I gene/I during/O both/O t/O (/O 14/O ;/O 18/O )/O translocation/O and/O morphologic/O transformation/O of/O the/O FL/O cells/O ./O
BACKGROUND/O :/O The/O Bazett/O -/O corrected/O QT/O (/O QTc/O )/O interval/O during/O exercise/O has/O been/O used/O as/O a/O marker/O for/O ischemic/O disease/O ,/O arrhythmogenic/O substrate/O and/O the/O long/O QT/O syndrome/O ./O
An/O essential/O role/O of/O c/I -/I Jun/I and/O c/I -/I Fos/I in/O basal/O and/O PMA/O -/O stimulated/O transcription/O of/O the/O PAI/I -/I 1/I gene/I is/O demonstrated/O by/O our/O finding/O that/O antisense/O c/I -/I jun/I and/O c/I -/I fos/I oligodeoxynucleotides/O both/O strongly/O reduced/O basal/O and/O PMA/O -/O stimulated/O PAI/I -/I 1/I synthesis/O ./O
Leukemia/I -/I inhibitory/I factor/I (/O LIF/I )/O is/O a/O neuropoietin/I able/O to/O regulate/O the/O differentiation/O and/O the/O survival/O of/O many/O cell/O types/O ,/O which/O include/O some/O neuronal/O populations/O ./O
To/O analyze/O the/O mechanism/O of/O fos/I //O jun/I activation/O by/O TCDD/O we/O have/O used/O electrophoretic/O mobility/O shift/O and/O transient/O expression/O assays/O of/O reporter/O gene/O constructs/O containing/O response/O elements/O for/O 12/O -/O O/O -/O tetradecanoyl/O -/O phorbol/O -/O 13/O -/O acetate/O (/O TRE/O ),/O serum/O (/O SRE/O ),/O cAMP/O (/O CRE/O ),/O and/O aromatic/O hydrocarbons/O (/O AhRE/O )/O from/O the/O fos/I and/O jun/I genes/I fused/O to/O the/O firefly/I luciferase/I gene/I under/O the/O control/O of/O the/O SV40/I minimal/I promoter/I ./O
The/O optimal/O sequence/O for/O interaction/O with/O mu/I 2/I and/O with/O AP/I -/I 2/I has/O tyrosine/O as/O an/O anchor/O and/O prefers/O arginine/O at/O position/O Y/O +/O 2/O and/O leucine/O at/O position/O Y/O +/O 3/O ./O
STK/I //O RON/I -/O expressing/O Ba/O //O F3/O pro/O -/O B/O cells/O (/O BaF/O //O STK/I )/O exhibited/O MSP/I -/O dependent/O growth/O ,/O whereas/O STK/I //O RON/I -/O expressing/O mouse/O erythroleukaemia/O cells/O (/O MEL/O //O STK/I )/O displayed/O MSP/I -/O induced/O apoptosis/O ./O
In/O vitro/O DNase/I I/I footprinting/O showed/O that/O OxyR/I -/I C199S/I protected/O Pmom/I from/O -/O 104/O to/O -/O 46/O on/O the/O top/O strand/O and/O produced/O a/O protection/O pattern/O characteristic/O of/O reduced/I wild/I -/I type/I OxyR/I ./O
Kss1/I binds/O specifically/O to/O a/O GST/I -/O Dig1/I fusion/O in/O the/O absence/O of/O any/O other/O yeast/O protein/O ./O
In/O contrast/O ,/O dig1/I dig2/I cells/O constitutively/O invade/O agar/O medium/O ,/O whereas/O a/O dig1/I dig2/I ste12/I triple/O mutant/O does/O not/O ,/O indicating/O that/O Dig1/I and/O Dig2/I share/O a/O role/O in/O negatively/O regulating/O the/O invasive/O growth/O pathway/O ./O
Paracrine/O activation/O of/O the/O HIV/I -/I 1/I LTR/I promoter/I by/O the/O viral/I Tat/I protein/I is/O mechanistically/O similar/O to/O trans/O -/O activation/O within/O a/O cell/O ./O
Comparison/O of/O the/O sequences/O of/O the/O xFxFG/O repeat/O regions/O of/O p62/I and/O Nsplp/I indicated/O that/O NTF2/I was/O probably/O interacting/O with/O the/O phenylalanine/O -/O containing/O core/O of/O these/O repeats/O and/O not/O the/O intervening/O hydrophilic/O linkers/O ./O
This/O is/O the/O first/O report/O of/O the/O successful/O resection/O of/O a/O MFH/O originating/O in/O the/O renal/O capsular/O tissue/O and/O extending/O into/O the/O inferior/O vena/O cava/O ./O
Transient/O expression/O of/O VSF/I -/I 1/I in/O protoplasts/O stimulated/O vs/I -/I 1/I dependent/O activation/O of/O the/O -/I 76/I //I grp1/I ./I 8/I minimal/I promoter/I ./O
Keeping/O in/O mind/O the/O limited/O range/O of/O age/O and/O dosages/O ,/O advantages/O and/O disadvantages/O of/O the/O drug/O are/O discussed/O ,/O comparing/O the/O experimental/O results/O with/O those/O derived/O from/O the/O literature/O ./O
Blood/O sampling/O procedures/O were/O videotaped/O ./O
Analysis/O of/O one/O cDNA/O revealed/O an/O unusual/O splicing/O event/O involving/O EZH1/I and/O a/O tandemly/O linked/O gene/O GPR2/I and/O suggests/O a/O potential/O mechanism/O for/O modifying/O the/O EZH1/I protein/I in/O the/O conserved/O C/O -/O terminal/O domain/O ./O
A/O given/O standard/O input/O function/O and/O a/O given/O value/O of/O distribution/O volume/O (/O Vd/O )/O used/O for/O the/O rCBF/O measurement/O of/O this/O method/O were/O calculated/O from/O the/O dynamic/O study/O by/O six/O normal/O volunteers/O ./O
They/O lack/O a/O predicted/O single/O stranded/O (/O ss/O )/O DNA/O binding/O motif/O that/O is/O unique/O the/O large/O terminase/I proteins/I in/O T4/I gp17/I ,/O and/O that/O has/O been/O implicated/O in/O recognizing/O ssDNA/O regions/O in/O replicating/O and/O recombining/O T4DNA/O destined/O to/O be/O packaged/O ./O
It/O can/O be/O concluded/O that/O in/O normotensive/O subjects/O ,/O uric/O acid/O and/O xanthine/I oxidase/I have/O significant/O association/O with/O blood/O pressure/O and/O thus/O are/O one/O of/O the/O many/O factors/O which/O are/O involved/O in/O the/O cause/O or/O effect/O of/O hypertension/O ./O
Immunoblotting/O of/O expressed/O recombinant/O proteins/O with/O the/O monoclonal/I 08L/I antibody/I localized/O the/O 08L/I epitope/O to/O the/O carboxyl/O end/O of/O the/O protein/O ./O
We/O infer/O that/O the/O dominant/O negative/O inhibition/O results/O from/O both/O direct/O proteolysis/O of/O the/O beta/I -/I galactosidase/I tetramer/I by/O the/O fusion/O subunit/O and/O detour/O of/O the/O tetramer/O to/O the/O lysosome/O ./O
The/O current/O study/O defines/O the/O vinculin/I -/O and/O FAK/I -/I interaction/I domains/I on/O paxillin/I and/O identifies/O the/O principal/O paxillin/I focal/O adhesion/O targeting/O motif/O ./O
These/O data/O demonstrate/O the/O presence/O of/O a/O single/O binding/O site/O for/O vinculin/I ,/O and/O at/O least/O two/O binding/O sites/O for/O FAK/I that/O are/O separated/O by/O an/O intervening/O stretch/O of/O 100/O amino/O acids/O ./O
These/O data/O demonstrate/O that/O paxillin/I localizes/O to/O focal/O adhesions/O independent/O of/O interactions/O with/O vinculin/I and/O //O or/O FAK/I ,/O and/O represents/O the/O first/O definitive/O demonstration/O of/O LIM/I domains/I functioning/O as/O a/O primary/O determinant/O of/O protein/O subcellular/O localization/O to/O focal/O adhesions/O ./O
A/O single/O protease/O -/O resistant/O structure/O formed/O by/O the/O entirety/O of/O both/O PDZ/I repeats/I 1/I and/I 2/I (/O PDZ1/I -/I 2/I )/O contains/O the/O protein/I 4/I ./I 1/I -/I binding/I site/I ./O
Several/O agents/O have/O been/O tried/O for/O treatment/O ,/O often/O limited/O by/O toxic/O side/O effects/O ./O
Jerseys/O had/O higher/O hepatic/O Cu/O concentrations/O than/O did/O Holsteins/O on/O d/O 60/O (/O 346/O vs/O ./O
RUSH/I -/I 1/I beta/I is/O a/O 95/O -/O kDa/O truncated/O version/O of/O RUSH/I -/I 1/I alpha/I that/O results/O from/O alternative/O splicing/O of/O a/O 57/O -/O bp/O exon/O as/O confirmed/O by/O genomic/O cloning/O ./O
These/O results/O are/O consistent/O with/O the/O well/O established/O polarity/O of/O RXR/I heterodimer/O binding/O to/O bipartite/O hormone/O response/O elements/O ,/O with/O the/O VDR/I recognizing/O the/O 3/O '-/O half/O -/O element/O ./O
PPAR/I gamma/I mRNA/I levels/O were/O reduced/O by/O 95/O %/O with/O 3/O nM/O TNF/I alpha/I treatment/O for/O 24/O h/O ./O
Exons/O III/O to/O VIII/O ,/O which/O cover/O the/O coding/O region/O and/O the/O 3/O '/O untranslated/O region/O ,/O are/O almost/O identical/O in/O all/O types/O of/O PST/I or/O AST/I cDNAs/I ./O
Growth/O factor/O allows/O effective/O dose/O -/O intensive/O regimen/O in/O advanced/O breast/O cancer/O patients/O ./O
Recombinant/I erythropoietin/I (/O r/I -/I HuEPO/I )/O in/O the/O treatment/O of/O anemia/O in/O multiple/O myeloma/O
In/O 1993/O and/O 1994/O and/O infection/O with/O body/O lice/O was/O registered/O 41/O times/O in/O 31/O patients/O at/O the/O clinic/O for/O homeless/O of/O the/O Community/O Health/O Service/O of/O Utrecht/O ./O
Ki/I -/I ras/I and/O p53/I mutations/I in/O pancreatic/O ductal/O adenocarcinoma/O ./O
Epidemiological/O data/O are/O quite/O controversial/O but/O sudden/O death/O occurring/O during/O sporting/O activity/O is/O probably/O not/O a/O rare/O occurrence/O ./O
However/O ,/O the/O ratio/O M/O //O Pc/O provides/O a/O useful/O index/O that/O seems/O to/O be/O independent/O of/O the/O metabolic/O demand/O ./O
Rat/I liver/I catalase/I is/O sorted/O to/O peroxisomes/O by/O its/O C/O -/O terminal/O tripeptide/O Ala/O -/O Asn/O -/O Leu/O ,/O not/O by/O the/O internal/O Ser/O -/O Lys/O -/O Leu/O motif/O ./O
The/O mobility/O shift/O assay/O of/O the/O 65/O bp/O (-/O 318/O //O -/O 254/O )/O fragment/O with/O nuclear/O extract/O from/O the/O dark/O -/O adapted/O sample/O showed/O an/O additional/O band/O ,/O not/O seen/O with/O the/O light/O -/O grown/O sample/O ./O
These/O data/O provide/O strong/O evidence/O that/O E2F/I or/O an/O E2F/I -/I related/I transcription/I factor/I is/O involved/O in/O the/O regulation/O of/O nonmuscle/I myosin/I expression/O ./O
When/O the/O E1A/I N/I -/I terminus/I is/O used/O as/O a/O competitor/O in/O squelshing/O experiments/O it/O abolishes/O CBP/I -/O induced/O activation/O of/O E2F1/I //O DP1/I ,/O whereas/O an/O E1A/I mutant/I lacking/O CBP/I binding/O ability/O fails/O to/O do/O so/O ./O
Small/O Maf/I proteins/I interact/O with/O the/O human/O transcription/O factor/O TCF11/I //O Nrf1/I //O LCR/I -/I F1/I ./O
On/O the/O third/O occasion/O water/O (/O W/O )/O was/O ingested/O throughout/O the/O run/O ./O
The/O effect/O of/O maternal/O ingestion/O of/O the/O reduced/O energy/O sweetener/O erythritol/O was/O investigated/O in/O KBL/O :/O JW/O strain/O pregnant/O rabbits/O ./O
Moreover/O ,/O the/O same/O mutations/O alter/O the/O structure/O of/O junB/I 5/O '/O flanking/O DNA/O within/O chromatin/O ./O
The/O nm23/I -/I H1/I //O nm23/I -/I H2/I gene/O transcriptional/O activity/O ratio/O varied/O depending/O on/O the/O cell/O line/O ./O
CONCLUSION/O :/O Intravenous/O diazepam/O administration/O before/O EGD/O produces/O a/O significant/O fall/O in/O SpO2/O during/O the/O procedure/O ,/O and/O so/O should/O be/O avoided/O ;/O continuous/O monitoring/O of/O SpO2/O should/O be/O done/O during/O EGD/O ./O
The/O nucleotide/O sequence/O alignment/O between/O mouse/O and/O human/I CA/I IV/I shows/O 69/O %/O identity/O in/O the/O coding/O region/O and/O all/O of/O the/O exon/O -/O intron/O boundaries/O are/O conserved/O ,/O as/O are/O the/O sizes/O of/O the/O introns/O ./O
Discordance/O on/O the/O cost/O dimension/O correlated/O negatively/O with/O G/I Hb/I ,/O suggesting/O better/O glycemic/O control/O with/O greater/O disagreement/O ./O
DATA/O SOURCES/O :/O Epidemiologic/O studies/O ,/O research/O studies/O ,/O review/O articles/O ,/O and/O government/O reports/O pertaining/O to/O epidemiology/O of/O lung/O cancer/O ./O
RESULTS/O :/O The/O age/O distribution/O was/O 28/O to/O 83/O years/O old/O (/O mean/O was/O 54/O ./O 1/O years/O )./O
Histological/O changes/O ,/O including/O cortical/O cell/O involution/O and/O hemorrhage/O occurring/O during/O the/O neonatal/O period/O ,/O would/O seem/O to/O have/O crucial/O relevance/O to/O the/O remodeling/O of/O the/O adrenal/O vasculature/O ./O
Furthermore/O ,/O co/O -/O expression/O of/O both/O p46/I and/O p54/I subunits/I markedly/O altered/O the/O subcellular/O distribution/O of/O p46/I ;/O co/O -/O expressed/O p46/I was/O transported/O into/O the/O nucleus/O as/O efficiently/O as/O p54/I ./O
The/O results/O suggest/O that/O ,/O although/O both/O the/O N/O -/O and/O C/O -/O terminal/O regions/O of/O talin/I bind/O actin/I ,/O the/O properties/O of/O these/O two/O regions/O of/O the/O protein/O are/O distinct/O ./O
Merr/O .)/O embryo/O library/O ./O
The/O accumulation/O of/O both/O LHA4/I and/O LHA2/I mRNAs/I is/O induced/O by/O the/O addition/O of/O exogenous/O sugars/O and/O this/O induction/O appears/O to/O be/O dependent/O on/O sugar/O uptake/O and/O metabolism/O ,/O because/O mannitol/O and/O 3/O -/O O/O -/O methylglucose/O do/O not/O stimulate/O mRNA/O accumulation/O ./O
Using/O the/O yeast/O one/O -/O hybrid/O screen/O with/O integrated/O NRE/O and/O flanking/O DNA/O as/O bait/O ,/O the/O predominant/O clone/O obtained/O was/O bovine/I Nrl/I ./O
As/O the/O rate/O of/O protein/O synthesis/O decreases/O during/O late/O embryogenesis/O ,/O levels/O of/O SEC/I -/I 1/I and/O its/O cognate/O mRNA/O decline/O precipitously/O ./O
These/O findings/O suggest/O that/O fodrin/I proteolysis/O in/O vivo/O may/O reflect/O the/O activity/O of/O multiple/O ICE/I //O Ced/I -/I 3/I proteases/O whose/O partial/O sensitivity/O to/O DEVD/O -/O CHO/O reflects/O a/O limited/O contribution/O from/O CPP32/I ,/O or/O an/O ICE/I //O Ced/I -/I 3/I protease/O less/O sensitive/O than/O CPP32/I to/O DEVD/O -/O CHO/O inhibition/O ./O
In/O 3Y1/O and/O 3Y1/O v/I -/I crk/I -/O transformed/O fibroblasts/O ,/O almost/O all/O of/O the/O total/O PTP1B/I and/O about/O 40/O %/O of/O total/O p130/I (/O Cas/I )/O co/O -/O sediment/O with/O membranes/O composed/O primarily/O of/O endoplasmic/O reticulum/O ./O
Replacing/O residues/O 405/O -/O 419/O on/O delta419/O with/O the/O conserved/O AF/O -/O 2/O domain/O from/O the/O vitamin/I D3/I receptor/I or/O the/O estrogen/I receptor/I results/O in/O a/O receptor/O with/O wild/O -/O type/O or/O low/O transcriptional/O activity/O ,/O respectively/O ./O
Recurrent/O G/O -/O to/O -/O A/O substitution/O in/O a/O single/O codon/O of/O SREBP/I cleavage/I -/I activating/I protein/I causes/O sterol/O resistance/O in/O three/O mutant/O Chinese/O hamster/O ovary/O cell/O lines/O ./O
The/O Escherichia/I coli/I tet/I -/I repressor/I (/O TetR/I )/O operator/O system/O was/O used/O to/O develop/O a/O variation/O of/O the/O yeast/O two/O -/O hybrid/O assay/O in/O which/O disruptions/O of/O protein/O -/O protein/O interactions/O can/O be/O identified/O by/O a/O positive/O selection/O ./O
Recent/O studies/O have/O suggested/O that/O SHP/I -/I 1/I regulates/O the/O function/O of/O Jak/I family/O tyrosine/I kinases/I ,/O as/O shown/O by/O its/O constitutive/O association/O with/O the/O Tyk2/I kinase/I and/O the/O hyperphosphorylation/O of/O Jak/I kinases/I in/O the/O motheaten/O cells/O that/O lack/O functional/O SHP/I -/I 1/I ./O
Administration/O of/O a/O second/O dose/O of/O vaccine/O during/O the/O outbreak/O was/O not/O protective/O ./O
But/O ,/O as/O Theriault/O explains/O ,/O improvements/O in/O assessing/O exposure/O have/O not/O yet/O translated/O into/O clear/O and/O consistent/O findings/O ./O
Biol/O ./O
Structural/O basis/O for/O activation/O of/O human/I lymphocyte/I kinase/I Lck/I upon/O tyrosine/O phosphorylation/O ./O
Evolutive/O morphology/O of/O the/O olfactory/O bulb/O in/O man/O and/O certain/O non/O -/O human/O mammals/O
From/O these/O results/O ,/O we/O concluded/O that/O this/O ORF/O is/O the/O FRDS/I gene/I ./O
FK506/O is/O 10/O -/O to/O 100/O -/O fold/O more/O potent/O than/O cyclosporin/O A/O in/O preventing/O organ/O rejection/O and/O in/O toxicity/O ./O
These/O results/O suggest/O that/O Rho1p/I regulates/O cytoskeletal/O reorganization/O at/O least/O through/O Bni1p/I and/O Pkc1p/I ./O
The/O ERH/I expression/O profile/O is/O similar/O ,/O to/O that/O of/O An3/I ,/O which/O localizes/O to/O the/O animal/O hemisphere/O of/O oocytes/O and/O is/O abundantly/O expressed/O in/O the/O embryo/O ./O
Waves/O N1/O ,/O P3/O and/O CNV/O were/O recorded/O during/O a/O CNV/O paradigm/O in/O a/O simple/O reaction/O time/O task/O with/O a/O constant/O interstimulus/O interval/O (/O ISI/O )/O of/O 1/O sec/O ./O
Therefore/O ,/O both/O the/O Chilean/O and/O the/O Japanese/O samples/O collected/O in/O high/O -/O risk/O areas/O showed/O higher/O mutagenic/O rates/O than/O the/O Japanese/O ones/O in/O a/O low/O -/O risk/O area/O ,/O with/O a/O statistical/O significance/O (/O p/O /O A/O selectively/O binds/O only/O the/O subset/O of/O C/I //I EBP/I sites/I that/O are/O also/O DBP/I sites/I ,/O both/O as/O oligonucleotides/O and/O within/O the/O natural/O contexts/O of/O the/O albumin/I and/O cholesterol/I hydroxylase/I promoters/I ./O
Specific/O IgG/I ,/O specific/O IgE/I and/O total/O IgE/I immunoglobulins/I against/O Toxocara/I canis/I excretory/I //I secretory/I antigens/I (/O TES/I )/O were/O detected/O by/O using/O ELISA/O technique/O ./O
SUMMARY/O BACKGROUND/O DATA/O :/O Melanoma/O care/O has/O not/O changed/O significantly/O in/O the/O last/O 20/O years/O ,/O and/O the/O controversy/O of/O elective/O lymph/O node/O dissections/O in/O this/O disease/O continues/O to/O be/O discussed/O ./O
The/O differences/O among/O subgenera/O of/O the/O genus/O Dermacentor/O are/O more/O significant/O ./O
Mutating/O the/O E/O -/O box/O in/O the/O context/O of/O the/O 3/O '-/O flanking/O region/O confirmed/O that/O it/O contributes/O to/O the/O enhancement/O of/O transcriptional/O activity/O of/O the/O alpha1/I (/I I/I )/I collagen/I gene/I promoter/I ./O
Expression/O of/O neuronal/O traits/O in/O pancreatic/O beta/O cells/O ./O
We/O propose/O that/O Mnt/I :/O Max/I :/O Sin3/I complexes/O normally/O function/O to/O restrict/O Myc/I :/O Max/I activities/O associated/O with/O cell/O proliferation/O ./O
Its/O transcription/O product/O ,/O a/O 1/O ./O 3/O kb/O mRNA/O ,/O is/O polyadenylated/O at/O a/O site/O containing/O consensus/O eukaryotic/O polyadenylation/O signals/O and/O mapping/O 87/O bp/O downstream/O of/O the/O translation/O termination/O codon/O for/O CG30/I ./O
Phenotypic/O changes/O induced/O by/O wild/I type/I and/I variant/I c/I -/I src/I genes/I carrying/O C/O -/O terminal/O sequence/O alterations/O ./O
The/O resurgence/O of/O drug/O -/O resistant/O malaria/O makes/O urgent/O the/O evaluation/O of/O new/O antimalarial/O agents/O ./O
In/O the/O p51/I subunit/I ,/O the/O Cys181/O side/O -/O chain/O is/O oriented/O in/O a/O similar/O direction/O to/O the/O Tyr181/O side/O -/O chain/O in/O the/O wild/O -/O type/O complex/O ./O
The/O relatively/O high/O level/O transcription/O from/O this/O gene/O shows/O that/O the/O polymorphic/O chromosome/O ends/O of/O P/O ./O falciparum/O ,/O which/O have/O been/O proposed/O to/O be/O transcriptionally/O silent/O ,/O can/O be/O active/O expression/O sites/O for/O var/I genes/I ./O
NUP145/I was/O previously/O identified/O by/O using/O a/O genetic/O synthetic/O lethal/O screen/O (/O E/O ./O
Prevalence/O of/O sleep/O -/O disordered/O breathing/O (/O SDB/O )/O is/O reported/O to/O increase/O in/O menopausal/O women/O ./O
In/O all/O cases/O the/O antigenemia/O was/O transient/O and/O cleared/O by/O 28th/O day/O post/O -/O vaccination/O ./O
A/O total/O of/O 1459/O men/O aged/O 48/O to/O 84/O years/O ,/O who/O were/O diagnosed/O for/O the/O first/O time/O by/O physicians/O as/O having/O BPH/O in/O 1994/O and/O who/O had/O not/O received/O treatment/O ,/O participated/O in/O the/O study/O ./O
BCL/I -/I 2/I ,/O an/O inhibitor/O of/O apoptosis/O in/O a/O wide/O variety/O of/O cell/O types/O ,/O has/O been/O reported/O to/O prevent/O oxidative/O stress/O -/O induced/O cell/O death/O ./O
In/O vitro/O translation/O of/O the/O mTRF1/I cDNA/I resulted/O in/O a/O 56/O kDa/O protein/O that/O binds/O to/O TTAGGG/O repeat/O arrays/O ./O mTRF1/I displayed/O the/O same/O sequence/O specificity/O as/O hTRF1/I ,/O preferring/O arrays/O of/O TTAGGG/O repeats/O as/O a/O binding/O substrate/O over/O TTAGGC/O and/O TTGGGG/O repeats/O ./O
The/O ubiquitously/O expressed/O E12/I bHLH/I protein/I dimerizes/O with/O numerous/O cell/O -/O specific/O bHLH/I factors/I ./O
The/O E/O -/O box/O sequence/O in/O the/O SE2/I fragment/I of/O the/O transferrin/I promoter/I was/O CATCTG/O and/O was/O similar/O in/O gel/O shifts/O to/O the/O consensus/O E/O -/O box/O elements/O (/O CANNTG/O )/O previously/O characterized/O ./O
A/O 5/O ./O 3/O -/O kb/O DNA/O fragment/O ,/O which/O included/O the/O entire/O structural/O porin/I gene/I (/O named/O porCa/I )/O and/O its/O flanking/O regions/O ,/O was/O identified/O ./O
Full/I -/I length/I AT/I -/I PHH1/I ,/O and/O both/O AT/I -/I PHH1/I and/O AT/I -/I PHH1/I delta/I C/I -/I 513/I (/O truncated/O to/O be/O approximately/O the/O size/O of/O microbial/I photolyase/I genes/I )/O cDNAs/O ,/O were/O overexpressed/O ,/O respectively/O ,/O in/O yeast/O and/O Escherichia/O coli/O mutants/O hypersensitive/O to/O ultraviolet/O light/O ./O
The/O human/I p100/I protein/I was/O recently/O identified/O as/O a/O coactivator/O of/O the/O Epstein/I -/I Barr/I virus/I nuclear/I antigen/I 2/I ./O
However/O ,/O five/O new/O mutation/O sites/O (/O S61/I ,/O SL1/I ,/O S29/I ,/O SL11/I ,/O SL196/I and/O SL126/I )/O are/O unique/O to/O the/O nrdB/I intron/O and/O disrupt/O self/O -/O splicing/O ./O
This/O report/O presents/O the/O isolation/O and/O characterization/O of/O the/O 5/O '-/O flanking/O region/O (/O 1/O ./O 2/O kb/O )/O and/O exon/O 1/O of/O the/O human/I RII/I alpha/I gene/I ./O
A/O cohort/O of/O Swedish/O children/O was/O monitored/O from/O 6/O months/O to/O 11/O years/O of/O age/O ./O
The/O aim/O of/O this/O study/O was/O to/O assess/O the/O reproducibility/O of/O a/O number/O of/O simplified/O clearance/O methods/O using/O chromium/O -/O 51/O ethylenediamine/O tetraacetic/O acid/O (/O 51Cr/O -/O EDTA/O )/O and/O to/O compare/O these/O with/O the/O multiple/O blood/O sample/O technique/O ./O
The/O primary/O structure/O of/O a/O 2671/O bp/O DNA/O fragment/O between/O the/O pla/I gene/I (/O encoding/O plasminogen/I activator/I )/O and/O the/O origin/O of/O replication/O of/O the/O wild/O -/O type/O Yersinia/O pestis/O plasmid/O pYP358/O was/O determined/O ./O
Serotonin/O concentration/O in/O the/O blood/O of/O patients/O with/O hemorrhagic/O fever/O with/O renal/O syndrome/O
MAIN/O OUTCOME/O MEASURES/O :/O Associations/O of/O factor/O analysis/O -/O derived/O syndromes/O with/O risk/O factors/O for/O chemical/O interactions/O that/O inhibit/O butyrylcholinesterase/I and/O neuropathy/O target/O esterase/I ./O
CONCLUSION/O :/O Some/O Gulf/O War/O veterans/O may/O have/O delayed/O ,/O chronic/O neurotoxic/O syndromes/O from/O wartime/O exposure/O to/O combinations/O of/O chemicals/O that/O inhibit/O butyrylcholinesterase/I and/O neuropathy/I target/I esterase/I ./O
Control/O examination/O was/O performed/O at/O the/O end/O of/O each/O period/O ./O
No/O correlation/O between/O the/O age/O of/O the/O horses/O and/O the/O antibody/O level/O could/O be/O found/O ./O
The/O GHR/I mRNA/I :/O GHBP/I mRNA/I ratio/O was/O 1/O ./O 1/O +/-/O 0/O ./O 12/O and/O remained/O unchanged/O during/O differentiation/O ./O
The/O results/O demonstrate/O (/O i/O )/O that/O the/O selenocysteine/O -/O specific/O UGA/O codon/O is/O readily/O suppressed/O under/O conditions/O where/O the/O homologous/I SelB/I protein/I is/O absent/O and/O (/O ii/O )/O that/O apart/O from/O the/O specificity/O of/O the/O SelB/I -/I mRNA/I interaction/O ,/O a/O structural/O compatibility/O of/O the/O quaternary/O complex/O with/O the/O ribosome/O is/O required/O ./O
One/O linker/O -/O peptide/O insertion/O in/O the/O RsaA/I C/I terminus/I (/I amino/I acid/I 784/I )/I had/O no/O effect/O on/O S/O -/O layer/O biogenesis/O ,/O while/O another/O (/O amino/O acid/O 907/O )/O disrupted/O secretion/O of/O the/O protein/O ,/O suggesting/O that/O RsaA/I possesses/O a/O secretion/O signal/O lying/O C/O terminal/O to/O amino/O acid/O 784/O ,/O near/O or/O including/O amino/O acid/O 907/O ./O
To/O characterize/O the/O gene/O products/O ,/O the/O cvaA/I gene/I was/O subcloned/O and/O expressed/O under/O the/O control/O of/O T7/I RNA/I polymerase/I promoter/I ./O
PrpB/I showed/O homology/O to/O carboxyphosphonoenolpyruvate/I phosphonomutase/I of/I Streptomyces/I hygroscopicus/I and/O to/O its/O homolog/O in/O the/O carnation/O Dianthus/O caryophyllus/O ;/O PrpC/I was/O homologous/O to/O both/O archaeal/I and/I bacterial/I citrate/I synthases/I ;/O PrpD/I showed/O homology/O to/O yeast/O and/O Bacillus/O subtilis/O proteins/O of/O unknown/O function/O ;/O PrpE/I showed/O homology/O to/O acetyl/I coenzyme/I A/I synthetases/I ./O
MAIN/O OUTCOME/O MEASURES/O :/O Systemic/O and/O pulmonary/O hemodynamics/O ,/O arterial/O blood/O gas/O determination/O ,/O bronchoalveolar/O lavage/O protein/O and/O neutrophil/O content/O ,/O neutrophil/O oxidant/O burst/O ,/O lung/I myeloperoxidase/I content/O ,/O and/O scanning/O electron/O micrographic/O studies/O ./O
We/O have/O isolated/O a/O cDNA/O encoding/O human/I MEKK3/I ./O
To/O investigate/O the/O mechanisms/O involved/O in/O the/O transcriptional/O control/O of/O retinoid/I X/I receptor/I (/O RXR/I )/O gene/O expression/O ,/O the/O 5/O '-/O flanking/O region/O of/O the/O human/I RXRgamma2/I isoform/I was/O characterized/O ./O
JNK/I and/O p38/I are/O constitutively/O present/O in/O the/O nucleus/O ,/O and/O DNA/O -/O bound/O c/I -/I JUN/I and/O ATF/I -/I 2/I are/O stably/O contacted/O by/O JNK/I and/O p38/I ,/O respectively/O ./O
The/O effects/O of/O dominant/O interfering/O forms/O of/O the/O JNK/I //O p38/I signaling/O pathway/O demonstrate/O that/O activation/O of/O these/O kinases/O is/O critical/O for/O cytokine/O -/O induced/O E/I -/I selectin/I gene/I expression/O ./O
Sp1/I binds/O the/O CTC/O repeat/O with/O an/O affinity/O ,/O KD/O =/O 0/O ./O 37/O nM/O ,/O at/O least/O as/O high/O as/O the/O consensus/O GC/O box/O ./O
Identification/O of/O the/O region/O in/O actin/I -/I binding/I protein/I that/O binds/O to/O the/O cytoplasmic/O domain/O of/O glycoprotein/I IBalpha/I ./O
Mutant/O enzyme/O forms/O were/O prepared/O to/O eliminate/O the/O initial/O autoprocessing/O site/O and/O thus/O form/O an/O active/O single/O -/O chain/O protein/O for/O structure/O -/O function/O studies/O ./O
The/O primer/O is/O generated/O by/O a/O cleavage/O that/O occurs/O between/O bases/O 11/O and/O 12/O of/O the/O Tf1/I mRNA/I ./O
Similarly/O ,/O we/O examined/O whether/O the/O ELK1/I ,/O SAP1a/I ,/O FLI1/I ,/O EWS/I -/O FLI1/I ,/O ETS1/I ,/O ETS2/I ,/O PEA3/I and/O PU/I ./I 1/I proteins/I can/O form/O ternary/O complexes/O with/O SRF/I on/O the/O Egr1/I SREI/I and/I II/I ./O
This/O R/O -/O domain/O may/O modulate/O the/O interaction/O with/O SRF/I ,/O providing/O a/O mechanism/O that/O would/O be/O unique/O to/O FLI1/I and/O EWS/I -/O FLI1/I ,/O thus/O implicating/O a/O novel/O function/O for/O these/O ETS/I transcription/I factors/I in/O the/O regulation/O of/O the/O Egr1/I gene/I ./O
The/O total/O number/O of/O specimens/O was/O 131/O with/O 78/O nonsmokers/O and/O 53/O smokers/O ./O
The/O murine/O chromosomal/O locations/O of/O the/O five/O NMDA/I receptor/I channel/I subunits/I ,/O the/O epsilon/I 1/I (/O Grin2a/I ),/O epsilon/I 2/I (/O Grin2b/I ),/O epsilon/I 3/I (/O Grin2c/I ),/O epsilon/I 4/I (/O Grin2d/I )/O and/O zeta/I 1/I (/O Grinl/I )/O subunits/O ,/O were/O determined/O using/O an/O interspecific/O backcross/O mapping/O panel/O derived/O from/O crosses/O of/O [(/O C57BL/O //O 6JxM/O ./O spretus/O )/O F1xC57BL/O //O 6J/O ]/O mice/O ./O
CDNA/O cloning/O of/O chick/I brain/I alpha/I -/I amino/I -/I 3/I -/I hydroxy/I -/I 5/I -/I methyl/I -/I 4/I -/I isoxazolepropionic/I acid/I receptors/I reveals/O conservation/O of/O structure/O ,/O function/O and/O post/O -/O transcriptional/O processes/O with/O mammalian/O receptors/O ./O
Remarkably/O ,/O both/O TTD/O -/O A/O and/O XP/O -/O D/O defects/O are/O associated/O with/O subunits/O of/O TFIIH/I ,/O a/O basal/O transcription/O factor/O with/O a/O second/O function/O in/O DNA/O repair/O ./O
Adjustment/O for/O age/O ,/O total/O cholesterol/O ,/O HDL/I cholesterol/I ,/O triglycerides/O ,/O current/O smoking/O ,/O and/O systolic/O pressure/O slightly/O reduced/O the/O association/O between/O fibrinogen/I and/O atherosclerosis/O ./O
In/O Experiment/O 1/O ,/O pups/O that/O had/O received/O an/O injection/O of/O the/O noncompetitive/O N/I -/I methyl/I -/I D/I -/I aspartate/I receptor/I antagonist/O MK/O -/O 801/O (/O 0/O ./O 1/O mg/O //O kg/O ,/O i/O ./O p/O .)/O either/O 30/O min/O before/O or/O immediately/O after/O conditioning/O spent/O less/O time/O over/O the/O conditioned/O odor/O than/O saline/O -/O treated/O controls/O ./O
Cholesterol/I side/I -/I chain/I cleavage/I cytochrome/I P450/I (/O CYP11A/I ;/O P450scc/I )/O gene/O expression/O is/O regulated/O by/O gonadotropins/I via/O cAMP/O in/O the/O ovary/O and/O by/O ACTH/I via/O cAMP/O in/O adrenal/O cortical/O cells/O ./O
One/O possible/O solution/O is/O a/O thin/O radial/O forearm/O free/O flap/O ./O
Structural/O analysis/O and/O characterization/O of/O tissue/O and/O hormonal/O responsive/O expression/O of/O the/O avian/I bone/I sialoprotein/I (/O BSP/I )/O gene/O ./O
Serotonin/I receptors/I in/O suicide/O victims/O with/O major/O depression/O ./O
The/O Y/O -/O type/O structural/O motif/O is/O also/O conserved/O among/O a/O number/O of/O divergent/O BiP/I mRNAs/I ./O
A/O false/O positive/O marker/O screen/O was/O associated/O with/O the/O occurrence/O of/O hand/O -/O foot/O syndrome/O even/O when/O the/O effect/O of/O regimen/O was/O accounted/O for/O by/O stratification/O (/O p/O =/O ./O 01/O )./O
The/O detection/O of/O ORF/I -/I 1/I sequences/O in/O human/O tumors/O ,/O while/O not/O proof/O per/O se/O ,/O is/O a/O prerequisite/O for/O establishing/O its/O role/O in/O tumor/O development/O ./O
Phylogenetic/O analysis/O gave/O evidence/O for/O a/O close/O evolutionary/O relationship/O between/O PhHV/O -/O 1/O and/O members/O of/O the/O Varicellovirus/O genus/O of/O the/O alpha/O -/O Herpesvirinae/O and/O canid/O herpesvirus/O in/O particular/O ./O
In/O this/O method/O ,/O PLP/O in/O plasma/O can/O be/O determined/O with/O high/O sensitivity/O using/O derivatization/O with/O sodium/O bisulfite/O in/O the/O mobile/O phase/O ./O
Both/O HEF1/I and/O Cas/I were/O found/O to/O complex/O with/O the/O related/I adhesion/I focal/I tyrosine/I kinase/I (/O RAFTK/I ),/O and/O when/O tyrosine/O phosphorylated/O ,/O with/O the/O adapter/O molecule/O CrkL/I ./O
SIM1/I and/O SIM2/I do/O not/O form/O homodimers/O ,/O and/O they/O do/O not/O interact/O with/O AHR/I ./O
Complexes/O of/O qTBP42/I with/O each/O complementary/O strand/O of/O telomeric/O DNA/O and/O with/O quadruplex/O forms/O of/O the/O guanine/O -/O rich/O strand/O had/O 3/O ./O 7/O -/O 14/O ./O 6/O nM/O dissociation/O constants/O ,/O Kd/O ,/O whereas/O complexes/O with/O double/O -/O stranded/O telomeric/O DNA/O had/O up/O to/O 100/O -/O fold/O higher/O Kd/O values/O ./O
Moreover/O ,/O the/O effect/O exerted/O by/O TIS1/I appeared/O to/O be/O selective/O for/O the/O MCK/I promoter/I ./O
Experimental/O data/O showed/O that/O these/O abnormal/O proteins/O are/O constitutively/O localized/O in/O the/O nucleus/O ,/O have/O lost/O the/O transcriptional/O repressor/O functions/O typical/O of/O normal/O NF/I -/I kappa/I B2p52/I and/O may/O be/O capable/O of/O transactivation/O activity/O ./O
Because/O L/I -/I plastin/I expression/O in/O tissue/O -/O specifically/O regulated/O in/O both/O humans/O and/O rodents/O ,/O it/O is/O likely/O that/O similar/O mechanisms/O regulate/O L/I -/I plastin/I gene/I expression/O in/O human/O and/O rodent/O cells/O and/O that/O they/O could/O be/O identified/O by/O comparing/O the/O function/O and/O nucleotide/O sequences/O of/O the/O human/O and/O murine/O L/I -/I plastin/I gene/O promoters/O ./O
What/O '/O s/O new/O in/O gynecologic/O and/O obstetrical/O surgery/O ./O
The/O dnaK/I operon/I of/I Bacillus/I subtilis/I is/O heptacistronic/O ./O
Moreover/O ,/O expression/O of/O CBF1/I in/O yeast/O was/O found/O to/O activate/O transcription/O of/O reporter/O genes/O containing/O the/O C/O -/O repeat/O //O DRE/O as/O an/O upstream/O activator/O sequence/O but/O not/O mutant/O versions/O of/O the/O DNA/O element/O ./O
Forty/O -/O one/O ASA/O physical/O status/O I/O or/O II/O adult/O patients/O undergoing/O a/O variety/O of/O 1/O -/O 1/O ./O 5/O h/O surgical/O procedures/O were/O randomly/O allocated/O to/O receive/O CCA/O with/O desflurane/O or/O isoflurane/O with/O ventilation/O being/O either/O spontaneous/O or/O controlled/O ./O
OBJECTIVE/O :/O Our/O goal/O was/O to/O determine/O whether/O chlamydia/O -/O infected/O women/O have/O a/O higher/O rate/O of/O febrile/O complications/O after/O postpartum/O tubal/O ligation/O ./O
In/O the/O electrophoresis/O mobility/O shift/O assay/O using/O nuclear/O extracts/O of/O the/O myogenic/O cells/O ,/O MyoD/I and/O myogenin/I bound/O to/O the/O right/O E/O -/O box/O in/O the/O enhancer/O region/O of/O the/O MCK/I gene/I even/O in/O the/O presence/O of/O BMP/I -/I 2/I ./O
A/O heterologous/O promoter/O construct/O containing/O three/O repeats/O of/O a/O consensus/O Sp1/I site/I ,/O cloned/O upstream/O of/O a/O single/O copy/O of/O the/O ZII/I (/O CREB/I //I AP1/I )/O element/O from/O the/O BZLF1/I promoter/I linked/O to/O the/O beta/I -/I globin/I TATA/O box/O ,/O exhibited/O phorbol/O ester/O inducibility/O ./O
Subsequent/O experiments/O showed/O that/O motoric/O tasks/O rather/O than/O cognitive/O aspects/O of/O the/O COWA/O task/O were/O critical/O in/O potentiating/O finger/O -/O tapping/O performance/O ./O
How/O does/O a/O nurse/O go/O about/O maintaining/O her/O level/O of/O competence/O when/O she/O is/O one/O of/O the/O few/O local/O practitioners/O in/O her/O field/O ?/O Vancouver/O sex/O therapist/O Bianca/O Rucker/O is/O doing/O it/O by/O cultivating/O a/O network/O of/O colleagues/O and/O mentors/O in/O related/O fields/O both/O at/O home/O and/O across/O the/O continent/O ./O
Finally/O ,/O antibody/O binding/O to/O site/O IIIa/O on/O the/O hCG/I -/I ectodomain/I complex/I was/O also/O hindered/O by/O an/O anti/O -/O peptide/O mAb/O directed/O against/O a/O peptide/O encoded/O by/O the/O eighth/O exon/O (/O pE/O x/O 8/O )/O of/O the/O LHR/I ./O
cDNA/O cloning/O ,/O expression/O analysis/O ,/O and/O chromosomal/O localization/O of/O a/O gene/O with/O high/O homology/O to/O wheat/I eIF/I -(/I iso/I )/I 4F/I and/O mammalian/I eIF/I -/I 4G/I ./O
Therefore/O ,/O it/O is/O important/O to/O control/O hypertension/O and/O keep/O appropriate/O renal/O blood/O flow/O during/O living/O renal/O transplantation/O surgery/O ./O
The/O initial/O patients/O treated/O with/O AZQ/O and/O mitroxantrone/O experienced/O prolonged/O bone/O marrow/O suppression/O and/O ,/O therefore/O ,/O subsequent/O cohorts/O were/O treated/O with/O G/I -/I CSF/I ,/O 5/O micrograms/O //O kg/O ,/O beginning/O the/O day/O after/O completion/O of/O the/O third/O cycle/O of/O chemotherapy/O ./O
Human/I granulocyte/I -/I macrophage/I colony/I -/I stimulating/I factor/I (/O hGM/I -/I CSF/I )/O activates/O a/O set/O of/O genes/O such/O as/O c/I -/I fos/I ,/O jun/I ,/O myc/I ,/O and/O early/I growth/I response/I gene/I 1/I (/O egr/I -/I 1/I )./O
In/O order/O to/O provide/O adequate/O local/O control/O without/O compromising/O cosmetic/O outcome/O ,/O the/O amount/O of/O breast/O tissue/O that/O must/O be/O excised/O in/O BCT/O needs/O to/O be/O individualized/O ./O
Surprisingly/O ,/O however/O ,/O TCR/I -/O mediated/O tyrosine/O phosphorylation/O of/O phospholipase/I C/I gamma/I 1/I remains/O intact/O in/O the/O Jurkat/O cells/O expressing/O the/O A2/I //O HCP/I chimera/O ./O
The/O 14/I ./I 1/I (/I IGLL1/I )/I gene/I is/O expressed/O in/O a/O lineage/O -/O and/O stage/O -/O restricted/O manner/O ./O
The/O interferon/I (/O IFN/I )-/O induced/O double/I -/I stranded/I RNA/I (/I dsRNA/I )-/I activated/I Ser/I //I Thr/I protein/I kinase/I (/O PKR/I )/O plays/O a/O role/O in/O the/O antiviral/O and/O antiproliferative/O effects/O of/O IFN/I ./O
Together/O ,/O the/O data/O suggest/O that/O cAMP/O -/O dependent/O control/O of/O the/O amounts/O of/O the/O activator/O SF/I -/I 1/I vs/O ./O the/O repressor/O COUP/I -/I TF/I could/O influence/O CRS2/O -/O dependent/O transcription/O ./O
Object/O relations/O ,/O affect/O management/O ,/O and/O psychic/O structure/O formation/O ./O
When/O expressed/O in/O COS/O -/O 7/O cells/O ,/O MKP/I -/I 4/I blocks/O activation/O of/O MAP/I kinases/I with/O the/O selectivity/O ERK/I >/O p38/I =/O JNK/I //O SAPK/I ./O
In/O rlf2/I mutants/I ,/O telomeric/O chromatin/O is/O perturbed/O :/O Telomeric/O silencing/O is/O reduced/O and/O Rap1p/I localization/O is/O altered/O ./O
Most/O kinases/O are/O not/O significantly/O inhibited/O by/O roscovitine/O ./O cdc2/I //O cyclin/I B/I ,/O cdk2/I //O cyclin/I A/I ,/O cdk2/I //O cyclin/I E/I and/O cdk5/I //O p35/I only/O are/O substantially/O inhibited/O (/O IC50/O values/O of/O 0/O ./O 65/O ,/O 0/O ./O 7/O ,/O 0/O ./O 7/O and/O 0/O ./O 2/O microM/O ,/O respectively/O )./O cdk4/I //O cyclin/I D1/I and/O cdk6/I //O cyclin/I D2/I are/O very/O poorly/O inhibited/O by/O roscovitine/O (/O IC50/O >/O 100/O microM/O )./O
This/O 0/O ./O 74/O kb/O cDNA/O contains/O an/O open/O reading/O frame/O (/O ORF/O )/O of/O 477/O bp/O encoding/O a/O polypeptide/O of/O 159/O amino/O acids/O (/O aa/O )/O which/O differs/O at/O only/O one/O position/O (/O position/O 65/O )/O from/O the/O human/I U1/I -/I C/I protein/I ./O
Interaction/O of/O Ets/I -/I 1/I and/O the/O POU/I -/I homeodomain/I protein/I GHF/I -/I 1/I //O Pit/I -/I 1/I reconstitutes/O pituitary/O -/O specific/O gene/O expression/O ./O
Although/O Pho85/I is/O not/O essential/O for/O viability/O ,/O Pcl1/I ,/I 2/I -/O Pho85/I kinase/O complexes/O become/O essential/O for/O Start/O in/O the/O absence/O of/O Cln1/I ,/I 2/I -/O Cdc28/I kinases/O ./O
Using/O the/O yeast/O two/O -/O hybrid/O system/O to/O screen/O for/O proteins/O which/O interact/O with/O Tax1/I ,/O we/O isolated/O the/O B/O subunit/O of/O the/O CCAAT/O binding/O protein/O NF/I -/I Y/I from/O a/O HeLa/O cDNA/O library/O ./O
Enhancer/O activity/O requires/O both/O the/O AP/I -/I 1/I site/I and/O these/O adjacent/O sequences/O ./O
Studies/O using/O HLA/I -/I DR/I -/O B7/I -/I 1/I -/O LFA/I -/I 3/I triple/O transfectants/O showed/O that/O the/O LFA/I -/I 3/I -/O induced/O NF/I -/I AT/I DNA/O binding/O activity/O was/O negatively/O regulated/O by/O B7/I -/I 1/I costimulation/O ./O
Constitutive/O activation/O of/O Rac1/I and/O RhoA/I causes/O tumorigenic/O transformation/O of/O NIH/O 3T3/O cells/O ,/O and/O their/O functions/O may/O be/O required/O for/O full/O Ras/I transformation/O ./O
Furthermore/O ,/O Rac1/I activation/O of/O JNK/I or/O SRF/I ,/O or/O induction/O of/O lamellipodia/O ,/O was/O neither/O necessary/O nor/O sufficient/O for/O Rac1/I transforming/O activity/O ./O
Overexpression/O of/O the/O bZip/O interaction/O domain/O of/O CBP/I specifically/O abolishes/O the/O positive/O cross/O talk/O between/O TR/I and/O p45/I //O NF/I -/I E2/I ./O
This/O inhibitory/O domain/O has/O been/O deleted/O in/O all/O naturally/O occurring/O AHC/I deletion/I mutants/I described/O to/O date/O ./O
Identification/O of/O a/O promoter/O -/O specific/O transactivation/O domain/O in/O the/O herpes/I simplex/I virus/I regulatory/I protein/I ICP4/I ./O
DNA/O sequencing/O of/O a/O 17/O -/O kb/O segment/O encompassing/O a/O gammaherpesvirus/O divergent/O locus/O (/O DL/O -/O B/O )/O between/O ORF11/O and/O ORF17/O revealed/O the/O presence/O of/O nine/O viral/O ORFs/O with/O predicted/O gene/O products/O related/O to/O cellular/O proteins/O ./O
Studies/O in/O mammalian/O cells/O have/O correlated/O induction/O of/O inhibitory/O tyrosine/O 15/O (/O Y15/O )/O phosphorylation/O on/O p34cdc2/I with/O the/O response/O to/O DNA/O damage/O ./O
We/O report/O herein/O the/O case/O of/O a/O 30/O -/O year/O -/O old/O man/O in/O whom/O ectopic/O mediastinal/O parathyroid/O adenoma/O was/O detected/O by/O 99mTc/O -/O methoxyisobutylisonitrile/O scintigraphy/O (/O 99mTc/O -/O MIBI/O )./O
Cardiac/I endothelin/I release/O and/O infarct/O size/O ,/O myocardial/O blood/O flow/O ,/O and/O ventricular/O function/O in/O canine/O infarction/O and/O reperfusion/O ./O
The/O workup/O included/O skin/O tests/O (/O up/O to/O 1/O microgram/O //O ml/O ,/O Pharmacia/O ),/O measurement/O of/O specific/O serum/O IgE/I with/O RAST/O -/O CAP/O (/O Pharmacia/O ),/O and/O CAST/O with/O three/O concentrations/O of/O bee/O (/O Apis/O mellifera/O )/O and/O wasp/O (/O Vespula/O spec/O .)/O venom/O (/O Aquagen/O ALK/O )./O
The/O proliferation/I potential/I protein/I -/I related/I (/O P2P/I -/I R/I )/O gene/O with/O domains/O encoding/O heterogeneous/O nuclear/O ribonucleoprotein/O association/O and/O Rb1/I binding/O shows/O repressed/O expression/O during/O terminal/O differentiation/O ./O
Recent/O application/O of/O recombinant/O canarypox/O ALVAC/O //O HIV/O -/O 1/O vectors/O as/O vaccine/O immunogens/O in/O HIV/O -/O 1/O ,-/O noninfected/O volunteers/O has/O produced/O CTL/O responses/O in/O a/O significant/O number/O of/O vaccinees/O ./O
The/O relevance/O of/O these/O elements/O in/O conferring/O anaerobic/O induction/O of/O gpc4/I gene/I expression/O is/O discussed/O ./O
Exons/O A1a/O and/O A1b/O are/O separated/O from/O each/O other/O by/O a/O 124/O -/O nucleotide/O intron/O ./O
A/O MEK/I -/O specific/O inhibitor/O (/O PD098059/O )/O (/O Dudley/O ,/O D/O ./O
These/O data/O support/O the/O idea/O that/O the/O repression/O activity/O of/O NRSF/I //O REST/I depends/O upon/O the/O species/O of/O promoter/O to/O which/O it/O is/O linked/O and/O upon/O the/O proteins/O that/O bind/O to/O those/O promoters/O ./O
Enhanced/O period/O -/O peak/O analysis/O of/O electro/O -/O encephalograms/O using/O a/O fast/O sinc/O function/O ./O
In/O summary/O ,/O p56/I (/O lck/I )/O activity/O stimulates/O G1/O //O S/O transition/O in/O immature/O thymoblasts/O and/O maintains/O cell/O viability/O via/O transduction/O of/O constitutive/O activation/O signals/O downstream/O to/O components/O of/O the/O Ras/I //O Raf/I //O MAPK/I pathway/O ./O
However/O ,/O the/O action/O of/O each/O cognate/O ligand/O and/O the/O accessory/O cellular/O factors/O that/O can/O differentially/O regulate/O the/O transcriptional/O responses/O of/O a/O heterodimer/O -/O DNA/O complex/O are/O not/O well/O understood/O ./O
We/O have/O measured/O the/O MBF/O on/O incisors/O and/O its/O direction/O in/O three/O dimensions/O for/O different/O jaw/O openings/O in/O ten/O subjects/O ./O
These/O findings/O suggest/O that/O intraarterial/O neoadjuvant/O chemotherapy/O should/O be/O effective/O on/O advanced/O cervical/O cancer/O ./O
The/O FBF/O questionnaire/O did/O not/O highlight/O a/O characteristic/O basic/O symptoms/O profile/O of/O schizoaffective/O disorder/O ,/O when/O compared/O with/O bipolar/O affective/O disorder/O and/O schizophrenia/O ./O
The/O alternative/O sigma/I factor/I sigmaB/I in/I Staphylococcus/I aureus/I :/O regulation/O of/O the/O sigB/I operon/I in/O response/O to/O growth/O phase/O and/O heat/O shock/O
Cognate/O promoter/O elements/O implicated/O in/O glucocorticoid/O -/O and/O cAMP/O -/O mediated/O regulation/O as/O well/O as/O in/O liver/O -,/O myeloid/O -,/O and/O lymphocyte/O -/O specific/O expression/O are/O located/O within/O the/O 5/O '/O flanking/O sequence/O ./O
Clinically/O meaningful/O decreases/O due/O to/O alkalinization/O alone/O within/O 30/O minutes/O are/O unlikely/O ./O
We/O have/O studied/O the/O biokinetics/O of/O BLM/O labeled/O with/O indium/O -/O 111/O (/O In/O -/O 111/O )./O
CD3/I cross/O -/O linking/O induced/O tyrosine/O phosphorylation/O of/O Sam68/I in/O uninfected/O T/O cells/O ./O
Acetoin/O -/O dependent/O expression/O of/O the/O acoABCD/I operon/I could/O be/O restored/O in/O the/O E/I ./I coli/I acoK/I mutants/I by/O supplying/O a/O plasmid/O carrying/O an/O intact/O acoK/I ,/O suggesting/O a/O transactivating/O function/O of/O the/O gene/O product/O ./O
Mutations/O in/O the/O alpha/I and/I sigma/I -/I 70/I subunits/I of/I RNA/I polymerase/I affect/O expression/O of/O the/O mer/I operon/I ./O
Taken/O together/O ,/O we/O provide/O evidence/O for/O the/O existence/O of/O an/O activator/O ,/O NFE/I ,/O which/O in/O combination/O with/O the/O p50/I and/O c/I -/I Rel/I proteins/I ,/O are/O part/O of/O the/O transcription/O factor/O machinery/O that/O regulates/O 3/O '/O enhancer/O activity/O ,/O and/O thus/O the/O control/O of/O the/O IgH/I locus/I in/O late/O B/O lymphocyte/O development/O ./O
The/O neuroprotective/O efficacy/O of/O the/O selective/O N/O -/O type/O voltage/O -/O sensitive/O calcium/O channel/O blocker/O ,/O SNX/O -/O 111/O ,/O was/O evaluated/O in/O spontaneously/O hypertensive/O rats/O subjected/O to/O 60/O min/O of/O focal/O cerebral/O ischemia/O by/O permanent/O ligation/O of/O the/O right/O common/O carotid/O artery/O and/O temporary/O occlusion/O of/O the/O right/O middle/O cerebral/O artery/O ./O
The/O genes/O encoding/O the/O transcription/I factor/I yTAFII60/I ,/O the/O G4p1/I protein/I and/O a/O putative/O glucose/O transporter/O are/O contained/O in/O a/O 12/O ./O 3/O kb/O DNA/O fragment/O on/O the/O left/O arm/O of/O Saccharomyces/O cerevisiae/O chromosome/O VII/O ./O
The/O protector/O doubled/O the/O estimated/O fall/O distance/O for/O fracture/O of/O the/O trochanter/O ./O
Marinol/O //O marijuana/O usage/O was/O associated/O with/O depressed/O CD4/I +/I counts/O and/O elevated/O amylase/I levels/O within/O the/O DDI/O subgroup/O ./O
METHODS/O :/O Fifty/O -/O eight/O patients/O who/O underwent/O a/O curative/O hepatic/O resection/O for/O HCC/O and/O whose/O preoperative/O AFP/I levels/O were/O >/O 100/O ng/O //O ml/O ,/O were/O selected/O for/O this/O study/O ./O
Calmodulin/I -/I binding/I peptide/I (/O CBP/I ),/O a/O peptide/O of/O 26/O amino/O acids/O derived/O from/O muscle/I myosin/I light/I chain/I kinase/I (/O MLCK/I ),/O binds/O to/O calmodulin/I with/O nanomolar/O affinity/O ./O
Here/O we/O show/O that/O the/O type/O of/O tyrosine/I kinase/I receptor/I stimulated/O also/O participates/O in/O the/O nature/O of/O the/O cAMP/O effect/O ./O
To/O gain/O insight/O into/O the/O possible/O involvement/O of/O p21/I in/O liver/O cell/O growth/O ,/O the/O expression/O and/O regulation/O of/O the/O p21/I gene/I was/O evaluated/O in/O rodent/O models/O of/O liver/O regeneration/O and/O specimens/O of/O human/O liver/O diseases/O ./O
Northern/O blot/O analysis/O of/O LeMT/I (/I A/I )/I and/O LeMT/I (/I B/I )/I showed/O that/O transcripts/O of/O both/O MT/I -/I like/I genes/I were/O more/O abundant/O in/O leaves/O than/O roots/O in/O tomato/O plants/O grown/O without/O addition/O of/O extra/O metal/O ions/O ,/O a/O characteristic/O of/O type/I II/I MTs/I ./O
In/O co/O -/O transfection/O studies/O ,/O an/O AP/I -/I 2/I but/O not/O an/O Egr/I -/I 1/I expression/O vector/O activated/O VPF/I //O VEGF/I transcription/O ,/O thus/O indicating/O that/O AP/I -/I 2/I protein/I is/O functionally/O important/O in/O TGF/I alpha/I -/O induced/O VPF/I //O VEGF/I gene/O expression/O ./O
The/O HBP/I gene/I is/O composed/O of/O eight/O exons/O covering/O 19/O ./O 5/O kb/O on/O the/O short/O arm/O of/O chromosome/O 4/O ./O
In/O some/O instances/O ,/O this/O is/O partly/O mediated/O by/O the/O expression/O of/O virally/O encoded/O proteases/O which/O lead/O to/O the/O cleavage/O of/O initiation/I factor/I eIF4G/I ./O
The/O best/O endometrial/O ablation/O was/O seen/O when/O SnET2/O was/O given/O by/O intrauterine/O administration/O with/O light/O treatment/O at/O 150/O J/O //O cm/O 24/O hours/O later/O ./O
Unlike/O class/O II/O -/O and/O III/O -/O specific/O TBP/I -/O TAF/I complexes/O ,/O the/O corresponding/O murine/O and/O human/O class/O I/O -/O specific/O transcription/O initiation/O factor/O TIF/I -/I IB/I //O SL1/I exhibits/O a/O pronounced/O selectivity/O for/O its/O homologous/O promoter/O ./O
Cytohesin/I -/I 1/I ,/O a/O protein/O abundant/O in/O cells/O of/O the/O immune/O system/O ,/O has/O been/O proposed/O to/O be/O a/O human/O homolog/O of/O the/O Saccharomyces/I cerevisiae/I Sec7/I gene/I product/I ,/O which/O is/O crucial/O in/O protein/O transport/O ./O
In/O this/O regard/O ,/O it/O differs/O from/O a/O recently/O reported/O BFA/O -/O sensitive/O ARF/I -/O GEP/I that/O contains/O a/O Sec7/I domain/I ./O
We/O now/O describe/O the/O identification/O of/O DEK/I as/O this/O 43/I -/I kDa/I pets/I factor/I ./O
These/O elements/O comprise/O a/O binding/O site/O for/O Krox/I proteins/I ,/O one/O for/O nuclear/I factor/I 1/I ,/O an/O octamer/O motif/O that/O binds/O POU/I -/I homeodomain/I proteins/I ,/O and/O a/O novel/O TN/I control/I element/I ./O
Tissue/O samples/O were/O obtained/O either/O from/O rats/O that/O had/O been/O exposed/O to/O opiate/O withdrawal/O following/O a/O seven/O day/O morphine/O infusion/O or/O sham/O treated/O control/O subjects/O ./O
Therefore/O ,/O the/O impaired/O floor/O plate/O development/O in/O oep/I mutants/I is/O not/O caused/O by/O the/O absence/O of/O the/O floor/I plate/I inducer/I shh/I ./O
RESULTS/O :/O The/O medians/O of/O average/O daily/O CD34/I +/I cell/O yields/O for/O patients/O who/O received/O paclitaxel/O plus/O CY/O ,/O CE/O ,/O and/O CEP/O with/O G/I -/I CSF/I were/O 12/O ./O 9/O ,/O 11/O ./O 03/O ,/O and/O 5/O ./O 37/O x/O 10/O (/O 6/O )//O kg/O ,/O respectively/O ,/O compared/O with/O 2/O ./O 02/O x/O 10/O (/O 6/O )//O kg/O in/O the/O reference/O group/O that/O received/O CY/O with/O G/I -/I CSF/I (/O P/O =/O /I Ser/I )/I inhibited/O activity/O of/O MEK/I by/O approximately/O 25/O %,/O whereas/O expression/O of/O SHP/I -/I 1/I resulted/O in/O a/O approximately/O 25/O %/O increase/O ./O
This/O interaction/O involved/O the/O SH3/I region/I of/O p50/I (/O csk/I )/O and/O a/O proline/O -/O rich/O region/O (/O PPPLPERTPESFVLADM/O )/O outside/O the/O catalytic/O region/O of/O PTP/I -/O PEST/O ./O
Following/O 2/O ./O 5/O Gy/O ,/O HbO2/I changes/O were/O minimal/O ./O
Polarised/O expression/O of/O human/O intestinal/O N/I -/I benzoyl/I -/I L/I -/I tyrosyl/I -/I p/I -/I aminobenzoic/I acid/I hydrolase/I (/O human/I meprin/I )/O alpha/O and/O beta/O subunits/O in/O Madin/O -/O Darby/O canine/O kidney/O cells/O ./O
Neither/O mutant/O exhibited/O derepression/O of/O the/O silent/I mating/I type/I loci/I ./O
Among/O 38/O patients/O with/O inducible/O reentrant/O VTs/O who/O underwent/O electrophysiologic/O study/O (/O EPS/O ),/O 10/O VTs/O of/O six/O patients/O were/O selected/O ./O
The/O cycle/O length/O of/O induced/O VT/O (/O n/O =/O 10/O VTs/O )/O was/O 380/O +/-/O 41/O msec/O ./O
Transient/O hyperammonaemia/O in/O an/O adult/O German/O shepherd/O dog/O ./O
We/O established/O that/O the/O 2/O ./O 6/O kb/O mRNA/O V/O -/O 1/O and/O the/O 2/O ./O 3/O kb/O GGT/I mRNA/O V/O -/O 2/O derive/O ,/O by/O alternate/O splicing/O ,/O from/O a/O primary/O transcript/O initiated/O on/O a/O distal/O promoter/O on/O the/O rat/I GGT/I gene/I ./O
A/O specific/O distal/O promoter/O controls/O gamma/I -/I glutamyl/I transpeptidase/I gene/I expression/O in/O undifferentiated/O rat/O transformed/O liver/O cells/O ./O
These/O repressor/O sites/O are/O pyrimidine/O rich/O and/O bind/O avidly/O to/O the/O polypyrimidine/I tract/I binding/I protein/I (/O PTB/I )/O in/O HeLa/O nuclear/O extracts/O as/O determined/O by/O UV/O crosslinking/O //O competition/O assays/O ./O
For/O higher/O expression/O of/O lipA/I in/O S/O ./O lividans/O ,/O the/O gene/O was/O cloned/O next/O to/O the/O strong/O aphII/I promoter/I ./O
Within/O a/O 135/O -/O bp/O core/O homology/O region/O ,/O the/O human/I HS12/I enhancers/I are/O approximately/O 90/O %/O identical/O to/O the/O murine/O homolog/O and/O include/O several/O motifs/O previously/O demonstrated/O to/O be/O important/O for/O function/O of/O the/O murine/O enhancer/O ;/O additional/O segments/O of/O high/O sequence/O conservation/O suggest/O the/O possibility/O of/O previously/O unrecognized/O functional/O motifs/O ./O
In/O contrast/O to/O the/O wild/O -/O type/O protein/O ,/O expression/O of/O p45/I NF/I -/I E2/I lacking/O this/O activation/O domain/O in/O an/O NF/I -/I E2/I null/O cell/O line/O fails/O to/O support/O enhancer/O -/O dependent/O transcription/O in/O transient/O assays/O ./O
These/O findings/O suggest/O one/O potential/O mechanism/O for/O direct/O recruitment/O of/O distal/O regulatory/O regions/O of/O the/O globin/I loci/I to/O the/O individual/O promoters/O ./O
The/O promoter/O region/O showed/O no/O consensus/O TATA/O box/O but/O it/O contains/O CCAAT/O and/O CreA/I boxes/O known/O to/O be/O involved/O in/O both/O stress/O and/O carbon/O -/O catabolite/O regulation/O of/O fungal/O promoters/O ./O
The/O two/O cysteine/O residues/O located/O in/O this/O additional/O region/O may/O be/O involved/O in/O the/O formation/O of/O a/O disulfide/O bridge/O associated/O with/O the/O activation/O process/O of/O the/O catalytic/O activity/O ./O
The/O por/I gene/I has/O been/O expressed/O ,/O for/O the/O first/O time/O ,/O in/O anaerobically/O grown/O Escherichia/O coli/O behind/O the/O isopropyl/O -/O beta/O -/O D/O -/O thiogalactopyranoside/O -/O inducible/O tac/I promoter/I ,/O resulting/O in/O the/O production/O of/O POR/I in/O its/O active/O form/O ./O
When/O the/O downstream/O operator/O was/O altered/O ,/O there/O was/O a/O fourfold/O reduction/O in/O reporter/O enzyme/O levels/O ./O
The/O ORF3/O mutant/O produced/O reduced/O levels/O of/O tabtoxin/I ,/O indicating/O that/O ORF3/O may/O have/O a/O role/O in/O T/I beta/I L/I biosynthesis/O ./O
Refined/O Cox/O models/O using/O a/O CD4/I count/O of/O 150/O //O microL/O rather/O than/O 200/O //O microL/O to/O distinguish/O I0/O and/O I1/O yielded/O a/O simplified/O model/O with/O better/O fit/O to/O the/O observed/O data/O ./O
However/O ,/O the/O published/O reports/O consist/O of/O a/O small/O number/O of/O patients/O and/O limited/O data/O ./O
These/O transcripts/O contain/O the/O 5/O '/O ends/O of/O mature/O UbCRBP/I mRNAs/I ;/O extend/O through/O UbCRBP/I ,/O across/O the/O intergenic/O region/O ,/O and/O a/O significant/O distance/O 3/O '/O into/O the/O enolase/I gene/I ./O
The/O distribution/O of/O cryptosporidia/O in/O the/O intestine/O and/O number/O of/O cryptosporidia/O per/O ileal/O villus/O on/O different/O DPI/O were/O also/O estimated/O for/O detailed/O characterization/O of/O the/O infection/O in/O kids/O as/O a/O model/O for/O experimental/O cryptosporidiosis/O ./O
As/O a/O result/O ,/O the/O subendocardial/O //O subepicardial/O blood/O flow/O ratio/O (/O ENDO/O //O EPI/O )/O increased/O from/O 0/O ./O 44/O +/-/O 0/O ./O 09/O during/O control/O stenosis/O to/O 0/O ./O 85/O +/-/O 0/O ./O 13/O after/O ITF/O 1129/O (/O 10/O micrograms/O //O kg/O //O min/O i/O ./O v/O .)/O and/O to/O 0/O ./O 81/O +/-/O 0/O ./O 12/O after/O NTG/O ./O
Proteasomes/O are/O the/O multisubunit/O protease/O involved/O in/O the/O generation/O of/O peptides/O presented/O by/O MHC/I class/I I/I molecules/I ./O
In/O support/O of/O this/O interpretation/O we/O demonstrate/O that/O MQ9b/I binds/O strongly/O 5/O of/O 17/O motif/O -/O positive/O ,/O pathogen/O -/O derived/O synthetic/O peptides/O ./O
Takahashi/O ,/O H/O ./O
For/O sputum/I interleukin/I -/I 8/I there/O was/O an/O estimated/O true/O treatment/O median/O difference/O of/O 142/O pg/O //O ml/O (/O 95/O %/O confidence/O interval/O (/O CI/O )/O 8/O to/O 2866/O pg/O //O ml/O )/O in/O favour/O of/O placebo/O ;/O while/O for/O maximal/O expiratory/O flow/O at/O 25/O %/O (/O MEF25/O %)/O remaining/O forced/O vital/O capacity/O predicted/O for/O sex/O and/O height/O there/O was/O a/O 15/O percentage/O points/O (/O pp/O )/O (/O 95/O %/O CI/O 4/O to/O 26/O pp/O )/O mean/O treatment/O difference/O in/O favour/O of/O placebo/O ./O
However/O ,/O although/O deletion/O of/O Fp1/I in/O the/O hCRBP1/I gene/I yielded/O increased/O CAT/I activity/O ,/O pointing/O toward/O a/O negative/O regulatory/O function/O exerted/O by/O this/O element/O ,/O its/O insertion/O upstream/O of/O the/O p12/I basal/I promoter/I results/O in/O an/O impressive/O positive/O stimulation/O of/O CAT/I gene/I expression/O ./O
Gaucher/O '/O s/O disease/O is/O a/O rare/O metabolic/O disorder/O characterized/O by/O the/O lack/O of/O beta/I -/I glucocerebrosidase/I enzyme/I ./O
These/O discoloration/O '/O s/O can/O be/O treated/O in/O several/O ways/O but/O up/O to/O lately/O tooth/O structure/O had/O to/O be/O removed/O in/O an/O irreversible/O manner/O in/O order/O to/O provide/O sufficient/O bulk/O for/O the/O new/O restorative/O material/O ./O
The/O 9/O ;/O 22/O chromosomal/O translocation/O characteristic/O of/O CML/O results/O in/O a/O fused/O bcr/I //O abl/I gene/O and/O an/O abnormal/O fusion/O protein/O ,/O p210bcr/I //O abl/I ./O
Overexpression/O of/O BAG/I -/I 1/I also/O protected/O certain/O cell/O lines/O from/O heat/O shock/O -/O induced/O cell/O death/O ./O
The/O 5/O '/O flanking/O region/O contains/O potential/O binding/O sites/O for/O TATA/I -/I binding/I protein/I ,/O Sp1/I ,/O nuclear/I factor/I 1/I (/O NF1/I ),/O CAAT/I -/I box/I binding/I protein/I (/O C/I //I EBP/I ),/O hepatocyte/I nuclear/I factors/I 1/I and/I 5/I (/O HNF1/I ,/O HNF5/I )/O and/O activator/I proteins/I 1/I and/I 2/I (/O AP1/I ,/O AP2/I )./O
The/O recognition/O specificity/O of/O the/O p55/I PDZ/I domain/I appears/O to/O be/O unique/O ,/O since/O the/O three/O PDZ/I domains/I of/O hDlg/I (/O human/O lymphocyte/O homologue/O of/O the/O Drosophila/I discs/I large/I tumor/I suppressor/I )/O do/O not/O bind/O the/O cytoplasmic/O domain/O of/O glycophorin/I C/I ./O
By/O analyzing/O the/O RanGAP/I activity/O of/O a/O series/O of/O recombinantly/O expressed/O rna1p/I mutant/I derivatives/O ,/O we/O show/O that/O the/O highly/O acidic/O sequence/O in/O the/O C/O -/O terminal/O domain/O of/O both/O yeast/O proteins/O is/O indispensable/O for/O activating/O Ran/I -/O mediated/O GTP/O hydrolysis/O ./O
In/O the/O absence/O of/O MHC/I class/I II/I ,/O purified/I soluble/I D10/I TCR/I bound/O to/O Staphylococcus/I aureus/I enterotoxin/I C2/I with/O an/O association/O rate/O of/O 1/O ./O 69/O +/-/O 0/O ./O 12/O x/O 10/O (/O 4/O )/O M/O (-/O 1/O )/O sec/O (-/O 1/O )/O and/O a/O dissociation/O rate/O of/O 1/O ./O 9/O +/-/O 0/O ./O 47/O x/O 10/O (-/O 2/O )/O sec/O (-/O 1/O ),/O giving/O a/O dissociation/O constant/O of/O 1/O ./O 1/O microM/O ./O
Evidence/O for/O such/O peak/O shifts/O has/O been/O found/O in/O the/O responses/O of/O auditory/O nerve/O fibers/O ,/O cochlear/O microphonics/O ,/O and/O the/O responses/O of/O outer/O hair/O cells/O and/O supporting/O cells/O in/O the/O cochlea/O ,/O as/O well/O as/O in/O basilar/O membrane/O vibration/O measurements/O ,/O and/O indirectly/O ,/O in/O psychophysical/O data/O ./O
Mnt/I :/O Max/I complexes/O also/O efficiently/O suppress/O Myc/I -/O dependent/O activation/O from/O the/O same/O promoter/O ./O
In/O the/O United/O States/O high/O -/O MW/O HES/O 480/O which/O is/O difficult/O to/O degrade/O is/O most/O frequently/O used/O and/O results/O in/O a/O larger/O in/O vivo/O MW/O and/O subsequent/O decrease/O in/O factor/I VIII/I //O von/I Willebrand/I factor/I levels/O ./O
Assays/O of/O total/O cholesterol/O as/O well/O as/O the/O HDL/I ,/O HDL2/I ,/O LDL/I ,/O triglycerides/O ,/O endothelin/I -/I 1/I ,/O lipoprotein/O (/O a/O ),/O estradiol/O and/O FSH/I were/O also/O obtained/O at/O baseline/O before/O receiving/O ERT/O and/O after/O 3/O months/O of/O ERT/O ./O
Six/O tandem/O repeats/O of/O the/O P/I element/I linked/O to/O the/O SV40/I promoter/I responded/O to/O phorbol/O 12/O -/O myristate/O 13/O -/O acetate/O ,/O while/O that/O of/O other/O elements/O did/O not/O ./O
The/O distributed/O current/O density/O J/O is/O calculated/O within/O the/O volume/O defined/O by/O the/O motor/O unit/O ./O
The/O cleavage/O dipeptides/O of/O C1YVV/I NIa/I protease/I are/O Q/O (/O E/O )//O S/O (/O A/O ,/O G/O )./O
In/O our/O previous/O studies/O ,/O transcriptional/O activation/O was/O shown/O to/O correlate/O with/O IEP86/I binding/O to/O both/O the/O TATA/I -/I box/I binding/I protein/I (/O TBP/I )/O and/O the/O transcription/O factor/O bound/O upstream/O ./O
However/O ,/O we/O were/O unable/O to/O identify/O a/O p4/I molecule/O ./O
(/O iv/O )/O The/O accumulation/O of/O cyclin/I D3/I protein/I in/O Vero/O cells/O infected/O with/O an/O alpha0/I deletion/I mutant/I was/O reduced/O relative/O to/O that/O of/O cells/O infected/O with/O wild/O -/O type/O virus/O or/O a/O recombinant/O virus/O in/O which/O the/O deleted/O alpha0/I sequences/I were/O restored/O ./O
We/O report/O the/O preliminary/O biochemical/O characterization/O of/O the/O T/I antigens/I encoded/O by/O three/O SV40/O mutants/O ,/O 5030/O ,/O 5031/O ,/O and/O 5061/O ,/O each/O of/O which/O have/O altered/O residues/O within/O or/O near/O the/O ATP/O binding/O pocket/O ./O
These/O effects/O were/O abrogated/O by/O co/O -/O expression/O of/O kinase/I -/I deficient/I PKC/I zeta/I and/O inhibition/O of/O phosphatidylinositol/I 3/I -/I kinase/I p85alpha/I -/O p110/I by/O wortmannin/O ,/O LY294002/O and/O a/O dominant/O -/O negative/O mutant/O of/O p85alpha/I ./O
Protein/I phosphatase/I 2A/I is/O a/O critical/O regulator/O of/O protein/I kinase/I C/I zeta/I signaling/O targeted/O by/O SV40/I small/I t/I to/O promote/O cell/O growth/O and/O NF/I -/I kappaB/I activation/O ./O
Interestingly/O ,/O the/O RXRalphaF318A/I constitutive/O activity/O generated/O within/O heterodimers/O in/O the/O presence/O of/O BMS614/O requires/O the/O integrity/O of/O both/O RXR/I and/O RAR/I AF/O -/O 2/O domains/O ./O
These/O introns/O contain/O only/O single/O snoRNA/I genes/I and/O their/O processing/O involves/O exonucleolytic/O release/O of/O the/O snoRNA/O from/O debranched/O intron/O lariats/O ./O
Recent/O studies/O have/O shown/O that/O the/O Src/I homology/I -/I 2/I (/O SH2/I )/O domain/O -/O containing/O protein/I -/I tyrosine/I phosphatase/I ,/O SHP/I -/I 2/I ,/O associates/O with/O the/O cytoplasmic/O domain/O of/O PECAM/I -/I 1/I as/O it/O becomes/O tyrosine/O -/O phosphorylated/O during/O platelet/O aggregation/O :/O a/O process/O that/O can/O be/O mimicked/O in/O part/O by/O small/O synthetic/O phosphopeptides/O corresponding/O to/O the/O cytoplasmic/O domain/O of/O PECAM/I -/I 1/I encompassing/O tyrosine/O residues/O Tyr/O -/O 663/O or/O Tyr/O -/O 686/O ./O
Underlying/O the/O clustering/O of/O these/O risk/O variables/O were/O three/O factors/O ./O
Supplementation/O was/O stopped/O when/O pl/I -/I ALB/I reached/O 2/O ./O 0/O g/O //O dL/O ./O
Detection/O of/O airborne/O Mycobacterium/O tuberculosis/O by/O air/O filtration/O and/O polymerase/O chain/O reaction/O ./O
These/O findings/O show/O that/O EBP50/I is/O a/O physiologically/O relevant/O ezrin/I binding/I protein/I ./O
Previously/O ,/O we/O reported/O that/O scanthrough/O translation/O ,/O where/O the/O initiating/O AUG/O of/O a/O primary/O open/O reading/O frame/O is/O bypassed/O ,/O is/O most/O likely/O to/O account/O for/O the/O presentation/O of/O cryptic/O epitopes/O from/O alternative/O reading/O frames/O within/O the/O influenza/I A/I PR/I //I 8/I //I 34/I nucleoprotein/I gene/I ./O
This/O family/O of/O proteins/O binds/O GC/O -/O rich/O motifs/O widely/O distributed/O in/O gene/O promoters/O ,/O resulting/O in/O distinct/O activation/O or/O repression/O of/O transcriptional/O activities/O ./O
Deletion/O of/O the/O POR2/I gene/I alone/O had/O no/O detectable/O phenotype/O ,/O while/O yeasts/O with/O deletions/O of/O both/O the/O POR1/I and/O POR2/I genes/I were/O viable/O and/O able/O to/O grow/O on/O glycerol/O at/O 30/O degrees/O C/O ,/O albeit/O more/O slowly/O than/O delta/I por1/I single/I mutants/I ./O
Furthermore/O ,/O our/O novel/O observation/O that/O expression/O of/O a/O highly/O activated/O FGFR3/I kinase/I domain/I is/O able/O to/O morphologically/O transform/O fibroblasts/O suggests/O that/O dysregulation/O of/O FGFR3/I has/O the/O potential/O to/O play/O a/O role/O in/O human/O neoplasia/O ./O
The/O deduced/O amino/O acid/O sequence/O of/O the/O gene/O has/O significant/O homology/O to/O the/O interferon/I regulatory/I factors/I (/O IRFs/I )./O
Involvement/O of/O AP/I -/I 2/I in/O regulation/O of/O the/O R/I -/I FABP/I gene/I in/O the/O developing/O chick/O retina/O ./O
However/O ,/O Cbf5p/I was/O found/O to/O be/O nucleolar/O and/O is/O highly/O homologous/O to/O the/O rat/I nucleolar/I protein/I NAP57/I ,/O which/O coimmunoprecipitates/O with/O Nopp140/I and/O which/O is/O postulated/O to/O be/O involved/O in/O nucleolar/O -/O cytoplasmic/O shuttling/O (/O U/O ./O
This/O newly/O described/O organism/O was/O difficult/O to/O identify/O due/O to/O discrepancies/O between/O the/O Vitek/O and/O API/O 20E/O identification/O systems/O ./O
Ig/I heavy/I chain/I class/O switching/O is/O directed/O by/O cytokines/O inducing/O transcription/O from/O unrearranged/O CH/I genes/I ./O
The/O available/O data/O suggest/O that/O the/O NF/I kappa/I B2/I nucleoprotein/I complex/I may/O cooperate/O with/O DNA/O -/O bound/O STAT6/I to/O achieve/O IL/I -/I 4/I -/O dependent/O activation/O of/O the/O human/I IgE/I germline/I gene/I ./O
EXERCISE/O IN/O THE/O TERRESTRIAL/O CHRISTMAS/O ISLAND/O RED/O CRAB/O GECARCOIDEA/O NATALIS/O -/O ENERGETICS/O OF/O LOCOMOTION/O
THE/O SCALING/O OF/O SONG/O FREQUENCY/O IN/O CICADAS/O
The/O pheromone/O response/O pathway/O activates/O transcription/O of/O Ty5/I retrotransposons/I located/O within/O silent/O chromatin/O of/O Saccharomyces/O cerevisiae/O ./O
In/O this/O study/O we/O have/O introduced/O mutations/O into/O the/O corresponding/O elements/O of/O two/O cox3/I promoters/I and/O show/O that/O while/O the/O core/O element/O is/O essential/O for/O cox3/I promoter/I activity/O ,/O upstream/O element/O mutations/O have/O little/O or/O no/O effect/O ./O
We/O found/O that/O multiple/O tumor/O suppressor/O genes/O (/O e/O ./O g/O .,/O p53/I ,/O DCC/I ,/O APC/I ,/O MCC/I ,/O BRCA1/I ,/O and/O WAF1/I //O CIP1/I )/O were/O inactivated/O at/O different/O frequencies/O via/O various/O mechanisms/O [/O e/O ./O g/O .,/O loss/O of/O heterozygosity/O (/O LOH/O ),/O loss/O of/O expression/O (/O LOE/O ),/O mutation/O ,/O and/O inactivation/O by/O cellular/O binding/O protein/O ]./O
The/O histidine/O -/O tagged/O gene/O ,/O rpoCHIS/I ,/O was/O used/O to/O replace/O the/O wild/O -/O type/O allele/O in/O the/O chromosome/O of/O S/O ./O coelicolor/O and/O S/O ./O lividans/O ./O
Because/O the/O deletion/O included/O the/O TK/I gene/I ,/O selection/O with/O gancyclovir/O against/O cells/O not/O having/O undergone/O recombination/O was/O possible/O ./O
The/O malate/I synthase/I gene/I ,/O MLS1/I ,/O of/O the/O yeast/O Saccharomyces/O cerevisiae/O is/O transcriptionally/O regulated/O by/O the/O carbon/O source/O in/O the/O growth/O medium/O ./O
By/O deletion/O analysis/O of/O the/O MLS1/I control/O region/O ,/O we/O identified/O two/O sites/O ,/O UAS1/O and/O UAS2/O ,/O as/O important/O for/O efficient/O derepression/O of/O the/O gene/O ./O
Lack/O of/O controlled/O prospective/O studies/O of/O sleep/O electroencephalograms/O (/O EEG/O ),/O and/O the/O use/O of/O medication/O ,/O in/O children/O with/O developmental/O dysphasia/O ,/O may/O deny/O appropriate/O treatment/O strategies/O to/O children/O with/O severe/O developmental/O speech/O and/O language/O disorders/O ./O
Prior/O to/O meals/O 2/O to/O 3/O times/O daily/O ,/O 1/O -/O 2/O tablespoons/O of/O Alzoon/O are/O recommended/O ./O
Widening/O of/O the/O abdominal/O aortic/O wall/O on/O an/O ultrasound/O examination/O was/O the/O key/O to/O the/O incidental/O diagnosis/O of/O a/O clinically/O unsuspected/O type/O B/O dissection/O ./O
Fermentation/O process/O after/O supplementation/O of/O nitrate/O ,/O nitrite/O ,/O lactic/O acid/O bacteria/O and/O formic/O acid/O
Substrates/O include/O the/O p21/I (/O ras/I )/O proteins/O ,/O nuclear/I lamins/I ,/O and/O a/O series/O of/O retinal/O proteins/O ./O
Ovaries/O of/O 10/O animals/O per/O group/O from/O 16/O studies/O in/O CD/O -/O 1/O mice/O and/O 1/O study/O each/O in/O C3H/O and/O C57BL/O //O 6/O mice/O were/O sectioned/O serially/O at/O 6/O microm/O ./O
The/O Trx/I -/O CT/I fusion/O protein/O was/O produced/O less/O efficiently/O (/O 20/O %/O of/O total/O soluble/O cellular/O protein/O )./O
These/O results/O suggest/O that/O UBP41/I may/O play/O an/O important/O role/O in/O the/O recycling/O of/O ubiquitin/I by/O hydrolysis/O of/O branched/I poly/I -/I ubiquitin/I chains/I generated/O by/O the/O action/O of/O 26/I S/I proteasome/I on/O poly/O -/O ubiquitinated/O protein/O substrates/O ,/O as/O well/O as/O in/O the/O production/O of/O free/O ubiquitin/I from/O linear/I poly/I -/I ubiquitin/I chains/I and/O of/O certain/O ribosomal/O proteins/O from/O ubiquitin/I fusion/I proteins/I ./O
A/O data/O base/O homology/O search/O revealed/O that/O the/O predicted/O ER1/I amino/O acid/O sequence/O contains/O three/O regions/O of/O similarity/O to/O the/O rat/O and/O human/O proteins/O encoded/O by/O the/O metastasis/O -/O associated/O gene/O ,/O mta1/I ,/O and/O two/O regions/O of/O similarity/O to/O the/O Caenorhabditis/O elegans/O sequence/O that/O is/O similar/O to/O mta1/I ./O
The/O sequenced/O cDNA/O predicts/O a/O 704/O -/O amino/O acid/O protein/O 80/O %/O identical/O to/O human/I progelatinase/I B/I ./O
The/O inhibition/O by/O cytosolic/O Ca2/O +/O was/O caused/O by/O a/O decrease/O in/O cooperativity/O and/O by/O a/O shift/O in/O EC50/O toward/O higher/O InsP3/O concentrations/O ./O
RESULTS/O :/O The/O standardised/O mortality/O ratio/O (/O SMR/O )/O for/O all/O malignant/O neoplasms/O was/O 94/O (/O 95/O %/O CI/O 74/O to/O 118/O )./O
Sequence/O analysis/O of/O this/O region/O revealed/O three/O eight/O -/O bp/O repetitive/O elements/O ,/O the/O deletion/O of/O which/O restored/O wild/O -/O type/O levels/O of/O luciferase/I activity/O to/O the/O -/O 916/O -/O bp/O reporter/O plasmid/O ./O
Using/O 5/O '/O RACE/O and/O reverse/O transcription/O -/O PCR/O (/O RT/O -/O PCR/O )/O methodologies/O ,/O we/O cloned/O these/O sequences/O from/O brain/O and/O placenta/O and/O found/O this/O material/O to/O be/O composed/O of/O alternatively/O spliced/O exons/O using/O a/O previously/O reported/O noncoding/O exon/O (/O 1A/O )/O and/O a/O novel/O 97/O -/O bp/O noncoding/O exon/O (/O 1B/O )./O
This/O is/O the/O first/O study/O in/O which/O mutation/O screening/O has/O been/O performed/O for/O both/O the/O EXT1/I and/O EXT2/I genes/I prior/O to/O any/O linkage/O analysis/O ./O
The/O regurgitation/O of/O large/O vitreous/O injections/O ./O
Positron/O emission/O tomography/O radioligands/O for/O dopamine/I transporters/I and/O studies/O in/O human/O and/O nonhuman/O primates/O ./O
Attenuation/O from/O the/O vit/I A2/I consensus/O ERE/O is/O not/O necessarily/O dependent/O on/O DNA/O binding/O as/O the/O TR/I alpha/I DNA/O binding/O mutant/O was/O still/O able/O to/O inhibit/O E/O -/O dependent/O transactivation/O ./O
Expression/O from/O this/O element/O is/O regulated/O by/O a/O heteromeric/O protein/O complex/O containing/O ubiquitous/O (/O i/O ./O e/O ./O the/O E2A/I -/O and/O HEB/I -/I encoded/I proteins/I )/O and/O islet/O -/O enriched/O members/O of/O the/O bHLH/I family/I ./O
Thus/O ,/O the/O CCAAT/O box/O also/O has/O tissue/O -/O specific/O characteristics/O that/O assist/O in/O targeting/O expression/O of/O the/O alpha/I -/I subunit/I gene/I to/O trophoblasts/O ./O
U4/I //O U6/I snRNP/O is/O one/O of/O four/O essential/O small/O nuclear/O ribonucleoprotein/O (/O snRNP/O )/O particles/O (/O U1/I ,/O U2/I ,/O U5/I and/O U4/I //O U6/I )/O present/O in/O the/O spliceosome/O ./O
Hprp3p/I is/O a/O 77/O kDa/O protein/O ,/O which/O is/O homologous/O to/O the/O Saccharomyces/I cerevisiae/I splicing/I factor/I Prp3p/I ./O
The/O growth/O -/O promoting/O properties/O of/O the/O retroviral/I v/I -/I erbA/I oncogene/I ,/O a/O highly/O mutated/O version/O of/O the/O chicken/I thyroid/I hormone/I receptor/I (/I TR/I )/I alpha/I ,/O have/O so/O far/O exclusively/O been/O linked/O to/O dominant/O repression/O of/O the/O antimitogenic/O roles/O of/O TR/I and/O retinoic/I acid/I receptors/I ./O
We/O cloned/O a/O complete/O cDNA/O (/O 2/O ./O 9/O kb/O )/O for/O HET/I from/O an/O MCF/O -/O 7/O cDNA/O library/O ./O
The/O most/O common/O grade/O 3/O toxicity/O was/O neutropenia/O ,/O thrombocytopenia/O ,/O and/O parasthesias/O (/O observed/O in/O /O 2000/O pg/O //O ml/O is/O a/O strong/O positive/O predictor/O of/O CAM/O ./O
A/O positive/O correlation/O between/O serum/I myoglobin/I and/O CA/I III/I concentrations/O (/O rs/O =/O 0/O ./O 933/O ,/O P/O /O 150/O kb/O genomic/O DNA/O ./O
Transfection/O analyses/O indicated/O that/O the/O expression/O of/O Tbxas1/I is/O controlled/O by/O a/O short/O (/O 70/O -/O bp/O )/O positive/O regulatory/O sequence/O and/O several/O upstream/O repressive/O elements/O ./O
The/O results/O of/O this/O study/O suggest/O that/O NF/I -/I kappaB/I activity/O may/O be/O regulated/O by/O its/O interaction/O with/O the/O cell/O cycle/O regulatory/O protein/O ,/O E2F/I -/I 1/I ./O
The/O lysozyme/I FEF/I site/O is/O immediately/O 5/O '/O to/O a/O PU/I ./O
Osteocalcin/I (/O OC/I )/O is/O a/O matrix/I calcium/I -/I binding/I protein/I expressed/O in/O osteoblasts/O and/O odontoblasts/O undergoing/O mineralization/O ./O
In/O this/O study/O ,/O we/O examine/O the/O effects/O of/O Msx2/I expression/O on/O OC/I promoter/I activation/O (/O luciferase/I reporter/I )/O by/O FGF2/I //O FSK/I and/O calcitriol/O in/O MC3T3/O -/O E1/O osteoblasts/O ./O
Thus/O ,/O unlike/O other/O proteins/O reported/O to/O inhibit/O SRF/I activity/O ,/O the/O repressor/O activity/O associated/O with/O the/O GC/O -/O rich/O element/O does/O not/O appear/O to/O function/O through/O direct/O inhibition/O of/O SRF/I binding/O ./O
However/O ,/O one/O CAK/I -/O phosphorylated/O phosphopeptide/O comigrates/O with/O a/O Cdc2/I -/O phosphorylated/O phosphopeptide/O previously/O shown/O to/O be/O mitosis/O -/O specific/O ,/O suggesting/O that/O ,/O in/O vitro/O ,/O CAK/I is/O able/O to/O phosphorylate/O at/O least/O one/O site/O that/O is/O also/O phosphorylated/O in/O vivo/O ./O
The/O pen/O can/O heal/O ./O
The/O mHIF/I -/I 1/I alpha/I structural/I gene/I is/O composed/O of/O 15/O exons/O ./O
However/O ,/O when/O a/O second/O ,/O upstream/I IRE/I -/I like/I sequence/I was/O evaluated/O by/O EMSA/O ,/O a/O DNA/O binding/O pattern/O distinct/O from/O that/O seen/O following/O exposure/O to/O IFN/I -/I gamma/I alone/O was/O observed/O after/O prolonged/O stimulation/O with/O both/O IFN/I -/I alpha/I and/O IFN/I -/I gamma/I ./O
In/O Arabidopsis/O ,/O the/O induction/O of/O a/O dehydration/O -/O responsive/O gene/O ,/O rd22/I ,/O is/O mediated/O by/O abscisic/O acid/O (/O ABA/O )/O and/O requires/O protein/O biosynthesis/O for/O ABA/O -/O dependent/O gene/O expression/O ./O
A/O cDNA/O encoding/O a/O MYC/I -/I related/I DNA/I binding/I protein/I was/O isolated/O by/O DNA/O -/O ligand/O binding/O screening/O ,/O using/O the/O 67/O -/O bp/O region/O as/O a/O probe/O ,/O and/O designated/O rd22BP1/I ./O
Human/I PDK1/I is/O homologous/O to/O the/O Drosophila/I protein/I kinase/I DSTPK61/I ,/O which/O has/O been/O implicated/O in/O the/O regulation/O of/O sex/O differentiation/O ,/O oogenesis/O and/O spermatogenesis/O ./O
Thus/O ,/O the/O synergistic/O effects/O of/O HNF/I -/I 1beta/I and/O the/O GR/I on/O dexamethasone/O -/O stimulated/O promoter/O activity/O require/O that/O they/O are/O bound/O to/O the/O HNF/I -/I 1/I site/I and/O the/O GRE/O ,/O respectively/O ,/O and/O may/O involve/O protein/O -/O protein/O interactions/O between/O the/O transcription/O factors/O ,/O or/O between/O them/O and/O the/O basal/O transcription/O machinery/O or/O a/O steroid/I receptor/I coactivator/I ./O
Mutational/O analysis/O shows/O that/O both/O an/O AP/I -/I 1/I like/I sequence/I (-/O 294/O /-/O 285/O ,/O TGAATCATCA/O )/O and/O an/O A/O //O T/O -/O rich/O myocyte/I enhancer/I factor/I (/I MEF/I )-/I 2/I like/I sequence/I (-/O 310/O /-/O 298/O ,/O TTAAAAATAAAAA/O )/O in/O the/O 33/O -/O bp/O region/O are/O necessary/O for/O the/O OP/I -/I 1/I effect/O ./O
Unlike/O most/O other/O members/O of/O the/O Bcl/I -/I 2/I family/I ,/O BAD/I (/O Bcl/I -/I xL/I //I Bcl/I -/I 2/I associated/I death/I promoter/I ),/O a/O death/I enhancer/I ,/O has/O no/O C/O -/O terminal/O transmembrane/O domain/O for/O targeting/O to/O the/O outer/O mitochondrial/O membrane/O and/O nuclear/O envelope/O ./O
Electromobility/O shift/O and/O cotransfection/O assays/O demonstrated/O that/O HNF1alpha/I ,/O but/O not/O HNF4/I ,/O bound/O to/O its/O cognate/O site/O and/O transactivated/O G6Pase/I gene/I expression/O ./O
An/O open/O reading/O frame/O of/O 2862/O bp/O encoding/O a/O 954/O amino/O acid/O protein/O was/O identified/O ./O
One/O of/O these/O ,/O an/O AACA/O motif/O ,/O has/O been/O shown/O to/O be/O a/O negative/O regulator/O in/O non/O -/O seed/O tissues/O and/O has/O a/O similarity/O to/O the/O barley/O gibberellin/O responsive/O element/O recognized/O by/O MYB/I -/I like/I DNA/I binding/I proteins/I ./O
Strain/O CFN037/O is/O an/O R/O ./O etli/O mutant/O induced/O by/O a/O single/O Tn5mob/I insertion/O in/O the/O promoter/O region/O of/O the/O thiCOGE/I gene/I cluster/I ./O
Expression/O of/O thiamin/O biosynthetic/O genes/O (/O thiCOGE/I )/O and/O production/O of/O symbiotic/I terminal/I oxidase/I cbb3/I in/O Rhizobium/O etli/O ./O
We/O have/O cloned/O and/O sequenced/O a/O region/O encoding/O a/O lipase/I operon/I and/O a/O putative/O ,/O previously/O uncharacterized/O metalloprotease/I of/I Vibrio/I cholerae/I O1/I ./O
Furthermore/O ,/O the/O amount/O of/O tRNA/I (/I 3Lys/I )/I that/O was/O placed/O onto/O viral/O RNA/O in/O mutated/O viruses/O was/O significantly/O less/O than/O that/O placed/O in/O the/O wild/O -/O type/O virus/O ./O
This/O protein/O is/O present/O in/O both/O HeLa/O nuclear/O extracts/O and/O S100/I extracts/O but/O absent/O from/O SR/I protein/I preparations/O ,/O suggesting/O that/O it/O is/O not/O a/O classical/O SR/I protein/I ./O
Differential/O regulation/O of/O the/O pre/I -/I C/I and/O pregenomic/O promoters/O of/O human/O hepatitis/O B/O virus/O by/O members/O of/O the/O nuclear/I receptor/I superfamily/I ./O
Acad/O ./O
Chimeras/O containing/O IE1/I peptides/I dramatically/O activated/O transcription/O of/O the/O basal/O promoter/O only/O when/O lac/I operator/I sequences/I were/O present/O ./O
The/O results/O of/O replicase/I assays/O performed/O with/O mutant/I VP2/I containing/O a/O deletion/O in/O its/O RNA/O -/O binding/O domain/O suggests/O that/O the/O essential/O role/O for/O VP2/I in/O replication/O is/O linked/O to/O the/O protein/O '/O s/O ability/O to/O bind/O the/O mRNA/O template/O for/O minus/O -/O strand/O synthesis/O ./O
We/O previously/O described/O two/O alanine/O cluster/O mutations/O ,/O R77/O to/O A/O (/O R77A/O )-/O K79A/O and/O E192A/O -/O E194A/O ,/O which/O selectively/O inactivated/O the/O triphosphatase/O component/O ./O
Transfection/O of/O HepG2/O and/O SK/O -/O N/O -/O MC/O cells/O with/O constructs/O deleted/O of/O additional/O 5/O '-/O flanking/O fragments/O permitted/O the/O definition/O of/O a/O minimal/O 200/O bp/O promoter/O fragment/O containing/O the/O pseudo/O -/O TATA/O box/O and/O two/O putative/O SP1/I -/I binding/I sites/I ./O
Both/O inserts/O are/O larger/O than/O their/O homologues/O in/O eIF/I -/I 2alpha/I kinases/I ./O
Three/O monopolar/O electrodes/O were/O inserted/O into/O the/O left/O and/O right/O lateral/O vestibulospinal/O tract/O (/O LVST/O )/O and/O medial/O vestibulospinal/O tract/O (/O MVST/O )/O of/O the/O C1/O segment/O ,/O to/O determine/O the/O pathway/O of/O axons/O ./O
Epitopes/O of/O adhesion/O -/O perturbing/O monoclonal/O antibodies/O map/O within/O a/O predicted/O alpha/O -/O helical/O domain/O of/O the/O integrin/I beta/I 1/I subunit/I ./O
Polyhomeotic/I and/I Posterior/I Sex/I Combs/I may/O participate/O in/O a/O more/O general/O transcriptional/O mechanism/O that/O causes/O modulated/O gene/O repression/O ,/O whereas/O the/O inclusion/O of/O Polycomb/I protein/I in/O the/O complex/O at/O PREs/I leads/O to/O stable/O silencing/O ./O
Furthermore/O ,/O both/O rhHR23/I proteins/I function/O in/O a/O defined/O NER/O system/O reconstituted/O with/O purified/O proteins/O ,/O indicating/O direct/O involvement/O of/O hHR23/I proteins/I in/O the/O DNA/O repair/O reaction/O via/O interaction/O with/O XPC/I ./O
The/O yeast/O silent/I information/I regulator/I Sir4p/I anchors/O and/O partitions/O plasmids/O ./O
These/O results/O implicate/O a/O precursor/O -/O specific/O base/O -/O paired/O structure/O involving/O sequences/O on/O both/O sides/O of/O the/O mature/O cleavage/O site/O in/O the/O 3/O '/O processing/O of/O human/I U2/I RNA/I ./O
Polysome/O analyses/O in/O a/O temperature/O -/O sensitive/O fal1/I -/I 1/I mutant/I and/O a/O Fal1p/I -/O depleted/O strain/O reveal/O a/O decrease/O in/O the/O number/O of/O 40S/I ribosomal/I subunits/I ./O
Sequence/O analysis/O identified/O some/O of/O these/O cDNA/O clones/O as/O Dlc/I -/I 1/I ,/O a/O sequence/O encoding/O a/O small/O ,/O 9/I -/I kDa/I human/I homolog/I of/I the/I outer/I -/I arm/I dynein/I light/I -/I chain/I protein/O ./O
Importantly/O ,/O in/O HeLa/O and/O 293/O cells/O ,/O endogenous/O and/O transfected/O I/I kappaB/I alpha/I coimmunoprecipitated/O with/O Myc/I -/O tagged/O or/O endogenous/O Dlc/I -/I 1/I ./O
The/O mouse/I M/I -/I lysozyme/I downstream/I enhancer/I has/O been/O previously/O characterized/O on/O several/O levels/O of/O gene/O regulation/O ./O
Identification/O of/O dynein/I heavy/I chain/I genes/I expressed/O in/O human/O and/O mouse/O testis/O :/O chromosomal/O localization/O of/O an/O axonemal/I dynein/I gene/I ./O
Bitter/O cassava/O contains/O cyanogenic/O glycosides/O ;/O processing/O breaks/O them/O down/O to/O acetone/O cyanohydrin/O and/O hydrogen/O cyanide/O ./O
The/O proposed/O mechanism/O of/O effect/O states/O that/O mono/O (/O 2/O -/O ethylhexyl/O )/O phthalate/O (/O MEHP/O ),/O the/O primary/O hydrolysis/O product/O of/O DEHP/O ,/O mimics/O the/O inducing/O prostaglandins/O (/O PG/O )/O PGD/O (/O 2/O ),/O 9alpha/O ,/O 11betaPGF2/O ,/O and/O PGF2alpha/O ,/O and/O thromboxanes/O in/O the/O lungs/O ,/O thereby/O increasing/O the/O risk/O of/O inducing/O inflammation/O in/O the/O airways/O ,/O which/O is/O a/O characteristic/O of/O asthma/O ./O
We/O found/O 14/O protein/O binding/O sites/O that/O were/O occupied/O in/O vivo/O ./O
Constitutive/O protection/O of/O E2F/I recognition/I sequences/I in/O the/O human/I thymidine/I kinase/I promoter/I during/O cell/O cycle/O progression/O ./O
Comparison/O of/O genomic/O sequence/O shows/O that/O the/O ph/I locus/I has/O been/O duplicated/O ,/O and/O that/O it/O contains/O proximal/O and/O distal/O transcription/O units/O ./O
Radiation/O decreased/O the/O levels/O of/O T4/O and/O T3/O 6/O h/O and/O 72/O h/O in/O group/O C/O ,/O in/O group/O A/O at/O 72/O h/O ,/O in/O group/O B/O at/O 24/O h/O postexposure/O ./O
We/O have/O reviewed/O the/O experience/O of/O a/O major/O MMT/O general/O practice/O with/O hepatitis/O C/O virus/O (/O HCV/O )/O infection/O from/O 1991/O to/O 1995/O ./O
The/O author/O analyzes/O extensive/O own/O data/O based/O on/O study/O into/O particular/O features/O of/O cardiovascular/O disorders/O in/O chronic/O renal/O impairement/O with/O making/O use/O of/O modern/O diagnostic/O tools/O ./O
In/O this/O paper/O ,/O characterization/O is/O given/O of/O clinical/O and/O biochemical/O features/O of/O VH/O B/O course/O against/O the/O background/O of/O narcomania/O ./O
447/O microns/O for/O A/O ./O microcephalum/O and/O 350/O microns/O for/O A/O ./O wedli/O ),/O and/O fewer/O testes/O per/O proglottis/O (/O 44/O -/O 73/O vs/O ./O
The/O ZnF20/I cDNA/I hybridized/O to/O multiple/O transcripts/O in/O a/O thyroid/O cancer/O cell/O line/O (/O 8/O ./O 0/O ,/O 4/O ./O 5/O and/O 2/O kb/O )/O that/O increased/O after/O cycloheximide/O treatment/O and/O decayed/O /O DR/O -/O 4/O >/O IRhsp/O -/O 1/O )./O
The/O high/O density/O of/O tegumental/O spines/O on/O posterior/O half/O of/O the/O body/O and/O the/O distribution/O of/O type/O II/O papillae/O on/O dorsal/O surface/O are/O considered/O to/O be/O characteristic/O of/O C/O ./O armatus/O ./O
Inactivation/O of/O p53/I but/O not/O p73/I by/O adenovirus/I type/I 5/I E1B/I 55/I -/I kilodalton/I and/I E4/I 34/I -/I kilodalton/I oncoproteins/I ./O
The/O Epstein/I -/I Barr/I virus/I transactivator/I Zta/I triggers/O lytic/O gene/O expression/O and/O is/O essential/O for/O replication/O of/O the/O lytic/O origin/O ,/O oriLyt/O ./O
Cotransfection/O of/O the/O helicase/I -/O primase/I proteins/O ,/O one/O of/O which/O was/O fused/O to/O a/O heterologous/O activation/O domain/O ,/O led/O to/O Zta/I -/O dependent/O superactivation/O of/O CAT/I expression/O ./O
Sequence/O comparisons/O strongly/O suggest/O that/O the/O S27a/I and/O the/O ubiquitin/I coding/O sequences/O found/O in/O the/O genome/O of/O CP/O Rit/O were/O both/O derived/O from/O a/O bovine/O mRNA/O encoding/O a/O hybrid/O protein/O with/O the/O structure/O NH2/O -/O ubiquitin/I -/O S27a/I -/O COOH/O ./O
J/O ./O
There/O was/O a/O trend/O in/O all/O studies/O favouring/O PVI/O ./O
A/O single/O rectal/O dose/O of/O 25/O mg/O //O kg/O will/O obtain/O this/O lower/O concentration/O within/O 1/O h/O of/O administration/O and/O maintain/O it/O for/O up/O to/O 6/O h/O ./O
This/O domain/O ,/O although/O adjacent/O to/O the/O 5/O '/O edge/O of/O the/O SD/O sequence/O ,/O does/O not/O inhibit/O ribosome/O binding/O as/O long/O as/O the/O single/O -/O stranded/O region/O of/O domain/O 3/O is/O present/O ./O
Although/O YopH/I is/O a/O highly/O active/O PTP/I ,/O it/O preferentially/O targets/O a/O subset/O of/O tyrosine/O -/O phosphorylated/O proteins/O in/O host/O cells/O ,/O including/O p130Cas/I ./O
Phylogenetic/O position/O of/O the/O Phacotaceae/O within/O the/O Chlamydophyceaeas/O revealed/O by/O analysis/O of/O 18S/I rDNA/I and/O rbcL/I sequences/I ./O
Previous/O genetic/O studies/O led/O to/O the/O conclusion/O that/O nitrate/O and/O nitrite/O induction/O of/O nasF/I operon/I expression/O is/O determined/O by/O a/O transcriptional/O antitermination/O mechanism/O ./O
The/O activation/O and/O injury/O of/O endothelial/O cells/O induced/O by/O TNF/I and/O other/O proinflammatory/O cytokines/O may/O underlie/O the/O local/O effects/O of/O these/O mediators/O in/O vivo/O ./O
A/O technique/O for/O thermal/O imaging/O of/O the/O animal/O and/O human/O brain/O cortex/O using/O an/O infrared/O optical/O system/O is/O described/O ./O
EGFR/I levels/O were/O found/O to/O be/O elevated/O 5/O -,/O 3/O ./O
Here/O we/O demonstrate/O that/O THOV/I NP/I contains/O a/O motif/O (/O KRxxxxxxxxxKTKK/O )/O at/O amino/O acid/O positions/O 179/O -/O 193/O that/O represents/O a/O classical/O bipartite/O nuclear/O localization/O signal/O (/O NLS/O )./O
As/O PP2A/I exerts/O a/O range/O of/O cellular/O functions/O including/O cell/O cycle/O regulation/O and/O cell/O fate/O determination/O ,/O we/O were/O surprised/O to/O find/O that/O these/O embryos/O develop/O normally/O until/O postimplantation/O ,/O around/O embryonic/O day/O 5/O ./O 5/O //O 6/O ./O 0/O ./O
The/O most/O frequent/O risk/O factor/O for/O ischaemic/O was/O hypertension/O ./O
The/O results/O indicate/O that/O anthraquinone/O sennoside/O B/O and/O rhein/O are/O weakly/O genotoxic/O ./O
Furthermore/O ,/O LB1/I gene/I mapped/O to/O chromosome/O 13q14/O ,/O a/O region/O that/O has/O been/O involved/O as/O a/O chromosomal/O breakpoint/O in/O DLBL/O ./O
16/O subjects/O were/O repatch/O tested/O to/O ethylmercury/O chloride/O (/O EtHgCl/O )/O and/O to/O solutions/O containing/O EtHgCl/O mixed/O with/O L/O -/O cysteine/O and/O glutathione/O ,/O respectively/O ./O
Wild/I -/I type/I AT1A/I receptors/I ,/O expressed/O in/O Chinese/O hamster/O ovary/O cells/O ,/O rapidly/O internalized/O after/O Ang/I II/I stimulation/O [/O t1/O //O 2/O 2/O ./O 3/O min/O ;/O maximal/O level/O of/O internalization/O (/O Ymax/O )/O 78/O ./O 2/O %],/O as/O did/O mutant/O receptors/O carrying/O single/O acidic/O substitutions/O (/O T332E/O ,/O t1/O //O 2/O 2/O ./O 7/O min/O ,/O Ymax/O 76/O ./O 3/O %;/O S335D/O ,/O t1/O //O 2/O 2/O ./O 4/O min/O ,/O Ymax/O 76/O ./O 7/O %;/O T336E/O ,/O t1/O //O 2/O 2/O ./O 5/O min/O ,/O Ymax/O 78/O ./O 2/O %;/O S338D/O ,/O t1/O //O 2/O 2/O ./O 6/O min/O ,/O Ymax/O 78/O ./O 4/O %)./O
The/O activated/O glucocorticoid/I receptor/I forms/O a/O complex/O with/O Stat5/I and/O enhances/O Stat5/I -/O mediated/O transcriptional/O induction/O ./O
T/O .,/O Mahasneh/O ,/O A/O .,/O and/O Cote/O ,/O G/O ./O
The/O carboxyl/O -/O terminal/O portion/O of/O UKLF/I contains/O three/O zinc/O fingers/O of/O the/O Cys2/O -/O His2/O type/O and/O binds/O in/O vitro/O to/O the/O CACCC/O motif/O of/O the/O beta/I -/I globin/I promoter/I and/O to/O the/O Sp1/I recognition/I sequence/I ./O
We/O have/O recently/O identified/O a/O mouse/O enzyme/O termed/O gamma/I -/I glutamyl/I leukotrienase/I (/O GGL/I )/O that/O converts/O leukotriene/O C4/O (/O LTC4/O )/O to/O leukotriene/O D4/O (/O LTD4/O )./O
UGA/O codon/O position/O affects/O the/O efficiency/O of/O selenocysteine/O incorporation/O into/O glutathione/I peroxidase/I -/I 1/I ./O
Forskolin/O significantly/O enhanced/O heregulin/I -/O stimulated/O expression/O of/O cyclin/I D/I and/O phosphorylation/O of/O the/O retinoblastoma/I gene/I product/I ./O
The/O ARF/I promoter/I was/O also/O found/O to/O be/O highly/O responsive/O to/O E2F1/I expression/O ,/O in/O keeping/O with/O previous/O results/O at/O the/O RNA/O level/O ./O
RESULTS/O :/O The/O binding/O of/O 99mTc/O d/O ,/O 1/O -/O HMPAO/O to/O human/O placenta/O ranged/O from/O 2/O ./O 95/O %/O +/-/O 1/O ./O 5/O %/O to/O 5/O ./O 82/O %/O +/-/O 0/O ./O 3/O %/O per/O 1/O ml/O standard/O solution/O ./O
CM/O reduced/O the/O nuclear/O binding/O activity/O of/O transcription/I factor/I AP/I -/I 1/I ./O
NF/I -/I kappaB/I ,/O which/O is/O probably/O important/O for/O basal/O activity/O of/O the/O human/I NOS/I II/I promoter/I ,/O is/O unlikely/O to/O function/O as/O a/O major/O effector/O of/O CM/O in/O DLD/O -/O 1/O cells/O ./O
Observers/O with/O brain/O injury/O and/O control/O participants/O performed/O a/O vigilance/O task/O during/O which/O they/O received/O periodic/O whiffs/O of/O unscented/O air/O or/O air/O scented/O with/O peppermint/O ./O
A/O simple/O analytical/O method/O for/O l/O -/O menthol/O by/O high/O -/O performance/O liquid/O chromatography/O with/O a/O polarized/O photometric/O detector/O was/O established/O ./O
RESULTS/O :/O The/O cardiac/O index/O significantly/O changed/O with/O varying/O PaCO2/O levels/O (/O hypocapnia/O ,/O -/O 9/O %;/O hypercapnia/O ,/O 13/O %)./O
After/O measuring/O baseline/O Vmca/O at/O a/O partial/O pressure/O of/O carbon/O dioxide/O in/O arterial/O blood/O (/O PaCO2/O )/O of/O 37/O ./O 7/O +/-/O 4/O ./O 5/O mmHg/O (/O mean/O +/-/O SD/O ),/O measurements/O were/O repeated/O at/O a/O PaCO/O of/O 44/O ./O 2/O +/-/O 3/O ./O 8/O mmHg/O ,/O and/O the/O carbon/O dioxide/O reactivity/O (/O absolute/O value/O :/O cm/O x/O s/O (-/O 1/O )/O x/O mmHg/O (-/O 1/O );/O relative/O value/O :/O percentage/O of/O baseline/O Vmca/O //O mmHg/O )/O was/O calculated/O ./O
Multivariate/O Cox/O survival/O analysis/O identified/O baseline/O EF/O /O 2/O +)/O before/O ablation/O ,/O and/O failure/O to/O exhibit/O improved/O cardiac/O performance/O by/O 1/O month/O after/O ablation/O as/O the/O only/O independent/O predictors/O of/O death/O ./O
We/O have/O developed/O a/O new/O method/O for/O estimation/O of/O regional/O CBF/O (/O rCBF/O )/O and/O cerebrovascular/O reserve/O capacity/O on/O a/O pixel/O -/O by/O -/O pixel/O basis/O by/O means/O of/O dynamic/O magnetic/O resonance/O imaging/O (/O MRI/O )./O
Cost/O -/O effectiveness/O analysis/O provides/O a/O rational/O means/O of/O allocating/O limited/O health/O care/O resources/O by/O allowing/O the/O comparison/O of/O the/O costs/O of/O lipid/O -/O lowering/O therapy/O ,/O in/O particular/O ,/O therapy/O with/O beta/I -/I hydroxy/I -/I beta/I -/I methylglutaryl/I -/I CoA/I (/I coenzyme/I A/I )/I reductase/I inhibitors/O (/O statins/O ),/O with/O the/O costs/O of/O atherosclerosis/O that/O could/O be/O prevented/O by/O lowering/O cholesterol/O ./O
Although/O E2FBP1/I lacks/O the/O transactivation/O domain/O ,/O it/O stimulates/O E2F/I site/O -/O dependent/O transcription/O in/O cooperation/O with/O E2F/I -/I 1/I ./O
Sequencing/O of/O a/O 40/O -/O kb/O DNA/O segment/O of/O the/O FK506/O gene/O cluster/O from/O Streptomyces/O sp/O ./O
The/O predicted/O domain/O structures/O of/O FkbB/I and/O FkbC/I are/O analogous/O to/O that/O of/O FkbA/I and/O comprise/O 30/O fatty/I -/I acid/I -/I synthase/I (/O FAS/I )-/O like/O domains/O arranged/O in/O 6/O modules/O ./O
Analysis/O of/O Msy2/I mRNA/I expression/O in/O prepubertal/O and/O adult/O mouse/O testes/O ,/O and/O in/O isolated/O populations/O of/O germ/O cells/O ,/O reveals/O maximal/O expression/O in/O postmeiotic/O round/O spermatids/O ,/O a/O cell/O type/O with/O abundant/O amounts/O of/O stored/O messenger/O ribonucleoproteins/O ./O
1/O in/O Ho/O Chi/O Minh/O City/O was/O studied/O by/O culture/O and/O latex/O agglutination/O of/O blood/O ,/O cerebrospinal/O fluid/O ,/O urine/O and/O pleural/O fluid/O ./O
Glycogen/O synthesis/O and/O catabolism/O ,/O gluconeogenesis/O ,/O glycolysis/O ,/O motility/O ,/O cell/O surface/O properties/O and/O adherence/O are/O modulated/O by/O csrA/I in/I Escherichia/I coli/I ,/O while/O the/O production/O of/O several/O secreted/O virulence/O factors/O ,/O the/O plant/O hypersensitive/O response/O elicitor/O HrpN/I (/O Ecc/I )/O and/O ,/O potentially/O ,/O other/O secondary/O metabolites/O are/O regulated/O by/O rsmA/I in/I Erwinia/I carotovora/I ./O
The/O cwg2/I -/I 1/I mutation/I was/O identified/O as/O a/O guanine/O to/O adenine/O substitution/O at/O nucleotide/O 604/O of/O the/O coding/O region/O ,/O originating/O the/O change/O A202T/O in/O the/O cwg2p/I ./O
Deletion/O analysis/O revealed/O that/O the/O essential/O domain/O of/O this/O promoter/O ,/O termed/O the/O ORF5/I //I deltaX/I transcript/I promoter/I ,/O mapped/O to/O nucleotides/O 1525/O -/O 1625/O ./O
Some/O of/O the/O peptide/I :/I MBP/I fusions/I were/O also/O analyzed/O using/O surface/O plasmon/O resonance/O ./O
Cardiac/I myosin/I -/I binding/I protein/I C/I (/O MyBP/I -/I C/I ):/O identification/O of/O protein/I kinase/I A/I and/O protein/I kinase/I C/I phosphorylation/O sites/O ./O
Handling/O on/O PND/O 9/O did/O not/O result/O in/O elevated/O CORT/O levels/O in/O any/O of/O the/O groups/O ./O
Analysis/O of/O chromosomal/O DNA/O sequence/O immediately/O downstream/O of/O the/O transposon/O insertion/O identified/O two/O open/O reading/O frames/O ,/O designated/O csrR/I and/O csrS/I ,/O which/O exhibited/O sequence/O similarity/O to/O bacterial/O two/O -/O component/O regulatory/O systems/O ./O
633/O +/-/O 258/O aggregates/O //O ml/O at/O 0/O rpm/O ;/O P/O /O Asn/O )/O into/O this/O domain/O of/O p190/I that/O decreased/O its/O ability/O to/O bind/O guanine/O nucleotide/O when/O expressed/O as/O a/O hemagglutinin/I (/O HA/I )-/O tagged/O protein/O in/O COS/O cells/O ./O
Wild/O type/O HA/I -/O p190/I induced/O a/O phenotype/O of/O rounded/O cells/O with/O long/O ,/O beaded/O extensions/O similar/O to/O that/O seen/O when/O Rho/I function/O is/O disrupted/O by/O ADP/O -/O ribosylation/O ./O
We/O emphasize/O that/O ANCA/I -/O associated/O vasculitis/O is/O another/O important/O complication/O of/O RA/O ./O
The/O downstream/O ,/O TATA/O -/O less/O promoter/O has/O high/O G/O +/O C/O content/O ,/O and/O exon/O 1b/O predominates/O among/O abundantly/O expressed/O mRNA/O species/O ./O
Although/O we/O predicted/O that/O overexpression/O of/O the/O COOH/O -/O terminal/O domains/O ,/O which/O were/O thought/O to/O be/O involved/O in/O the/O regulation/O of/O SREBP/I processing/O ,/O would/O result/O in/O disruption/O of/O the/O SREBP/I -/O dependent/O transcriptional/O regulation/O of/O several/O genes/O ,/O the/O mRNA/O levels/O for/O 3/I -/I hydroxy/I -/I 3/I -/I methylglutaryl/I coenzyme/I A/I (/I HMG/I CoA/I )/I synthase/I in/O these/O two/O cell/O lines/O were/O regulated/O in/O a/O sterol/O -/O dependent/O manner/O ./O
Dry/O matter/O intake/O ,/O apparent/O nutrient/O digestibilities/O ,/O serum/O chemistry/O profiles/O ,/O sphingolipid/O concentrations/O ,/O and/O persistency/O of/O FB1/O in/O tissues/O were/O evaluated/O ./O
However/O ,/O no/O studies/O have/O been/O conducted/O to/O further/O investigate/O this/O potentially/O hazardous/O effect/O of/O lidocaine/O ./O
E/O .,/O Scott/O ,/O J/O ./O
Yap1p/I is/O constitutively/O nuclear/O in/O a/O crm1/I mutant/I ,/O and/O Crm1p/I binds/O to/O a/O nuclear/O export/O sequence/O (/O NES/O )-/O like/O sequence/O in/O Yap1p/I in/O the/O presence/O of/O RanGTP/I ./O
Mean/O intake/O of/O vitamin/O A/O amounted/O to/O 1/O ./O 1/O and/O 0/O ./O 9/O mg/O RE/O //O day/O for/O men/O and/O women/O ,/O respectively/O ;/O the/O contributions/O of/O meat/O ,/O fats/O and/O oils/O ,/O vegetables/O and/O dairy/O products/O to/O total/O intake/O were/O 35/O %,/O 24/O %,/O 16/O %,/O and/O 16/O %,/O respectively/O ./O
Also/O ,/O the/O amplitude/O of/O the/O oscillatory/O potentials/O (/O O1/O +/O O2/O +/O O3/O +/O O4/O )/O was/O significantly/O reduced/O in/O the/O early/O postoperative/O period/O ./O
Furthermore/O ,/O RING1/I overexpression/O results/O in/O enhanced/O expression/O of/O the/O proto/O -/O oncogenes/O c/I -/I jun/I and/O c/I -/I fos/I ./O
The/O yeast/I RER2/I gene/I ,/O identified/O by/O endoplasmic/O reticulum/O protein/O localization/O mutations/O ,/O encodes/O cis/I -/I prenyltransferase/I ,/O a/O key/O enzyme/O in/O dolichol/O synthesis/O ./O
The/O yeast/O retrotransposon/I Ty5/I preferentially/O integrates/O into/O regions/O of/O silent/O chromatin/O ./O
The/O loss/O of/O SKO1/I completely/O restored/O ENA1/I expression/O in/O a/O hog1/I mutant/I and/O partially/O suppressed/O the/O osmotic/O stress/O sensitivity/O ,/O qualifying/O Sko1p/I as/O a/O downstream/O effector/O of/O the/O HOG/I pathway/O ./O
Elevated/O expression/O of/O a/O previously/O uncharacterized/O gene/O ,/O SPP381/I ,/O efficiently/O suppresses/O the/O growth/O and/O splicing/O defects/O of/O a/O temperature/O -/O sensitive/O (/O Ts/O )/O mutant/I prp38/I -/I 1/I ./O
The/O slower/O -/O electrophoretic/O -/O mobility/O form/O of/O p68/I was/O absent/O in/O human/O cells/O in/O G1/O //O S/O and/O appeared/O as/O the/O cells/O entered/O G2/O //O M/O ./O
We/O have/O identified/O amino/O acid/O sequences/O in/O mammalian/O and/O Xenopus/O NeuroD1/I //O BETA2/I that/O are/O necessary/O for/O insulin/I gene/I expression/O and/O ectopic/O neurogenesis/O ./O
Both/O NUP98/I -/O HOXA9/I chimeras/O transformed/O NIH/O 3T3/O fibroblasts/O ,/O and/O this/O transformation/O required/O the/O HOXA9/I domains/I for/O DNA/O binding/O and/O PBX/I interaction/O ./O
Recent/O studies/O have/O suggested/O that/O Y319/O also/O positively/O regulate/O ZAP/I -/I 70/I function/O ./O
Genetic/O and/O molecular/O data/O indicate/O that/O wild/I -/I type/I Pan/I and/O CiD/I compete/O for/O binding/O to/O Arm/I ,/O leading/O to/O a/O compromised/O transduction/O of/O the/O Wg/I signal/O in/O heterozygous/O ciD/I /+/I animals/O and/O to/O a/O dramatic/O enhancement/O of/O the/O gain/O -/O of/O -/O function/O activity/O of/O CiD/I in/O homozygous/O mutants/O ./O
Another/O ORF/O ,/O dda/I ./I 2/I located/O between/O modA/I and/O dda/I ,/O shares/O sequence/O similarity/O with/O sigma70/I ,/O and/O we/O call/O it/O srd/I ./O
The/O location/O of/O the/O IBS/O within/O the/O catB/I structural/I gene/I ,/O the/O cooperativity/O observed/O in/O footprinting/O studies/O and/O phasing/O studies/O suggest/O that/O the/O IBS/O participates/O in/O the/O interaction/O of/O CatR/I with/O the/O upstream/O binding/O sites/O by/O looping/O out/O the/O intervening/O DNA/O ./O
In/O vitro/O transcription/O assays/O demonstrate/O that/O the/O TCA/O -/O cycle/O intermediate/O ,/O fumarate/O ,/O directly/O and/O specifically/O inhibits/O the/O formation/O of/O the/O clcA/I transcript/I ./O
BIAcore/O analysis/O gave/O a/O Kaff/O of/O 4/O ./O 4/O x/O 10/O (/O 10/O )/O M/O -/O 1/O for/O the/O binding/O of/O N/I -/I A3/I to/O T84/I ./I 1/I and/O 2/O ./O 2/O x/O 10/O (/O 10/O )/O M/O -/O 1/O for/O the/O binding/O of/O N/I -/I A3/I to/O T84/I ./I 66/I ./O
Expression/O of/O p130/I (/O Cas/I )/O (/O Cas/I ),/O a/O major/O binding/O protein/O for/O the/O Crk/I SH2/I -/I domain/I ,/O also/O induced/O JNK/I activation/O ,/O which/O was/O blocked/O by/O the/O SH2/I -/I mutant/I of/O Crk/I ./O
Positive/O correlations/O were/O seen/O between/O the/O measurements/O for/O protein/O intake/O (/O r/O =./O 58/O ,/O P/O =./O 0026/O )/O energy/O intake/O (/O r/O =./O 78/O ,/O P/O <./O 00001/O ),/O with/O mean/O differences/O of/O ./O 066/O g/O //O kg/O //O d/O (/O SD/O ./O 38/O )/O 2/O ./O 04/O kcal/O //O kg/O //O day/O (/O SD/O 6/O ./O 67/O ),/O respectively/O ./O
The/O Og4C3/I enzyme/O -/O linked/O immunosorbent/O assay/O (/O ELISA/O )/O to/O detect/O circulating/O Wuchereria/I bancrofti/I antigen/I uses/O 50/O microL/O of/O serum/O ./O
We/O now/O show/O that/O gp200/I -/O MR6/I ligation/O can/O also/O mimic/O IL/I -/I 4/I and/O have/O an/O anti/O -/O proliferative/O pro/O -/O maturational/O influence/O within/O the/O immune/O system/O ,/O causing/O up/O -/O regulation/O of/O co/O -/O stimulatory/O molecules/O on/O B/O lymphocytes/O ./O
The/O Mig1/I repressor/I is/O a/O zinc/I finger/I protein/I that/O mediates/O glucose/O repression/O in/O yeast/O ./O
Ethylene/O is/O involved/O in/O endosperm/O rupture/O and/O high/O -/O level/O betaGLU/I I/I expression/O ;/O but/O ,/O it/O does/O not/O affect/O the/O spatial/O and/O temporal/O pattern/O of/O betaGLU/I I/I expression/O ./O
The/O divergence/O in/O primary/O structure/O between/O the/O sheep/O CRF1/I and/O the/O other/O mammalian/I CRF1s/I is/O primarily/O localized/O to/O the/O extracellular/O amino/O terminal/O domain/O of/O the/O receptor/O (/O 18/O of/O 22/O divergent/O residues/O ,/O ovine/O vs/O human/I CRF1/I )./O
Agonist/O -/O induced/O receptor/O internalization/O ,/O determined/O as/O the/O percent/O of/O total/O [/O 125I/O ]/O Tyr0/I -/I oCRF/I bound/O located/O in/O the/O acid/O -/O resistant/O fraction/O of/O transfected/O Cos/O 7/O cells/O ,/O increased/O with/O time/O (/O 0/O -/O 60/O min/O at/O 37/O degrees/O C/O )/O for/O both/O wild/O -/O type/O and/O variant/O oCRF1/I ./O
Recurrent/O arterial/O thrombotic/O disease/O on/O young/O onset/O and/O protein/I S/I deficiency/O ./O
We/O showed/O that/O Stat3/I and/O Stat3beta/I were/O affinity/O purified/O using/O phosphopeptides/O containing/O Y704/O and/O Y744/O but/O not/O by/O nonphosphorylated/O peptide/O analogues/O or/O by/O phosphopeptides/O containing/O Y729/O and/O Y764/O ./O
Taken/O together/O ,/O our/O results/O indicate/O that/O the/O FCR1/I gene/I behaves/O as/O a/O negative/O regulator/O of/O drug/O resistance/O in/O C/O ./O albicans/O and/O constitute/O the/O first/O evidence/O that/O FCZ/O resistance/O can/O result/O from/O the/O inactivation/O of/O a/O regulatory/O factor/O such/O as/O Fcr1p/I ./O
These/O findings/O suggest/O that/O late/O MYO/O //O M/O is/O more/O useful/O than/O washout/O rate/O to/O assess/O the/O effect/O of/O treatment/O on/O heart/O failure/O due/O to/O DCM/O ./O
This/O study/O was/O undertaken/O to/O evaluate/O how/O couplers/O and/O their/O placement/O affect/O the/O ALGO2/O click/O spectral/O properties/O ./O
CONCLUSIONS/O :/O Pretreatment/O with/O OCs/O prior/O to/O pituitary/O suppression/O in/O the/O early/O follicular/O phase/O decreases/O ovarian/O cyst/O formation/O ,/O without/O an/O apparent/O effect/O on/O subsequent/O follicular/O recruitment/O or/O pregnancy/O rates/O ./O
With/O regard/O to/O the/O optimal/O threshold/O values/O ,/O sensitivity/O and/O specificity/O were/O 100/O %//O 97/O %/O and/O 95/O %//O 95/O %/O with/O FDG/O PET/O ,/O compared/O to/O 86/O %//O 92/O %/O and/O 77/O %//O 82/O %/O with/O IS/O ,/O respectively/O ./O
This/O c/I -/I Jun/I activity/O is/O inhibited/O by/O c/I -/I Fos/I ,/O another/O protooncoprotein/O that/O can/O dimerize/O with/O c/I -/I Jun/I to/O form/O the/O transcription/O factor/O AP/I -/I 1/I ./O
Dorsal/O root/O ganglia/O neuron/O -/O specific/O promoter/O activity/O of/O the/O rabbit/I beta/I -/I galactoside/I alpha1/I ,/I 2/I -/I fucosyltransferase/I gene/I ./O
CONCLUSION/O :/O Our/O study/O shows/O that/O (/O 1/O )/O total/O body/O BMD/O and/O femoral/O neck/O BMD/O were/O significantly/O higher/O in/O the/O study/O group/O that/O performed/O weight/O -/O bearing/O exercises/O than/O in/O control/O subjects/O ,/O (/O 2/O )/O swimming/O exercise/O had/O no/O effect/O on/O BMD/O ,/O and/O (/O 3/O )/O although/O swimming/O is/O not/O a/O bone/O -/O building/O exercise/O ,/O it/O can/O significantly/O improve/O shoulder/O ,/O back/O ,/O and/O grip/O muscle/O strength/O ./O
This/O suggests/O roles/O for/O both/O the/O CE1/O and/O CE2/O elements/O in/O regulating/O Hoxb1/I gene/I expression/O during/O development/O ./O
CAL/O gain/O amounted/O to/O 4/O ./O 2/O +/-/O 1/O ./O 3/O mm/O ,/O 60/O %/O of/O the/O defects/O showing/O CAL/O gain/O >/O or/O =/O 4/O mm/O ./O
Comparisons/O with/O other/O known/O germins/I and/O germin/I -/I like/I proteins/I indicate/O that/O these/O Arabidopsis/O GLP/I subfamilies/O are/O unique/O from/O wheat/O germin/I ./O
Lead/O fixation/O in/O dogs/O achieved/O with/O RF/O energy/O ./O
However/O ,/O there/O has/O not/O been/O any/O evidence/O of/O A/O ./O salmonicida/O infections/O ,/O specifically/O furunculosis/O ,/O associated/O with/O the/O fish/O in/O this/O loch/O ./O
Further/O ,/O we/O show/O that/O this/O EIA/I -/O inducible/O CBF/O //O cdc2/I is/O related/O to/O the/O CBF/I which/O was/O shown/O to/O activate/O the/O heat/I shock/I protein/I 70/I promoter/I ./O
The/O percutaneous/O absorption/O of/O clindamycin/O was/O studied/O in/O healthy/O male/O volunteers/O ,/O comparing/O two/O investigative/O clindamycin/O (%/O w/O //O v/O )//O tretinoin/O (/O 0/O ./O 025/O %/O w/O //O v/O )/O gels/O ,/O containing/O clindamycin/O phosphate/O ester/O and/O clindamycin/O HCl/O ,/O respectively/O ,/O relative/O to/O a/O clindamycin/O phosphate/O lotion/O (/O 1/O %/O clindamycin/O ;/O Dalacin/O T/O )./O
The/O BAL/O concentrations/O of/O the/O nine/O cytokines/O evaluated/O for/O the/O more/O and/O less/O affected/O lungs/O were/O compared/O :/O interleukin/I -/I 6/I (/O IL/I -/I 6/I ),/O IL/I -/I 8/I ,/O IL/I -/I 12/I ,/O tumor/I necrosis/I factor/I -/I alpha/I (/O TNF/I -/I alpha/I ),/O and/O interferon/I gamma/I (/O IFN/I -/I gamma/I )/O showed/O significant/O differences/O (/O p/O ranged/O between/O 0/O ./O
Phosphorylation/O analyses/O indicated/O that/O inhibition/O of/O ERK/I -/I 1/I //I 2/I decreased/O okadaic/O acid/O -/O elevated/O phosphorylation/O of/O JunD/I and/O FosB/I ./O
Two/O -/O way/O analysis/O of/O variance/O was/O used/O to/O determine/O whether/O composite/O knowledge/O score/O differed/O among/O patient/O groups/O ./O
The/O human/O pathogenic/O bacterium/O group/O A/O Streptococcus/O produces/O an/O extracellular/O cysteine/I protease/I [/O streptococcal/I pyrogenic/I exotoxin/I B/I (/O SpeB/I )]/O that/O is/O a/O critical/O virulence/O factor/O for/O invasive/O disease/O episodes/O ./O
The/O orbitofrontal/O ,/O cingulate/O ,/O and/O anteromedial/O part/O of/O the/O dorsal/O premotor/O areas/O were/O preferentially/O activated/O by/O the/O self/O -/O initiated/O hand/O movement/O task/O (/O SELF/O )./O
Improving/O the/O evidence/O base/O for/O anaesthesia/O ./O
Plasma/O CCK/I levels/O were/O determined/O at/O regular/O intervals/O ./O
The/O peroxisome/O biogenesis/O disorders/O (/O PBDs/O )/O are/O a/O set/O of/O lethal/O genetic/O diseases/O characterized/O by/O peroxisomal/O metabolic/O deficiencies/O ,/O multisystem/O abnormalities/O ,/O mental/O retardation/O ,/O and/O premature/O death/O ./O
The/O active/O site/O includes/O the/O acidic/O triad/O Asp53/O (/O the/O site/O of/O phosphorylation/O ),/O Asp10/O and/O Glu9/O ./O
Consistent/O with/O these/O findings/O ,/O relatively/O weak/O transcriptional/O silencing/O by/O the/O native/O VDR/I was/O observed/O using/O the/O osteopontin/I VDRE/O ./O
In/O PAV/O -/O 3/O ,/O the/O E1A/I region/I is/O located/O between/O 1/O ./O 5/O and/O 3/O ./O 8/O map/O units/O ./O
Six/O putative/O MDV/O genome/O products/O ,/O including/O one/O Rep/I and/O five/O non/O -/O Rep/I proteins/O ,/O show/O high/O (/O 70/O ./O 4/O -/O 90/O ./O 9/O %)/O amino/O acid/O identity/O to/O the/O corresponding/O six/O FBNYV/I proteins/I ,/O whereas/O two/O other/O Rep/I proteins/I encoded/O by/O MDV/I -/I C2/I and/O C3/I are/O 82/O ./O 3/O %/O and/O 73/O ./O 0/O %/O identical/O to/O those/O encoded/O by/O SCSV/I -/I C2/I and/O C6/I ,/O respectively/O ./O
MPO/I was/O labeled/O with/O 1/O mCi/O 125I/O by/O a/O technique/O of/O self/O -/O labeling/O in/O the/O presence/O of/O 10/O (-/O 4/O )/O M/O hydrogen/O peroxide/O ./O
It/O is/O related/O to/O a/O variety/O of/O mammalian/O Golgi/O -/O associated/O proteins/O and/O to/O the/O yeast/O Uso1p/I ,/O an/O essential/O protein/O involved/O in/O docking/O of/O endoplasmic/O reticulum/O -/O derived/O vesicles/O to/O the/O cis/O -/O Golgi/O ./O
The/O data/O indicate/O that/O Bmp2/I is/O directly/O regulated/O by/O retinoic/O acid/O -/O bound/O receptors/O and/O Sp1/I ./O
Both/O proteins/O were/O shown/O to/O be/O constitutively/O associated/O with/O tubulin/I ./O
HEED/I was/O found/O to/O bind/O to/O MA/I protein/I in/O vitro/O ,/O as/O efficiently/O as/O in/O vivo/O in/O yeast/O cells/O ./O
Fas/I -/O resistant/O DT/O -/O 40/O lymphoma/O B/O -/O cells/O rendered/O BTK/I -/O deficient/O through/O targeted/O disruption/O of/O the/O btk/I gene/I by/O homologous/O recombination/O knockout/O underwent/O apoptosis/O after/O Fas/I ligation/O ,/O but/O wild/O -/O type/O DT/O -/O 40/O cells/O or/O BTK/I -/O deficient/O DT/O -/O 40/O cells/O reconstituted/O with/O wild/I -/I type/I human/I btk/I gene/I did/O not/O ./O
A/O motif/O (/O TGATGTCA/O )/O which/O matches/O a/O CREB/I site/I and/O is/O similar/O to/O an/O AP/I -/I 1/I site/I is/O embedded/O within/O ER2/I ./O
Conventionally/O ,/O four/O nominal/O allotypic/O variants/O ,/O b4/O ,/O b5/O ,/O b6/O and/O b9/O have/O been/O shown/O to/O be/O co/O -/O dominantly/O expressed/O at/O the/O Ckappa1/I gene/I locus/I ./O
Therefore/O ,/O in/O order/O to/O search/O for/O the/O latent/O genes/O ,/O we/O used/O allotype/O -/O specific/O oligonucleotides/O for/O b5/O ,/O b6/O and/O b9/O to/O probe/O DNAs/O from/O both/O normal/O and/O T/O ./O brucei/O -/O infected/O rabbits/O by/O Southern/O blotting/O ./O
TRAF2/I is/O known/O to/O associate/O with/O TRADD/I ,/O and/O expression/O of/O a/O dominant/O -/O negative/O N/O -/O terminal/O deletion/O TRAF2/I mutant/I was/O found/O to/O partially/O inhibit/O LMP1/I -/O induced/O JNK/I activation/O in/O 293/O cells/O ./O
These/O data/O further/O define/O a/O role/O for/O TRADD/I and/O TRAF2/I in/O JNK/I activation/O and/O confirm/O that/O LMP1/I utilizes/O signalling/O mechanisms/O used/O by/O the/O TNF/I receptor/I //O CD40/I family/O to/O elicit/O its/O pleiotropic/O activities/O ./O
Epstein/I -/I Barr/I virus/I -/I encoded/I latent/I membrane/I protein/I 1/I activates/O the/O JNK/I pathway/O through/O its/O extreme/O C/O terminus/O via/O a/O mechanism/O involving/O TRADD/I and/O TRAF2/I ./O
In/O contrast/O ,/O transiently/O transfected/O cells/O expressing/O EBNA/I -/I 3/I revealed/O a/O sixfold/O increase/O in/O EBNA/I -/I 3/I protein/I expression/O from/O the/O genomic/O EBNA/I -/I 3/I gene/I compared/O to/O EBNA/I -/I 3/I cDNA/I ./O
However/O ,/O serial/O passages/O of/O fetal/O lamb/O kidney/O (/O FLK/O )/O cells/O ,/O which/O are/O sensitive/O to/O infection/O with/O BLV/O ,/O after/O transient/O transfection/O revealed/O that/O mutation/O of/O a/O second/O tyrosine/O residue/O in/O the/O N/O -/O terminal/O motif/O completely/O prevented/O the/O propagation/O of/O the/O virus/O ./O
Varicella/I -/I zoster/I virus/I (/I VZV/I )/I glycoprotein/I gI/I is/O a/O type/I 1/I transmembrane/I glycoprotein/I which/O is/O one/O component/O of/O the/O heterodimeric/O gE/I :/O gI/I Fc/I receptor/I complex/O ./O
To/O this/O end/O ,/O we/O analyzed/O the/O phosphorylation/O status/O of/O a/O universal/O tyrosine/I kinase/I substrate/O ,/O the/O transforming/O Shc/I adapter/I protein/I ,/O in/O fibroblasts/O expressing/O the/O viral/O oncogene/O ./O
These/O genes/O were/O expressed/O in/O a/O Saccharomyces/O cerevisiae/O mutant/O in/O which/O the/O endogenous/I ferrochelatase/I gene/I (/O HEM15/I )/O had/O been/O deleted/O ,/O and/O the/O phenotypes/O of/O the/O transformants/O were/O characterized/O ./O
In/O this/O study/O ,/O evidence/O is/O presented/O that/O temporally/O and/O spatially/O specific/O mef2/I expression/O is/O controlled/O by/O a/O complex/O array/O of/O cis/O -/O acting/O regulatory/O modules/O that/O are/O responsive/O to/O different/O genetic/O signals/O ./O
Furthermore/O ,/O using/O transgenic/O mouse/O technology/O we/O localized/O independent/O cis/O -/O regulatory/O elements/O controlling/O the/O tissue/O -/O specific/O expression/O of/O Pax6/I ./O
In/O the/O second/O experiment/O ,/O a/O stable/O nickel/O isotope/O ,/O 61Ni/O ,/O was/O given/O in/O drinking/O water/O to/O 20/O nickel/O -/O sensitized/O women/O and/O 20/O age/O -/O matched/O controls/O ,/O both/O groups/O having/O vesicular/O hand/O eczema/O of/O the/O pompholyx/O type/O ./O
Folded/O tissue/O and/O crimped/O collagen/I fibers/O in/O the/O tunica/O albuginea/O permit/O its/O expansion/O during/O erection/O ./O
Number/O of/O patients/O infected/O with/O nontuberculous/O mycobacteria/O (/O NTM/O )/O is/O increasing/O world/O -/O wide/O in/O recent/O years/O ./O
Comparison/O of/O the/O sequences/O of/O attP/I ,/O attB/I and/O bacteria/O -/O prophage/O junctions/O attL/I and/O attR/I showed/O a/O 26/O bp/O common/O core/O sequence/O ,/O where/O recombination/O takes/O place/O ,/O near/O the/O 5/O '/O end/O of/O the/O integrase/I gene/I ./O
Interferon/I -/I alpha/I treatment/O of/O posttransplant/O lymphoproliferative/O disorder/O in/O recipients/O of/O solid/O organ/O transplants/O ./O
Immunological/O testing/O was/O performed/O on/O all/O brewery/O workers/O and/O some/O control/O volunteers/O using/O skin/O prick/O testing/O with/O hops/O ,/O barley/O ,/O and/O yeast/O antigens/O as/O well/O as/O other/O nonoccupational/O allergens/O ,/O and/O by/O determining/O total/O serum/I IgE/I levels/O ./O
OBJECTIVE/O :/O To/O evaluate/O the/O accuracy/O of/O working/O casts/O for/O crown/O and/O bridge/O restorations/O made/O from/O twin/O mix/O putty/O //O wash/O silicone/O elastomeric/O impression/O materials/O using/O different/O types/O of/O stock/O tray/O ./O
OBJECTIVES/O :/O To/O assess/O the/O ability/O of/O pretreatment/O and/O post/O -/O treatment/O prostate/I -/I specific/I antigen/I (/O PSA/I )/O measurements/O ,/O clinical/O tumor/O stage/O ,/O tumor/O grade/O ,/O Gleason/O sum/O ,/O race/O ,/O age/O ,/O and/O radiation/O dose/O to/O predict/O the/O recurrence/O of/O prostate/O cancer/O following/O external/O beam/O radiation/O therapy/O (/O XRT/O )/O since/O the/O introduction/O of/O PSA/I as/O a/O tumor/O marker/O at/O one/O tertiary/O care/O center/O ./O
To/O evaluate/O whether/O the/O human/O gene/O is/O also/O a/O target/O of/O thyroid/O hormone/O we/O have/O searched/O for/O T3/O -/O responsive/O elements/O in/O NRGN/I cloned/O genomic/O fragments/O spanning/O the/O whole/O gene/O ./O
The/O transcriptional/O activity/O of/O PPARgamma/I is/O positively/O modulated/O by/O ligand/O binding/O and/O negatively/O regulated/O by/O phosphorylation/O mediated/O by/O the/O MEK/I //O ERK/I signaling/O pathway/O ./O
BACKGROUND/O :/O Diazepam/O ,/O one/O of/O the/O benzodiazepine/O group/O of/O tranquilizers/O ,/O is/O used/O as/O an/O adjunctive/O drug/O for/O sedation/O and/O for/O relief/O of/O anxiety/O in/O the/O treatment/O of/O epilepsy/O ./O
Bioplastique/O granuloma/O presents/O with/O irregularly/O shaped/O cystic/O spaces/O of/O varying/O size/O containing/O jagged/O ,/O translucent/O ,/O nonbirefringent/O foreign/O bodies/O whereas/O Artecoll/O granuloma/O shows/O numerous/O round/O vacuoles/O nearly/O identical/O in/O size/O and/O shape/O enclosing/O round/O and/O sharply/O circumscribed/O ,/O translucent/O ,/O nonbirefringent/O foreign/O bodies/O ./O
This/O Tbx6/I -/I subfamily/I gene/I is/O likely/O to/O participate/O in/O paraxial/O mesoderm/O formation/O and/O somitogenesis/O in/O human/O embryo/O ./O
Structure/O -/O function/O analysis/O of/O the/O Z/O -/O DNA/O -/O binding/O domain/O Zalpha/O of/O dsRNA/I adenosine/I deaminase/I type/I I/I reveals/O similarity/O to/O the/O (/I alpha/I +/I beta/I )/I family/I of/O helix/I -/I turn/I -/I helix/I proteins/I ./O
In/O addition/O ,/O the/O regulation/O of/O Glvr/I -/I 1/I gene/I expression/O also/O has/O potential/O applications/O to/O gene/O therapy/O ,/O since/O retroviral/O vectors/O carrying/O gibbon/I ape/I leukemia/I virus/I envelope/I proteins/I are/O used/O for/O gene/O delivery/O into/O different/O cell/O types/O ./O
Carbohydrates/O and/O glycoconjugates/O biophysical/O methods/O ./O
Molecular/O cloning/O of/O mouse/I glycolate/I oxidase/I ./O
In/O such/O a/O manner/O ,/O activated/O PKR/I inhibits/O cell/O growth/O and/O induces/O apoptosis/O ,/O whereas/O disruption/O of/O normal/O PKR/I signaling/O results/O in/O unregulated/O cell/O growth/O ./O
We/O isolated/O a/O ribosomal/I protein/I L18/I by/O interaction/O with/O PKR/I ./O
Processing/O of/O the/O polycistronic/O precursor/O requires/O nucleases/O also/O involved/O in/O rRNA/O processing/O ,/O i/O ./O e/O .,/O Rnt1p/I and/O Rat1p/I ./O
To/O search/O for/O transcriptional/O regulators/O ,/O we/O used/O a/O fragment/O of/O the/O SpHE/I promoter/I containing/O several/O individual/O elements/O instead/O of/O the/O conventional/O bait/O that/O contains/O a/O multimerized/O cis/O element/O ./O
As/O expected/O for/O a/O positive/O SpHE/I transcriptional/I regulator/I ,/O the/O timing/O of/O SpEts4/I gene/I expression/O precedes/O the/O transient/O expression/O of/O SpHE/I in/O the/O very/O early/O sea/O urchin/O blastula/O ./O
Furthermore/O ,/O rhoA/I -/O mediated/O SRE/O activation/O was/O blocked/O by/O dominant/O negative/O mutants/O of/O PKC/I -/I alpha/I or/O PKC/I -/I epsilon/I ./O
Nip7p/I -/O depleted/O cells/O exhibited/O the/O same/O defects/O as/O Nop8p/I -/O depleted/O cells/O ,/O except/O that/O they/O accumulated/O 27S/I precursors/I ./O
We/O show/O that/O the/O Sm/I -/I binding/I site/I and/O stem/O -/O loop/O III/O structures/O are/O necessary/O for/O correct/O 3/O '-/O end/O formation/O ./O
Five/O different/O subtypes/O of/O spondyloarthropathy/O (/O SpA/O )/O are/O now/O recognized/O ./O
Further/O experiments/O will/O be/O required/O to/O highlight/O the/O in/O vivo/O role/O of/O ELE1/I in/O nuclear/O receptor/O functioning/O ./O
Overexpression/O of/O PTTG/I in/O transfected/O NIH/O 3T3/O cells/O also/O stimulated/O expression/O and/O secretion/O of/O basic/I fibroblast/I growth/I factor/I ,/O a/O human/I pituitary/I tumor/I growth/I -/I regulating/I factor/I ./O
The/O perifascicular/O connective/O tissue/O sheath/O is/O important/O in/O organising/O the/O contraction/O of/O the/O myocardium/O by/O preventing/O lateral/O spread/O of/O conduction/O and/O by/O permitting/O transmission/O of/O the/O impulse/O only/O at/O the/O termination/O of/O the/O purkinje/O fibre/O ./O
E1/I ,/O a/O DNA/I helicase/I ,/O collaborates/O with/O the/O HPV/I E2/I protein/I in/O ori/O -/O dependent/O replication/O ./O
Here/O we/O describe/O a/O mutant/O alpha/O subunit/O designed/O to/O inhibit/O receptor/O -/O mediated/O hormonal/O activation/O of/O Gs/I ,/O the/O stimulatory/O regulator/O of/O adenylyl/I cyclase/I ./O
A/O gapped/O search/O with/O the/O C/O -/O terminal/O region/O of/O CDED/I //O LIOR/I revealed/O a/O 36/O -/O 41/O %/O similarity/O to/O several/O proteins/O related/O to/O signal/O transduction/O and/O cell/O replication/O ,/O such/O as/O ORC1/I and/O KSR/I ./O
Northern/O blot/O analysis/O demonstrated/O the/O ubiquitous/O expression/O of/O 2/O ./O 9/O kb/O and/O 3/O ./O
Additionally/O ,/O a/O variety/O of/O regulatory/O schemes/O contribute/O temporal/O and/O //O or/O spatial/O restriction/O to/O TGF/I -/I beta/I responses/O ./O
Induction/O of/O anaesthesia/O was/O standardised/O :/O fentanyl/O (/O 3/O micrograms/O //O kg/O ),/O thiopentone/O (/O 5/O mg/O //O kg/O ),/O atracurium/O (/O 0/O ./O 4/O mg/O //O kg/O )./O
A/O comparison/O of/O the/O clinical/O profile/O of/O cavernous/O malformations/O with/O and/O without/O associated/O venous/O malformations/O ./O
Conserved/O and/O distinct/O roles/O of/O kreisler/I in/O regulation/O of/O the/O paralogous/O Hoxa3/I and/O Hoxb3/I genes/I ./O
Magnetically/O induced/O optical/O self/O -/O pulsing/O in/O a/O nonlinear/O resonator/O ./O
Wave/O cybernetics/O :/O A/O simple/O model/O of/O wave/O -/O controlled/O nonlinear/O and/O nonlocal/O cooperative/O phenomena/O ./O
Autoionization/O rates/O and/O energy/O levels/O of/O triplet/O nf/O ,/O v/O =/O 1/O Rydberg/O states/O of/O H2/O ./O
Unitary/O -/O group/O approach/O to/O spin/O -/O dependent/O operators/O ./O
Nonlocal/O approach/O to/O scattering/O in/O a/O one/O -/O dimensional/O problem/O ./O
Soft/O -/O x/O -/O ray/O lasing/O at/O 32/O ./O 6/O nm/O in/O Ne/O -/O like/O Ti/O ions/O driven/O by/O 40/O J/O of/O energy/O from/O two/O 650/O -/O ps/O laser/O pulses/O ./O
Next/O ,/O to/O identify/O regions/O of/O the/O promoter/O involved/O ,/O we/O examined/O a/O series/O of/O tenascin/I -/I C/I promoter/I constructs/I with/O 5/O '/O deletions/O and/O showed/O that/O denatured/O collagen/I -/I dependent/I promoter/I activity/O was/O retained/O by/O a/O 122/O -/O base/O pair/O element/O ,/O located/O -/O 43/O to/O -/O 165/O bp/O upstream/O of/O the/O RNA/O start/O site/O ./O
Nuclear/I factor/I kappa/I B/I (/O NF/I -/I kappaB/I )/O is/O an/O important/O transcription/O factor/O for/O the/O genes/O of/O many/O pro/O -/O inflammatory/O proteins/O and/O is/O strongly/O activated/O by/O the/O cytokines/O interleukin/I -/I 1/I and/O tumor/I necrosis/I factor/I (/I TNF/I )/I alpha/I under/O various/O pathological/O conditions/O ./O
Moreover/O ,/O this/O enhancement/O of/O transcriptional/O activation/O by/O COUP/I -/I TFI/I requires/O specifically/O the/O AF/O -/O 1/O transactivation/O function/O of/O ER/I and/O can/O be/O observed/O in/O the/O presence/O of/O E2/O or/O 4/O -/O hydroxytamoxifen/O but/O not/O ICI/O 164384/O ./O
Recombinant/I Ffh/I has/O a/O melting/O point/O of/O tm/O =/O 89/O degreesC/O ./O
Unilateral/O naris/O occlusion/O and/O the/O rat/O accessory/O olfactory/O bulb/O ./O
This/O region/O of/O hsp90/I mediates/O ATP/O -/O independent/O chaperone/O activity/O ,/O overlaps/O the/O hsp90/I dimerization/I domain/I ,/O and/O includes/O structural/O elements/O important/O for/O steroid/I receptor/I interaction/O ./O
The/O promoter/O of/O the/O rat/O pgp2/I //O mdr1b/I gene/O has/O a/O GC/O -/O rich/O region/O (/O pgp2GC/I )/O that/O is/O highly/O conserved/O in/O mdr/I genes/I and/O contains/O an/O consensus/O Sp1/I site/I ./O
Sp1/I '/O s/O role/O in/O transactivation/O of/O the/O pgp2/I //O mdr1b/I promoter/O was/O tested/O in/O Drosophila/O Schneider/O cells/O ./O
Measurements/O included/O bone/O mineral/O density/O of/O the/O lumbar/O spine/O and/O proximal/O femur/O (/O by/O dual/O -/O energy/O X/O -/O ray/O absorptiometry/O )/O and/O biochemical/O markers/O of/O bone/O remodeling/O (/O serum/O bone/O -/O specific/O alkaline/I phosphatase/I by/O immunoassay/O and/O urine/O deoxypyridinoline/O by/O high/O -/O pressure/O liquid/O chromatography/O )./O
Human/I MGP/I is/O a/O 10/I -/I kD/I skeletal/I extracellular/I matrix/I (/I ECM/I )/I protein/I that/O consists/O of/O an/O 84/O -/O aa/O mature/O protein/O and/O a/O 19/O -/O aa/O transmembrane/O signal/O peptide/O ./O
Dual/O roles/O of/O p82/I ,/O the/O clam/O CPEB/I homolog/I ,/O in/O cytoplasmic/O polyadenylation/O and/O translational/O masking/O ./O
The/O RNA/I polymerase/I III/I -/I recruiting/I factor/I TFIIIB/I induces/O a/O DNA/O bend/O between/O the/O TATA/O box/O and/O the/O transcriptional/O start/O site/O ./O
The/O pattern/O of/O RNase/I E/I digestion/O of/O finP305/I RNA/I differed/O from/O FinP/I ,/O and/O GST/I -/O FinO/I did/O not/O protect/O finP305/I RNA/I from/O cleavage/O in/O vitro/O ./O
Transcription/O readthrough/O into/O the/O inverted/O repeats/O has/O little/O effect/O on/O this/O event/O ./O
Analysis/O of/O hematopoietic/I growth/I factor/I prescriptions/O in/O 19/O french/O cancer/O centers/O
In/O the/O second/O case/O ,/O an/O epidermal/O cyst/O was/O diagnosed/O ./O
MotA/I also/O binds/O a/O DNA/O sequence/O (/O a/O MotA/I box/I ),/O centered/O at/O position/O -/O 30/O ./O
We/O suggest/O that/O MotA/I and/O AsiA/I may/O function/O like/O certain/O eukaryotic/I TAFs/I (/O TATA/I binding/I protein/I (/I TBP/I )/I associated/I factors/I )/O whose/O binding/O to/O TBP/I results/O in/O transcription/O from/O new/O core/O promoter/O sequences/O ./O
The/O S229A/O variant/O can/O better/O flip/O modified/O bases/O but/O does/O not/O tightly/O lock/O the/O flipped/O base/O into/O the/O adenine/O -/O binding/O pocket/O ,/O suggesting/O that/O Ser229/O could/O form/O a/O contact/O to/O the/O flipped/O adenine/O ./O
The/O high/O conservation/O of/O the/O 3/O '/O terminus/O suggests/O that/O this/O region/O directs/O the/O assembly/O of/O proteins/O required/O for/O the/O initiation/O of/O RNA/O replication/O ./O
All/O stimulations/O were/O down/O -/O regulated/O with/O GnRH/I -/I a/I commenced/O on/O day/O 21/O in/O a/O long/O protocol/O before/O gonadotropin/I stimulation/O ./O
The/O sequence/O up/O to/O -/O 267/O bp/O relative/O to/O the/O transcription/O start/O site/O was/O sufficient/O to/O enhance/O reporter/O gene/O expression/O depending/O on/O the/O mesodermal/O differentiation/O of/O P19/O cells/O ./O
Chem/O ./O
No/O significant/O differences/O between/O the/O substituted/O and/O wild/O type/O peptides/O were/O observed/O ,/O suggesting/O that/O this/O substitution/O in/O the/O intact/O protein/O may/O cause/O disruption/O of/O global/O rather/O than/O local/O structures/O ./O
These/O results/O suggest/O that/O the/O c/I -/I met/I gene/I is/O also/O a/O target/O of/O p53/I gene/I regulation/O ./O
C3/I toxin/I completely/O inhibited/O RhoA/I function/O ,/O partially/O inhibited/O SRE/O :/O Luc/I activity/O ,/O but/O had/O no/O effect/O on/O LPA/O -/O stimulated/O c/I -/I Fos/I expression/O ./O
However/O ,/O C3/I toxin/I alone/O or/O in/O combination/O with/O growth/O factors/O did/O not/O stimulate/O AP/I -/I 1/I :/O Luc/I activity/O and/O actually/O antagonized/O the/O synergistic/O activation/O of/O AP/I -/I 1/I :/O Luc/I observed/O in/O response/O to/O co/O -/O stimulation/O with/O growth/O factors/O and/O Ro/O -/O 31/O -/O 8220/O ./O
The/O aim/O of/O the/O present/O study/O was/O to/O examine/O the/O antimicrobial/O susceptibility/O to/O 10/O currently/O used/O antimicrobial/O agents/O of/O 50/O strains/O of/O P/O ./O acnes/O isolated/O from/O acne/O lesions/O and/O identified/O using/O a/O Rap/O ID/O ANA/O II/O panel/O ./O
The/O role/O of/O intraoperative/O echocardiography/O in/O surgery/O of/O the/O heart/O and/O large/O vessels/O
Taken/O together/O ,/O our/O results/O demonstrate/O that/O CAP1/I is/O involved/O in/O multidrug/O resistance/O and/O oxidative/O stress/O response/O in/O C/O ./O albicans/O ./O
Trinipatch/O is/O a/O small/O ,/O transparent/O ,/O matricial/O ,/O monolayer/O patch/O with/O an/O absorption/O promoter/O ,/O marketed/O in/O two/O dose/O -/O strengths/O (/O 5/O mg/O //O 24/O h/O and/O 10/O mg/O //O 24/O h/O )/O by/O Laboratoires/O Synthelabo/O ./O
The/O RMRI/O was/O tested/O for/O interrater/O reliability/O using/O three/O simulated/O and/O 10/O actual/O patients/O ./O
The/O starting/O point/O is/O the/O consideration/O that/O the/O conceptions/O underlying/O the/O ICIDH/O are/O not/O suitable/O to/O serve/O as/O a/O mainstay/O of/O a/O model/O for/O diagnostics/O in/O rehabilitation/O because/O they/O do/O not/O reflect/O essential/O characteristics/O of/O the/O diagnostic/O process/O which/O is/O the/O basis/O for/O intervention/O ./O
Pokeweed/I antiviral/I protein/I (/O PAP/I )/O from/O Phytolacca/O americana/O is/O a/O highly/O specific/O N/I -/I glycosidase/I removing/O adenine/O residues/O (/O A4324/O in/O 28S/I rRNA/I and/O A2660/O in/O 23S/I rRNA/I )/O from/O intact/O ribosomes/O of/O both/O eukaryotes/O and/O prokaryotes/O ./O
OBJECTIVE/O :/O This/O meta/O -/O analysis/O of/O 67/O controlled/O trials/O was/O performed/O to/O quantify/O the/O cholesterol/O -/O lowering/O effect/O of/O major/O dietary/O fibers/O ./O
Among/O these/O 360/O ZFPs/I ,/O a/O novel/O ZFP/I cDNA/I named/O HFHZ/I (/O human/I fetal/I heart/I ZFP/I )/O with/O sequence/O homology/O to/O a/O Kruppel/I -/I associated/I box/I (/O KRAB/I )/O was/O identified/O ./O
The/O 3/O ./O 3/O -/O fold/O higher/O expression/O in/O the/O fetal/O heart/O than/O in/O the/O adult/O heart/O suggests/O that/O HFHZ/I mRNA/I is/O downregulated/O in/O the/O process/O of/O development/O ./O
When/O the/O high/O affinity/O hnRNP/I A1/I binding/I site/I was/O inserted/O into/O the/O beta/I -/I globin/I reporter/I ,/O Rev/I was/O able/O to/O increase/O the/O cytoplasmic/O levels/O of/O unspliced/O mRNAs/O to/O 14/O %./O
To/O date/O ,/O two/O such/O proteins/O ,/O PLZF/I and/O LAZ/I -/I 3/I //O BCL/I -/I 6/I ,/O have/O been/O implicated/O in/O oncogenesis/O ./O
Overexpression/O of/O POG1/I inhibits/O alpha/I -/I factor/I -/O induced/O G1/O arrest/O and/O transcriptional/O repression/O of/O the/O CLN1/I and/O CLN2/I genes/I ./O
We/O now/O show/O that/O RNU2/I fragility/O can/O be/O induced/O by/O transfection/O with/O an/O expression/O vector/O encoding/O Ad12/I E1B/I 55/O kDa/O alone/O but/O not/O by/O an/O E1/I vector/O encoding/O all/O E1/I products/I (/O 3/O E1A/I proteins/I ,/O as/O well/O as/O the/O E1B/I 19/O kDa/O and/O 55/O kDa/O proteins/O )./O
Competitionsupershift/O EMSA/O assays/O revealed/O that/O multiple/O proteins/O were/O involved/O in/O bandshift/O complex/O formation/O with/O KCS/I ,/O one/O of/O which/O was/O identified/O as/O factor/O Sp1/O ./O
Similarity/O of/O DNA/O binding/O and/O transcriptional/O regulation/O by/O Caenorhabditis/I elegans/I MAB/I -/I 3/I and/O Drosophila/I melanogaster/I DSX/I suggests/O conservation/O of/O sex/O determining/O mechanisms/O ./O
CONTEXT/O :/O ThinPrep/O ,/O AutoPap/O ,/O and/O Papnet/O are/O 3/O new/O technologies/O that/O increase/O the/O sensitivity/O and/O cost/O of/O cervical/O cancer/O screening/O ./O
Experiments/O on/O narcotized/O cats/O demonstrated/O that/O the/O derivatives/O of/O 2/O -/O mercaptobenzimidazole/O possessing/O the/O properties/O of/O specific/O bradycardic/O agents/O and/O coded/O as/O CM/O -/O 251/O ,/O CM/O -/O 266/O ,/O and/O CM/O -/O 345/O ,/O reduce/O the/O mean/O rise/O of/O segment/O ST/O on/O numerous/O leads/O of/O the/O epicardial/O electrogram/O during/O 5/O -/O min/O occlusion/O of/O the/O anterior/O descending/O branch/O of/O the/O left/O coronary/O artery/O ./O
Neither/O the/O p42/I //I 44/I nor/O the/O JNK/I pathway/O was/O involved/O in/O the/O action/O of/O IL/I -/I 1beta/I ./O
In/O protocol/O 2/O ,/O eight/O different/O subjects/O performed/O Con/O and/O Ecc/O arm/O curls/O to/O fatigue/O ,/O followed/O by/O postexercise/O muscle/O ischemia/O ,/O by/O using/O the/O same/O resistance/O as/O in/O protocol/O 1/O ./O
Airflow/O was/O measured/O with/O a/O custom/O -/O designed/O turbine/O and/O a/O 45/O -/O ft/O .-/O long/O cable/O to/O reach/O the/O volume/O -/O measuring/O module/O ./O
Both/O mutations/O confer/O amino/O acid/O substitutions/O in/O the/O viral/I coat/I protein/I but/O differ/O in/O their/O relative/O abilities/O to/O utilize/O the/O foreign/O scaffolding/I protein/I ./O
Complete/O recovery/O of/O liver/O function/O after/O this/O surgery/O tended/O to/O be/O slow/O ./O
Although/O both/O transcripts/O share/O the/O first/O nine/O exons/O ,/O exon/O 10/O of/O ZIS/I -/I 2/I is/O lacking/O in/O ZIS/I -/I 1/I ,/O and/O instead/O ,/O exon/O 11/O (/O 10th/O exon/O )/O of/O ZIS/I -/I 1/I is/O larger/O in/O size/O ,/O leading/O to/O the/O longer/O 3/O '-/O UTR/O ./O
Expression/O of/O the/O second/O gene/O (/O XT3/I )/O was/O found/O to/O be/O conserved/O in/O human/O kidney/O ,/O and/O partial/O sequence/O was/O obtained/O from/O a/O human/O cDNA/O library/O ./O
IFN/I -/I gamma/I was/O elevated/O during/O active/O TB/O when/O compared/O with/O healthy/O controls/O ,/O declining/O during/O and/O after/O treatment/O ./O
The/O missing/O 5/O '/O sequences/O were/O obtained/O by/O 5/O '-/O rapid/O amplification/O of/O cDNA/O ends/O and/O by/O analysis/O of/O an/O NHE5/I genomic/I clone/I ,/O and/O the/O missing/O 3/O '/O sequences/O were/O obtained/O by/O 3/O '-/O rapid/O amplification/O of/O cDNA/O ends/O ./O
If/O no/O alloantibodies/O are/O detected/O ,/O further/O analysis/O to/O define/O a/O role/O of/O drug/O -/O related/O or/O autoantibodies/O is/O required/O ./O
This/O dependence/O ,/O however/O ,/O can/O be/O overcome/O to/O a/O large/O extent/O by/O dividing/O min/O LVdP/O //O dt/O by/O mean/O aortic/O pressure/O ./O
Genoa/O ,/O Italy/O ,/O 24/O -/O 28/O August/O 1997/O ./O
Electronic/O structure/O of/O delta/O -/O plutonium/O and/O of/O single/O Al/O ,/O Ga/O ,/O and/O Sc/O impurities/O in/O delta/O -/O plutonium/O ./O
Bound/O -/O exciton/O transfer/O and/O photoluminescence/O undulation/O spectra/O for/O acceptors/O in/O ZnTe/O ./O
Unified/O theory/O of/O segregated/O -/O stack/O organic/O charge/O -/O transfer/O solids/O :/O Magnetic/O properties/O ./O
Internal/O modes/O of/O a/O soliton/O ./O
II/O ./O
Envelope/O -/O function/O matching/O conditions/O for/O GaAs/O /(/O Al/O ,/O Ga/O )/O As/O heterojunctions/O ./O
Neutron/O scattering/O measurements/O of/O critical/O exponents/O in/O CsMnBr3/O :/O A/O Z2/O &/O gt/O ;=/O 1/O antiferromagnet/O ./O
(/O 2/O )/O Erythroid/O 32D/O Epo1/I cells/O showed/O a/O lower/O level/O of/O bulk/O PKC/I catalytic/O activity/O ,/O lacked/O the/O expression/O of/O epsilon/I and/I eta/I PKC/I isoforms/I ,/O and/O showed/O a/O weak/O or/O absent/O upregulation/O of/O the/O remaining/O isoforms/O ,/O except/O betaI/I ,/O upon/O readdition/O of/O Epo/I to/O growth/O factor/O -/O starved/O cells/O ./O
We/O used/O expression/O cloning/O to/O identify/O interleukin/I -/I 6/I (/O IL/I -/I 6/I )/O as/O one/O factor/O that/O suppressed/O growth/O of/O a/O pre/O -/O B/O -/O cell/O variant/O line/O ,/O 1A9/O -/O M/O ./O
Airflow/O through/O the/O dust/O trap/O was/O controlled/O with/O a/O vacuum/O pump/O ./O
Thus/O ,/O in/O normal/O intestinal/O epithelial/O goblet/O cells/O ,/O TbetaRI/I and/O TbetaRII/I can/O respond/O to/O autocrine/O but/O not/O exogenous/O TGF/I -/I beta/I without/O the/O participation/O of/O TbetaRIII/I ./O
The/O history/O of/O exposure/O and/O carboxyhemoglobin/I levels/O should/O alert/O the/O physician/O to/O this/O diagnosis/O ./O
The/O odds/O ratio/O for/O CHD/O was/O 1/O ./O 21/O (/O 95/O %/O confidence/O interval/O ,/O 0/O ./O 84/O -/O 1/O ./O 75/O )/O given/O a/O positive/O serostatus/O of/O specific/O IgG/I antibodies/O after/O adjustment/O for/O covariates/O ./O
Another/O group/O of/O HIPP/O -/O and/O HCX/O -/O lesioned/O animals/O trained/O on/O the/O tasks/O after/O the/O lesion/O showed/O reduced/O impairments/O of/O the/O type/O described/O above/O ,/O suggesting/O that/O extrahippocampal/O structures/O trained/O after/O the/O lesion/O can/O assume/O the/O role/O of/O the/O hippocampus/O to/O some/O degree/O ./O
The/O case/O for/O neutrinos/O from/O SN/O 1987A/O ./O
Scaling/O of/O fluctuations/O in/O one/O -/O dimensional/O interface/O and/O hopping/O models/O ./O
Model/O of/O spatiotemporal/O dynamics/O of/O stick/O -/O slip/O motion/O ./O
NMR/O of/O diffusing/O atoms/O in/O a/O periodic/O porous/O medium/O in/O the/O presence/O of/O a/O nonuniform/O magnetic/O field/O ./O
Microstructure/O and/O conductivity/O of/O hierarchical/O laminate/O composites/O ./O
Anisotropic/O heat/O transport/O in/O the/O octylcyanobiphenyl/O (/O 8CB/O )/O liquid/O crystal/O ./O
Direct/O approach/O to/O the/O study/O of/O soliton/O perturbations/O ./O
Mutations/O affecting/O only/O CD4/I regulation/O mapped/O to/O residues/O previously/O shown/O to/O mediate/O the/O binding/O of/O Nef/I to/O this/O receptor/O ,/O such/O as/O W57/O and/O L58/O ,/O as/O well/O as/O to/O an/O AP/I -/I recruiting/I dileucine/I motif/I and/O to/O an/O acidic/O dipeptide/O in/O the/O C/O -/O terminal/O region/O of/O the/O protein/O ./O
Several/O mutations/O disrupted/O the/O endonuclease/O and/O helicase/I activities/O ;/O however/O ,/O only/O one/O amino/I -/I terminal/I -/I charge/I cluster/I mutant/I protein/I (/O D40A/O -/O D42A/O -/O D44A/O )/O completely/O lost/O AAV/O hairpin/O DNA/O binding/O activity/O ./O
The/O lytic/O cycle/O of/O KSHV/O ,/O probably/O under/O the/O initial/O control/O of/O the/O KSHV/I //I Rta/I gene/I ,/O may/O directly/O contribute/O to/O tumor/O pathogenesis/O ./O
We/O conclude/O that/O (/O i/O )/O we/O have/O identified/O several/O candidate/O latency/O genes/O of/O murine/O gammaHV68/O ,/O (/O ii/O )/O expression/O of/O genes/O during/O latency/O may/O be/O different/O in/O different/O organs/O ,/O consistent/O with/O multiple/O latency/O programs/O and/O //O or/O multiple/O cellular/O sites/O of/O latency/O ,/O and/O (/O iii/O )/O regions/O of/O the/O viral/O genome/O (/O v/I -/I bcl/I -/I 2/I gene/I ,/O v/I -/I GCR/I gene/I ,/O and/O gene/I 73/I )/O are/O transcribed/O during/O latency/O with/O both/O gammaHV68/O and/O primate/O gammaherpesviruses/O ./O
These/O data/O indicate/O a/O functional/O role/O for/O U1/I in/O NRS/I -/O mediated/O splicing/O inhibition/O ./O
This/O suggests/O that/O the/O DcuS/I -/O DcuR/I system/O responds/O to/O external/O substrates/O ./O
Here/O we/O describe/O the/O identification/O and/O characterization/O of/O several/O Sp100/I splice/I variant/I proteins/I and/O support/O their/O existence/O by/O elucidation/O of/O the/O 3/O '-/O end/O of/O the/O Sp100/I gene/I ./O
Crossover/O in/O the/O specific/O heat/O of/O dilute/O magnets/O induced/O by/O critical/O spin/O -/O wave/O dynamics/O ./O
Erratum/O :/O Absence/O of/O precursor/O effects/O above/O the/O martensitic/O transformation/O in/O a/O virgin/O crystal/O of/O Li/O metal/O
Interplane/O coupling/O in/O the/O superconductor/O Y2Ba4Cu7O15/O as/O revealed/O by/O NQR/O spin/O -/O echo/O double/O resonance/O ./O
Electronic/O structure/O of/O a/O buried/O NiSi2/O or/O CoSi2/O layer/O in/O bulk/O Si/O ./O
Raman/O investigation/O of/O YBa2/O -/O xLaxCu3O7/O ceramics/O ./O
Effects/O of/O point/O defects/O on/O lattice/O parameters/O of/O semiconductors/O ./O
Chaotic/O electron/O dynamics/O around/O a/O single/O elliptically/O shaped/O antidot/O ./O
However/O ,/O deletions/O of/O the/O C/O terminal/O 11/O or/O 14/O amino/O acids/O had/O more/O substantial/O effects/O ./O
Sixty/O months/O after/O the/O initial/O vaccination/O ,/O all/O vaccinees/O who/O received/O annual/O follow/O -/O up/O still/O had/O protective/O levels/O of/O anti/I -/I HAV/I ./O
However/O ,/O after/O PRK/O at/O 5/O weeks/O of/O age/O ,/O partial/O retreatment/O may/O be/O necessary/O due/O to/O regression/O of/O the/O PRK/O effect/O ./O
Its/O early/O lesions/O were/O characterized/O by/O angiomatosis/O ,/O vasculopathy/O ,/O and/O proliferation/O of/O synoviocytes/O and/O fibroblasts/O ./O
Molecular/O cloning/O of/O human/O cDNA/O encoding/O a/O novel/O beta1/I ,/I 6/I -/I N/I -/I acetylglucosaminyltransferase/I forming/O core/O 2/O and/O core/O 4/O ./O
Interspecific/O mouse/O back/O -/O cross/O analysis/O identified/O the/O loci/O for/O mouse/I 3Ost/I genes/I and/O syntenic/O assignments/O of/O corresponding/O human/O isologs/O were/O confirmed/O by/O the/O identification/O of/O mapped/O sequence/O -/O tagged/O site/O markers/O ./O
The/O Scales/O of/O Cognitive/O Impairment/O Rated/O From/O Institutional/O Records/O (/O SCIRFIR/O ),/O a/O battery/O based/O on/O commonly/O used/O dementia/O rating/O instruments/O ,/O was/O tested/O on/O the/O records/O of/O 26/O chronically/O institutionalized/O ,/O elderly/O schizophrenia/O patients/O ,/O for/O the/O purpose/O of/O retrospectively/O evaluating/O the/O long/O -/O term/O course/O of/O cognitive/O change/O in/O schizophrenia/O and/O relating/O it/O to/O available/O autopsy/O materials/O ./O
It/O was/O demonstrated/O that/O the/O processing/O signals/O in/O the/O transcript/O ,/O i/O ./O e/O ./O both/O donor/O splice/O sites/O and/O the/O polyadenylation/O site/O located/O in/O the/O muscle/O -/O specific/O intron/O ,/O have/O to/O be/O weak/O ./O
Most/O recently/O ,/O the/O use/O of/O the/O product/O of/O brain/O weight/O and/O clearance/O has/O been/O proposed/O ./O
Recombination/O and/O transcription/O of/O the/O endogenous/I Ig/I heavy/I chain/I locus/I is/O effected/O by/O the/O Ig/I heavy/I chain/I intronic/I enhancer/I core/I region/I in/O the/O absence/O of/O the/O matrix/O attachment/O regions/O ./O
Two/O of/O these/O motifs/O are/O part/O of/O a/O highly/O conserved/O and/O inducible/O dyad/O symmetry/O element/O shown/O previously/O to/O control/O a/O remote/O IL/I -/I 2/I enhancer/I and/O the/O CD18/I promoter/I ./O
In/O concert/O with/O the/O coactivator/O CREB/I binding/I protein/I //O p300/I ,/O which/O interacts/O with/O GABPalpha/I ,/O the/O binding/O of/O GABPalpha/I and/I -/I beta/I to/O the/O dyad/O symmetry/O element/O controls/O the/O induction/O of/O IL/I -/I 16/I promoter/I in/O T/O cells/O ./O
TPO/I by/O itself/O did/O not/O activate/O ERK1/I ,/O ERK2/I and/O protein/I kinase/I C/I (/O PKC/I ),/O whereas/O TPO/I directly/O enhanced/O the/O PKC/I -/O dependent/O activation/O of/O ERKs/I induced/O by/O other/O agonists/O including/O thrombin/I and/O phorbol/O esters/O ,/O without/O affecting/O the/O PKC/I activation/O by/O those/O agonists/O ./O
BACKGROUND/O :/O In/O the/O ubiquitin/I -/O dependent/O proteolysis/O pathway/O ,/O a/O ubiquitin/I ligase/I (/O E3/I )/O is/O responsible/O for/O substrate/O selectivity/O and/O timing/O of/O degradation/O ./O
CONCLUSIONS/O :/O Fission/I yeast/I SCF/I is/O composed/O of/O Pop1/I and/O Pop2/I ,/O two/O structurally/O related/O but/O functionally/O independent/O F/I -/I box/I //I WD/I -/I repeat/I proteins/I ./O
19F/O NMR/O studies/O in/O ABF4/O -/O type/O layered/O antiferromagnets/O ./O
Optical/O -/O absorption/O spectra/O ,/O crystal/O -/O field/O energy/O levels/O ,/O and/O transition/O line/O strengths/O of/O holmium/O in/O trigonal/O Na3/O
Observation/O of/O dipolar/O interactions/O between/O Pb0/O defects/O at/O the/O (/O 111/O )/O Si/O //O SiO2/O interface/O ./O
Quantum/O -/O statistical/O theory/O of/O high/O -/O field/O transport/O phenomena/O ./O
NH3/O and/O NO/O interaction/O with/O Si/O (/O 100/O )-(/O 2/O x/O 1/O )/O surfaces/O ./O
Chirality/O -/O glass/O and/O spin/O -/O glass/O correlations/O in/O the/O two/O -/O dimensional/O random/O -/O bond/O XY/O model/O ./O
Echo/O modulation/O in/O Pr3/O +:/O YAlO3/O ./O
Mechanisms/O of/O visible/O -/O light/O emission/O from/O electro/O -/O oxidized/O porous/O silicon/O ./O
Far/O -/O infrared/O hopping/O conductivity/O in/O the/O CuO/O chains/O of/O a/O single/O -/O domain/O YBa2Cu3O7/O -/O delta/O crystal/O ./O
Surface/O spin/O waves/O in/O a/O Heisenberg/O ferrimagnet/O with/O a/O single/O -/O ion/O anisotropy/O (/O uniaxial/O and/O nonuniaxial/O )./O
Optically/O detected/O librons/O and/O phonons/O in/O crystalline/O C60/O ./O
Multilayer/O -/O relaxation/O geometry/O and/O electronic/O structure/O of/O a/O W/O (/O 111/O )/O surface/O ./O
Temperature/O dependence/O of/O the/O sublattice/O spontaneous/O magnetization/O of/O YBa2Cu3O6/O ./O
GW/O Gamma/O approximation/O for/O electron/O self/O -/O energies/O in/O semiconductors/O and/O insulators/O ./O
Precision/O measurement/O of/O the/O pion/O mass/O difference/O m/O pi/O --/O m/O pi/O 0/O ./O
Testing/O gravity/O to/O second/O post/O -/O Newtonian/O order/O :/O A/O field/O -/O theory/O approach/O ./O
Genetic/O experiments/O using/O mutants/O defective/O in/O apontic/I and/O bruno/I reveal/O a/O functional/O interaction/O between/O these/O genes/O ./O
In/O the/O current/O model/O ,/O Wingless/I //O Wnt/I signal/O stabilizes/O Armadillo/I //O beta/I -/I catenin/I ,/O which/O then/O accumulates/O in/O nuclei/O and/O binds/O TCF/I //O LEF/I family/O proteins/O ,/O forming/O bipartite/O transcription/O factors/O which/O activate/O transcription/O of/O Wingless/I //O Wnt/I responsive/O genes/O ./O
In/O support/O of/O clinical/O antianginal/O studies/O ,/O the/O vasodilator/O nicorandil/O (/O NIC/O )/O was/O combined/O with/O the/O beta/I -/I adrenergic/I receptor/I antagonists/O propranolol/O (/O PRO/O )/O and/O atenolol/O (/O ATN/O )/O and/O with/O the/O calcium/O channel/O blocker/O diltiazem/O (/O DTZ/O )/O to/O determine/O their/O cardiovascular/O and/O pharmacokinetic/O interactions/O ./O
Factors/O influencing/O direct/O -/O immersion/O (/O DI/O )-/O SPME/O process/O were/O also/O checked/O and/O chosen/O experimentally/O ./O
In/O contrast/O ,/O an/O amino/O -/O terminal/O fragment/O containing/O the/O C/O //O H1/O domain/O was/O sufficient/O for/O coactivation/O of/O Zta/I transcription/O and/O viral/O reactivation/O function/O ./O
In/O addition/O ,/O a/O potent/O splicing/O enhancer/O sequence/O isolated/O in/O the/O selection/O specifically/O binds/O a/O 20/I -/I kDa/I SR/I protein/I ./O
Elimination/O of/O ETH1/I in/O apn1/I strains/O also/O increased/O spontaneous/O mutation/O rates/O 9/O -/O or/O 31/O -/O fold/O compared/O to/O the/O wild/O type/O as/O determined/O by/O reversion/O to/O adenine/O or/O lysine/O prototrophy/O ,/O respectively/O ./O
Elimination/O of/O ETH1/I in/O apn1/I strains/O also/O increased/O spontaneous/O mutation/O rates/O 9/O -/O or/O 31/O -/O fold/O compared/O to/O the/O wild/O type/O as/O determined/O by/O reversion/O to/O adenine/O or/O lysine/O prototrophy/O ,/O respectively/O ./O
These/O data/O suggest/O that/O other/O Ras/I effectors/I can/O collaborate/O with/O PI/I 3/I -/I kinase/I and/O with/O each/O other/O to/O activate/O Pak/I ./O
Mammalian/O Ras/I GTPase/I -/I activating/I protein/I (/O GAP/I ),/O p120/I Ras/I -/O GAP/I ,/O has/O been/O implicated/O as/O both/O a/O downregulator/O and/O effector/O of/O Ras/I proteins/I ,/O but/O its/O precise/O role/O in/O Ras/I -/O mediated/O signal/O transduction/O pathways/O is/O unclear/O ./O
Three/O mog/I -/I 1/I alleles/I possess/O premature/O stop/O codons/O and/O are/O likely/O to/O be/O null/O alleles/O ,/O and/O one/O is/O a/O missense/O mutation/O and/O is/O likely/O to/O retain/O residual/O activity/O ./O mog/I -/I 1/I mRNA/I is/O expressed/O in/O both/O germ/O line/O and/O somatic/O tissues/O and/O appears/O to/O be/O ubiquitous/O ./O
However/O ,/O unlike/O the/O SIN3/I gene/I of/O Saccharomyces/O cerevisiae/O ,/O pst1/I (+)/I is/O essential/O for/O cell/O viability/O ./O
The/O Nmd3/I protein/I sequence/I does/O not/O contain/O readily/O recognizable/O motifs/O of/O known/O function/O ./O
The/O distribution/O of/O the/O various/O repeats/O suggests/O its/O organization/O is/O similar/O to/O the/O beta/O -/O heterochromatic/O regions/O near/O the/O base/O of/O the/O major/O chromosome/O arms/O ./O
Calcitonin/I simultaneously/O regulates/O both/O periosteal/O hyperostosis/O and/O trabecular/O osteopenia/O in/O the/O spinal/O hyperostotic/O mouse/O (/O twy/I //O twy/I )/O in/O vivo/O ./O
Electrophoretic/O mobility/O -/O shift/O assays/O performed/O with/O the/O HNF/I -/I 3/I X/O and/O Y/O sites/O demonstrated/O that/O both/O sites/O are/O capable/O of/O binding/O HNF/I -/I 3alpha/I and/O HNF/I -/I 3beta/I ./O
In/O addition/O ,/O we/O also/O show/O that/O cdk7/I may/O phosphorylate/O the/O carboxy/O -/O terminal/O domain/O (/O CTD/O )/O of/O RNA/I pol/I II/I in/O the/O absence/O of/O promoter/O opening/O ./O
The/O therapy/O with/O a/O H2/I -/I receptor/I antagonist/O is/O less/O effective/O than/O the/O triple/O therapies/O with/O omeprazole/O or/O lansoprazole/O ./O
In/O humans/O ,/O three/O tissue/I -/I specific/I plastin/I isoforms/I have/O been/O identified/O ./O
No/O TATA/O or/O Inr/O sequence/O was/O found/O ./O
The/O inhibition/O by/O the/O RIalpha/I subunit/I is/O reversed/O by/O addition/O of/O nanomolar/O concentrations/O of/O cAMP/O (/O Ka/O =/O 40/O nM/O ),/O thus/O demonstrating/O that/O PrKX/I is/O a/O novel/O ,/O type/I I/I cAMP/I -/I dependent/I protein/I kinase/I that/O is/O activated/O at/O lower/O cAMP/O concentrations/O than/O the/O holoenzyme/O with/O the/O Calpha/I subunit/I of/O cAMP/I -/I dependent/I protein/I kinase/I ./O
Proteins/O known/O to/O bind/O the/O PEPCK/I CRE/O include/O the/O CRE/I -/I binding/I protein/I (/O CREB/I )/O and/O members/O of/O the/O CCAAT/I //I enhancer/I -/I binding/I protein/I (/O C/I //I EBP/I )/O family/O ./O
This/O construct/O ,/O termed/O pDeltaCREC/I //O EBP/I ,/O binds/O C/I //I EBPalpha/I and/I beta/I but/O not/O CREB/I ,/O yet/O it/O confers/O a/O nearly/O complete/O glucocorticoid/O response/O when/O transiently/O transfected/O into/O H4IIE/O rat/O hepatoma/O cells/O ./O
In/O addition/O ,/O in/O vitro/O mutagenesis/O of/O both/O Engrailed/I and/O Pbx1/I sites/I indicated/O that/O other/O unidentified/O sites/O are/O responsible/O for/O the/O transcriptional/O enhancement/O observed/O with/O the/O intronic/O fragment/O ./O
Several/O secondary/O structure/O elements/O were/O identified/O ./O
Here/O ,/O we/O evidence/O that/O the/O developmental/O functions/O of/O the/O family/O of/O transcription/O factors/O characterized/O by/O the/O POU/I DNA/I binding/I motif/I exerts/O roles/O in/O mammalian/O development/O ./O
High/O -/O affinity/O site/O -/O specific/O DNA/O binding/O by/O POU/I domain/I transcription/I factors/I requires/O both/O the/O POU/I -/I specific/I and/O the/O POU/I -/I homeodomain/I ./O
In/O the/O Oct/I -/I 1/I crystal/O ,/O the/O POU/I -/I specific/I domain/I recognizes/O a/O GCAT/O half/O -/O site/O ,/O while/O the/O corresponding/O sequence/O recognized/O by/O the/O Pit/I -/I 1/I POU/I -/O specific/O domain/O ,/O GTAT/O ,/O is/O on/O the/O opposing/O strand/O ./O
Systematic/O functional/O analysis/O of/O V1a/I //I V2/I hybrid/I receptors/I showed/O that/O the/O second/O intracellular/O loop/O of/O the/O V1a/I receptor/I is/O required/O and/O sufficient/O for/O efficient/O coupling/O to/O Gq/I //I 11/I ,/O whereas/O the/O third/O intracellular/O loop/O of/O the/O V2/I receptor/I is/O required/O and/O sufficient/O for/O coupling/O to/O Gs/I ./O
Most/O other/O end/O points/O were/O highly/O significant/O ,/O and/O death/O ,/O which/O was/O monitored/O across/O the/O U/O ./O S/O ./O program/O ,/O was/O different/O with/O p/O /O 37/O %)/O disclosed/O not/O only/O a/O higher/O n/O (/O mit/O )/O (/O 0/O ./O 63/O +/-/O 0/O ./O 17/O versus/O 0/O ./O 43/O +/-/O 0/O ./O 07/O mt/O x/O microm/O (-/O 2/O ),/O p/O /O 30/O mg/O //O 24/O h/O (/O n/O =/O 3/O with/O microalbuminuria/O ),/O whereas/O all/O the/O 17/O placebo/O -/O treated/O patients/O had/O normal/O UAER/O (/O 90/O %./O
Using/O an/O RNase/I H/I protection/O assay/O and/O specific/O blocking/O oligonucleotides/O ,/O we/O find/O that/O recognition/O of/O the/O 5/O '/O splice/O -/O site/O (/O 5/O '/O ss/O )/O and/O branchpoint/O sequence/O (/O BPS/O )/O elements/O by/O U11/I and/O U12/I snRNPs/I ,/O respectively/O ,/O displays/O strong/O cooperativity/O ,/O requiring/O both/O sites/O in/O the/O pre/O -/O mRNA/O substrate/O for/O efficient/O complex/O formation/O ./O
Analysis/O of/O lacZ/I transcriptional/I fusions/I shows/O that/O the/O KdgR/I -/I binding/I sites/I negatively/O affect/O the/O expression/O of/O rsmB/I ./O
Many/O eukaryotic/O cell/O surface/O proteins/O are/O anchored/O in/O the/O lipid/O bilayer/O through/O glycosylphosphatidylinositol/O (/O GPI/O )./O
In/O the/O cell/O -/O free/O import/O assay/O ,/O beta/I -/I catenin/I rapidly/O migrates/O into/O the/O nucleus/O without/O the/O exogenous/O addition/O of/O cytosol/O ,/O Ran/I ,/O or/O ATP/O //O GTP/O ./O
In/O ischemic/O and/O hypoxic/O hypoxia/O ,/O a/O strong/O correlation/O was/O found/O between/O cyt/O a/O ,/O a3/O oxidation/O level/O and/O VO2/O in/O both/O ischemic/O and/O hypoxic/O hypoxia/O (/O r2/O =./O 90/O and/O ./O 87/O ,/O respectively/O )./O
An/O endogenous/O mammalian/O regulator/O of/O this/O process/O ,/O named/O Usurpin/I ,/O has/O been/O identified/O (/O aliases/O for/O Usurpin/I include/O CASH/I ,/O Casper/I ,/O CLARP/I ,/O FLAME/I -/I 1/I ,/O FLIP/I ,/O I/I -/I FLICE/I and/O MRIT/I )./O
Plasma/O glucose/O ,/O immunoreactive/I insulin/I (/O IRI/I ),/O C/I -/I peptide/I ,/O glucagon/I ,/O and/O GLP/I -/I 1/I levels/O at/O each/O time/O point/O during/O OGTT/O were/O measured/O ./O
Each/O recombinant/O product/O was/O a/O fusion/O protein/O with/O a/O B/O domain/O of/O Staphylococcal/I protein/I A/I (/O SPA/I )./O
Polypyrimidine/O and/O ssDNA/O binding/O by/O the/O isolated/O VH/I domain/I of/O immunization/O -/O induced/O anti/O -/O Z/O -/O DNA/O Ab/O resembles/O the/O activity/O of/O natural/O autoantibodies/O and/O suggests/O that/O VH/I -/O dependent/O binding/O to/O a/O ligand/O mimicked/O by/O polypyrimidines/O may/O play/O a/O role/O in/O B/O cell/O selection/O before/O immunization/O with/O Z/O -/O DNA/O ./O
Technetium/O -/O 99m/O methylene/O diphosphonate/O scintimammography/O for/O evaluation/O of/O palpable/O breast/O masses/O ./O
INTERVENTIONS/O :/O Study/O patients/O were/O randomly/O divided/O into/O four/O parallel/O groups/O to/O receive/O either/O terbinafine/O 250/O mg/O a/O day/O for/O 12/O or/O 16/O weeks/O (/O groups/O T12/O and/O T16/O )/O or/O itraconazole/O 400/O mg/O a/O day/O for/O 1/O week/O in/O every/O 4/O weeks/O for/O 12/O or/O 16/O weeks/O (/O groups/O I3/O and/O I4/O )./O
Nuclear/O receptors/O (/O NRs/O )/O can/O function/O as/O ligandinducible/O transregulators/O in/O both/O mammalian/O and/O yeast/O cells/O ,/O indicating/O that/O important/O features/O of/O transcriptional/O control/O have/O been/O conserved/O throughout/O evolution/O ./O
When/O tethered/O to/O a/O heterologous/O DNA/O -/O binding/O domain/O ,/O PSU1/I can/O activate/O transcription/O on/O its/O own/O ./O
OBJECTIVE/O :/O To/O follow/O -/O up/O prospectively/O patients/O with/O arthritis/O after/O infection/O with/O beta/O -/O haemolytic/O streptococci/O of/O Lancefield/O group/O A/O (/O beta/O HSA/O ),/O with/O emphasis/O on/O clinical/O characteristics/O and/O serological/O features/O ./O
Bacteria/O can/O also/O cause/O a/O labyrinthitis/O acting/O directly/O on/O the/O inner/O ear/O :/O among/O these/O ,/O Treponemas/O Pallidum/O ,/O a/O spirochaete/O which/O causes/O syphilis/O and/O Borrelia/O Burgdorferi/O ,/O a/O spirochaete/O that/O causes/O Lyme/O Disease/O ,/O must/O be/O mentioned/O ./O
We/O found/O that/O the/O expression/O of/O the/O protein/O was/O maximum/O in/O mitosis/O and/O minimum/O in/O G1/O ,/O which/O correlated/O with/O the/O expression/O of/O its/O messenger/O RNA/O ./O
These/O findings/O demonstrate/O that/O signature/O -/O tagged/O mutagenesis/O is/O a/O viable/O approach/O to/O identify/O bacterial/O genes/O associated/O with/O the/O ability/O to/O infect/O the/O urinary/O tract/O ./O
Pathol/O ./O
The/O eukaryotic/O cell/O cycle/O is/O governed/O in/O part/O by/O the/O periodic/O transcription/O of/O cyclin/I genes/I ,/O whose/O protein/O products/O associate/O with/O and/O positively/O regulate/O the/O cyclin/I -/I dependent/I kinases/I ./O
The/O GAC1/I gene/I encodes/O the/O regulatory/O subunit/O for/O a/O type/I 1/I serine/I //I threonine/I phosphoprotein/I phosphatase/I ,/O Glc7/I ./O
The/O results/O demonstrate/O that/O the/O Glc7/I phosphatase/I and/O its/O Gac1/I regulatory/O subunit/O play/O positive/O roles/O in/O HSF/I activation/O of/O CUP1/I transcription/O ./O
MEF/I and/O AML1B/I synergistically/O transactivated/O an/O interleukin/I 3/I promoter/I reporter/I gene/I construct/I ,/O yet/O the/O activating/O activity/O of/O MEF/I was/O abolished/O when/O MEF/I was/O coexpressed/O with/O AML1/I //O ETO/I ./O
Mechanistically/O ,/O the/O presence/O of/O the/O GRR/O appears/O to/O stop/O further/O degradation/O of/O p50/I and/O to/O stabilize/O the/O molecule/O ./O
This/O phosphorylation/O can/O be/O catalyzed/O by/O a/O break/O -/O ended/O double/O -/O stranded/O DNA/O -/O activated/O protein/O kinase/O activity/O from/O the/O sea/O urchin/O nucleus/O in/O vitro/O ./O
Concomitantly/O ,/O the/O total/O cellular/O level/O of/O p21/I increased/O severalfold/O via/O a/O posttranscriptional/O mechanism/O ./O
Moreover/O ,/O when/O added/O to/O the/O osteoclast/O cultures/O ,/O mrIhh/I -/I N/I markedly/O stimulated/O the/O formation/O of/O resorption/O pits/O on/O dentine/O slices/O ./O
Overall/O ,/O our/O results/O suggest/O that/O resistant/O genotypes/O exist/O among/O the/O WAD/O goat/O population/O ./O
The/O molecular/O mechanism/O by/O which/O Gle2p/I and/O the/O Gle2p/I -/O Nup116p/I interaction/O function/O in/O mRNA/O export/O is/O unknown/O ./O
The/O Fyn/I NH2/I terminus/I was/O necessary/O but/O not/O sufficient/O for/O interaction/O with/O zeta/O and/O both/O Fyn/I kinase/I and/O SH2/I domains/I were/O required/O ,/O directing/O phosphorylation/O of/O zeta/I ITAM/I tyrosines/O and/O binding/O to/O zeta/I ITAM/I phosphotyrosines/O ./O
In/O budding/O yeast/O ,/O the/O protein/O Skp1p/I ,/O the/O cullin/I -/I family/I member/I Cdc53p/I ,/O and/O the/O F/O -/O box/O //O WD/O -/O repeat/O protein/O Cdc4p/I form/O the/O SCFCdc4p/I ubiquitin/I ligase/I complex/O ,/O which/O targets/O the/O cyclin/I -/I dependent/I kinase/I (/O Cdk/I )/O inhibitor/O Sic1p/I for/O proteolysis/O [/O 3/O ]/O [/O 4/O ]/O [/O 5/O ]/O [/O 6/O ]/O [/O 7/O ]/O [/O 8/O ]./O
We/O show/O here/O that/O ,/O despite/O their/O structural/O and/O functional/O similarities/O ,/O the/O pop1/I and/O pop2/I genes/I fail/O to/O complement/O each/O other/O '/O s/O deletion/O phenotypes/O ,/O indicating/O that/O they/O perform/O non/O -/O redundant/O ,/O but/O potentially/O interdependent/O ,/O functions/O in/O proteolysis/O ./O
Antithrombin/I III/I prevents/O 60/O min/O warm/O intestinal/O ischemia/O reperfusion/O injury/O in/O rats/O ./O
In/O retrospect/O ,/O the/O diagnoses/O were/O reconsidered/O applying/O strict/O criteria/O ./O
These/O observations/O of/O elevated/O serum/I lipase/I and/O serum/O CA/I 19/I -/I 9/I in/O Sjogren/O '/O s/O syndrome/O without/O evidence/O of/O malignancy/O may/O reflect/O pancreatic/O involvement/O in/O this/O disorder/O ./O
Acute/O pancreatitis/O as/O a/O complication/O of/O polyarteritis/O nodosa/O ./O
Significantly/O greater/O improvement/O (/O p/O /O 60/O -/O fold/O )/O in/O LNCaP/O -/O r/O cells/O ,/O consistent/O with/O previously/O reported/O overexpression/O of/O FN/I in/O prostate/O cancer/O ./O
We/O also/O observed/O that/O cell/O surface/O CD4/I (-)/O CD8/I (-)/O CD3/I (-)/O cells/O with/O rearranged/I TCR/I genes/I developed/O from/O Id3/I -/O transduced/O but/O not/O from/O control/O -/O transduced/O pre/O -/O T/O cells/O in/O an/O FTOC/O ./O
As/O determined/O in/O a/O modified/O yeast/O two/O -/O hybrid/O system/O ,/O mIRS3/I bound/O strongly/O to/O the/O p85/I subunit/I of/O phosphatidylinositol/I 3/I -/I kinase/I ./O
Insulin/I stimulation/O promoted/O the/O association/O of/O mIRS3/I with/O p85/I ,/O SHP2/I ,/O Nck/I ,/O and/O Shc/I ./O
The/O mRNA/O expression/O of/O RFX1/I ,/O RFX2/I ,/O and/O RFX3/I was/O detected/O ubiquitously/O ,/O but/O in/O transient/O -/O transfection/O assays/O ,/O multimerized/I RFX/I binding/I sites/I in/O front/O of/O a/O basal/O promoter/O efficiently/O functioned/O in/O a/O tissue/O -/O and/O lineage/O -/O specific/O manner/O ./O
In/O the/O case/O of/O the/O unspliceable/O intron/O ,/O repression/O of/O luciferase/I expression/O likely/O involved/O two/O AUF1/I -/I binding/I sequences/I ,/O since/O luciferase/I expression/O was/O increased/O by/O deletion/O of/O these/O sites/O ./O
Thus/O ,/O VDR/I acts/O selectively/O on/O the/O two/O components/O required/O for/O activation/O of/O this/O promoter/O //O enhancer/O :/O it/O competes/O with/O NFAT1/I for/O binding/O to/O the/O composite/O site/O ,/O positioning/O itself/O adjacent/O to/O Jun/I -/O Fos/I on/O the/O DNA/O ./O
Two/O evolutionarily/O conserved/O kinases/O ,/O the/O cyclin/I B/I (/O Clb/I )//O cyclin/I -/I dependent/I kinase/I (/O Cdk/I //O Cdc28p/I )/O and/O Cdc7p/I along/O with/O its/O interacting/O factor/O Dbf4p/I ,/O are/O required/O late/O in/O G1/O to/O initiate/O DNA/O replication/O ./O
The/O RanQ69L/I preincubation/O leads/O to/O accumulation/O of/O CRM1/I at/O the/O cytoplasmic/O periphery/O of/O the/O nuclear/O pore/O complex/O (/O NPC/O )/O in/O association/O with/O the/O p62/I complex/I and/O Can/I //O Nup214/I ./O
All/O of/O the/O elements/O exhibited/O a/O uniform/O structure/O ./O
In/O contrast/O ,/O the/O deduced/O amino/O acid/O sequence/O of/O a/O second/O family/O (/O ART5/I )/O of/O transferases/O ,/O cloned/O from/O murine/O lymphoma/O cells/O and/O expressed/O in/O high/O abundance/O in/O testis/O ,/O displays/O a/O hydrophobic/O amino/O terminus/O ,/O consistent/O with/O a/O signal/O sequence/O ,/O but/O lacks/O a/O hydrophobic/O signal/O sequence/O at/O its/O carboxyl/O terminus/O ,/O suggesting/O that/O the/O protein/O is/O destined/O for/O export/O ./O
RESULTS/O :/O Each/O year/O ,/O on/O average/O 39/O %/O of/O cases/O seen/O in/O Sardinia/O are/O notified/O ;/O 646/O (/O 40/O %)/O of/O the/O 1591/O patients/O notified/O during/O the/O study/O period/O were/O never/O seen/O by/O regional/O medical/O centres/O ./O
This/O dimer/O interface/O is/O likely/O important/O for/O increasing/O the/O DNA/O -/O binding/O specificity/O and/O affinity/O of/O the/O trimeric/O form/O of/O HSF/I ,/O as/O well/O as/O for/O increasing/O cooperativity/O between/O adjacent/O trimers/O ./O
The/O paramyxovirus/I fusion/I (/I F/I )/I protein/I mediates/O membrane/O fusion/O ./O
Additionally/O ,/O deletion/O analysis/O of/O the/O UCP2/I promoter/O -/O PLAP/I constructs/O indicated/O that/O the/O minimal/O region/O exhibiting/O the/O promoter/O activity/O was/O located/O between/O nt/O -/O 33/O and/O +/O 100/O ,/O and/O that/O a/O strong/O enhancer/O was/O present/O within/O 601/O bp/O of/O the/O 5/O '-/O promoter/O region/O ./O
The/O hTERT/I gene/I encompasses/O more/O than/O 37kb/O and/O consists/O of/O 16/O exons/O ./O
Both/O betaAPP/I mRNA/I and/O Abeta/I levels/O are/O increased/O in/O trisomy/O 21/O ./O
In/O reperfusion/O B/O ,/O only/O the/O diabetic/O group/O demonstrated/O a/O significant/O increase/O in/O IL/I -/I 8/I concentrations/O at/O 1/O and/O 15/O min/O compared/O to/O nondiabetics/O ./O
This/O repression/O was/O reversed/O agonists/O of/O either/O receptor/O demonstrating/O a/O functional/O interaction/O between/O NCoR/I and/O PPARalpha/I ./O RXRalpha/I heterodimeric/O complexes/O in/O mammalian/O cells/O ./O
In/O the/O present/O study/O ,/O we/O show/O that/O SRm160/I //I 300/I is/O required/O for/O a/O purine/O -/O rich/O ESE/I to/O promote/O the/O splicing/O of/O a/O pre/O -/O mRNA/O derived/O from/O the/O Drosophila/I doublesex/I gene/I ./O
Spc42p/I also/O was/O identified/O as/O a/O component/O of/O a/O cytoplasmic/O SPB/O subcomplex/O containing/O Spc94p/I //O Nud1p/I ,/O Cnm67p/I ,/O and/O Spc42p/I ./O
The/O average/O coefficients/O of/O correlation/O were/O 0/O ./O 9998/O and/O 0/O ./O 9993/O for/O the/O QMF/O and/O the/O QIT/O system/O ,/O respectively/O ./O
The/O 5/O -/O year/O OS/O for/O stage/O IIIB/O was/O 30/O ./O 9/O %,/O compared/O to/O 7/O ./O 8/O %/O for/O stage/O IV/O ./O
Furthermore/O ,/O heparin/I lyase/I treatment/O of/O extracts/O of/O cells/O expressing/O recombinant/I YD/I -/I repeat/I protein/I releases/O this/O protein/O from/O high/O molecular/O mass/O aggregates/O ./O
The/O coefficient/O of/O determination/O ,/O r2/O ,/O of/O the/O other/O scores/O ranged/O from/O 0/O ./O 56/O to/O 0/O ./O 61/O ./O
While/O determination/O of/O the/O protein/O content/O of/O the/O formulae/O gave/O no/O valid/O information/O ,/O RAST/O //O EAST/O inhibition/O was/O highest/O for/O cow/O '/O s/O milk/O ,/O followed/O by/O the/O partially/O hydrolysed/O whey/O formula/O ,/O partially/O hydrolysed/O whey/O //O casein/I formula/O ,/O soy/I //I pork/I collagen/I formula/O ,/O and/O the/O amino/O acid/O formula/O ./O
In/O light/O of/O the/O importance/O of/O GnRHR/I ,/O the/O molecular/O mechanisms/O underlying/O the/O transcriptional/O regulation/O of/O the/O human/I GnRHR/I (/O hGnRHR/I )/O gene/O become/O a/O key/O issue/O in/O understanding/O human/O reproduction/O ./O
Competitive/O mobility/O shift/O assays/O using/O either/O alphaT3/O -/O 1/O nuclear/O extract/O or/O recombinant/I SF/I -/I 1/I protein/I clearly/O indicated/O that/O SF/I -/I 1/I is/O able/O to/O interact/O specifically/O with/O this/O GSE/I element/I positioned/O at/O -/O 134/O ./O
Grade/O 3/O mucositis/O was/O reported/O in/O 1/O patient/O ./O
CDK4/I kinase/I activities/O were/O unaffected/O ,/O as/O were/O the/O levels/O of/O the/O CDK/I inhibitor/O p21Cip1/I present/O in/O cyclin/I E/I immunocomplexes/I ./O
The/O recombinant/O purified/O protein/O expressed/O in/O the/O baculovirus/O system/O had/O an/O approximate/O molecular/O size/O 20/O kDa/O with/O amino/O -/O terminal/O sequence/O of/O AVQGP/O ./O
Induction/O of/O the/O urokinase/I promoter/I by/O HGF/I //O SF/I via/O the/O Met/I receptor/I was/O blocked/O by/O co/O -/O expression/O of/O a/O dominant/O -/O negative/O Grb2/I and/O Sos1/I expression/O construct/O ./O
Serine/O phosphorylation/O of/O STAT3/I was/O only/O apparent/O after/O somatostatin/I treatment/O and/O was/O abolished/O by/O pertussis/I toxin/I or/O PD/O 98059/O ,/O together/O with/O the/O associated/O increases/O in/O proliferation/O ./O
Nevertheless/O ,/O we/O demonstrate/O that/O the/O entire/O three/O -/O component/O yeast/O capping/O apparatus/O ,/O consisting/O of/O RNA/I 5/I '-/I triphosphatase/I (/O Cet1p/I ),/O RNA/I guanylyltransferase/I (/O Ceg1p/I ),/O and/O Abd1p/I could/O be/O replaced/O in/O vivo/O by/O the/O two/O -/O component/O mammalian/O apparatus/O consisting/O of/O a/O bifunctional/O triphosphatase/I -/I guanylyltransferase/I Mce1p/I and/O the/O methyltransferase/I Hcm1/I (/I 121/I -/I 476/I )/I p/I ./O
The/O IC50/O values/O for/O rat/O and/O dog/O urinary/O bladder/O were/O 3/O ./O 9/O x/O 10/O (-/O 6/O )/O M/O and/O 3/O ./O 8/O x/O 10/O (-/O 6/O )/O M/O ,/O respectively/O ./O
Although/O it/O has/O two/O potential/O binding/O sites/O ,/O the/O purified/O MerR/I homodimer/I binds/O only/O one/O Hg/O (/O II/O )/O ion/O ,/O employing/O Cys82/O from/O one/O monomer/O and/O Cys117/O and/O Cys126/O from/O the/O other/O ./O
The/O influence/O of/O Epstein/O -/O Barr/O virus/O seropositivity/O on/O the/O efficacy/O of/O intravenous/O immune/I globulin/I in/O children/O with/O immune/O thrombocytopenic/O purpura/O ./O
The/O results/O of/O the/O lab/O and/O field/O tests/O yielded/O high/O levels/O of/O infestation/O in/O larvae/O with/O values/O ranging/O from/O 90/O to/O 100/O %/O and/O from/O 85/O to/O 95/O %,/O respectively/O ./O
Amisulpride/O 400/O mg/O had/O several/O adverse/O effects/O on/O psychomotor/O and/O ,/O although/O less/O severe/O ,/O on/O cognitive/O performance/O on/O the/O fifth/O day/O only/O ./O
MutY/I is/O an/O adenine/I -/I DNA/I glycosylase/I with/O specificity/O for/O mismatches/O involving/O 8/O -/O oxoguanine/O (/O oG/O ./O A/O )/O or/O guanine/O (/O G/O ./O A/O )./O
The/O kinetics/O of/O kinase/O activity/O within/O these/O complexes/O compared/O to/O CheA/I alone/O indicate/O approximately/O a/O 50/O %/O decrease/O in/O the/O KM/O for/O ATP/O and/O a/O 100/O -/O fold/O increase/O in/O the/O Vmax/O ./O
Latexin/I ,/O a/O carboxypeptidase/I A/I inhibitor/O ,/O is/O expressed/O in/O a/O cell/O type/O -/O specific/O manner/O in/O both/O central/O and/O peripheral/O nervous/O systems/O in/O the/O rat/O ./O
Regression/O analyses/O identified/O 7/O risk/O and/O 7/O protective/O factors/O with/O minimal/O overlap/O ./O
During/O 1985/O ,/O 1990/O ,/O and/O 1995/O ,/O respectively/O ,/O 11/O ./O 7/O ,/O 11/O ./O 3/O ,/O and/O 11/O ./O 4/O infants/O per/O 100/O ,/O 000/O live/O births/O had/O a/O diagnosis/O of/O HSV/O (/O P/O =./O 98/O )./O
Subsets/O of/O patients/O were/O performed/O according/O to/O the/O severity/O of/O trauma/O (/O ISS/O /O 32/O ),/O based/O on/O the/O different/O injury/O pattern/O ,/O and/O survivors/O versus/O nonsurvivors/O as/O well/O ./O
The/O median/O age/O was/O 33/O years/O (/O range/O 17/O -/O 56/O years/O )./O
Developmental/O follow/O -/O up/O at/O age/O 2/O years/O was/O performed/O ./O
In/O the/O whole/O group/O of/O infected/O children/O ,/O an/O age/O -/O specific/O z/O score/O /=/O 195/O -/O fold/O higher/O (/O amoxicillin/O )./O
Null/O alleles/O of/O SAS4/I and/O SAS5/I bypassed/O the/O role/O of/O the/O Abf1p/I binding/I site/I of/O the/O HMR/I -/I E/I silencer/I but/O not/O the/O role/O of/O the/O ACS/I or/O Rap1p/I binding/I site/I ./O
Recent/O molecular/O analysis/O has/O revealed/O that/O the/O S/I locus/I is/O highly/O polymorphic/O and/O contains/O several/O genes/O ,/O i/O ./O e/O .,/O SLG/I ,/O SRK/I ,/O the/O as/O -/O yet/O -/O unidentified/O pollen/O S/O gene/O (/O s/O ),/O and/O other/O linked/O genes/O ./O
A/O cDNA/O encoding/O a/O putative/O RNA/I and/I //I or/I DNA/I helicase/I has/O been/O isolated/O from/O Arabidopsis/O thaliana/O cDNA/O libraries/O ./O
In/O vivo/O ,/O MyoD/I requires/O this/O tryptophan/O motif/O to/O evoke/O chromatin/O remodeling/O in/O the/O Myogenin/I promoter/I and/O to/O activate/O Myogenin/I transcription/O ./O
RESULTS/O :/O 256/O Periods/O of/O TTP/O or/O PUNP/O were/O reported/O by/O men/O and/O 174/O by/O women/O ./O
Feed/O intake/O and/O BW/O gains/O were/O decreased/O (/O P/O /O 5x/O normal/O in/O 2/O ./O 4/O %/O of/O patients/O ./O
Thus/O ,/O NART/O -/O R/O performance/O may/O not/O be/O a/O valid/O estimate/O of/O baseline/O IQ/O for/O patients/O with/O neurologic/O disorders/O with/O suspected/O language/O impairment/O ./O
Activated/O areas/O have/O been/O identified/O by/O means/O of/O cross/O -/O correlation/O analysis/O ./O
Natural/O Haemophilus/O influenzae/O type/O b/O capsular/O polysaccharide/O antibodies/O in/O 412/O infants/O and/O children/O from/O West/O Africa/O (/O Burkina/O -/O Faso/O )/O and/O France/O :/O a/O cross/O -/O sectional/O serosurvey/O ./O
In/O this/O study/O ,/O we/O identified/O Sp1/I and/O Sp3/I as/O major/O factors/O binding/O to/O the/O Sp1/I sites/I of/O the/O p21/I //O WAF1/I //O Cip1/I promoter/O in/O MG63/O cells/O through/O electrophoretic/O mobility/O shift/O assays/O and/O showed/O that/O TSA/O treatment/O did/O not/O change/O their/O binding/O activities/O ./O
Galoyan/O has/O summarized/O the/O results/O of/O his/O discovery/O of/O cardioactive/O neurohormones/O ./O
To/O study/O the/O regulation/O of/O its/O expression/O ,/O the/O human/I aldehyde/I reductase/I gene/I and/O promoter/O were/O cloned/O and/O characterized/O ./O
Immunohistochemical/O staining/O with/O MIB/I -/I 1/I and/O p53/I antibodies/I showed/O low/O (/=/O 87/O %)/O were/O receiving/O irbesartan/O //O HCTZ/O alone/O ./O
Modification/O of/O dopamine/I D2/I receptor/I activity/O by/O pergolide/O in/O Parkinson/O '/O s/O disease/O :/O an/O in/O vivo/O study/O by/O PET/O ./O
High/O -/O affinity/O binding/O sites/O for/O both/O GR/I and/O AP/I -/I 1/I nucleoproteins/I were/O identified/O at/O adjacent/O elements/O within/O the/O nGRE/O ./O
When/O the/O 73/O -/O bp/O fragment/O was/O fused/O to/O an/O alpha1/I -/I globin/I promoter/O -/O CAT/I construct/O and/O cotransfected/O with/O CCAAT/I transcription/I factor/I 1/I (/O CTF1/I )//O NF1/I into/O Drosophila/O Schneider/O SL2/O insect/O cells/O (/O which/O lack/O NF1/I -/I like/I proteins/I )/O trans/O -/O activation/O of/O CAT/I activity/O was/O observed/O ./O
Western/O blot/O analysis/O showed/O a/O rapid/O corresponding/O increase/O in/O p21WAF1/I //O CIP1/I protein/O ,/O whereas/O protein/O levels/O of/O another/O member/O of/O the/O cyclin/I -/I dependent/I kinase/I inhibitor/I family/I ,/O p27kip1/I ,/O were/O unchanged/O ./O
Aggregation/O of/O vHnf1/I -/O deficient/O embryonic/O stem/O cells/O with/O wild/O -/O type/O tetraploid/O embryos/O ,/O which/O contribute/O exclusively/O to/O extraembryonic/O tissues/O ,/O rescues/O periimplantation/O lethality/O and/O allows/O development/O to/O progress/O to/O early/O organogenesis/O ./O
nos/I -/I 1/I and/O nos/I -/I 2/I ,/O two/O genes/O related/O to/O Drosophila/I nanos/I ,/O regulate/O primordial/O germ/O cell/O development/O and/O survival/O in/O Caenorhabditis/O elegans/O ./O
Although/O upstream/O regulators/O of/O Tec/I family/I kinases/I are/O relatively/O well/O characterized/O ,/O little/O is/O known/O of/O the/O downstream/O effectors/O of/O these/O enzymes/O ./O
Efficient/O phosphorylation/O of/O BRDG1/I by/O Tec/I required/O the/O PH/I and/O SH2/I domains/I as/O well/O as/O the/O kinase/O domain/O of/O the/O latter/O ./O
CONCLUSION/O :/O These/O findings/O imply/O that/O eotaxin/O either/O is/O mechanistically/O involved/O in/O acute/O asthma/O or/O serves/O as/O a/O biomarker/O for/O activity/O of/O the/O CCR3/I receptor/I ligand/I system/O ,/O which/O is/O functionally/O linked/O to/O asthma/O ./O
The/O expression/O analysis/O of/O the/O KlHIS4/I gene/I under/O phosphate/O starvation/O or/O high/O adenine/O supply/O shows/O that/O factors/O ,/O such/O as/O Bas1/I or/O Bas2/I ,/O involved/O in/O the/O basal/O control/O may/O also/O operate/O in/O a/O different/O way/O in/O K/O ./O lactis/O ./O
These/O thyroid/O hormone/O changes/O may/O be/O mediated/O in/O part/O by/O cytokines/O or/O other/O inflammatory/O mediators/O ,/O acting/O at/O the/O level/O of/O the/O hypothalamus/O and/O pituitary/O gland/O ,/O the/O thyroid/O gland/O ,/O and/O the/O hepatic/I deiodinase/I system/O ./O
ESS/O type/O 1/O ,/O with/O FT3/O low/O and/O FT4/O and/O TSH/I normal/O ,/O is/O the/O most/O frequent/O form/O ./O
METHODS/O :/O We/O studied/O 20/O symptomatic/O patients/O with/O HOCM/O (/O 12/O men/O ),/O mean/O age/O 52/O +/-/O 17/O years/O ,/O before/O and/O after/O septal/O reduction/O using/O echocardiography/O and/O electrocardiogram/O (/O ECG/O )./O
Paleoceanographic/O data/O from/O the/O Laurentian/O Fan/O ,/O used/O as/O a/O proxy/O for/O sea/O surface/O temperature/O ,/O reveal/O that/O surface/O slope/O waters/O north/O of/O the/O Gulf/O Stream/O experienced/O warming/O during/O the/O Little/O Ice/O Age/O of/O the/O 16th/O to/O 19th/O centuries/O and/O support/O the/O notion/O of/O an/O NAO/O -/O driven/O coupled/O system/O ./O
This/O effect/O required/O (/O i/O )/O IR/I activation/O since/O it/O was/O abrogated/O by/O IR/I mutation/O at/O tyrosines/O 1162/O and/O 1163/O and/O (/O ii/O )/O NF/I -/I kappaB/I activation/O since/O it/O was/O abolished/O by/O overexpression/O of/O dominant/I -/I negative/I IkappaB/I -/I alpha/I (/I A32/I //I 36/I )/I and/O mimicked/O by/O overexpression/O of/O the/O NF/I -/I kappaB/I c/I -/I Rel/I subunit/I ./O
The/O factor/O designated/O B/O formed/O a/O complex/O centered/O on/O the/O sequence/O TGTGGT/O ,/O a/O core/O motif/O recognized/O by/O members/O of/O the/O AML/I //I CBFalpha/I transcription/I factor/I family/I ./O
Furthermore/O ,/O overexpression/O of/O AML3/I //O CBFalpha1/I could/O rescue/O the/O AML1/I -/O ETO/I repression/O ./O
We/O examined/O Akt/I activation/O in/O Lyn/I -,/O Syk/I -/O and/O Btk/I -/O deficient/O DT40/O cells/O and/O B/O cells/O from/O Lyn/I (-/-)/I mice/O ./O
Regulators/O of/O G/I protein/I signaling/I (/I RGS/I )/I proteins/I that/O contain/O DEP/I (/O disheveled/I ,/O EGL/I -/I 10/I ,/O pleckstrin/I )/O and/O GGL/I (/O G/I protein/I gamma/I subunit/I -/I like/I )/O domains/O form/O a/O subfamily/O that/O includes/O the/O mammalian/I RGS/I proteins/I RGS6/I ,/O RGS7/I ,/O RGS9/I ,/O and/O RGS11/I ./O
Cloning/O and/O expression/O of/O a/O specific/O human/I alpha/I 1/I ,/I 2/I -/I mannosidase/I that/O trims/O Man9GlcNAc2/O to/O Man8GlcNAc2/O isomer/O B/O during/O N/O -/O glycan/O biosynthesis/O ./O
The/O ORs/O of/O GC/O ,/O adjusted/O for/O age/O and/O sex/O ,/O varied/O from/O 17/O ./O 1/O ,/O for/O those/O with/O baseline/O diagnoses/O of/O superficial/O intestinal/O metaplasia/O (/O IM/O ),/O to/O 29/O ./O 3/O ,/O for/O those/O with/O deep/O IM/O or/O mild/O dysplasia/O (/O DYS/O )/O or/O IM/O with/O glandular/O atrophy/O and/O neck/O hyperplasia/O ,/O to/O 104/O ./O 2/O ,/O for/O those/O with/O moderate/O or/O severe/O DYS/O ,/O as/O compared/O with/O subjects/O with/O superficial/O gastritis/O (/O SG/O )/O or/O chronic/O atrophic/O gastritis/O (/O CAG/O )/O at/O baseline/O ./O
Here/O we/O report/O that/O Dbp5p/I and/O Rat7p/I interact/O through/O their/O Nterminal/O domains/O ./O
Thus/O ,/O the/O nematode/O genes/O could/O be/O the/O homologs/I of/I Hh/I molecules/I in/O other/O phyla/O ./O
A/O subset/O of/O mutations/O in/O the/O Psi/I synthase/I domain/I impairs/O association/O of/O the/O altered/O Cbf5p/I proteins/I with/O selected/O box/O H/I //I ACA/I snoRNAs/I ,/O suggesting/O that/O the/O functional/O catalytic/O domain/O is/O essential/O for/O that/O interaction/O ./O
Although/O the/O Src/I tyrosine/I kinase/I induces/O constitutive/O Stat3/I phosphorylation/O on/O tyrosine/O ,/O activation/O of/O Stat3/I -/O mediated/O gene/O regulation/O requires/O both/O tyrosine/O and/O serine/O phosphorylation/O of/O Stat3/I ./O
The/O transcription/I factor/I CHOP/I (/O C/I //I EBP/I homologous/I protein/I 10/I )/O is/O a/O bZIP/I protein/I induced/O by/O a/O variety/O of/O stimuli/O that/O evoke/O cellular/O stress/O responses/O and/O has/O been/O shown/O to/O arrest/O cell/O growth/O and/O to/O promote/O programmed/O cell/O death/O ./O
Thus/O ,/O CHOP/I not/O only/O is/O a/O negative/O or/O a/O positive/O regulator/O of/O C/I //I EBP/I target/O genes/O but/O also/O ,/O when/O tethered/O to/O AP/I -/I 1/I factors/I ,/O can/O activate/O AP/I -/I 1/I target/O genes/O ./O
This/O motif/O ,/O first/O described/O for/O the/O Drosophila/I homeobox/I activator/I DEAF/I -/I 1/I ,/O identifies/O an/O emerging/O group/O of/O metazoan/O transcriptional/O modulators/O ./O
RNase/I MRP/I is/O a/O ribonucleoprotein/O endoribonuclease/O that/O has/O been/O shown/O to/O have/O roles/O in/O both/O mitochondrial/O DNA/O replication/O and/O nuclear/I 5/I ./I 8S/I rRNA/I processing/O ./O
We/O have/O examined/O the/O regulation/O of/O the/O FGFR/I -/I 1/I gene/I (/O cek/I -/I 1/I )/O in/O avian/O myogenic/O cultures/O by/O immunocytochemistry/O and/O Northern/O blot/O analysis/O ./O
Regulation/O of/O avian/I fibroblast/I growth/I factor/I receptor/I 1/I (/O FGFR/I -/I 1/I )/O gene/O expression/O during/O skeletal/O muscle/O differentiation/O ./O
The/O backbone/O dynamics/O of/O residues/O located/O in/O the/O folded/O part/O of/O CRP2/I (/O LIM2/I )/O R122A/I have/O been/O characterized/O by/O proton/O -/O detected/O (/O 15/O )/O N/O NMR/O spectroscopy/O ./O
Rac/I causes/O uncapping/O of/O actin/I filaments/I (/O F/I -/I actin/I )/O at/O the/O plus/O -/O ends/O ,/O through/O phosphatidylinositol/O 4/O ,/O 5/O bisphosphate/O (/O PIP2/O ),/O and/O eventually/O induces/O membrane/O ruffling/O ./O
However/O ,/O a/O specific/O ICE/I //O caspase/I -/I 1/I inhibitor/O called/O N1445/O completely/O abolished/O the/O CK/I -/O induced/O apoptosis/O by/O reactivating/O PKB/I ,/O but/O without/O affecting/O the/O CK/I -/O induced/O suppression/O of/O Ras/I transformation/O ./O
OBJECTIVE/O :/O Although/O the/O preponderance/O of/O findings/O offer/O support/O for/O transient/O (/O where/O is/O it/O ?)/O as/O opposed/O to/O sustained/O (/O what/O is/O it/O ?)/O deficit/O ,/O a/O need/O remains/O for/O specific/O depiction/O of/O the/O deficit/O ./O
The/O AL/O -/O R8/O SI/O :/O the/O next/O generation/O staging/O container/O for/O plutonium/O pits/O at/O the/O USDOE/O Pantex/O Plant/O ./O
RESULTS/O :/O Factors/O associated/O with/O significantly/O (/O P/O <./O 05/O )/O increased/O risk/O of/O treatment/O failure/O in/O a/O Cox/O multivariate/O analysis/O included/O age/O older/O than/O 45/O years/O (/O relative/O hazard/O ,/O 1/O ./O 17/O ;/O 95/O %/O confidence/O interval/O [/O CI/O ],/O 1/O ./O 02/O -/O 1/O ./O 33/O ),/O Karnofsky/O performance/O score/O less/O than/O 90/O %/O (/O 1/O ./O 27/O ;/O 95/O %/O CI/O ,/O 1/O ./O 07/O -/O 1/O ./O 51/O ),/O absence/O of/O hormone/O receptors/O (/O 1/O ./O 31/O ;/O 95/O %/O CI/O ,/O 1/O ./O 15/O -/O 1/O ./O 51/O ),/O prior/O use/O of/O adjuvant/O chemotherapy/O (/O 1/O ./O 31/O ;/O 95/O %/O CI/O ,/O 1/O ./O 10/O -/O 1/O ./O 56/O ),/O initial/O disease/O -/O free/O survival/O interval/O after/O adjuvant/O treatment/O of/O no/O more/O than/O 18/O months/O (/O 1/O ./O 99/O ;/O 95/O %/O CI/O ,/O 1/O ./O 62/O -/O 2/O ./O 43/O ),/O metastases/O in/O the/O liver/O (/O 1/O ./O 47/O ;/O 95/O %/O CI/O ,/O 1/O ./O 20/O -/O 1/O ./O 80/O )/O or/O central/O nervous/O system/O (/O 1/O ./O 56/O ;/O 95/O %/O CI/O ,/O 0/O ./O 99/O -/O 2/O ./O 46/O [/O approaches/O significance/O ])/O vs/O soft/O tissue/O ,/O bone/O ,/O or/O lung/O ,/O 3/O or/O more/O sites/O of/O metastatic/O disease/O (/O 1/O ./O 32/O ;/O 95/O %/O CI/O ,/O 1/O ./O 13/O -/O 1/O ./O 54/O ),/O and/O incomplete/O response/O vs/O complete/O response/O to/O standard/O -/O dose/O chemotherapy/O (/O 1/O ./O 65/O ;/O 95/O %/O CI/O ,/O 1/O ./O 36/O -/O 1/O ./O 99/O )./O
One/O form/O of/O the/O SBEI/I gene/I transcript/I in/O 12/O -/O day/O old/O kernels/O contained/O the/O exon/O I/O +/O II/O +/O III/O combination/O at/O the/O 5/O '/O end/O ,/O whereas/O other/O forms/O differed/O by/O inclusion/O of/O intron/O 1/O or/O exclusion/O of/O exon/O II/O sequences/O ./O
In/O PC/O ,/O rare/O MNGCs/O had/O intranuclear/O inclusions/O and/O grooves/O ./O
16/O percent/O ,/O P/O /O 2/O SD/O above/O normal/O (/O P/O /O 0/O ./O 05/O )/O and/O a/O significant/O decrease/O in/O Qs/O //O Q/O tau/O ratio/O (/O P/O /O 70/O %/O mortality/O in/O 3/O months/O ,/O despite/O mechanical/O ventilation/O ./O
We/O found/O that/O TCR/I signaling/O induces/O AP/I -/I 1/I binding/O to/O this/O site/O and/O regulates/O the/O fasl/I promoter/I function/O in/O a/O fashion/O dependent/O on/O NF/I -/I kappaB/I binding/O ./O
Thus/O ,/O patients/O with/O metastatic/O melanoma/O are/O not/O tolerant/O to/O gp100/I Ag/I based/O on/O the/O detection/O of/O CD8/I +/I T/O cells/O specific/O for/O multiple/O HLA/I -/I A/I */I 0201/I -/O restricted/O ,/O gp100/I -/O derived/O epitopes/O ./O
Approximately/O 20/O %/O of/O ALCLs/O that/O express/O ALK/I do/O not/O contain/O the/O t/O (/O 2/O ;/O 5/O ),/O suggesting/O that/O other/O genetic/O abnormalities/O can/O result/O in/O aberrant/O ALK/I expression/O ./O
In/O addition/O ,/O expected/O decreases/O in/O ATIC/I enzymatic/O function/O in/O ATIC/I -/O ALK/I -/O containing/O lymphomas/O may/O render/O these/O tumors/O more/O sensitive/O to/O antifolate/O drugs/O such/O as/O methotrexate/O ./O
Following/O the/O observation/O that/O non/O -/O organ/O -/O specific/O antibodies/O are/O related/O with/O pregnancy/O loss/O and/O preeclampsia/O ,/O the/O role/O of/O organ/O -/O specific/O antibodies/O is/O currently/O being/O extensively/O investigated/O ./O
Manganese/O ions/O were/O found/O to/O be/O essential/O for/O autophosphorylation/O of/O BGLF4/I ,/O and/O magnesium/O can/O stimulate/O the/O activity/O ./O
The/O Mif1/I 5/I '/I flanking/I region/I contains/O a/O functional/O ER/O stress/O -/O responsive/O element/O which/O is/O sufficient/O for/O induction/O by/O tunicamycin/O ./O
Rigid/O point/O feature/O registration/O using/O mutual/O information/O ./O
Methysergide/O is/O a/O serotonin/O antagonist/O and/O has/O been/O demonstrated/O to/O reduce/O wound/O blood/O flow/O and/O edema/O formation/O ./O
Serum/O leptin/I concentrations/O in/O women/O during/O gonadotropin/I stimulation/O cycles/O ./O
Valuing/O families/O :/O social/O work/O practice/O with/O families/O from/O a/O strengths/O perspective/O ./O
PURPOSE/O :/O A/O two/O -/O generation/O consanguineous/O Pakistani/O family/O with/O autosomal/O recessive/O Leber/O congenital/O amaurosis/O (/O LCA/O ,/O MIM/O 204/O ,/O 000/O )/O and/O keratoconus/O was/O identified/O ./O
Ste18p/I was/O targeted/O to/O the/O plasma/O membrane/O even/O in/O the/O absence/O of/O prenylation/O or/O thioacylation/O ./O
Here/O ,/O we/O show/O that/O IRF/I -/I 1/I is/O degraded/O via/O the/O ubiquitin/I -/O proteasome/O pathway/O ./O
An/O amino/O -/O acid/O sequence/O comparison/O revealed/O that/O Bacillus/I YM55/I -/I 1/I aspartase/I shared/O 71/O %/O homology/O with/O Bacillus/I subtilis/I aspartase/I and/O 49/O %/O with/O Escherichia/O coli/O and/O Pseudomonas/I fluorescens/I aspartases/I ./O
Unique/O to/O this/O system/O ,/O the/O activity/O of/O TraR/I is/O negatively/O modulated/O by/O an/O antiactivator/O called/O TraM/I ./O
As/O assessed/O by/O a/O genetic/O assay/O that/O measures/O AAI/O -/O dependent/O DNA/O binding/O ,/O TraM/I inhibited/O TraR/I function/O before/O and/O after/O the/O transcription/O factor/O had/O bound/O to/O its/O DNA/O recognition/O site/O ./O
Here/O we/O show/O that/O IIIa/O pre/O -/O mRNA/O splicing/O is/O activated/O more/O than/O 200/O -/O fold/O in/O nuclear/O extracts/O prepared/O from/O late/O adenovirus/O -/O infected/O cells/O (/O Ad/O -/O NE/O )/O compared/O to/O uninfected/O HeLa/O cell/O nuclear/O extracts/O (/O HeLa/O -/O NE/O )./O
Inactivation/O of/O Ulp2/I also/O suppresses/O several/O ulp1/I (/I ts/I )/I defects/O ,/O and/O the/O double/O mutant/O accumulates/O far/O fewer/O Smt3/I -/I protein/I conjugates/O than/O either/O single/O mutant/O ./O
Collectively/O ,/O the/O results/O suggest/O that/O ARF/I binding/O to/O Mdm2/I induces/O a/O conformational/O change/O that/O facilitates/O nucleolar/O import/O of/O the/O ARF/I -/O Mdm2/I complex/O and/O p53/I -/O dependent/O cell/O cycle/O arrest/O ./O
Cyclin/I A/I expression/O is/O repressed/O in/O quiescent/O cells/O by/O E2F/I acting/O in/O conjunction/O with/O its/O pocket/O protein/O partners/O Rb/I ,/O p107/I ,/O and/O p130/I ;/O however/O ,/O v/I -/I Jun/I overrides/O this/O control/O ,/O causing/O phosphorylated/O Rb/I and/O proliferation/O -/O specific/O E2F/I -/O p107/I complexes/O to/O persist/O after/O mitogen/O withdrawal/O ./O
D/I -/I cyclin/I -/O cdk/I activity/O is/O required/O for/O Rb/I phosphorylation/O in/O v/I -/I Jun/I -/O transformed/O cells/O ,/O since/O ectopic/O expression/O of/O the/O cdk4/I -/O and/O cdk6/I -/O specific/O inhibitor/O p16/I (/O INK4A/I )/O inhibits/O both/O DNA/O synthesis/O and/O cell/O proliferation/O ./O
CONCLUSION/O :/O A/O valve/O -/O like/O mechanism/O formed/O by/O the/O capsulorhexis/O rim/O partially/O adhered/O to/O the/O IOL/O optic/O can/O occur/O postoperatively/O ./O
The/O protein/O first/O identified/O by/O the/O monoclonal/I antibody/I Q18/I is/O encoded/O by/O a/O gene/O located/O in/O 57A/O on/O polytene/O chromosomes/O and/O has/O been/O consequently/O named/O Hrb57A/I ./O
3/O '/O RNA/O boundary/O experiments/O indicate/O that/O the/O 5/O '/O structure/O reduces/O the/O number/O of/O (/O G/O //O U/O )/O AG/O repeats/O required/O for/O stable/O TRAP/I -/O trp/I leader/O RNA/O association/O ./O
Gene/O silencing/O associated/O with/O repeated/O DNA/O sequences/O has/O been/O reported/O for/O many/O eukaryotes/O ,/O including/O plants/O ./O
The/O AtERF/I genes/I were/O differentially/O regulated/O by/O ethylene/O and/O by/O abiotic/O stress/O conditions/O ,/O such/O as/O wounding/O ,/O cold/O ,/O high/O salinity/O ,/O or/O drought/O ,/O via/O ETHYLENE/I -/I INSENSITIVE2/I (/O EIN2/I )-/O dependent/O or/O -/O independent/O pathways/O ./O
Animals/O received/O a/O dose/O of/O dexamethasone/O (/O 10/O mg/O //O kg/O i/O ./O p/O .)/O prior/O to/O the/O protein/O -/O free/O surfactant/O preparation/O Exosurf/O (/O pure/O phospholipids/O containing/O surfactant/O ,/O Wellcome/O GmbH/O ,/O Burgwedel/O ,/O Germany/O )/O and/O a/O rSP/O -/O C/O based/O surfactant/O ,/O respectively/O ./O
BACKGROUND/O :/O The/O aim/O of/O this/O study/O was/O to/O determine/O the/O response/O rates/O and/O toxicity/O of/O two/O regimens/O containing/O granulocyte/I -/I macrophage/I -/I colony/I stimulating/I factor/I (/O GM/I -/I CSF/I )/O in/O combination/O with/O interleukin/I -/I 2/I (/O IL/I -/I 2/I )/O in/O the/O treatment/O of/O patients/O with/O metastatic/O renal/O cell/O carcinoma/O ./O
We/O show/O ,/O by/O injection/O of/O synthetic/O mRNAs/O ,/O that/O the/O cis/O -/O acting/O sequences/O responsible/O for/O repression/O of/O cyclin/I B1/I mRNA/I reside/O within/O its/O 3/O '/O UTR/O ./O
These/O data/O indicate/O that/O expansion/O of/O the/O dodecamer/O repeat/O located/O in/O the/O proximal/O promoter/O of/O CSTB/I severely/O disrupts/O the/O function/O of/O the/O promoter/O and/O thereby/O reduces/O transcription/O of/O CSTB/I ./O
Thus/O ,/O while/O the/O genomic/O organization/O of/O mHuA/I is/O similar/O to/O the/O neural/O -/O restricted/O members/O of/O the/O Elav/I family/I ,/O the/O promoter/O element/O differs/O substantially/O both/O by/O sequence/O analysis/O and/O transcriptional/O activity/O in/O non/O -/O neural/O cell/O types/O ./O
Analysis/O of/O the/O 5/O '/O end/O of/O the/O mouse/I Elavl1/I (/O mHuA/I )/O gene/O reveals/O a/O transcriptional/O regulatory/O element/O and/O evidence/O for/O conserved/O genomic/O organization/O ./O mHuA/I (/O Elavl1/I )/O belongs/O to/O a/O highly/O conserved/O family/O of/O genes/O encoding/O RNA/O -/O binding/O proteins/O and/O has/O been/O linked/O to/O cell/O growth/O and/O proliferation/O through/O its/O regulation/O of/O mRNA/O stability/O ./O
Electrophoretic/O mobility/O shift/O assays/O revealed/O that/O Sp1/I binds/O to/O two/O different/O regions/O in/O the/O proximal/O promoter/O ,/O a/O typical/O Sp1/I site/I located/O at/O (-/O 38/O ;/O -/O 33/O )/O and/O a/O G/O //O C/O -/O rich/O region/O between/O (-/O 67/O ;/O -/O 62/O )./O
Fgd3/I and/O FGD1/I share/O a/O high/O degree/O of/O sequence/O identity/O that/O spans/O >/O 560/O contiguous/O amino/O acid/O residues/O ./O
Molecular/O cloning/O of/O mouse/I thioredoxin/I reductases/I ./O
The/O HPLC/O method/O involves/O an/O octadecylsilane/O column/O at/O 55/O degrees/O C/O ,/O a/O mixture/O of/O water/O -/O acetonitrile/O -/O orthophosphoric/O acid/O (/O 779/O :/O 220/O :/O 1/O ,/O v/O //O v/O )/O as/O mobile/O phase/O and/O detection/O at/O 226/O nm/O ./O
Eight/O patients/O received/O 1/O ./O 5/O mg/O of/O adefovir/O dipivoxil/O per/O kg/O of/O body/O weight/O ,/O and/O six/O patients/O received/O 3/O ./O 0/O mg/O of/O adefovir/O dipivoxil/O per/O kg/O ./O
CYC2/I encodes/O a/O 24/O -/O kDa/O protein/O that/O has/O sequence/O identity/O to/O the/O Neurospora/I crassa/I PREG1/I and/O the/O S/I ./I cerevisiae/I PHO80/I cyclin/I ./O
To/O determine/O if/O CYC2/I is/O found/O in/O a/O complex/O with/O previously/O identified/O trypanosome/I cdc2/I -/I related/I kinases/I (/O CRKs/I ),/O the/O CYC2/I gene/I was/O fused/O to/O the/O TY/I epitope/I tag/O ,/O integrated/O into/O the/O trypanosome/O genome/O ,/O and/O expressed/O under/O inducible/O control/O ./O
These/O findings/O indicate/O the/O involvement/O of/O Sp1/I and/O an/O Inr/O in/O non/O -/O cell/O -/O specific/O regulation/O and/O a/O Kruppel/I -/I like/I transcription/I factor/I and/O Sp1/I in/O the/O cell/O -/O specific/O regulation/O of/O the/O LTC/I (/I 4/I )/I S/I gene/I ./O
Here/O we/O review/O progress/O to/O date/O in/O this/O area/O ./O
Additionally/O ,/O the/O mouse/O promoter/O contains/O 22/O copies/O of/O a/O CT/O dinucleotide/O repeat/O sequence/O located/O approximately/O 155/O bp/O 5/O '/O to/O exon/O 1/O ./O
The/O newly/O defined/O region/O contains/O an/O intron/O that/O may/O be/O alternatively/O spliced/O and/O seven/O polyadenylation/O signal/O sequences/O ./O
Depleted/O and/O enriched/O U3O8/O standard/O reference/O materials/O were/O used/O to/O calibrate/O the/O system/O ./O
Therefore/O ,/O the/O positive/O cAMP/O control/O of/O the/O hypoxic/O SRP1/I and/O HEM13/I genes/I was/O uncoupled/O from/O the/O HOG/I pathway/O ./O
Most/O likely/O they/O might/O represent/O regulatory/O RNAs/O or/O transcribed/O transposable/O elements/O ./O
This/O paper/O reviews/O the/O middleware/O -/O based/O approach/O adopted/O by/O CEN/O ENV/O 12967/O -/O 1/O and/O the/O specialisation/O necessary/O for/O the/O healthcare/O record/O based/O on/O CEN/O ENV/O 12265/O '/O Electronic/O Healthcare/O Record/O Architecture/O './O
Sequence/O analyses/O of/O sos2/I mutant/I alleles/I reveal/O that/O both/O the/O N/O -/O terminal/O catalytic/O domain/O and/O the/O C/O -/O terminal/O regulatory/O domain/O of/O SOS2/I are/O functionally/O essential/O ./O
A/O mutation/O which/O abrogates/O the/O binding/O of/O these/O factors/O reduces/O Wp/I reporter/I activity/O specifically/O in/O B/O cell/O lines/O ,/O whereas/O a/O mutation/O which/O converts/O the/O site/O to/O a/O consensus/O CREB/I -/I binding/I sequence/I maintains/O wild/O -/O type/O promoter/O function/O ./O
Here/O we/O describe/O the/O cloning/O ,/O tissue/O -/O specific/O expression/O pattern/O ,/O and/O functional/O characterization/O of/O two/O novel/O TEF/I -/I 1/I isoforms/I ,/O TEF/I -/I 1beta/I and/O TEF/I -/I 1gamma/I ./O
Therefore/O the/O binding/O sites/O for/O liver/O -/O enriched/O factors/O ,/O present/O in/O the/O hamster/I CYP7A1/I proximal/I promoter/I in/O close/O vicinity/O and/O conserved/O between/O species/O ,/O constitute/O a/O regulatory/O unit/O important/O for/O basal/O hepatic/O expression/O and/O tissue/O restriction/O of/O the/O action/O of/O hormones/O such/O as/O insulin/I ./O
The/O kinase/O activity/O of/O PfPK6/I is/O sensitive/O to/O CDK/I inhibitors/O such/O as/O olomoucine/O and/O roscovitine/O ./O
Although/O MAP/I (/I mitogen/I -/I activated/I protein/I )/I kinases/I are/O implicated/O in/O cell/O proliferation/O and/O differentiation/O in/O many/O cell/O types/O ,/O the/O role/O of/O MAP/I kinases/I in/O cardiac/O hypertrophy/O remains/O unclear/O ./O
Transfection/O with/O a/O CSF/I -/I 1R/I expression/O plasmid/O permitted/O CSF/I -/I 1/I -/O dependent/O activation/O of/O the/O signalling/O pathway/O targeting/O an/O Ets/I //O AP1/I (/O activator/I protein/I 1/I )/O element/O in/O the/O uPA/I promoter/I that/O has/O been/O shown/O previously/O to/O be/O a/O target/O of/O oncogenic/I ras/I and/O protein/O kinase/O C/O pathways/O ./O
Regulation/O of/O urokinase/I plasminogen/I activator/I gene/I transcription/O in/O the/O RAW264/O murine/O macrophage/O cell/O line/O by/O macrophage/I colony/I -/I stimulating/I factor/I (/O CSF/I -/I 1/I )/O is/O dependent/O upon/O the/O level/O of/O cell/O -/O surface/O receptor/O ./O
Molecule/O (/O s/O )/O secreted/O by/O neuronal/O cultures/O contribute/O to/O this/O induction/O of/O GLT/I -/I 1/I ,/O but/O little/O is/O known/O about/O the/O signaling/O pathways/O mediating/O this/O regulation/O ./O
Coactivation/O of/O endogenous/O or/O exogenous/O G/I (/I q/I )-/I coupled/I receptors/I with/O the/O delta/I -/I opioid/I receptor/I produced/O strong/O stimulations/O of/O PLCbeta/I and/O such/O responses/O could/O be/O partially/O blocked/O by/O pertussis/I toxin/I ./O
Patients/O enrolled/O in/O the/O Integrilin/O to/O Minimize/O Platelet/O Aggregation/O and/O Coronary/O Thrombosis/O -/O II/O (/O IMPACT/O -/O II/O )/O trial/O were/O analyzed/O ./O
The/O Wnt/I signaling/O pathway/O functions/O reiteratively/O during/O animal/O development/O to/O control/O cell/O fate/O decisions/O ./O
This/O mutation/O no/O longer/O repressed/O the/O HPV/O -/O 11/O upstream/O regulatory/O region/O -/O controlled/O reporter/O expression/O ./O
In/O the/O icosahaedral/O MVMi/O capsid/O ,/O this/O sequence/O forms/O the/O carboxy/O end/O of/O the/O amphipathic/O beta/O -/O strand/O I/O (/O betaI/O ),/O and/O all/O its/O basic/O residues/O are/O contiguously/O positioned/O at/O the/O face/O that/O in/O the/O unassembled/O subunit/O would/O be/O exposed/O to/O solvent/O ./O
The/O two/O contiguous/O IGF2/I (/O human/I insulin/I -/I like/I growth/I factor/I II/I )/O and/O H19/I genes/I are/O reciprocally/O imprinted/O in/O both/O human/O and/O mouse/O ./O
The/O asymmetric/O methylation/O was/O associated/O with/O tissue/O -/O specific/O disruption/O of/O H19/I genomic/O imprinting/O in/O fetal/O brain/O ./O
The/O comparison/O of/O the/O expression/O patterns/O of/O the/O known/O Kv4/I family/I members/I shows/O subtype/O specificity/O with/O significant/O overlaps/O ./O
Early/O treatment/O mechanics/O of/O the/O Class/O II/O division/O 2/O malocclusion/O ./O
Preliminary/O use/O of/O the/O Nottingham/O Eczema/O Severity/O Score/O would/O support/O further/O development/O as/O a/O research/O tool/O for/O a/O simple/O assessment/O of/O disease/O severity/O that/O could/O be/O used/O in/O epidemiological/O studies/O ./O
The/O consensus/O highlights/O the/O importance/O of/O residues/O other/O than/O the/O eight/O motifs/O that/O are/O often/O associated/O with/O DEAD/I -/I box/I RNA/I helicases/I ,/O as/O well/O as/O de/O -/O emphasising/O the/O importance/O of/O the/O "/O A/O "/O residue/O within/O the/O "/O DEAD/O "/O motif/O ./O
Advanced/O adenoma/O was/O defined/O as/O an/O adenoma/O larger/O than/O 10/O mm/O or/O an/O adenoma/O of/O any/O size/O with/O villous/O component/O ,/O high/O -/O grade/O dysplasia/O or/O invasive/O carcinoma/O ./O
In/O transient/O assays/O ,/O using/O rice/O suspension/O -/O cultured/O cells/O transformed/O by/O particle/O bombardment/O ,/O we/O showed/O previously/O that/O Oshox1/I can/O transcriptionally/O repress/O the/O activity/O of/O reporter/O gene/O constructs/O with/O upstream/O HD/I -/I Zip/I binding/O sites/O ./O
Results/O of/O two/O -/O hybrid/O assays/O and/O electrophoretic/O mobility/O shift/O assays/O strongly/O suggest/O that/O all/O HD/I -/I Zip/I proteins/I of/O families/O I/O and/O II/O can/O form/O homodimers/O and/O also/O heterodimers/O with/O all/O HD/I -/I Zip/I proteins/I of/O the/O same/O family/O ./O
Among/O mammalian/I HSFs/I ,/O HSF1/I has/O been/O shown/O to/O be/O important/O for/O regulation/O of/O the/O heat/O -/O induced/O stress/O gene/O expression/O ,/O whereas/O the/O function/O of/O HSF2/I in/O stress/O response/O is/O unclear/O ./O
Importantly/O ,/O concomitant/O expression/O of/O constitutive/O activated/O Raf/I and/O V12N38/I Ras/I results/O in/O almost/O complete/O loss/O of/O TTF/I -/I 1/I activity/O ./O
They/O share/O many/O downstream/O targets/O ,/O including/O remodeling/O of/O the/O actin/I cytoskeleton/O ,/O activation/O of/O p70/I (/I S6/I )/I kinase/I and/O c/I -/I jun/I N/I -/I terminal/I kinase/I (/O JNK/I ),/O and/O regulation/O of/O transcription/O and/O cell/O proliferation/O ./O
Expression/O of/O activated/O Cdc42/I results/O in/O the/O translocation/O of/O PKClambda/I from/O the/O nucleus/O into/O the/O cytosol/O ,/O and/O Cdc42/I and/O PKClambda/I colocalize/O at/O the/O plasma/O membrane/O and/O in/O the/O cytoplasm/O ./O
Copyright/O 2000/O Academic/O Press/O ./O
To/O understand/O whether/O Shc/I localization/O in/O membrane/O rafts/O is/O sufficient/O to/O regulate/O Shc/I function/O ,/O we/O constructed/O a/O Shc/I chimera/I containing/O the/O Ras/I membrane/I localization/I motif/I at/O the/O C/O -/O terminus/O ./O
Southern/O blotting/O and/O single/O strand/O conformation/O polymorphism/O analyses/O did/O not/O show/O tumor/O -/O specific/O alterations/O of/O this/O gene/O in/O gliomas/O and/O RT/O -/O PCR/O studies/O showed/O expression/O in/O glioma/O cell/O lines/O ,/O suggesting/O that/O ANOVA/I is/O not/O the/O chromosome/O 19q/O glioma/O tumor/O suppressor/O gene/O ./O
RegA/I is/O a/O positive/O yet/O nonessential/O regulator/O of/O tol/I -/O oprL/I expression/O ./O
Enzyme/I I/I of/O the/O phosphoenolpyruvate/I :/I sugar/I phosphotransferase/I system/O ./O
Based/O on/O these/O data/O ,/O we/O conclude/O that/O transcription/O of/O prgX/I is/O initiated/O from/O the/O Qa/I promoter/I in/O prgQ/I ,/O and/O PrgX/I autoregulates/O its/O transcription/O either/O by/O mediating/O transcriptional/O readthrough/O or/O increasing/O mRNA/O stability/O ./O
It/O was/O established/O that/O intrathecal/O or/O intraperitoneal/O PTFL/O ,/O elevated/O the/O nociceptive/O threshold/O for/O mechanical/O stimuli/O in/O the/O formalin/O test/O in/O rats/O ./O
Molecular/O mimicry/O of/O human/O cytokine/O and/O cytokine/O response/O pathway/O genes/O by/O KSHV/O ./O
Family/O environment/O was/O an/O important/O influence/O on/O interpersonal/O relationships/O ,/O substance/O use/O ,/O and/O social/O support/O ./O
By/O electrophoresis/O mobility/O shift/O assays/O using/O probes/O corresponding/O to/O different/O segments/O of/O the/O putative/O human/I c/I -/I myb/I intron/I 1/I transcription/I pause/I region/I and/O nuclear/O extracts/O from/O myeloid/O leukemia/O HL/O 60/O and/O fibroblast/O WI/O 38/O cells/O ,/O we/O detected/O a/O HL/O -/O 60/O -/O specific/O DNA/O -/O protein/O complex/O with/O a/O 123/O -/O bp/O fragment/O containing/O binding/O sites/O for/O the/O interferon/I regulatory/I factors/I (/O IRFs/I )/O nuclear/O proteins/O ./O
STUDY/O DESIGN/O :/O Fine/O needle/O aspiration/O cytologic/O smears/O from/O 21/O cases/O of/O invasive/O lobular/O carcinoma/O (/O ILC/O )/O of/O breast/O were/O subjected/O to/O detailed/O cytomorphologic/O analysis/O ./O
Electrophile/O Response/O Elements/O (/O EpREs/O ),/O located/O in/O 5/O '-/O flanking/O sequences/O of/O both/O the/O GCSh/I and/O GCSl/I subunit/I genes/I ,/O are/O hypothesized/O to/O at/O least/O partially/O mediate/O gene/O induction/O following/O xenobiotic/O exposure/O ./O
A/O new/O technique/O to/O create/O an/O artificial/O stenosis/O in/O the/O native/O LAD/O using/O a/O hemoclip/O ./O
Dll3/I is/O mutated/O in/O the/O X/O -/O ray/O -/O induced/O mouse/I mutant/I pudgy/I (/O pu/I ),/O causing/O a/O variety/O of/O vertebrocostal/O defects/O similar/O to/O SD/O phenotypes/O ./O
Schlegel/O ,/O J/O ./O
TbRAB31/I behaviour/O was/O also/O studied/O during/O the/O cell/O cycle/O ;/O TbRAB31/I always/O localised/O to/O a/O discrete/O structure/O that/O duplicated/O very/O early/O in/O mitosis/O and/O relocated/O to/O daughter/O cells/O in/O a/O coordinate/O manner/O with/O the/O basal/O body/O and/O kinetoplast/O ,/O suggesting/O the/O involvement/O of/O microtubules/O ./O
The/O early/O dg/O ./O of/O rejection/O and/O especially/O acute/O rejection/O ,/O it/O '/O s/O adequate/O management/O ,/O decreased/O risk/O for/O the/O future/O chronic/O rejection/O nephropathy/O ./O
Invertases/I are/O responsible/O for/O the/O breakdown/O of/O sucrose/O to/O fructose/O and/O glucose/O ./O
To/O investigate/O the/O molecular/O mechanisms/O of/O this/O Tax/I -/O mediated/O inhibition/O ,/O we/O analyzed/O its/O effect/O on/O the/O transcriptional/O activity/O of/O the/O myogenic/O MyoD/I protein/I ,/O which/O was/O used/O as/O a/O paradigm/O of/O bHLH/I factors/I ./O
The/O human/I T/I cell/I leukemia/I //I lymphotropic/I virus/I type/I 1/I Tax/I protein/I represses/O MyoD/I -/O dependent/O transcription/O by/O inhibiting/O MyoD/I -/O binding/O to/O the/O KIX/I domain/I of/O p300/I ./O
Phosphorylation/O and/O spindle/O pole/O body/O localization/O of/O the/O Cdc15p/I mitotic/I regulatory/I protein/I kinase/I in/I budding/I yeast/I ./O
Thus/O ,/O both/O the/O hyperplasia/O and/O thrombotic/O complications/O which/O often/O follow/O stenting/O might/O be/O minimized/O by/O employing/O gold/O stents/O ,/O which/O have/O a/O greater/O capacity/O than/O steel/O in/O supporting/O a/O functional/O neo/O -/O endothelium/O ./O
The/O cell/O cycle/O and/O transcriptional/O defects/O caused/O by/O taf17/I (/O slm7/I -/I 1/I )/O are/O consistent/O with/O the/O role/O of/O TAF/I (/I II/I )/I s/I as/O modulators/O of/O transcriptional/O activation/O and/O may/O reflect/O a/O role/O for/O TAF17/I in/O regulating/O activation/O by/O SBF/I and/O MBF/I ./O
Extracellular/I -/I regulated/I kinase/I (/O ERK/I )/O activation/O and/O molecular/O coupling/O of/O the/O adaptor/O proteins/O p130/I Crk/I -/I associated/I substrate/I (/O CAS/I )/O and/O c/I -/I CrkII/I (/O Crk/I )/O represent/O two/O distinct/O pathways/O that/O induce/O cell/O invasion/O and/O protect/O cells/O from/O apoptosis/O in/O a/O three/O -/O dimensional/O collagen/I matrix/O ./O
Proteolysis/O of/O Mbp1/I and/O Swi4/I DNA/I -/I protein/I complexes/I has/O revealed/O the/O extent/O of/O these/O sequences/O ,/O and/O C/O -/O terminally/O extended/O molecules/O with/O substantially/O enhanced/O DNA/O binding/O activity/O compared/O to/O the/O core/O domains/O alone/O have/O been/O produced/O ./O
The/O evolution/O of/O the/O CCR5/I cis/I -/I regulatory/I region/I versus/O the/O open/O reading/O frame/O as/O well/O as/O among/O different/O domains/O of/O the/O open/O reading/O frame/O differed/O from/O one/O another/O ./O
These/O results/O indicate/O that/O residue/O 266/O serves/O as/O a/O "/O protein/O sensor/O "/O of/O altered/O minor/O groove/O interactions/O and/O identifies/O which/O base/O pair/O interactions/O are/O altered/O by/O these/O lesions/O ./O
The/O recombinant/O enzymes/O exist/O as/O monomers/O ./O
A/O pathway/O for/O regulation/O of/O B/I lymphocyte/I antigen/I receptor/I -/O induced/O calcium/O flux/O ./O
We/O now/O describe/O a/O second/O RIM/I protein/I ,/O called/O RIM2/I ,/O that/O is/O highly/O homologous/O to/O RIM1/I and/O also/O expressed/O primarily/O in/O brain/O ./O
Inhibitor/I -/I 1/I (/O I/I -/I 1/I )/O and/O inhibitor/I -/I 2/I (/O I/I -/I 2/I )/O selectively/O inhibit/O type/I 1/I protein/I serine/I //I threonine/I phosphatases/I (/O PP1/I )./O
Scanning/O mutations/O throughout/O the/O AC/O element/O interfered/O with/O induction/O but/O allowed/O us/O to/O define/O five/O overlapping/O sites/O for/O regulatory/O factors/O in/O AC/O and/O to/O design/O probes/O binding/O just/O one/O or/O two/O factors/O ./O
The/O substrates/O for/O glycan/O synthesis/O in/O the/O lumen/O of/O the/O Golgi/O are/O nucleotide/O sugars/O that/O must/O be/O transported/O from/O the/O cytosol/O by/O specific/O membrane/O -/O bound/O transporters/O ./O
Synaptic/O targeting/O of/O the/O postsynaptic/I density/I protein/I PSD/I -/I 95/I mediated/O by/O a/O tyrosine/O -/O based/O trafficking/O signal/O ./O
(/O 1998/O )/O J/O ./O
Bites/O by/O two/O species/O of/O adders/O (/O Vipera/O aspis/O and/O Vipera/O berus/O )/O can/O lead/O to/O extensive/O swelling/O with/O multiorgan/O failure/O ./O
Both/O normal/O and/O transforming/O PCPH/I proteins/I have/O guanosine/I diphosphatase/I activity/O but/O only/O the/O oncoprotein/O cooperates/O with/O Ras/I in/O activating/O extracellular/I signal/I -/I regulated/I kinase/I ERK1/I ./O
These/O results/O indicate/O that/O virulence/O -/O associated/O genes/O and/O their/O overall/O chromosomal/O arrangement/O are/O relatively/O well/O conserved/O between/O B/O ./O henselae/O and/O other/O gram/O -/O negative/O bacteria/O such/O as/O A/O ./O tumefaciens/O ./O
An/O important/O mechanism/O by/O which/O the/O tumor/O suppressor/O p53/I maintains/O genomic/O stability/O is/O to/O induce/O cell/O cycle/O arrest/O through/O activation/O of/O the/O cyclin/I -/I dependent/I kinase/I inhibitor/O p21/I (/O WAF1/I //O Cip1/I )/O gene/O ./O
Paxillin/I acts/O as/O an/O adaptor/O molecule/O in/O integrin/I signaling/O ./O
Thus/O ,/O growth/O factor/O activation/O of/O ER/I can/O mediate/O transactivation/O vs/O ER/I //O Sp1/I binding/O to/O GC/O -/O rich/O sites/O and/O represents/O a/O novel/O pathway/O for/O ligand/O -/O independent/O ER/I action/O ./O
Furthermore/O ,/O analysis/O of/O deletion/O promoter/O -/O reporter/O constructs/O found/O that/O the/O basal/O activity/O of/O P2/O resided/O in/O the/O proximal/O region/O of/O P2/O ./O
RESULTS/O :/O Auditory/O thresholds/O collected/O during/O audiometric/O tests/O increased/O gradually/O in/O proportion/O with/O age/O ,/O especially/O in/O the/O hypertensive/O group/O (/O p/O /O or/O =/O 800/O )/O were/O asked/O to/O complete/O a/O questionnaire/O ,/O which/O was/O computerized/O ./O
Copyright/O 2000/O Academic/O Press/O ./O
Viral/O cell/O -/O to/O -/O cell/O movement/O of/O PVX/I CP/I mutant/I was/O complemented/O in/O Nicotiana/O tabacum/O cv/O ./O
Induction/O of/O CD86/I expression/O by/O stimulation/O of/O U937/O cells/O with/O IFN/I -/I gamma/I revealed/O the/O presence/O of/O two/O functional/O GAS/I (/O gamma/I -/I interferon/I activation/I site/I )/O elements/O ./O
Significantly/O ,/O two/O proximal/O GATA/I -/I 1/I -/I binding/I sites/I (-/O 118/O /-/O 113/O and/O -/O 98/O /-/O 93/O )/O and/O a/O region/O located/O within/O -/O 518/O to/O -/O 315bp/O of/O the/O mouse/I ALAS2/I promoter/I were/O essential/O for/O transcriptional/O activation/O during/O chemically/O induced/O differentiation/O of/O MEL/O cells/O ,/O implying/O their/O importance/O in/O conferring/O erythroid/O specificity/O to/O the/O ALAS2/I transcriptional/O activation/O ./O
SNAP/I -/I 23/I plays/O an/O important/O role/O in/O the/O regulation/O of/O vesicle/O trafficking/O in/O mammalian/O cells/O ./O
The/O HMG/I domain/I of/O both/O HMG20/I proteins/I is/O most/O similar/O to/O that/O of/O yeast/I NHP6A/I (/O 38/O %/O to/O 42/O %)./O
IgM/I and/O IgG/I anti/I A/I and/O anti/I B/I antibody/I status/O of/O 100/O antenatal/O O/O group/O mothers/O (/O who/O had/O non/O O/O group/O husbands/O )/O were/O studied/O ./O
In/O an/O attempt/O to/O understand/O Wee1/I regulation/O during/O cell/O cycle/O ,/O yeast/O two/O -/O hybrid/O screening/O was/O used/O to/O identify/O Wee1/O -/O binding/O protein/O (/O s/O )./O
Retroviral/O transduction/O of/O T/I //I T/I (/I L/I )/I causes/O a/O rapidly/O fatal/O myeloproliferative/O disease/O in/O a/O murine/O bone/O marrow/O transplant/O (/O BMT/O )/O model/O ,/O whereas/O T/I //I T/I (/I F/I )/I causes/O a/O long/O -/O latency/O ,/O pre/O -/O B/O -/O cell/O lymphoblastic/O lymphoma/O ./O
Ab/O -/O MLV/O strains/O expressing/O P70/I //O S2/I failed/O to/O transform/O NIH/O 3T3/O cells/O and/O demonstrated/O a/O greatly/O reduced/O capacity/O to/O mediate/O signaling/O events/O associated/O with/O the/O Ras/I -/O dependent/O mitogen/I -/I activated/I protein/I (/I MAP/I )/I kinase/I pathway/O ./O
The/O codon/O usage/O is/O particularly/O marked/O for/O the/O gag/I ,/O pol/I ,/O and/O env/I genes/I ./O
The/O p53/I -/I homolog/I p73beta/I also/O activated/O the/O PIG3/I promoter/I ,/O but/O in/O contrast/O to/O p53/I ,/O the/O proline/O -/O rich/O domain/O of/O p73beta/I (/I residues/I 81/I -/I 113/I )/I was/O dispensable/O to/O induce/O the/O PIG3/I promoter/I ./O
Results/O from/O transient/O assays/O using/O these/O mutants/O showed/O that/O the/O DE1/O received/O signals/O from/O phytochromes/I A/I and/I B/I ,/O demonstrating/O that/O this/O element/O is/O indeed/O a/O light/O -/O responsive/O element/O ./O
Co/O -/O immunoprecipitation/O and/O DNA/O affinity/O chromatography/O prove/O that/O Sp1/I heterodimerizes/O with/O ZBP/I -/I 89/I when/O bound/O to/O the/O silencer/O element/O to/O yield/O a/O DNA/O -/O protein/O complex/O whose/O mobility/O is/O indistinguishable/O from/O that/O displayed/O by/O HeLa/O nuclear/O extract/O in/O band/O shift/O assays/O ./O
The/O ZNF274/I gene/I is/O mapped/O distal/O to/O marker/O RP/O S28/O 1/O in/O the/O human/O chromosome/O 19qter/O region/O ,/O by/O RH/O mapping/O ./O
The/O C/I -/I terminal/I Cdk2/I truncations/O ,/O however/O ,/O were/O non/O -/O functional/O in/O these/O strains/O and/O thus/O dependent/O for/O activity/O on/O the/O pho85/I coding/I region/I which/O remained/O in/O the/O mutant/I pho85/I ::/O HIS3/I chromosomal/I locus/I ./O
We/O report/O here/O on/O the/O molecular/O nature/O of/O an/O EMS/O -/O induced/O mutant/O ,/O mn1/I -/I 89/I ,/O a/O leaky/O semidominant/O allele/O of/O the/O Miniature1/I (/O Mn1/I )/O seed/O locus/O that/O encodes/O a/O seed/I -/I specific/I cell/I wall/I invertase/I ,/O INCW2/I ./O
We/O conclude/O that/O ,/O both/O in/O atrial/O myocytes/O and/O in/O Xenopus/O oocytes/O ,/O beta/O -/O adrenergic/O stimulation/O potentiates/O the/O ACh/O -/O evoked/O GIRK/I channels/I via/O a/O pathway/O that/O involves/O PKA/I -/O catalyzed/O phosphorylation/O downstream/O from/O beta/I (/I 2/I )/I AR/I ./O
Slap/I negatively/O regulates/O Src/I mitogenic/O function/O but/O does/O not/O revert/O Src/I -/O induced/O cell/O morphology/O changes/O ./O
Identification/O of/O a/O novel/O E2F3/I product/I suggests/O a/O mechanism/O for/O determining/O specificity/O of/O repression/O by/O Rb/I proteins/I ./O
In/O DNase/I I/I footprinting/O protection/O analysis/O ,/O both/O SFRE/I and/O ERE/O regions/O were/O protected/O by/O glutathione/I S/I -/I transferase/I -/O ERRalpha1/I fusion/O protein/O ./O
Overexpressing/O the/O coactivator/O ,/O SRC1a/I or/O GRIP1/I ,/O further/O enhances/O ERRalpha1/I -/O induced/O transcriptional/O activity/O ./O
Estrogen/I receptor/I -/I related/I receptor/I alpha/I 1/I interacts/O with/O coactivator/O and/O constitutively/O activates/O the/O estrogen/O response/O elements/O of/O the/O human/I lactoferrin/I gene/I ./O
We/O examine/O current/O models/O of/O the/O effects/O of/O aging/O on/O mean/O response/O time/O and/O show/O how/O they/O might/O be/O reinterpreted/O ./O
The/O effects/O of/O these/O mutations/O on/O protein/O function/O require/O further/O examination/O ./O
The/O median/O levels/O of/O particles/O with/O 50/O %/O cut/O -/O off/O aerodynamic/O diameters/O of/O 10/O (/O PM10/O )/O and/O 2/O ./O 5/O microm/O (/O PM2/O ./O 5/O )/O were/O 170/O (/O range/O 103/O -/O 613/O )/O and/O 95/O (/O range/O 61/O -/O 218/O )/O micro/O x/O m/O -/O 3/O ,/O respectively/O ./O
Kaposi/O '/O s/O sarcoma/O -/O associated/O herpesvirus/O viral/I interferon/I regulatory/I factor/I confers/O resistance/O to/O the/O antiproliferative/O effect/O of/O interferon/I -/I alpha/I ./O
Specific/O and/O heritable/O genetic/O interference/O by/O double/O -/O stranded/O RNA/O in/O Arabidopsis/O thaliana/O ./O
Comparison/O of/O sequences/O from/O -/O 215/O to/O +/O 1/O bp/O identified/O consensus/O binding/O sites/O for/O the/O homeodomain/I transcription/I factor/I thyroid/I transcription/I factor/I -/I 1/I (/O TTF/I -/I 1/I )./O
Two/O additional/O cis/O -/O acting/O sequences/O ,/O conserved/O in/O both/O the/O region/O 1/O and/O 3/O promoters/O ,/O were/O identified/O ,/O suggesting/O a/O role/O for/O these/O sequences/O in/O the/O coordinate/O regulation/O of/O transcription/O from/O these/O promoters/O ./O
Purple/O photosynthetic/O bacteria/O are/O capable/O of/O generating/O cellular/O energy/O from/O several/O sources/O ,/O including/O photosynthesis/O ,/O respiration/O ,/O and/O H/O (/O 2/O )/O oxidation/O ./O
An/O analysis/O of/O synthetic/O peptides/O revealed/O a/O minimal/O CTD/O sequence/O that/O is/O sufficient/O to/O bind/O to/O the/O second/O Rsp5/I WW/I domain/I (/O Rsp5/I WW2/I )/O in/O vitro/O and/O in/O yeast/O two/O -/O hybrid/O assays/O ./O
Furthermore/O ,/O bone/O marrow/O -/O derived/O macrophages/O from/O LAT/I -/O deficient/O mice/O displayed/O reduced/O phagocytic/O efficiency/O in/O comparison/O to/O the/O macrophages/O from/O wild/O -/O type/O mice/O ./O
T1/O -/O weighted/O MRI/O on/O the/O 49th/O postoperative/O day/O demonstrated/O bilateral/O and/O symmetrical/O hyperintense/O lesions/O in/O the/O globus/O pallidus/O ./O
The/O method/O is/O applied/O to/O determine/O aberration/O constants/O of/O a/O CM300/O FEG/O //O UT/O microscope/O with/O correction/O of/O the/O three/O -/O fold/O astigmatism/O ./O
The/O interaction/O does/O not/O depend/O on/O the/O presence/O of/O the/O correct/O amino/O -/O terminal/O DNA/O binding/O domain/O or/O the/O amino/O acid/O sequences/O between/O the/O DNA/O binding/O domain/O and/O the/O last/O ten/O amino/O acids/O ./O
METHOD/O :/O The/O sample/O of/O subjects/O was/O drawn/O from/O the/O Suffolk/O County/O Mental/O Health/O Project/O ,/O a/O longitudinal/O epidemiologic/O study/O of/O first/O -/O hospitalized/O subjects/O with/O psychotic/O disorders/O ;/O the/O present/O study/O focused/O on/O patients/O with/O schizophrenic/O disorders/O ./O
Marrow/O dysplasia/O is/O a/O major/O characteristic/O of/O patients/O with/O myelodysplastic/O syndrome/O (/O MDS/O ),/O along/O with/O marrow/O blastosis/O ,/O cytopenia/O and/O cytogenetic/O anomalies/O ./O
Eight/O of/O the/O non/O -/O acceptable/O inlays/O //O onlays/O and/O five/O of/O the/O direct/O restorations/O were/O replaced/O ,/O while/O the/O other/O ones/O were/O repaired/O with/O resin/O composite/O ./O
How/O plants/O respond/O to/O attack/O by/O the/O range/O of/O herbivores/O and/O pathogens/O that/O confront/O them/O in/O the/O field/O is/O the/O subject/O of/O considerable/O research/O by/O both/O molecular/O biologists/O and/O ecologists/O ./O
CONCLUSION/O :/O The/O probability/O of/O cardiopulmonary/O complications/O increases/O significantly/O when/O patients/O develop/O class/O 1/O HELLP/O syndrome/O ./O
The/O rate/O -/O limiting/O step/O for/O telomerase/I activity/O seems/O to/O be/O the/O expression/O of/O the/O catalytic/O subunit/O of/O the/O enzyme/O ,/O encoded/O by/O the/O human/I telomerase/I reverse/I transcriptase/I (/O hTERT/I )/O gene/O ./O
In/O the/O control/O group/O ,/O platelet/O markers/O increased/O 1/O h/O after/O surgery/O ./O
However/O ,/O the/O element/O proximal/O to/O the/O transcription/O start/O site/O is/O dependent/O on/O the/O SRE/O -/O 1/O ./O
AMDA/O white/O paper/O identifies/O ways/O to/O improve/O pharmaceutical/O care/O in/O SNFs/O ./O
Since/O proteins/O containing/O TPR/O elements/O are/O typically/O involved/O in/O multiple/O protein/O -/O protein/O interactions/O ,/O we/O suggest/O that/O the/O 102kD/O protein/O interacts/O within/O the/O tri/O -/O snRNP/O with/O both/O the/O U5/I and/O U4/I //O U6/I snRNPs/O ,/O thus/O bridging/O the/O two/O particles/O ./O
Antibodies/O raised/O against/O a/O C/O -/O terminal/O portion/O of/O Sec31A/I co/O -/O precipitate/O Sec13/I and/O inhibit/O ER/O -/O Golgi/O transport/O of/O temperature/O -/O arrested/O vesicular/O stomatitis/I G/I protein/I in/O a/O semi/O -/O intact/O cell/O assay/O ./O
Regulation/O of/O mitochondrial/O single/O -/O stranded/O DNA/O -/O binding/O protein/O gene/O expression/O links/O nuclear/O and/O mitochondrial/O DNA/O replication/O in/O drosophila/O ./O
Genetic/O and/O molecular/O complexity/O of/O the/O position/O effect/O variegation/O modifier/O mod/I (/O mdg4/I )/O in/O Drosophila/O ./O mod/I (/O mdg4/I ),/O also/O known/O as/O E/I (/I var/I )/I 3/I -/I 93D/I ,/O is/O involved/O in/O a/O variety/O of/O processes/O ,/O such/O as/O gene/O silencing/O in/O position/O effect/O variegation/O (/O PEV/O ),/O the/O control/O of/O gypsy/I insulator/I sequences/I ,/O regulation/O of/O homeotic/I gene/I expression/O ,/O and/O programmed/O cell/O death/O ./O
They/O are/O present/O in/O many/O kinds/O of/O living/O things/O ,/O but/O their/O functions/O ,/O especially/O those/O in/O humans/O ,/O are/O unclear/O ./O
This/O tendency/O is/O likely/O due/O to/O the/O biased/O nucleotide/O composition/O of/O the/O asparagus/O genome/O ,/O rather/O than/O to/O the/O translational/O selection/O for/O specific/O codons/O ./O
Transduction/O of/O the/O human/O leukemic/O cell/O line/O K562/O showed/O that/O viral/O MRP1/I -/O PG13/O supernatants/O routinely/O transfer/O the/O MRP1/I gene/I to/O approximately/O 35/O %/O of/O target/O K562/O cells/O ,/O of/O which/O at/O least/O one/O third/O are/O capable/O of/O proliferating/O in/O the/O presence/O of/O otherwise/O toxic/O concentrations/O of/O etoposide/O ./O
Regulation/O of/O pituitary/O vasopressin/I V1b/I receptors/I plays/O a/O critical/O role/O in/O regulating/O pituitary/I adrenocorticotropic/I hormone/I (/O ACTH/I )/O secretion/O during/O adaptation/O to/O stress/O ./O
Identification/O of/O an/O AfsA/I homologue/I (/O BarX/I )/O from/O Streptomyces/O virginiae/O as/O a/O pleiotropic/O regulator/O controlling/O autoregulator/O biosynthesis/O ,/O virginiamycin/O biosynthesis/O and/O virginiamycin/O M1/O resistance/O ./O
Because/O the/O mutant/O defective/O in/O DNA/O binding/O also/O fails/O to/O stimulate/O Abf1/I ARS1/O DNA/O -/O binding/O activity/O ,/O our/O results/O suggest/O that/O Cdc6/I DNA/O -/O binding/O activity/O may/O play/O a/O pivotal/O role/O in/O the/O initiation/O of/O DNA/O replication/O ./O
Given/O its/O relative/O longevity/O on/O the/O Web/O ,/O TIE/O researchers/O have/O been/O in/O a/O unique/O position/O to/O observe/O trends/O in/O telemedicine/O ./O
The/O structural/O study/O of/O peptides/O belonging/O to/O the/O terminal/O domains/O of/O histone/I H1/I can/O be/O considered/O as/O a/O step/O toward/O the/O understanding/O of/O the/O function/O of/O H1/I in/O chromatin/O ./O
The/O recovery/O rates/O for/O the/O MB/O //O BacT/O ,/O MGIT/O 960/O ,/O and/O solid/O media/O were/O 91/O ./O 6/O ,/O 87/O ./O 4/O ,/O and/O 54/O ./O 7/O %,/O respectively/O ,/O for/O all/O mycobacteria/O ;/O the/O recovery/O rates/O were/O 93/O ./O 6/O ,/O 88/O ./O 9/O ,/O and/O 63/O ./O 4/O %,/O respectively/O ,/O for/O M/O ./O tuberculosis/O complex/O alone/O ,/O and/O 87/O ./O 5/O ,/O 84/O ./O 4/O ,/O and/O 37/O ./O 5/O %,/O respectively/O ,/O for/O all/O nontuberculous/O mycobacteria/O ./O
Cerebral/O vasculitis/O secondary/O to/O Crohn/O '/O s/O disease/O seems/O to/O be/O a/O very/O rare/O phenomenon/O ./O
SELECTION/O CRITERIA/O :/O Randomised/O and/O possibly/O randomised/O trials/O using/O acupuncture/O to/O treat/O asthma/O and/O asthma/O -/O like/O symptoms/O ./O
SELECTION/O CRITERIA/O :/O Randomised/O trials/O comparing/O children/O undergoing/O systematic/O therapy/O focusing/O on/O the/O family/O in/O conjunction/O with/O asthma/O medication/O ,/O with/O children/O taking/O asthma/O medication/O only/O ./O
To/O test/O the/O hypothesis/O that/O progestin/O -/O mediated/O increases/O in/O resting/O core/O temperature/O and/O the/O core/O temperature/O threshold/O for/O sweating/O onset/O are/O counteracted/O by/O estrogen/O ,/O we/O studied/O eight/O women/O (/O 24/O +/-/O 2/O yr/O )/O at/O 27/O degrees/O C/O rest/O ,/O during/O 20/O min/O of/O passive/O heating/O (/O 35/O degrees/O C/O ),/O and/O during/O 40/O min/O of/O exercise/O at/O 35/O degrees/O C/O ./O
The/O models/O were/O tested/O by/O studying/O their/O response/O to/O disturbances/O of/O the/O afferent/O signal/O from/O the/O bladder/O ./O
Our/O data/O show/O also/O that/O phagocytic/O killing/O of/O meningococci/O is/O probably/O a/O more/O consistent/O assay/O than/O antibody/O titer/O levels/O for/O antimeningococcal/O immunity/O ,/O especially/O in/O LCC/O -/O deficient/O patients/O ./O
These/O studies/O suggest/O an/O additional/O component/O or/O cellular/O environment/O is/O required/O for/O SPRK/I activation/O by/O Cdc42/I ./O
M/O ./O
Jkappa/I DNA/I -/I binding/I sites/I were/O not/O required/O for/O this/O activation/O ,/O and/O a/O mutant/I EBNA/I -/I 3C/I protein/I unable/O to/O bind/O Jkappa/I activated/O transcription/O as/O efficiently/O as/O wild/I -/I type/I EBNA/I -/I 3C/I ,/O indicating/O that/O EBNA/I -/I 3C/I can/O regulate/O transcription/O through/O a/O mechanism/O that/O is/O independent/O of/O Jkappa/I ./O
Thus/O ,/O both/O YY1/I and/O CDP/I appear/O to/O be/O negative/O regulators/O of/O the/O differentiation/O -/O induced/O HPV/I -/I 6/I E1/I promoter/I and/O thereby/O the/O HPV/O life/O cycle/O ./O
Sequential/O cleavage/O by/O metallopeptidases/I and/O proteasomes/O is/O involved/O in/O processing/O HIV/I -/I 1/I ENV/I epitope/I for/O endogenous/O MHC/I class/I I/I antigen/I presentation/O ./O
Cloning/O and/O characterization/O of/O human/I Lnk/I ,/O an/O adaptor/O protein/O with/O pleckstrin/I homology/O and/O Src/I homology/I 2/I domains/I that/O can/O inhibit/O T/O cell/O activation/O ./O
Vancomycin/O data/O were/O analyzed/O according/O to/O a/O one/O -/O compartment/O open/O model/O with/O use/O of/O NONMEM/O population/O pharmacokinetic/O software/O ./O
Finally/O ,/O Cas/I existed/O mainly/O in/O cytosol/O and/O membrane/O cytoskeleton/O fractions/O in/O the/O resting/O state/O ,/O and/O remained/O unchanged/O during/O platelet/O aggregation/O ,/O when/O FAK/I translocated/O to/O the/O cytoskeletal/O fraction/O ./O
We/O also/O show/O that/O p65/I binds/O to/O these/O targets/O with/O almost/O equal/O affinity/O and/O that/O different/O residues/O have/O variable/O roles/O in/O binding/O different/O kappaB/I targets/I ./O
Transcriptional/O regulation/O of/O the/O yeast/I PHO8/I promoter/I in/O comparison/O to/O the/O coregulated/O PHO5/I promoter/I ./O
The/O Siglecs/I are/O a/O subfamily/O of/O I/I -/I type/I lectins/I (/O immunoglobulin/I superfamily/I proteins/I that/O bind/O sugars/O )/O that/O specifically/O recognize/O sialic/O acids/O ./O
Our/O data/O provide/O a/O biochemical/O explanation/O for/O the/O similarity/O in/O phenotype/O between/O A/O -/O T/O and/O NBS/O ./O
PATIENTS/O OR/O OTHER/O PARTICIPANTS/O :/O Twenty/O children/O met/O the/O criteria/O for/O being/O learning/O disabled/O ./O
Update/O on/O maternal/O -/O fetal/O infections/O by/O hepatitis/O C/O ,/O HIV/O and/O cytomegalovirus/O
In/O the/O present/O study/O ,/O we/O characterized/O cis/O -/O elements/O of/O the/O human/I PCI/I gene/I required/O for/O expression/O in/O the/O hepatoma/O -/O derived/O cell/O line/O ,/O HepG2/O cells/O ,/O and/O also/O evaluated/O rat/I PCI/I mRNA/I expression/O ,/O particularly/O on/O the/O effect/O of/O androgen/O in/O rat/O reproductive/O tissues/O ./O
In/O the/O study/O on/O PCI/I mRNA/I expression/O in/O the/O reproductive/O organs/O ,/O we/O first/O cloned/O rat/I PCI/I cDNA/I and/O then/O evaluated/O the/O effect/O of/O androgen/O on/O the/O PCI/I mRNA/I expression/O ./O
To/O illustrate/O its/O performance/O ,/O measurements/O of/O photoluminescence/O in/O GaAs/O //O AlGaAs/O heterostructures/O are/O presented/O ./O
The/O stoichiometry/O of/O the/O complexes/O formed/O with/O the/O dodeca/O -/O satellite/O C/O strand/O suggests/O that/O ,/O in/O DDP1/I ,/O the/O 15/O consecutive/O KH/O domains/O are/O organized/O such/O that/O they/O define/O two/O nucleic/O acid/O binding/O surfaces/O ./O
Mutational/O analysis/O of/O mammalian/I translation/I initiation/I factor/I 5/I (/O eIF5/I ):/O role/O of/O interaction/O between/O the/O beta/O subunit/O of/O eIF2/I and/O eIF5/I in/O eIF5/I function/O in/O vitro/O and/O in/O vivo/O ./O
Much/O evidence/O indicates/O that/O p38/I is/O an/O activator/O of/O MyoD/I :/O (/O i/O )/O p38/I kinase/I activity/O is/O required/O for/O the/O expression/O of/O MyoD/I -/O responsive/O genes/O ,/O (/O ii/O )/O enforced/O induction/O of/O p38/I stimulates/O the/O transcriptional/O activity/O of/O a/O Gal4/I -/O MyoD/I fusion/O protein/O and/O allows/O efficient/O activation/O of/O chromatin/O -/O integrated/O reporters/O by/O MyoD/I ,/O and/O (/O iii/O )/O MyoD/I -/O dependent/O myogenic/O conversion/O is/O reduced/O in/O mouse/O embryonic/O fibroblasts/O derived/O from/O p38alpha/I (-/-)/I embryos/O ./O
This/O activity/O is/O stimulated/O by/O complex/O formation/O with/O the/O other/O eIF2B/I subunits/I ./O
Our/O analysis/O of/O nonsense/O mutations/O indicates/O that/O the/O C/O terminus/O of/O eIF2Bepsilon/I (/I residues/I 518/I to/I 712/I )/I is/O required/O for/O both/O catalytic/O activity/O and/O interaction/O with/O eIF2/I ./O
In/O contrast/O ,/O mutations/O affecting/O the/O other/O two/O Nim1p/I -/I related/I kinases/I in/O S/O ./O cerevisiae/O ,/O Hsl1p/I and/O Kcc4p/I ,/O produce/O no/O detectable/O effect/O on/O septin/I organization/O ./O
CONCLUSIONS/O :/O Physiologic/O pacing/O provides/O little/O benefit/O over/O ventricular/O pacing/O for/O the/O prevention/O of/O stroke/O or/O death/O due/O to/O cardiovascular/O causes/O ./O
Among/O non/O -/O cirrhotics/O ,/O lack/O of/O portal/O vein/O visualisation/O had/O a/O 90/O %/O sensitivity/O ,/O 88/O %/O specificity/O ,/O 94/O %/O negative/O predictive/O value/O ,/O and/O 83/O %/O positive/O predictive/O value/O in/O the/O diagnosis/O of/O pre/O -/O sinusoidal/O portal/O hypertension/O ./O
D5/I //I D1/I (/I CT/I )/I or/O D5/I //I D1D/I (/I CT/I )/I tail/O substitution/O mutants/O displayed/O a/O rank/O order/O of/O potency/O and/O agonist/O affinities/O virtually/O mimicking/O wild/I -/I type/I (/I wt/I )/I D1/I receptors/I ,/O as/O indexed/O by/O both/O ligand/O binding/O and/O dopamine/O -/O stimulated/O cAMP/O accumulation/O assays/O ,/O and/O ,/O similar/O to/O wt/O D1/I receptors/I ,/O did/O not/O exhibit/O receptor/O constitutive/O activity/O or/O responsiveness/O to/O inverse/O agonists/O ./O
Modeling/O also/O revealed/O a/O very/O hydrophobic/O surface/O due/O to/O the/O absence/O of/O H12/O ,/O exposing/O residues/O from/O H3/O ,/O loop/O 3/O -/O 4/O ,/O H4/O ,/O and/O H11/O ./O
The/O serine/I -/I threonine/I kinase/I gene/I is/O likely/O functional/O ,/O whereas/O the/O zinc/O finger/O motif/O is/O likely/O nonfunctional/O ./O
Stat/I activation/O in/O response/O to/O GH/I and/O IL/I -/I 6/I was/O determined/O by/O reporter/O gene/O induction/O ./O
HFA/O 134a/O had/O a/O greater/O tendency/O to/O take/O up/O moisture/O from/O the/O environment/O than/O did/O HFA/O 227/O ./O
RESULTS/O :/O Abnormal/O color/O perception/O was/O found/O in/O 32/O %/O of/O the/O epilepsy/O patients/O treated/O with/O vigabatrin/O monotherapy/O and/O 28/O %/O of/O the/O epilepsy/O patients/O treated/O with/O carbamazepine/O monotherapy/O ./O
In/O the/O SPP2/O screening/O test/O ,/O a/O few/O plates/O were/O not/O seen/O in/O both/O groups/O ./O
Mitogen/I -/I activated/I protein/I (/I MAP/I )/I kinase/I phosphatase/I -/I 3/I (/O MKP/I -/I 3/I )/O is/O a/O dual/O specificity/O phosphatase/O that/O inactivates/O extracellular/I signal/I -/I regulated/I kinase/I (/O ERK/I )/O MAP/I kinases/I ./O
Consistent/O with/O this/O ,/O we/O show/O that/O peptides/O representing/O docking/O sites/O within/O the/O target/O substrates/O Elk/I -/I 1/I and/O p90/I (/O rsk/I )/O inhibit/O ERK/I -/O dependent/O activation/O of/O MKP/I -/I 3/I ./O
HPLC/O phosphopeptide/O mapping/O ,/O amino/O acid/O sequencing/O ,/O and/O site/O -/O directed/O mutagenesis/O determined/O that/O NCLK/I phosphorylates/O Ser/O (/O 67/O )/O of/O I/I -/I 1/I ./O
When/O the/O entire/O diet/O consisted/O of/O SBF/O ,/O voluntary/O feed/O intake/O was/O reduced/O ,/O indicating/O that/O SBF/O should/O not/O be/O fed/O to/O ponies/O as/O the/O sole/O dietary/O ingredient/O ./O
Hepatitis/O C/O virus/O infection/O and/O lymphoproliferative/O diseases/O in/O France/O :/O a/O national/O study/O ./O
The/O immune/O system/O is/O closely/O integrated/O with/O the/O neuroendocrine/O system/O ,/O and/O infection/O -/O induced/O increases/O in/O cytokines/O such/O as/O IL/I -/I 1/I ,/O IL/I -/I 6/I and/O TNF/I have/O numerous/O effects/O on/O the/O central/O nervous/O system/O ./O
Interestingly/O ,/O a/O decreased/O transcription/O from/O the/O endogenous/O c/I -/I Myb/I promoter/I was/O observed/O in/O several/O HTLV/O -/O I/O transformed/O T/O -/O cell/O lines/O ./O
H19/I and/O Igf2/I monoallelic/O expression/O is/O regulated/O in/O two/O distinct/O ways/O by/O a/O shared/O cis/O acting/O regulatory/O region/O upstream/O of/O H19/I ./O
C/O ./O elegans/O KLP/I -/I 11/I //O OSM/I -/I 3/I //O KAP/I -/I 1/I :/O orthologs/O of/O the/O sea/I urchin/I kinesin/I -/I II/I ,/O and/O mouse/O KIF3A/I //O KIFB/I //O KAP3/I kinesin/I complexes/O ./O
Flavonoids/O from/O Brosimum/O acutifolium/O ./O
BACKGROUND/O :/O Hepatic/O encephalopathy/O is/O a/O neuropsychiatric/O syndrome/O associated/O with/O acute/O liver/O failure/O ,/O chronic/O parenchymal/O liver/O disease/O or/O portal/O systemic/O anastomosis/O ./O
These/O natural/O antisense/O S/I transcripts/I co/O -/O exist/O with/O several/O less/O abundant/O sense/O S/I transcripts/I ./O
Nor/O is/O such/O adjustment/O possible/O unless/O one/O posits/O a/O model/O that/O relates/O the/O missing/O observations/O to/O other/O observed/O information/O for/O each/O subject/O -/O models/O that/O are/O inherently/O untestable/O ./O
However/O ,/O the/O presence/O of/O effacement/O seems/O to/O be/O a/O more/O reliable/O and/O practical/O parameter/O that/O will/O be/O preferred/O in/O that/O prediction/O ./O
The/O data/O are/O compatible/O with/O the/O idea/O that/O YLL031c/I transfers/O the/O ethanolaminephosphate/O to/O the/O inner/O alpha1/O -/O 2/O -/O linked/O mannose/O ,/O i/O ./O e/O ./O the/O group/O that/O links/O the/O GPI/O lipid/O anchor/O to/O proteins/O ,/O whereas/O Mcd4p/I and/O Gpi7p/I transfer/O ethanolaminephosphate/O onto/O the/O alpha1/O -/O 4/O -/O and/O alpha1/O -/O 6/O -/O linked/O mannoses/O of/O the/O GPI/O anchor/O ,/O respectively/O ./O
The/O C/O terminus/O of/O TRBP/I binds/O to/O CBP/I //O p300/I and/O DRIP130/I ,/O a/O component/O of/O the/O DRIP/I //O TRAP/I //O ARC/I complex/O ,/O which/O suggests/O that/O TRBP/I may/O activate/O transcription/O by/O means/O of/O such/O interactions/O ./O
The/O patients/O who/O presented/O with/O mucocutaneous/O disease/O also/O had/O low/O CD4/I +/I T/O lymphocyte/O counts/O ,/O and/O most/O of/O them/O had/O AIDS/O defining/O illnesses/O ./O
Increased/O dietary/O energy/O decreased/O PAB/O and/O the/O use/O of/O added/O dietary/O CO/O rather/O than/O PF/O decreased/O PSHL/O in/O broiler/O breeders/O between/O 26/O and/O 47/O wk/O of/O age/O ./O
The/O gene/O amplification/O model/O of/O Coquelle/O et/O al/O ./O
Hierarchy/O of/O protein/I tyrosine/I kinases/I in/O interleukin/I -/I 2/I (/O IL/I -/I 2/I )/O signaling/O :/O activation/O of/O syk/I depends/O on/O Jak3/I ;/O however/O ,/O neither/O Syk/I nor/O Lck/I is/O required/O for/O IL/I -/I 2/I -/O mediated/O STAT/I activation/O ./O
Immobilized/O dimers/O of/O N/I -/I cadherin/I -/O Fc/I chimera/O mimic/O cadherin/O -/O mediated/O cell/O contact/O formation/O :/O contribution/O of/O both/O outside/O -/O in/O and/O inside/O -/O out/O signals/O ./O
Although/O the/O OC/I promoter/I is/O activated/O in/O a/O C/O terminus/O dependent/O manner/O ,/O the/O MDR/I ,/O LTR/O and/O BSP/I promoters/I are/O repressed/O by/O three/O distinct/O mechanisms/O ,/O either/O independent/O of/O or/O involving/O the/O AML/I C/I terminus/I ,/O or/O requiring/O only/O the/O conserved/O C/O -/O terminal/O pentapeptide/O VWRPY/O ./O
The/O monoclonal/O immunoglobulin/I products/O of/O plasma/O cell/O neoplasm/O can/O give/O rise/O to/O a/O variety/O of/O manifestations/O including/O hyperviscosity/O ,/O amyloidosis/O ,/O cryoglobulinemia/O ,/O neuropathy/O ,/O and/O renal/O failure/O ./O
Investigation/O of/O the/O structural/O basis/O of/O the/O interaction/O between/O human/I Igs/I and/O gp120/I shows/O that/O the/O viral/I gp120/I SAg/I can/O interact/O only/O with/O a/O subset/O of/O human/I V/I (/I H/I )/I 3/I +/I Igs/I ./O
Double/O -/O blind/O ,/O placebo/O -/O controlled/O trial/O ./O
Here/O ,/O it/O is/O shown/O that/O TAFII250/I ,/O the/O largest/O subunit/O of/O TFIID/I ,/O contains/O two/O tandem/O bromodomain/O modules/O that/O bind/O selectively/O to/O multiply/O acetylated/O histone/I H4/I peptides/I ./O
Endostatin/O treatment/O for/O 10/O minutes/O or/O 24/O hours/O induced/O tyrosine/O phosphorylation/O of/O Shb/I and/O formation/O of/O multiprotein/O complexes/O ./O
Therefore/O ,/O analogs/O of/O vitamin/O D3/O have/O been/O investigated/O in/O a/O number/O of/O trials/O showing/O improvement/O of/O psoriasis/O ./O
The/O transcript/O was/O initially/O identified/O as/O a/O partial/O cDNA/O sequence/O in/O the/O course/O of/O constructing/O a/O transcript/O map/O of/O the/O region/O between/O markers/O D11S1765/I and/O uteroglobin/I known/O to/O encompass/O the/O gene/O causing/O Best/O disease/O ./O
The/O real/O challenge/O for/O the/O future/O will/O be/O the/O management/O of/O patients/O who/O do/O not/O respond/O to/O first/O -/O line/O treatment/O ./O
Iodine/O deficiency/O disorders/O in/O Bangladesh/O ./O
The/O network/O evolution/O was/O interpreted/O by/O an/O approach/O based/O on/O the/O Flory/O model/O ./O
RESULTS/O :/O Soluble/O CD23/I levels/O were/O significantly/O higher/O in/O women/O with/O endometriosis/O before/O treatment/O than/O in/O ten/O normal/O controls/O ./O
CONCLUSION/O :/O Our/O findings/O suggest/O that/O endometriosis/O increases/O soluble/O CD23/I levels/O ,/O which/O can/O be/O suppressed/O with/O either/O danazol/O or/O leuprolide/O acetate/O injection/O ./O
To/O isolate/O this/O gene/O ,/O a/O P/O -/O 1/O artificial/O chromosome/O (/O PAC/O )/O library/O was/O screened/O with/O a/O full/I length/I UGT2B7/I probe/O and/O a/O clone/O of/O approximately/O 100/O kb/O in/O length/O was/O isolated/O ./O
Age/O >/=/O 50/O years/O (/O odds/O ratio/O [/O OR/O ],/O 14/O ./O 1/O ),/O BMI/O >/=/O 28/O kg/O //O m/O (/O 2/O )/O (/O OR/O ,/O 5/O ./O 7/O ),/O triglycerides/O >/=/O 1/O ./O 7/O mmol/O //O L/O (/O OR/O ,/O 5/O ),/O and/O alanine/I aminotransferase/I (/O ALT/I )/O >/=/O 2N/O (/O OR/O ,/O 4/O ./O 6/O )/O were/O independently/O associated/O with/O septal/O fibrosis/O ./O
Biologically/O significant/O amounts/O of/O platelet/I activating/I factor/I were/O eluted/O from/O the/O sorbent/O during/O the/O entire/O treatment/O time/O ./O
However/O ,/O the/O elderly/O group/O showed/O significantly/O longer/O mean/O residence/O times/O (/O MRTs/O )/O and/O lower/O plasma/O clearance/O of/O lidocaine/O during/O the/O period/O compared/O with/O the/O adult/O group/O (/O P/O /O or/O =/O 2/O cm/O should/O be/O adhered/O to/O ./O
Measurements/O were/O compared/O with/O two/O computerised/O treatment/O planning/O systems/O --/O Theraplan/O VO5B/O and/O ADAC/O Pinnacle3/O V4/O ./O 0b/O ./O
Activation/O was/O biphasic/O ;/O peaking/O at/O 5/O -/O 10/O min/O and/O 24/O h/O after/O treatment/O ./O
Whereas/O MARTA1/I is/O clearly/O detectable/O in/O crude/O lysates/O ,/O cytosolic/O and/O ribosomal/O salt/O -/O wash/O fractions/O ,/O and/O in/O nuclear/O extracts/O ,/O MARTA2/I is/O preferentially/O found/O in/O the/O ribosomal/O salt/O -/O wash/O preparation/O ./O
It/O contains/O 25/O exons/O coding/O for/O a/O 4/O ./O 7kb/O transcript/O including/O large/O 5/O '-/O and/O 3/O '-/O (/O 1218bp/O and/O 701bp/O ,/O respectively/O )/O untranslated/O regions/O (/O UTRs/O )./O
Five/O of/O the/O PDP1/I isoforms/I differ/O by/O the/O substitution/O or/O insertion/O of/O amino/O acids/O at/O or/O near/O the/O N/O -/O terminal/O of/O the/O protein/O ./O
The/O optimum/O technique/O for/O the/O pathological/O examination/O of/O sentinel/O lymph/O nodes/O (/O SLNs/O )/O is/O still/O under/O debate/O ./O
Partial/O correction/O of/O anemia/O with/O recombinant/I human/I erythropoietin/I likely/O reduces/O left/O ventricular/O mass/O and/O volume/O ./O
This/O study/O demonstrated/O that/O the/O PFA/O -/O 100/O analyzer/O can/O accurately/O assess/O vWF/I -/O dependent/O platelet/O function/O and/O detect/O other/O platelet/O defects/O under/O high/O shear/O stress/O in/O complex/O patient/O populations/O ./O
We/O recently/O reported/O the/O molecular/O cloning/O of/O a/O PL/I scramblase/I of/O human/O (/O HuPLSCR1/I )/O and/O mouse/O origin/O ,/O respectively/O ./O
To/O analyze/O the/O regulatory/O activity/O of/O Gtx/I ,/O we/O first/O identified/O the/O optimal/O Gtx/I -/I binding/I sequence/I using/O an/O in/O vitro/O DNA/O -/O binding/O assay/O ./O
Using/O an/O oligomer/O duplex/O 5/O '-/O A/O (/O GGGTTA/O )(/O 5/O )-/O 3/O '//O 5/O '-(/O TAACCC/O )(/O 5/O )/O T/O -/O 3/O '/O as/O a/O template/O -/O primer/O ,/O we/O show/O that/O both/O the/O Klenow/I fragment/I of/I Escherichia/I coli/I DNA/I polymerase/I I/I and/O HIV/I reverse/I transcriptase/I could/O expand/O telomere/O DNA/O sequences/O as/O well/O ,/O giving/O products/O greater/O than/O the/O size/O of/O the/O template/O DNA/O ./O
Cdk2/I and/O MAPK/I precipitates/O from/O untreated/O tumor/O lysates/O phosphorylated/O recombinant/I wild/I -/I type/I p27/I but/O not/O the/O T187A/O mutant/O in/O vitro/O ./O
The/O loss/O of/O avirulence/O activity/O because/O of/O mutations/O in/O the/O acidic/O transcriptional/O activation/O domain/O was/O restored/O by/O addition/O of/O the/O activation/O domain/O from/O the/O herpes/I simplex/I viral/I protein/I VP16/I ./O
Mutations/O in/O the/O RP2/I locus/I at/I Xp11/I ./I 3/I were/O found/O in/O a/O further/O 10/O -/O 20/O %/O of/O XLRP/O patients/O ,/O as/O predicted/O from/O linkage/O studies/O ./O
The/O limit/O between/O the/O cecum/O and/O the/O ascending/O colon/O was/O externally/O marked/O by/O the/O sulcus/O cecocolicus/O dorsalis/O and/O ventralis/O ./O
Subsequently/O ,/O HD/O inhibited/O healing/O because/O it/O significantly/O delayed/O epithelialization/O and/O caused/O protracted/O inflammation/O ./O
The/O effectiveness/O of/O the/O haemodialysate/O Solcoseryl/O for/O second/O -/O intention/O wound/O healing/O in/O horses/O and/O ponies/O ./O
Although/O there/O is/O little/O evidence/O that/O diet/O composition/O plays/O a/O clinically/O important/O role/O in/O the/O absorption/O or/O expenditure/O of/O energy/O ,/O it/O does/O appear/O to/O play/O a/O role/O in/O food/O intake/O ./O
These/O findings/O were/O reinforced/O by/O an/O analysis/O that/O was/O restricted/O to/O living/O donor/O transplants/O without/O acute/O rejection/O ./O
These/O results/O further/O support/O an/O important/O role/O for/O CBF2/I in/O mediating/O EBNA2/I transactivation/O ;/O they/O identify/O the/O hnRNP/I protein/I AUF1/I as/O a/O major/O component/O of/O CBF2/I and/O are/O also/O the/O first/O evidence/O of/O a/O cis/O -/O acting/O sequence/O other/O than/O a/O CBF1/I binding/I element/I that/O is/O able/O to/O confer/O responsiveness/O to/O EBNA2/I ./O
The/O genome/O of/O the/O human/O herpesvirus/O 8/O (/O HHV/O -/O 8/O )/O contains/O a/O cluster/O of/O open/O reading/O frames/O (/O ORFs/O )/O encoding/O proteins/O with/O homology/O to/O the/O cellular/O transcription/O factors/O of/O the/O interferon/I regulatory/I factor/I (/O IRF/I )/O family/O ./O
Despite/O these/O limitations/O the/O CHIME/O monitor/O provides/O an/O opportunity/O to/O record/O physiological/O data/O previously/O unavailable/O in/O the/O home/O ./O
DATA/O SYNTHESIS/O :/O Intracoronary/O ultrasound/O has/O been/O shown/O to/O improve/O upon/O demonstrated/O weaknesses/O of/O coronary/O angiography/O ./O
TB/O bone/O area/O (/O p/O /O 11/O ./O 1/O mIU/O //O ml/O or/O a/O stimulated/O day/O 10/O FSH/I level/O >/O 13/O ./O 5/O mIU/O //O ml/O conceived/O and/O carried/O a/O pregnancy/O ./O
Parathyroid/I hormone/I regulation/O of/O bone/I sialoprotein/I (/O BSP/I )/O gene/O transcription/O is/O mediated/O through/O a/O pituitary/I -/I specific/I transcription/I factor/I -/I 1/I (/O Pit/I -/I 1/I )/O motif/O in/O the/O rat/I BSP/I gene/I promoter/I ./O
Recent/O target/O BP/O goals/O promulgated/O by/O the/O Sixth/O Report/O from/O the/O Joint/O National/O Committee/O (/O JNC/O VI/O )/O are/O based/O on/O the/O premise/O that/O the/O intensity/O of/O treatment/O directly/O corresponds/O to/O the/O magnitude/O of/O pretreatment/O risk/O ./O
Linking/O continuous/O community/O -/O based/O morbidity/O recording/O of/O influenza/O -/O like/O illness/O (/O ILI/O )/O with/O virological/O sampling/O has/O consistently/O proved/O its/O value/O as/O one/O of/O the/O earliest/O indicators/O of/O circulating/O influenza/O activity/O ./O
The/O muskox/O is/O a/O new/O host/O record/O for/O T/O ./O gondii/O ./O
These/O include/O NPF/O repeats/O ,/O a/O leucine/O heptad/O repeat/O enriched/O in/O charged/O residues/O ,/O and/O a/O proline/O -/O rich/O SH3/I -/I like/I and/O //O or/O WW/O domain/O -/O binding/O site/O in/O the/O N/O -/O terminal/O domain/O ,/O which/O is/O followed/O by/O a/O membrane/O core/O containing/O four/O putative/O transmembrane/O spans/O and/O three/O amphiphilic/O segments/O that/O are/O the/O most/O highly/O conserved/O structural/O elements/O ./O
We/O show/O here/O that/O this/O difference/O is/O due/O to/O the/O presence/O of/O a/O Mot3/I binding/I site/I in/O OpA/I ./O
The/O article/O deals/O with/O the/O diagnosing/O and/O correction/O of/O reversible/O ischemia/O of/O the/O intestine/O ./O
Mucosal/O application/O of/O NCX/O -/O 4016/O ,/O however/O ,/O did/O not/O cause/O PD/O reduction/O and/O luminal/O H/O +/O loss/O ,/O but/O produced/O a/O marked/O hyperemia/O ,/O resulting/O in/O no/O damage/O in/O the/O stomach/O of/O both/O normal/O and/O STZ/O -/O diabetic/O rats/O ./O
Functional/O recognition/O of/O 5/O '/O splice/O site/O by/O U4/I //O U6/I ./O U5/I tri/O -/O snRNP/O defines/O a/O novel/O ATP/O -/O dependent/O step/O in/O early/O spliceosome/O assembly/O ./O
As/O control/O ,/O the/O cells/O were/O transfected/O with/O DNA/O mixtures/O containing/O vector/O mU6/O -/O C1/O or/O mU6/O -/O C2/O ./O
The/O amino/O acid/O sequence/O of/O matrilysin/I -/I 2/I also/O contains/O a/O threonine/O residue/O adjacent/O to/O the/O Zn/O -/O binding/O site/O that/O has/O been/O defined/O as/O a/O specific/O feature/O of/O matrilysin/I ./O
In/O this/O regard/O ,/O we/O have/O recently/O observed/O that/O a/O constitutively/O active/O G/I protein/I -/I coupled/I receptor/I (/O GPCR/I )/O encoded/O by/O the/O Kaposi/O '/O s/O sarcoma/O -/O associated/O herpes/O virus/O (/O KSHV/O )//O human/O herpes/O virus/O 8/O is/O oncogenic/O and/O stimulates/O angiogenesis/O by/O increasing/O the/O secretion/O of/O vascular/I endothelial/I growth/I factor/I (/O VEGF/I ),/O which/O is/O a/O key/O angiogenic/O stimulator/O and/O a/O critical/O mitogen/O for/O the/O development/O of/O Kaposi/O '/O s/O sarcoma/O ./O
No/O specific/O subgroup/O of/O clients/O benefited/O more/O from/O URD/O ,/O although/O a/O prospective/O study/O employing/O random/O assignment/O might/O be/O more/O successful/O in/O identifying/O such/O a/O group/O ./O
In/O the/O lattice/O ,/O 23/O %/O of/O the/O sites/O are/O occupied/O ,/O 95/O %/O of/O the/O atoms/O are/O in/O the/O lowest/O energy/O magnetic/O sublevel/O ,/O and/O 37/O %/O are/O in/O the/O lowest/O 3D/O vibrational/O state/O ./O
Coexisting/O vertical/O and/O horizontal/O one/O and/O a/O half/O syndromes/O ./O
As/O in/O the/O other/O three/O members/O whose/O gene/O expression/O is/O altered/O during/O tumorigenesis/O ,/O PI12/I expression/O was/O found/O to/O be/O down/O -/O regulated/O in/O tumor/O brain/O tissues/O and/O in/O two/O brain/O cancer/O cell/O lines/O :/O U/O -/O 87/O MG/O and/O H4/O ./O
Regarding/O "/O the/O relation/O between/O sexual/O orientation/O and/O penile/O size/O ,"/O by/O A/O ./O
This/O slope/O was/O further/O significantly/O decreased/O at/O 5/O min/O ischemia/O (-/O 26/O ./O 5/O +/-/O 8/O ./O 8/O microm/O //O mmHg/O )/O but/O returned/O toward/O control/O values/O in/O short/O -/O term/O hibernating/O myocardium/O at/O 90/O min/O ischemia/O (-/O 17/O ./O 2/O +/-/O 6/O ./O 6/O microm/O //O mmHg/O )./O
Whereas/O both/O MAP/O and/O MSNA/O increase/O during/O SHG/O ,/O the/O transition/O from/O SHG/O to/O PHI/O is/O characterized/O by/O a/O transient/O reduction/O in/O MAP/O but/O sustained/O elevation/O in/O MSNA/O ,/O facilitating/O separation/O of/O these/O factors/O in/O vivo/O ./O
Analysis/O of/O Standard/O Reference/O Material/O 1846/O ,/O Infant/O Formula/O ,/O gave/O a/O mean/O value/O of/O 0/O ./O 95/O +/-/O 0/O ./O 088/O mg/O vitamin/O K/O //O kg/O (/O K/O or/O K1/O ?)/O (/O n/O =/O 31/O )/O with/O a/O coefficient/O of/O variation/O of/O 9/O ./O 26/O ./O
We/O have/O recently/O discovered/O that/O CCAAAT/I //I enhancer/I -/I binding/I protein/I -/I beta/I (/O C/I //I EBP/I -/I beta/I )/O induces/O gene/O transcription/O through/O a/O novel/O IFN/I response/I element/I called/O the/O gamma/I -/I IFN/I -/I activated/I transcriptional/I element/I
Northern/O blot/O analysis/O demonstrated/O that/O the/O STORP/I gene/I has/O a/O ubiquitous/O pattern/O of/O expression/O similar/O to/O that/O of/O the/O PML/I gene/I ./O
In/O the/O TLE/O patients/O the/O NAA/O :/O Cr/O ratios/O were/O reduced/O in/O the/O seizure/O focus/O ,/O while/O in/O the/O FLE/O patients/O they/O were/O not/O always/O reduced/O in/O the/O seizure/O focus/O ./O
The/O Spo0F/I residues/I making/O up/O the/O hydrophobic/O patch/O are/O very/O similar/O in/O all/O response/O regulators/O suggesting/O that/O the/O binding/O is/O initiated/O through/O the/O same/O residues/O in/O all/O interacting/O response/O regulator/O -/O kinase/O pairs/O ./O
The/O psychologic/O factors/O associated/O wth/O serious/O illness/O ,/O terminal/O prognoses/O ,/O and/O dying/O complicate/O the/O scenario/O even/O more/O as/O compared/O with/O that/O of/O nonmalignant/O pain/O ./O
However/O ,/O if/O the/O spatial/O resolution/O is/O not/O critical/O and/O interest/O is/O to/O compare/O a/O pathologic/O area/O with/O a/O contralateral/O VOI/O ,/O then/O the/O acquisition/O of/O two/O single/O -/O voxel/O spectra/O may/O be/O preferred/O ./O
Quantitative/O evaluation/O of/O magneto/O -/O optical/O parameters/O is/O necessary/O in/O order/O to/O apply/O scanning/O near/O -/O field/O optical/O microscope/O (/O SNOM/O )/O technology/O to/O the/O study/O of/O magnetism/O on/O the/O mesoscopic/O scale/O ./O
We/O found/O that/O the/O amplitude/O of/O the/O cortical/O evoked/O potentials/O (/O amplitude/O of/O the/O N2/O //O P2/O peak/O )/O increased/O from/O 5/O ./O 1/O +/-/O 0/O ./O 7/O microV/O at/O 5/O mA/O to/O 16/O ./O 3/O +/-/O 1/O ./O 1/O microV/O at/O 20/O mA/O ./O
While/O mutations/O in/O K/I -/I Rev/I that/O inactivate/O any/O one/O of/O these/O properties/O also/O blocked/O K/I -/I Rev/I -/O dependent/O nuclear/O RNA/O export/O ,/O several/O K/I -/I Rev/I mutants/I were/O comparable/O to/O wild/O type/O when/O assayed/O for/O any/O of/O these/O individual/O activities/O yet/O nevertheless/O defective/O for/O RNA/O export/O ./O
LMP/I -/I 1/I is/O targeted/O to/O the/O plasma/O membrane/O ,/O where/O it/O binds/O TRAF/I ,/O TRADD/I ,/O and/O JAK/I molecules/I to/O activate/O NF/I -/I kappaB/I -,/O AP/I -/I 1/I -,/O and/O STAT/I -/O dependent/O pathways/O as/O does/O CD40/I ./O
Identification/O of/O an/O enhancer/O and/O an/O alternative/O promoter/O in/O the/O first/O intron/O of/O the/O alpha/I -/I fetoprotein/I gene/I ./O
Studying/O intracellular/O signaling/O pathways/O ,/O which/O may/O be/O involved/O in/O malignant/O transformation/O of/O Ret/I -/I 9bp/I expressing/O NIH3T3/O cells/O ,/O we/O could/O demonstrate/O Ret/I -/I 9bp/I dependent/O phosphorylation/O of/O insulin/I receptor/I substrate/I -/I 2/I (/O IRS/I -/I 2/I )/O with/O consecutive/O activation/O of/O phosphatidylinositol/I 3/I -/I kinase/I (/O PI/I 3/I -/I kinase/I )/O and/O protein/I kinase/I B/I (/O PKB/I //O AKT/I )./O
METHODS/O :/O In/O the/O current/O study/O the/O authors/O reported/O on/O PPB/O cases/O from/O a/O national/O retrospective/O search/O performed/O in/O 18/O Italian/O Associations/O for/O Pediatric/O Hematology/O and/O Oncology/O centers/O ./O
Phylogenetic/O analysis/O showed/O that/O the/O ToLCV/O isolates/O from/O Bangalore/O constitute/O a/O group/O of/O viruses/O separated/O from/O those/O of/O Northern/O India/O ./O
Mutating/O the/O Fcp1p/I -/O binding/O motif/O KEFGK/O in/O the/O RAP74/I (/O Tfg1p/I )/O subunit/O of/O TFIIF/I to/O EEFGE/O led/O to/O both/O synthetic/O phenotypes/O in/O certain/O fcp1/I tfg1/I double/O mutants/O and/O a/O reduced/O ability/O of/O Fcp1p/I to/O activate/O transcription/O when/O it/O is/O artificially/O tethered/O to/O a/O promoter/O ./O
These/O results/O suggest/O that/O Cdc42p/I is/O in/O fact/O required/O for/O pheromone/O response/O and/O that/O interaction/O with/O the/O PAK/I Ste20p/I is/O critical/O for/O that/O role/O ./O
Deletion/O of/O an/O intergenic/O DNA/O -/O binding/O site/O for/O this/O complex/O from/O a/O human/I beta/I -/I globin/I locus/I construct/I results/O in/O delayed/O human/I gamma/I -/I to/I beta/I -/I globin/I switching/O in/O transgenic/O mice/O ,/O suggesting/O that/O the/O PYR/I complex/I acts/O to/O facilitate/O the/O switch/O ./O
The/O product/O of/O rat/I gene/I 33/I was/O identified/O as/O an/O ErbB/I -/I 2/I -/I interacting/I protein/I in/O a/O two/O -/O hybrid/O screen/O employing/O the/O ErbB/I -/I 2/I juxtamembrane/I and/I kinase/I domains/I as/O bait/O ./O
Studies/O suggest/O that/O the/O DGOR/O without/O acid/O reflux/O may/O result/O in/O symptoms/O but/O unless/O acid/O reflux/O is/O present/O simultaneously/O ,/O it/O does/O not/O cause/O oesophagitis/O ./O
Symptoms/O ,/O however/O ,/O appear/O to/O correlate/O poorly/O with/O oesophagitis/O ;/O hence/O ,/O severe/O symptoms/O do/O not/O indicate/O there/O is/O greater/O oesophageal/O damage/O ./O
OBJECTIVE/O :/O To/O evaluate/O the/O relationship/O between/O blood/O flow/O in/O the/O tumor/O assessed/O by/O color/O Doppler/O ultrasound/O ,/O microvessel/O density/O ,/O and/O vascular/I endothelial/I growth/I factor/I levels/O in/O endometrial/O carcinoma/O ./O
These/O results/O demonstrate/O Ras/I -/O and/O Raf/I -/O independent/O ERK/I MAPK/O activation/O maintains/O cell/O viability/O following/O heat/O shock/O ./O
Three/O cDNAs/O encoding/O basic/I leucine/I zipper/I (/I bZIP/I )-/I type/I ABRE/I -/I binding/I proteins/I were/O isolated/O by/O using/O the/O yeast/O one/O -/O hybrid/O system/O and/O were/O designated/O AREB1/I ,/O AREB2/I ,/O and/O AREB3/I (/O ABA/I -/I responsive/I element/I binding/I protein/I )./O
Recombinant/O AROM/I -/O p64/I displayed/O high/O binding/O to/O single/O -/O stranded/O DNA/O and/O poly/O (/O A/O )/O homopolymers/O suggesting/O that/O this/O protein/O could/O play/O a/O role/O in/O mRNA/O maturation/O //O metabolism/O ./O
The/O protein/I -/I tyrosine/I kinase/I fer/I associates/O with/O signaling/O complexes/O containing/O insulin/I receptor/I substrate/I -/I 1/I and/O phosphatidylinositol/I 3/I -/I kinase/I ./O
The/O variable/O phenotype/O of/O the/O allotetraploids/O could/O not/O be/O explained/O by/O cytological/O abnormalities/O ./O
In/O the/O PMR/O target/O area/O but/O not/O in/O the/O nontreated/O area/O an/O improvement/O in/O regional/O myocardial/O flow/O reserve/O occurs/O in/O wall/O segments/O with/O initially/O severely/O or/O moderately/O reduced/O stress/O perfusion/O ./O
Analysis/O of/O intron/O //O exon/O boundaries/O of/O the/O genomic/O BAC/O clones/O demonstrate/O that/O junctin/I ,/O junctate/I ,/O and/O aspartyl/I beta/I -/I hydroxylase/I result/O from/O alternative/O splicing/O of/O the/O same/O gene/O ./O
It/O is/O now/O estimated/O that/O inactivation/O mutants/O of/O PTEN/I exist/O in/O 60/O %/O of/O all/O forms/O of/O solid/O tumors/O ./O
We/O have/O demonstrated/O that/O the/O activity/O of/O ILK/I is/O constitutively/O elevated/O in/O PTEN/I mutant/I cells/O ./O
The/O growth/I factor/I receptor/I -/I bound/I protein/I 2/I (/O Grb2/I )/O adaptor/O when/O complexed/O with/O Sos/I (/O Son/I of/I sevenless/I ),/O the/O exchange/O factor/O of/O Ras/I ,/O conveys/O the/O signal/O induced/O by/O tyrosine/I kinase/I -/I activated/I receptor/I to/O Ras/I by/O recruiting/O Sos/I to/O the/O membrane/O ,/O allowing/O activation/O of/O Ras/I ./O
Mutations/O in/O genes/O encoding/O PR65/I //I A/I subunits/I have/O been/O identified/O in/O several/O different/O human/O cancers/O and/O the/O PP2A/I inhibitor/O ,/O termed/O fostriecin/O ,/O is/O being/O tested/O as/O an/O anticancer/O drug/O ./O
For/O this/O purpose/O ,/O a/O segment/O of/O dxr/I was/O amplified/O from/O Synechococcus/O leopoliensis/O SAUG/O 1402/O -/O 1/O DNA/O via/O PCR/O using/O oligonucleotides/O for/O conserved/O regions/O ./O
Perceptual/O learning/O for/O a/O pattern/O discrimination/O task/O ./O
The/O detector/O has/O the/O advantage/O of/O finding/O both/O ST/O segment/O deviations/O and/O entire/O ST/O -/O T/O complex/O changes/O thereby/O providing/O a/O wider/O characterization/O of/O the/O potential/O ischemic/O events/O ./O
While/O this/O Saccharomyces/O cerevisiae/O SIN4/I gene/I product/I is/O a/O component/O of/O a/O mediator/O complex/O associated/O with/O RNA/I polymerase/I II/I ,/O various/O studies/O suggest/O the/O involvement/O of/O Sin4/I in/O the/O alteration/O of/O higher/O -/O order/O chromatin/O structure/O ./O
Primary/O adrenal/O hypersensitivity/O to/O ACTH/I drive/O in/O obesity/O has/O also/O been/O suggested/O ./O
In/O addition/O ,/O a/O noncanonical/O C/I //I EBP/I -/I binding/I site/I within/O the/O Gadd45gamma/I promoter/I where/O C/I //I EBPbeta/I and/O C/I //I EBPdelta/I could/O bind/O ,/O was/O identified/O by/O electrophoretic/O mobility/O shift/O assay/O (/O EMSA/O )/O and/O reporter/O gene/O analysis/O ./O
Src/I activation/O induced/O by/O FGF1/I was/O blocked/O by/O the/O SH2/I domain/I of/O Src/I and/O PP2/I ,/O a/O specific/O inhibitor/O of/O Src/I ./O
The/O use/O of/O the/O PLCgamma/I inhibitory/I peptide/I ,/O neomycin/O and/O the/O calcium/O chelator/O BAPTA/O -/O AM/O on/O oocytes/O expressing/O FGFR1/I or/O the/O stimulation/O by/O PDGF/I -/I BB/I of/O oocytes/O expressing/O PDGFR/I -/O FGFR1/I mutated/O on/O the/O PLCgamma/I binding/I site/I ,/O prevented/O GVBD/O and/O ERK2/I phosphorylation/O ./O
Multiple/O transcription/O start/O sites/O were/O revealed/O by/O primer/O extension/O analysis/O of/O the/O mouse/O gene/O ,/O and/O transfection/O constructs/O containing/O the/O prospective/O promoter/O generated/O transcriptional/O activity/O comparable/O to/O that/O of/O the/O SV40/I promoter/I ./O
From/O two/O inhibitor/O scaffolds/O ,/O we/O have/O identified/O potent/O and/O selective/O inhibitors/O for/O sensitized/O kinases/O from/O five/O distinct/O subfamilies/O ./O
To/O determine/O whether/O interaction/O of/O arsenite/O with/O the/O hormone/O -/O binding/O domain/O results/O in/O receptor/O activation/O ,/O COS/O -/O 1/O cells/O were/O transiently/O cotransfected/O with/O the/O chimeric/I receptors/I GAL/I -/I ER/I ,/O which/O contains/O the/O hormone/O -/O binding/O domain/O of/O ERalpha/I and/O the/O DNA/O -/O binding/O domain/O of/O the/O transcription/O factor/O GAL4/I ,/O and/O a/O GAL4/I -/O responsive/O CAT/I reporter/I gene/I ./O
By/O progressive/O 5/O '-/O deletion/O studies/O ,/O we/O have/O identified/O a/O 248/O -/O bp/O DNA/O fragment/O (-/O 1018/O to/O -/O 771/O ,/O relative/O to/O the/O translation/O start/O site/O )/O at/O the/O 5/O '-/O flanking/O region/O of/O the/O human/I GnRHR/I gene/I that/O is/O responsible/O for/O the/O GnRHa/O -/O mediated/O down/O -/O regulation/O of/O human/I GnRHR/I promoter/I activity/O ./O
The/O mean/O day/O of/O diagnosis/O of/O periventricular/O echodensities/O was/O 3/O +/-/O 2/O days/O (/O range/O 1/O -/O 11/O days/O ),/O and/O of/O cystic/O PVL/O 21/O +/-/O 8/O days/O (/O range/O 2/O -/O 47/O days/O )./O
The/O LAMMER/I protein/O kinase/O encoded/O by/O the/O Doa/I locus/I of/O Drosophila/O is/O required/O in/O both/O somatic/O and/O germline/O cells/O and/O is/O expressed/O as/O both/O nuclear/O and/O cytoplasmic/O isoforms/O throughout/O development/O ./O
We/O have/O mutated/O to/O cysteine/O ,/O one/O at/O a/O time/O ,/O 21/O consecutive/O residues/O in/O the/O fourth/O TMS/O (/O TM4/O )./O
(/O 1995/O )/O J/O ./O
HYPOTHESIS/O :/O The/O aim/O of/O this/O study/O was/O to/O investigate/O the/O oxidative/O susceptibility/O of/O apolipoprotein/I B/I -/I containing/I lipoproteins/I and/O antioxidant/O status/O in/O patients/O with/O acute/O coronary/O syndromes/O and/O chronic/O stable/O angina/O pectoris/O ./O
In/O group/O B/O 37/O MBq/O in/O 150/O microL/O of/O 99mTc/O -/O HSA/O nanocolloid/O was/O additionally/O injected/O intradermally/O 18/O h/O before/O surgery/O (/O 3/O -/O 6/O aliquots/O injected/O perilesionally/O )./O
Post/O -/O operative/O functional/O outcome/O is/O related/O to/O pre/O -/O operative/O functional/O status/O ./O
We/O cloned/O a/O DNA/O fragment/O encoding/O the/O N/O -/O terminal/O part/O of/O a/O protein/O with/O significant/O similarity/O to/O members/O of/O the/O LysR/I family/I of/I transcriptional/I regulators/I (/O LTTRs/I )./O
AGO1/I is/O similar/O to/O QDE/I -/I 2/I required/O for/O quelling/O and/O RDE/I -/I 1/I required/O for/O RNAi/O ./O
Intracellular/O localization/O studies/O using/O the/O mDAP/I -/I 3/I //O EGFP/I fusion/O protein/O ,/O cell/O fractionation/O and/O protease/O protection/O experiments/O localized/O mDAP/I -/I 3/I to/O the/O mitochondrial/O matrix/O ./O
We/O could/O demonstrate/O the/O involvement/O of/O cAMP/I -/I dependent/I protein/I kinase/I (/O PKA/I )/O in/O the/O phosphorylation/O of/O CDC25Mm/I in/O fibroblasts/O overexpressing/O this/O RasGEF/I as/O well/O as/O in/O mouse/O brain/O synaptosomal/O membranes/O ./O
Reporter/O gene/O expression/O analyses/O indicate/O that/O both/O WASP/I promoters/I show/O high/O levels/O of/O expression/O in/O different/O hematopoietic/O cell/O lines/O ./O
We/O find/O that/O 3T1/O -/O 3T2/O mixing/O has/O a/O pronounced/O effect/O on/O the/O line/O shape/O and/O radiative/O decay/O rate/O of/O emission/O from/O the/O 3T2/O state/O and/O that/O the/O extent/O of/O mixing/O depends/O critically/O on/O the/O magnitude/O of/O nontetrahedral/O distortions/O ./O
A/O total/O of/O 576/O 1/O -/O day/O -/O old/O Ross/O broiler/O chicks/O were/O housed/O in/O six/O treatment/O groups/O [/O six/O replicates/O of/O 16/O each/O ;/O control/O ,/O CLI/O (/O 15/O g/O kg/O (-/O 1/O )/O diet/O ),/O 50/O parts/O per/O billion/O (/O ppb/O )/O AF/I ,/O 50/O ppb/O AF/I plus/O CLI/O ,/O 100/O ppb/O AF/I ,/O 100/O ppb/O AF/I plus/O CLI/O ]/O for/O 42/O days/O ./O
The/O cost/O per/O test/O is/O less/O than/O those/O for/O CC/O ,/O kEIA/O and/O PACE2/O ./O
Altogether/O these/O results/O suggest/O that/O ,/O in/O KG1a/O cells/O ,/O TNFalpha/I can/O stimulate/O in/O parallel/O PC/I -/I PLC/I and/O PLD/I ,/O whose/O lipid/O products/O activate/O in/O turn/O mitogen/I -/I activated/I protein/I kinase/I (/O MAP/I kinase/I )/O and/O NF/I -/I kappaB/I signalling/O respectively/O ./O
Concurrently/O ,/O we/O monitored/O weather/O conditions/O and/O used/O time/O -/O activity/O budget/O data/O of/O free/O -/O living/O birds/O and/O laboratory/O data/O on/O resting/O metabolic/O rate/O to/O construct/O time/O -/O activity/O laboratory/O (/O TAL/O )/O estimates/O of/O daily/O energy/O expenditure/O (/O DEE/O )/O and/O to/O partition/O the/O verdins/O '/O energy/O budget/O into/O thermoregulatory/O ,/O activity/O and/O basal/O components/O ./O
L/O //O H/O >/O 0/O ./O 61/O (/O chi/O (/O 2/O )=/O 10/O ./O 8/O ;/O P/O :/O 2/O ./O 0/O x/O 10/O (/O 9/O )//O l/O and/O platelet/O nadir/O count/O was/O >/O 75/O x/O 10/O (/O 9/O )//O l/O ./O
Methyl/O formate/O was/O used/O as/O the/O solvent/O of/O biodegradable/O oligoesters/O for/O the/O fabrication/O of/O microspheres/O with/O encapsulated/O bovine/I serum/I albumin/I (/O BSA/I )./O
The/O small/I monomeric/I GTP/I -/I binding/I proteins/I of/O the/O RAB/I subfamily/I are/O key/O regulatory/O elements/O of/O the/O machinery/O that/O controls/O membrane/O traffic/O in/O eukaryotic/O cells/O ./O
Furthermore/O ,/O loss/O of/O methylation/O also/O greatly/O reduced/O the/O association/O of/O another/O yeast/O B/O -/O type/O subunit/O ,/O Rts1p/I ./O
Thus/O ,/O methylation/O of/O Pph21p/I is/O important/O for/O formation/O of/O PP2A/I trimeric/I and/I dimeric/I complexes/I ,/O and/O consequently/O ,/O for/O PP2A/I function/O ./O
The/O purpose/O of/O this/O study/O was/O to/O analyze/O the/O temporal/O characteristics/O and/O the/O spatial/O mapping/O of/O the/O independent/O components/O identified/O by/O ICA/O when/O the/O subject/O performs/O a/O finger/O -/O tapping/O task/O ./O
The/O authors/O present/O the/O only/O two/O studies/O that/O have/O proved/O successful/O in/O treating/O animal/O models/O of/O osteoarthritis/O using/O gene/O therapy/O ,/O and/O propose/O an/O overview/O of/O several/O strategies/O for/O the/O development/O of/O gene/O therapy/O in/O osteoarthritis/O treatment/O in/O the/O future/O ./O
Together/O ,/O these/O results/O indicate/O that/O IL/I -/I 1/I beta/I induces/O VEGF/I gene/I expression/O at/O both/O transcriptional/O and/O post/O -/O transcriptional/O levels/O ,/O and/O IL/I -/I 1/I beta/I evokes/O p38/I MAPK/O and/O JNK/I signalings/O ,/O which/O in/O turn/O stimulate/O the/O transcription/O of/O the/O VEGF/I gene/I through/O Sp1/I -/I binding/I sites/I ./O
Binding/O of/O NusA/I to/O RNA/O in/O the/O presence/O of/O alpha/O or/O N/O involves/O an/O amino/I -/I terminal/I S1/I homology/I region/I that/O is/O otherwise/O inactive/O in/O full/I -/I length/I NusA/I ./O
The/O subjects/O were/O diagnosed/O on/O the/O basis/O of/O DSM/O -/O IV/O pathological/O gambling/O criteria/O and/O completed/O the/O Turkish/O Version/O of/O South/O Oaks/O Gambling/O Screen/O (/O SOGS/O )./O
Lys/O (/O 193/O )/O and/O Arg/O (/O 194/O ),/O located/O at/O the/O COOH/O -/O terminal/O end/O of/O HD/I ,/O are/O essential/O for/O dimerization/O ./O
Elevation/O of/O intracellular/O Ca/O (/O 2/O +)/O levels/O are/O also/O involved/O because/O treatment/O with/O receptor/O -/O associated/O protein/O ,/O nifedipine/O ,/O MK801/O ,/O removal/O of/O Ca/O (/O 2/O +)/O from/O the/O medium/O and/O dantrolene/O all/O served/O to/O inhibit/O calcium/O elevation/O and/O attenuate/O the/O activation/O of/O CREB/I ./O
The/O present/O study/O shows/O that/O phosphatidylinositol/I 3/I -/I kinase/I -/O dependent/O p38/I kinase/I activation/O regulates/O Akt/I phosphorylation/O and/O activity/O in/O human/O neutrophils/O ./O
When/O BFDS/O was/O taken/O as/O the/O reference/O ,/O W/O //O A/O Z/O scores/O showed/O consistent/O positive/O increments/O ,/O from/O birth/O in/O girls/O and/O 1/O mo/O in/O boys/O ./O
These/O probable/O border/O sequences/O are/O closely/O related/O to/O those/O of/O other/O known/O T/O -/O regions/O and/O define/O a/O second/O T/O -/O region/O of/O pTiChry5/O ,/O called/O T/O -/O right/O (/O TR/O ),/O that/O confers/O production/O of/O the/O Amadoriopines/O ./O
Using/O purified/O recombinant/I HMG/I I/I ,/O we/O have/O identified/O several/O high/O -/O affinity/O binding/O sites/O which/O overlap/O important/O transcription/O factor/O binding/O sites/O ./O
High/I -/I mobility/I -/I group/I protein/I I/I can/O modulate/O binding/O of/O transcription/O factors/O to/O the/O U5/I region/I of/O the/O human/I immunodeficiency/I virus/I type/I 1/I proviral/I promoter/I ./O
Another/O cis/O -/O acting/O element/O ,/O exonic/O splicing/O suppressor/O 1/O (/O ESS1/O ),/O represses/O use/O of/O the/O nt/O 3225/O 3/O '/O splice/O site/O ./O
Leptinaemia/O does/O not/O correlate/O with/O the/O actual/O or/O mean/O blood/O pressure/O reading/O nor/O with/O stage/O of/O hypertension/O according/O to/O the/O WHO/O classification/O ./O
5/O '-/O RACE/O analysis/O suggested/O a/O single/O transcription/O initiation/O site/O 187/O bp/O upstream/O from/O the/O translational/O start/O site/O ./O
Thus/O ,/O diamide/O treatment/O of/O nuclear/O extracts/O strongly/O reduces/O the/O binding/O of/O NFI/I proteins/I ,/O and/O the/O addition/O of/O higher/O concentrations/O of/O dithiothreitol/O to/O nuclear/O extracts/O from/O TG/I -/O treated/O cells/O restores/O NFI/I -/I DNA/I binding/O to/O levels/O in/O extracts/O from/O untreated/O cells/O ./O
LMP2A/I enhances/O Lyn/I and/O Syk/I ubiquitination/O in/O vivo/O in/O a/O fashion/O that/O depends/O on/O the/O activity/O of/O Nedd4/I family/O members/O and/O correlates/O with/O destabilization/O of/O the/O Lyn/I tyrosine/I kinase/I ./O
Further/O ,/O Tax/I -/O mediated/O apoptosis/O was/O effectively/O prevented/O by/O ectopic/O expression/O of/O the/O p300/I coactivator/I ./O
Our/O results/O ,/O however/O ,/O were/O obtained/O for/O Z/O itself/O and/O not/O for/O [/O Z/O ]./O
Fisher/O '/O s/O exact/O test/O or/O Pearson/O '/O s/O chi2/O test/O were/O used/O for/O statistical/O analysis/O ./O
RESULTS/O :/O In/O the/O pregnant/O group/O ,/O serum/O PP14/I concentrations/O were/O markedly/O increased/O after/O ET/O ,/O and/O a/O significant/O difference/O between/O the/O pregnant/O group/O and/O the/O nonpregnant/O group/O was/O observed/O 8/O days/O following/O ET/O (/O p/O /O Ser/O )/O fused/O to/O glutathione/I -/I S/I -/I transferase/I (/O GST/I )./O
Thus/O ,/O Pet111p/I could/O play/O dual/O roles/O in/O both/O membrane/O localization/O and/O regulation/O of/O Cox2p/I synthesis/O within/O mitochondria/O ./O
Furthermore/O ,/O transfection/O of/O cells/O with/O the/O spacer/O -/O RING/O domain/O alone/O suppressed/O the/O antiapoptotic/O function/O of/O the/O N/O -/O terminal/O BIR/I domain/O of/O c/I -/I IAP1/I and/O induced/O apoptosis/O ./O
The/O determination/O of/O the/O double/O bounds/O in/O blood/O serum/O lipids/O by/O titration/O with/O ozone/O :/O the/O pathophysiology/O and/O diagnostic/O significance/O ]/O In/O this/O article/O the/O method/O of/O definition/O of/O double/O binders/O in/O lipids/O of/O blood/O serum/O in/O patients/O with/O different/O diseases/O basically/O atherosclerosis/O and/O ischemic/O heart/O disease/O ,/O with/O use/O titration/O by/O ozone/O is/O given/O ./O
Ang/I II/I -/O induced/O fibronectin/I mRNA/O was/O not/O affected/O by/O PKC/I inhibitors/O or/O PKC/I depletion/O ,/O whereas/O specific/O inhibition/O of/O EGF/I -/I R/I function/O by/O a/O dominant/I negative/I EGF/I -/I R/I mutant/I and/O tyrphostin/O AG1478/O abolished/O induction/O of/O fibronectin/I mRNA/I ./O
Acoust/O ./O
Video/O images/O of/O the/O nostrils/O were/O captured/O and/O then/O analyzed/O for/O area/O ,/O perimeter/O ,/O centroid/O ,/O principal/O axis/O ,/O moments/O about/O the/O major/O and/O minor/O axes/O (/O I11/O ,/O I22/O ),/O anisometry/O ,/O bulkiness/O ,/O lateral/O offset/O ,/O internostril/O angle/O ,/O and/O rotational/O angle/O ./O
MS/O characteristics/O of/O coumarins/O ,/O psoralens/O and/O polymethoxylated/O flavones/O with/O different/O substitution/O patterns/O were/O determined/O on/O the/O basis/O of/O the/O response/O obtained/O with/O the/O APcI/O interface/O ./O
Young/O fish/O (/O Oreochromis/O mossambicus/O )/O were/O exposed/O to/O microgravity/O (/O micro/O g/O )/O for/O 9/O to/O 10/O days/O during/O space/O missions/O STS/O -/O 55/O and/O STS/O -/O 84/O ,/O or/O to/O hypergravity/O (/O hg/O )/O for/O 9/O days/O ./O
S6K2/I is/O highly/O homologous/O to/O S6K1/I in/O the/O core/O kinase/O and/O linker/O regulatory/O domains/O but/O differs/O from/O S6K1/I in/O the/O N/O -/O and/O C/O -/O terminal/O regions/O and/O is/O differently/O localized/O primarily/O to/O the/O nucleus/O because/O of/O a/O C/O -/O terminal/O nuclear/O localization/O signal/O unique/O to/O S6K2/I ./O
Pretreatment/O of/O cells/O with/O the/O mitogen/I -/I activated/I protein/I -/I extracellular/I signal/I -/I regulated/I kinase/I kinase/I (/O MEK/I )/O inhibitor/O U0126/O inhibited/O S6K2/I activation/O to/O a/O greater/O extent/O than/O S6K1/I ./O
T/O cells/O express/O two/O isoforms/O of/O S6k1/I :/O a/O 70/O kDa/O cytoplasmic/O kinase/O and/O an/O 85/O kDa/O isoform/O that/O has/O a/O classic/O nuclear/O localisation/O ./O
Ketanserin/O ,/O a/O hypotensive/O drug/O with/O 5/I -/I HT2/I receptor/I antagonism/O ,/O when/O administered/O by/O topical/O infusion/O of/O a/O 0/O ./O 25/O %/O w/O //O v/O solution/O by/O corneal/O and/O scleral/O applications/O ,/O was/O found/O to/O lower/O intraocular/O pressure/O with/O four/O times/O more/O activity/O than/O its/O metabolite/O ,/O ketanserinol/O ./O
A/O prospectively/O gated/O 2D/O axial/O sequence/O with/O velocity/O encoding/O in/O the/O craniocaudal/O direction/O in/O the/O cervical/O region/O was/O set/O at/O a/O velocity/O of/O +/-/O 10/O cm/O //O s/O ./O
It/O was/O subsequently/O shown/O that/O Tip60/I had/O histone/I acetyltransferase/I (/O HAT/I )/O activity/O ./O
Our/O data/O show/O that/O multiple/O MLSN1/I transcripts/I ,/O both/O constitutively/O expressed/O and/O inducible/O ,/O are/O present/O in/O cultured/O pigmented/O melanoma/O cells/O ,/O and/O suggest/O that/O MLSN1/I expression/O can/O be/O regulated/O at/O the/O level/O of/O both/O transcription/O and/O mRNA/O processing/O ./O
Copyright/O 2000/O Academic/O Press/O ./O
Plectin/I and/O desmoplakin/I have/O GSR/O -/O containing/O domains/O at/O their/O C/O -/O termini/O and/O we/O further/O demonstrate/O that/O the/O GSR/O -/O containing/O domain/O of/O plectin/I ,/O but/O not/O desmoplakin/I ,/O can/O bind/O to/O MTs/O in/O vivo/O ./O
Characterization/O of/O the/O microtubule/O binding/O domain/O of/O microtubule/I actin/I crosslinking/I factor/I (/O MACF/I ):/O identification/O of/O a/O novel/O group/O of/O microtubule/I associated/I proteins/I ./O
These/O results/O also/O suggest/O the/O involvement/O of/O additional/O elements/O in/O the/O UPR/O ./O
We/O show/O that/O in/O contrast/O to/O SRC1/I ,/O direct/O binding/O of/O CBP/I to/O the/O estrogen/I receptor/I is/O weak/O ,/O suggesting/O that/O SRC1/I functions/O primarily/O as/O an/O adaptor/O to/O recruit/O CBP/I and/O p300/I ./O
Remarkably/O ,/O a/O construct/O corresponding/O to/O residues/O 631/O to/O 970/O ,/O which/O contains/O only/O the/O LXXLL/O motifs/O and/O the/O AD1/O region/O of/O SRC1/I ,/O retained/O strong/O coactivator/O activity/O in/O our/O assays/O ./O
Since/O MEK/I acts/O as/O a/O cytoplasmic/O anchor/O for/O the/O ERKs/I ,/O the/O lack/O of/O a/O MEK/I interaction/O resulted/O in/O the/O aberrant/O nuclear/O localization/O of/O ERK2/I -/O Delta19/I -/I 25/I mutants/O in/O serum/O -/O starved/O cells/O ./O
Pmt2/I is/O a/O member/O of/O a/O six/O -/O protein/O family/O in/O yeast/O that/O catalyzes/O the/O first/O step/O in/O O/O mannosylation/O of/O target/O proteins/O ./O
Fecal/O samples/O were/O collected/O at/O the/O beginning/O and/O end/O of/O each/O trial/O period/O and/O were/O analyzed/O for/O gastrointestinal/O nematode/O eggs/O and/O Giardia/O cyst/O ./O
The/O aim/O of/O this/O study/O was/O to/O determine/O the/O risk/O factors/O for/O background/O diabetic/O retinopathy/O (/O BDR/O )/O and/O PDR/O by/O following/O 394/O Japanese/O patients/O with/O early/O -/O onset/O type/O 2/O diabetes/O diagnosed/O before/O 30/O years/O of/O age/O (/O mean/O age/O 27/O ,/O mean/O blood/O pressure/O at/O entry/O 116/O //O 73/O mm/O Hg/O )./O
Of/O the/O 21/O quadrants/O positive/O in/O the/O controls/O ,/O 17/O were/O correlated/O with/O previously/O detected/O jaw/O pathoses/O ./O
Four/O cases/O of/O synovial/O chondromatosis/O are/O presented/O ./O
Previous/O studies/O have/O shown/O that/O the/O pro/O -/O inflammatory/O cytokines/O tumor/I necrosis/I factor/I alpha/I and/O interferon/I gamma/I reduce/O the/O expression/O of/O the/O cystic/I fibrosis/I transmembrane/I conductance/I regulator/I (/O CFTR/I )/O gene/O (/O CFTR/I )/O in/O HT/O -/O 29/O and/O T84/O cells/O by/O acting/O post/O -/O transcriptionally/O ./O
Regulation/O of/O RhoA/I is/O required/O to/O maintain/O adhesion/O in/O stationary/O cells/O ,/O but/O is/O also/O critical/O for/O cell/O spreading/O and/O migration/O [/O 3/O ]./O
Here/O we/O show/O in/O mouse/O fibroblasts/O stably/O transformed/O by/O v/I -/I Src/I that/O mRNA/O and/O protein/O levels/O of/O p21/I (/O WAF1/I //O CIP1/I ),/O cyclin/I D1/I ,/O and/O cyclin/I E/I are/O elevated/O ./O
ORFA/O and/O ccdA/I were/O constitutively/O cotranscribed/O as/O determined/O by/O primer/O extension/O analysis/O ./O
Mouse/I Impact/I is/O a/O paternally/O expressed/O gene/O encoding/O an/O evolutionarily/O conserved/O protein/O of/O unknown/O function/O ./O
These/O cells/O produced/O P2Y/I (/I 11/I )/I mRNA/I during/O culture/O ./O
Coexpression/O studies/O indicate/O that/O insulin/I and/O PKB/I suppress/O transactivation/O by/O C/I //I EBPbeta/I ,/O but/O not/O C/I //I EBPalpha/I ,/O and/O that/O N/O -/O terminal/O transactivation/O domains/O in/O C/I //I EBPbeta/I are/O required/O ./O
Among/O eight/O graminaceous/O species/O tested/O ,/O Ids3/I expression/O was/O observed/O only/O in/O Fe/O -/O deficient/O roots/O of/O H/O ./O vulgare/O and/O Secale/O cereale/O ./O which/O not/O only/O secrete/O 2/O '-/O deoxymugineic/O acid/O (/O DMA/O ),/O but/O also/O mugineic/O acid/O (/O MA/O )/O and/O 3/O -/O epihydroxymugineic/O acid/O (/O epiHMA/O ,/O H/O ./O vulgare/O ),/O and/O 3/O -/O hydroxymugineic/O acid/O (/O HMA/O ,/O S/O ./O cereale/O )./O
In/O contrast/O ,/O high/O COUP/I -/I TFI/I expression/O impeded/O the/O neuronal/O differentiation/O of/O P19/O cells/O induced/O with/O RA/O ,/O resulting/O in/O cell/O cultures/O lacking/O neurons/O ./O
Because/O PET/O is/O also/O useful/O for/O the/O pretreatment/O and/O follow/O -/O up/O evaluation/O ,/O the/O use/O of/O stereotactic/O PET/O in/O these/O patients/O can/O enable/O an/O accurate/O comparison/O of/O PET/O -/O based/O metabolic/O data/O with/O MR/O -/O based/O anatomical/O data/O ./O
Therefore/O ,/O in/O our/O in/O vitro/O model/O ,/O the/O localization/O of/O the/O mutation/O in/O the/O K/I -/I ras/I gene/I predisposes/O to/O a/O different/O level/O of/O aggressiveness/O in/O the/O transforming/O phenotype/O ./O
Here/O ,/O we/O describe/O the/O isolation/O of/O MdPin1/I ,/O a/O Pin1/I homologue/O from/O the/O plant/O species/O apple/O (/O Malus/O domestica/O )/O and/O show/O that/O it/O has/O the/O same/O phosphorylation/O -/O specific/O substrate/O specificity/O and/O can/O be/O inhibited/O by/O juglone/O in/O vitro/O ,/O as/O is/O the/O case/O for/O Pin1/I ./O
Differential/O association/O of/O products/O of/O alternative/O transcripts/O of/O the/O candidate/O tumor/I suppressor/I ING1/I with/O the/O mSin3/I //O HDAC1/I transcriptional/O corepressor/O complex/O ./O
These/O and/O other/O data/O presented/O suggest/O that/O TAg/I '/O re/O -/O models/O '/O host/O cell/O transcription/O factors/O that/O are/O used/O early/O in/O viral/O infection/O ,/O and/O thereby/O mimics/O an/O event/O that/O naturally/O occurs/O during/O transformation/O ./O
This/O sensitivity/O analysis/O showed/O that/O the/O practical/O limits/O of/O the/O accuracy/O of/O the/O used/O screening/O test/O jeopardize/O the/O estimation/O of/O the/O true/O herd/O prevalence/O within/O reasonable/O confidence/O limits/O ,/O because/O the/O within/O -/O herd/O PTB/O true/O prevalence/O was/O low/O ./O For/O this/O reason/O we/O augmented/O the/O herd/O specificity/O for/O herds/O with/O larger/O adult/O herd/O size/O (>/O 5/O )./O
ORFK10/I ./I 5/I encodes/O a/O protein/O ,/O latency/I -/I associated/I nuclear/I antigen/I 2/I (/O LANA2/I ),/O which/O is/O expressed/O in/O KSHV/O -/O infected/O hematopoietic/O tissues/O ,/O including/O PEL/O and/O CD/O but/O not/O KS/O lesions/O ./O
As/O hypothesized/O ,/O believers/O showed/O relatively/O higher/O right/O hemispheric/O activation/O and/O reduced/O hemispheric/O asymmetry/O of/O functional/O complexity/O ./O
In/O Xenopus/O ,/O BMPs/I act/O as/O epidermal/O inducers/O and/O also/O as/O negative/O regulators/O of/O neurogenesis/O ./O
Presently/O four/O unique/O variants/O carrying/O distinct/O GAF/I sequences/I in/O the/O N/O -/O terminal/O region/O have/O been/O identified/O ./O
Genomic/O organization/O of/O the/O human/O phosphodiesterase/I PDE11A/I gene/I ./O
The/O present/O findings/O revealed/O that/O the/O rib/I -/I 2/I protein/I was/O a/O unique/O alpha1/I ,/I 4/I -/I N/I -/I acetylglucosaminyltransferase/I involved/O in/O the/O biosynthetic/O initiation/O and/O elongation/O of/O heparan/O sulfate/O ./O
Inhibition/O of/O the/O Mek/I //O Erk/I pathway/O in/O Rat1/O //O ras/I cells/O ,/O using/O the/O Mek/I inhibitor/O ,/O PD98059/O ,/O resulted/O in/O complete/O cytoskeletal/O recovery/O ,/O indistinguishable/O from/O that/O induced/O by/O HR12/O ./O
The/O transcription/O factor/O CHOP/I //O GADD153/I gene/O is/O induced/O by/O cellular/O stress/O and/O is/O involved/O in/O mediating/O apoptosis/O ./O
Addition/O of/O synthetic/O tyrosine/O -/O phosphorylated/O peptides/O derived/O from/O betac/O cytoplasmic/O tyrosines/O prior/O to/O GM/I -/I CSF/I stimulation/O inhibited/O the/O in/O vitro/O activation/O of/O STAT5/I ./O
MAIN/O OUTCOME/O MEASURES/O :/O Percentage/O change/O in/O the/O apnea/O -/O hypopnea/O index/O (/O AHI/O ;/O apnea/O events/O +/O hypopnea/O events/O per/O hour/O of/O sleep/O )/O and/O odds/O of/O developing/O moderate/O -/O to/O -/O severe/O SDB/O (/O defined/O by/O an/O AHI/O >/O or/O =/O 15/O events/O per/O hour/O of/O sleep/O ),/O with/O respect/O to/O change/O in/O weight/O ./O
Paraneoplastic/O rheumatic/O syndromes/O ./O
This/O article/O reviews/O recent/O information/O on/O the/O frequency/O ,/O characteristics/O ,/O and/O possible/O pathogenic/O mechanisms/O of/O the/O vasculitides/O occurring/O in/O patients/O with/O the/O main/O connective/O tissue/O diseases/O ./O
Tec/I kinase/I signaling/O in/O T/O cells/O is/O regulated/O by/O phosphatidylinositol/I 3/I -/I kinase/I and/O the/O Tec/I pleckstrin/I homology/I domain/I ./O
Current/O evidence/O for/O this/O type/O of/O DNA/O supercoiling/O -/O dependent/O transcriptional/O coupling/O ,/O based/O largely/O on/O the/O in/O vivo/O activities/O of/O promoters/O contained/O in/O engineered/O DNA/O constructs/O ,/O suggests/O that/O the/O transcription/O complex/O must/O be/O physically/O hindered/O to/O generate/O DNA/O supercoils/O and/O to/O prevent/O their/O diffusion/O throughout/O the/O DNA/O duplex/O ./O
The/O structure/O of/O the/O free/O SH2/I domain/I has/O been/O compared/O to/O that/O of/O the/O SH2/I complexed/O with/O a/O doubly/O phosphorylated/O peptide/O derived/O from/O polyomavirus/I middle/I T/I antigen/I (/O MT/I )./O
We/O have/O identified/O three/O binding/O sites/O for/O protein/O complexes/O :/O a/O palindrome/O ,/O a/O direct/O repeat/O ,/O and/O a/O C/O +/O T/O sequence/O that/O corresponds/O to/O seven/O GAGA/O motifs/O on/O the/O transcribed/O strand/O ./O
Copyright/O 2000/O Academic/O Press/O ./O
Nucleotide/O sequence/O ,/O genome/O organization/O and/O phylogenetic/O analysis/O of/O pineapple/O mealybug/O wilt/O -/O associated/O virus/O -/O 2/O ./O
Patients/O underwent/O pretreatment/O cystoscopy/O and/O detailed/O tumor/O mapping/O ,/O and/O were/O treated/O with/O 75/O mg/O ./O //O m/O ./O 2/O cisplatin/O on/O day/O 1/O and/O 1/O gm/O .//O m/O ./O 2/O daily/O ,/O 5/O -/O fluorouracil/O on/O days/O 1/O to/O 4/O and/O definitive/O radiotherapy/O ./O
All/O 9/O untreated/O patients/O underwent/O laparoscopy/O ,/O which/O identified/O 3/O intra/O -/O abdominal/O ,/O 3/O vanished/O and/O 2/O peeping/O testes/O ,/O and/O 1/O atrophic/O testis/O in/O the/O inguinal/O canal/O ./O
This/O philosophy/O was/O instituted/O for/O the/O compound/O RP/O 73401/O ,/O a/O specific/O phosphodiesterase/I IV/I inhibitor/O ,/O that/O was/O being/O developed/O simultaneously/O for/O delivery/O by/O both/O oral/O and/O pulmonary/O routes/O of/O administration/O ./O
Increased/O levels/O of/O anticardiolipin/I immunoglobulin/I G/I may/O also/O cause/O bleeding/O ./O
RESULTS/O :/O Prevalence/O of/O obesity/O (/O BMI/O SDS/O >/O 2/O ./O 0/O )/O was/O /O A/O ,/O in/O a/O German/O USH1/I patient/O ./O
Closeup/O :/O a/O resource/O for/O nurses/O who/O smoke/O ./O
[/O 18F/O ](+)-/O 4/O -/O fluorobenzyltrozamicol/O (/O FBT/O ),/O which/O selectively/O binds/O to/O the/O vesicular/O acetylcholine/I transporter/I in/O the/O presynaptic/O cholinergic/O neuron/O ,/O has/O previously/O been/O shown/O to/O be/O a/O useful/O ligand/O for/O the/O study/O of/O cholinergic/O terminal/O density/O in/O the/O basal/O ganglia/O with/O PET/O ./O
We/O demonstrate/O that/O the/O protein/O is/O a/O murine/I homologue/I of/I SAF/I -/I A/I which/O has/O been/O shown/O to/O bind/O selectively/O to/O MARs/O and/O is/O responsible/O for/O the/O satMa/I -/O binding/O activity/O in/O the/O chromatographic/O fractions/O ./O
The/O molecular/O associations/O dictating/O INCENP/I behavior/O during/O mitosis/O are/O currently/O unknown/O ./O
Ang/I II/I significantly/O induced/O Ang2/I mRNA/I accumulations/O without/O affecting/O Ang1/I or/O Tie2/I expression/O ,/O which/O was/O inhibited/O by/O protein/I kinase/I C/I inhibitors/O and/O by/O intracellular/O Ca/O (/O 2/O +)/O chelating/O agents/O ./O
Promoter/O analysis/O demonstrated/O that/O the/O sequence/O identical/O to/O consensus/O cAMP/O -/O responsive/O element/O (/O CRE/O )/O located/O at/O -/O 481/O of/O the/O SMemb/I promoter/I was/O critical/O for/O Hex/I responsiveness/O ./O
LH/I //I CG/I receptor/I activation/O of/O ARNO/I is/O not/O mediated/O by/O activation/O of/O phosphatidylinositol/I 3/I -/I kinase/I (/O PI/I 3/I -/I kinase/I )/O or/O by/O G/I protein/I beta/I gamma/I subunits/I ./O
Deletion/O analysis/O showed/O that/O the/O -/O 321/O /+/O 41/O sequence/O was/O sufficient/O for/O both/O the/O constitutive/O promoter/O activity/O and/O auto/O -/O activation/O and/O electrophoretic/O mobility/O shift/O assays/O identified/O the/O interaction/O of/O C/I //I EBPs/I and/O Sp1/I to/O this/O region/O ./O
Termination/O of/O induced/O VT/O on/O the/O first/O attempt/O was/O comparable/O with/O BV/O pacing/O (/O 87/O ./O 4/O %)/O versus/O RV/O pacing/O (/O 89/O ./O 6/O %)./O
We/O compare/O the/O results/O of/O this/O algorithm/O with/O the/O results/O obtained/O with/O two/O other/O algorithms/O ,/O the/O optimal/O algorithm/O for/O monochannel/O nonoverlapping/O noise/O and/O the/O optimal/O algorithm/O for/O multichannel/O additive/O noise/O ,/O and/O we/O show/O that/O in/O both/O cases/O improvement/O can/O be/O obtained/O ./O
Changes/O in/O stimulation/O levels/O over/O time/O in/O nucleus/O 22/O cochlear/O implant/O users/O ./O
Nuclease/O probing/O and/O structure/O -/O directed/O mutagenesis/O revealed/O that/O the/O 105/O -/O nt/O TE/O (/O TE105/O )/O forms/O a/O cruciform/O secondary/O structure/O containing/O four/O helices/O connected/O by/O single/O -/O stranded/O regions/O ./O
Tele/O -/O Talk/O has/O the/O extra/O capability/O of/O operating/O in/O live/O conference/O situations/O using/O microphone/O input/O ./O
A/O marked/O decrease/O in/O the/O type/I 1/I insulin/I -/I like/I growth/I factor/I (/I IGF/I )/I receptor/I (/O IGF/I -/I IR/I )/O occurs/O in/O prostate/O epithelial/O cells/O during/O transformation/O from/O the/O benign/O to/O the/O metastatic/O state/O ./O
The/O P69/O cell/O line/O was/O derived/O by/O immortalization/O of/O human/O primary/O prostate/O epithelial/O cells/O with/O simian/I virus/I -/I 40/I T/I antigen/I and/O is/O rarely/O tumorigenic/O ./O
We/O determined/O whether/O the/O human/I StAR/I promoter/I is/O responsive/O to/O sterol/I regulatory/I element/I -/I binding/I proteins/I (/O SREBPs/I )./O
Expression/O of/O SREBP/I -/I 1a/I stimulated/O StAR/I promoter/I activity/O in/O the/O context/O of/O COS/O -/O 1/O cells/O and/O human/O granulosa/O -/O lutein/O cells/O ./O
Because/O the/O high/I -/I density/I lipoprotein/I receptor/I (/O HDL/I -/I R/I )/O is/O a/O key/O element/O in/O cholesterol/O homeostasis/O and/O a/O potential/O therapeutic/O target/O for/O hypercholesterolemic/O drugs/O ,/O an/O understanding/O of/O HDL/I -/I R/I regulation/O is/O essential/O ./O
IFN/I -/I stimulated/I gene/I factor/I -/I 3/I and/O STAT1/I homodimers/I formed/O and/O bound/O an/O IFN/I -/I stimulated/I response/I element/I (/O ISRE/I )/O and/O gamma/I -/I activated/I sequence/I (/O GAS/I )/O element/O ,/O respectively/O ./O
We/O have/O therefore/O studied/O the/O molecular/O mechanisms/O of/O TGF/I -/I beta1/I action/O on/O thyroglobulin/I (/O TG/I )/O gene/O expression/O by/O focusing/O our/O attention/O on/O TGF/I -/I beta1/I regulation/O of/O thyroid/O -/O specific/O transcription/O factors/O ./O
The/O epitope/O -/O protected/O lysine/O (/O K/O )/O was/O present/O in/O a/O 30/I -/I aa/I TPO/I fragment/I that/O ,/O by/O N/O -/O terminal/O sequencing/O ,/O was/O found/O to/O be/O K713/O ./O
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FILE: src/genetagger/gene.validate
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BACKGROUND/O :/O Ischemic/O heart/O disease/O is/O the/O primary/O cause/O of/O morbidity/O and/O mortality/O among/O diabetics/O ,/O especially/O those/O who/O became/O ill/O at/O a/O young/O age/O ./O
More/O importantly/O ,/O this/O fusion/O converted/O a/O less/O effective/O vaccine/O into/O one/O with/O significant/O potency/O against/O established/O E7/I -/O expressing/O metastatic/O tumors/O ./O
Reverse/O transcription/O -/O PCR/O analysis/O of/O mRNA/O from/O patients/O shows/O that/O each/O of/O these/O five/O mutations/O results/O in/O aberrant/O splicing/O ./O
Using/O the/O postural/O and/O force/O data/O as/O input/O to/O a/O 3/O -/O D/O biomechanical/O model/O ,/O the/O lumbosacral/O spinal/O compression/O was/O calculated/O ./O
Sequence/O analysis/O revealed/O significant/O differences/O between/O the/O 5/O '/O region/O of/O the/O beta/O subunit/O gene/O and/O the/O corresponding/O regions/O of/O the/O homologous/I GlyR/I alpha/I subunit/I genes/I ;/O it/O also/O identified/O a/O novel/O exon/O (/O exon/O 0/O )/O that/O encodes/O most/O of/O the/O 5/O '-/O untranslated/O portion/O of/O the/O GlyR/I beta/I mRNA/I ./O
Therefore/O ,/O we/O suggested/O that/O both/O proteins/O might/O belong/O to/O the/O PLTP/I family/I ./O
Influence/O of/O compression/O therapy/O on/O symptoms/O following/O soft/O tissue/O injury/O from/O maximal/O eccentric/O exercise/O ./O
STAT5A/I mutations/O in/O the/O Src/I homology/I 2/I (/O SH2/I )/O and/O SH3/I domains/I did/O not/O alter/O the/O BTK/I -/O mediated/O tyrosine/O phosphorylation/O ./O
In/O the/O present/O work/O ,/O the/O complete/O genome/O sequences/O of/O Pyrococcus/O horikoshii/O and/O Pyrococcus/O abyssi/O ,/O two/O species/O in/O a/O genus/O of/O hyperthermophilic/O archaeon/O (/O archaebacterium/O ),/O were/O compared/O to/O detect/O large/O genome/O polymorphisms/O linked/O with/O restriction/O -/O modification/O gene/O homologs/O ./O
In/O addition/O ,/O these/O patients/O show/O both/O quantitative/O and/O qualitative/O differences/O in/O their/O infectious/O microbiological/O spectrum/O ,/O mainly/O in/O clean/O -/O contaminated/O ,/O contaminated/O and/O dirty/O surgical/O procedures/O ./O
Here/O we/O show/O that/O PKC/I and/O p44/I //O p42MAPK/I signalings/O are/O required/O for/O the/O HBx/I -/O induced/O Sp1/I -/O mediated/O IGF/I -/I II/I P4/I transcriptional/O activity/O since/O (/O i/O )/O PKC/I activation/O by/O PMA/O or/O PKC/I expression/O vector/O increases/O Sp1/I phosphorylation/O and/O P4/I activity/O in/O HBx/I -/O transfected/O HepG2/O cells/O ;/O (/O ii/O )/O PKC/I inhibition/O by/O PKC/I inhibitor/O Go6976/O reduces/O Sp1/I phosphorylation/O ,/O P4/I activity/O ,/O and/O IGF/I -/I II/I mRNA/I in/O HBx/I -/O transfected/O HepG2/O cells/O ;/O and/O (/O iii/O )/O the/O inhibition/O of/O MEK/I activation/O by/O U0126/O reduces/O Sp1/I phosphorylation/O ,/O P4/I activity/O and/O IGF/I -/I II/I mRNA/I in/O HBx/I -/O transfected/O HepG2/O cells/O ./O
We/O show/O that/O p73/I can/O transcriptionally/O inhibit/O a/O number/O of/O cellular/O and/O viral/O promoters/O ./O
Similarly/O ,/O curcumin/O (/O diferuloylmethane/O ),/O an/O anti/O -/O inflammatory/O agent/O ,/O suppressed/O OSM/I -/O stimulated/O STAT1/I phosphorylation/O ,/O DNA/O -/O binding/O activity/O of/O STAT1/I ,/O and/O c/I -/I Jun/I N/I -/I terminal/I kinase/I activation/O without/O affecting/O JAK1/I ,/O JAK2/I ,/O JAK3/I ,/O ERK1/I //I 2/I ,/O and/O p38/I phosphorylation/O ./O
The/O effects/O of/O the/O transfected/O receptors/O were/O associated/O with/O antagonism/O of/O activator/I protein/I 1/I (/O AP/I -/I 1/I )/O activity/O ./O
Furthermore/O ,/O the/O soluble/O forms/O of/O ATF6/I and/O the/O G13/I gene/I product/I are/O unable/O to/O bind/O to/O several/O point/O mutants/O of/O the/O cis/O -/O acting/O ER/O stress/O response/O element/O in/O vitro/O that/O hardly/O respond/O to/O ER/O stress/O in/O vivo/O ./O
PURPOSE/O :/O The/O objective/O of/O this/O study/O was/O to/O assess/O first/O embryo/O cleavage/O (/O FEC/O )/O 25/O -/O 27/O h/O after/O intracytoplasmic/O sperm/O injection/O (/O ICSI/O )/O as/O a/O parameter/O for/O the/O embryo/O selection/O process/O ./O
RESULTS/O :/O A/O significant/O correlation/O (/O p/O /O or/O =/O grade/O 3/O acute/O toxicity/O (/O RTOG/O )./O
We/O hypothesize/O that/O proprioception/O may/O be/O used/O to/O calibrate/O the/O efference/O copy/O during/O development/O and/O in/O response/O to/O perturbations/O by/O signaling/O potential/O mismatches/O between/O eye/O movement/O information/O derived/O from/O the/O efferent/O command/O and/O the/O actual/O motion/O of/O the/O eye/O transduced/O by/O the/O proprioceptive/O organs/O ./O
Thus/O ,/O BALB/O //O c/O mice/O appear/O to/O be/O the/O most/O appropriate/O strain/O of/O mice/O to/O perform/O studies/O on/O the/O possible/O connection/O between/O infection/O with/O T/O ./O canis/O and/O allergic/O asthma/O ./O
They/O correspond/O to/O nucleotides/O equivalent/O to/O base/O -/O pair/O C1/O -/O G72/O and/O discriminator/O base/O A73/O in/O the/O amino/O acid/O -/O acceptor/O branch/O of/O the/O molecule/O ./O
Our/O results/O suggest/O that/O the/O central/O role/O of/O the/O Notch/I -/O CBF1/I //O RBP/I -/I Jkappa/I signaling/O pathway/O in/O cell/O fate/O decisions/O renders/O it/O susceptible/O to/O pathways/O of/O viral/O replication/O and/O oncogenic/O conversion/O ./O
High/O -/O affinity/O binding/O of/O NF/I -/I 1/I to/O PSE/I -/I B/I ,/O but/O not/O to/O PSE/I -/I A/I ,/O was/O confirmed/O by/O competition/O of/O DNA/O -/O protein/O interactions/O by/O using/O NF/I -/I 1/I DNA/O elements/O and/O antibodies/O ./O
The/O first/O case/O of/O HCV/O seroconversion/O in/O Portugal/O after/O the/O introduction/O of/O HCV/O NAT/O screening/O ./O
Substitutions/O in/O the/O YFV/I Ag/I -/I binding/I region/I (/O ABR/I )/O occur/O at/O four/O of/O the/O eight/O highly/O conserved/O residues/O that/O are/O essential/O for/O binding/O of/O peptide/O -/O Ag/O in/O the/O class/O Ia/O molecules/O ./O
The/O Novacor/O Left/O Ventricular/O Assist/O System/O (/O LVAS/O )/O (/O Novacor/O Corp/O ,/O Oakland/O ,/O CA/O )/O was/O initially/O console/O -/O based/O and/O has/O been/O available/O since/O 1993/O in/O a/O wearable/O configuration/O ./O
Ileal/O digestibilities/O of/O DM/O ,/O OM/O ,/O CP/O ,/O total/O dietary/O fiber/O (/O TDF/O ),/O fat/O and/O gross/O energy/O (/O GE/O )/O were/O lower/O (/O P/O /O 30/O mm/O Hg/O )/O herniation/O occurs/O ,/O usually/O within/O 2/O to/O 5/O days/O ./O
The/O present/O data/O also/O demonstrate/O that/O ectopic/O expression/O of/O blr1/I increased/O JNK/I //O SAPK/I activity/O ,/O but/O JNK/I //O SAPK/I activation/O was/O not/O needed/O for/O accelerated/O RA/O -/O induced/O differentiation/O and/O growth/O arrest/O ./O
Here/O ,/O we/O identify/O Rsc3/I and/O Rsc30/I as/O novel/O components/O of/O the/O essential/O yeast/I remodeler/I RSC/I complex/I ./O
The/O pharmacokinetic/O profiles/O of/O digoxin/O and/O warfarin/O were/O not/O altered/O by/O the/O simultaneous/O and/O continued/O administration/O of/O sevelamer/O ./O
Forskolin/O treatment/O (/O 10/O microM/O )/O of/O the/O transfected/O cells/O for/O 3/O --/O 6/O h/O maximally/O induced/O luciferase/I threefold/O ./O
E2F1/I -/O mediated/O transcriptional/O inhibition/O of/O the/O plasminogen/I activator/I inhibitor/I type/I 1/I gene/I ./O
In/O this/O report/O this/O technique/O was/O applied/O to/O human/O breast/O carcinoma/O MDA/O -/O MB231/O cells/O overexpressing/O human/I MPG/I in/O order/O to/O assess/O whether/O up/O -/O regulation/O of/O the/O initial/O step/O in/O BER/O alters/O the/O activity/O of/O selected/O other/O BER/O (/O hOGG1/I and/O APE/I //O ref/I -/I 1/I )/O or/O direct/O reversal/O (/O MGMT/I )/O repair/O activities/O ./O
Chlamydia/O and/O cervical/O cancer/O :/O a/O real/O association/O ?/O
In/O children/O unable/O to/O perform/O forced/O expiratory/O maneuvers/O (/O n/O =/O 25/O ),/O FOT/O ,/O contrary/O to/O the/O interrupter/O technique/O ,/O clearly/O identified/O a/O subgroup/O of/O young/O children/O with/O high/O resistance/O values/O at/O baseline/O ,/O which/O returned/O to/O normal/O after/O bronchodilation/O ./O
Together/O ,/O these/O results/O identify/O HPK1/I as/O a/O new/O component/O of/O TCR/I signaling/O ./O
Pro/O -/O inflammatory/O cytokine/O ,/O tumor/I necrosis/I factor/I -/I alpha/I (/O TNF/I -/I alpha/I ),/O produced/O from/O adipose/O tissues/O in/O obese/O subjects/O ,/O is/O known/O to/O play/O a/O predominant/O role/O in/O inducing/O insulin/I resistance/O ./O
The/O Schistosoma/I mansoni/I homologue/I (/O SmSmad2/I )/O was/O overexpressed/O in/O bacteria/O as/O a/O Sj26/I -/O GST/I fusion/O protein/O and/O used/O to/O raise/O specific/O antibodies/O ./O
To/O study/O the/O in/O vivo/O role/O of/O p16/I ./I 7/I ,/O a/O phi29/O mutant/O containing/O a/O suppressible/O mutation/O in/O gene/I 16/I ./I 7/I was/O constructed/O ./O
The/O differences/O in/O the/O CPIgG/I ,/O CRP/I ,/O and/O fibrinogen/I levels/O in/O patients/O who/O were/O diagnosed/O with/O ACS/O versus/O those/O who/O were/O not/O (/O non/O -/O ACS/O )/O were/O evaluated/O ./O
There/O are/O many/O different/O proposals/O for/O the/O statistical/O analysis/O of/O data/O to/O determine/O early/O onset/O of/O action/O ./O
Coexpression/O of/O the/O p120/I (/O ctn/I )/O protein/O with/O an/O N/O -/O terminal/O deletion/O ,/O which/O eliminates/O some/O potential/O tyrosine/O phosphorylation/O sites/O ,/O or/O the/O protein/O with/O a/O single/O amino/O acid/O substitution/O (/O tyrosine/O at/O 217/O to/O phenylalanine/O )/O resulted/O in/O an/O increase/O in/O the/O aggregation/O of/O v/I -/I Src/I -/O transformed/O EL/O and/O EalphaCL/O cells/O ./O
We/O find/O that/O our/O response/O function/O is/O well/O approximated/O by/O the/O GSER/O only/O within/O a/O particular/O frequency/O range/O determined/O by/O the/O material/O parameters/O of/O both/O the/O bead/O and/O the/O network/O ./O
The/O novel/O approach/O to/O insulin/I administration/O known/O as/O chronic/O intermittent/O intravenous/O insulin/I therapy/O (/O CIIIT/O )/O delivers/O insulin/I in/O a/O pulsatile/O fashion/O and/O achieves/O physiological/O insulin/I concentration/O in/O the/O portal/O vein/O ./O
This/O article/O comparatively/O evaluates/O five/O Generic/O Systems/O that/O describe/O the/O basic/O alternatives/O to/O composting/O facility/O design/O and/O control/O ./O
With/O a/O GC/O content/O of/O 45/O %/O the/O one/O segment/O would/O correspond/O to/O "/I isochore/I H1/I "/I and/O the/O other/O segment/O (/O 39/O %/O GC/O in/O human/O ,/O 40/O %/O GC/O in/O mouse/O )/O to/O "/O isochore/O L1/I //O L2/I "./O
A/O review/O of/O the/O literature/O identified/O 8/O comprehensive/O clinical/O studies/O ,/O all/O of/O which/O failed/O to/O document/O any/O relationship/O between/O NF1/I and/O intracranial/O aneurysms/O ./O
Serial/O US/O images/O were/O obtained/O before/O and/O 20/O ,/O 30/O ,/O 40/O ,/O 50/O ,/O 60/O ,/O 90/O ,/O 120/O ,/O 150/O ,/O 180/O ,/O 240/O ,/O and/O 300/O s/O after/O intravenous/O injection/O of/O 2/O g/O of/O contrast/O agent/O using/O conventional/O and/O harmonic/O PD/O US/O ./O
Eight/O CAD/O patients/O who/O were/O matched/O to/O the/O treated/O patients/O for/O age/O (+/-/O 3/O years/O ),/O baseline/O low/I density/I lipoprotein/I (+/-/O 5/O mg/O //O dL/O ),/O and/O triglycerides/O (+/-/O 50/O mg/O //O dL/O )/O but/O who/O had/O never/O been/O treated/O with/O lipid/O -/O lowering/O drugs/O were/O selected/O as/O controls/O ./O
Here/O we/O present/O evidence/O that/O the/O distal/O half/O (/O Stem/O 2/O )/O of/O the/O conserved/O base/O -/O paired/O stem/O structure/O found/O in/O all/O hY/I RNAs/I also/O plays/O a/O critical/O role/O in/O the/O export/O process/O ./O
The/O contrasting/O effects/O of/O dopaminergic/O stimulation/O on/O the/O motor/O performance/O and/O on/O some/O aspects/O of/O cognitive/O processing/O suggest/O the/O existence/O of/O complex/O interactions/O within/O pre/O -/O and/O postsynaptic/O brain/I dopamine/I receptors/I ,/O and/O an/O intervention/O of/O segregated/O basal/O ganglia/O -/O prefrontal/O cortex/O loops/O in/O motor/O and/O cognitive/O behaviour/O ./O
The/O size/O of/O the/O infarct/O was/O determined/O using/O the/O creatine/I kinase/I integral/O method/O ./O
These/O corrections/O do/O not/O involve/O sequences/O predicted/O to/O function/O as/O transcription/O factor/O binding/O sites/O ./O
A/O comprehensive/O neuropsychological/O battery/O was/O administered/O to/O 48/O veterans/O with/O Gulf/O War/O Illness/O (/O GWI/O )/O characterized/O by/O severe/O fatigue/O (/O GV/O -/O F/O )/O and/O 39/O healthy/O veterans/O (/O GV/O -/O H/O )./O
Quantitative/O PCR/O studies/O indicated/O that/O synthesis/O and/O transport/O of/O vector/O DNA/O into/O the/O nucleus/O were/O similar/O for/O macrophages/O infected/O with/O the/O clone/O 239/O and/O 316/O pseudotypes/O ,/O suggesting/O that/O the/O restriction/O for/O SIVmac239/O infection/O is/O after/O reverse/O transcription/O and/O nuclear/O import/O of/O viral/O DNA/O ./O
EXAFS/O measurements/O around/O the/O Ge/O -/O K/O edge/O have/O been/O carried/O out/O for/O liquid/O Ge/O -/O Si/O alloys/O for/O the/O first/O time/O to/O investigate/O the/O local/O structure/O around/O a/O Ge/O atom/O ./O
Hp/O positive/O relatives/O of/O gastric/O cancer/O had/O a/O markedly/O higher/O prevalence/O of/O atrophy/O than/O those/O with/O Hp/O negativity/O without/O cancer/O relatives/O (/O 29/O vs/O ./O
Thus/O ,/O replication/O fork/O movement/O near/O HML/I pauses/O at/O a/O silent/O origin/O which/O is/O competent/O for/O replication/O initiation/O but/O kept/O silent/O through/O Orc2p/I ,/O a/O component/O of/O the/O replication/O initiator/O ./O
Cardiac/O markers/O troponin/I T/I ,/O CK/I -/O MB/I mass/O and/O myoglobin/I were/O helpful/O in/O the/O differential/O diagnosis/O of/O chest/O pain/O ,/O even/O when/O the/O ECG/O was/O unremarkable/O or/O nonspecific/O ./O
RESULTS/O :/O A/O novel/O gene/O was/O cloned/O ./O
Both/O pancreatic/O and/O intestinal/O cell/O lines/O were/O found/O to/O express/O a/O number/O of/O POU/I (/O OCT/I binding/O )/O homeodomain/O proteins/O examined/O by/O electrophoretic/O mobility/O shift/O assay/O ./O
In/O conclusion/O ,/O USPIO/O -/O enhanced/O MRI/O data/O were/O capable/O to/O characterize/O tumor/O microvessel/O properties/O in/O this/O breast/O cancer/O model/O :/O microvascular/O permeability/O (/O determined/O using/O USPIO/O )/O correlated/O significantly/O with/O tumor/O grade/O ./O
Radiolabeled/O biantennary/O N/O -/O glycans/O synthesized/O by/O Pro/O (-)/O 5Lec20/O were/O proportionately/O less/O ricin/O -/O bound/O than/O similar/O species/O from/O parental/O CHO/O cells/O ,/O and/O Lec20/O cell/O extracts/O had/O a/O markedly/O reduced/O ability/O to/O transfer/O Gal/O to/O GlcNAc/O -/O terminating/O acceptors/O ./O
CONCLUSION/O :/O The/O training/O of/O novices/O using/O MIST/O -/O VR/O yields/O quantifiable/O changes/O in/O skill/O that/O are/O transferable/O to/O a/O simple/O real/O task/O and/O are/O similar/O to/O the/O results/O achieved/O with/O conventional/O training/O ./O
To/O investigate/O the/O convergent/O role/O of/O the/O insulin/I //O IGF/I -/I I/I effector/O pathway/O mediating/O bihormonal/O stimulation/O of/O LDL/I receptor/I promoter/I expression/O ,/O transfected/O granulosa/O -/O luteal/O cells/O were/O pretreated/O for/O 30/O min/O with/O two/O specific/O inhibitors/O of/O phophatidylinositol/I 3/I -/I kinase/I ,/O wortmannin/O (/O 100/O nM/O )/O and/O LY/O 294002/O (/O 10/O microM/O ),/O or/O of/O mitogen/I -/I activated/I protein/I kinase/I kinase/I ,/O PD/O 98059/O (/O 50/O microM/O ),/O U0126/O (/O 10/O microM/O ),/O or/O the/O latter/O '/O s/O inactive/O derivative/O ,/O U0124/O (/O 10/O microM/O )./O
Instead/O ,/O affective/O flattening/O was/O associated/O with/O both/O dopamine/I receptor/I sensitivity/O and/O psychomotor/O slowing/O ./O
Other/O therapies/O are/O also/O available/O ,/O including/O hypertonic/O saline/O solution/O ,/O THAM/O (/O Tris/O -/O hydroxy/O -/O methyl/O -/O aminomethane/O )/O buffer/O ,/O and/O high/O -/O dose/O barbiturates/O ./O
CONCLUSION/O :/O There/O are/O no/O differences/O in/O the/O measurement/O data/O derived/O from/O this/O method/O and/O actual/O measurement/O data/O from/O an/O object/O created/O by/O the/O computer/O -/O aided/O dental/O design/O program/O ./O
NF/I -/I kappaB/I pathway/O activation/O occurs/O during/O transformation/O induced/O by/O a/O number/O of/O classical/O oncogenes/O ,/O including/O Bcr/I //O Abl/I ,/O Ras/I and/O Rac/I ,/O and/O is/O necessary/O for/O full/O transforming/O potential/O ./O
Our/O results/O indicate/O that/O Gab1/I is/O involved/O in/O the/O control/O of/O egr/I -/I 1/I expression/O regulated/O by/O insulin/I ./O
The/O human/I cytomegalovirus/I (/I HCMV/I )/I major/I immediate/I -/I early/I protein/I IE2/I is/O a/O nuclear/O phosphoprotein/O that/O is/O believed/O to/O be/O a/O key/O regulator/O in/O both/O lytic/O and/O latent/O infections/O ./O
Unexpectedly/O ,/O Arg1/I -/O expressing/O COS1/O cells/O showed/O no/O significant/O proteinase/O activity/O to/O various/O synthesized/O substrates/O under/O neutral/O or/O acidic/O conditions/O in/O this/O study/O ./O
METHODS/O :/O 126/O patients/O with/O histologically/O confirmed/O MFH/O were/O analyzed/O ./O
Regression/O analyses/O showed/O that/O SOREMP/O dream/O occurrences/O were/O significantly/O related/O to/O the/O amount/O of/O REM/O sleep/O ,/O while/O NREMP/O dream/O occurrences/O were/O related/O to/O arousals/O from/O NREM/O sleep/O ./O
[/O Diabetologia/O (/O 2001/O )/O 44/O [/O Suppl/O 3/O ]:/O B37/O -/O B44/O ]/O
RESULTS/O :/O In/O vivo/O ,/O there/O was/O a/O wide/O distribution/O with/O the/O coefficient/O of/O variation/O (/O SD/O //O mean/O x/O 100/O %)/O for/O different/O valve/O sizes/O ranging/O from/O 21/O %/O to/O 39/O %/O in/O the/O St/O Jude/O Medical/O valve/O and/O from/O 25/O %/O to/O 33/O %/O in/O the/O Omnicarbon/O valve/O ./O
A/O microsporidian/O ,/O Nosema/O algerae/O Vavra/O and/O undeen/O ,/O was/O found/O parasitizing/O larvae/O and/O adults/O of/O a/O laboratory/O colony/O of/O Culex/O pipiens/O L/O ./O originated/O from/O Gharbia/O Governorate/O ./O
Nearly/O all/O isolates/O of/O S/O ./O intermedius/O and/O most/O isolates/O of/O S/O ./O constellatus/O ,/O but/O only/O 19/O %/O of/O those/O of/O S/O ./O anginosus/O ,/O were/O associated/O with/O abscess/O ./O
One/O of/O the/O conserved/O RNA/O subdomains/O ,/O designated/O P3/I ,/O has/O previously/O been/O shown/O to/O be/O required/O for/O nucleolar/O localization/O ./O
A/O total/O of/O 25/O patients/O with/O malignant/O brain/O tumours/O were/O investigated/O ./O
Interventions/O aimed/O at/O these/O specific/O mediators/O and/O processes/O may/O be/O successful/O in/O reducing/O the/O very/O significant/O human/O and/O economic/O costs/O of/O vascular/O access/O dysfunction/O ./O
We/O used/O stored/O plasma/O samples/O from/O 409/O patients/O in/O the/O National/O Institute/O of/O Neurological/O Diseases/O and/O Stroke/O (/O NINDS/O )/O tissue/I plasminogen/I activator/I (/O t/I -/I PA/I )/O Stroke/O Trial/O to/O examine/O the/O relationship/O between/O an/O apolipoprotein/I (/I Apo/I )/I E2/I or/O an/O Apo/I E4/I phenotype/O and/O a/O favorable/O outcome/O 3/O months/O after/O stroke/O ,/O the/O risk/O of/O intracerebral/O hemorrhage/O ,/O and/O the/O response/O to/O intravenous/O t/I -/I PA/I therapy/O ./O
These/O results/O were/O robust/O to/O changes/O in/O the/O baseline/O assumptions/O of/O the/O model/O ./O
Cis/O -/O acting/O CCAAT/O elements/O are/O frequently/O found/O in/O eukaryotic/O promoter/O regions/O ./O
The/O binary/O and/O tertiary/O combinations/O of/O plant/O -/O derived/O molluscicides/O Azadirachta/O indica/O and/O Cedrus/O deodara/O oil/O with/O synergists/O MGK/O -/O 264/O ,/O piperonyl/O butoxide/O (/O PB/O )/O and/O fruit/O powder/O of/O Embelia/O ribes/O were/O used/O against/O the/O Lymnaea/O acuminata/O ./O
This/O article/O reports/O the/O design/O and/O development/O of/O an/O ECG/O simulator/O intended/O for/O use/O in/O the/O testing/O ,/O calibration/O and/O maintenance/O of/O electrocardiographic/O equipment/O ./O
Exchanging/O the/O human/O propeptide/O in/O this/O chimera/O with/O either/O the/O murine/I MIC/I -/I 1/I or/O TGF/I -/I beta1/I propeptide/I resulted/O in/O secretion/O of/O the/O unprocessed/O ,/O monomeric/O chimera/O ,/O suggesting/O a/O specific/O interaction/O between/O the/O human/I MIC/I -/I 1/I propeptide/I and/O mature/O peptide/O ./O
RESULTS/O :/O The/O analyzed/O fragment/O has/O significant/O activity/O in/O EpCAM/I positive/O cells/O ,/O and/O it/O is/O regulated/O negatively/O by/O tumor/I necrosis/I factor/I alpha/I (/O TNFalpha/I )./O
The/O mutant/O receptors/O ,/O as/O well/O as/O sBMPR/I -/I IA/I ,/O were/O expressed/O as/O fusion/O proteins/O with/O thioredoxin/I in/O Escherichia/O coli/O ,/O and/O purified/O using/O reverse/O phase/O high/O performance/O liquid/O chromatography/O (/O RP/O -/O HPLC/O )/O after/O digestion/O with/O enterokinase/I ./O
The/O dual/O specificity/O kinases/O mitogen/I -/I activated/I protein/I kinase/I (/I MAPK/I )/I kinase/I (/I MKK/I )/I 7/I and/O MKK4/I are/O the/O only/O molecules/O known/O to/O directly/O activate/O the/O stress/O kinases/O stress/I -/I activated/I protein/I kinases/I (/O SAPKs/I )//O c/I -/I Jun/I N/I -/I terminal/I kinases/I (/O JNKs/I )/O in/O response/O to/O environmental/O or/O mitogenic/O stimuli/O ./O
This/O unique/O work/O needs/O to/O be/O edited/O critically/O and/O afterwards/O translated/O into/O Urdu/O and/O other/O languages/O for/O the/O benefit/O of/O the/O present/O day/O students/O and/O scholars/O ./O
RANTES/I (/O regulated/I upon/I activation/I ,/I normally/I T/I -/I cell/I expressed/I and/I presumably/I secreted/I )/O is/O a/O CC/O chemokine/O which/O recruits/O and/O activates/O monocytes/O ,/O lymphocytes/O ,/O and/O eosinophils/O ,/O all/O cell/O types/O present/O in/O the/O lung/O inflammatory/O infiltrate/O induced/O by/O RSV/O infection/O ./O
Gabapentin/O for/O opiod/O -/O related/O myoclonus/O in/O cancer/O patients/O ./O
Recently/O ,/O it/O was/O shown/O that/O purified/O RAG1/I //I 2/I proteins/I can/O cleave/O DNA/O hairpins/O in/O vitro/O ,/O but/O the/O same/O activity/O was/O also/O described/O for/O a/O protein/O complex/O of/O the/O DNA/O repair/O proteins/O Nbs1/I //O Mre11/I //O Rad50/I ./O
APC/I -/O resistance/O was/O determined/O with/O a/O functional/O method/O with/O high/O sensitivity/O and/O specificity/O for/O the/O factor/I V/I Leiden/I mutation/I ./O
A/O picture/O is/O emerging/O showing/O a/O gradient/O of/O function/O among/O p53/I ,/O p73/I ,/O p63/I ranging/O from/O tumor/O suppression/O to/O development/O ./O
High/O plasma/I AVP/I levels/O observed/O in/O the/O two/O cases/O suggest/O that/O SSRIs/O stimulate/O AVP/I secretion/O ,/O thereby/O causing/O SIADH/O ./O
Mutation/O of/O the/O octamer/O element/O also/O significantly/O reduced/O the/O ability/O of/O HDAC1/I to/O confer/O repression/O of/O inducible/O HLA/I -/I DRA/I promoter/I activation/O ./O
Requirements/O for/O the/O nuclear/O -/O cytoplasmic/O translocation/O of/O infected/I -/I cell/I protein/I 0/I of/O herpes/O simplex/O virus/O 1/O ./O
The/O system/O ,/O designed/O to/O exploit/O the/O relatively/O constant/O small/O intestine/O transit/O time/O ,/O consists/O of/O a/O drug/O -/O containing/O core/O coated/O with/O a/O polymeric/O matrix/O formed/O by/O a/O channeling/O agent/O (/O NaCl/O ,/O mannitol/O ,/O and/O Emdex/O )/O and/O an/O inert/O polymer/O (/O Eudragit/O RS100/O )./O
The/O activity/O of/O Rac1/I leads/O to/O STAT3/I translocation/O to/O the/O nucleus/O coincident/O with/O STAT3/I -/O dependent/O gene/O expression/O ./O
Treatment/O of/O ischemic/O heart/O disease/O in/O the/O elderly/O
To/O avoid/O misinterpretations/O ,/O special/O reference/O values/O should/O be/O applied/O for/O preadolescents/O ,/O at/O least/O with/O regard/O to/O FVC/O and/O FEV1/O ./O
STUDY/O OBJECTIVE/O :/O This/O study/O assessed/O several/O methodological/O aspects/O related/O to/O the/O quality/O of/O published/O controlled/O clinical/O trials/O (/O CCTs/O )/O in/O relation/O to/O the/O participation/O of/O an/O epidemiologist/O //O biostatistician/O (/O E/O //O B/O )./O
To/O the/O best/O of/O our/O knowledge/O ,/O SNTCS/O is/O highly/O malignant/O ./O
Northern/O blot/O analysis/O with/O one/O of/O the/O PARNAs/I revealed/O a/O highly/O abundant/O signal/O of/O approximately/O 2/O ./O 0/O kilobases/O (/O kb/O )/O present/O in/O all/O cell/O lines/O tested/O ./O
The/O effect/O of/O crude/O oil/O spillage/O on/O growth/O ,/O productivity/O and/O nutrient/O uptake/O of/O maize/O (/O Zea/O mays/O L/O .)/O was/O assessed/O in/O a/O pot/O experiment/O using/O an/O Evwreni/O manifold/O sample/O of/O a/O petroleum/O development/O company/O ,/O which/O had/O a/O specific/O gravity/O of/O 0/O ./O 8778/O ./O
10/O ./O 0/O +/-/O 2/O ./O 0/O pmol/O //O 24/O h/O ,/O P/O /O B/O ,/O and/O being/O advected/O by/O hydrodynamical/O flows/O with/O time/O -/O periodic/O forcing/O ./O
Corticosteroid/O -/O mediated/O transcriptional/O inhibition/O was/O greater/O for/O MR/I //O GR/I in/O combination/O than/O for/O MR/I or/O GR/I alone/O ./O
These/O data/O define/O a/O conserved/O pathway/O wherein/O sequential/O histone/I modifications/O establish/O a/O "/O histone/I code/O "/O essential/O for/O the/O epigenetic/O inheritance/O of/O heterochromatin/O assembly/O ./O
The/O bovine/I PGHS/I -/I 2/I cDNA/I was/O cloned/O by/O a/O combination/O of/O reverse/O transcription/O -/O polymerase/O chain/O reaction/O and/O cDNA/O library/O screening/O ./O
Telomerase/I is/O a/O ribonucleoprotein/O complex/O that/O synthesizes/O telomeric/O DNA/O onto/O chromosomes/O using/O its/O RNA/O component/O as/O template/O ./O
The/O iterative/O method/O proposed/O by/O Bengtsson/O [/O Appl/O ./O
Several/O distinct/O apoptotic/O stimuli/O induce/O the/O expression/O and/O caspase/I -/O dependent/O cleavage/O of/O hTAF/I (/I II/I )/I 80/I delta/I ./O hTAF/I (/I II/I )/I 80/I delta/I ,/O unlike/O hTAF/I (/I II/I )/I 80/I ,/O forms/O a/O TFIID/I -/I like/I complex/I lacking/O hTAF/I (/I II/I )/I 31/I ./O
With/O NEU/I overexpression/O ,/O nodal/O control/O decreased/O from/O 72/O %/O to/O 34/O %/O (/O p/O =/O ./O 008/O )./O
The/O mouse/I platelet/I -/I derived/I growth/I factor/I (/I PDGF/I )/I beta/I -/I receptor/I promoter/I contains/O a/O CCAAT/O motif/O ,/O and/O NF/I -/I Y/I plays/O an/O essential/O role/O in/O its/O transcription/O ./O
Biol/O ./O
The/O loop/O domain/O of/O heat/I shock/I transcription/I factor/I 1/I dictates/O DNA/O -/O binding/O specificity/O and/O responses/O to/O heat/O stress/O ./O
This/O activation/O was/O then/O blocked/O by/O CGS/O 12066A/O ./O
Among/O the/O transcription/O factors/O known/O to/O interact/O with/O Groucho/I -/I related/I protein/I ,/O only/O RUNX1/I was/O appreciably/O downregulated/O by/O E2A/I -/O HLF/I ./O
A/O new/O intron/O of/O 476/O base/O pairs/O was/O found/O in/O the/O middle/O of/O the/O 5/O '-/O untranslated/O leader/O sequence/O and/O was/O shown/O to/O robustly/O enhance/O the/O promoter/O activity/O ./O
Our/O findings/O further/O our/O understanding/O of/O how/O ZBP/I -/I 89/I modulates/O cell/O proliferation/O and/O reveals/O a/O novel/O mechanism/O by/O which/O the/O p53/I protein/I is/O stabilized/O ./O
In/O the/O free/O -/O swimming/O rotatory/O test/O mice/O spend/O most/O of/O the/O time/O swimming/O close/O to/O the/O wall/O of/O the/O container/O attempting/O to/O escape/O from/O an/O aversive/O test/O situation/O ./O
As/O well/O ,/O mixtures/O of/O (/O LA/O )(/O 12/O )/O with/O the/O longer/O chain/O PEs/O exhibit/O unusual/O biomodal/O enthalpy/O variations/O ,/O suggesting/O peptide/O immiscibility/O in/O thicker/O gel/O state/O bilayers/O ./O
At/O the/O time/O of/O the/O blind/O therapeutic/O doses/O ,/O Tg/I -/O off/O values/O ranged/O from/O 8/O to/O 608/O microg/O //O l/O ./O
Nephrotoxicity/O after/O orthotopic/O liver/O transplantation/O in/O cyclosporin/O A/O and/O FK/O 506/O -/O treated/O patients/O ./O
In/O contrast/O to/O MPc3/I ,/O data/O indicate/O that/O the/O Pc/I protein/I M33/I does/O not/O interact/O with/O AF9/I ./O
Hydrocoele/O is/O common/O in/O men/O in/O Wuchereria/O bancrofti/O -/O endemic/O areas/O ,/O the/O treatment/O for/O which/O is/O currently/O surgical/O intervention/O ./O
Of/O the/O patients/O in/O each/O regimen/O who/O reached/O study/O end/O points/O ,/O 17/O of/O 29/O (/O 59/O %)/O were/O in/O regimen/O A/O ,/O 11/O of/O 20/O (/O 55/O %)/O were/O in/O regimen/O B/O ,/O and/O 28/O of/O 43/O (/O 65/O %)/O were/O in/O regimen/O C/O met/O the/O treatment/O success/O criterion/O ./O
One/O maternal/O death/O ,/O reduced/O body/O weight/O ,/O and/O reduced/O weight/O gain/O were/O noted/O at/O the/O high/O dose/O ;/O confirmed/O pregnancy/O rates/O were/O 84/O to/O 100/O %/O for/O each/O group/O ./O
Karger/O AG/O ,/O Basel/O
In/O regards/O to/O the/O latter/O activity/O ,/O it/O has/O been/O shown/O that/O S3/I contains/O vigorous/O N/I -/I glycosylase/I activity/O for/O the/O removal/O of/O 8/O -/O oxoguanine/O residues/O in/O DNA/O that/O leaves/O baseless/O sites/O in/O their/O places/O ./O
We/O describe/O a/O total/O of/O 39/O DEAH/I helicases/I in/O these/O four/O species/O ./O
A/O prospective/O trial/O was/O undertaken/O to/O determine/O (/O 1/O )/O clinical/O characteristics/O of/O patients/O with/O chest/O pain/O ;/O (/O 2/O )/O value/O of/O cardiac/O markers/O troponin/I T/I ,/O myoglobin/I and/O CK/I -/O MB/I mass/O in/O differentiating/O cardiac/O and/O noncardiac/O chest/O pain/O ;/O (/O 3/O )/O the/O proportion/O of/O patients/O with/O ACS/O in/O whom/O these/O markers/O provided/O helpful/O additional/O information/O on/O admission/O and/O afterwards/O ./O
Inactivity/O of/O the/O human/I cytomegalovirus/I (/I HCMV/I )/I major/I immediate/I -/I early/I regulatory/I region/I (/O MIERR/I ),/O which/O is/O composed/O of/O promoter/O ,/O enhancer/O ,/O unique/O region/O ,/O and/O modulator/O ,/O is/O linked/O to/O lack/O of/O HCMV/O replication/O in/O latently/O infected/O cells/O and/O in/O other/O nonpermissive/O cell/O types/O ,/O including/O human/O embryonal/O NTera2/O carcinoma/O (/O NT2/O )/O cells/O ./O
The/O observed/O triplexes/O depend/O on/O the/O length/O of/O the/O repeat/O ./O
Statistical/O Analysis/O included/O ANOVA/O ,/O the/O Pearson/O Product/O Moment/O Correlation/O Coefficient/O ,/O Principal/O Components/O Analysis/O and/O Discriminant/O Function/O Analysis/O and/O the/O calculation/O of/O Cronbach/O '/O s/O alpha/O (/O alpha/O )/O RESULTS/O :/O Both/O Sensitivity/O and/O specificity/O exceed/O 90/O ./O 00/O at/O 23/O //O 24/O ,/O Chronbach/O '/O s/O alpha/O for/O the/O total/O scale/O was/O equal/O to/O 0/O ./O 95/O ./O
BACKGROUND/O :/O Previous/O studies/O have/O indicated/O that/O the/O 60/O -,/O 30/O -,/O 28/O -/O and/O 12/O -/O item/O versions/O of/O the/O General/O Health/O Questionnaire/O (/O GHQ/O )/O are/O liable/O to/O retest/O effects/O ,/O especially/O when/O administered/O multiple/O times/O with/O short/O intervals/O ./O
Cross/O -/O linking/O FcalphaR/I on/O wt/I -/I ITAM/I or/O IIA/I -/I ITAM/I cells/O triggered/O equivalent/O PI/I 3/I -/I kinase/I -/O dependent/O activation/O of/O PKBalpha/I ./O
An/O F222W/I :/I W21F/I rGST/I A1/I -/I 1/I double/I mutant/I provides/O a/O direct/O fluorescence/O probe/O of/O changes/O in/O the/O environment/O of/O the/O C/O -/O terminal/O residue/O ./O
Binding/O of/O serum/I response/I factor/I to/O CArG/O box/O sequences/O is/O necessary/O but/O not/O sufficient/O to/O restrict/O gene/O expression/O to/O arterial/O smooth/O muscle/O cells/O ./O
They/O consist/O of/O at/O least/O two/O separable/O components/O ,/O one/O heat/O stable/O and/O the/O other/O heat/O labile/O ./O
No/O preferential/O VH/I //O VL/I -/O chains/O correlated/O with/O any/O of/O the/O 12/O different/O antigen/O reactivities/O ,/O even/O for/O mAbs/O with/O nearly/O identical/O cross/O -/O reactivities/O ./O
These/O results/O were/O compared/O with/O the/O estimates/O of/O penetration/O from/O steady/O -/O state/O calculations/O ,/O square/O root/O of/O time/O calculations/O ,/O and/O a/O biologically/O based/O mathematical/O model/O ./O
Based/O on/O this/O analysis/O ,/O we/O propose/O that/O the/O interactions/O of/O Sos/I with/O the/O switch/O 1/O and/O switch/O 2/O regions/O of/O Ras/I have/O distinct/O functional/O consequences/O :/O the/O interaction/O with/O switch/O 2/O mediates/O the/O anchoring/O of/O Ras/I to/O Sos/I ,/O whereas/O the/O interaction/O with/O switch/O 1/O leads/O to/O disruption/O of/O the/O nucleotide/O -/O binding/O site/O and/O GDP/O dissociation/O ./O
Thus/O ,/O the/O interaction/O of/O Tat/I with/O the/O components/O of/O this/O rel/I //O AP1/I cooperative/O complex/O seems/O to/O induce/O quantitative/O and/O qualitative/O alterations/O of/O this/O complex/O as/O activation/O progresses/O ,/O resulting/O in/O a/O decrease/O of/O IL/I -/I 2/I gene/I transcription/O ./O
SIT/I (/O SHP2/I -/I interacting/I transmembrane/I adaptor/I protein/I )/O is/O a/O recently/O identified/O transmembrane/O adaptor/O protein/O ,/O which/O is/O expressed/O in/O lymphocytes/O ./O
In/O this/O manuscript/O we/O demonstrate/O that/O two/O tandem/I Ets/I sites/I in/O the/O mouse/I GL/I alpha/I promoter/I bind/O the/O transcription/I factors/I Elf/I -/I 1/I and/O PU/I ./I 1/I ,/O and/O that/O the/O 3/O '/O site/O is/O essential/O for/O expression/O of/O a/O luciferase/I reporter/I gene/I driven/O by/O the/O GL/I alpha/I promoter/I ./O
ICA/O in/O the/O reference/O solution/O was/O characterised/O by/O LC/O and/O time/O -/O of/O -/O flight/O (/O TOF/O )/O MS/O and/O quantified/O by/O LC/O chemiluminescent/O nitrogen/O detection/O (/O LC/O -/O CLND/O )./O
These/O disorders/O include/O low/O -/O back/O pain/O ,/O saddle/O anesthesia/O ,/O bilateral/O sciatica/O ,/O then/O motor/O weakness/O of/O the/O lower/O extremities/O or/O chronic/O paraplegia/O and/O ,/O bladder/O dysfunction/O ./O
C/O ./O elegans/O embryogenesis/O begins/O with/O a/O stereotyped/O sequence/O of/O asymmetric/O cell/O divisions/O that/O are/O largely/O responsible/O for/O establishing/O the/O nematode/O body/O plan/O ./O
Additionally/O ,/O a/O CaCO3/O -/O CO2/O //O N2/O buffered/O solution/O was/O necessary/O to/O maintain/O a/O pH/O of/O 8/O ./O
Mss4/I also/O acts/O as/O a/O relatively/O inefficient/O guanine/I nucleotide/I exchange/I factor/I (/O GEF/I )./O
Effects/O of/O 3/O '/O terminus/O modifications/O on/O mRNA/O functional/O decay/O during/O in/O vitro/O protein/O synthesis/O ./O
Disciplinary/O action/O for/O DNA/O violation/O ./O
This/O is/O necessary/O if/O psychiatric/O diagnoses/O are/O ultimately/O going/O to/O be/O refined/O and/O validated/O against/O biological/O criteria/O ./O
We/O also/O demonstrate/O that/O the/O spo20/I (+)/I gene/I product/I is/O structurally/O homologous/O to/O Saccharomyces/I cerevisiae/I Sec14/I ,/O the/O major/O phosphatidylinositol/O transfer/O protein/O of/O budding/O yeast/O ./O
In/O addition/O ,/O another/O derivative/O of/O pCMVJS21/O (/O pCMVJS21DeltaGP/O )/O in/O which/O the/O gag/I ,/O pol/I (/O and/O orf/I -/I x/I )/O coding/O sequences/O were/O deleted/O also/O gave/O transformed/O foci/O ./O
It/O is/O shown/O that/O ,/O for/O any/O periodic/O input/O ,/O the/O map/O representing/O the/O relation/O between/O input/O phases/O at/O consecutive/O discharge/O times/O can/O be/O restricted/O to/O a/O piecewise/O continuous/O ,/O orientation/O preserving/O circle/O map/O ./O
Decreased/O serum/I ceruloplasmin/I and/O copper/O levels/O in/O cervical/O dystonia/O ./O
Northern/O blot/O analysis/O of/O RNAs/O from/O a/O number/O of/O mouse/O tissues/O reveals/O that/O Atp6i/I is/O expressed/O predominantly/O in/O osteoclasts/O ,/O and/O this/O predominant/O expression/O was/O confirmed/O by/O reverse/O -/O transcription/O polymerase/O chain/O reaction/O (/O RT/O -/O PCR/O )/O assay/O and/O immunohistochemical/O analysis/O ./O
Behavioural/O tests/O with/O 192/O specimen/O of/O the/O roman/O garden/O snail/O Helix/O pomatia/O L/O ./O were/O performed/O in/O order/O to/O clarify/O whether/O the/O thermopreferendum/O of/O this/O pulmonate/O is/O influenced/O not/O only/O by/O the/O temperature/O of/O the/O substratum/O but/O also/O by/O air/O temperature/O ./O
As/O well/O ,/O IFN/I -/I gamma/I -/O induced/O expression/O of/O IRF/I -/I 1/I and/O its/O binding/O to/O the/O IRF/I element/I is/O inhibited/O ./O
Baseline/O BMD/O values/O were/O significantly/O lower/O in/O the/O oligo/O -/O amenorrheic/O group/O than/O in/O the/O two/O others/O at/O the/O level/O of/O lumbar/O spine/O (/O anteroposterior/O view/O :/O 0/O ./O 941/O +/-/O 0/O ./O 039/O in/O oligo/O -/O amenorrheic/O vs/O 1/O ./O 077/O +/-/O 0/O ./O 029/O or/O 1/O ./O 051/O +/-/O 0/O ./O 017/O g/O x/O cm/O (-/O 2/O ),/O P/O ", "<*>"), ("<*>", "<*>")]
else:
padded = ["<*>", "<*>"]
padded.extend(sent)
if tags:
padded.append(("<$>", "<$>"))
else:
padded.append("<$>")
return padded
def calculateMetrics(actual, predicted):
"""
Returns the number of cases where prediction and actual NER
tags are the same, divided by the number of tags for the
sentence.
"""
pred_p = map(lambda x: "I" if x == "I" else "O", predicted)
cm = nltk.metrics.confusionmatrix.ConfusionMatrix(actual, pred_p)
keys = ["I", "O"]
metrics = np.matrix(np.zeros((2, 2)))
for x, y in [(x, y) for x in range(0, 2)
for y in range(0, 2)]:
try:
metrics[x, y] = cm[keys[x], keys[y]]
except KeyError:
pass
tp = metrics[0, 0]
tn = metrics[1, 1]
fp = metrics[0, 1]
fn = metrics[1, 0]
precision = 0 if (tp + fp) == 0 else tp / (tp + fp)
recall = 0 if (tp + fn) == 0 else tp / (tp + fn)
fmeasure = (0 if (precision + recall) == 0
else (2 * precision * recall) / (precision + recall))
accuracy = (tp + tn) / (tp + tn + fp + fn)
return (precision, recall, fmeasure, accuracy)
def writeResult(fout, hmm, words):
"""
Writes out the result in the required format.
"""
tags = hmm.best_path(words)
for word, tag in zip(words, tags)[2:-1]:
fout.write("%s %s\n" % (word, tag))
fout.write("\n")
def bigramToUnigram(bigrams):
"""
Convert a list of bigrams to the equivalent unigram list.
"""
unigrams = [bigrams[0][0]]
unigrams.extend([x[1] for x in bigrams])
return unigrams
def calculateBackoffTransCPD(tagsFD, transCFD, trans2CFD):
"""
Uses a backoff model to calculate a smoothed conditional
probability distribution on the training data.
"""
probDistDict = collections.defaultdict(nltk.DictionaryProbDist)
tags = tagsFD.keys()
conds = [x for x in itertools.permutations(tags, 2)]
for tag in tags:
conds.append((tag, tag))
for (t1, t2) in conds:
probDict = collections.defaultdict(float)
prob = 0
for t3 in tags:
trigramsFD = trans2CFD[(t1, t2)]
if trigramsFD.N() > 0 and trigramsFD.freq(t3) > 0:
prob = trigramsFD.freq(t3) / trigramsFD.N()
else:
bigramsFD = transCFD[t2]
if bigramsFD.N() > 0 and bigramsFD.freq(t3) > 0:
prob = bigramsFD.freq(t3) / bigramsFD.N()
else:
prob = tagsFD[t3] / tagsFD.N()
probDict[t3] = prob
probDistDict[(t1, t2)] = nltk.DictionaryProbDist(probDict)
return nltk.DictionaryConditionalProbDist(probDistDict)
class Accumulator:
"""
Convenience class to accumulate all the frequencies
into a set of data structures.
"""
def __init__(self, rareWords, replaceRare, useTrigrams):
self.rareWords = rareWords
self.replaceRare = replaceRare
self.useTrigrams = useTrigrams
self.words = set()
self.tags = set()
self.priorsFD = nltk.FreqDist()
self.transitionsCFD = nltk.ConditionalFreqDist()
self.outputsCFD = nltk.ConditionalFreqDist()
# additional data structures for trigram
self.transitions2CFD = nltk.ConditionalFreqDist()
self.tagsFD = nltk.FreqDist()
def addSentence(self, sent, norm_func):
# preprocess
unigrams = [(norm_func(word, self.rareWords, self.replaceRare), tag)
for (word, tag) in sent]
prevTag = None
prev2Tag = None
if self.useTrigrams:
# each state is represented by a tag bigram
bigrams = nltk.bigrams(unigrams)
for ((w1, t1), (w2, t2)) in bigrams:
self.words.add((w1, w2))
self.tags.add((t1, t2))
self.priorsFD.inc((t1, t2))
self.outputsCFD[(t1, t2)].inc((w1, w2))
if prevTag is not None:
self.transitionsCFD[prevTag].inc(t2)
if prev2Tag is not None:
self.transitions2CFD[prev2Tag].inc((t1, t2))
prevTag = t2
prev2Tag = (t1, t2)
self.tagsFD.inc(prevTag)
else:
# each state is represented by an tag unigram
for word, tag in unigrams:
self.words.add(word)
self.tags.add(tag)
self.priorsFD.inc(tag)
self.outputsCFD[tag].inc(word)
if prevTag is not None:
self.transitionsCFD[prevTag].inc(tag)
prevTag = tag
####################### train, validate, test ##################
def train(train_file,
rareWords, replaceRare, useTrigrams, trigramBackoff):
"""
Read the file and populate the various frequency and
conditional frequency distributions and build the HMM
off these data structures.
"""
acc = Accumulator(rareWords, replaceRare, useTrigrams)
reader = nltk.corpus.reader.TaggedCorpusReader(".", train_file)
for sent in reader.tagged_sents():
unigrams = pad(sent)
acc.addSentence(unigrams, normalizeRareWord)
if useTrigrams:
if trigramBackoff:
backoffCPD = calculateBackoffTransCPD(acc.tagsFD, acc.transitionsCFD,
acc.transitions2CFD)
return nltk.HiddenMarkovModelTagger(list(acc.words), list(acc.tags),
backoffCPD,
nltk.ConditionalProbDist(acc.outputsCFD, nltk.ELEProbDist),
nltk.ELEProbDist(acc.priorsFD))
else:
return nltk.HiddenMarkovModelTagger(list(acc.words), list(acc.tags),
nltk.ConditionalProbDist(acc.transitions2CFD, nltk.ELEProbDist,
len(acc.transitions2CFD.conditions())),
nltk.ConditionalProbDist(acc.outputsCFD, nltk.ELEProbDist),
nltk.ELEProbDist(acc.priorsFD))
else:
return nltk.HiddenMarkovModelTagger(list(acc.words), list(acc.tags),
nltk.ConditionalProbDist(acc.transitionsCFD, nltk.ELEProbDist,
len(acc.transitionsCFD.conditions())),
nltk.ConditionalProbDist(acc.outputsCFD, nltk.ELEProbDist),
nltk.ELEProbDist(acc.priorsFD))
def validate(hmm, validation_file, rareWords, replaceRare, useTrigrams):
"""
Tests the HMM against the validation file.
"""
precision = 0
recall = 0
fmeasure = 0
accuracy = 0
nSents = 0
reader = nltk.corpus.reader.TaggedCorpusReader(".", validation_file)
for sent in reader.tagged_sents():
sent = pad(sent)
words = [word for (word, tag) in sent]
tags = [tag for (word, tag) in sent]
normWords = map(lambda x: normalizeRareWord(
x, rareWords, replaceRare), words)
if useTrigrams:
# convert words to word bigrams
normWords = nltk.bigrams(normWords)
predictedTags = hmm.best_path(normWords)
if useTrigrams:
# convert tag bigrams back to unigrams
predictedTags = bigramToUnigram(predictedTags)
(p, r, f, a) = calculateMetrics(tags[2:-1], predictedTags[2:-1])
precision += p
recall += r
fmeasure += f
accuracy += a
nSents += 1
print("Accuracy=%f, Precision=%f, Recall=%f, F1-Measure=%f\n" %
(accuracy/nSents, precision/nSents, recall/nSents,
fmeasure/nSents))
def test(hmm, test_file, result_file, rareWords, replaceRare, useTrigrams):
"""
Tests the HMM against the test file (without tags) and writes
out the results to the result file.
"""
fin = open(test_file, 'rb')
fout = open(result_file, 'wb')
for line in fin:
line = line.strip()
words = pad([word for word in line.split(" ")], tags=False)
normWords = map(lambda x: normalizeRareWord(
x, rareWords, replaceRare), words)
if useTrigrams:
# convert words to word bigrams
normWords = nltk.bigrams(normWords)
tags = hmm.best_path(normWords)
if useTrigrams:
# convert tag bigrams back to unigrams
tags = bigramToUnigram(tags)
fout.write(" ".join(["/".join([word, tag])
for (word, tag) in (zip(words, tags))[2:-1]]) + "\n")
fin.close()
fout.close()
def main():
normalizeRare = False
replaceRare = False
useTrigrams = False
trigramBackoff = False
if len(sys.argv) > 1:
args = sys.argv[1:]
for arg in args:
k, v = arg.split("=")
if k == "normalize-rare":
normalizeRare = True if v.lower() == "true" else False
elif k == "replace-rare":
normalizeRare = True
replaceRare = True if v.lower() == "true" else False
elif k == "use-trigrams":
normalizeRare = True
replaceRare = True
useTrigrams = True if v.lower() == "true" else False
elif k == "trigram-backoff":
normalizeRare = True
replaceRare = True
useTrigrams = True
trigramBackoff = True if v.lower() == "true" else False
else:
continue
rareWords = set()
if normalizeRare:
rareWords = findRareWords("gene.train")
hmm = train("gene.train",
rareWords, replaceRare, useTrigrams, trigramBackoff)
validate(hmm, "gene.validate", rareWords, replaceRare, useTrigrams)
test(hmm, "gene.test", "gene.test.out",
rareWords, replaceRare, useTrigrams)
if __name__ == "__main__":
main()
================================================
FILE: src/hangman/game.py
================================================
# -*- coding: utf-8 -*-
import operator
from random import random
MAX_GUESSES_PER_GAME = 11
MAX_WORDS_IN_SUBSET = 25
########################### Preprocessing ############################
non_ascii_mappings = list([
('á', 'a'), ('å', 'a'), ('ä', 'a'), ('â', 'a'), ('Å', 'a'), ('Ã', 'a'),
('ç', 'c'), ('¢', 'c'),
('é', 'e'), ('é', 'e'), ('è', 'e'), ('ê', 'e'),
('í', 'i'),
('ñ', 'n'),
('ó', 'o'), ('ó', 'o'), ('ö', 'o'), ('ô', 'o'),
('ü', 'u'), ('û', 'u'),
('´', '\''), ('»', '"')
])
def ascii_fold(s):
for x in non_ascii_mappings:
s = s.replace(x[0], x[1])
return s
def preprocess(dictfile):
fwords = open(dictfile, 'rb')
wset = set()
for line in fwords:
word = line.strip().lower()
word = ascii_fold(word)
if word.endswith("'s"):
word = word[:-2]
word = word.replace(" ", "").replace("'", "").replace("\"", "")
wset.add(word)
fwords.close()
return list(wset)
############################# Proposer Side #############################
def select_secret_word(words):
widx = int(random() * len(words))
return words[widx]
def find_all_match_positions(secret_word, guess_char):
positions = []
curr_pos = 0
while curr_pos < len(secret_word):
curr_pos = secret_word.find(guess_char, curr_pos)
if curr_pos < 0:
break
positions.append(curr_pos)
curr_pos += 1
return positions
def update_guessed_word(guessed_word, matched_positions, guessed_char):
for pos in matched_positions:
guessed_word[pos] = guessed_char
def is_solved(guessed_word):
chars_remaining = len(filter(lambda x: x == '_', guessed_word))
return chars_remaining == 0
############################# Solver Side ###############################
letters = ["a", "b", "c", "d", "e", "f", "g", "h", "i", "j", "k", "l", "m",
"n", "o", "p", "q", "r", "s", "t", "u", "v", "w", "x", "y", "z"]
def most_frequent_char(words, previously_guessed):
cmap = {x:0 for x in letters}
for word in words:
cset = set()
for c in word:
if c not in previously_guessed:
cset.add(c)
for c in cset:
cmap[c] += 1
return sorted(map(lambda x: (x, cmap[x]), cmap.keys()),
key=operator.itemgetter(1), reverse=True)[0][0]
def best_guess(words, word_len, bad_guesses, good_guesses, guessed_word):
temp_words = filter(lambda x: len(x) == word_len, words)
if len(bad_guesses) > 0:
for bad_guess in bad_guesses:
temp_words = filter(lambda x: x.find(bad_guess) == -1, temp_words)
if len(good_guesses) > 0:
for good_guess in good_guesses:
temp_words = filter(lambda x: x.find(good_guess) > -1, temp_words)
previously_guessed = set(filter(lambda x: x != '_', guessed_word))
return temp_words, most_frequent_char(temp_words, previously_guessed)
def init_guess(wordlen):
initial_guess = []
for i in range(wordlen):
initial_guess.append("_")
return initial_guess
def match_words_against_template(words, guessed_word):
if len(words) > MAX_WORDS_IN_SUBSET:
return words
matched_words = []
for word in words:
word_chars = [c for c in word]
merged = zip(guessed_word, word_chars)
diff = len(filter(lambda x: x[0] != x[1],
filter(lambda x: x[0] != '_', merged)))
if diff == 0:
matched_words.append(word)
if len(matched_words) > 1:
break
return matched_words
def replace_guessed_word(guessed_word, matched_word):
matched_chars = [c for c in matched_word]
for i in range(len(matched_chars)):
guessed_word[i] = matched_chars[i]
################################# Game ###################################
def single_round(words, debug=False):
solver_wins = False
secret_word = select_secret_word(words)
if debug:
print "secret word:", secret_word
word_len = len(secret_word)
bad_guesses = set()
good_guesses = set()
guessed_word = init_guess(word_len)
for num_guesses in range(MAX_GUESSES_PER_GAME):
filtered_words, guess_char = best_guess(words, word_len, bad_guesses,
good_guesses, guessed_word)
if debug:
print "guessed char:", guess_char
matched_positions = find_all_match_positions(secret_word, guess_char)
if len(matched_positions) == 0:
bad_guesses.add(guess_char)
else:
good_guesses.add(guess_char)
update_guessed_word(guessed_word, matched_positions, guess_char)
matched_words = match_words_against_template(filtered_words, guessed_word)
if len(matched_words) == 1:
replace_guessed_word(guessed_word, matched_words[0])
if debug:
print "#", num_guesses, "guess:", " ".join(guessed_word)
if is_solved(guessed_word):
solver_wins = True
break
return len(secret_word), solver_wins, num_guesses
def multiple_rounds(words, num_games, report_file):
fdata = open(report_file, 'wb')
for i in range(num_games):
word_len, solver_wins, num_guesses = single_round(words, False)
fdata.write("%d,%d,%d\n" % (word_len, 1 if solver_wins else 0, num_guesses))
fdata.close()
################################# Main ###################################
words = preprocess("/usr/share/dict/words")
#single_round(words, True)
multiple_rounds(words, 10000, "hangman.csv")
================================================
FILE: src/hangman/gamestats.py
================================================
# -*- coding: utf-8 -*-
from __future__ import division
import pandas as pd
import matplotlib.pyplot as plt
df = pd.read_csv("hangman.csv", header=None,
names=["WORD_LEN", "SOLVER_WINS", "NUM_GUESSES"])
# wins vs losses
nloss = df[df["SOLVER_WINS"] == 0].count()["SOLVER_WINS"]
nwins = df[df["SOLVER_WINS"] == 1].count()["SOLVER_WINS"]
print "probability of winning=", nwins / (nwins + nloss)
print "probability of losing=", nloss / (nwins + nloss)
## probability of winning and losing for different word lengths
df2 = df.drop("NUM_GUESSES", 1)
df2_wins = df2[df2["SOLVER_WINS"] == 1].groupby("WORD_LEN").count().reset_index()
df2_losses = df2[df2["SOLVER_WINS"] == 0].groupby("WORD_LEN").count().reset_index()
df2_losses.rename(columns={"SOLVER_WINS": "SOLVER_LOSES"}, inplace=True)
df2_merged = df2_wins.merge(df2_losses, how="inner", on="WORD_LEN")
df2_merged.plot(kind="bar", stacked=True, x="WORD_LEN",
title="Win/Loss Counts by Word Length")
plt.show()
df2_merged["NUM_GAMES"] = df2_merged["SOLVER_WINS"] + df2_merged["SOLVER_LOSES"]
df2_merged["SOLVER_WINS"] = df2_merged["SOLVER_WINS"] / df2_merged["NUM_GAMES"]
df2_merged["SOLVER_LOSES"] = df2_merged["SOLVER_LOSES"] / df2_merged["NUM_GAMES"]
df2_merged.drop("NUM_GAMES", axis=1, inplace=True)
df2_merged.plot(kind="bar", stacked=True, x="WORD_LEN",
title="Win/Loss Probabilities by Word Length")
plt.show()
# how number of guesses to win varies with word length (winning games only)
df3 = df[df["SOLVER_WINS"] == 1]
df3.drop("SOLVER_WINS", 1)
df3_grouped = df3.drop("SOLVER_WINS", 1).groupby("WORD_LEN").mean().reset_index()
df3_grouped.plot(kind="bar", x="WORD_LEN",
title="Avg Guesses for Different Word Lengths")
plt.show()
================================================
FILE: src/langmodel/med_lang_model.py
================================================
from __future__ import division
import math
import os.path
import cPickle
import glob
import nltk
from nltk.corpus.reader import XMLCorpusReader
class LangModel:
def __init__(self, order, alpha, sentences):
self.order = order
self.alpha = alpha
if order > 1:
self.backoff = LangModel(order - 1, alpha, sentences)
self.lexicon = None
else:
self.backoff = None
self.n = 0
self.ngramFD = nltk.FreqDist()
lexicon = set()
for sentence in sentences:
words = nltk.word_tokenize(sentence)
wordNGrams = nltk.ngrams(words, order)
for wordNGram in wordNGrams:
self.ngramFD.inc(wordNGram)
if order == 1:
lexicon.add(wordNGram)
self.n += 1
self.v = len(lexicon)
def logprob(self, ngram):
return math.log(self.prob(ngram))
def prob(self, ngram):
if self.backoff != None:
freq = self.ngramFD[ngram]
backoffFreq = self.backoff.ngramFD[ngram[1:]]
if freq == 0:
return self.alpha * self.backoff.prob(ngram[1:])
else:
return freq / backoffFreq
else:
# laplace smoothing to handle unknown unigrams
return ((self.ngramFD[ngram] + 1) / (self.n + self.v))
def train():
if os.path.isfile("lm.bin"):
return
files = glob.glob("data/*.xml")
sentences = []
i = 0
for file in files:
if i > 0 and i % 500 == 0:
print("%d/%d files loaded, #-sentences: %d" %
(i, len(files), len(sentences)))
dir, file = file.split("/")
reader = XMLCorpusReader(dir, file)
sentences.extend(nltk.sent_tokenize(" ".join(reader.words())))
i += 1
lm = LangModel(3, 0.4, sentences)
cPickle.dump(lm, open("lm.bin", "wb"))
def test():
lm1 = cPickle.load(open("lm.bin", 'rb'))
testFile = open("sentences.test", 'rb')
for line in testFile:
sentence = line.strip()
print "SENTENCE:", sentence,
words = nltk.word_tokenize(sentence)
wordTrigrams = nltk.trigrams(words)
slogprob = 0
for wordTrigram in wordTrigrams:
logprob = lm1.logprob(wordTrigram)
slogprob += logprob
print "(", slogprob / len(words), ")"
def main():
train()
test()
if __name__ == "__main__":
main()
================================================
FILE: src/langmodel/old_med_lang_model.py
================================================
from __future__ import division
import glob
import nltk
from nltk.corpus.reader import XMLCorpusReader
from nltk.model.ngram import NgramModel
from nltk.probability import LidstoneProbDist
import cPickle
def train():
# parse XML and load up words
print("Loading words from XML files...")
sentences = []
files = glob.glob("data/*.xml")
i = 0
for file in files:
if i > 0 and i % 500 == 0:
print("%d/%d files loaded, #-sentences: %d" %
(i, len(files), len(sentences)))
break
dir, file = file.split("/")
reader = XMLCorpusReader(dir, file)
sentences.extend(nltk.sent_tokenize(" ".join(reader.words())))
i += 1
words = []
for sentence in sentences:
words.append(nltk.word_tokenize(sentence))
# build a trigram Language Model (using default Good-Turing
# smoothing) with the words array
print("Building language model...")
est = lambda fdist, bins: LidstoneProbDist(fdist, 0.2)
langModel = NgramModel(3, words, estimator=est)
# langModel = NgramModel(3, words)
# cPickle.dump(langModel, open("lm.bin", 'wb'))
return langModel
def test(langModel):
testData = open("sentences.test", 'rb')
for line in testData:
sentence = line.strip()
print "SENTENCE:", sentence,
words = nltk.word_tokenize(sentence)
trigrams = nltk.trigrams(words)
slogprob = 0
for trigram in trigrams:
word = trigram[2]
context = list(trigrams[:-1])
slogprob += langModel.logprob(word, context)
print "(", slogprob, ")"
testData.close()
def main():
langModel = train()
test(langModel)
if __name__ == "__main__":
main()
================================================
FILE: src/langmodel/sentences.test
================================================
In biology, immunity is the state of having sufficient biological defences to avoid infection, disease, or other unwanted biological invasion.
Naturally acquired immunity occurs through contact with a disease causing agent, when the contact was not deliberate, whereas artificially acquired immunity develops only through deliberate actions such as vaccination.
Immunity from prosecution occurs when a prosecutor grants immunity, usually to a witness in exchange for testimony or production of other evidence.
Transactional immunity (colloquially known as "blanket" or "total" immunity) completely protects the witness from future prosecution for crimes related to his or her testimony.
Hearing loss is being partly or totally unable to hear sound in one or both ears.
Conductive hearing loss (CHL) occurs because of a mechanical problem in the outer or middle ear.
Sensorineural hearing loss (SNHL) occurs when the tiny hair cells (nerve endings) that detect sound in the ear are injured, diseased, do not work correctly, or have died.
This type of hearing loss often cannot be reversed.
In law, a hearing is a proceeding before a court or other decision-making body or officer, such as a government agency.
Within some criminal justice systems, a preliminary hearing (evidentiary hearing) is a proceeding, after a criminal complaint has been filed by the prosecutor, to determine whether there is enough evidence to require a trial.
================================================
FILE: src/medorleg/README.md
================================================
##INTRODUCTION
The motivation for this project is to automatically determine if a sentence is from a medical or a legal genre. This is needed to support a medical litigation decision support system which allows a user to search for documents using concepts rather than terms[1]. Concepts are medical and legal named entities, such as diseases, drugs, organizations, jurisdictions, etc. These entities are extracted during document indexing by looking up words and phrases in each sentence against domain specific taxonomies for each genre. Documents are then annotated with the entity IDs, where they can be discovered during concept search. Unfortunately, this can often produce ambiguous concepts that can mean very different things in the two genres - for example, hearing, period and immunity. This creates a bad search experience.
To address this, we build a classifier that can classify an incoming sentence into one of the two genres. This classifier acts as a preprocessor that will route the sentence into one of two knowledge bases for entity recognition and annotation.
##METHODS
We build two interpolated trigram language models[2], one for each genre. An interpolated trigram language model approximates the probability of a specific trigram as a linear combination of the frequency of the trigram and the associated bigram and unigram. The interpolated score for each trigram (w1,w2,w3) is given by:
p(w1,w2,w3|c) = α * p(w1,w2,w3) + β * p(w2,w3) + γ * p(w3) ...(1)
where:
p(w1,w2,w3|c) = C(w1,w2,w3) / Number of trigrams in corpus
p(w1,w2,w3) = C(w1,w2,w3) / C(w2,w3)
p(w2,w3) = C(w2,w3) / C(w3)
p(w3) = (C(w3) + 1) / (N + V)
N = number of terms in corpus
V = number of vocabulary terms
The unigram probability is smoothed using Laplace smoothing so unseen unigrams in the test set don't result in a zero score for the sentence. The parameters α, β and γ are learned from the training data using a simple linear regression algorithm.
The coefficients of the linear model should also satisfy this constraint:
α + β + γ = 1 ...(2)
Using the models for the two genres as described above, the probability for an unseen sentence is calculated for each genre, as the joint probability (product) of each of its trigrams. The sentence is classified into the genre which is more probable according to the model.
##ANALYSIS
The model described above was generated and tested as follows:
1. Our training set consists of a medical corpus (about 10,000 files from the Gale Medical Encyclopedia[3]), and a legal corpus (about 4,000 files from the Australian Case Law Dataset[4]). The first step (preprocess.py[7]) is to parse the XML files in each corpus into a single flat file of sentences. Each sentence is tagged with a source (M or L). We end up with 950,887 medical sentences and 837,393 legal sentences.
2. We randomly choose 1,000 sentences from each category (testset_splitter.py[7]) to use as a test set for evaluating our classifier.
3. Use a MapReduce job (ngram_counting_job.py[7]) using mrjob[5] and NLTK to compute the counts for trigrams, bigrams and unigrams for each sentence. This gives us 3,740,646 medical and 5,092,913 legal count records.
4. Populate a SQLite3 database with the aggregated counts (db_loader.py[7]). We use SQLite3 as a persistent lookup table for doing probability calculations (regression_data.py[7]) for each trigram, ie finding the p(w) values in equation (1) above. The output of this step is a set of X (variable) and y (outcome) values for the trigrams in each genre.
5. Train a Linear Regression model for each genre (model_params.py[7]). The coefficients of the Linear model correspond to the unnormalized values of α, β, and γ in equation (2). We normalize both models by dividing the coefficients and the intercept by the sum of the coefficients.
6. Convert each test sentences into trigrams and compute the joint probability of the trigrams against each model (eval_model.py[7]), and report on overall accuracy of the model.
##RESULTS
The overall accuracy for the classifier was 92.7%. The legal model performed better, correctly classifying 997 of 1,000 legal documents, as opposed to the medical model, which correctly classfied only 857 of 1,000 medical documents. The confusion matrix is shown below:
M L <-- classified as
857 143 | M
3 997 | L
##CONCLUSION
An accuracy of 92.7% is adequate for our purposes, so we can consider putting this model into production. However, its performance can probably be improved through the use of more sophisticated regression algorithms.
##REFERENCES
1. Concept Search [http://en.wikipedia.org/wiki/Concept_Search, downloaded May 30, 2013].
2. Interpolated Language Models from Introduction to Information Retrieval Chapter 12: Language Models for Information Retrieval, by Manning, Schultz, et al [http://nlp.stanford.edu/IR-book/pdf/12lmodel.pdf, downloaded May 30, 2013].
3. Gale Encyclopedia of Medicine, 4/Ed (EBook Edition) [http://www.gale.cengage.com/servlet/ItemDetailServlet?region=9&imprint=000&cf=e&titleCode=GEME&type=4&id=259611, downloaded May 31, 2013].
4. UCI Machine Learning Repository Legal Case Reports Dataset [http://archive.ics.uci.edu/ml/datasets/Legal+Case+Reports, downloaded May 25, 2013].
5. MRJob Tutorial [http://www.brianweidenbaum.com/mapreduce-python-mrjob-tutorial/, downloaded May 31, 2013].
6. R-Squared Coefficient of Determination [http://en.wikipedia.org/wiki/Coefficient_of_determination, downloaded June 3, 2013].
7. Code for the analysis [https://github.com/sujitpal/nltk-examples/tree/master/src/medorleg, uploaded June 3, 2013].
8. Scikit-learn: Machine Learning in Python, Pedregosa et al., JMLR 12, pp. 2825-2830, 2011.
================================================
FILE: src/medorleg/db_loader.py
================================================
import sqlite3 as sql
def is_empty(conn):
cur = conn.cursor()
cur.execute("select name from sqlite_master where type='table'")
rows = cur.fetchall()
return len(rows) == 0
def create_tables(conn):
if not is_empty(conn):
return
cur = conn.cursor()
cur.executescript("""
create table m3 (w1 text, w2 text, w3 text, freq integer);
create table m2 (w2 text, w3 text, freq integer);
create table m1 (w3 text, freq integer);
create table l3 (w1 text, w2 text, w3 text, freq integer);
create table l2 (w2 text, w3 text, freq integer);
create table l1 (w3 text, freq integer);
""")
conn.commit()
def gram_to_list(gram):
return [x[1:-1] for x in gram[1:-1].split(", ")]
def populate_tables(conn, infn, t3n, t2n, t1n):
cur = conn.cursor()
infile = open(infn, 'rb')
i = 0
for line in infile:
if i % 1000 == 0:
print "Processing %s, line: %d" % (infn, i)
gram, count = line.strip().split("\t")
gramlist = gram_to_list(gram)
if len(gramlist) == 3:
cur.execute("insert into %s(w1,w2,w3,freq)values(?,?,?,?)" % (t3n),
(gramlist[0], gramlist[1], gramlist[2], int(count)))
elif len(gramlist) == 2:
cur.execute("insert into %s(w2,w3,freq)values(?,?,?)" % (t2n),
(gramlist[0], gramlist[1], int(count)))
else:
cur.execute("insert into %s(w3,freq)values(?,?)" % (t1n),
(gramlist[0], int(count)))
i += 1
infile.close()
conn.commit()
def build_indexes(conn):
print "Building indexes..."
cur = conn.cursor()
cur.executescript("""
create unique index ix_m3 on m3(w1,w2,w3);
create unique index ix_m2 on m2(w2,w3);
create unique index ix_m1 on m1(w3);
create unique index ix_l3 on l3(w1,w2,w3);
create unique index ix_l2 on l2(w2,w3);
create unique index ix_l1 on l1(w3);
""")
conn.commit()
def main():
conn = sql.connect("data/db/ngram_freqs.db")
create_tables(conn)
populate_tables(conn, "data/counts/medical_count.txt", "m3", "m2", "m1")
populate_tables(conn, "data/counts/legal_count.txt", "l3", "l2", "l1")
build_indexes(conn)
conn.close()
if __name__ == "__main__":
main()
================================================
FILE: src/medorleg/eval_model.py
================================================
from __future__ import division
import math
import sqlite3 as sql
import cPickle as pickle
import nltk
import numpy as np
import string
def normalize_numeric(x):
xc = x.translate(string.maketrans("", ""), string.punctuation)
return "_NNN_" if xc.isdigit() else x
def normalize_stopword(x, stopwords):
return "_SSS_" if str(x) in stopwords else x
def get_trigrams(sentence, stopwords, porter):
words = nltk.word_tokenize(sentence)
words = [word.lower() for word in words]
words = [normalize_numeric(word) for word in words]
words = [normalize_stopword(word, stopwords) for word in words]
words = [porter.stem(word) for word in words]
return nltk.trigrams(words)
def get_base_counts(conn, morl):
cur = conn.cursor()
cur.execute("select count(*), sum(freq) from %s1" % (morl))
v, n = cur.fetchall()[0]
return n, v
def load_model_coeffs(model):
norm = np.sum(model.coef_)
return np.array([model.coef_[0] / norm,
model.coef_[1] / norm,
model.coef_[2] / norm,
model.intercept_ / norm])
def calc_prob(trigrams, conn, coeffs, morl, n, v):
joint_log_prob = 0.0
cur = conn.cursor()
for trigram in trigrams:
cur.execute("select freq from %s3 where w1 = ? and w2 = ? and w3 = ?"
% (morl), trigram)
rows = cur.fetchall()
freq3 = 0 if len(rows) == 0 else rows[0][0]
cur.execute("select freq from %s2 where w2 = ? and w3 = ?" %
(morl), trigram[1:])
rows = cur.fetchall()
freq2 = 0 if len(rows) == 0 else rows[0][0]
cur.execute("select freq from %s1 where w3 = ?" % (morl), trigram[2:])
rows = cur.fetchall()
freq1 = 0 if len(rows) == 0 else rows[0][0]
freqs = np.array([
0 if freq3 == 0 else freq3 / freq2,
0 if freq2 == 0 else freq2 / freq1,
0 if freq1 == 0 else (freq1 + 1) / (n + v),
1.0])
joint_log_prob += math.log(1 + np.dot(coeffs, freqs))
return joint_log_prob
def eval_model(medmodelfn, legmodelfn, testfn, stopwords, porter, conn):
pos = {"M": 0, "L": 1}
stats = np.zeros((2, 2))
med_params = load_model_coeffs(pickle.load(open(medmodelfn, 'rb')))
leg_params = load_model_coeffs(pickle.load(open(legmodelfn, 'rb')))
mn, mv = get_base_counts(conn, "m")
ln, lv = get_base_counts(conn, "l")
testfile = open(testfn, 'rb')
i = 0
for line in testfile:
if i % 100 == 0:
print "Tested %d/1000 test cases..." % (i)
i += 1
cols = line.strip().split("|")
trigrams = get_trigrams(cols[1], stopwords, porter)
med_prob = calc_prob(trigrams, conn, med_params, "m", mn, mv)
leg_prob = calc_prob(trigrams, conn, leg_params, "l", ln, lv)
ytruth = cols[0]
ypred = "M" if med_prob > leg_prob else "L"
print "...", i, ytruth, ypred
stats[pos[ytruth], pos[ypred]] += 1
return stats
def calc_acc(stats):
return np.sum(np.diag(stats)) / np.sum(stats)
def main():
stopwords = nltk.corpus.stopwords.words("english")
porter = nltk.PorterStemmer()
conn = sql.connect("data/db/ngram_freqs.db")
med_stats = eval_model("data/regdata/medical.pkl",
"data/regdata/legal.pkl", "data/sentences/medical_test.txt",
stopwords, porter, conn)
print "confusion matrix (med), acc=", calc_acc(med_stats)
print med_stats
leg_stats = eval_model("data/regdata/medical.pkl",
"data/regdata/legal.pkl", "data/sentences/legal_test.txt",
stopwords, porter, conn)
print "confusion matrix (leg), acc=", calc_acc(leg_stats)
print leg_stats
merged_stats = med_stats + leg_stats
print "confusion matrix (merged), acc=", calc_acc(merged_stats)
print merged_stats
conn.close()
if __name__ == "__main__":
main()
================================================
FILE: src/medorleg/model_params.py
================================================
from __future__ import division
import cPickle as pickle
import numpy as np
from sklearn.linear_model import LinearRegression
from sklearn.metrics import r2_score
def train(prefix):
X = np.exp(np.loadtxt(prefix + "_X.txt"))
y = np.exp(np.loadtxt(prefix + "_y.txt"))
model = LinearRegression(fit_intercept=True)
model.fit(X, y)
ypred = model.predict(X)
print prefix, model.coef_, model.intercept_, r2_score(y, ypred)
pickle.dump(model, open(prefix + ".pkl", 'wb'))
def main():
train("data/regdata/medical")
train("data/regdata/legal")
if __name__ == "__main__":
main()
================================================
FILE: src/medorleg/ngram_counting_job.py
================================================
from __future__ import division
from mrjob.job import MRJob
import nltk
import string
class NGramCountingJob(MRJob):
def mapper_init(self):
# self.stopwords = nltk.corpus.stopwords.words("english")
self.stopwords = set(['i', 'me', 'my', 'myself', 'we',
'our', 'ours', 'ourselves', 'you', 'your', 'yours',
'yourself', 'yourselves', 'he', 'him', 'his', 'himself',
'she', 'her', 'hers', 'herself', 'it', 'its', 'itself',
'they', 'them', 'their', 'theirs', 'themselves', 'what',
'which', 'who', 'whom', 'this', 'that', 'these', 'those',
'am', 'is', 'are', 'was', 'were', 'be', 'been', 'being',
'have', 'has', 'had', 'having', 'do', 'does', 'did',
'doing', 'a', 'an', 'the', 'and', 'but', 'if', 'or',
'because', 'as', 'until', 'while', 'of', 'at', 'by',
'for', 'with', 'about', 'against', 'between', 'into',
'through', 'during', 'before', 'after', 'above', 'below',
'to', 'from', 'up', 'down', 'in', 'out', 'on', 'off',
'over', 'under', 'again', 'further', 'then', 'once',
'here', 'there', 'when', 'where', 'why', 'how', 'all',
'any', 'both', 'each', 'few', 'more', 'most', 'other',
'some', 'such', 'no', 'nor', 'not', 'only', 'own', 'same',
'so', 'than', 'too', 'very', 's', 't', 'can', 'will',
'just', 'don', 'should', 'now'])
self.porter = nltk.PorterStemmer()
def mapper(self, key, value):
def normalize_numeric(x):
xc = x.translate(string.maketrans("", ""), string.punctuation)
return "_NNN_" if xc.isdigit() else x
def normalize_stopword(x):
return "_SSS_" if str(x) in self.stopwords else x
cols = value.split("|")
words = nltk.word_tokenize(cols[1])
# normalize number and stopwords and stem remaining words
words = [word.lower() for word in words]
words = [normalize_numeric(word) for word in words]
words = [normalize_stopword(word) for word in words]
words = [self.porter.stem(word) for word in words]
trigrams = nltk.trigrams(words)
for trigram in trigrams:
yield (trigram, 1)
bigram = trigram[1:]
yield (bigram, 1)
unigram = bigram[1:]
yield (unigram, 1)
def reducer(self, key, values):
yield (key, sum([value for value in values]))
if __name__ == "__main__":
NGramCountingJob.run()
================================================
FILE: src/medorleg/preprocess.py
================================================
# -*- coding: utf-8 -*-
from __future__ import division
import glob
import nltk
import re
from xml.dom.minidom import Node
from xml.dom.minidom import parseString
def medical_plaintext(fn):
print "processing", fn
if not (fn.startswith("data/medical/eph_") or
fn.startswith("data/medical/gemd_") or
fn.startswith("data/medical/gesu_") or
fn.startswith("data/medical/gea2_") or
fn.startswith("data/medical/gem_") or
fn.startswith("data/medical/gech_") or
fn.startswith("data/medical/geca_") or
fn.startswith("data/medical/gecd_") or
fn.startswith("data/medical/gegd_") or
fn.startswith("data/medical/gend_") or
fn.startswith("data/medical/gec_") or
fn.startswith("data/medical/genh_") or
fn.startswith("data/medical/nwaz_")):
return ""
file = open(fn, 'rb')
data = file.read()
file.close()
# remove gale: namespace from attributes
data = re.sub("gale:", "", data)
dom = parseString(data)
text = ""
paragraphs = dom.getElementsByTagName("p")
for paragraph in paragraphs:
xml = paragraph.toxml()
xml = re.sub("\n", " ", xml)
xml = re.sub("<.*?>", "", xml)
text = text + " " + xml
text = re.sub("\\s+", " ", text)
text = text.strip()
text = text.encode("ascii", "ignore")
return text
def legal_plaintext(fn):
print "processing", fn
file = open(fn, 'rb')
data = file.read()
data = re.sub("é", "e", data)
data = re.sub("á", "a", data)
data = re.sub("ý", "y", data)
data = re.sub(" ", " ", data)
data = re.sub("&tm;", "(TM)", data)
data = re.sub("®", "(R)", data)
data = re.sub("à", "a", data)
data = re.sub("è", "e", data)
data = re.sub("ì", "i", data)
data = re.sub("ê", "e", data)
data = re.sub("ô", "o", data)
data = re.sub("î", "i", data)
data = re.sub("ç", "c", data)
data = re.sub("&", "and", data)
data = re.sub("ä", "a", data)
data = re.sub("ß", "ss", data)
data = re.sub("æ", "e", data)
data = re.sub("ï", "i", data)
data = re.sub("ë", "e", data)
data = re.sub("ö", "o", data)
data = re.sub("ü", "u", data)
data = re.sub("â", "a", data)
data = re.sub("ø", "o", data)
data = re.sub("ñ", "n", data)
data = re.sub("É", "E", data)
data = re.sub("Å", "A", data)
data = re.sub("Ö", "O", data)
data = re.sub("", "e", data)
# fix "id=xxx" pattern, causes XML parsing to fail
data = re.sub("\"id=", "id=\"", data)
file.close()
text = ""
dom = parseString(data)
sentencesEl = dom.getElementsByTagName("sentences")[0]
for sentenceEl in sentencesEl.childNodes:
if sentenceEl.nodeType == Node.ELEMENT_NODE:
stext = sentenceEl.firstChild.data
if len(stext.strip()) == 0:
continue
text = text + " " + re.sub("\n", " ", stext)
text = re.sub("\\s+", " ", text)
text = text.strip()
text = text.encode("ascii", "ignore")
return text
def convert_to_plaintext(dir, ofn, category, func):
ofile = open(ofn, 'wb')
files = glob.glob("/".join([dir, "*.xml"]))
for file in files:
text = func(file)
if len(text.strip()) > 0:
for sentence in nltk.sent_tokenize(text):
ofile.write("%s\n" % ("|".join([category, sentence])))
ofile.close()
def main():
convert_to_plaintext("data/medical", "medical.txt", "M", medical_plaintext)
convert_to_plaintext("data/legal", "legal.txt", "L", legal_plaintext)
if __name__ == "__main__":
main()
================================================
FILE: src/medorleg/regression_data.py
================================================
from __future__ import division
import math
import sqlite3 as sql
def get_base_counts(conn, morl):
cur = conn.cursor()
cur.execute("select count(*), sum(freq) from %s1" % (morl))
v, n = cur.fetchall()[0]
return n, v
def gram_to_list(gram):
return [x[1:-1] for x in gram[1:-1].split(", ")]
def build_regdata(conn, morl, infn, outX, outY):
cur = conn.cursor()
infile = open(infn, 'rb')
xfile = open(outX, 'wb')
yfile = open(outY, 'wb')
n, v = get_base_counts(conn, morl)
i = 0
for line in infile:
gram, freq = line.strip().split("\t")
gramlist = gram_to_list(gram)
if len(gramlist) == 3:
cur.execute("select freq from %s3 where w1 = ? and w2 = ? and w3 = ?"
% (morl), gramlist)
rows = cur.fetchall()
freq3 = 0 if len(rows) == 0 else rows[0][0]
cur.execute("select freq from %s2 where w2 = ? and w3 = ?" %
(morl), gramlist[1:])
rows = cur.fetchall()
freq2 = 0 if len(rows) == 0 else rows[0][0]
cur.execute("select freq from %s1 where w3 = ?" % (morl), gramlist[2:])
rows = cur.fetchall()
freq1 = 0 if len(rows) == 0 else rows[0][0]
y = math.log(freq3) - math.log(n)
x0 = math.log(freq3) - math.log(freq2)
x1 = math.log(freq2) - math.log(freq1)
x2 = math.log(freq1 + 1) / math.log(n + v)
print morl, x0, x1, x2, y
xfile.write("%s %s %s\n" % (x0, x1, x2))
yfile.write("%s\n" % (y))
infile.close()
xfile.close()
yfile.close()
def main():
conn = sql.connect("data/db/ngram_freqs.db")
build_regdata(conn, "m", "data/counts/medical_count.txt",
"data/regdata/medical_X.txt", "data/regdata/medical_y.txt")
build_regdata(conn, "l", "data/counts/legal_count.txt",
"data/regdata/legal_X.txt", "data/regdata/legal_y.txt")
conn.close()
if __name__ == "__main__":
main()
================================================
FILE: src/medorleg/testset_splitter.py
================================================
import numpy as np
def main():
filelines = {
"data/sentences/medical.txt": 950887,
"data/sentences/legal.txt": 837393
}
for file, lines in filelines.items():
test_ids = sorted([int(lines * x) for x in np.random.random((1000,))])
fn = file.split(".")[0]
input_file = open(file, 'rb')
train_file = open(fn + "_train.txt", 'wb')
test_file = open(fn + "_test.txt", 'wb')
curr_line = 0
curr_pos = 0
for line in input_file:
if curr_pos < 1000 and curr_line == test_ids[curr_pos]:
test_file.write(line)
curr_pos += 1
else:
train_file.write(line)
curr_line += 1
input_file.close()
train_file.close()
test_file.close()
if __name__ == "__main__":
main()
================================================
FILE: src/medorleg2/arffwriter.py
================================================
import os.path
import numpy as np
import operator
def qq(s):
return "'" + s + "'"
def save_arff(X, y, vocab, fname):
aout = open(fname, 'wb')
# header
aout.write("@relation %s\n\n" %
(os.path.basename(fname).split(".")[0]))
# input variables
for term in vocab:
aout.write("@attribute \"%s\" numeric\n" % (term))
# target variable
aout.write("@attribute target_var {%s}\n" %
(",".join([qq(str(int(e))) for e in list(np.unique(y))])))
# data
aout.write("\n@data\n")
for row in range(0, X.shape[0]):
rdata = X.getrow(row)
idps = sorted(zip(rdata.indices, rdata.data), key=operator.itemgetter(0))
if len(idps) > 0:
aout.write("{%s,%d '%d'}\n" % (
",".join([" ".join([str(idx), str(dat)]) for (idx,dat) in idps]),
X.shape[1], int(y[row])))
aout.close()
================================================
FILE: src/medorleg2/arffwriter_test.py
================================================
import sys
import operator
from arffwriter import save_arff
import datetime
import numpy as np
from sklearn.cross_validation import train_test_split
from sklearn.feature_extraction.text import CountVectorizer
from sklearn.feature_extraction.text import TfidfTransformer
from sklearn.pipeline import Pipeline
def load_xy(xfile, yfile):
pipeline = Pipeline([
("count", CountVectorizer(stop_words='english', min_df=0.0,
binary=False)),
("tfidf", TfidfTransformer(norm="l2"))
])
xin = open(xfile, 'rb')
X = pipeline.fit_transform(xin)
xin.close()
yin = open(yfile, 'rb')
y = np.loadtxt(yin)
yin.close()
vocab_map = pipeline.steps[0][1].vocabulary_
vocab = [x[0] for x in sorted([(x, vocab_map[x])
for x in vocab_map],
key=operator.itemgetter(1))]
return X, y, vocab
def print_timestamp(message):
print message, datetime.datetime.now()
def main():
if len(sys.argv) != 5:
print "Usage: arffwriter_test Xfile yfile trainARFF testARFF"
sys.exit(-1)
print_timestamp("started:")
X, y, vocab = load_xy(sys.argv[1], sys.argv[2])
Xtrain, Xtest, ytrain, ytest = train_test_split(X, y,
test_size=0.1, random_state=42)
save_arff(Xtrain, ytrain, vocab, sys.argv[3])
save_arff(Xtest, ytest, vocab, sys.argv[4])
print_timestamp("finished:")
if __name__ == "__main__":
main()
================================================
FILE: src/medorleg2/classify.py
================================================
#! /usr/bin/python
from __future__ import division
import sys
import cPickle as pickle
import datetime
import nltk
import numpy as np
from sklearn.cross_validation import KFold
from sklearn.cross_validation import train_test_split
from sklearn.feature_extraction.text import CountVectorizer
from sklearn.feature_extraction.text import TfidfTransformer
from sklearn.metrics import accuracy_score
from sklearn.metrics import classification_report
from sklearn.metrics import confusion_matrix
from sklearn.pipeline import Pipeline
from sklearn.svm import LinearSVC
# total number of sentences (combined)
NTOTAL = 1788280
def calc_ngrams(line):
""" Converts line into a list of trigram tokens """
words = nltk.word_tokenize(line.lower())
word_str = " ".join(words)
bigrams = nltk.bigrams(words)
bigram_str = " ".join(["0".join(bigram) for bigram in bigrams])
trigrams = nltk.trigrams(words)
trigram_str = " ".join(["0".join(trigram) for trigram in trigrams])
return " ".join([word_str, bigram_str, trigram_str])
def generate_xy(texts, labels):
ftext = open(texts, 'rb')
pipeline = Pipeline([
("count", CountVectorizer(stop_words='english', min_df=0.0,
# max_features=10000,
binary=False)),
("tfidf", TfidfTransformer(norm="l2"))
])
# X = pipeline.fit_transform(map(lambda line: calc_ngrams(line), ftext))
X = pipeline.fit_transform(ftext)
ftext.close()
flabel = open(labels, 'rb')
y = np.loadtxt(flabel)
flabel.close()
return X, y
def crossvalidate_model(X, y, nfolds):
kfold = KFold(X.shape[0], n_folds=nfolds)
avg_accuracy = 0
for train, test in kfold:
Xtrain, Xtest, ytrain, ytest = X[train], X[test], y[train], y[test]
clf = LinearSVC()
clf.fit(Xtrain, ytrain)
ypred = clf.predict(Xtest)
accuracy = accuracy_score(ytest, ypred)
print "...accuracy = ", accuracy
avg_accuracy += accuracy
print "Average Accuracy: ", (avg_accuracy / nfolds)
def train_model(X, y, binmodel):
model = LinearSVC()
model.fit(X, y)
# reports
ypred = model.predict(X)
print "Confusion Matrix (Train):"
print confusion_matrix(y, ypred)
print "Classification Report (Train)"
print classification_report(y, ypred)
pickle.dump(model, open(binmodel, 'wb'))
def test_model(X, y, binmodel):
model = pickle.load(open(binmodel, 'rb'))
if y is not None:
# reports
ypred = model.predict(X)
print "Confusion Matrix (Test)"
print confusion_matrix(y, ypred)
print "Classification Report (Test)"
print classification_report(y, ypred)
def print_timestamp(message):
print message, datetime.datetime.now()
def usage():
print "Usage: python classify.py [xval|test|train]"
sys.exit(-1)
def main():
if len(sys.argv) != 2:
usage()
print_timestamp("started:")
X, y = generate_xy("data/sentences.txt", "data/labels.txt")
if sys.argv[1] == "xval":
crossvalidate_model(X, y, 10)
elif sys.argv[1] == "run":
Xtrain, Xtest, ytrain, ytest = train_test_split(X, y,
test_size=0.1, random_state=42)
train_model(Xtrain, ytrain, "data/model.bin")
test_model(Xtest, ytest, "data/model.bin")
else:
usage()
print_timestamp("finished:")
if __name__ == "__main__":
main()
================================================
FILE: src/medorleg2/preprocess.py
================================================
# -*- coding: utf-8 -*-
# Code to convert from XML format to a file of sentences for
# each genre, one sentence per line.
from __future__ import division
import glob
import nltk
import re
import unicodedata
from xml.dom.minidom import Node
from xml.dom.minidom import parseString
def medical_plaintext(fn):
print "processing", fn
if not (fn.startswith("data/medical/eph_") or
fn.startswith("data/medical/gemd_") or
fn.startswith("data/medical/gesu_") or
fn.startswith("data/medical/gea2_") or
fn.startswith("data/medical/gem_") or
fn.startswith("data/medical/gech_") or
fn.startswith("data/medical/geca_") or
fn.startswith("data/medical/gecd_") or
fn.startswith("data/medical/gegd_") or
fn.startswith("data/medical/gend_") or
fn.startswith("data/medical/gec_") or
fn.startswith("data/medical/genh_") or
fn.startswith("data/medical/nwaz_")):
return ""
file = open(fn, 'rb')
data = file.read()
file.close()
# remove gale: namespace from attributes
data = re.sub("gale:", "", data)
dom = parseString(data)
text = ""
paragraphs = dom.getElementsByTagName("p")
for paragraph in paragraphs:
xml = paragraph.toxml()
xml = re.sub("\n", " ", xml)
xml = re.sub("<.*?>", "", xml)
text = text + " " + xml
text = re.sub("\\s+", " ", text)
text = text.strip()
text = text.encode("ascii", "ignore")
return text
def legal_plaintext(fn):
print "processing", fn
file = open(fn, 'rb')
data = file.read()
data = re.sub("é", "e", data)
data = re.sub("á", "a", data)
data = re.sub("ý", "y", data)
data = re.sub(" ", " ", data)
data = re.sub("&tm;", "(TM)", data)
data = re.sub("®", "(R)", data)
data = re.sub("à", "a", data)
data = re.sub("è", "e", data)
data = re.sub("ì", "i", data)
data = re.sub("ê", "e", data)
data = re.sub("ô", "o", data)
data = re.sub("î", "i", data)
data = re.sub("ç", "c", data)
data = re.sub("&", "and", data)
data = re.sub("ä", "a", data)
data = re.sub("ß", "ss", data)
data = re.sub("æ", "e", data)
data = re.sub("ï", "i", data)
data = re.sub("ë", "e", data)
data = re.sub("ö", "o", data)
data = re.sub("ü", "u", data)
data = re.sub("â", "a", data)
data = re.sub("ø", "o", data)
data = re.sub("ñ", "n", data)
data = re.sub("É", "E", data)
data = re.sub("Å", "A", data)
data = re.sub("Ö", "O", data)
data = unicodedata.normalize("NFKD",
unicode(data, 'iso-8859-1')).encode("ascii", "ignore")
# fix "id=xxx" pattern, causes XML parsing to fail
data = re.sub("\"id=", "id=\"", data)
file.close()
text = ""
dom = parseString(data)
sentencesEl = dom.getElementsByTagName("sentences")[0]
for sentenceEl in sentencesEl.childNodes:
if sentenceEl.nodeType == Node.ELEMENT_NODE:
stext = sentenceEl.firstChild.data
if len(stext.strip()) == 0:
continue
text = text + " " + re.sub("\n", " ", stext)
text = re.sub("\\s+", " ", text)
text = text.strip()
text = text.encode("ascii", "ignore")
return text
def parse_to_plaintext(dirs, labels, funcs, sent_file, label_file):
fsent = open(sent_file, 'wb')
flabs = open(label_file, 'wb')
idx = 0
for dir in dirs:
files = glob.glob("/".join([dir, "*.xml"]))
for file in files:
text = funcs[idx](file)
if len(text.strip()) > 0:
for sentence in nltk.sent_tokenize(text):
fsent.write("%s\n" % sentence)
flabs.write("%d\n" % labels[idx])
idx += 1
fsent.close()
flabs.close()
def main():
parse_to_plaintext(["data/medical", "data/legal"],
[1, 0], [medical_plaintext, legal_plaintext],
"data/sentences.txt", "data/labels.txt")
if __name__ == "__main__":
main()
================================================
FILE: src/phrases/interesting_phrases.py
================================================
from __future__ import division
import operator
import nltk
import numpy as np
from scipy.stats import binom
import string
def isValid(word):
if word.startswith("#"):
return False # no hashtag
else:
vword = word.translate(string.maketrans("", ""), string.punctuation)
return len(vword) == len(word)
def llr(c1, c2, c12, n):
# H0: Independence p(w1,w2) = p(w1,~w2) = c2/N
p0 = c2 / n
# H1: Dependence, p(w1,w2) = c12/N
p10 = c12 / n
# H1: p(~w1,w2) = (c2-c12)/N
p11 = (c2 - c12) / n
# binomial probabilities
# H0: b(c12; c1, p0), b(c2-c12; N-c1, p0)
# H1: b(c12, c1, p10), b(c2-c12; N-c1, p11)
probs = np.matrix([
[binom(c1, p0).logpmf(c12), binom(n - c1, p0).logpmf(c2 - c12)],
[binom(c1, p10).logpmf(c12), binom(n - c1, p11).logpmf(c2 - c12)]])
# LLR = p(H1) / p(H0)
return np.sum(probs[1, :]) - np.sum(probs[0, :])
def isLikelyNGram(ngram, phrases):
if len(ngram) == 2:
return True
prevGram = ngram[:-1]
return phrases.has_key(prevGram)
def main():
# accumulate words and word frequency distributions
lines = []
unigramFD = nltk.FreqDist()
fin = open("twitter_messages.txt", 'rb')
i = 0
for line in fin:
i += 1
words = nltk.word_tokenize(line.strip().lower())
words = filter(lambda x: isValid(x), words)
[unigramFD.inc(x) for x in words]
lines.append(words)
if i > 1000:
break
fin.close()
# identify likely phrases using a multi-pass algorithm based
# on the LLR approach described in the Building Search Applications
# Lucene, LingPipe and GATE book, except that we treat n-gram
# collocations beyond 2 as n-1 gram plus a unigram.
phrases = nltk.defaultdict(float)
prevGramFD = None
for i in range(2, 5):
ngramFD = nltk.FreqDist()
for words in lines:
nextGrams = nltk.ngrams(words, i)
nextGrams = filter(lambda x: isLikelyNGram(x, phrases), nextGrams)
[ngramFD.inc(x) for x in nextGrams]
for k, v in ngramFD.iteritems():
if v > 1:
c1 = unigramFD[k[0]] if prevGramFD == None else prevGramFD[k[:-1]]
c2 = unigramFD[k[1]] if prevGramFD == None else unigramFD[k[len(k) - 1]]
c12 = ngramFD[k]
n = unigramFD.N() if prevGramFD == None else prevGramFD.N()
phrases[k] = llr(c1, c2, c12, n)
# only consider bigrams where LLR > 0, ie P(H1) > P(H0)
likelyPhrases = nltk.defaultdict(float)
likelyPhrases.update([(k, v) for (k, v)
in phrases.iteritems() if len(k) == i and v > 0])
print "==== #-grams = %d ====" % (i)
sortedPhrases = sorted(likelyPhrases.items(),
key=operator.itemgetter(1), reverse=True)
for k, v in sortedPhrases:
print k, v
prevGramFD = ngramFD
if __name__ == "__main__":
main()
================================================
FILE: src/phrases/preprocess.py
================================================
from __future__ import division
import json
import sys
def main():
if len(sys.argv) != 2:
print "Usage: %s /path/to/twitter/json/list.txt"
sys.exit(-1)
fin = open(sys.argv[1], 'rb')
fout = open("twitter_messages.txt", 'wb')
for line in fin:
try:
data = json.loads(line.strip())
lang = data["lang"]
if lang == "en":
tweet = data["text"]
tweet = tweet.replace("\n", " ").replace("\\s+", " ")
tweet = tweet.encode("ascii", "ignore")
if len(tweet) == 0:
continue
fout.write("%s\n" % (tweet))
except KeyError:
continue
fin.close()
fout.close()
if __name__ == "__main__":
main()
================================================
FILE: src/sameword/same_word_finder.py
================================================
from __future__ import division
from nltk.corpus import wordnet as wn
import sys
def similarity(w1, w2, sim=wn.path_similarity):
synsets1 = wn.synsets(w1)
synsets2 = wn.synsets(w2)
sim_scores = []
for synset1 in synsets1:
for synset2 in synsets2:
sim_scores.append(sim(synset1, synset2))
if len(sim_scores) == 0:
return 0
else:
return max(sim_scores)
def main():
f = open(sys.argv[1], 'rb')
for line in f:
(word1, word2) = line.strip().split("\t")
if similarity(word1, word2) != 1.0:
print word1
f.close()
if __name__ == "__main__":
main()
================================================
FILE: src/semantic/short_sentence_similarity.py
================================================
# Python/NLTK implementation of algorithm to detect similarity between
# short sentences described in the paper - "Sentence Similarity based
# on Semantic Nets and Corpus Statistics" by Li, et al.
# Results achieved are NOT identical to that reported in the paper, but
# this is very likely due to the differences in the way the algorithm was
# described in the paper and how I implemented it.
from __future__ import division
import nltk
from nltk.corpus import wordnet as wn
from nltk.corpus import brown
import math
import numpy as np
import sys
# Parameters to the algorithm. Currently set to values that was reported
# in the paper to produce "best" results.
ALPHA = 0.2
BETA = 0.45
ETA = 0.4
PHI = 0.2
DELTA = 0.85
brown_freqs = dict()
N = 0
######################### word similarity ##########################
def get_best_synset_pair(word_1, word_2):
"""
Choose the pair with highest path similarity among all pairs.
Mimics pattern-seeking behavior of humans.
"""
max_sim = -1.0
synsets_1 = wn.synsets(word_1)
synsets_2 = wn.synsets(word_2)
if len(synsets_1) == 0 or len(synsets_2) == 0:
return None, None
else:
max_sim = -1.0
best_pair = None, None
for synset_1 in synsets_1:
for synset_2 in synsets_2:
sim = wn.path_similarity(synset_1, synset_2)
if sim > max_sim:
max_sim = sim
best_pair = synset_1, synset_2
return best_pair
def length_dist(synset_1, synset_2):
"""
Return a measure of the length of the shortest path in the semantic
ontology (Wordnet in our case as well as the paper's) between two
synsets.
"""
l_dist = sys.maxint
if synset_1 is None or synset_2 is None:
return 0.0
if synset_1 == synset_2:
# if synset_1 and synset_2 are the same synset return 0
l_dist = 0.0
else:
wset_1 = set([str(x.name()) for x in synset_1.lemmas()])
wset_2 = set([str(x.name()) for x in synset_2.lemmas()])
if len(wset_1.intersection(wset_2)) > 0:
# if synset_1 != synset_2 but there is word overlap, return 1.0
l_dist = 1.0
else:
# just compute the shortest path between the two
l_dist = synset_1.shortest_path_distance(synset_2)
if l_dist is None:
l_dist = 0.0
# normalize path length to the range [0,1]
return math.exp(-ALPHA * l_dist)
def hierarchy_dist(synset_1, synset_2):
"""
Return a measure of depth in the ontology to model the fact that
nodes closer to the root are broader and have less semantic similarity
than nodes further away from the root.
"""
h_dist = sys.maxint
if synset_1 is None or synset_2 is None:
return h_dist
if synset_1 == synset_2:
# return the depth of one of synset_1 or synset_2
h_dist = max([x[1] for x in synset_1.hypernym_distances()])
else:
# find the max depth of least common subsumer
hypernyms_1 = {x[0]:x[1] for x in synset_1.hypernym_distances()}
hypernyms_2 = {x[0]:x[1] for x in synset_2.hypernym_distances()}
lcs_candidates = set(hypernyms_1.keys()).intersection(
set(hypernyms_2.keys()))
if len(lcs_candidates) > 0:
lcs_dists = []
for lcs_candidate in lcs_candidates:
lcs_d1 = 0
if hypernyms_1.has_key(lcs_candidate):
lcs_d1 = hypernyms_1[lcs_candidate]
lcs_d2 = 0
if hypernyms_2.has_key(lcs_candidate):
lcs_d2 = hypernyms_2[lcs_candidate]
lcs_dists.append(max([lcs_d1, lcs_d2]))
h_dist = max(lcs_dists)
else:
h_dist = 0
return ((math.exp(BETA * h_dist) - math.exp(-BETA * h_dist)) /
(math.exp(BETA * h_dist) + math.exp(-BETA * h_dist)))
def word_similarity(word_1, word_2):
synset_pair = get_best_synset_pair(word_1, word_2)
return (length_dist(synset_pair[0], synset_pair[1]) *
hierarchy_dist(synset_pair[0], synset_pair[1]))
######################### sentence similarity ##########################
def most_similar_word(word, word_set):
"""
Find the word in the joint word set that is most similar to the word
passed in. We use the algorithm above to compute word similarity between
the word and each word in the joint word set, and return the most similar
word and the actual similarity value.
"""
max_sim = -1.0
sim_word = ""
for ref_word in word_set:
sim = word_similarity(word, ref_word)
if sim > max_sim:
max_sim = sim
sim_word = ref_word
return sim_word, max_sim
def info_content(lookup_word):
"""
Uses the Brown corpus available in NLTK to calculate a Laplace
smoothed frequency distribution of words, then uses this information
to compute the information content of the lookup_word.
"""
global N
if N == 0:
# poor man's lazy evaluation
for sent in brown.sents():
for word in sent:
word = word.lower()
if not brown_freqs.has_key(word):
brown_freqs[word] = 0
brown_freqs[word] = brown_freqs[word] + 1
N = N + 1
lookup_word = lookup_word.lower()
n = 0 if not brown_freqs.has_key(lookup_word) else brown_freqs[lookup_word]
return 1.0 - (math.log(n + 1) / math.log(N + 1))
def semantic_vector(words, joint_words, info_content_norm):
"""
Computes the semantic vector of a sentence. The sentence is passed in as
a collection of words. The size of the semantic vector is the same as the
size of the joint word set. The elements are 1 if a word in the sentence
already exists in the joint word set, or the similarity of the word to the
most similar word in the joint word set if it doesn't. Both values are
further normalized by the word's (and similar word's) information content
if info_content_norm is True.
"""
sent_set = set(words)
semvec = np.zeros(len(joint_words))
i = 0
for joint_word in joint_words:
if joint_word in sent_set:
# if word in union exists in the sentence, s(i) = 1 (unnormalized)
semvec[i] = 1.0
if info_content_norm:
semvec[i] = semvec[i] * math.pow(info_content(joint_word), 2)
else:
# find the most similar word in the joint set and set the sim value
sim_word, max_sim = most_similar_word(joint_word, sent_set)
semvec[i] = PHI if max_sim > PHI else 0.0
if info_content_norm:
semvec[i] = semvec[i] * info_content(joint_word) * info_content(sim_word)
i = i + 1
return semvec
def semantic_similarity(sentence_1, sentence_2, info_content_norm):
"""
Computes the semantic similarity between two sentences as the cosine
similarity between the semantic vectors computed for each sentence.
"""
words_1 = nltk.word_tokenize(sentence_1)
words_2 = nltk.word_tokenize(sentence_2)
joint_words = set(words_1).union(set(words_2))
vec_1 = semantic_vector(words_1, joint_words, info_content_norm)
vec_2 = semantic_vector(words_2, joint_words, info_content_norm)
return np.dot(vec_1, vec_2.T) / (np.linalg.norm(vec_1) * np.linalg.norm(vec_2))
######################### word order similarity ##########################
def word_order_vector(words, joint_words, windex):
"""
Computes the word order vector for a sentence. The sentence is passed
in as a collection of words. The size of the word order vector is the
same as the size of the joint word set. The elements of the word order
vector are the position mapping (from the windex dictionary) of the
word in the joint set if the word exists in the sentence. If the word
does not exist in the sentence, then the value of the element is the
position of the most similar word in the sentence as long as the similarity
is above the threshold ETA.
"""
wovec = np.zeros(len(joint_words))
i = 0
wordset = set(words)
for joint_word in joint_words:
if joint_word in wordset:
# word in joint_words found in sentence, just populate the index
wovec[i] = windex[joint_word]
else:
# word not in joint_words, find most similar word and populate
# word_vector with the thresholded similarity
sim_word, max_sim = most_similar_word(joint_word, wordset)
if max_sim > ETA:
wovec[i] = windex[sim_word]
else:
wovec[i] = 0
i = i + 1
return wovec
def word_order_similarity(sentence_1, sentence_2):
"""
Computes the word-order similarity between two sentences as the normalized
difference of word order between the two sentences.
"""
words_1 = nltk.word_tokenize(sentence_1)
words_2 = nltk.word_tokenize(sentence_2)
joint_words = list(set(words_1).union(set(words_2)))
windex = {x[1]: x[0] for x in enumerate(joint_words)}
r1 = word_order_vector(words_1, joint_words, windex)
r2 = word_order_vector(words_2, joint_words, windex)
return 1.0 - (np.linalg.norm(r1 - r2) / np.linalg.norm(r1 + r2))
######################### overall similarity ##########################
def similarity(sentence_1, sentence_2, info_content_norm):
"""
Calculate the semantic similarity between two sentences. The last
parameter is True or False depending on whether information content
normalization is desired or not.
"""
return DELTA * semantic_similarity(sentence_1, sentence_2, info_content_norm) + \
(1.0 - DELTA) * word_order_similarity(sentence_1, sentence_2)
######################### main / test ##########################
# the results of the algorithm are largely dependent on the results of
# the word similarities, so we should test this first...
word_pairs = [
["asylum", "fruit", 0.21],
["autograph", "shore", 0.29],
["autograph", "signature", 0.55],
["automobile", "car", 0.64],
["bird", "woodland", 0.33],
["boy", "rooster", 0.53],
["boy", "lad", 0.66],
["boy", "sage", 0.51],
["cemetery", "graveyard", 0.73],
["coast", "forest", 0.36],
["coast", "shore", 0.76],
["cock", "rooster", 1.00],
["cord", "smile", 0.33],
["cord", "string", 0.68],
["cushion", "pillow", 0.66],
["forest", "graveyard", 0.55],
["forest", "woodland", 0.70],
["furnace", "stove", 0.72],
["glass", "tumbler", 0.65],
["grin", "smile", 0.49],
["gem", "jewel", 0.83],
["hill", "woodland", 0.59],
["hill", "mound", 0.74],
["implement", "tool", 0.75],
["journey", "voyage", 0.52],
["magician", "oracle", 0.44],
["magician", "wizard", 0.65],
["midday", "noon", 1.0],
["oracle", "sage", 0.43],
["serf", "slave", 0.39]
]
for word_pair in word_pairs:
print "%s\t%s\t%.2f\t%.2f" % (word_pair[0], word_pair[1], word_pair[2],
word_similarity(word_pair[0], word_pair[1]))
sentence_pairs = [
["I like that bachelor.", "I like that unmarried man.", 0.561],
["John is very nice.", "Is John very nice?", 0.977],
["Red alcoholic drink.", "A bottle of wine.", 0.585],
["Red alcoholic drink.", "Fresh orange juice.", 0.611],
["Red alcoholic drink.", "An English dictionary.", 0.0],
["Red alcoholic drink.", "Fresh apple juice.", 0.420],
["A glass of cider.", "A full cup of apple juice.", 0.678],
["It is a dog.", "That must be your dog.", 0.739],
["It is a dog.", "It is a log.", 0.623],
["It is a dog.", "It is a pig.", 0.790],
["Dogs are animals.", "They are common pets.", 0.738],
["Canis familiaris are animals.", "Dogs are common pets.", 0.362],
["I have a pen.", "Where do you live?", 0.0],
["I have a pen.", "Where is ink?", 0.129],
["I have a hammer.", "Take some nails.", 0.508],
["I have a hammer.", "Take some apples.", 0.121]
]
for sent_pair in sentence_pairs:
print "%s\t%s\t%.3f\t%.3f\t%.3f" % (sent_pair[0], sent_pair[1], sent_pair[2],
similarity(sent_pair[0], sent_pair[1], False),
similarity(sent_pair[0], sent_pair[1], True))
================================================
FILE: src/similar-tweets-nmslib/01-load-sqlite3.py
================================================
import os
import sqlite3
##################################################################
# Script to read and parse multiple tweet files and load them
# into a SQLite3 DB for later retrieval.
##################################################################
DATA_DIR = "../data"
INPUT_DIR = os.path.join(DATA_DIR, "Health-Tweets")
DB_FILE = os.path.join(DATA_DIR, "tweets.db")
# create database
conn = sqlite3.connect(DB_FILE)
# create table if not exists
cur = conn.cursor()
try:
cur.execute("""
CREATE TABLE IF NOT EXISTS tweets (
t_id VARCHAR(32) NOT NULL,
t_dttm VARCHAR(50) NOT NULL,
t_text VARCHAR(255) NOT NULL
)
""")
cur.execute("""
CREATE UNIQUE INDEX IF NOT EXISTS ix_tweets ON tweets(t_id)
""")
except sqlite3.Error as e:
print("Failed to create table tweets and unique index")
raise e
finally:
if cur: cur.close()
num_written = 0
insert_sql = """
INSERT INTO tweets(t_id, t_dttm, t_text) VALUES (?, ?, ?)
"""
for filename in os.listdir(INPUT_DIR):
print("Now processing: {:s}".format(filename))
fin = open(os.path.join(INPUT_DIR, filename), "r", encoding="utf8")
for line in fin:
cols = line.strip().split('|')
if len(cols) != 3:
continue
if num_written % 1000 == 0:
print("{:d} rows added".format(num_written))
conn.commit()
t_id, t_dttm, t_text = cols
t_text = " ".join([w for w in t_text.split() if not w.startswith("http://")])
# print(t_id, t_dttm, t_text)
try:
cur = conn.cursor()
cur.execute(insert_sql, (t_id, t_dttm, t_text))
except sqlite3.Error as e:
print("Error inserting data")
raise e
finally:
if cur: cur.close()
num_written += 1
fin.close()
print("{:d} rows added, COMPLETE".format(num_written))
conn.commit()
================================================
FILE: src/similar-tweets-nmslib/02-generate-vectors.py
================================================
import json
import numpy as np
import os
import sqlite3
from bert_serving.client import BertClient
##################################################################
# Script to generate BERT vectors for all the tweet texts in
# SQLite3 database.
##################################################################
bc = BertClient()
conn = sqlite3.connect("tweets.db")
fout = open("vectors.tsv", "w")
num_processed = 0
select_sql = """SELECT t_id, t_dttm, t_text FROM tweets"""
cur = conn.cursor()
cur.execute(select_sql)
for row in cur.fetchall():
if num_processed % 1000 == 0:
print("{:d} rows processed".format(num_processed))
try:
embeddings = bc.encode([row[2]])
except ValueError:
continue
t_vec = ",".join(["{:3e}".format(e) for e in embeddings[0].tolist()])
fout.write("{:s}\t{:s}\n".format(row[0], t_vec))
num_processed += 1
print("{:d} rows processed, COMPLETE".format(num_processed))
fout.close()
cur.close()
conn.close()
================================================
FILE: src/similar-tweets-nmslib/03-query-times.py
================================================
import nmslib
import numpy as np
import os
import sqlite3
import time
DATA_DIR = "../data"
TWEET_DB = os.path.join(DATA_DIR, "tweets.db")
VECTORS_FILE = os.path.join(DATA_DIR, "vectors.tsv")
RESULTS_FILE = os.path.join(DATA_DIR, "results.tsv")
NMS_INDEX = os.path.join(DATA_DIR, "tweet-vectors.index")
MAX_NUM_VECTORS = 63111
INDEX_SAMPLES = 63111
QUERY_SAMPLES = 50
def lookup_tweet_by_id(tweet_id):
try:
conn = sqlite3.connect(TWEET_DB)
cur = conn.cursor()
cur.execute("""SELECT t_text FROM tweets WHERE t_id = '%s' """ % (tweet_id))
row = cur.fetchone()
return row[0]
except sqlite3.Error as e:
raise e
finally:
if cur: cur.close()
if conn: conn.close()
# build vector data for required number of samples
index_positions = set(
np.random.random_integers(low=0, high=MAX_NUM_VECTORS, size=INDEX_SAMPLES)
.tolist())
query_positions = set(
np.random.random_integers(low=0, high=MAX_NUM_VECTORS, size=QUERY_SAMPLES)
.tolist())
index_vecs = np.empty((INDEX_SAMPLES, 768))
query_vecs = np.empty((QUERY_SAMPLES, 768))
index_pos2id, query_pos2id = {}, {}
fvec = open(VECTORS_FILE, "r")
curr_index_position, curr_query_position = 0, 0
for lid, line in enumerate(fvec):
if lid in index_positions or lid in query_positions:
t_id, t_vec = line.strip().split('\t')
t_vec_arr = np.array([float(v) for v in t_vec.split(',')])
if lid in index_positions:
index_vecs[curr_index_position] = t_vec_arr
index_pos2id[curr_index_position] = t_id
curr_index_position += 1
else: # lid in query_positions:
query_vecs[curr_query_position] = t_vec_arr
query_pos2id[curr_query_position] = t_id
curr_query_position += 1
else:
continue
fvec.close()
# load
start_tm = time.time()
index = nmslib.init(method='hnsw', space='cosinesimil')
index.addDataPointBatch(index_vecs)
index.createIndex({'post': 2}, print_progress=True)
elapsed_tm = time.time() - start_tm
print("load elapsed time (s): {:.3f}".format(elapsed_tm))
index.saveIndex(NMS_INDEX, save_data=True)
fout = open(RESULTS_FILE, "w")
query_times = []
for i in range(query_vecs.shape[0]):
try:
start_tm = time.time()
q_tid = query_pos2id[i]
q_text = lookup_tweet_by_id(q_tid)
fout.write("query: {:s} ({:s})\n".format(q_text, q_tid))
rids, distances = index.knnQuery(query_vecs[i], k=10)
for rid, distance in zip(rids, distances):
r_tid = index_pos2id[rid]
r_text = lookup_tweet_by_id(r_tid)
fout.write("{:.3f} {:s} {:s}\n".format(distance, r_tid, r_text))
query_times.append(time.time() - start_tm)
except KeyError:
continue
fout.close()
print("average query elapsed time (s): {:.3f}".format(sum(query_times) / len(query_times)))
================================================
FILE: src/similar-tweets-nmslib/04-chart-times.py
================================================
#%%
import matplotlib.pyplot as plt
num_recs = [1000, 5000, 10000, 20000, 40000, 63111]
index_load_times = [0.163, 1.471, 4.655, 11.402, 28.614, 53.969]
# query_times = [0.018, 0.013, 0.020, 0.051, 0.033, 0.054]
query_times = [0.018, 0.020, 0.028, 0.045, 0.051, 0.054]
plt.plot(num_recs, index_load_times, marker="o", color="r")
plt.title("Index Load times")
plt.xlabel("number of records")
plt.ylabel("load time (s)")
plt.show()
# plt.plot(num_recs, query_times, marker="o", color="r")
# plt.title("Query times")
# plt.xlabel("number of records")
# plt.ylabel("query time (s)")
# plt.show()
# %%
================================================
FILE: src/similar-tweets-nmslib/README.md
================================================
Supporting code for my blog post [Finding Similar Tweets with BERT and NMSLib](https://sujitpal.blogspot.com/2019/12/finding-similar-tweets-with-bert-and.html).
================================================
FILE: src/stlclust/cluster_titles.py
================================================
import os
import numpy as np
from sklearn.cluster import DBSCAN
from scipy.io import mmread
OUTPUT_DIR = "../../data/stlclust"
X = mmread(os.path.join(OUTPUT_DIR, "stitles.mtx"))
clust = DBSCAN(eps=0.1, min_samples=5, metric="precomputed")
clust.fit(X)
# print cluster report
stitles = []
ftitles = open(os.path.join(OUTPUT_DIR, "stitles.txt"), 'rb')
for line in ftitles:
stitles.append(line.strip().split("\t")[0])
ftitles.close()
preds = clust.labels_
clabels = np.unique(preds)
for i in range(clabels.shape[0]):
if clabels[i] < 0:
continue
cmem_ids = np.where(preds == clabels[i])[0]
cmembers = []
for cmem_id in cmem_ids:
cmembers.append(stitles[cmem_id])
print "Cluster#%d: %s" % (i, ", ".join(cmembers))
================================================
FILE: src/stlclust/extract_stl.py
================================================
import os
import nltk
import string
import re
from operator import itemgetter
INPUT_DIR = "/home/sujit/Projects/med_data/mtcrawler/texts"
OUTPUT_DIR = "../../data/stlclust"
PUNCTUATIONS = set([c for c in string.punctuation])
DIGITS = set([c for c in string.digits])
BULLETS = re.compile("[0-9IVXA-Za-z]{0,3}\.")
PUNCTS = re.compile(r"[" + string.punctuation + "]")
def find_first(line, cs):
idxs = []
for c in cs:
c_index = line.find(c)
if c_index > -1:
# if this occurs after an existing punctuation, then discard
prev_chars = set([pc for pc in line[0:c_index - 1]])
if len(PUNCTUATIONS.intersection(prev_chars)) > 0:
return -1
# make sure this position is either EOL or followed by space
if c_index + 1 == len(line) or line[c_index + 1] == ' ':
idxs.append(c_index)
if len(idxs) == 0:
return -1
else:
return min(idxs)
stfd = nltk.FreqDist()
for filename in os.listdir(INPUT_DIR):
f = open(os.path.join(INPUT_DIR, filename), 'rb')
for line in f:
line = line.strip()
if len(line) == 0:
continue
# Isolate section titles from text. Titles are leading phrases
# terminated by colon or hyphen. Usually all-caps but can be in
# mixed-case also
sec_title = None
corh = find_first(line, [":", "-"])
if corh > -1:
sec_title = line[0:corh]
# Alternatively, if the line is all caps, then it is also a
# section title
if sec_title is None and line.upper() == line:
sec_title = line
if sec_title is not None:
# Remove retrieved titles with leading arabic number, roman number
# and alpha bullets (allow max 3) bullets
if re.match(BULLETS, sec_title) is not None:
continue
# Remove sections that look like dates (all numbers once puncts)
# are removed
if re.sub(PUNCTS, "", sec_title).isdigit():
continue
# if retrieved title is mixed case remove any that have > 4 words
if sec_title != sec_title.upper() and len(sec_title.split()) > 4:
continue
# if retrieved title contains special chars, remove
if "," in sec_title:
continue
# replace "diagnoses" with "diagnosis"
sec_title = re.sub("DIAGNOSES", "DIAGNOSIS", sec_title)
stfd[sec_title] += 1
f.close()
# output the frequency distribution
fout = open(os.path.join(OUTPUT_DIR, "stitles.txt"), 'wb')
for k, v in sorted(stfd.items(), key=itemgetter(1), reverse=True):
fout.write("%s\t%d\n" % (k, v))
fout.close()
================================================
FILE: src/stlclust/fuzz_similarity.py
================================================
from __future__ import division
import os
import numpy as np
from scipy.io import mmwrite
from fuzzywuzzy import fuzz
OUTPUT_DIR = "../../data/stlclust"
def compute_similarity(s1, s2):
return 1.0 - (0.01 * max(
fuzz.ratio(s1, s2),
fuzz.token_sort_ratio(s1, s2),
fuzz.token_set_ratio(s1, s2)))
cutoff = 2
stitles = []
fin = open(os.path.join(OUTPUT_DIR, "stitles.txt"), 'rb')
for line in fin:
stitle, count = line.strip().split("\t")
if int(count) < cutoff:
continue
stitles.append(stitle)
fin.close()
X = np.zeros((len(stitles), len(stitles)))
for i in range(len(stitles)):
if i > 0 and i % 10 == 0:
print "Processed %d/%d rows of data" % (i, X.shape[0])
for j in range(len(stitles)):
if X[i, j] == 0.0:
X[i, j] = compute_similarity(stitles[i].lower(), stitles[j].lower())
X[j, i] = X[i, j]
# write to Matrix Market format for passing to DBSCAN
mmwrite(os.path.join(OUTPUT_DIR, "stitles.mtx"), X)
================================================
FILE: src/topicmodel/bok_model.py
================================================
# -*- coding: utf-8 -*-
import logging
import os
import gensim
def iter_docs(topdir):
for f in os.listdir(topdir):
fin = open(os.path.join(topdir, f), 'rb')
text = fin.read()
fin.close()
yield (x for x in text.split(" "))
class MyBokCorpus(object):
def __init__(self, topdir):
self.topdir = topdir
self.dictionary = gensim.corpora.Dictionary(iter_docs(topdir))
def __iter__(self):
for tokens in iter_docs(self.topdir):
yield self.dictionary.doc2bow(tokens)
logging.basicConfig(format="%(asctime)s : %(levelname)s : %(message)s",
level=logging.INFO)
BOK_DIR = "/Users/palsujit/Projects/med_data/mtcrawler/kea_keys"
MODELS_DIR = "models"
corpus = MyBokCorpus(BOK_DIR)
tfidf = gensim.models.TfidfModel(corpus, normalize=True)
corpus_tfidf = tfidf[corpus]
corpus.dictionary.save(os.path.join(MODELS_DIR, "bok.dict"))
gensim.corpora.MmCorpus.serialize(os.path.join(MODELS_DIR, "bok.mm"),
corpus_tfidf)
================================================
FILE: src/topicmodel/bow_model.py
================================================
import logging
import os
import nltk
import gensim
def iter_docs(topdir, stoplist):
for fn in os.listdir(topdir):
fin = open(os.path.join(topdir, fn), 'rb')
text = fin.read()
fin.close()
yield (x for x in
gensim.utils.tokenize(text, lowercase=True, deacc=True, errors="ignore")
if x not in stoplist)
class MyCorpus(object):
def __init__(self, topdir, stoplist):
self.topdir = topdir
self.stoplist = stoplist
self.dictionary = gensim.corpora.Dictionary(iter_docs(topdir, stoplist))
def __iter__(self):
for tokens in iter_docs(self.topdir, self.stoplist):
yield self.dictionary.doc2bow(tokens)
logging.basicConfig(format='%(asctime)s : %(levelname)s : %(message)s', level=logging.INFO)
TEXTS_DIR = "/home/sujit/Projects/mlia-examples/data/mtcrawler/gensim"
MODELS_DIR = "models"
stoplist = set(nltk.corpus.stopwords.words("english"))
corpus = MyCorpus(TEXTS_DIR, stoplist)
corpus.dictionary.save(os.path.join(MODELS_DIR, "mtsamples.dict"))
gensim.corpora.MmCorpus.serialize(os.path.join(MODELS_DIR, "mtsamples.mm"), corpus)
================================================
FILE: src/topicmodel/gensim_preprocess.py
================================================
import json
import os
JSONS_DIR = "/home/sujit/Projects/mlia-examples/data/mtcrawler/jsons"
TEXTS_DIR = "/home/sujit/Projects/mlia-examples/data/mtcrawler/gensim"
for fn in os.listdir(JSONS_DIR):
print "Converting JSON: %s" % (fn)
fjson = open(os.path.join(JSONS_DIR, fn), 'rb')
data = json.load(fjson)
fjson.close()
tfn = os.path.splitext(fn)[0] + ".txt"
ftext = open(os.path.join(TEXTS_DIR, tfn), 'wb')
ftext.write(data["text"].encode("utf-8"))
ftext.close()
================================================
FILE: src/topicmodel/gensim_word2vec.py
================================================
import string
import nltk
import numpy as np
from cStringIO import StringIO
from gensim.models import word2vec
import logging
logging.basicConfig(format="%(asctime)s: %(levelname)s : %(message)s",
level=logging.INFO)
# load data
fin = open("/home/sujit/Projects/scalcium/src/main/resources/langmodel/raw_sentences.txt", 'rb')
puncts = set([c for c in string.punctuation])
sentences = []
for line in fin:
# each sentence is a list of words, we lowercase and remove punctuations
# same as the Scala code
sentences.append([w for w in nltk.word_tokenize(line.strip().lower())
if w not in puncts])
fin.close()
# train word2vec with sentences
model = word2vec.Word2Vec(sentences, size=100, window=4, min_count=1, workers=4)
model.init_sims(replace=True)
# find 10 words closest to "day"
print "words most similar to 'day':"
print model.most_similar(positive=["day"], topn=10)
# find closest word to "he"
print "words most similar to 'he':"
print model.most_similar(positive=["he"], topn=1)
# for each word in the vocabulary, write out the word vectors to a file
fvec = open("/tmp/word_vectors.txt", 'wb')
for word in model.vocab.keys():
vec = model[word]
for i in range(vec.shape[0]):
s = StringIO()
np.savetxt(s, vec, fmt="%.5f", newline=",")
fvec.write("%s%s\n" % (s.getvalue(), word))
fvec.close()
================================================
FILE: src/topicmodel/kea_preprocess.py
================================================
import json
import os
import random
import shutil
JSONS_DIR = "/Users/palsujit/Projects/med_data/mtcrawler/jsons"
KEA_TRAIN_DIR = "/Users/palsujit/Projects/med_data/mtcrawler/kea/train"
KEA_TEST_DIR = "/Users/palsujit/Projects/med_data/mtcrawler/kea/test"
shutil.rmtree(KEA_TRAIN_DIR)
shutil.rmtree(KEA_TEST_DIR)
os.mkdir(KEA_TRAIN_DIR)
os.mkdir(KEA_TEST_DIR)
os.mkdir(os.path.join(KEA_TEST_DIR, "keys"))
for filename in os.listdir(JSONS_DIR):
print "Converting %s..." % (filename)
fjson = open(os.path.join(JSONS_DIR, filename), 'rb')
data = json.load(fjson)
fjson.close()
basename = os.path.splitext(filename)[0]
# do a 30/70 split for training vs test
train = random.uniform(0, 1) <= 0.1
txtdir = KEA_TRAIN_DIR if train else KEA_TEST_DIR
ftxt = open(os.path.join(txtdir, basename + ".txt"), 'wb')
ftxt.write(data["text"].encode("utf-8"))
ftxt.close()
# write keywords
keydir = KEA_TRAIN_DIR if train else os.path.join(KEA_TEST_DIR, "keys")
fkey = open(os.path.join(keydir, basename + ".key"), 'wb')
keywords = data["keywords"]
for keyword in keywords:
fkey.write("%s\n" % (keyword.encode("utf-8")))
fkey.close()
================================================
FILE: src/topicmodel/keywords_merge.py
================================================
# -*- coding: utf-8 -*-
import nltk
import os
USER_KEYWORDS_DIR = "/Users/palsujit/Projects/med_data/mtcrawler/kea/test"
KEA_KEYWORDS_DIR = "/Users/palsujit/Projects/med_data/mtcrawler/kea/test/keys"
KEYWORDS_FILE = "/Users/palsujit/Projects/med_data/mtcrawler/kea/merged_keys.txt"
CUSTOM_STOPWORDS = ["patient", "normal", "mg"]
def main():
# get set of english keywords from NLTK
stopwords = set(nltk.corpus.stopwords.words("english"))
# add own corpus-based stopwords based on high IDF words
for custom_stopword in CUSTOM_STOPWORDS:
stopwords.add(custom_stopword)
keywords = set()
for f in os.listdir(USER_KEYWORDS_DIR):
# only select the .key files
if f.endswith(".txt") or f == "keys":
continue
fusr = open(os.path.join(USER_KEYWORDS_DIR, f), 'rb')
for line in fusr:
line = line.strip().lower()
if line in keywords:
continue
keywords.add(line)
fusr.close()
for f in os.listdir(KEA_KEYWORDS_DIR):
fkea = open(os.path.join(KEA_KEYWORDS_DIR, f), 'rb')
for line in fkea:
keywords.add(line.strip())
fkea.close()
fmrg = open(KEYWORDS_FILE, 'wb')
for keyword in keywords:
if keyword in stopwords:
continue
fmrg.write("%s\n" % (keyword))
fmrg.close()
if __name__ == "__main__":
main()
================================================
FILE: src/topicmodel/lda_model.py
================================================
import logging
import os
import gensim
MODELS_DIR = "models"
NUM_TOPICS = 4
logging.basicConfig(format='%(asctime)s : %(levelname)s : %(message)s', level=logging.INFO)
dictionary = gensim.corpora.Dictionary.load(os.path.join(MODELS_DIR, "bok.dict"))
corpus = gensim.corpora.MmCorpus(os.path.join(MODELS_DIR, "bok.mm"))
# Project to LDA space
lda = gensim.models.LdaModel(corpus, id2word=dictionary,
iterations=300,
num_topics=NUM_TOPICS)
ftt = open(os.path.join(MODELS_DIR, "topic_terms.csv"), 'wb')
for topic_id in range(NUM_TOPICS):
term_probs = lda.show_topic(topic_id, topn=50)
for prob, term in term_probs:
ftt.write("%d\t%s\t%.3f\n" % (topic_id, term.replace("_", " "), prob))
ftt.close()
fdt = open(os.path.join(MODELS_DIR, "doc_topics.csv"), 'wb')
for doc_id in range(len(corpus)):
docbok = corpus[doc_id]
doc_topics = lda.get_document_topics(docbok)
for topic_id, topic_prob in doc_topics:
fdt.write("%d\t%d\t%.3f\n" % (doc_id, topic_id, topic_prob))
fdt.close()
================================================
FILE: src/topicmodel/lsi_model.py
================================================
import logging
import os
import gensim
logging.basicConfig(format='%(asctime)s : %(levelname)s : %(message)s', level=logging.INFO)
MODELS_DIR = "models"
dictionary = gensim.corpora.Dictionary.load(os.path.join(MODELS_DIR, "bok.dict"))
corpus = gensim.corpora.MmCorpus(os.path.join(MODELS_DIR, "bok.mm"))
tfidf = gensim.models.TfidfModel(corpus, normalize=True)
corpus_tfidf = tfidf[corpus]
# project to 2 dimensions for visualization
lsi = gensim.models.LsiModel(corpus_tfidf, id2word=dictionary, num_topics=2)
# write out coordinates to file
fcoords = open(os.path.join(MODELS_DIR, "coords.csv"), 'wb')
for vector in lsi[corpus]:
if len(vector) != 2:
continue
fcoords.write("%6.4f\t%6.4f\n" % (vector[0][1], vector[1][1]))
fcoords.close()
================================================
FILE: src/topicmodel/num_topics.py
================================================
import os
import numpy as np
import matplotlib.pyplot as plt
from sklearn.cluster import KMeans
MODELS_DIR = "models"
MAX_K = 10
X = np.loadtxt(os.path.join(MODELS_DIR, "coords.csv"), delimiter="\t")
ks = range(1, MAX_K + 1)
inertias = np.zeros(MAX_K)
diff = np.zeros(MAX_K)
diff2 = np.zeros(MAX_K)
diff3 = np.zeros(MAX_K)
for k in ks:
kmeans = KMeans(k).fit(X)
inertias[k - 1] = kmeans.inertia_
# first difference
if k > 1:
diff[k - 1] = inertias[k - 1] - inertias[k - 2]
# second difference
if k > 2:
diff2[k - 1] = diff[k - 1] - diff[k - 2]
# third difference
if k > 3:
diff3[k - 1] = diff2[k - 1] - diff2[k - 2]
elbow = np.argmin(diff3[3:]) + 3
plt.plot(ks, inertias, "b*-")
plt.plot(ks[elbow], inertias[elbow], marker='o', markersize=12,
markeredgewidth=2, markeredgecolor='r', markerfacecolor=None)
plt.ylabel("Inertia")
plt.xlabel("K")
plt.show()
================================================
FILE: src/topicmodel/viz_doctopic_distrib.py
================================================
# -*- coding: utf-8 -*-
import random
import matplotlib.pyplot as plt
import pandas as pd
MODELS_DIR = "models"
NUM_TOPICS = 4
dtdf = pd.read_csv(os.path.join(MODELS_DIR, "doc_topics.csv"), sep="\t",
names=["doc_id", "topic_id", "topic_prob"],
skiprows=0)
# Choose 5 documents randomly for analysis
max_doc_id = dtdf["doc_id"].max()
doc_ids = []
for i in range(6):
doc_ids.append(int(random.random() * max_doc_id))
for doc_id in doc_ids:
filt = dtdf[dtdf["doc_id"] == doc_id]
topic_ids = filt["topic_id"].tolist()
topic_probs = filt["topic_prob"].tolist()
prob_dict = dict(zip(topic_ids, topic_probs))
ys = []
for i in range(NUM_TOPICS):
if prob_dict.has_key(i):
ys.append(prob_dict[i])
else:
ys.append(0.0)
plt.title("Document #%d" % (doc_id))
plt.ylabel("P(topic)")
plt.ylim(0.0, 1.0)
plt.xticks(range(NUM_TOPICS),
["Topic#%d" % (x) for x in range(NUM_TOPICS)])
plt.grid(True)
plt.bar(range(NUM_TOPICS), ys, align="center")
plt.show()
================================================
FILE: src/topicmodel/viz_topics_scatter.py
================================================
import os
import numpy as np
import matplotlib.pyplot as plt
from sklearn.cluster import KMeans
MODELS_DIR = "models"
NUM_TOPICS = 4
X = np.loadtxt(os.path.join(MODELS_DIR, "coords.csv"), delimiter="\t")
kmeans = KMeans(NUM_TOPICS).fit(X)
y = kmeans.labels_
colors = ["b", "g", "r", "m"]
for i in range(X.shape[0]):
plt.scatter(X[i][0], X[i][1], c=colors[y[i]], s=10)
plt.show()
================================================
FILE: src/topicmodel/viz_topics_wordcloud.py
================================================
import matplotlib.pyplot as plt
import os
import pandas as pd
import wordcloud
MODELS_DIR = "models"
ttdf = pd.read_csv(os.path.join(MODELS_DIR, "topic_terms.csv"),
sep="\t", skiprows=0, names=["topic_id", "term", "prob"])
topics = ttdf.groupby("topic_id").groups
for topic in topics.keys():
row_ids = topics[topic]
freqs = []
for row_id in row_ids:
row = ttdf.ix[row_id]
freqs.append((row["term"], row["prob"]))
wc = wordcloud.WordCloud()
elements = wc.fit_words(freqs)
plt.figure(figsize=(5, 5))
plt.imshow(wc)
plt.axis("off")
plt.show()
================================================
FILE: src/topicmodel/word2vec_cluster_plot.py
================================================
import matplotlib.pyplot as plt
fig = plt.figure()
ax = fig.add_subplot(111)
fin = open("../../data/word_som_online.txt", 'rb')
for line in fin:
word, x, y = line.strip().split("\t")
ax.text(int(x), int(y), word)
fin.close()
ax.axis([0, 50, 0, 50])
plt.subplots_adjust(left=0.1, right=0.9, top=0.9, bottom=0.1)
plt.title("Word Clusters (Online Training)")
plt.grid()
plt.show()
| \n", " | src | \n", "dst | \n", "sid | \n", "sent_text | \n", "
|---|---|---|---|---|
| 0 | \n", "Jared Kushner | \n", "Deutsche Bank | \n", "17 | \n", "( Eastern District of New York ) has requested records from Deutsche Bank relative to Jared Kush... | \n", "
| 1 | \n", "Jared Kushner | \n", "Deutsche Bank | \n", "249 | \n", "Trump ’s wealth manager at Deutsche , Rosemary Vrablic , specializes in real estate and is close... | \n", "
| 2 | \n", "Jared Kushner | \n", "Deutsche Bank | \n", "402 | \n", "In the final installment , we ’ll detail how Trump ’s son - in - law and White House adviser Jar... | \n", "
| 3 | \n", "Jared Kushner | \n", "Deutsche Bank | \n", "405 | \n", "This “ cooperation agreement ” becomes more pertinent when we consider Jared Kushner ’s relation... | \n", "
| 4 | \n", "Jared Kushner | \n", "Deutsche Bank | \n", "406 | \n", "When he first filed the financial disclosure forms mandated for all federal employees , Kushner ... | \n", "
| 5 | \n", "Jared Kushner | \n", "Deutsche Bank | \n", "407 | \n", "But at that time , Kushner failed to disclose the $ 285 million refinancing his firm received fr... | \n", "
| 6 | \n", "Jared Kushner | \n", "Deutsche Bank | \n", "417 | \n", "The timing of the Deutsche refinancing transaction with Kushner and the subsequent media attenti... | \n", "
| 7 | \n", "Jared Kushner | \n", "Deutsche Bank | \n", "463 | \n", "October 2016 Jared Kushner ’s business receives a $ 285 million loan from Deutsche Bank relative... | \n", "
| 8 | \n", "Jared Kushner | \n", "Deutsche Bank | \n", "464 | \n", "October 2016 Trump ’s campaign team announces that Kushner will recuse himself from any involvem... | \n", "
| 9 | \n", "Jared Kushner | \n", "Deutsche Bank | \n", "512 | \n", "Kushner must have forgotten about the promise he made to recuse himself from contact with any pa... | \n", "